Fumiaki Ando, Yu Hara, Shinichi Uchida. Identification of protein kinase A signalling molecules in renal collecting ducts. J Physiol. 2023.04; ( PubMed, DOI )

Junki Kurimoto, Hiroshi Takagi, Takashi Miyata, Yohei Kawaguchi, Yuichi Hodai, Tetsuro Tsumura, Daisuke Hagiwara, Tomoko Kobayashi, Yoshinori Yasuda, Mariko Sugiyama, Takeshi Onoue, Shintaro Iwama, Hidetaka Suga, Ryoichi Banno, Takeshi Katsuki, Fumiaki Ando, Shinichi Uchida, Hiroshi Arima. Mineralocorticoids induce polyuria by reducing apical aquaporin-2 expression of the kidney in partial vasopressin deficiency. Endocr J. 2023.03; 70 (3): 295-304. ( PubMed, DOI )

Nobuhisa Morimoto, Takayasu Mori, Shingo Shioji, Hatsumi Watanabe, Keigo Sakai, Katsuo Mori, Ayumi Yamamura, Asami Hanioka, Yuichiro Akagi, Tamami Fujiki, Shintaro Mandai, Yutaro Mori, Fumiaki Ando, Koichiro Susa, Soichiro Iimori, Shotaro Naito, Eisei Sohara, Shinichi Uchida. Thrombocytopenia during avacopan administration: A case report. Int J Rheum Dis. 2023.03; ( PubMed, DOI )

Takaaki Koide, Shintaro Mandai, Reo Kitaoka, Hisazumi Matsuki, Motoko Chiga, Kouhei Yamamoto, Kotaro Yoshioka, Yohsuke Yagi, Soichiro Suzuki, Tamami Fujiki, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Shotaro Naito, Eisei Sohara, Tatemitsu Rai, Takanori Yokota, Shinichi Uchida. Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease. Circ Res. 2023.02; 132 (4): 415-431. ( PubMed, DOI )

Shizuka Kirino, Analia Yogi, Eriko Adachi, Hisae Nakatani, Maki Gau, Ryosei Iemura, Haruki Yamano, Toru Kanamori, Takayasu Mori, Eisei Sohara, Shinichi Uchida, Kentaro Okamoto, Tomohiro Udagawa, Kei Takasawa, Tomohiro Morio, Kenichi Kashimada. Phenotypic Variation in 46,XX Disorders of Sex Development due to the 4th Zinc Finger Domain Variant of WT1 : A Familial Case Report. Sex Dev. 2023.02; ( PubMed, DOI )

Soichiro Suzuki, Fumiaki Ando, Sae Kitagawa, Yu Hara, Tamami Fujiki, Shintaro Mandai, Koichiro Susa, Takayasu Mori, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida. ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells. Commun Biol. 2023.01; 6 (1): 29. ( PubMed, DOI )

Tomoki Yanagi, Hiroaki Kikuchi, Koichiro Susa, Naohiro Takahashi, Hiroki Bamba, Takefumi Suzuki, Yuta Nakano, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Shintaro Mandai, Takayasu Mori, Koh Takeuchi, Shinya Honda, Satoru Torii, Shigeomi Shimizu, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara. Absence of ULK1 decreases AMPK activity in the kidney, leading to chronic kidney disease progression. Genes Cells. 2023.01; 28 (1): 5-14. ( PubMed, DOI )

Maho Hatano, Tomohiro Udagawa, Toru Kanamori, Akito Sutani, Takayasu Mori, Eisei Sohara, Shinichi Uchida, Tomohiro Morio, Masato Nishioka. A novel SLC5A2 heterozygous variant in a family with familial renal glucosuria. Hum Genome Var. 2022.12; 9 (1): 42. ( PubMed, DOI )

Nakano Y, Mandai S, Genma T, Akagi Y, Fujiki T, Ando F, Susa K, Mori T, Iimori S, Naito S, Sohara E, Uchida S, Fushimi K, Rai T. Nationwide mortality associated with perioperative acute dialysis requirement in major surgeries. International journal of surgery (London, England). 2022.08; 104 106816. ( PubMed, DOI )

