Namkoong H, Edahiro R, et al.. Share DOCK2 is involved in the host genetics and biology of severe COVID-19. Nature. 2022.08; 609 (7928): 754-760. ( PubMed, DOI )

Wang QS, Edahiro R, et al.. The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force. Nat Commun. 2022.08; 13 (1): 4830. ( PubMed, DOI )

Inagaki Natsuko, Hayashi Takeharu, Takei Yasuyoshi, Kosuge Hisanori, Suzuki Shinji, Tanimoto Kousuke, Chikamori Taishiro, Kimura Akinori. 肥大型心筋症多発家系におけるRBM20遺伝子の病的バリアント(Pathogenic variant of RBM20 in a multiplex family with hypertrophic cardiomyopathy) Human Genome Variation. 2022.03; 9 1-4. ( ichushi )

Inagaki N, Hayashi T, Takei Y, Kosuge H, Suzuki S, Tanimoto K, Chikamori T, Kimura A. Pathogenic variant of RBM20 in a multiplex family with hypertrophic cardiomyopathy. Human genome variation. 2022.02; 9 (1): 6. ( PubMed, DOI )

COVID-19 Host Genetics Initiative. Mapping the human genetic architecture of COVID-19. Nature. 2021.12; 600 (7889): 472-477. ( PubMed, DOI )

Kawano Hiroaki, Kawamura Koichi, Kanda Munetake, Ishijima Mitsuaki, Abe Kuniko, Hayashi Tomayoshi, Matsumoto Yuji, Kimura Akinori, Maemura Koji. 拘束型心筋症における心筋細胞の病理組織学的変化(Histopathological changes of myocytes in restrictive cardiomyopathy) Medical Molecular Morphology. 2021.09; 54 (3): 289-295. ( ichushi )

Ueno Michihiko, Takeda Atsuhito, Yamazawa Hirokuni, Takei Kohta, Furukawa Takuo, Suzuki Yasuto, Chida-Nagai Ayako, Kimura Akinori. 症例報告　心筋トロポニンI遺伝子の稀な変異を伴う拘束型心筋症の双子の姉妹(A case report: Twin sisters with restrictive cardiomyopathy associated with rare mutations in the cardiac troponin I gene) Journal of Cardiology Cases. 2021.04; 23 (4): 154-157. ( ichushi )

Moriki Toshihiro, Kubo Toru, Sugiura Kenta, Ochi Yuri, Baba Yuichi, Hirota Takayoshi, Yamasaki Naohito, Kimura Akinori, Doi Yoshinori L., Kitaoka Hiroaki. Mayo Clinicによる表現型に基づいた遺伝子検査予測スコアの日本人肥大型心筋症患者におけるバリデーションスタディ(A Validation Study of the Mayo Clinic Phenotype-Based Genetic Test Prediction Score for Japanese Patients With Hypertrophic Cardiomyopathy) Circulation Journal. 2021.04; 85 (5): 669-674. ( ichushi )

Ueno M, Takeda A, Yamazawa H, Takei K, Furukawa T, Suzuki Y, Chida-Nagai A, Kimura A. A case report: Twin sisters with restrictive cardiomyopathy associated with rare mutations in the cardiac troponin I gene. Journal of cardiology cases. 2021.04; 23 (4): 154-157. ( PubMed, DOI )

Hirayama-Yamada Kayoko, Inagaki Natsuko, Hayashi Takeharu, Kimura Akinori. 日本人家族における家族性拡張型心筋症関連の新規タイチン切断多型およびゲノム編集済み細胞株を用いた機能解析(A Novel Titin Truncation Variant Linked to Familial Dilated Cardiomyopathy Found in a Japanese Family and Its Functional Analysis in Genome-Edited Model Cells) International Heart Journal. 2021.03; 62 (2): 359-366. ( ichushi )

Nakashima Yasuteru, Kubo Toru, Sugiura Kenta, Ochi Yuri, Takahashi Asa, Baba Yuichi, Hirota Takayoshi, Yamasaki Naohito, Kimura Akinori, Doi Yoshinori L., Kitaoka Hiroaki. 日本人肥大型心筋症患者におけるサルコメア遺伝子変異の存在が及ぼす生涯にわたる臨床的影響(Lifelong Clinical Impact of the Presence of Sarcomere Gene Mutation in Japanese Patients With Hypertrophic Cardiomyopathy) Circulation Journal. 2020.09; 84 (10): 1846-1853. ( ichushi )

Nakashima Y, Kubo T, Sugiura K, Ochi Y, Takahashi A, Baba Y, Hirota T, Yamasaki N, Kimura A, Doi YL, Kitaoka H. Lifelong Clinical Impact of the Presence of Sarcomere Gene Mutation in Japanese Patients With Hypertrophic Cardiomyopathy. Circulation journal : official journal of the Japanese Circulation Society. 2020.08; 84 (10): 1846-+. ( PubMed, DOI )

Enomoto H, Mittal N, Inomata T, Arimura T, Izumi T, Kimura A, Fukuda K, Makino S. Dilated Cardiomyopathy (DCM)-linked Heat shock protein Family D Member 1 (HSPD1) mutations cause upregulation of ROS and autophagy through mitochondrial dysfunction. Cardiovascular research. 2020.06; 117 (4): 1118-1131. ( PubMed, DOI )

Ishii Hiroshi, Matsuoka Saori, Ikeda Noriko, Kurihara Kyoko, Ueno Takamasa, Takiguchi Masafumi, Naruse Taeko K., Kimura Akinori, Yokoyama Masaru, Sato Hironori, Matano Tetsuro. Determination of a T cell receptor of potent CD8(+) T cells against simian immunodeficiency virus infection in Burmese rhesus macaques BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2020.01; 521 (4): 894-899. ( PubMed, DOI )

Higashikuse Yuta, Mittal Nishant, Arimura Takuro, Yoon Sung Han, Oda Mayumi, Enomoto Hirokazu, Kaneda Ruri, Hattori Fumiyuki, Suzuki Takeshi, Kawakami Atsushi, Gasch Alexander, Furukawa Tetsushi, Labeit Siegfried, Fukuda Keiichi, Kimura Akinori, Makino Shinji. Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients DISEASE MODELS & MECHANISMS. 2019.11; 12 (11): ( PubMed, DOI )

谷本 幸介, 成瀬 妙子, 木村 彰方. ヒト以外の動物種を対象としたNGSによるMHCタイピング法 MHC: Major Histocompatibility Complex. 2019.08; 26 (2): 115-123. ( DOI )

An J, Naruse TK, Hinohara K, Soejima Y, Sawabe M, Nakagawa Y, Kuwahara K, Kimura A. MRTF-A regulates proliferation and survival properties of pro-atherogenic macrophages. Journal of molecular and cellular cardiology. 2019.08; 133 26-35. ( PubMed, DOI )

Naruse Taeko K., Akari Hirofumi, Matano Tetsuro, Kimura Akinori. Diversity of ULBP5 in Old-World monkeys(Cercopithecidae) and divergence of the ULBP gene family in primates Proceedings of the Japan Academy Series B, Physical and Biological Sciences. 2018.12; 94 (10): 441-453. ( ichushi )

Inagaki Natsuko, Hayashi Takeharu, Takei Yasuyoshi, Tanimoto Kousuke, Chikamori Taishiro, Kimura Akinori. Clinical and genetic backgrounds of hypertrophic cardiomyopathy with mid-ventricular obstruction Journal of Human Genetics. 2018.12; 63 (12): 1273-1276. ( ichushi )

Terao C, Yoshifuji H, Matsumura T, Naruse TK, Ishii T, Nakaoka Y, Kirino Y, Matsuo K, Origuchi T, Shimizu M, Maejima Y, Amiya E, Tamura N, Kawaguchi T, Takahashi M, Setoh K, Ohmura K, Watanabe R, Horita T, Atsumi T, Matsukura M, Miyata T, Kochi Y, Suda T, Tanemoto K, Meguro A, Okada Y, Ogimoto A, Yamamoto M, Takahashi H, Nakayamada S, Saito K, Kuwana M, Mizuki N, Tabara Y, Ueda A, Komuro I, Kimura A, Isobe M, Mimori T, Matsuda F. Genetic determinants and an epistasis of <i>LILRA3</i> and HLA-B*52 in Takayasu arteritis. Proceedings of the National Academy of Sciences of the United States of America. 2018.11; ( PubMed, DOI )

Takahashi N, Matsuoka S, Thi Minh TT, Ba HP, Naruse TK, Kimura A, Shiino T, Kawana-Tachikawa A, Ishikawa K, Matano T, Nguyen Thi LA. Human leukocyte antigen-associated gag and nef polymorphisms in HIV-1 subtype A/E-infected individuals in Vietnam. Microbes and infection. 2018.10; 21 (2): 113-118. ( PubMed, DOI )

Natsuko Inagaki, Takeharu Hayashi, Yasuyoshi Takei, Kousuke Tanimoto, Taishiro Chikamori, Akinori Kimura. Clinical and genetic backgrounds of hypertrophic cardiomyopathy with mid-ventricular obstruction. J. Hum. Genet.. 2018.09; ( PubMed, DOI )

Hayashi Takeharu, Tanimoto Kousuke, Hirayama-Yamada Kayoko, Tsuda Etsuko, Ayusawa Mamoru, Nunoda Shinichi, Hosaki Akira, Kimura Akinori. Genetic background of Japanese patients with pediatric hypertrophic and restrictive cardiomyopathy Journal of Human Genetics. 2018.09; 63 (9): 989-996. ( ichushi )

Rie Murayama, Mariko Kimura-Asami, Marina Togo-Ohno, Yumiko Yamasaki-Kato, Taeko K Naruse, Takeshi Yamamoto, Takeharu Hayashi, Tomohiko Ai, Katherine G Spoonamore, Richard J Kovacs, Matteo Vatta, Mai Iizuka, Masumi Saito, Shotaro Wani, Yuichi Hiraoka, Akinori Kimura, Hidehito Kuroyanagi. Phosphorylation of the RSRSP stretch is critical for splicing regulation by RNA-Binding Motif Protein 20 (RBM20) through nuclear localization. Sci Rep. 2018.06; 8 (1): 8970. ( PubMed, DOI )

Takeharu Hayashi, Kousuke Tanimoto, Kayoko Hirayama-Yamada, Etsuko Tsuda, Mamoru Ayusawa, Shinichi Nunoda, Akira Hosaki, Akinori Kimura. Genetic background of Japanese patients with pediatric hypertrophic and restrictive cardiomyopathy. J. Hum. Genet.. 2018.06; ( PubMed, DOI )

An Jianbo, Naruse Taeko K., Kimura Akinori. MKL1 Affects Proliferation/Survival Property of Pro-Atherogenic Macrophages ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018.05; 38 ( DOI )

Tsujii Nobuyuki, Hayashi Takeharu, Hayashi Tamaki, Kimura Akinori, Nishikubo Toshiya. Barth syndrome associated with triple mutation(和訳中) Pediatrics International. 2018.04; 60 (4): 385-387. ( ichushi )

Nobuyuki Tsujii, Takeharu Hayashi, Tamaki Hayashi, Akinori Kimura, Toshiya Nishikubo. Barth syndrome associated with triple mutation. Pediatr Int. 2018.03; ( PubMed, DOI )

Tomokazu Yamaguchi, Takashi Suzuki, Teruki Sato, Akinori Takahashi, Hiroyuki Watanabe, Ayumi Kadowaki, Miyuki Natsui, Hideaki Inagaki, Satoko Arakawa, Shinji Nakaoka, Yukio Koizumi, Shinsuke Seki, Shungo Adachi, Akira Fukao, Toshinobu Fujiwara, Tohru Natsume, Akinori Kimura, Masaaki Komatsu, Shigeomi Shimizu, Hiroshi Ito, Yutaka Suzuki, Josef M Penninger, Tadashi Yamamoto, Yumiko Imai, Keiji Kuba. The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Sci Signal. 2018.02; 11 (516): ( PubMed, DOI )

Takuro Arimura, Antoine Muchir, Masayoshi Kuwahara, Sachio Morimoto, Taisuke Ishikawa, Cheng-Kun Du, Dong-Yun Zhan, Shu Nakao, Noboru Machida, Ryo Tanaka, Yoshihisa Yamane, Takeharu Hayashi, Akinori Kimura. Overexpression of heart-specific small subunit of myosin light chain phosphatase results in heart failure and conduction disturbance. Am. J. Physiol. Heart Circ. Physiol.. 2018.02; ( PubMed, DOI )

Haruhito Harada, Takeharu Hayashi, Hirofumi Nishi, Ken Kusaba, Yoshinori Koga, Yasutoshi Koga, Ikuya Nonaka, Akinori Kimura. Phenotypic expression of a novel desmin gene mutation: hypertrophic cardiomyopathy followed by systemic myopathy. J. Hum. Genet.. 2018.02; 63 (2): 249-254. ( PubMed, DOI )

Harada Haruhito, Hayashi Takeharu, Nishi Hirofumi, Kusaba Ken, Koga Yoshinori, Koga Yasutoshi, Nonaka Ikuya, Kimura Akinori. Phenotypic expression of a novel desmin gene mutation: hypertrophic cardiomyopathy followed by systemic myopathy Journal of Human Genetics. 2018.02; 63 (2): 249-254. ( ichushi )

Watanabe T, Kimura A, Kuroyanagi H. Alternative Splicing Regulator RBM20 and Cardiomyopathy. Frontiers in molecular biosciences. 2018; 5 105. ( PubMed, DOI )

Naruse TK, Akari H, Matano T, Kimura A. Diversity of ULBP5 in Old-World monkeys (Cercopithecidae) and divergence of the ULBP gene family in primates. Proceedings of the Japan Academy. Series B, Physical and biological sciences. 2018; 94 (10): 441-453. ( PubMed, DOI )

Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K Naruse, Mamoru Watanabe, Akinori Kimura. MKL1 expressed in macrophages contributes to the development of murine colitis. Sci Rep. 2017.10; 7 (1): 13650. ( PubMed, DOI )

Sayuri Seki, Takushi Nomura, Masako Nishizawa, Hiroyuki Yamamoto, Hiroshi Ishii, Saori Matsuoka, Teiichiro Shiino, Hironori Sato, Kazuta Mizuta, Hiromi Sakawaki, Tomoyuki Miura, Taeko K Naruse, Akinori Kimura, Tetsuro Matano. In vivo virulence of MHC-adapted AIDS virus serially-passaged through MHC-mismatched hosts. PLoS Pathog.. 2017.09; 13 (9): e1006638. ( PubMed, DOI )

Zhiyong Chen, Yan Wang, Masataka Kuwana, Xue Xu, Wei Hu, Xuebing Feng, Hong Wang, Akinori Kimura, Lingyun Sun. HLA-DRB1 Alleles as Genetic Risk Factors for the Development of Anti-MDA5 Antibodies in Patients with Dermatomyositis. J. Rheumatol.. 2017.09; 44 (9): 1389-1393. ( PubMed, DOI )

Teruki Sato, Chitose Sato, Ayumi Kadowaki, Hiroyuki Watanabe, Lena Ho, Junji Ishida, Tomokazu Yamaguchi, Akinori Kimura, Akiyoshi Fukamizu, Josef M Penninger, Bruno Reversade, Hiroshi Ito, Yumiko Imai, Keiji Kuba. ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage. Cardiovasc. Res.. 2017.06; 113 (7): 760-769. ( PubMed, DOI )

John M Gregson, Daniel F Freitag, Praveen Surendran, Nathan O Stitziel, Rajiv Chowdhury, Stephen Burgess, Stephen Kaptoge, Pei Gao, James R Staley, Peter Willeit, Sune F Nielsen, Muriel Caslake, Stella Trompet, Linda M Polfus, Kari Kuulasmaa, Jukka Kontto, Markus Perola, Stefan Blankenberg, Giovanni Veronesi, Francesco Gianfagna, Satu Männistö, Akinori Kimura, Honghuang Lin, Dermot F Reilly, Mathias Gorski, Vladan Mijatovic, , Patricia B Munroe, Georg B Ehret, , Alex Thompson, Maria Uria-Nickelsen, Anders Malarstig, Abbas Dehghan, , Thomas F Vogt, Taishi Sasaoka, Fumihiko Takeuchi, Norihiro Kato, Yoshiji Yamada, Frank Kee, Martina Müller-Nurasyid, Jean Ferrières, Dominique Arveiler, Philippe Amouyel, Veikko Salomaa, Eric Boerwinkle, Simon G Thompson, Ian Ford, J Wouter Jukema, Naveed Sattar, Chris J Packard, Abdulla Al Shafi Majumder, Dewan S Alam, Panos Deloukas, Heribert Schunkert, Nilesh J Samani, Sekar Kathiresan, , Børge G Nordestgaard, Danish Saleheen, Joanna Mm Howson, Emanuele Di Angelantonio, Adam S Butterworth, John Danesh, . Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles. Eur J Prev Cardiol. 2017.03; 24 (5): 492-504. ( PubMed, DOI )

