Personnel Information

写真a

AKIYAMA Yoshimitsu


Job title

Junior Associate Professor

Laboratory Phone number

+81-3-5803-5186

Research Areas, Keywords

Epigenetics, Colorectal cancer, Gastric cancer, Genetic alteration, HNPCC

Graduating School 【 display / non-display

  • Toho University, Faculty of Science, Biology, 1989, Graduated

Graduate School 【 display / non-display

  • University of Tsukuba, Graduate School, Division of Medical Science, Master's Course, 1993, Completed

Degree 【 display / non-display

  • Ph.D, Tokyo Medical and Dental University

Campus Career 【 display / non-display

  • 2003.08
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Advanced Therapeutic Sciences, Molecular Oncology, Junior Associate Professor
  • 2018.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Advanced Therapeutic Sciences, Molecular Oncology, Junior Associate Professor

Academic Society Affiliations 【 display / non-display

  • Japanese Cancer Association

  • American Association for Cancer Research

  • The Japanese Society for Epigenetics

  • The Molecular Biology Society of Japan

Research Areas 【 display / non-display

  • Pathological medical chemistry

  • Human pathology

 

Published Papers & Misc 【 display / non-display

  • Hiroaki Ono, Tomotaka Kato, Yoshiki Murase, Yutaro Nakamura, Yoshiya Ishikawa, Shuichi Watanabe, Keiichi Akahoshi, Toshiro Ogura, Kosuke Ogawa, Daisuke Ban, Atsushi Kudo, Yoshimitsu Akiyama, Shinji Tanaka, Hiromichi Ito, Minoru Tanabe. . C646 inhibits G2/M cell cycle-related proteins and potentiates anti-tumor effects in pancreatic cancer Scientific Reports. 2021.05; 11 (1): 10078.

  • Seol HS, Akiyama Y, Lee SE, Shimada S, Jang SJ.. Loss of miR-100 and miR-125b results in cancer stem cell properties through IGF2 upregulation in hepatocellular carcinoma. Scientific Reports.. 2020.12; 10 (1): 21412. ( DOI )

  • Yoshino J, Akiyama Y, Shimada S, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Yamaoka S, Tanabe M, Tanaka S. Loss of ARID1A induces a stemness gene ALDH1A1 expression with histone acetylation in the malignant subtype of cholangiocarcinoma. Carcinogenesis. 2020.07; 41 (6): 734-742. ( PubMed, DOI )

  • Asakawa Masahiro, Itoh Michiko, Suganami Takayoshi, Sakai Takeru, Kanai Sayaka, Shirakawa Ibuki, Yuan Xunmei, Hatayama Tomomi, Shimada Shu, Akiyama Yoshimitsu, Fujiu Katsuhito, Inagaki Yutaka, Manabe Ichiro, Yamaoka Shoji, Yamada Tetsuya, Tanaka Shinji, Ogawa Yoshihiro. Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis SCIENTIFIC REPORTS. 2019.12; 9 (1): 19601. ( PubMed, DOI )

  • Shuichi Watanabe, Shu Shimada, Yoshimitsu Akiyama, Yoshiya Ishikawa, Toshiro Ogura, Kosuke Ogawa, Hiroaki Ono, Yusuke Mitsunori, Daisuke Ban, Atsushi Kudo, Shoji Yamaoka, Minoru Tanabe, Shinji Tanaka. Loss of KDM6A characterizes a poor prognostic subtype of human pancreatic cancer and potentiates HDAC inhibitor lethality. Int. J. Cancer. 2019.07; 145 (1): 192-205. ( PubMed, DOI )

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Books etc 【 display / non-display

  • CANCER BIOLOGY ILLUSTRATED. 2019.09

Conference Activities & Talks 【 display / non-display

  • Shu Shimada, Yoshimitsu Akiyama, Shigeki Arii, Minoru Tanabe, Shinji Tanaka. Comprehensive molecular and immunological classification of hepatocellular carcinoma. The 56th Annual Meeting of Liver Cancer Study Group of Japan 2020.12.22 Online

  • Akiyama Y, Shimada S, Tanabe M, Tanaka S. Loss of ARID1A increases a stemness gene ALDH1A1 expression through histone acetylation change in cholangiocarcinoma. The 79th Annual Meeting of the Japanese Cancer Association 2020.10.01 Yokohama, Online

  • Shimada S, Akiyama Y, Tanabe M, Tanaka S. Loss of KDM6A characterizes a poor prognostic subtype of pancreatic cancer and potentiates HDAC inhibitor lethalit. . The 79th Annual Meeting of the Japanese Cancer Association 2020.10.01 Yokohama, Online

  • Yoshimitsu Akiyama, Shu Shimada, Shinji Tanaka. Overexpression of histone arginine methyltransferase PRMT6 contributes to prognosis and malignancy of gastric cancer. The 78th Annual Meeting of the Japanese Cancer Association 2019.09.27 Kyoto

  • Shu Shimada, Yoshimitsu Akiyama, Shinji Tanaka. Comprehensive molecular and immunological characterization of hepatocellular carcinoma. The78th Annual Meeting of the Japanese Cancer Association 2019.09.26 kyoto

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Patents 【 display / non-display

  • Hypermethylation of GATA-4 and GATA-5 transcription factor genes in cancer. (Oncomethylome Sciences SA)

    Patent Number: JHU 4309