Hara Y, Ando F, Oikawa D, Ichimura K, Yanagawa H, Sakamaki Y, Nanamatsu A, Fujiki T, Mori S, Suzuki S, Yui N, Mandai S, Susa K, Mori T, Sohara E, Rai T, Takahashi M, Sasaki S, Kagechika H, Tokunaga F, Uchida S. LRBA is essential for urinary concentration and body water homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 2022.07; 119 (30): e2202125119. ( PubMed, DOI )

Oki Y, Katsuma A, Okabe M, Watanabe M, Sagasaki M, Takahashi D, Kimura A, Kato J, Ueda H, Hataya H, Fujimaru T, Mori T, Sohara E, Uchida S, Miyazaki Y, Yokoo T. Different Clinical Courses of Nephronophthisis in Dizygotic Twins. Internal medicine (Tokyo, Japan). 2022.06; ( PubMed, DOI )

Iio K, Mori T, Bessho S, Imai Y, Hatanaka M, Omori H, Kouhara H, Chiga M, Sohara E, Uchida S, Kaimori JY. Gitelman syndrome with a novel frameshift variant in SLC12A3 gene accompanied by chronic kidney disease and type 2 diabetes mellitus. CEN case reports. 2022.05; 11 (2): 191-195. ( PubMed, DOI )

Shinichi Uchida, Takayasu Mori, Koichiro Susa, Eisei Sohara. NCC regulation by WNK signal cascade. Front Physiol. 2022; 13 1081261. ( PubMed, DOI )

Adya Saran Sinha, Tianying Wang, Miho Watanabe, Yasushi Hosoi, Eisei Sohara, Tenpei Akita, Shinichi Uchida, Atsuo Fukuda. conductance in layer V pyramidal neurons of mouse medial prefrontal cortex. Front Mol Neurosci. 2022; 15 856262. ( PubMed, DOI )

Shintaro Mandai, Tetsuo Yamada, Toshiki Uchihara, Tadatsune Iida, Takashi Ito, Hidehiko Sato, Keiko Sato, Yoshiko Chida, Katsuiku Hirokawa, Yumi Noda. Severe Dialysis-Related Amyloidosis Spared the Brain: An Autopsy Case of a Patient Receiving Hemodialysis for 41 Years. J Neuropathol Exp Neurol. 2021.10; 80 (10): 997-999. ( PubMed, DOI )

Sakurasawa Takatoshi, Ohkubo Atsushi, Hoshikawa Yuki, Yamauchi Daisuke, Yamamoto Hiroko, Seshima Hiroshi, Kurashima Naoki, Iimori Soichiro, Rai Tatemitsu, Uchida Shinichi, Naito Shotaro. Adjustment by hematocrit level in calculation of removal rate in therapeutic apheresis THERAPEUTIC APHERESIS AND DIALYSIS. 2021.08; 25 (4): 425-431. ( PubMed, DOI )

Sakurasawa Takatoshi, Ohkubo Atsushi, Hoshikawa Yuki, Yamauchi Daisuke, Yamamoto Hiroko, Seshima Hiroshi, Kurashima Naoki, Iimori Soichiro, Rai Tatemitsu, Uchida Shinichi, Naito Shotaro. 治療的アフェレーシスの除去率計算におけるヘマトクリット値による調整(Adjustment by hematocrit level in calculation of removal rate in therapeutic apheresis) Therapeutic Apheresis and Dialysis. 2021.08; 25 (4): 425-431. ( ichushi )

Fujii Shinya, Kikuchi Eriko, Suzuyama Honoka, Watanabe Yuko, Ishigami-Yuasa Mari, Masuno Hiroyuki, Mori Takayasu, Isobe Kiyoshi, Uchida Shinichi, Kagechika Hiroyuki. Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents CHEMMEDCHEM. 2021.07; 16 (18): 2817-2822. ( PubMed, DOI )

Kumagai A, Takeda S, Sohara E, Uchida S, Iijima H, Itakura A, Koya D, Kanasaki K. Dietary Magnesium Insufficiency Induces Salt-Sensitive Hypertension in Mice Associated With Reduced Kidney Catechol-O-Methyl Transferase Activity. Hypertension (Dallas, Tex. : 1979). 2021.07; 78 (1): 138-150. ( PubMed, DOI )

Nanamatsu A, Mori T, Ando F, Furusho T, Mandai S, Susa K, Sohara E, Rai T, Uchida S. Vasopressin Induces Urinary Uromodulin Secretion By Activating PKA (Protein Kinase A). Hypertension. 2021.06; 77 (6): 1953-1963. ( PubMed, DOI )

Shimohata H, Miyake Y, Yoshida Y, Usui J, Mori T, Sohara E, Uchida S, Hirayama K, Kobayashi M. LMX1B-associated nephropathy that showed myelin figures on electron microscopy. CEN case reports. 2021.06; 10 (4): 588-591. ( PubMed, DOI )

Fujimaru T, Kawanishi K, Mori T, Mishima E, Sekine A, Chiga M, Mizui M, Sato N, Yanagita M, Ooki Y, Nagahama K, Ohnuki Y, Hamano N, Watanabe S, Mochizuki T, Nagatsuji K, Tanaka K, Tsukamoto T, Tsushima H, Shimamoto M, Tsuji T, Kuyama T, Kawamoto S, Maki K, Katsuma A, Oishi M, Yamamoto K, Mandai S, Kikuchi H, Ando F, Mori Y, Susa K, Iimori S, Naito S, Rai T, Hoshino J, Ubara Y, Miyazaki M, Nagata M, Uchida S, Sohara E. Genetic Background and Clinicopathologic Features of Adult-onset Nephronophthisis. Kidney international reports. 2021.05; 6 (5): 1346-1354. ( PubMed, DOI )

Takahashi Naohiro, Kikuchi Hiroaki, Usui Ayaka, Furusho Taisuke, Fujimaru Takuya, Fujiki Tamami, Yanagi Tomoki, Matsuura Yoshiaki, Asano Kenichi, Yamamoto Kouhei, Ando Fumiaki, Susa Koichiro, Mandai Shintaro, Mori Takayasu, Rai Tatemitsu, Uchida Shinichi, Arita Makoto, Sohara Eisei. Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD2 in the kidney(和訳中) Clinical and Experimental Nephrology. 2021.05; 25 (5): 445-455. ( ichushi )

Takahashi Naohiro, Kikuchi Hiroaki, Usui Ayaka, Furusho Taisuke, Fujimaru Takuya, Fujiki Tamami, Yanagi Tomoki, Matsuura Yoshiaki, Asano Kenichi, Yamamoto Kouhei, Ando Fumiaki, Susa Koichiro, Mandai Shintaro, Mori Takayasu, Rai Tatemitsu, Uchida Shinichi, Arita Makoto, Sohara Eisei. Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD(2) in the kidney CLINICAL AND EXPERIMENTAL NEPHROLOGY. 2021.05; 25 (5): 445-455. ( DOI )

Tao K, Awazu M, Honda M, Shibata H, Mori T, Uchida S, Hasegawa T, Ishii T. An infant with congenital nephrogenic diabetes insipidus presenting with hypercalcemia and hyperphosphatemia. Endocrinology, diabetes & metabolism case reports. 2021.04; 2021 ( PubMed, DOI )

Oe Y, Mishima E, Mori T, Okamoto K, Honkura Y, Nagasawa T, Yoshida M, Sato H, Suzuki J, Ikeda R, Sohara E, Uchida S, Katori Y, Miyazaki M. A Novel Mutation in LMX1B (p.Pro219Ala) Causes Focal Segmental Glomerulosclerosis with Alport Syndrome-like Phenotype. Internal medicine (Tokyo, Japan). 2021.04; 60 (18): 2991-2996. ( PubMed, DOI )

Mori T, Chiga M, Fujimaru T, Kawamoto R, Mandai S, Nanamatsu A, Nomura N, Ando F, Susa K, Sohara E, Rai T, Uchida S. Phenotypic differences of mutation-negative cases in Gitelman syndrome clinically diagnosed in adulthood. Hum Mutat. 2021.03; 42 (3): 300-309. ( PubMed, DOI )