Paku Yooki, Watanabe Masataka, Iwasaki Youichi, Kobayashi Masatake, Inagaki Natsuko, Hirayama Kayoko, Hayashi Takeharu, Kimura Akinori, Yamashina Akira. TTNフレームシフト変異が認められた拡張型心筋症の1症例(A TTN Frameshift Mutation Found in a Patient with Dilated Cardiomyopathy) 日本循環器学会学術集会抄録集. 2017.03; 81回 SS07-6. ( ichushi )

Inagaki Natsuko, Hayashi Takeharu, Takei Yasuyoshi, Chikamori Taishiro, Yamashina Akira, Kimura Akinori. 心室中部閉塞型肥大型心筋症の遺伝子解析(Genetic Analysis of Hypertrophic Cardiomyopathy with Mid-ventricular Obstruction Phenotype) 日本循環器学会学術集会抄録集. 2017.03; 81回 PE-429. ( ichushi )

Eri Kikkawa, Masafumi Tanaka, Taeko K Naruse, Tomi T Tsuda, Michio Tsuda, Koichi Murata, Akinori Kimura. Diversity of MHC class I alleles in Spheniscus humboldti. Immunogenetics. 2017.02; 69 (2): 113-124. ( PubMed, DOI )

Sumire Iseda, Naofumi Takahashi, Hugo Poplimont, Takushi Nomura, Sayuri Seki, Taku Nakane, Midori Nakamura, Shoi Shi, Hiroshi Ishii, Shota Furukawa, Shigeyoshi Harada, Taeko K Naruse, Akinori Kimura, Tetsuro Matano, Hiroyuki Yamamoto. Biphasic CD8+ T-Cell Defense in Simian Immunodeficiency Virus Control by Acute-Phase Passive Neutralizing Antibody Immunization. J. Virol.. 2016.07; 90 (14): 6276-6290. ( PubMed, DOI )

Hideki Kawai, Shin-Ichiro Morimoto, Yoko Takakuwa, Akihiro Ueda, Ken-Ichi Inada, Masayoshi Sarai, Takuro Arimura, Tatsuro Mutoh, Akinori Kimura, Yukio Ozaki. Hypertrophic Cardiomyopathy Accompanied by Spinocerebellar Atrophy With a Novel Mutation in Troponin I Gene. Int Heart J. 2016.07; 57 (4): 507-510. ( PubMed, DOI )

Hiroshi Ishii, Saori Matsuoka, Takushi Nomura, Midori Nakamura, Teiichiro Shiino, Yuko Sato, Naoko Iwata-Yoshikawa, Hideki Hasegawa, Kazuta Mizuta, Hiromi Sakawaki, Tomoyuki Miura, Yoshio Koyanagi, Taeko K Naruse, Akinori Kimura, Tetsuro Matano. Association of lymph-node antigens with lower Gag-specific central-memory and higher Env-specific effector-memory CD8(+) T-cell frequencies in a macaque AIDS model. Sci Rep. 2016.07; 6 30153. ( PubMed, DOI )

Masayoshi Oikawa, Nobuo Sakamoto, Atsushi Kobayashi, Satoshi Suzuki, Akiomi Yoshihisa, Takayoshi Yamaki, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-Ichi Saitoh, Yuichirou Kiko, Hajime Nakano, Takeharu Hayashi, Akinori Kimura, Yasuchika Takeishi. Familial hypertrophic obstructive cardiomyopathy with the GLA E66Q mutation and zebra body. BMC Cardiovasc Disord. 2016.05; 16 83. ( PubMed, DOI )

Taeko K Naruse, Daisuke Sakurai, Hitoshi Ohtani, Gaurav Sharma, Surendra K Sharma, Madhu Vajpayee, Narinder K Mehra, Gurvinder Kaur, Akinori Kimura. APOBEC3H polymorphisms and susceptibility to HIV-1 infection in an Indian population. J. Hum. Genet.. 2016.03; 61 (3): 263-265. ( PubMed, DOI )

Toshihiro Tanaka, Akinori Kimura. Cardiovascular genetics. J. Hum. Genet.. 2016.01; 61 (1): 1. ( PubMed, DOI )

Akinori Kimura. Molecular genetics and pathogenesis of cardiomyopathy. J. Hum. Genet.. 2016.01; 61 (1): 41-50. ( PubMed, DOI )

Takushi Nomura, Hiroyuki Yamamoto, Hiroshi Ishii, Hirofumi Akari, Taeko K Naruse, Akinori Kimura, Tetsuro Matano. Broadening of Virus-Specific CD8+ T-Cell Responses Is Indicative of Residual Viral Replication in Aviremic SIV Controllers. PLoS Pathog.. 2015.11; 11 (11): e1005247. ( PubMed, DOI )

Akiko Koizumi, Tetsuo Sasano, Wataru Kimura, Yoshihiro Miyamoto, Takeshi Aiba, Taisuke Ishikawa, Akihiko Nogami, Seiji Fukamizu, Harumizu Sakurada, Yoshihide Takahashi, Hiroaki Nakamura, Tomoyuki Ishikura, Haruhiko Koseki, Takuro Arimura, Akinori Kimura, Kenzo Hirao, Mitsuaki Isobe, Wataru Shimizu, Naoyuki Miura, Tetsushi Furukawa. Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias. Eur. Heart J.. 2015.10; ( PubMed, DOI )

Chika Kadota, Takuro Arimura, Takeharu Hayashi, Taeko K Naruse, Sachio Kawai, Akinori Kimura. Screening of sarcomere gene mutations in young athletes with abnormal findings in electrocardiography: identification of a MYH7 mutation and MYBPC3 mutations. J. Hum. Genet.. 2015.10; 60 (10): 641-645. ( PubMed, DOI )

Daisuke Sakurai, Yasumasa Iwatani, Hitoshi Ohtani, Taeko K Naruse, Hiroshi Terunuma, Wataru Sugiura, Akinori Kimura. APOBEC3H polymorphisms associated with the susceptibility to HIV-1 infection and AIDS progression in Japanese. Immunogenetics. 2015.04; 67 (4): 253-257. ( PubMed, DOI )

Taisuke Ishikawa, Chuanchau J Jou, Akihiko Nogami, Shinya Kowase, Cammon B Arrington, Spencer M Barnett, Daniel T Harrell, Takuro Arimura, Yukiomi Tsuji, Akinori Kimura, Naomasa Makita. Novel mutation in the α-myosin heavy chain gene is associated with sick sinus syndrome. Circ Arrhythm Electrophysiol. 2015.04; 8 (2): 400-408. ( PubMed, DOI )

Atsushi Tanaka, Shinsuke Yuasa, Giulia Mearini, Toru Egashira, Tomohisa Seki, Masaki Kodaira, Dai Kusumoto, Yusuke Kuroda, Shinichiro Okata, Tomoyuki Suzuki, Taku Inohara, Takuro Arimura, Shinji Makino, Kensuke Kimura, Akinori Kimura, Tetsushi Furukawa, Lucie Carrier, Koichi Node, Keiichi Fukuda. Endothelin-1 induces myofibrillar disarray and contractile vector variability in hypertrophic cardiomyopathy-induced pluripotent stem cell-derived cardiomyocytes. J Am Heart Assoc. 2014.11; 3 (6): e001263. ( PubMed, DOI )

Naomasa Makita, Nobue Yagihara, Lia Crotti, Christopher N Johnson, Britt-Maria Beckmann, Michelle S Roh, Daichi Shigemizu, Peter Lichtner, Taisuke Ishikawa, Takeshi Aiba, Tessa Homfray, Elijah R Behr, Didier Klug, Isabelle Denjoy, Elisa Mastantuono, Daniel Theisen, Tatsuhiko Tsunoda, Wataru Satake, Tatsushi Toda, Hidewaki Nakagawa, Yukiomi Tsuji, Takeshi Tsuchiya, Hirokazu Yamamoto, Yoshihiro Miyamoto, Naoto Endo, Akinori Kimura, Kouichi Ozaki, Hideki Motomura, Kenji Suda, Toshihiro Tanaka, Peter J Schwartz, Thomas Meitinger, Stefan Kääb, Pascale Guicheney, Wataru Shimizu, Zahurul A Bhuiyan, Hiroshi Watanabe, Walter J Chazin, Alfred L George. Novel calmodulin mutations associated with congenital arrhythmia susceptibility. Circ Cardiovasc Genet. 2014.08; 7 (4): 466-474. ( PubMed, DOI )

Seigo Okada, Yasuo Suzuki, Takuro Arimura, Akinori Kimura, Hiroko Narumi, Shunji Hasegawa. A novel de novo mutation of β-cardiac myosin heavy chain gene found in a twelve-year-old boy with hypertrophic cardiomyopathy. J. Genet.. 2014.08; 93 (2): 557-560. ( PubMed )

Takushi Nomura, Hiroyuki Yamamoto, Naofumi Takahashi, Taeko K Naruse, Akinori Kimura, Tetsuro Matano. Identification of SIV Nef CD8(+) T cell epitopes restricted by a MHC class I haplotype associated with lower viral loads in a macaque AIDS model. Biochem. Biophys. Res. Commun.. 2014.07; 450 (2): 942-947. ( PubMed, DOI )

Pinós T, Fuku N, Cámara Y, Arai Y, Abe Y, Rodríguez-Romo G, Garatachea N, Santos-Lozano A, Miro-Casas E, Ruiz-Meana M, Otaegui I, Murakami H, Miyachi M, Garcia-Dorado D, Hinohara K, Andreu AL, Kimura A, Hirose N, Lucia A. The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts. Age (Dordr). 2014.04; 36 (2): 933-943. ( PubMed, DOI )

Akinori Kimura. Departure from the Hardy-Weinberg equilibrium. Gene. 2014.03; 537 (2): 357. ( PubMed, DOI )

Taeko K Naruse, Hirofumi Akari, Tetsuro Matano, Akinori Kimura. Divergence and diversity of ULBP2 genes in rhesus and cynomolgus macaques. Immunogenetics. 2014.03; 66 (3): 161-170. ( PubMed, DOI )

Goro Katsuumi, Wataru Shimizu, Hiroshi Watanabe, Takashi Noda, Akihiko Nogami, Kimie Ohkubo, Takeru Makiyama, Naofumi Takehara, Yuichiro Kawamura, Yukio Hosaka, Masahito Sato, Satoki Fukae, Masaomi Chinushi, Hirotaka Oda, Masaaki Okabe, Akinori Kimura, Koji Maemura, Ichiro Watanabe, Shiro Kamakura, Minoru Horie, Yoshifusa Aizawa, Naomasa Makita, Tohru Minamino. Efficacy of bepridil to prevent ventricular fibrillation in severe form of early repolarization syndrome. Int. J. Cardiol.. 2014.03; 172 (2): 519-522. ( PubMed, DOI )

Ayako Nishio, Yoshihiro Noguchi, Tatsuya Sato, Taeko K Naruse, Akinori Kimura, Akira Takagi, Ken Kitamura. A DFNA5 mutation identified in Japanese families with autosomal dominant hereditary hearing loss. Ann. Hum. Genet.. 2014.03; 78 (2): 83-91. ( PubMed, DOI )

Nami Iwamoto, Naofumi Takahashi, Sayuri Seki, Takushi Nomura, Hiroyuki Yamamoto, Makoto Inoue, Tsugumine Shu, Taeko K Naruse, Akinori Kimura, Tetsuro Matano. Control of simian immunodeficiency virus replication by vaccine-induced Gag- and Vif-specific CD8+ T cells. J. Virol.. 2014.01; 88 (1): 425-433. ( PubMed, DOI )

Teruki Sato, Takashi Suzuki, Hiroyuki Watanabe, Ayumi Kadowaki, Akiyoshi Fukamizu, Peter P Liu, Akinori Kimura, Hiroshi Ito, Josef M Penninger, Yumiko Imai, Keiji Kuba. Apelin is a positive regulator of ACE2 in failing hearts. J. Clin. Invest.. 2013.12; 123 (12): 5203-5211. ( PubMed, DOI )

Takuro Arimura, Ryu Takeya, Taisuke Ishikawa, Tetsuhiro Yamano, Akiko Matsuo, Tetsuya Tatsumi, Tetsuya Nomura, Hideki Sumimoto, Akinori Kimura. Dilated cardiomyopathy-associated FHOD3 variant impairs the ability to induce activation of transcription factor serum response factor. Circ. J.. 2013.12; 77 (12): 2990-2996. ( PubMed )

Takuro Arimura, Kenji Onoue, Yumiko Takahashi-Tanaka, Taisuke Ishikawa, Masayoshi Kuwahara, Mitsutoshi Setou, Shuji Shigenobu, Katsushi Yamaguchi, Anne T Bertrand, Noboru Machida, Kazumi Takayama, Masayuki Fukusato, Ryo Tanaka, Satoshi Somekawa, Tomoya Nakano, Yoshihisa Yamane, Keiji Kuba, Yumiko Imai, Yoshihiko Saito, Gisèle Bonne, Akinori Kimura. Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations. Cardiovasc. Res.. 2013.08; 99 (3): 382-394. ( PubMed, DOI )

Claudia Crocini, Takuro Arimura, Silke Reischmann, Alexandra Eder, Ingke Braren, Arne Hansen, Thomas Eschenhagen, Akinori Kimura, Lucie Carrier. Impact of ANKRD1 mutations associated with hypertrophic cardiomyopathy on contraction parameters of engineered heart tissue. Basic Res. Cardiol.. 2013.05; 108 (3): 349. ( PubMed, DOI )

Kashiwakura Yuji, Sakurai Daisuke, Kanno Yumiko, Hashiguchi Masaaki, Kobayashi Ayano, Kurosu Akira, Tokudome Shogo, Kobata Tetsuji, Kojima Hidefumi. CD2-mediated regulation of peripheral CD4(+) CD25(+) regulatory T-cell apoptosis accompanied by down-regulation of Bim. Immunology. 2013.05; 139 (1): 48-60. ( PubMed, DOI )

An J, Kimura A. IkBL mapped within the HLA region is a novel regulator of alternative splicing involved in the pathogenesis of immune-related diseases. MHC. 2013; 20 (3): 191-197.

