Yoshino J, Akiyama Y, Shimada S, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Yamaoka S, Tanabe M, Tanaka S. Loss of ARID1A induces a stemness gene ALDH1A1 expression with histone acetylation in the malignant subtype of cholangiocarcinoma. Carcinogenesis. 2020.07; 41 (6): 734-742. ( PubMed, DOI )

Asakawa Masahiro, Itoh Michiko, Suganami Takayoshi, Sakai Takeru, Kanai Sayaka, Shirakawa Ibuki, Yuan Xunmei, Hatayama Tomomi, Shimada Shu, Akiyama Yoshimitsu, Fujiu Katsuhito, Inagaki Yutaka, Manabe Ichiro, Yamaoka Shoji, Yamada Tetsuya, Tanaka Shinji, Ogawa Yoshihiro. Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis SCIENTIFIC REPORTS. 2019.12; 9 (1): 19601. ( PubMed, DOI )

Shuichi Watanabe, Shu Shimada, Yoshimitsu Akiyama, Yoshiya Ishikawa, Toshiro Ogura, Kosuke Ogawa, Hiroaki Ono, Yusuke Mitsunori, Daisuke Ban, Atsushi Kudo, Shoji Yamaoka, Minoru Tanabe, Shinji Tanaka. Loss of KDM6A characterizes a poor prognostic subtype of human pancreatic cancer and potentiates HDAC inhibitor lethality. Int. J. Cancer. 2019.07; 145 (1): 192-205. ( PubMed, DOI )

Hiroshi Fukamachi, Seon-Kyu Kim, Jiwon Koh, Hye Seung Lee, Yasushi Sasaki, Kentaro Yamashita, Taketo Nishikawaji, Shu Shimada, Yoshimitsu Akiyama, Sun-Ju Byeon, Dong-Hyuck Bae, Keisuke Okuno, Masatoshi Nakagawa, Toshiro Tanioka, Mikito Inokuchi, Hiroshi Kawachi, Kiichiro Tsuchiya, Kazuyuki Kojima, Takashi Tokino, Yoshinobu Eishi, Yong Sung Kim, Woo Ho Kim, Yasuhito Yuasa, Shinji Tanaka. A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors. J. Exp. Clin. Cancer Res.. 2019.03; 38 (1): 127. ( PubMed, DOI )

Keisuke Okuno, Yoshimitsu Akiyama, Shu Shimada, Masatoshi Nakagawa, Toshiro Tanioka, Mikito Inokuchi, Shoji Yamaoka, Kazuyuki Kojima, Shinji Tanaka. Asymmetric dimethylation at histone H3 arginine 2 by PRMT6 in gastric cancer progression. Carcinogenesis. 2019.03; 40 (1): 15-26. ( PubMed, DOI )

Shu Shimada, Kaoru Mogushi, Yoshimitsu Akiyama, Takaki Furuyama, Shuichi Watanabe, Toshiro Ogura, Kosuke Ogawa, Hiroaki Ono, Yusuke Mitsunori, Daisuke Ban, Atsushi Kudo, Shigeki Arii, Minoru Tanabe, Jack R Wands, Shinji Tanaka. Comprehensive molecular and immunological characterization of hepatocellular carcinoma. EBioMedicine. 2019.02; 40 457-470. ( PubMed, DOI )

Ueda H, Akiyama Y, Shimada S, Mogushi K, Serizawa M, Matsumura S, Mitsunori Y, Aihara A, Ban D, Ochiai T, Kudo A, Tanabe M, Tanaka S.. Tumor suppressor functions of DAXX through histone H3.3/H3K9me3 pathway in pancreatic NETs. Endocrine Related Cancer. 2018.06; 25 (6): 619-631.