Hiroko Hashimoto, Satomi Shikuma, Shintaro Mandai, Susumu Adachi, Shinichi Uchida. Calcium-based phosphate binder use is associated with lower risk of osteoporosis in hemodialysis patients. Sci Rep. 2021.01; 11 (1): 1648. ( PubMed, DOI )

Umene Ryusuke, Kitamura Mineaki, Arai Hideyuki, Matsumura Kazuki, Ishimaru Yuka, Maeda Kanenori, Uramatsu Tadashi, Obata Yoko, Mori Takayasu, Sohara Eisei, Uchida Shinichi, Nishino Tomoya. 腎機能障害により悪化した2遺伝子性の塩類喪失性尿細管機能異常症を呈したBartter症候群(Bartter syndrome representing digenic-based salt-losing tubulopathies presumably accelerated by renal insufficiency) CEN Case Reports. 2020.11; 9 (4): 375-379. ( ichushi )

Furusho T, Uchida S, Sohara E. The WNK signaling pathway and salt-sensitive hypertension Hypertension Research. 2020.08; 43 (8): 733-743. ( ichushi )

Shoda W, Nomura N, Ando F, Tagashira H, Iwamoto T, Ohta A, Isobe K, Mori T, Susa K, Sohara E, Rai T, Uchida S. Sodium-calcium exchanger 1 is the key molecule for urinary potassium excretion against acute hyperkalemia PLoS One. 2020.06; 15 (6): e0235360. ( PubMed, DOI )

Furusho T, Sohara E, Mandai S, Kikuchi H, Takahashi N, Fujimaru T, Hashimoto H, Arai Y, Ando F, Zeniya M, Mori T, Susa K, Isobe K, Nomura N, Yamamoto K, Okado T, Rai T, Uchida S. Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease. Kidney Int. 2020.02; ( PubMed, DOI )

Kikuchi Hiroaki, Sasaki Emi, Nomura Naohiro, Mori Takayasu, Minamishima Yoji Andrew, Yoshizaki Yuki, Takahashi Naohiro, Furusho Taisuke, Arai Yohei, Mandai Shintaro, Yamashita Takahiro, Ando Fumiaki, Maejima Yasuhiro, Isobe Kiyoshi, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi, Sohara Eisei. Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease Kidney Int.. 2019.01; 95 (1): 123-137. ( PubMed, DOI )

Fujimaru T, Mori T, Sekine A, Mandai S, Chiga M, Kikuchi H, Ando F, Mori Y, Nomura N, Iimori S, Naito S, Okado T, Rai T, Hoshino J, Ubara Y, Uchida S, Sohara E. Kidney enlargement and multiple liver cyst formation implicate mutations in PKD1/2 in adult sporadic polycystic kidney disease Clin Genet. 2018.07; 94 (1): 125-131. ( DOI )

Ando F, Mori S, Yui N, Morimoto T, Nomura N, Sohara E, Rai T, Sasaki S, Kondo Y, Kagechika H, Uchida S. AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus Nat Commun. 2018.04; 9 (1): 1411. ( PubMed, DOI )

Sasaki E, Susa K, Mori T, Isobe K, Araki Y, Inoue Y, Yoshizaki Y, Ando F, Mori Y, Mandai S, Zeniya M, Takahashi D, Nomura N, Rai T, Uchida S, Sohara E. KLHL3 knockout mice reveal the physiological role of KLHL3 and the pathophysiology of pseudohypoaldosteronism type II caused by mutant KLHL3. Mol Cell Biol. 2017.04; 37 (7): ( PubMed, DOI )

Takahashi D, Mori T, Sohara E, Tanaka M, Chiga M, Inoue Y, Nomura N, Zeniya M, Ochi H, Takeda S, Suganami T, Rai T, Uchida S. WNK4 is an adipogenic factor and its deletion reduces diet-induced obesity in mice. EBioMedicine. 2017.04; 18 118-127. ( PubMed, DOI )

Nagata Soichiro, Ikegaya Naoki, Ogino Shuhei, Uchida Shinichi, Itaya Mikiko, Momita Aoi, Shinozaki Shingo, Ohura Masaharu, Kuriki Ken, Kono Satoshi, Miyajima Hiroaki, Hishida Akira. 無セルロプラスミン血症を呈する血液透析患者において甲状腺癌切除は赤血球産生刺激製剤への低反応性を改善する(The Resection of Thyroid Cancer Was Associated with the Resolution of Hyporesponsiveness to an Erythropoiesis-stimulating Agent in a Hemodialysis Patient with Aceruloplasminemia) Internal Medicine. 2017.04; 56 (7): 805-810. ( ichushi )

Shoda W, Nomura N, Ando F, Mori Y, Mori T, Sohara E, Rai T, Uchida S. Calcineurin inhibitors block sodium-chloride cotransporter dephosphorylation in response to high potassium intake. Kidney Int. 2017.02; 91 (2): 402-411. ( PubMed, DOI )

Ando F, Sohara E, Morimoto T, Yui N, Nomura N, Kikuchi E, Takahashi D, Mori T, Vandewalle A, Rai T, Sasaki S, Kondo Y, Uchida S. Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway. Nat Commun. 2016.11; 7 13636. ( PubMed, DOI )

Mandai S, Mori T, Sohara E, Rai T, Uchida S. Generation of hypertension-associated STK39 polymorphism knockin cell lines with the clustered regularly interspaced short palindromic repeats/Cas9 system. Hypertension. 2015.12; 66 (6): 1199-1206. ( PubMed, DOI )

Zeniya M, Morimoto N, Takahashi D, Mori Y, Mori T, Ando F, Araki Y, Yoshizaki Y, Inoue Y, Isobe K, Nomura N, Oi K, Nishida H, Sasaki S, Sohara E, Rai T, Uchida S. Kelch-Like Protein 2 mediates angiotensin II-With No Lysine 3 signaling in the regulation of vascular tonus. J Am Soc Nephrol. 2015.09; 26 (9): 2129-2138. ( PubMed, DOI )

Kikuchi E, Mori T, Zeniya M, Isobe K, Ishigami-Yuasa M, Fujii S, Kagechika H, Ishihara T, Mizushima T, Sasaki S, Sohara E, Rai T, Uchida S. Discovery of novel SPAK inhibitors that block WNK kinase signaling to cation chloride transporters. J Am Soc Nephrol. 2015.07; 26 (7): 1525-1536. ( PubMed, DOI )

Inoue Y, Sohara E, Kobayashi K, Chiga M, Rai T, Ishibashi K, Horie S, Su X, Zhou J, Sasaki S, Uchida S. Aberrant glycosylation and localization of polycystin-1 cause polycystic kidney in an AQP11 knockout model. J Am Soc Nephrol. 2014.12; 25 (12): 2789-2799. ( PubMed, DOI )

Susa K, Sohara E, Rai T, Zeniya M, Mori Y, Mori T, Chiga M, Nomura N, Nishida H, Takahashi D, Isobe K, Inoue Y, Takeishi K, Takeda N, Sasaki S, Uchida S. Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice. Hum Mol Genet. 2014.10; 23 (19): 5052-5060. ( PubMed, DOI )

Uchida S. Regulation of blood pressure and renal electrolyte balance by Cullin-RING ligases. Curr Opin Nephrol Hypertens. 2014.09; 23 (5): 487-493. ( PubMed, DOI )

Zeniya M, Sohara E, Kita S, Iwamoto T, Susa K, Mori T, Oi K, Chiga M, Takahashi D, Yang SS, Lin SH, Rai T, Sasaki S, Uchida S. Dietary salt intake regulates WNK3-SPAK-NKCC1 phosphorylation cascade in mouse aorta through angiotensin II. Hypertension. 2013.11; 62 (5): 872-878. ( PubMed, DOI )

Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, Chiga M, Kikuchi E, Nomura N, Mori Y, Matsuo Y, Murata T, Nomura S, Asano T, Kawaguchi H, Nonoyama S, Rai T, Sasaki S, Uchida S. Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension. Cell Rep. 2013.03; 3 (3): 858-868. ( PubMed, DOI )