Nakayama EE, Nakajima T, Kaur G, Miyama J, Terunuma H, Mehra NK, Kimura A, Shioda T. A naturally occurring single amino acid substitution in human TRIM5a linker region affects its anti-HIV-1 activity and susceptibility to HIV-1 infection. AIDS Res Hum Retroviruses. 2013; 29 (6): 919-924. ( PubMed, DOI )

Sakurai Daisuke, Zhao Jian, Deng Yun, Kelly Jennifer A, Brown Elizabeth E, Harley John B, Bae Sang-Cheol, Alarcomicronn-Riquelme Marta E, Edberg Jeffrey C, Kimberly Robert P, Ramsey-Goldman Rosalind, Petri Michelle A, Reveille John D, Vila Luis M, Alarcon Graciela S, Kaufman Kenneth M, Vyse Timothy J, Jacob Chaim O, Gaffney Patrick M, Sivils Kathy Moser, James Judith A, Kamen Diane L, Gilkeson Gary S, Niewold Timothy B, Merrill Joan T, Scofield R Hal, Criswell Lindsey A, Stevens Anne M, Boackle Susan A, Kim Jae-Hoon, Choi Jiyoung, Pons-Estel Bernardo A, Freedman Barry I, Anaya Juan-Manuel, Martin Javier, Yu C Yung, Chang Deh-Ming, Song Yeong Wook, Langefeld Carl D, Chen Weiling, Grossman Jennifer M, Cantor Rita M, Hahn Bevra H, Tsao Betty P, BIOLUPUS and GENLES networks. Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression. PLoS Genet. 2013; 9 (10): e1003870. ( PubMed, DOI )

Deng Yun, Zhao Jian, Sakurai Daisuke, Kaufman Kenneth M, Edberg Jeffrey C, Kimberly Robert P, Kamen Diane L, Gilkeson Gary S, Jacob Chaim O, Scofield R Hal, Langefeld Carl D, Kelly Jennifer A, Ramsey-Goldman Rosalind, Petri Michelle A, Reveille John D, Vila Luis M, Alarcon Graciela S, Vyse Timothy J, Pons-Estel Bernardo A, Freedman Barry I, Gaffney Patrick M, Sivils Kathy Moser, James Judith A, Gregersen Peter K, Anaya Juan-Manuel, Niewold Timothy B, Merrill Joan T, Criswell Lindsey A, Stevens Anne M, Boackle Susan A, Cantor Rita M, Chen Weiling, Grossman Jeniffer M, Hahn Bevra H, Harley John B, Alarcomicronn-Riquelme Marta E, Brown Elizabeth E, Tsao Betty P, Argentine Collaborative Group. MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus. PLoS Genet. 2013; 9 (2): e1003336. ( PubMed, DOI )

Ichihara S, Yamamoto K, Asano H, Nakatochi M, Sukegawa M, Ichihara G, Izawa H, Hirashiki A, Takatsu MF, Umeda H, Iwase M, Inagaki H, Hirayama H, Sone T, Nishigaki K, Minatoguchi S, Cho MC, Jang Y, Kim HS, Park JE, Tada-Oikawa S, Kitajima H, Matsubara T, Sunagawa K, Shimokawa H, Kimura A, Lee JY, Murohara T, Inoue I, Yokota M. Identification of a glutamic acid repeat polymorphism of ALMS1 as a novel genetic risk marker for early-onset myocardial infarction by genome-wide linkage analysis. Circ Cardiovasc Genet.. 2013; 6 (6): 569-578. ( PubMed, DOI )

An J, Nakajima T, Shibata H, Arimura T, Yasunami M, Kimura A.. A novel link of HLA locus to the regulation of immunity and infection: NFKBIL1 regulates alternative splicing of human immune-related genes and influenza virus M gene. J Autoimmun. 2013; In Press. ( PubMed, DOI )

Chan K, Patel RS, Newcombe P, Nelsone CP, Qasim A, Epstein SE, Burnett S, Vaccarino V, Zafari AM, Shah SH, Anderson JL, Carlquist JF, Hartiala J, Allayee H, Hinohara K, Lee BS, Erl A, Ellis KL, Goel A, Schaefer AS, Eddine N, Mokhtari NEE, Goldstein BA, Hlatky MA, Go AS, Shen GQ, Gong Y, Pepine C, Laxton RC, Wittaker JC, Tang WHW, Johnson JA, Wang QK, Assimes TL, Nöthlings U, Farrall M, Watkins H, Richards MA, Cameron VA, Muendlein A, Drexel H, Koch W, Park JE, Kimura A, Shen WF, Simpson IA, Hazen SL, Horne BD, Hauser ER, Quyyumi AA, Reilly MP, Samani NJ, Ye S. Association between the chromosome 9p21 locus and angiographic coronary artery disease burden - a collaborative meta-analysis. J Am Col Cardiol.. 2013; 61 (9): 957-970. ( PubMed, DOI )

Sharma G, Ohtani H, Kaur G, Naruse TK, Sharma SK, Vajpayee M, KimuraA, Mehra NK. Status of TIM-1 exon 4 haplotypes and CD4+T cell counts in HIV-1 seroprevalent North Indians. Hum Immunol. 2013; 74 (2): 163-165. ( PubMed, DOI )

Takahashi N, Nomura T, Takahara Y, Yamamoto H, Shiino T, Takeda A, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Sakawaki H, Miura T, Igarashi T, Koyanagi Y, Naruse TK, Kimura A, Matano T. A novel protective MHC-I haplotype not associated with dominant Gag-specific CD8+ T-cell responses in SIVmac239 infection of Burmese rhesus macaques. PLos ONE. 2013; 8 (1): e54300. ( PubMed, DOI )

Ishikawa T, Takahashi N, Ohno S, Sakurada H, Nakamura K, On YK, Park JE, Makiyama T, Horie M, Arimura T, Makita N, Kimura A. Novel SCN3B mutation associated with Brugada syndrome affects intracellular trafficking and function of Nav1.5. Circ J. 2013; 77 (4): 959-967. ( PubMed, DOI )

Nakane T, Nomura T, Shi S, Nakamura M, Naruse TK, Kimura A, Matano T, Yamamoto H. Limited impact of passive non-neutralizing antibody immunization in acute SIV infection on viremia control in rhesus macaques. PLoS ONE. 2013; 8 (9): e73453. ( PubMed, DOI )

Terao C, Yoshifuji H, Kimura A, Matsumura T, Ohmura K, Takahashi M, Shimizu M, Kawaguchi T, Chen Z, Naruse TK, Sato-Otubo A, Ebana Y, Maejima Y, Kinoshita H, Murakami K, Kawabata D, Wada Y, Narita I, Tazaki J, Kawaguchi Y, Yamanaka H, Yurugi K, Miura Y, Maekawa T, Ogawa S, Komuro I, Nagai1 R, Yamada R, Tabara Y, Isobe M, Mimori T, Matsuda F.. Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population. Am J Hum Genet. 2013; 93 (2): 289-297. ( PubMed, DOI )

Terao C, Yoshifuji H, Ohmura K, Murakami K, Kawabata D, Yurugi K, Tazaki J, Kinoshita H, Kimura A, Akizuki M, Kawaguchi Y, Yamanaka H, Miura Y, Maekawa T, Saji H, Mimori T, Matsuda F. Association of Takayasu arteritis with HLA-B*67:01 and two amino acids in HLA-B protein. Rheumatol. 2013; 52 (10): 1769-1774. ( PubMed, DOI )

Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Sato M, Hosaka Y, Fukae S, Chinushi M, Oda H, Okabe H, Kimura A, Maemura K, Watanabe I, Kamakura S, Aizawa Y, Shimizu W, Makita N. Similarities and differences in genetic and clinical characteristics between early repolarization syndrome and Brugada syndrome. Circ Arrhythm Electrophysiol. 2012; 5 (2): e60-e61. ( DOI )

Xi Y, Ai T, De Lange E, Li Z, Wu G, Brunelli L, Kyle WB, Cheng J, Ackerman MJ, Kimura A, Weiss JN, Qu Z, Kim JJ, Faulkner G, Vatta M. Loss-of-function of hNav1.5 by ZASP1-D117N associated with intraventricular conduction disturbances in left ventricular noncompaction. Circ Arrhythm Electrophysiol. 2012; 5 (5): 1017-1026. ( PubMed, DOI )

Sato A, Sakamoto N, Ando K, Kaneshiro T, Uekita H, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Sato M, Tamagawa K, Arimura T, Kimura A, Takeishi Y. Dilated phase of hypertrophic cardiomyopathy caused by two different sarcomere mutations, treated with surgical left ventricular reconstruction and cardiac resynchronization therapy with a defibrillator. Intern Med. 2012; 51 (18): 2559-2564. ( PubMed, DOI )

Minami T, Kuwahara K, Nakagawa Y, Takaoka M, Kinoshita H, Nakao K, Kuwabara Y, Yamada Y, Yamada C, Shibata J, Usami S, Yasuno S, Nishikimi T, Ueshima K, Sata M, Nakano H, Seno T, Kawahito Y, Sobue K, Kimura A, Nagai R, Nakao K. Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodeling in mice. EMBO J. 2012; 31 (23): 4428-4440. ( PubMed, DOI )

Ishikawa T, Sato A, Marcou CA, Tester DJ, Ackerman MJ, Crotti L, Schwartz PJ, On YK, Park JE, Nakamura K, Hiraoka M, Nakazawa K, Sakurada H, Arimura T, Makita N, Kimura A. A novel disease gene for Brugada syndrome: sarcolemmal membrane-associated protein gene mutations impair intracellular trafficking of hNav1.5. Circ Arrhythm Electrophysiol. 2012; 5 (6): 1098-1107. ( PubMed, DOI )

Tabara Y, Kohara K, Miki T; Millennium Genome Project for Hypertension (Fujioka A, Hanada H, Hata A, Hirawa N, Hiura Y, Imai Y, Inoko H, Itoh N, Iwai N, Kulski JK, Kamide K, Kato N, Osaka TK, Kawamoto R, Kawano Y, Kimura A, Kita Y, Kohara K, Kokubo Y, Mano H, Mano S, Miki T, Miyata T, Mizuki N, Morisaki T, Nakamura Y, Nakao K, Nakayama T, Nakura J, Ogawa M, Ogihara T, Ohkubo T, Ohno S, Oka A, Okamura T, Saruta T, Sekine A, Shiwa T, Soma M, Sugano S, Tabara Y, Tajima A, Takahashi N, Takashima N, Takeuchi F, Tokunaga K, Tomoike H, Umemura S, Yamane T, Yanai K, Yasunami M, Yatsu K, Yoshida T, Tabara Y). Hunting for genes for hypertension: the Millennium Genome Project for Hypertension. Hypertension Res. 2012; 35 (6): 567-573. ( PubMed, DOI )

Ohtani H, Naruse TK, Iwasaki Y, Ishida T, Akari H, Matano T, Kimura A. Lineage-specific evolution of T-cell immunoglobulin and mucin domain 1 gene in the primates. Immunogenetics. 2012; 64 (9): 669-678. ( PubMed, DOI )

Purevjav E, Arimura T, Augustin S, Huby A-C, Takagi K, Nunoda S, Kearney DL, Taylor MD, Terasaki F, Bos JM, Ommen SR, Shibata H, Takahashi M, Itoh-Satoh M, McKenna W, Murphy RT, Labeit S, Yamanaka Y, Machida N, Park JE, Alexander PMA, Weintraub RG, Kitaura Y, Ackerman MJ, Kimura A, Towbin JA. Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations. Hum Mol Genet. 2012; 21 (9): 2039-2053. ( PubMed, DOI )

Saito Y, Naruse TK, Akari H, Matano T, Kimura A. Diversity of MHC class I haplotypes in cynomolgus macaques. Immunogenetics. 2012; 62 (2): 131-141. ( PubMed, DOI )

Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizawa Y, Shimizu W, Naomasa Makita N. Clinical characteristics and risk of arrhythmia recurrences in patients with idiopathic ventricular fibrillation associated with early repolarization. Int J Cardiol. 2012; 159 (3): 238-240. ( PubMed, DOI )

Otsuka H, Arimura T, Abe T, Kawai H, Aizawa Y, Kubo T, Kitaoka H, Nakamura H, Nakamura K, Okamoto H, Ichida F, Ayusawa M, Nunoda S, Isobe M, Matsuzaki M, Doi YL, Fukuda K, Sasaoka T, Izumi T, Ashizawa N, Kimura A. Prevalence and distribution of sarcomeric gene mutations in Japanese patients with familial hypertrophic cardiomyopathy. Circ J. 2012; 76 (2): 453-461. ( PubMed, DOI )

Nomura T, Terahara K, Yamamoto H, Shiino T, Takahashi N, Nakane T, Iwamoto N, Ishii H, Tsukamoto T, Kawada M, Matsuoka S, Takeda A, Terahara K, Tsunetsugu-Yokota Y, Iwata-Yoshikawa N, Hasegawa H, Sata T, Naruse TK, Kimura A, Matano T. Association of major histocompatibility complex class I haplotypes with disease progression after simian immunodeficiency virus challenge in Burmese rhesus macaques. J Virol.. 2012; 86 (12): 6481-6490. ( PubMed, DOI )

Ishii H, Kawada M, Tsukamoto T, Yamamoto H, Matsuoka S, Shiino T, Takeda A, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Naruse TK, Kimura A, Takiguchi M, Matano T. Impact of vaccination on cytotoxic T lymphocyte immunodominance and cooperation against simian immunodeficiency virus replication in rhesus macaques. J Virol.. 2012; 86 (2): 738-745. ( PubMed, DOI )

Takaki A, Yamazaki A, Maekawa T, Shibata H, Hirayama K, Kimura A, Hirai H, Yasunami M. Positive selection of Toll-like receptor 2 polymorphisms in two closely related old world monkey species, rhesus and Japanese macaques. Immunogenetics. 2012; 64 (1): 15-29. ( PubMed, DOI )

Naruse TK, Okuda Y, Mori K, Akari H, Matano T, Kimura A. ULBP4/RAET1E is highly polymorphic in the Old World monkey. Immunogenetics. 2011; 63 (8): 501-509. ( PubMed, DOI )

Takahashi M, Chen Z, Watanabe K, Kobayashi H, Nakajima T, Kimura A, Izumi Y. Toll-like receptor 2 gene polymorphisms associated with aggressive periodontitis in Japanese. Open Dent J. 2011; 5 190-194. ( PubMed, DOI )

Takahara Y, Matsuoka S, Kuwano T, Tsukamoto T, Yamamoto H, Ishii H, Nakasone T, Takeda A, Inoue M, Iida A, Hara H, Shu T, Hasegawa M, Sakawaki H, Horiike M, Miura T, Igarashi T, Naruse TK, Kimura A, Matano T. Dominant induction of vaccine antigen-specific cytotoxic T lymphocyte responses after simian immunodeficiency virus challenge. Biochem Biophys Res Commun. 2011; 408 (4): 615-619. ( PubMed, DOI )

Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Sato M, Hosaka Y, Fukae S, Chinushi M, Oda H, Okabe H, Kimura A, Maemura K, Watanabe I, Kamakura S, Aizawa Y, Shimizu W, Makita N. Electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization. Circ Arrhythm Electrophysiol. 2011; 4 (6): 874-881. ( PubMed, DOI )

Ohtani H, Nakajima T, Akari H, Ishida T, KimuraA. Molecular evolution of immunoglobulin superfamily genes in primates. Immunogenetics. 2011; 63 (7): 417-428. ( PubMed, DOI )

Yanagimachi M, Miyamae T, Naruto T, Hara T, Kikuchi M, Hara R, Imagawa T, Mori M. Kaneko T, Goto H, Morita S, Mizuki N, Kimura A, Yokota S. Association of HLA-A*02:06 and DRB1*09:01 with clinical subtypes of juvenile idiopathic arthritis. J Hum Genet. 2011; 56 (3): 196-199. ( PubMed, DOI )

Kubo T, Kitaoka H, Okawa M, Baba Y, Hirota T, Hayato K, Yamasaki N, Matsumura Y, Otsuka H, Arimura T, Kimura A, Doi YL.. Genetic screening and double mutation in Japanese patients with hypertrophic cardiomyopathy. Circ J. 2011; 75 (11): 2654-2659. ( PubMed, DOI )

Kimura A. Contribution of genetic factors to the pathogenesis of dilated cardiomyopathy. Circ J. 2011; 75 (7): 1756-1765. ( PubMed, DOI )

Chen Z, Nakajima T, Inoue Y, Kudo T, Jibiki M, Iwai T, Kimura A. A single nucleotide polymorphism in the 3'-untranslated region of MyD88 gene is associated with Buerger disease but not with Takayasu arteritis in Japanese. J Hum Genet. 2011; 56 (7): 545-547. ( PubMed, DOI )

Arimura T, Ishikawa T, Nunoda S, Kawai S, Kimura A. Dilated cardiomyopathy-associated BAG3 mutations impair the Z-disc assembly and enhance the sensitivity to apoptosis in cardiomyocytes. Hum Mutat. 2011; 32 (12): 1481-1491. ( PubMed, DOI )

Nakamura M, Takahara Y, Ishii H, Sakawaki H, Horiike M, Miura T, Igarashi T, Naruse TK, Kimura A, Matano T, Matsuoka S. Major histocompatibility complex class I-restricted cytotoxic T lymphocyte responses during primary simian immunodeficiency virus infection in Burmese rhesus macaques. Microbiol Immuno. 2011; 55 (11): 768-773. ( PubMed, DOI )

Shuno Yasutaka, Tsuno Nelson H, Okaji Yurai, Tsuchiya Takeshi, Sakurai Daisuke, Nishikawa Takeshi, Yoshikawa Naoyuki, Sasaki Kazuhito, Hongo Kumiko, Tsurita Giichiro, Sunami Eiji, Kitayama Joji, Tokunaga Katsushi, Takahashi Koki, Nagawa Hirokazu. Id1/Id3 knockdown inhibits metastatic potential of pancreatic cancer. J Surg Res. 2010.06; 161 (1): 76-82. ( PubMed, DOI )