Chiyonobu Norimichi, Shimada Shu, Akiyama Yoshimitsu, Mogushi Kaoru, Itoh Michiko, Akahoshi Keiichi, Matsumura Satoshi, Ogawa Kosuke, Ono Hiroaki, Mitsunori Yusuke, Ban Daisuke, Kudo Atsushi, Arii Shigeki, Suganami Takayoshi, Yamaoka Shoji, Ogawa Yoshihiro, Tanabe Minoru, Tanaka Shinji. Fatty Acid Binding Protein 4 (FABP4) Overexpression in Intratumoral Hepatic Stellate Cells within Hepatocellular Carcinoma with Metabolic Risk Factors AMERICAN JOURNAL OF PATHOLOGY. 2018.05; 188 (5): 1213-1224. ( PubMed, DOI )

Shu Shimada, Yoshimitsu Akiyama, Kaoru Mogushi, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiromi Nagasaki, Hiroshi Fukamachi, Yasuhito Yuasa, Shinji Tanaka. Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models. Br. J. Cancer. 2018.04; 118 (7): 972-984. ( PubMed, DOI )

Mizuno Yuki, Shimada Shu, Akiyama Yoshimitsu, Watanabe Shuichi, Aida Tomomi, Ogawa Kosuke, Ono Hiroaki, Mitsunori Yusuke, Ban Daisuke, Kudo Atsushi, Arii Shigeki, Yamaoka Shoji, Tanabe Minoru, Tanaka Shinji. DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma SCIENTIFIC REPORTS. 2018.01; 8 (1): 106. ( PubMed, DOI )

Ohata Y, Shimada S, Akiyama Y, Mogushi K, Ito H, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Tanabe M, Tanaka S. . Acquired resistance with epigenetic alterations under long-term anti-angiogenic therapy for hepatocellular carcinoma Molecular Cancer Therapeutics. 2017.06; 16 (6): 1155-1165. ( DOI )

Atsushi Oba, Shu Shimada, Yoshimitsu Akiyama, Taketo Nishikawaji, Kaoru Mogushi, Hiromitsu Ito, Satoshi Matsumura, Arihiro Aihara, Yusuke Mitsunori, Daisuke Ban, Takanori Ochiai, Atsushi Kudo, Hiroshi Asahara, Atsushi Kaida, Masahiko Miura, Minoru Tanabe, Shinji Tanaka. ARID2 modulates DNA damage response in human hepatocellular carcinoma cells. J. Hepatol.. 2017.05; 66 (5): 942-951. ( PubMed, DOI )

Oze I, Shimada S, Nagasaki H, Akiyama Y, Watanabe M, Yatabe Y, Matsuo K, Yuasa Y.. Plasma miR-103, miR-107, and miR-194 levels are not correlated with human diffuse gastric cancer. Journal of Cancer Research and Clinical Oncology. 2017.03; (143): 551-554.

Angel Diaz-Lagares, Ana B Crujeiras, Paula Lopez-Serra, Marta Soler, Fernando Setien, Ashish Goyal, Juan Sandoval, Yutaka Hashimoto, Anna Martinez-Cardús, Antonio Gomez, Holger Heyn, Catia Moutinho, Jesús Espada, August Vidal, Maria Paúles, Maica Galán, Núria Sala, Yoshimitsu Akiyama, María Martínez-Iniesta, Lourdes Farré, Alberto Villanueva, Matthias Gross, Sven Diederichs, Sonia Guil, Manel Esteller. Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer. Proc. Natl. Acad. Sci. U.S.A.. 2016.11; 113 (47): E7535-E7544.

Nishikawaji T, Akiyama Y, Shimada S, Kojima K, Kawano T, Eishi Y, Yuasa Y, Tanaka S. Oncogenic roles of the SETDB2 histone methyltransferase in gastric cancer. Oncotarget. 2016.10; 7 (41): 67251-67265. ( PubMed, DOI )

Akahoshi K, Tanaka S, Mogushi K, Shimada S, Matsumura S, Akiyama Y, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Arii S, Tanabe M.. Expression of connective tissue growth factor in the livers of non-viral hepatocellular carcinoma patients with metabolic risk factors. J Gastroenterol. . 2016.09; 51 (9): 910-922.

Furuyama T, Tanaka S, Shimada S, Akiyama Y, Matsumura S, Mitsunori Y, Aihara A, Ban D, Ochiai T, Kudo A, Fukamachi H, Arii S, Kawaguchi Y, Tanabe M. Proteasome activity is required for the initiation of precancerous pancreatic lesions. Sci Rep. 2016.05; 6 27044. ( PubMed, DOI )

Lentjes MH, