Personnel Information

写真a

AKIYAMA Yoshimitsu


Job title

Junior Associate Professor

Laboratory Phone number

+81-3-5803-5186

Research Areas, Keywords

Epigenetics, Colorectal cancer, Gastric cancer, Genetic alteration, HNPCC

Graduating School 【 display / non-display

  • Toho University, Faculty of Science, Biology, 1989, Graduated

Graduate School 【 display / non-display

  • University of Tsukuba, Graduate School, Division of Medical Science, Master's Course, 1993, Completed

Degree 【 display / non-display

  • Ph.D, Tokyo Medical and Dental University

Campus Career 【 display / non-display

  • 2003.08
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Advanced Therapeutic Sciences, Molecular Oncology, Junior Associate Professor
  • 2018.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Advanced Therapeutic Sciences, Molecular Oncology, Junior Associate Professor

Academic Society Affiliations 【 display / non-display

  • Japanese Cancer Association

  • American Association for Cancer Research

  • The Japanese Society for Epigenetics

  • The Molecular Biology Society of Japan

Research Areas 【 display / non-display

  • Pathological medical chemistry

  • Human pathology

 

Published Papers & Misc 【 display / non-display

  • Shuichi Watanabe, Shu Shimada, Yoshimitsu Akiyama, Yoshiya Ishikawa, Toshiro Ogura, Kosuke Ogawa, Hiroaki Ono, Yusuke Mitsunori, Daisuke Ban, Atsushi Kudo, Shoji Yamaoka, Minoru Tanabe, Shinji Tanaka. Loss of KDM6A characterizes a poor prognostic subtype of human pancreatic cancer and potentiates HDAC inhibitor lethality. Int. J. Cancer. 2019.07; 145 (1): 192-205. ( PubMed, DOI )

  • Keisuke Okuno, Yoshimitsu Akiyama, Shu Shimada, Masatoshi Nakagawa, Toshiro Tanioka, Mikito Inokuchi, Shoji Yamaoka, Kazuyuki Kojima, Shinji Tanaka. Asymmetric dimethylation at histone H3 arginine 2 by PRMT6 in gastric cancer progression. Carcinogenesis. 2019.03; 40 (1): 15-26. ( PubMed, DOI )

  • Hiroshi Fukamachi, Seon-Kyu Kim, Jiwon Koh, Hye Seung Lee, Yasushi Sasaki, Kentaro Yamashita, Taketo Nishikawaji, Shu Shimada, Yoshimitsu Akiyama, Sun-Ju Byeon, Dong-Hyuck Bae, Keisuke Okuno, Masatoshi Nakagawa, Toshiro Tanioka, Mikito Inokuchi, Hiroshi Kawachi, Kiichiro Tsuchiya, Kazuyuki Kojima, Takashi Tokino, Yoshinobu Eishi, Yong Sung Kim, Woo Ho Kim, Yasuhito Yuasa, Shinji Tanaka. A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors. J. Exp. Clin. Cancer Res.. 2019.03; 38 (1): 127. ( PubMed, DOI )

  • Shu Shimada, Kaoru Mogushi, Yoshimitsu Akiyama, Takaki Furuyama, Shuichi Watanabe, Toshiro Ogura, Kosuke Ogawa, Hiroaki Ono, Yusuke Mitsunori, Daisuke Ban, Atsushi Kudo, Shigeki Arii, Minoru Tanabe, Jack R Wands, Shinji Tanaka. Comprehensive molecular and immunological characterization of hepatocellular carcinoma. EBioMedicine. 2019.02; 40 457-470. ( PubMed, DOI )

  • Akiyama Yoshimitsu, Shimada Shu, Tanabe Minoru, Tanaka Shinji. DAXX acts as a tumor suppressor through histone H3.3/H3K9me3 pathway in pancreatic neuroendocrine tumors CANCER SCIENCE. 2018.12; 109 1103.

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Books etc 【 display / non-display

  • CANCER BIOLOGY ILLUSTRATED. 2019.09

Conference Activities & Talks 【 display / non-display

  • Yoshimitsu Akiyama, Shu Shimada, Shinji Tanaka. Overexpression of histone arginine methyltransferase PRMT6 contributes to prognosis and malignancy of gastric cancer. The 78th Annual Meeting of the Japanese Cancer Association 2019.09.27 Kyoto

  • Shu Shimada, Yoshimitsu Akiyama, Shinji Tanaka. Comprehensive molecular and immunological characterization of hepatocellular carcinoma. The78th Annual Meeting of the Japanese Cancer Association 2019.09.26 kyoto

  • Asymmetric dimethylation at histone H3 arginine 2 by PRMT6 in gastric cancer progression. 2019.05.28

  • Yoshimitsu Akiyama, Shu Shimada, Minoru Tanabe, Shinji Tanaka. DAXX acts as a tumor suppressor through histone H3.3/H3K9me3 pathway in pancreatic neuroendocrine tumors. The 77th Annual Meeting of the Japanese Cancer Association 2018.09.29 Osaka

  • Yuki Mizuno, Shu Shimada, Yoshimitsu Akiyama, Shuichi Watanabe,Tomomi Aida, Kosuke Ogawa、Hiroaki Ono, Yusuke Mitsunori、Daisuke Ban, Atsushi Kudo, Shoji Yamaoka, Shinji Tanaka, Minoru Tanabe. DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma. Yuki Mizuno, Shu Shimada, Yoshimitsu Akiyama, Shuichi Watanabe,Tomomi Aida, Kosuke Ogawa、Hiroaki Ono, Yusuke Mitsunori、Daisuke Ban, Atsushi Kudo, Shoji Yamaoka, Shinji Tanaka, Minoru Tanabe 2018.09.28 Osaka

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Patents 【 display / non-display

  • Hypermethylation of GATA-4 and GATA-5 transcription factor genes in cancer. (Oncomethylome Sciences SA)

    Patent Number: JHU 4309