Kanno Yumiko, Sakurai Daisuke, Hase Hidenori, Kojima Hidefumi, Kobata Tetsuji. TACI induces cIAP1-mediated ubiquitination of NIK by TRAF2 and TANK to limit non-canonical NF-kappaB signaling. J Recept Signal Transduct Res. 2010.04; 30 (2): 121-132. ( PubMed, DOI )

Kojima Hidefumi, Kobayashi Ayano, Sakurai Daisuke, Kanno Yumiko, Hase Hidenori, Takahashi Riichi, Totsuka Yoshikazu, Semenza Gregg L, Sitkovsky Michail V, Kobata Tetsuji. Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow. J Immunol. 2010.01; 184 (1): 154-163. ( PubMed, DOI )

Arimura T, Sato R, Machida N, Bando H, Zhang DY, Morimoto S, Tanaka R, Yamane Y, Bonne G, Kimura A. Improvement of left ventricular dysfunction and of survival prognosis of dilated cardiomyopathy by administration of calcium sensitizer SCH00013 in a mouse model. J Am Coll Cardiol. 2010; 55 (14): 1503-1505. ( PubMed, DOI )

Purevjav E, Varela J, Morgado M, Kearney DL, Li H, Taylor MD, Arimura T, Moncman CL, McKenna W, Labeit S, Vatta M, Bowles NE, Kimura A, Boriek AM, Towbin JA. Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis. J Am Coll Cardiol. 2010; 56 (18): 1493-1502. ( PubMed, DOI )

Naruse TK, Chen Z, Yanagida R, Yamashita T, Saito Y, Mori K, Akari H, Yasutomi Y, Miyazawa M, Matano T, Kimura A. Diversity of MHC class I genes in Burmese-origin rhesus macaque. Immunogenetics. 2010; 62 (9): 601-611. ( PubMed, DOI )

Hitomi N, Kubo T, Kitaoka H, Hirota T, Hamada T, Hoshikawa E, Hayato K, Okawa M, Kimura A, Doi YL. A frameshift deletion mutation in the cardiac myosin-binding protein C gene was associated with dilated phase of hypertrophic cardiomyopathy and dilated cardiomyopathy. J Cardiol. 2010; 56 (2): 189-196. ( PubMed, DOI )

Neely1 GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmen L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NA, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks A, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM.. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell. 2010; 141 (1): 142-153. ( DOI )

Matuda S, Arimura T, Kimura A, Takekura H, Ohta S, Nakano K.. A novel protein found in the I bands of myofibrils is produced by alternative splicing of the DLST gene. Biochim Biophys Acta. 2010; 1800 (1): 31-39. ( PubMed, DOI )

Li Z, Ai T, Samani K, Xi Y, Tzeng HP, Xie M, Taylor MD, Wu S, Ge S, Dong JW. Cheng J, Ackerman MJ, Kimura A, Sinagra G, Brunelli L, Faulkner G, Vatta M.. ZASP missense mutation, S196L, leads to cytoskeletal and electrical abnormalities in a mouse model of cardiomyopathy. Circulation Arrhythm Electrophisiol. 2010; 3 (6): 646-656. ( PubMed, DOI )

Shichi D, Arimura T, Ishikawa T, Kimura A. Heart-specific small subunit of myosin light chain phosphatase activates Rho-associated kinase and regulates phosphorylation of myosin phosphatase target subunit 1. J Biol Chem. 2010; 285 (44): 33680-33690. ( PubMed, DOI )

Takahashi M, Kimura A. HLA and CTLA4 polymorphisms may confer a synergistic risk in the susceptibility to Graves disease. J Hum Genet. 2010; 55 (5): 323-326. ( PubMed, DOI )

Kimura A. Molecular basis of hereditary cardiomyopathy: abnormalities in calcium sensitivity, stretch response, stress response and beyond. J Hum Genet. 2010; 55 (2): 81-90. ( PubMed, DOI )

Wichukchinda N, Nakajima T, Saipradit N, Nakayama EE, Ohtani H, Rojanawiwat A, Pathipvanich P, Ariyoshi K, Sawanpanyalert P, Shioda T, Kimura A. TIM1 haplotype may control the disease progression to AIDS in a HIV-1-infected female cohort in Thailand. AIDS. 2010; 24 (11): 1625-1631. ( PubMed, DOI )

Sugimoto C, Watanabe S, Naruse T, Kajiwara E, Shiino T, Umano N, Ueda K, Sato H, Ohgimoto S, Hirsh V, Villinger F, Ansari AA, Kimura A, Miyazawa M, Suzuki Y, Yamamoto N, Nagai Y, Mori K. Protection of macaques with diverse MHC genotypes against a heterologous SIV by vaccination with a deglycosylated live-attenuated SIV. PLoS ONE. 2010; 5 (7): e11678. ( PubMed, DOI )

Choi JO, You CW, Nah JC, Park JR, Lee BS, Choi BY, Cho BY, Lee SC, Park SW, Kimura A, Park JE. Long-term outcome of four Korean families with hypertrophic cardiomyopathy caused by four different mutations. Clin Cardiol. 2010; 33 (7): 430-438. ( PubMed, DOI )

Chen Z, Nakajima T, Tanabe N, Hinohara K, Sakao S, Kasahara Y, Tatsumi K, Inoue Y, Kimura A. Susceptibility to chronic thromboembolic pulmonary hypertension may be conferred by miR-759 via its targeted interaction with polymorphic fibrinogen alpha gene. Hum Genet. 2010; 128 (4): 443-452. ( PubMed, DOI )

An J, Nakajima T, Kuba K, Kimura A. Losartan inhibits LPS-induced inflammatory signaling by PPAR-gamma-dependent mechanism in human THP-1 macrophage. Hypertension Res. 2010; 33 (8): 831-835. ( PubMed, DOI )

Itaya S, Nakajima T, Kaur G, Terunuma H, Ohtani H, Mehra N, Kimura A. No evidence of an association between the APOBEC3B deletion polymorphism and susceptibility to HIV infection and AIDS in Japanese and Indian populations. J Infect Dis. 2010; 202 (5): 815-816. ( PubMed, DOI )

Arimura T, Hayashi YK, Murakami T, Oya Y, Funabe S, Hirasawa EA, Hattori N, Nishino I, Kimura A. Mutational analysis of fukutin gene in dilated cardiomyopathy and hypertrophic cardiomyopathy. Circ J. 2009; 73 (1): 158-161. ( DOI )

Nakajima T, Nakayama EE, Kaur G, Terunuma H, Mimaya J, Ohtani H, Mehra N, Shioda Y, Kimura A. Impact of novel TRIM5alpha variants, Gly110Arg and G176del, on the anti-HIV-1 activity and the susceptibility to HIV-1 infection. AIDS. 2009; 23 (16): 2091-2100. ( PubMed, DOI )

Ueda K, Hirano Y, Higashiuesato Y, Aizawa Y, Hayashi T, Inagaki N, Tana T, Ohya Y, Takishita S, Muratani H, Hiraoka M, Kimura A. Role of HCN4 channel in preventing ventricular arrhythmia. J Hum Genet. 2009; 54 (2): 115-121. ( DOI )

Hinohara K, Ohtani H, Nakajima T, Sasaoka T, Sawabe M, Lee BS, Ban J, Park JE, Izumi T, Kimura A.. Validation of eight genetic risk factors in East Asian populations replicated the association of BRAP with coronary artery disease. J Hum Genet.. 2009; 54 (11): 642-646. ( PubMed, DOI )

Arimura T, Inagaki N, Hayashi T, Shichi D, Sato A, Hinohara K, Vatta M, Towbin JA, Chikamori T, Yamashina A, Kimura A. Impaired binding of ZASP/Cypher with phosphoglucomutase 1 is associated with dilated cardiomyopathy. Cardiovasc Res. 2009; 83 (1): 80-88. ( DOI )

Kominami S, Tanabe N, Ota M, Naruse T, Katsuyama Y, Nakanishi N, Tomoike H, Sakuma M, Shirato K, Takahashi M, Shibata H, Yasunami M, Chen Z, Kasahara Y, Tatsumi K, Kuriyama T, Kimura A. HLA-DPB1 and NFKBIL1 may confer the susceptibility to chronic thromboembolic pulmonary hypertension in the absence of deep vein thrombosis. J Hum Genet. 2009; 54 (2): 108-114. ( DOI )

Hinohara K, Nakajima T, Sasaoka T, Sawabe M, Lee BS, Ban J, Park JE, Izumi T, Kimura A. Replication studies for the association of PSMA6 polymorphism with coronary artery disease in East Asian populations. J Hum Genet. 2009; 54 (4): 248-251. ( DOI )

Hinohara K, Nakajima T, Sasaoka T, Sawabe M, Lee BS, Ban J, Park JE, Izumi T, Kimura A.. Validation of the association between AGTRL1 polymorphism and coronary artery disease in Japanese and Korean populations. J Hum Genet. 2009; 54 (9): 554-556. ( DOI )

Shichi D, Ota M, Katsuyama Y, Inoko H, Naruse T, Kimura A. Complex divergence at a microsatellite marker C1_2_5 in lineage of HLA-Cw/-B haplotype. J Hum Genet. 2009; 54 (4): 224-229. ( DOI )

Moulik M, Vatta M, Witt SH, Alora AM, Murphy RT, McKenna WJ, Boriek A, Oka K, Labeit S, Bowles NE, Arimura T, Kimura A, Towbin JA. ANKRD -the gene encoding cardiac ankyrin repeat protein- is a novel dilated cardiomyopathy gene. J Am Coll Cardiol. 2009; 54 (4): 325-333. ( PubMed, DOI )

Hinohara K, Nakajima T, Yasunami M, Houda S, Sasaoka T, Yamamoto K, Lee BS, Shibata H, Takahashi TY, Arimura T, Sato A, Naruse T, Ban J, Inoko H, Yamada Y, Sawabe M, Park JE,, Izumi T, Kimura A. Megakaryoblastic leukemia factor-1gene in the susceptibility to coronary artery disease. Hum Genet.. 2009; 126 (4): 539-547. ( PubMed, DOI )

Arimura T, Bos MJ, Sato A, Kubo T, Okamoto H, Nishi H, Harada H, Koga Y, Moulik M, Doi YL, Towbin JA, Ackerman MJ, Kimura A. Cardiac ankyrin repeat protein gene (ANKRD1) mutations in hypertrophic cardiomyopathy. J Am Coll Cardiol. 2009; 54 (4): 334-342. ( PubMed, DOI )

Kimura A. Does a gene polymorphism predisposing to the intermediate phenotype predict the risk of disease? Circ J. 2009; 73 (6): 1016-1017. ( PubMed, DOI )

Kano T, Mori T, Kimura A. Gender ratio distortion in abortuses and live births from patients with recurrent spontaneous abortion. Am J Reprod Immunol. 2009; 62 (3): 125-127. ( PubMed, DOI )

Sato A, Arimura T, Makita N, Ishikawa T, Aizawa Y, Ushinohama H, Aizawa Y, Kimura A.. Novel mechanisms of trafficking defect caused by KCNQ1 mutations found in long QT syndrome. J Biol Chem. 2009; 284 (50): 35122-35133. ( PubMed, DOI )

Hase Hidenori, Kanno Yumiko, Kojima Hidefumi, Sakurai Daisuke, Kobata Tetsuji. Coculture of osteoclast precursors with rheumatoid synovial fibroblasts induces osteoclastogenesis via transforming growth factor beta-mediated down-regulation of osteoprotegerin. Arthritis Rheum. 2008.11; 58 (11): 3356-3365. ( PubMed, DOI )

Hinohara K, Nakajima T, Takahashi M, Hohda S, Sasaoka T, Nakahara K, Chida K, Sawabe M, Arimura T, Sato A, Lee BS, Ban J, Yasunami M, Park JE, Izumi T, Kimura A. Replication of association between a chromosome 9p21 polymorphism with coronary artery disease in Japanese and Korean populations J Hum Genet. 2008; 53 (4): 357-359.

Nakajima T, Kimura A. Genetic factors which confer sensitivity to highly active antiretroviral therapy (HAART) in HIV-infected subjects - implication of a benefit of an earlier initiation of HAART in HIV therapy Pharmacogenomics. 2008; 9 (9): 1347-1351.

Kato N, Miyata T, Tabara Y, Katsuya T, Yanai K, Hanada H, Kamide K, Nakura J, Hohara K, Takeuchi F, Mano H, Yasunami M, Kimura A, Kita Y, Ueshima H, Nakamura T, Soma M, Hata A, Fujioka A, Kawano Y, Nakao K, Sekine A, Yoshida T, Nakamura Y, Saruta T, Ogihara T, Sugano S, Miki T, Tomoike H. High-density association study and nomination of susceptibility genes for hypertension in the Japanese national project Hum Mol Genet. 2008; 17 (4): 617-627.

Takemoto Y, Naruse TK, Namba K, Kitaichi N, Ota M, Shindo Y, Mizuki N, Gul A, Madanat W, Shams H, Davatchi F, Inoko H, Ohno S, Kimura A. Re-evaluation of heterogeneity in HLA-B510101 associated with Behcet's disease Tissue Antigens. 2008; 72 (4): 347-353.

Kimura A. Molecular etiology and pathogenesis of hereditary cardiomyopathy Circ J. 2008; 72 (Suppl A): A38-48.

Shichi D, Matsumori A, Naruse TK, Inoko H, Kimura A. HLA-DP beta chain may confer the susceptibility to hepatitis C virus-associated hypertrophic cardiomyopathy Int J Immunogenet. 2008; 35 (1): 37-43.

Tsukamoto T, Dohki S, Ueno T, Kawada M, Takeda A, Yasunami M, Naruse T, Kimura A, Takiguchi M, Matano T. Determination of a major histocompatibility complex class I restricting simian immunodeficiency virus Gag241-249 epitope AIDS. 2008; 22 (8): 993-994.

Nakajima T, Kaur G, Mehra NK, Kimura A. HIV-1/AIDS susceptibility and copy number variation in CCL3L1, a gene encoding a natural ligand for HIV-1 co-receptor CCR5. Cytogenet Genome Res. 2008; 123 (1-4): 156-160. ( DOI )

Nakajima T, Ohtani H, Satta Y, Uno Y, Akari H, Ishida T, Kimura A. Natural selection in the TLR-related genes in the course of primate evolution. Immunogenetics. 2008; 60 (12): 727-735. ( DOI )

Sakurai Daisuke, Hase Hidenori, Kanno Yumiko, Kojima Hidefumi, Okumura Ko, Kobata Tetsuji. TACI regulates IgA production by APRIL in collaboration with HSPG. Blood. 2007.04; 109 (7): 2961-2967. ( PubMed, DOI )

Sakurai Daisuke, Kanno Yumiko, Hase Hidenori, Kojima Hidefumi, Okumura Ko, Kobata Tetsuji. TACI attenuates antibody production costimulated by BAFF-R and CD40. Eur J Immunol. 2007.01; 37 (1): 110-118. ( PubMed, DOI )

Munehisa Y, Watanabe H, Kosaka T, Kimura A, Ito H. Successful outcome in a pregnant woman with isolated noncompaction of the left ventricular myocardium Intern Med. 2007; 46 (6): 285-289.

Aizawa Y, Mitsuma W, Ikrar T, Komura S, Hanawa H, Miyaima S, Miyoshi F, Kobayashi Y, Chinushi M, Kimura A, Hiraoka M, Aizawa Y. Human cardiac ryanodine receptor mutations in ion channel disorders in Japan Int J Cardiol. 2007; 116 (2): 263-265.

Takahashi-Tanaka Y, Yasunami M, Naruse T, Hinohara K, Matano T, Mori K, Miysazawa M, Honda M, Yasutomi Y, Nagai Y, Kimura A. Reference strand-mediated conformation analysis (RSCA)-based typing of multiple alleles in the rhesus macaque MHC class I Mamu-A and Mamu-B loci Electrophoresis. 2007; 28 (6): 918-924.

Yatsu K, Mizuki N, Hirata N, Oka A, Ito N, Yamane T, Ogawa M, Shiwa T, Tabara Y, Ohno S, Soma M, Hata A, Nakano K, Ueshima H, Ogiwara T, Tomoike H, Miki T, Kimura A, Mano S, Kulski JK, Umemura S, Inoko H. High-resolution mapping for essential hypertension using microsatellite markers Hypertension. 2007; 49 (3): 446-452.