Nishida H, Sohara E, Nomura N, Chiga M, Alessi DR, Rai T, Sasaki S, Uchida S. Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice. Hypertension. 2012.10; 60 (4): 981-990. ( PubMed, DOI )

Uchida S, Chiga M, Sohara E, Rai T, Sasaki S. Does a β2-adrenergic receptor-WNK4-Na-Cl co-transporter signal cascade exist in the in vivo kidney? Nat Med. 2012.09; 18 (9): 1324-5; author reply 1325. ( PubMed, DOI )

Lin SH, Yu IS, Jiang ST, Lin SW, Chu P, Chen A, Sytwu HK, Sohara E, Uchida S, Sasaki S, Yang SS. Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome. Proc Natl Acad Sci U S A. 2011.10; 108 (42): 17538-17543. ( PubMed, DOI )

Ohta A, Rai T, Yui N, Chiga M, Yang SS, Lin SH, Sohara E, Sasaki S, Uchida S. Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. Hum Mol Genet. 2009.10; 18 (20): 3978-3986. ( PubMed, DOI )

Yang SS, Morimoto T, Rai T, Chiga M, Sohara E, Ohno M, Uchida K, Lin SH, Moriguchi T, Shibuya H, Kondo Y, Sasaki S, Uchida S. Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab. 2007.05; 5 (5): 331-344. ( PubMed, DOI )

Sohara E, Rai T, Yang SS, Uchida K, Nitta K, Horita S, Ohno M, Harada A, Sasaki S, Uchida S. Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation. Proc Natl Acad Sci U S A. 2006.09; 103 (38): 14217-14222. ( PubMed, DOI )

Yamauchi K, Rai T, Kobayashi K, Sohara E, Suzuki T, Itoh T, Suda S, Hayama A, Sasaki S, Uchida S. Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins. Proc Natl Acad Sci U S A. 2004.03; 101 (13): 4690-4694. ( PubMed, DOI )

Matsumura Y, Uchida S, Kondo Y, Miyazaki H, Ko SB, Hayama A, Morimoto T, Liu W, Arisawa M, Sasaki S, Marumo F. Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel. Nat Genet. 1999.01; 21 (1): 95-98. ( PubMed, DOI )

Uchida S, Sasaki S, Nitta K, Uchida K, Horita S, Nihei H, Marumo F. Localization and functional characterization of rat kidney-specific chloride channel, ClC-K1. J Clin Invest. 1995.01; 95 (1): 104-113. ( PubMed, DOI )

Kawasaki M, Uchida S, Monkawa T, Miyawaki A, Mikoshiba K, Marumo F, Sasaki S. Cloning and expression of a protein kinase C-regulated chloride channel abundantly expressed in rat brain neuronal cells. Neuron. 1994.03; 12 (3): 597-604. ( PubMed, DOI )

Uchida S, Yamauchi A, Preston AS, Kwon HM, Handler JS. Medium tonicity regulates expression of the Na(+)- and Cl(-)-dependent betaine transporter in Madin-Darby canine kidney cells by increasing transcription of the transporter gene. J Clin Invest. 1993.04; 91 (4): 1604-1607. ( PubMed, DOI )

Fushimi K, Uchida S, Hara Y, Hirata Y, Marumo F, Sasaki S. Cloning and expression of apical membrane water channel of rat kidney collecting tubule. Nature. 1993.02; 361 (6412): 549-552. ( PubMed, DOI )

Uchida S, Sasaki S, Furukawa T, Hiraoka M, Imai T, Hirata Y, Marumo F. Molecular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medulla. J Biol Chem. 1993.02; 268 (6): 3821-3824. ( PubMed )

Uchida S, Kwon HM, Yamauchi A, Preston AS, Marumo F, Handler JS. Molecular cloning of the cDNA for an MDCK cell Na(+)- and Cl(-)-dependent taurine transporter that is regulated by hypertonicity. Proc Natl Acad Sci U S A. 1992.09; 89 (17): 8230-8234. ( PubMed, DOI )

Kwon HM, Yamauchi A, Uchida S, Preston AS, Garcia-Perez A, Burg MB, Handler JS. Cloning of the cDNa for a Na+/myo-inositol cotransporter, a hypertonicity stress protein. J Biol Chem. 1992.03; 267 (9): 6297-6301. ( PubMed )

Uchida S, Nakanishi T, Kwon HM, Preston AS, Handler JS. Taurine behaves as an osmolyte in Madin-Darby canine kidney cells. Protection by polarized, regulated transport of taurine. J Clin Invest. 1991.08; 88 (2): 656-662. ( PubMed, DOI )

Uchida S, Kwon HM, Preston AS, Handler JS. Expression of Madin-Darby canine kidney cell Na(+)-and Cl(-)-dependent taurine transporter in Xenopus laevis oocytes. J Biol Chem. 1991.05; 266 (15): 9605-9609. ( PubMed )

Uchida S, Endou H. Substrate specificity to maintain cellular ATP along the mouse nephron. Am J Physiol. 1988.11; 255 (5 Pt 2): F977-F983. ( PubMed, DOI )

高橋直宏, 蘇原映誠, 有田誠, 菊池寛昭, 安藤史顕, 須佐紘一郎, 萬代新太郎, 森崇寧, 頼建光, 内田信一. Alox15 knock-outマウスは、腎臓におけるPGD2の増加を介してCKDの腎障害及び線維化を改善する. 第64回日本腎臓学会学術総会 2021.06

Ando F, Uchida S. Development of Novel Therapeutic Strategies for Congenital NDI and Other PKA-Related Diseases. 第43回⽇本分⼦⽣物学会年会 2020.12 web

Adya Saran Sinha , Wang Tianying, Hosoi Yasushi, Sohara Eisei, Akita Tenpei, Uchida Shinichi, Fukuda Atsuo. WNK3キナーゼはマウス内側前頭前野のV層錐体神経細胞における内向き整流と細胞内クロライドを調節することで興奮を維持する(WNK3 kinase maintains basal excitability by regulating inward rectification and intracellular chloride in layer V pyramidal neurons of mouse medial prefrontal cortex). The Journal of Physiological Sciences 2020.03.01

Furusho T, Sohara E, Mandai S, Kikuchi H, Takahashi N, Fujimaru T, Hashimoto H, Arai Y, Ando F, Zeniya M, Mori T, Susa K, Isobe K, Nomura N, Yamamoto K, Okado T, Rai T, Uchida S. Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease. 第9回CKD frontier meeting 2020.02 名古屋

Sohara Eisei, Kikuchi Hiroaki, Uchida Shinichi. 腎機能の再生医療におけるNew Frontiers　慢性腎臓病におけるエネルギー状態感知不全(New Frontiers in Regenerative Medicine of Renal Function　Failure to sense energy depletion in chronic kidney disease). The Journal of Physiological Sciences 2019.06.01

Sinha Adya Saran, Wang Tianying, Hosoi Yasushi, Sohara Eisei, Akita Tenpei, Uchida Shinichi, Fukuda Atsuo. WNK3キナーゼによる前頭前皮質におけるニューロン興奮性の調節メカニズム(Mechanisms underlying WNK3 kinase mediated regulation of neuronal excitability in prefrontal cortex). The Journal of Physiological Sciences 2019.06.01

Uchida Shinichi. 生体システムの構築およびその破壊に関する統合的かつ理論的研究　慢性腎臓病に対するマルチオミックスなアプローチ(Integrative and theoretical research on the architecture of biological system and its disorder　Multi-omics approaches to chronic kidney disease). The Journal of Physiological Sciences 2018.03.01

Saran Saran Adya, Hosoi Yasushi, Sohara Eisei, Mutoh Hiroki, Akita Tenpei, Uchida Shinichi, Fukuda Atsuo. WNK3 kinaseはマウス前頭前皮質のV層錐体神経細胞における内向き整流性potassium電流を制御する(WNK3 kinase regulates inwardly rectifying potassium current in layer V pyramidal neurons of the mouse prefrontal cortex). The Journal of Physiological Sciences 2018.03.01

Shinichi Uchida. Translational researches in the field of water and electrolyte disorders. The annual meeting of the American Society of Nephrology 2017.11.02 New Orleans, USA