Kuba K, Zhang L, Imai Y, Arab S, Chen M, Maekawa Y, Leschnik M, Leibbrabdt A, Makovic M, Schwaighofer J, Beetz N, Musialek R, Neely GG, Komnenoviv V, Kolm U, Metzler B, Ricci R, Hara H, Meixner A, Nghiem M, Chen X, Dawood F, Wong KM, Sarao R, Cukerman E, Kimura A, Hein L, Thalhammer J, Liu PP, Penninger JM. Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload Circ Res. 2007; 101 (4): e32-e42.

Nouchi T, Yasunami M, Mibu R, Yasunaga S, Itoh-Satoh M, Takahashi M, Tanaka S, Kuwano H, Kimura A. Somatic mutations leading to incomplete extinction of HLA class I were associated with replication error phenotype-positive colorectal carcinoma MHC. 2007; 13 (3): 187-197.

Knoell R, Postel R, Wang J, Kraetzner R, Hennecke G, Vacaru AM, Vakeel P, Schubert C, Murthy K, Rana BK, Dieter K, Gudrun K, Schaefer K, Hayashi T, Holm T, Kimura A, Schork N, Toliat MR, Nuemberg P, Schultheiss P, Schaper W, Schaper J, Bos E, Hertog JD, van Eeden F, Peters P, Hasenfuss G, Chien KR, Bakkers J. Laminin alpha 4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and in endothelial cells Circulation. 2007; 116 (5): 515-525.

Yamamoto H, Kawada M, Tsukamoto T, Takeda A, Igarashi H, Miyazawa M, Naruse T, Yasunami M, Kimura A, Matano T. Vaccine-based long-term stable control of simian-human immunodeficiency virus 89-6PD replication in rhesus macaques J Gen Virol. 2007; 88 (Pt2): 652-659.

Nakano N, Hori H, Abe M, Shibata H, Arimura T, Sasaoka T, Sawabe M, Chida K, Arai T, Nakahara K, Kubo T, Sugimoto K, Katsuya T, Ogihara T, Doi Y, Izumi T, Kimura A. Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy Am J Physiol Heart Card Physiol. 2007; 293 (6): H3396-H3403.

Maehata Y, Takamizawa S, Ozawa S, Izukuri K, Kato Y, Sato S, Lee MC, Kimura A, Hata R. Type III collagen is essential for growth acceleration of human osteoblastic cells by ascorbic acid 2-phosphate, a long-acting vitamin C derivative Matrix Biol. 2007; 26 (5): 371-381.

Arimura T, Hayashi T, Matsumoto Y, Shibata H, Hiroi S, Nakamura T, Inagaki N, Hinohara K, Takahashi M, Itoh-Satoh M, Bonne G, Schwartz K, Kimura A. Structural analysis of four and half LIM protein-2 in dilated cardiomyopathy Biochem Biophys Res Commun. 2007; 357 (1): 162-167.

Kano T, Mori T, Furudono M, Tamura I, Ishikawa H, Watanabe H, Kikkawa E, Warita T, Kawada H, Onizuka M, Takahashi M, Maeda Y, Naruse T, Inoko H, Kimura A. HLA may predict outcome of primary recurrent spontaneous abortion treated with paternal lymphocyte alloimmunization therapy Am J Reprod Immunol. 2007; 58 (4): 383-387.

Chen Z, Takahashi M, Naruse T, Nakajima T, Chen YW, Inoue Y, Ishilkawa I, Iwai T, Kimura A. Synergistic contribution of CD14 and HLA loci to the susceptibility to Buerger disease Hum Genet. 2007; 122 (3-4): 367-372.

Nakamura K, Katayama Y, Kusano KF, Haraoka K, Tani Y, Nagase S, Morita H, Miura D, Fujimoto Y, Furukawa T, Ueda K, Aizawa Y, Kimura A, Kurachi Y, Ohe T. Anti-KCNH2 Antibody-induced long QT syndrome: novel acquired form of long QT syndrome J Am Coll Cardiol. 2007; 50 (18): 1808-1809.

Aizawa Y, Ueda K, Scornik F, Cordeiro JM, Wu Y, Desai M, Guerchicoff A, Pollevick GD, Sicouri S, Sato A, Nagata Y, Iesaka Y, Aizawa Y, Kimura A, Hiraoka M, Anzelevitch C. A novel mutation in KCNQ1 associated with a potent dominant negative effect as the basis for the LQT1 form of the long QT syndrome J Cardiovasc Electrophysiol. 2007; 18 (9): 972-977.

Arimura T, Hayashi T, Kimura A. Molecular etiology of idiopathic cardiomyopathy Acta Myologica. 2007; 26 (3): 153-158.

Kimura A, Takahashi M, Choi BY, Bae SW, Hohta S, Sasaoka T, Nakahara K, Chida K, Sawabe M, Naruse T, Izumi T, Park JE. Lack of association between LTA and LGALS2 polymorphisms and myocardial infarction in Japanese and Korean populations Tissue Antigens. 2007; 69 (3): 265-269.

Sugimori C, Yamazaki H, Feng X, Mochizuki K, Kondo Y, Takami A, Chuhjo T, Kimura A, Teramura M, Mizoguchi H, Omine M, Nakao S. Roles of DRB11501 and DRB11502 in the pathogenesis of aplastic anemia Exp Hematol. 2007; 35 (1): 13-20.

Ota M, Katsuyama Y, Hamano H, Umemura T, Kimura A, Yoshizawa K, Kiyosawa K, Fukushima H, Bahram S, Inoko H, Kawa S. Two critical genes (HLA-DRB1 andABCF1) in the HLA region are associated with the susceptibility to autoimmune pancreatitis Immunogenetics. 2007; 59 (1): 45-52.

Arimura T, Matsumoto Y, Okazaki O, Hayashi T, Takahashi M, Inagaki N, Hinohara K, Ashizawa N, Yano K, Kimura A. Structural analysis of obscurin gene in hypertrophic cardiomyopathy Biochem Biophys Res Commun. 2007; 362 (2): 281-287.

Nakajima T, Ohtani H, Naruse T, Shibata H, Mimaya J, Terunuma H, Kimura A. Copy number variations of CCL3L1 and long-term prognosis of HIV-1 infection in asymptomatic HIV-infected Japanese with hemophilia Immunogenetics. 2007; 59 (10): 793-798.

Okaji Yurai, Tsuno Nelson Hirokazu, Kitayama Joji, Sakurai Daisuke, Tsuchiya Naoyuki, Saito Shinsuke, Takegami Kenji, Tsuchiya Takeshi, Kawai Kazushige, Yazawa Kentaro, Asakage Masahiro, Yoneyama Satomi, Yamada Jun, Tokunaga Katsushi, Takahashi Koki, Nagawa Hirokazu. Effects of down-regulating the Id genes in human colorectal cancer cells on early steps of haematogenous metastasis. Eur J Cancer. 2006.03; 42 (5): 668-673. ( PubMed, DOI )

Takahashi M, Yasunami M, Kubota S, Tamai H, Kimura A. HLA-DPB10202 is associated with a predictor of good prognosis of Graves disease in Japanese Hum Immunol. 2006; 67 (1-2): 47-52.

Inagaki N, Hayashi T, Arimura T, Koga Y, Takahashi M, Shibata H, Teraoka K, Chikamori T, Yamashina A, Kimura A. ?B-crystallin mutation in dilated cardiomyopathy Biochem Biophys Res Commun. 2006; 342 (2): 379-386.

Shibata H, Yasunami M, Obuchi N, Takahashi M, Kobayashi Y, Numano F, Kimura A. Direct determination of SNP haplotype of NFKBIL1 promoter polymorphism by DNA conformation analysis and its application to association study of chronic inflammatory diseases Hum Immunol. 2006; 67 (4-5): 363-373.

Tsuchiya Takeshi, Okaji Yurai, Tsuno Nelson H, Sakurai Daisuke, Tsuchiya Naoyuki, Kawai Kazushige, Yazawa Kentaro, Asakage Masahiro, Yamada Jun, Yoneyama Satomi, Kitayama Joji, Osada Takuya, Watanabe Toshiaki, Tokunaga Katsushi, Takahashi Koki, Nagawa Hirokazu. Targeting Id1 and Id3 inhibits peritoneal metastasis of gastric cancer. Cancer Sci. 2005.11; 96 (11): 784-790. ( PubMed, DOI )

Nakamura Naoya, Hase Hidenori, Sakurai Daisuke, Yoshida Sachiko, Abe Masafumi, Tsukada Nobuhiro, Takizawa Jun, Aoki Sadao, Kojima Masaru, Nakamura Shigeo, Kobata Tetsuji. Expression of BAFF-R (BR 3) in normal and neoplastic lymphoid tissues characterized with a newly developed monoclonal antibody. Virchows Arch. 2005.07; 447 (1): 53-60. ( PubMed, DOI )

Matsumoto Y, Hayashi T, Inagaki N, Takahashi M, Hiroi S, Nakamura T, ArimuraT, Nakamura K, Ashizawa N, Yasunami M, Ohe T, Yano K, Kimura A. Functional analysis of titin/connectin N2-B mutations found in cardiomyopathy J Muscle Res Cell Motil. 2005; 26 (6-8): 367-374.

Nishizaki M, Fujii H, Sakurada H, Kimura A, Hiraoka M. Spontaneous T wave alterans in a patient with Brugada syndrome - responses to intravenous administration of class I antiarrhythmic drug, glucose tolerance test, and atrial pacing J Cardiovasc Electrophysiol. 2005; 16 217-220.

Tanabe N, Kimura A, Amano S, Okada O, Kasahara Y, Tatsumi K, Takahashi M, Shibata H, Yasunami M, Kuriyama T. Association of clinical features with HLA in chronic pulmonary thromboembolism in Japan Eur Resp J. 2005; 25 (1): 131-138.

Munkanta M, Terunuma H, Takahashi M, Hanabusa H, Miura T, Ikeda S, Sakai M, Fujii T, Takahashi Y, Oka S, Matsuda J, Ishikawa M, Takashima Y, Mimaya J, Ito M, Kimura A, Yasumani M. HLA-B polymorphism in Japanese HIV-1 infected long-term surviving hemophiliacs Viral Immunol. 2005; 18 (3): 500-505.

Kubo T, Kitaoka H, Okawa M, Matsumura Y, Hitomi N, Yamazaki N, Furuno T, Takata J, Nishinaga M, Kimura A, Doi YL. Lifelong left ventricular remodeling of hypertrophic cardiomyopathy caused by a founder frameshift deletion mutation in the cardiac myosin-binding protein C gene J Am Coll Cardiol. 2005; 46 (9): 1737-1743.

Mori K, Sugimoto C, Ohgimoto S, Nakayama EE, Shinoda T, Kusagasa S, Takebe Y, Kano M, Matano T, Yuasa T, Kitagawa D, Miyazawa M, Takahashi Y, Yasunami M, Kimura A, Yamamoto N, Suzuki Y, Nagai Y. Influence of glycosylation on the efficacy of an Env-based vaccine against SIVmac239 in a macaque AIDS model J Virol. 2005; 79 (16): 10386-10389.

Noguchi Y, Yashima T, Hatanaka A, Uzawa M, Yasunami M, Kimura A, Kitamura K. A mutation in WFS1 in a Japanese family with autosomal dominant low-frequency sensorineural hearing loss Acta Oto-Laryngol. 2005; 125 (11): 1189-1194.

Shichi D, Kikkawa FE, Ota M, Katsuyama Y, Kimura A, Matsumori A, Kulsky JK, Naruse KT, Inoko H. The haplotype block, NFKBIL1-ATP6V1G2-BAT1-MICB-MICA, within the class III-class I boundary region of the human major histocompatibility complex may control susceptibility to hepatitis C virus associated dilated cardiomyopathy Tissue Antigens. 2005; 66 (3): 200-208.

Aizawa Y, Ueda K, Komura S, Washizuka T, Chinushi M, Inagaki N, Matsumoto Y, Hayashi T, Takahashi M, Nakano N, Yasunami M, Kimura A, Hiraoka M, Aizawa Y. A novel mutation in FKBP12-6 binding region of the human cardiac ryanodine receptor gene (R2401H) in Japanese patient with catecholaminergic polymorphic ventricular tachycardia Int J Cardiol. 2005; 99 (2): 343-345.

Sakurai Daisuke, Tsuchiya Naoyuki, Yamaguchi Akihiro, Okaji Yurai, Tsuno Nelson H, Kobata Tetsuji, Takahashi Koki, Tokunaga Katsushi. Crucial role of inhibitor of DNA binding/differentiation in the vascular endothelial growth factor-induced activation and angiogenic processes of human endothelial cells. J Immunol. 2004.11; 173 (9): 5801-5809. ( PubMed )

Hase Hidenori, Kanno Yumiko, Kojima Masaru, Hasegawa Kaoru, Sakurai Daisuke, Kojima Hidefumi, Tsuchiya Naoyuki, Tokunaga Katsushi, Masawa Nobuhide, Azuma Miyuki, Okumura Ko, Kobata Tetsuji. BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex. Blood. 2004.03; 103 (6): 2257-2265. ( PubMed, DOI )

Ogimoto A, Hamada M, Nakura J, Shigematsu Y, Hara Y, Ohtsuka T, Morishima A, Kimura A, Miki T, Hiwada K. 17-year follow-up study of a patient with obstructive hypertrophic cardiomyopathy with a deletion mutation in the cardiac myosin binding protein C gene Circ J. 2004; 68 174-177.

Komamura K, Iwai N, Kokame K, Yasumura Y, Kim J, Yamagishi M, Morisaki T, Kimura A, Tomoike H, Kitakaze M, Miyatake K. The role of a common TNNT2 polymorphism in cardiac hypertrophy J Hum Genet. 2004; 49 129-133.

Aizawa Y, Ueda K, Wu LM, Inagaki N, Hayashi T, Takahashi M, Ohta M, Kawano S, Hirano Y, Yasunami M, Aizawa Y, Kimura A, Hiraoka M. Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking FEBS Lett. 2004; 574 (1-3): 145-150.

Hamaguchi K, Kimura A, Kusuda Y, Yamashita T, Yasunami M, Takahashi M, Abe N, Yoshimatsu H. Clinical and genetic characteristics of GAD-antibody positive patients initially diagnosed as having type 2 diabetes Diabet Res Clin Pract. 2004; 66 (2): 163-171.

Matano T, Kobayashi M, Igarashi H, Takeda A, Nakamura H, Kano M, Sugimoto C, Mori K, Iida A, Hirata T, Hasegawa M, Yuasa T, Miyazawa M, Takahashi Y, Yasunami M, Kimura A, O'Connor DH, Watkins DI, Nagai Y. Cytotoxic T lymphocyte-based control of simian immunodeficiency virus replication in a preclinical AIDS vaccine trial J Exp Med. 2004; 199 (12): 1709-1718.

Ueda K, Nakamura K, Hayashi T, Inagaki N, Takahashi M, Arimura T, Morita H, Higashiuesata Y, Hirano Y, Yasunami M, Takishita S, Yamashina A, Ohe T, Sunamori M, Hiraoka M, Kimura A. Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia J Biol Chem. 2004; 279 (26): 27194-27198.

Hayashi T, Arimura T, Itoh-Satoh M, Ueda K, Hohda S, Inagaki N, Takahashi M, Hori H, Yasunami M, Nishi H, Koga Y, Nakamura H, Matsuzaki M, Cho BY, Bae SW, You CW, Han KH, Park JE, Kn?ll R, Hoshijima M, Chien KR, Kimura A. TCAP mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy J Am Coll Cardiol. 2004; 44 (11): 2192-2201.

Hayashi T, Arimura T, Ueda K, Shibata H, Hohda S, Takahashi M, Hori H, Koga Y, Oka N, Imaizumi T, Yasunami M, Kimura A. Identification and functional analysis of a caveolon-3 mutation associated with familial hypertrophic cardiomyopathy Biochem Biophys Res Commun. 2004; 313 (1): 178-184.

Yamashita T, Hamaguchi K, Kusuda Y, Kimura A, Sakata T, Yoshimatsu H. IKBL promoter polymorphism is strongly associated with resistance to type 1 diabetes in Japanese Tissue Antigens. 2004; 63 223-230.

Arimura T, Hayashi T, Terada H, Lee SY, Zhou Q, Takahashi M, Ueda K, Nouchi T, Hohda S, Sibutani M, Hirose M, Chen J, Park JE, Yasunami M, Hayashi H, Kimura A. A Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C J Biol Chem. 2004; 279 (8): 6746-6752.

Sasano T, Ueda K, Orikabe M, Hirano Y, Kawano S, Yasunami M, Isobe M, Kimura A, Hiraoka M. Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2: additional amino acids generated by frameshift cause accelerated inactivation J Mol Cell Cardiol. 2004; 37 (6): 1205-1211.

Sasaki K, Makita N, Sunami A, Sakurada H, Shirai N, Yokoi H, Kimura A, Tohse N, Hiraoka M, Kitabatake A. Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access Mol Pharmacol. 2004; 66 330-336.

Okamoto K, Makino S, Yoshikawa Y, Takaki A, Nagatsuka Y, Ota M, Tamiya G, Kimura A, Bahram S, Inoko H. Identification of IkBL as the second MHC-linked susceptibility locus for rheumatoid arthritis Am J Hum Genet. 2003; 72 303-312.

Shao W, Yasunami M, Takahashi M, Shibata H, Hamaguchi K, Sakata T, Ota M, Katsuyama Y, Inoko H, Kimura A. Analysis of HLA-B polymorphism in insulin dependent diabetes mellitus in Japanese MHC. 2003; 9 163-169.

Hohda S, Kimura A, Sasaoka T, Hayashi T, Ueda K, Yasunami M, Okabe M, Fukuda N, Kurosawa T, Izumi T. Association study of the CD14 polymorphism with myocardial infarction in Japanese populations Jpn Heart J. 2003; 44 (5): 613-622.

Yoshida M, Takano Y, Sasaoka T, Izumi T, Kimura A. E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under physiological flow conditions Arter Thrombo Vasc Biol. 2003; 23 783-788.

Kuroda N, Ohnishi Y, Kimura A, Yokoyama M. Clinical significance of T-wave alternans in hypertrophic cardiomyopathy Circ J. 2002; 66 457-462.

Knoell R, Hoshijima M, Hoffmann HM, Person V, Lorenzen-Schmidt I, Bang M-L, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork J, Jeffrey H, Omens J, Andrew D, McCulloch A, Kimura A, Gregorio CC, Poller W, Schaper J, Schulthelss HP, Chien KR. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy Cell. 2002; 111 943-955.

Hori H, Hattori S, Inouye S, Kimura A, Irie S, Miyazawa H, Sakaguchi M. Analysis of the major epitope of the alpha 2 chain of bovine type I collagen in children with bovine gelatin allergy J Allergy Clin Immunol. 2002; 110 652-658.

Harada H, Kimura A, Fukino K, Yasunaga S, Nishi H, Emi M. Genomic structure and eight novel exonic polymorphisms of the human N-cadherin gene J Hum Genet. 2002; 47 330-332.

Matsumori A, Furukawa Y, Hasegawa K, Sato Y, Nakagawa H, Morikawa Y, Miura K, Ohno Y, Inaba Y, Sasayama S, Fujiwara H, Hiroe M, Hori M, Imaizumi T, Inoko H, Izumi T, Kawai S, Kawana M, Kimura A, Kitabatake A, Kitamura S, Kitaura Y, Matsuzaki M, Nagai R, Ogawa S, Shimada T, Simotohno K, Takeda N, Takihara K, Tanaka M, Tei T, Toyo-oka T, Yamaguchi I, Yokoyama M, Yutani C. Epidemiologic and clinical characteristics of cardiomyopathies in Japan - Analysis by nationwide surveys Circ J. 2002; 66 323-336.

Itoh-Satoh M, Hayashi T, Nishi H, Koga Y, Arimura T, Ueda K, Hohta S, Nouchi T, Takahashi M, Hiroe M, Marumo F, Imaizumi T, Yasunami M, Kimura A. Titin mutations as the molecular basis for dilated cardiomyopathy Biochem Biophys Res Commun. 2002; 291 (2): 385-393.

Shirai N, Makita N, Sasaki K, Yokoi H, Sakuma I, Sakurada H, Akai J, Kimura A, Hiraoka M, Kitabatake A. A mutant cardiac sodium channel with multiple biophysical defects associated with overlapping clinical features of Brugada syndrome and cardiac conduction disease Cardiovasc Res. 2002; 53 348-354.

Sakaguchi M, Nakayama T, Kaku H, Taniguchi K, Saito S, Kimura A, Inoue S. Analysis of HLA in children with gelatin allergy Tissue Antigens. 2002; 59 412-416.

Sakurai D, Yamaguchi A, Tsuchiya N, Yamamoto K, Tokunaga K. Expression of ID family genes in the synovia from patients with rheumatoid arthritis. Biochem Biophys Res Commun. 2001.06; 284 (2): 436-442. ( PubMed, DOI )

Wakui M, Yamaguchi A, Sakurai D, Ogasawara K, Yokochi T, Tsuchiya N, Ikeda Y, Tokunaga K. Genes highly expressed in the early phase of murine graft-versus-host reaction. Biochem Biophys Res Commun. 2001.03; 282 (1): 200-206. ( PubMed, DOI )

Ota M, Katsuyama Y, Kimura A, Tsuchiya K, Kondo M, Naruse T, Itoh K, Sasazuki T, Inoko H. A second susceptibility gene for developing rheumatoid arthritis in the human MHC is located within a 70 kb interval telomeric of the TNF genes in the HLA class III region Genomics. 2001; 71 263-270.

Sasaoka T, Kimura A, Hohta S, Fukuda N, Kurosawa T, Izumi T. Polymorphisms in the platelet-endothelial cell adhesion molecule-1 (PECAM-1) gene, Asn563Ser and Gly670Arg, are associated with myocardial infarction in Japanese Ann NY Acad Sci. 2001; 947 259-269.

Soejima T, Kawamoto S, Akai J, Miyoshi O, Arai Y, Morohka T, Matsuo S, Niikawa N, Kimura A, Okubo K, Mukai T. Isolation of novel heart-specific genes using the bodymap Genomics. 2001; 74 115-120.

Arimura T, Suematsu N, Zhou YB, Nishimura J, Satoh S, Takeshita A, Kanaide H, Kimura A. Identification, characterization and functional analysis of heart-specific myosin light chain phosphatase small subunit J Biol Chem. 2001; 276 6073-6082.

Fukuda Y, Hoshino S, Shintaku S, Tanaka I, Dohi K, Kimura A. HLA-DMB polymorphism in living-related kidney transplantation Transpl Proc. 2001; 33 3302-3308.

Lee WH, Hwang TH, Kimura A, Park SW, Satoh M, Nishi H, Harada H, Toyama J, Park JE. Different expressivity of a ventricular essential light chain gene Ala57Gly mutation in familial hypertrophic cardiomyopathy Am Heart J. 2001; 141 184-189.

Kimura A, Itoh-Satoh M, Hayashi T, Takahashi M, Arimura T. Molecular etiology of idiopathic cardiomyopathy in Asian populations J Cardiol. 2001; 37 (Suppl): 139-146.

Obuchi N, Takahashi M, Nouchi T, Satoh M, Arimura T, Ueda K, Akai J, Ota M, Naruse T, Inoko H, Numano F, Kimura A. Identification of MICA alleles with a long Leu-repeat in the transmembrane region and no cytoplasmic tail due to a frameshift deletion in exon 4 Tissue Antigens. 2001; 57 520-535.

Ubalee R, Suzuki F, Kikuchi M, Tasanor O, Wattanagoon Y, Ruangweerayut II R, Na-Bangchang K, Karbwang J, Kimura A, Ito K, Kanda T, Hirayama K. Strong association of a tumor necrosis factor-alpha promoter allele with cerebral malaria in Myanmar Tissue Antigens. 2001; 58 407-410.

Tsuchiya K, Kimura A, Kondo M, Nishimura Y, Sasazuki T. Combination of HLA-A and HLA class II alleles controls the susceptibility to rheumatoid arthritis Tissue Antigens. 2001; 58 395-401.

Matsuzoe D, Hideshima T, Iwasaki A, Yoneda S, Kawahara K, Shirakusa T, Kimura A. Glutathione S-transferase nu1 null genotype is associated with K-ras gene mutation in lung adenocarcinoma among smokers Carcinogenesis. 2001; 22 1327-1330.

Takahashi M, Hashimoto H, Akizuki M, Sasazuki T, Nishikimi N, Ouchi H, Kobayashi Y, Numano F, Kimura A. Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese Tissue Antigens. 2001; 57 66-69.

Kikuchi M, Looareesuwan S, Ubalee R, Tasanor O, Suzuki F, Wattanagoon Y, Na-Bangchang K, Kimura A, Aikawa M, Hirayama K. Association of adhesion molecule PECAM-1/CD31 polymorphism with susceptibility to cerebral malaria in Thais Parasitol Int. 2001; 50 235-239.

Furuse M, Kimura A, Esaki M, Jo Y, Matsumoto T, Fujishima M. Polymorphism of the heat-shock protein gene HSP70-2 in ulcerative colitis MHC. 2000; 7 2-6.

Hamaguchi K, Kimura A, Seki N, Higuchi T, Yasunaga S, Takahashi M, Sasazuki T, Kusuda Y, Okeda T, Itoh K, Sakata T. Analysis of tumor necrosis factor-alpha promoter polymorphism in type 1 diabetes: HLA-B and -DRB1 alleles are primarily associated with the disease in Japanese Tissue Antigens. 2000; 55 10-15.

Kamizono S, Yamada K, Seki N, Higuchi T, Kimura A, Nonaka K, Itoh K. Susceptible locus for obese type 2 diabetes mellitus in the 5'-flanking region of the tumor necrosis factor-alpha gene Tissue Antigens. 2000; 55 449-452.

Kamizono S, Hiromatsu Y, Seki N, Bednarczuk T, Matsumoto H, Kimura A, Itoh K. A polymorphism of the 5' flanking region of tumor necrosis factor alpha gene is associated with thyroid-associated ophthalmopathy in Japanese Clin Endocrinol. 2000; 52 759-764.

Aida K, Juarez S, Kikuchi M, Gil M, Ayau O, DeLopez MP, Kaneko S, Yanagi T, Obispo T, Velasquez E, Jianbing M, Matta V, Paz M, Kimura A, Itoh K, Tada I, Hirayama K. HLA-B35 and MICA-A5 synergistically enhanced the susceptibility to Chagas disease, Trypanozoma cruzi infection MHC. 2000; 7 63-70.

Akai J, Makita N, Sakurada H, Shirai N, Ueda K, Kitabatake A, Nakazawa K, Kimura A, Hiraoka M. A novel SCN5A mutation associated with idiopathic ventricular fibrillation without typical ECG findings of Brugada syndrome FEBS Lett. 2000; 479 29-34.

Arimura T, Nakamura T, Hiroi S, Satoh M, Takahashi M, Ohbuchi N, Ueda K, Nouchi T, Yamaguchi N, Akai J, Matsumori A, Sasayama S, Kimura A. Characterization of human nebulette gene: A polymorphism in an actin-binding motif is associated with non-familial idiopathic dilated cardiomyopathy Hum Genet. 2000; 107 440-451.

Hata R, Akai J, Kimura A, Ishikawa O, Kuwana M, Sinkai H. Association of functional microsatellites in the human type 1 collagen alpha2 chain (COL1A2) gene with systemic screlosis Biochem Biophys Res Commun. 2000; 272 36-40.

Akai J, Kimura A, Hata R. Analysis of the topological properties of the two dinucleotide repeat regions that enhance the transcriptional activity of the human type 1 collagen alpha2 chain (COL1A2) gene promoter Connective Tissue. 2000; 32 259-265.

Kimura A, Ota M, Katsuyama Y, Ohbuchi N, Takahashi M, Kobayashi Y, Inoko H, Numano F. Mapping of the HLA-linked genes controlling the susceptibility to Takayasu's arteritis Int J Cardiol. 2000; 75 105-110.

Matsuzoe D, Hideshima T, Ohshima K, Kawahara K, Shirakusa T, Kimura A. Discrimination of double primary lung cancer from intrapulmonary metastasis by p53 gene mutation Br J Cancer. 1999; 79 1549-1552.

Seki N, Kamizono S, Yamada A, Matsumoto H, Niiya F, Kimura A, Tsuchiya K, Suzuki R, Date Y, Tomita T, Itoh K, Ochi T. Polymorphisms in the 5'-flanking region of tumor necrosis factor-alpha gene in patients with rheumatoid arthritis Tissue Antigens. 1999; 54 194-197.

Fukuma K, Marubayashi S, Okda K, Yamada K, Kimura A, Dohi K. Effect of lazaroid U-74389G and methylpredonisolone on endotoxin-induced shock in mice Surgery. 1999; 125 421-430.

Wang LM, Kimura A, Satoh M, Mineshita S. HLA linked with leprosy in southern China: HLA-linked resistance alleles to leprosy Int J Lepr. 1999; 67 403-408.

Matsuzoe D, Hideshima T, Kimura A, Inada K, Watanabe K, Akita Y, Kawahara K, Shirakusa T. p53 mutations predict non-small cell lung carcinoma response to radiotherapy Cancer Lett. 1999; 135 189-194.

Takahashi M, Kobayashi Y, Ichiki M, Ouchi H, Numano F, Kimura A. HLA-linked susceptibility and resistance to Buerger's disease in Japanese MHC. 1999; 5 7-12.

Satoh M, Takahashi M, Sakamoto T, Hiroe M, Marumo F, Kimura A. Structural analysis of the titin gene in hypertrophic cardiomyopathy - Identification of a novel disease gene Biochem Biophys Res Commun. 1999; 262 411-417.

Yoshitake S, Okada M, Kimura A, Sasazuki T. Contribution of major histocompatibility complex genes to susceptibility and resistance in Helicobactor Pyroli related diseases Eur J Gastroenterol Hepatol. 1999; 11 875-880.

Hiroi S, Harada H, Nishi H, Satoh M, Nagai R, Kimura A. Polymorphisms in the SOD2 and HLA-DRB1 genes are associated with non-familial idiopathic dilated cardiomyopathy in Japanese Biochem Biophys Res Commun. 1999; 261 332-339.

Doi YL, Kitaoka H, Hitomi N, Satoh M, Kimura A. Clinical expression in patients with hypertrophic cardiomyopathy caused by cardiac myosin-binding protein C gene mutation Circulation. 1999; 100 448-449.

Djoulah S, Busson M, Sasazuki T, Maillere B, Yasunaga S, Kimura A, Charron D, Hors J. A new predictive model for insulin-dependent diabetes mellitus susceptibility based on combinations of molecular HLA-DRB1 and HLA-DQB1 pockets Tissue Antigens. 1999; 54 341-148.

Akai J, Kimura A, Hata R. Transcriptional regulation of the human type I collagen alpha2 (COL1A2) gene by the combination of two dinucleotide repeats Gene. 1999; 239 65-73.

Yoshitake S, Kimura A, Okada M, Yao T, Sasazuki T. HLA class II alleles in Japanese patients with inflammatory bowel disease Tissue Antigens. 1999; 53 350-358.

Date Y, Seki N, Kamizono S, Higuchi T, Miyata K, Ohkuni M, Tatsuzawa O, Yokota S, Joo K, Ueda K, Joo K, Kimura A, Itoh K, Kato H. Identification of genetic risk factor for systemic rheumatoid arthritis in the 5'-flanking region of the TNF-alpha gene and HLA genes Arthr Rheumat. 1999; 42 2577-2582.

Shirai T, Hattori S, Sakaguchi M, Inoue S, Kimura A, Ebihara T, Irie S, Nagai R, Hori H. The complete cDNA coding sequence for the bovine proalpha2(I) chain of type I procollagen Matrix Biol. 1998; 17 85-88.

Hata R, Akai J, Kimura A. Cell position dependent reciprocal feedback regulation of type I collagen gene expression in cultured human skin fibroblasts Cell Biol Internat. 1998; 22 85-191.

Nomura Y, Kitteringham N, Shia K, Goseki M, Kimura A, Mineshita S. Use of the highly sensitive PCR method to detect the herpes Simplex Virus type 1 genome from Behchet disease patients J Med Dent Sci. 1998; 45 51-58.

Zeki K, Tanaka Y, Morimoto I, Nishimura Y, Kimura A, Yamashita U, Eto S. Induction of expression of MHC-class-II antigen on human thyroid carcinoma by wild-type p53 Int J Cancer. 1998; 75 391-395.