Daiei Takahashi, Takayasu Mori, Eisei Sohara, Motoko Chiga, Yuichi Inoue, Naohiro Nomura, Moko Zeniya, Tatemitsu Rai, and Shinichi Uchida. WNK4 regulates adipocyte differentiation in 3T3-L1 cells. The 47th Annual Meeting of American Society of Nephrology 2016.11.19

Takuya Fujimaru, Takayasu Mori, Shintaro Mandai, Motoko Chiga, Hiroaki Kikuchi, Fumiaki Ando, Yutaro Mori, Naohiro Nomura, Shotaro Naito, Tomokazu Okado, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara. Development of a Customized Diagnostic Panel for Targeted Exome Sequencing of Polycystic Kidney Diseases. Kidney Week 2016 2016.11.19

Yohei Arai, Eiichiro Kanda, Soichiro Iimori, Shotaro Naito, Yumi Noda, Sei Sasaki, Eisei Sohara, Tomokazu Okado, Tatemitsu Rai, Shinichi Uchida. Low White Blood Cell Count Is Independently Associated with the Progression of Chronic Kidney Disease in the Elderly: The CKD-ROUTE Study. The 49th Annual Meeting of American Society of Nephrology 2016.11.18

Wakana Shoda, Naohiro Nomura, Fumiaki Ando, Yutaro Mori, Takayasu Mori, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida. Calcineurin Rapidly Dephosphorylates Sodium-ChlorideCotransporter in Response to High Potassium Intake. The 49th Annual Meeting of American Society of nephrology. 2016.11.18

Yuki Yoshizaki, Eisei Sohara, Takayasu Mori, Eriko Kikuchi, Daiei Takahashi, Moko Zeniya, Yuya Araki, Yutaro Mori, Fumiaki Ando, Tatemitsu Rai, Shinichi Uchida.. Drug Repositioning Screening for Keap1-Nrf2 Binding Inhibitors by Using Fluorescent Correlation Spectroscopy. The 49th Annual Meeting of American Society of Nephrology 2016.11.18

Emi Sasaki, Koichiro Susa, Takayasu Mori, Kiyoshi Isobe, Yuya Araki, Yuichi Inoue, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara. Generation and Analysis of KLHL3 Knockout Mice. The 49th Annual Meeting of American Society of nephrology 2016.11.18

Yutaro Mori, Shintaro Mandai, Takayasu Mori, Eisei Sohara, Tatematsu Rai, Shinichi Uchida. Generation of p62/SQSTM1 (p62) KO Cell Lines Using CRISPR/Cas9 -The Role of p62 on WNK1 Regulation by Changes of Extracellular Potassium Concentration-. The 49th Annual Meeting of the American Society of Nephrology 2016.11.17

Zeniya M, Mori T, Yui N, Nomura N, Chiga M, Sohara E, Rai T, Uchida S.. The proteasome inhibitor bortezomib attenuates renal fibrosis in mice.. The 49th Annual Meeting of American Society of Nephrology 2016.11.15

Hiroaki Kikuchi, Naohiro Nomura, Yoji Andrew Minamishima, Tatemitsu Rai, Shinichi Uchida?and Eisei Sohara.. Targeted Metabolomic Analysis of Kidney from the Subtotal Nephrectomy Mouse Model of Chronic Kidney Disease. The 49th Annual Meeting of American Society of Nephrology. 2016.11.15

Wakana Shoda, Naohiro Nomura, Fumiaki Ando, Yutaro Mori, Takayasu Mori, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida. Calcineurin rapidly dephosphorylates sodium-chloride cotransporter in response to high potassium intake. 第26回御茶ノ水腎研究会 2016.10.27

Uchida Shinichi. The KLHL proteins, the WNKs and renal Na+ transport.. 8Th FAOPS (Federation of the Asian and Oceanian Physiological Societies) Congress 2015.11.23 Bangkok, Thailand

Takehara Eriko, Mandai Shintaro, Uchida Shinichi . Reversal of Dialysis-Dependent Renal Failure and Nephrotic Syndrome after Conservative Therapy in an Adult with Proliferative Glomerulonephritis with C3-Dominant Deposition. 2015.11.07 San Diego, USA