Kimura A, Kobayashi Y, Takahashi M, Ohbuchi N, Kitamura H, Satoh M, Nakamura T, Sasaoka T, Hiroi S, Aerbajinai W, Yasukochi Y, Numano F. MICA gene polymorphism in Takayasu arteritis and Buerger disease Int J Cardiol. 1998; 66S 107-113.

Matsumori A, Ohashi N, Sasayama S, Eto T, Fujisawa H, Imaizumi T, Izumi T, Kawamura K, Kawana M, Kimura A, Kitabatake A, Matsuzaki M, Nagai R, Tanaka H, Hiroe M, Hori M, Inoko H, Seko Y, Sekiguchi M, Shimotohno T, Sugishita Y, Takeda N, Takihara K, Tanaka M, Tokuhisa T, Toyooka T, Yokoyama M. Hepatitis C virus infection and cardiomyopathies: A multicenter study in Japan Jpn Circ J. 1998; 62 389-391.

Akai J, Kimura A, Arai K, Uehara K, Hata R. Fine structural analysis of the unique 5' region of human COL1A2 gene containing two regions of di-nucleotide repeats adjacent to the transcriptional start site Connective Tissue. 1998; 30 1-6.

Kai H, Muraishi A, Sugiu Y, Nishi H, Seki Y, Kuwahara F, Kimura A, Kato H, Imaizumi T. Expression of proto-oncogenes and gene mutation of sarcomeric proteins in patients with hypertrophic cardiomyopathy Circ Res. 1998; 83 594-601.

Higuchi T, Seki N, Kamizono S, Yamada A, Kimura A, Kato H, Itoh K. Polymorphism of the 5'-flanking region of human tumor necrosis factor (TNF)-alpha gene in Japanese Tissue Antigens. 1998; 51 605-612.

Kitamura H, Kobayashi Y, Kimura A, Numano F. Association of clinical manifestations with HLA-B alleles in Takayasu arteritis Int J Cardiol. 1998; 66S 121-126.

Ikeda M, Orimo H, Moriyama H, Yoshitaka T, Matsubara N, Mibu R, Tanaka N, Shimada T, Kimura A, Shimizu K. Close correlation between mutations of E2F4 and hMSH3 genes in colorectal cancers with microsatellite instability Cancer Res. 1998; 58 594-598.

Sasazuki T, Juji T, Morishima Y, Kinukawa N, Kashiwabara H, Inoko H, Yoshida T, Kimura A, Akaza T, Kamikawaji N, Kodera Y, Takaku F. Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor N Engl J Med. 1998; 339 1177-1185.

Hwang T, Lee W, Kimura A, Satoh M, Nakamura T, Kim M, Choi S, Park J. Early expression of a malignant phenotype of familial hypertrophic cardiomyopathy associated with a Gly716Arg myosin heavy chain mutation in a Korean family Am J Cardiol. 1998; 82 1509-1513.

Macaubas C, Jin L, Hallmeyer J, Kimura A, Mignot E. The complex mutation pattern of a microsatellite Genome Research. 1997; 7 635-641.

Miyata Y, Ohdan H, Noriyuki T, Shintaku S, Shibata S, Yamamoto H, Yoshioka S, Asahara T, Fukuda Y, Kimura A, Dohi K. Analysis of xenogeneic microchimerism in hamster-to-rat lung xenotransplantation Transplant Proc. 1997; 29 3505-3507.

Tashiro H, Fukuda Y, Kimura A, Hoshino S, Shintaku S, Ohdan H, Miyata H, Dohi K. Induction of donor-specific hyporeactivity in augmented microchimerism in rat liver transplantation followed by donor bone marrow Transplant Proc. 1997; 29 1196-1197.

Mignot E, Kimura A, Latterman A, Lin X, Yasunaga S, Rattazzi C, Jin L, Guilleminault C, Grumet FC, Dement WC, Underhill P. Extensive HLA class II studies in 58 non DRB115 (DR2) narcoleptic patients with cataplexy maps susceptibility to the coding region of DQA10102 and DQB10602 gene Tissue Antigens. 1997; 49 329-341.

Ohdan H, Fukuda Y, Shintaku S, Miyata Y, Tashiro H, Hoshino S, Sumimoto R, Asahara T, Kimura A, Dohi K. Prolongation of hamster-to-rat liver xenograft survival by donor bone marrow augmentation Transplant Proc. 1997; 29 925-927.

Ohsuzu F, Katsushika S, Akanuma M, Nakamura H, Harada H, Satoh M, Hiroi S, Kimura A. Hypertrophic obstructive cardiomyopathy due to a novel T-to-A transition at codon 624 in the beta-myosin heavy chain (beta-MHC) gene possibly related to the sudden death Int J Cardiol. 1997; 62 203-209.

Lin L, Jin L, Kimura A, Carrington M, Mignot E. DQ microsatellite association studies in three ethnic groups Tissue Antigens. 1997; 50 507-520.

Tashiro H, Fukuda Y, Kimura A, Hoshino S, Furukawa M, Shintaku S, Dohi K. Correlation of high-level microchimerism with graft acceptance in rat liver transplantation Transplant Proc. 1997; 29 1230-1231.

Munkhbat B, Sato T, Hagihara M, Tsuchida F, Sato K, Kimura A, Munkhtuvshin N, Tsuji K. Molecular analysis of HLA polymorphism in Khoton-Mongolians Tissue Antigens. 1997; 50 124-134.

Kimura A, Harada H, Park J, Nishi H, Satoh M, Takahashi M, Hiroi S, Sasaoka T, Ohbuchi N, Nakamura T, Koyanagi T, Hwang T, Choo J, Chung K, Hasegawa A, Nagai R, Okazaki O, Nakamura H, Matsuzaki M, Sakamoto T, Toshima H, Koga Y, Imaizumi T, Sasazuki T. Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy Nature Genet. 1997; 16 379-382.

Kimura A. Molecular genetics of hypertrophic cardiomyopathy in Japan Internal Med. 1997; 36 152-154.

Mori K, Sasazuki T, Kimura A, Ito Y. HLA-DP antigens and poststrreptococcal acute glomerulonephritis in Japan Acta Paediatrica. 1996; 85 916-918.

Fukuda Y, Kimura A, Hoshino S, Shintaku S, Sakaguchi T, Asahara T, Sakaki M, Sumimoto R, Tashiro H, Furukawa M, Ohdan H, Yoshida T, Dohi K. HLA-DR8 subtyping by polymerase chain reaction (PCR)- DNA conformation polymorphism (DCP) analysis: a simple and practical genotyping method Hiroshima Med Sci. 1996; 45 85-92.

Date Y, Kimura A, Kato Y, Sasazuki T. DNA typing of HLA-A gene - population study and identification of four new alleles in Japanese Tissue Antigens. 1996; 47 93-101.

Yasunaga S, Kimura A, Hamaguchi K, Roenningen KS, Sasazuki T. Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM) Tissue Antigens. 1996; 47 37-48.

Aerbajinai W, Tsuchiya T, Kimura A, Yasukochi Y, Numano F. HLA class II DNA typing in Buerger's disease Int J Cardiol. 1996; 54S 197-202.

Koga Y, Toshima H, Kimura A, Harada H, Koyanagi T, Nishi H, Nakata M, Imaizumi T. Clinical manifestations of hypertrophic cardiomyopathy with mutations in the cardiac beta-myosin heavy chain and cardiac troponin T genes J Cardiac Failure. 1996; 2S 97-103.

Tashiro H, Fukuda Y, Kimura A, Hoshino S, Ito H, Dohi K. Assessment of microchimerism in rat liver transplantation by polymerase chain reaction Hepatology. 1996; 23 828-834.

Tamai H, Sudo T, Kimura A, Matsubayashi S, Kuma K, Nagataki S. Association between the DRB108032 histocompatibility antigen and methimazole-induced agranulocytosis in Japanese patients with Graves disease Ann Internal Med. 1996; 124 490-494.

Koyanagi T, Koga Y, Nishi H, Toshima H, Sasazuki T, Imaizumi T, Kimura A. DNA typing of HLA class II genes in Japanese patients with rheumatic heart disease J Mol Cell Cardiol. 1996; 28 1349-1353.

Hirayama K, Samah MZA, Sulaiman LH, Kimura A, Joo OK, Kikuchi M, Abdullah NH, Kojima S, Wah MJ. Molecular analysis of HLA-B in the Malaysian aborigines Tissue Antigens. 1996; 48 692-697.

Maruya E, Ishikawa Y, Lin L, Tokunaga K, Kimura A, Nita H, Yokoyama S, Saji H. Allele typing of HLA-A10 group by nested-PCR-low ionic strength single strand conformation polymorphism and a novel A26 allele (A26KY, A2605) Hum Immunol. 1996; 50 140-147.

Shintaku S, Fukuda Y, Kimura A, Hoshino S, Asahara T, Dohi K. HLA-A and -B genotyping in living related one haploidentical kidney transplantation Jpn J Med Sci Biol. 1996; 49 187-200.

Kimura A, Kitamura H, Date Y, Numano F. Comprehensive analysis of HLA genes in Takayasu arteritis in Japan Int J Cardiol. 1996; 54S 65-73.

Hori T, Kamikawaji N, Kimura A, Sone T, Komiyama N, Komiyama S, Sasazuki T. Japanese ceder pollinosis and HLA-DP5 Tissue Antigens. 1996; 47 485-491.

Muto M, Date Y, Ichimiya M, Mori K, Kamikawaji N, Kimura A, Sasazuki T, Asagami C. Significance of antibodies to streptococcal M protein in psoriatic arthritis and their association with HLA-A0207 Tissue Antigens. 1996; 48 645-650.

Jin L, Macaubas C, Hallmayer J, Kimura A, Mignot E. Mutation rate varies among alleles at a microsatellite locus: phylogenic evidence Proc Natl Acad Sci USA. 1996; 93 15285-15288.

Mukai T, Kimura A, Ishibashi H, Sasazuki T, Sata M, Maruyama T, Sakai H, Niho Y. Association of HLA-DRB10803 and 1602 with the susceptibility to primary biliary cirrhosis Intrenat Hepatol Commun. 1995; 3 207-212.

Dong RP, Kamikawaji N, Toida N, Fujita Y, Kimura A, Sasazuki T. Characterization of T cell epitopes in streptococcal M12 protein restricted by HLA-DP9 J Immunol. 1995; 154 4536-4545.

Haas JP, Kimura A, Truckenbrodt H, Suschke J, Sasazuki T, Volgger A, Albert ED. Early-onset pauciarticular juvenile chronic arthritis is associated with a mutation in the Y-box of the HLA-DQA1 promoter Tissue Antigens. 1995; 45 317-321.

Petronzelli F, Kimura A, Ferrante P, Mazzilli MC. Polymorphism in the upstream regulatory region of DQA1 gene in the Italian population Tissue Antigens. 1995; 45 258-263.

Mignot E, Kimura A, Abbal M, Thorsby E, Lin X, Voros A, Macaubas C, Bouissou F, Sollid LM, Cambon-Thomsen A, Yasunaga S, Grumet FC. DQCAR microsatellite polymorphisms in three selected HLA Class II associated diseases Tissue Antigens. 1995; 46 299-304.

Sudo T, Kamikawaji N, Kimura A, Date Y, Savoie CJ, Nakashima H, Furuichi E, Kuhara S, Sasazuki T. Differences in MHC-class I self peptide repertoires among HLA-A2 subtypes J Immunol. 1995; 155 4749-4756.

Nishi H, Kimura A, Harada H, Koga Y, Adachi K, Matsuyama K, Koyanagi T, Imaizumi T, Toshima H, Sasazuki T. A myosin missense mutation, not a null allele, causes familial hypertrophic cardiomyopathy Circulation. 1995; 91 2911-2915.

Nakajima A, Matsuhashi N, Kodama T, Yazaki Y, Takazoe M, Kimura A. HLA-linked disease susceptibility gene and disease resistance gene in Crohn's disease Gastroenterol. 1995; 109 1462-1467.

Tashiro H, Fukuda Y, Kimura A, Hoshino S, Furukawa M, Shintaku S, Dohi K. Monitoring for engraftment of rat orthotopic liver transplantation by semiquantitative PCR Transpl Proc. 1995; 27 537-539.

Fukuda Y, Kimura A, Hoshino S, Tashiro H, Furukawa M, Shintaku S, Hori H, Sasazuki T, Dohi K. Significance of the HLA-DQB1 matching in one-haplotype identical kidney transplant pairs and the matching analysis by the polymerase chain reaction (PCR)-heteroduplex-polymorphism method Tissue Antigens. 1995; 45 49-56.

Nishi H, Koga Y, Koyanagi T, Harada H, Imaizumi T, Toshima H, Sasazuki T, Kimura A. DNA typing of HLA class II genes in Japanese patients with dilated cardiomyopathy J Mol Cell Cardiol. 1995; 27 2385-2392.

Wan XL, Kimura A, Dong RP, Honda K, Tamai H, Sasazuki T. HLA-A and DRB4 genes in controlling the susceptibility to Hashimoto's thyroiditis Hum Immunol. 1995; 42 131-136.

Shintaku S, Kimura A, Fukuda Y, Date Y, Tashiro H, Hoshino S, Furukawa M, Sasazuki T, Dohi K. Polymerase chain reaction-based HLA-A genotyping and its application to matching in kidney transplantation Transpl Proc. 1995; 27 689-692.

Macaubas C, Hallmayer J, Kalil J, Kimura A, Yasunaga S, Grumet FC, Mignot E. Extensive polymorphism of a (CA)n microsatellite located in the HLA-DQA1/DQB1 class II region Hum Immunol. 1995; 42 209-220.

Ohsako N, Tamai H, Sudo T, Mukuta T, Tanaka H, Kuma K, Kimura A, Sasazuki T. Clinical characteristics of subacute thyroiditis classified according to Human Leukocyte Antigen typing J Clin Endocrionol Metab. 1995; 80 3653-3656.

Nakao M, Yamana H, Imai Y, Toh Y, Toh U, Kimura A, Yanoma S, Kakegawa T, Itoh K. HLA A2601-restricted cytotoxic T lymphocytes recognizing a peptide antigen expressed on squamous cell carcinoma Cancer Res. 1995; 55 4248-4252.

Kato M, Takazawa K, Kimura A, R?egg JC, Amano K, Wang Y, Sasaki Y, Toyo-oka T. Altered actin binding with myosin mutation in hypertrophic cardiomyopathy and sudden death Lancet. 1995; 345 1247.

Tashiro H, Fukuda Y, Kimura A, Hoshino S, Sakaguchi T, Fukukawa M, Shintaku S, Dohi K. Monitoring for engraftment following rat orthotopic liver transplantation by polymerase chain reaction Transpl Proc. 1994; 26 902-903.

Otsuka S, Kimura A, Date Y, Koyanagi T, Kunstman E, Hirose M, Yamada Y, Noma A. Fatal transfusion-associated graft-versus-host disease Transfusion. 1994; 34 936-937.

Haas JP, Kimura A, Andreas A, Hochberger M, Keller E, Brennler G, Bettinotti MP, Yao Z, Nevinny-Stickel C, Sierp G, Sasazuki T, Albert ED. Polymorphism in the upstream regulatory regions of DQA1 genes and DRB1, QAP, DQA1, DQB1 haplotypes in the German population Hum Immunol. 1994; 39 31-40.

Konenkov V, Sartakova M, Kimura A. Oligonucleotide genotyping of HLA-DRB104 and HLA-DQB103 among Russians in west Siberia suffering from rheumatoid arthritis Exp Clin Immunogenet. 1994; 11 187-191.

Esaki Y, Fukui Y, Sudo T, Yamamoto K, Inamitsu T, Nishimura Y, Hirokawa K, Kimura A, Sasazuki T. Role of human major histocompatibility complex DQ molecules in superantigenicity of Streptococcus-derived protein Infect Immun. 1994; 62 1228-1235.

Fukuda Y, Tashiro H, Hoshino S, Kimura A, Dohi K. Identification of donor-derived cells in organ transplants by in vitro amplification of Y-chromosome gene using polymerase chain reaction Cell Transpl. 1994; 3S 27-28.

Undlien DE, Hamaguchi K, Kimura A, Tuomilehto-Wolf E, Swai ABM, McLarty DG, Tuomilehto J, Thorsby E, Roenningen KS. IDDM susceptibility associated with polymorphisms in the insulin gene region - A study of Blacks, Caucasians and Orientals Diabetologia. 1994; 37 745-749.

Nakano S, Tatsumoto T, Esaki T, Nakamura M, Baba E, Kimura A, Ohshima K, Niho Y. Characterization of a newly established human gallbladder carcinoma cell line In vitro Cell Dev Biol. 1994; 30A 729-732.

Shintaku S, Fukuda Y, Tashiro H, Hoshino S, Dohi K, Kimura A. Simple and rapid HLA-DRB typing method for transplantation using polymerase chain reaction-sequence-specific primers in combination with DNA conformation polymorphism analysis Transpl Proc. 1994; 26 1893-1896.

Fukuda Y, Hoshino S, Kimura A, Dohi K, Sasazuki T. Negative effect of HLA-DQ antigen compatibility (concordance) on the survival of kidney grafts Transpl Proc. 1994; 26 1887-1890.

Hashimoto H, Nishimura Y, Dong RP, Kimura A, Sasazuki T, Yamanaka K, Takano Y, Murashima A, Kabasawa K, Hirose S. HLA antigens in Japanese patients with systemic lupus erythematosus Scand J Rheumatol. 1994; 23 191-196.

Tamai H, Kimura A, Dong RP, Matsubayashi S, Kuma K, Nagataki S, Sasazuki T. Resistance to autoimmune thyroid disease is associated with HLA-DQ J Clin Endocrionol Metab. 1994; 78 94-97.

Tashiro H, Fukuda Y, Kimura A, Hoshino S, Sakaguchi T, Fukukawa M, Shintaku S, Dohi K. Monitoring for rejection and engraftment by means of the polymerase chain reaction after rat orthotopic liver transplantation Transplantation. 1994; 58 745-748.

Shintaku S, Fukuda Y, Kimura A, Hoshino S, Tashiro H, Sasazuki T, Dohi K. DNA conformation polymorphism (DCP) analysis of DR52 associated HLA-DR antigens by polymerase chain reaction (PCR) - A simple, economical, and rapid examination for HLA matching in transplantation Jpn J Med Sci Biol. 1994; 46 165-181.

Ishikawa Y, Tokunaga K, Lin L, Imanishi T, Saitou S, Kimura A, Kashiwase K, Akaza T, Tadokoro K, Juji T. Sequences of four splits of HLA-A10 group: Implication for serologic cross-reactivities and their evolution Hum Immunol. 1994; 39 220-224.

Kimura A, Date Y, Sasazuki T. DNA typing of the HLA-A gene MHC & IRS. 1994; S1 13-22.

Nishi H, Kimura A, Harada H, Adachi K, Koga Y, Sasazuki T, Toshima H. Possible gene dose effect of a mutant cardiac beta-myosin heavy chain gene on the clinical expression of hypertrophic cardiomyopathy Biochem Biophys Res Commun. 1994; 200 549-556.

Yamamoto K, Fukui Y, Esaki Y, Inamitsu T, Sudo T, Yamane K, Kamikawaji N, Kimura A, Sasazuki T. Functional interaction between human histocompatibility leukocytes antigen (HLA) class II and mouse CD4 molecules in antigen recognition by T cells in HLA-DR and DQ transgenic mice J Exp Med. 1994; 180 165-171.

Hoshino S, Kimura A, Fukuda Y, Hori H, Sasazuki T, Dohi K. A practical HLA-DRB and -DQB matching test in kidney transplantation Transpl Proc. 1993; 25 191-193.

Honda K, Kimura A, Dong RP, Tamai H, Nagato H, Nishimura Y, Sasazuki T. Immunogenetic analysis of silicosis in Japan Am J Resp Cell Mol Biol. 1993; 8 106-111.

Dong RP, Kimura A, Hashimoto H, Akizuki M, Nishimura Y, Sasazuki T. Difference in HLA-linked genetic background between mixed connective tissue disease and systemic lupus erythematosus Tissue Antigens. 1993; 41 20-25.

Kimura A, Fukuda Y, Hori H, Hoshino S, Sasazuki T, Dohi K. PCR-SSCP analysis of HLA-DP genes and its application to matching study in transplantation Transpl Proc. 1993; 25 199-202.

Kato A, Hirosawa S, Toyota S, Nakamura Y, Nishi H, Kimura A, Sasazuki T, Aoki N. Localization of the human alpha2-plasmin inhibitor gene (PLI) to 17p13 Cyogenet Cell Genet. 1993; 62 190-191.

Fukui Y, Yamamoto K, Yokoyama N, Iwanaga T, Kurashima C, Esaki Y, Kimura A, Akashi T, Hirokawa K, Sasazuki T. Restricted expression of transgenic HLA-DRA gene in thymic epithelial cells and its role in aquisition of T cell tolerance to self-superantigens and processed DR?-derived peptide Eur J Immunol. 1993; 23 1678-1686.

Bettinotti PM, Kolek A, Brennler G, Haas P, Paul C, Hochberger H, Bartova A, Kimura A, Sasazuki T, Albert ED. Polymorphism of the 5' flanking region of the HLA-DQA1 gene in Coeliac disease Eur J Immunogenet. 1993; 20 399-407.

Harada H, Kimura A, Nishi H, Sasazuki T, Toshima H. A missense mutation of cardiac beta-myosin heavy chain gene linked to familial hypertrophic cardiomyopathy in affected Japanese families Biochem Biophys Res Commun. 1993; 194 791-798.

Yao Z, Kimura A, Hartung K, Haas PJ, Volgger A, Brennler G, Benisch J, Albert ED. LE study group members: Polymorphism of the DQA1 promoter region (QAP) and DRB1, QAP, DQA1, DQB1 haplotypes in systemic lupus erythematosus Immunogenetics. 1993; 38 421-429.

Yoshida M, Kimura A, Katsuragi K, Numano F, Sasazuki T. DNA typing of HLA-B gene in Takayasu's arteritis Tissue Antigens. 1993; 42 87-90.

Fukui Y, Esaki Y, Kimura A, Hirokawa K, Nishimura Y, Sasazuki T. T cell repertoire in a strain of transgenic C57BL/6 mice with the HLA-DRA gene on the X chromosome Immunogenetics. 1993; 37 204-211.

Dong RP, Kimura A, Ohkubo R, Shinagawa H, Tamai H, Nishimura Y, Sasazuki T. HLA-A and DPB1 loci confer susceptibility to Graves' disease Hum Immunol. 1992; 35 165-172.

Nishi H, Kimura A, Fukuda S, Kusukawa R, Kawamura K, Nimura Y, Nagano M, Yasuda H, Kawai C, Sugimoto T, Okada R, Yazaki Y, Tanaka H, Harumi K, Koga Y, Sasazuki T, Toshima H. Genetic analysis of dilated cardiomyopathy: HLA and immunoglobulin genes may confer susceptibility Jpn Circ J. 1992; 56 1054-1061.

Nishi H, Kimura A, Harada H, Toshima H, Sasazuki T. Novel missense mutation in cardiac beta-myosin heavy chain gene found in a Japanese patient with hypertrophic cardiomyopathy Biochem Biophys Res Commun. 1992; 188 379-387.

Matsumori A, Tominaga M, Kawai C, Yasuda H, Kawaguchi H, Sano H, Kohya T, Nakayama H, Kuboki Y, Yasui S, Sugishita Y, Nagano M, Okada R, Handa S, Yoshikawa T, Harumi K, Nakamura H, Ohsuzu F, Hayakawa H, Munakata K, Nobuoka S, Murayama M, Sato T, Takeshi M, Horie T, Fujita T, Machii K, Hirai H, Yabe Y, Sugimoto T, Iizuka M, Nonomura Y, Yazaki Y, Toyooka T, Yamazaki N, Izumi T, Sekiguchi M, Watanabe T, Motomura H, Morimoto S, Mizuno Y, Ozawa Y, Kawamura K, Kitabatake A, Nagata S, Fujita T, Omae T, Nimura Y, Nishio I, Arita M, Yokota Y, Yokoyama M, Inoh T, Hayakawa M, Matsuo H, Nakajima S, Kusukawa R, Takeshita A, Urabe Y, Kimura A, Toshima H, Koga Y, Kuroiwa A, and Tanaka H. A questionnaire study of ?-adrenergic blokade in dilated cardiomyopathy in Japan Jpn Circ J. 1992; 56 767-775.

Dong RP, Kimura A, Sasazuki T. Sequence analysis of three novel DRw14-DRB1 alleles Immunogenetics. 1992; 36 130-133.

Hirashima M, Ono T, Nakao M, Nishi H, Kimura A, Nomiyama H, Hamada F, Yoshida MC, Shimada K. Nucleotide sequence of the third cytokine LD78 gene and mapping of all three LD78 gene loci to human chromosome 17 DNA Sequence. 1992; 3 203-212.

Senju S, Kimura A, Yasunami M, Kamikawaji N, Yoshizumi H, Nishimura Y, Sasazuki T. Allele-specific expression of the cytoplasmic exon of HLA-DQB1 gene Immunogenetics. 1992; 36 (5): 319-325.

Kimura A, Dong RP, Harada H, Sasazuki T. DNA typing of HLA class II genes in B-lymphoblastoid cell lines homozygous for HLA Tissue Antigens. 1992; 40 5-12.

Dong RP, Kimura A, Numano F, Nishimura Y, Sasazuki T. HLA-linked susceptibility and resistance to Takayasu arteritis Heart and Vessels. 1992; 7S 73-80.

Nishi H, Kimura A, Harada H, Hayashi Y, Nakamura M, Sasazuki T. Novel variant transthyretin gene (Ser50 to Ile) in familial cardiac amyloidosis Biochem Biophys Res Commun. 1992; 187 460-466.

Yoshida M, Kimura A, Numano F, Sasazuki T. Polymerase chain reaction based analysis of polymorphism in the HLA-B gene Hum Immunol. 1992; 34 257-266.

Harada H, Kimura A, Dong RP, Xu XP, Bhatia K, Sasazuki T. Sequencing and population analysis of four novel HLA-DPA1 alleles Hum Immunol. 1992; 35 173-178.

Hatae K, Kimura A, Ohkubo R, Watanabe H, Erlich HA, Ueda K, Nishimura Y, Sasazuki T. Genetic control of non-responsiveness to hepatitis B virus vaccine by an extended HLA haplotype Eur J Immunol. 1992; 22 1899-1905.

Oedum N, Yoshizumi H, Okamoto Y, Kamikawaji N, Kimura A, Nishimura Y, Sasazuki T. Signal transduction by HLA class II molecules in human T cells: Induction of LFA-1-dependent and independent adhesion Hum Immunol. 1992; 35 71-84.

Dong RP, Kimura A, Numano F, Yajima M, Hashimoto Y, Kishi Y, Nishimura Y, Sasazuki T. HLA-DP antigen and Takayasu arteritis Tissue Antigens. 1992; 39 106-110.

Hoshino S, Kimura A, Fukuda Y, Dohi K, Sasazuki T. Polymerase chain reaction-single strand conformation polymorphism analysis of polymorphisms in DPA1 and DPB1 gene - A simple, economical and rapid method for histocompatibility testing Hum Immunol. 1992; 33 98-107.

Hansen T, Roenningen KS, Ploski R, Kimura A, Thorsby E. Coding region polymorphisms of human T cell receptor Vb6-9 and Vb21-4 Scand J Immunol. 1992; 36 285-290.

Fujisawa K, Kamikawaji N, Yasunami M, Kimura A, Nishimura Y, Sasazuki T. High precursor frequency of human T cells reactive to HLA-DQ molecules expressed on mouse L cell transfectants Eur J Immunol. 1991; 21 (10): 2341-2347.

Kamikawaji N, Fujisawa K, Yoshizumi H, Fukunaga M, Yasunami M, Kimura A, Nishimura Y, Sasazuki T. HLA-DQ restricted CD4+ T cells specific to streptococcal antigen exist in low responder but not in high responder J Immunol. 1991; 146 (8): 2560-2567.

Tamaki K, Yamamoto T, Uchihi R, Katsumata Y, Kondo K, Mizuno S, Kimura A, Sasazuki T. Frequency of HLA-DQA1 alleles in the Japanese population Hum Hered. 1991; 41 209-214.

Nishimura Y, Kamikawaji N, Fujisawa K, Yoshizumi H, Yasunami M, Kimura A, Sasazuki T. Genetic control of immune response and disease susceptibility by the HLA-DQ gene Res Immunol. 1991; 142 (5-6): 459-466.

Nishimura Y, Iwanaga T, Inamitsu T, Yanagawa Y, Yasunami M, Kimura A, Hirokawa K, Sasazuki T. Expression of human MHC, HLA-DQw6 genes alter the immune response in C57BL/6 mice J Immunol. 1990; 145 (1): 353-360.

Urabe K, Kimura A, Harada F, Iwanaga T, Sasazuki T. Gene conversion in 21-hydroxylase genes Am J Hum Genet. 1990; 46 1178-1186.

Sasazuki T, Iwanaga T, Inamitsu T, Yanagawa Y, Yasunami M, Kimura A, Hirokawa K, Nishimura Y. Expression and function of human major histocompatibility complex HLA-DQw6 genes in the C57BL/6 mouse Cold Spring Harbor Symp Quant Biol. 1989; 54 (Pt 1): 513-520.

Fukui Y, Nishimura Y, Iwanaga T, Kimura A, Inamitsu T, Hanaoka Y, Kitagawa T, Sasazuki T. Analysis of glucosuria and insulitis in NOD mice expressing HLA-DQw6 molecule J Immunogenet. 1989; 16 445-453.

Israel A, Kimura A, Kieran M, Yano O, Kanellopoulos J, Le Bail O, Kourilsky P. A common positive trans-acting factor binds to enhancer sequences in the promoters of mouse H-2 and beta-2-microglobulin genes Proc Natl Acad Sci USA. 1987; 84 2653-2657.

Tsukamoto K, Yasunami M, Kimura A, Inoko H, Ando A, Hirose T, Inayama S, Sasazuki T. DQw1beta gene from HLA-DR2-Dw12 consists of six exons and expresses multiple DQw1? polypeptides through alternative splicing Immunogenetics. 1987; 25 (2): 343-346.

Harada F, Kimura A, Iwanaga T, Shimozawa K, Yata J, Sasazuki T. Gene conversion-like events cause steroid 21-hydroxylase deficiency in congenital adrenal hyperplasia Proc Natl Acad Sci USA. 1987; 84 8091-8094.

Israel A, Kimura A, Fournier A, Fellous M, Kourilsky P. Interferon response sequence potentiates activity of an enhancer in the promoter region of a mouse H-2 gene Nature. 1986; 322 743-746.

Kimura A, Israel A, Le Bail O, Kourilsky P. Detailed analysis of the mouse H-2 Kb promoter: Enhancer-like sequences and their role in the regulation of class I gene expression Cell. 1986; 44 261-272.

Matsunaga E, Kimura A, Yamada H, Fukumaki Y, Takagi Y. A novel deletion in delta-beta-thalassemia found in Japan Biochem Biophys Res Commun. 1985; 126 185-191.

Kimura A, Takagi Y. A frameshift addition causes silencing of the delta-globin gene in an old world monkey, an anubis (Papio doguera) Nucl Acids Res. 1984; 11 2541-2550.

Kimura A, Ohta Y, Fukumaki Y, Takagi Y. A fusion gene in man: DNA sequence analysis of the abnormal globin gene of Hemoglobin Miyada Biochem Biophys Res Commun. 1984; 119 968-974.

Kimura A, Matsunaga E, Takihara Y, Nakamura T, Takagi Y, Lin S, Lee H. Structural analysis of a beta-thalassemia gene found in Taiwan J Biol Chem. 1983; 258 2748-2749.

Kimura A, Shimada K, Takagi Y. Re-examination of the ColE1 DNA regions essential for autonomous replication and their functions J Biochem. 1982; 92 95-103.

Ozaki LS, Kimura A, Shimada K, Takagi Y. ColEl vectors for direct selection of cells carrying a hybrid plasmid J Biochem. 1982; 91 1151-1162.

Kimura A, Matsunaga E, Ohta Y, Fujiyoshi T, Matsuo T, Nakamura T, Imamura T, Yanase T, Takagi Y. Structure of cloned delta-globin genes from a normal subject and a patient with delta-thalassemia - Sequence polymorphisms found in the delta-globin gene region of Japanese individuals Nucl Acids Res. 1982; 10 5725-5732.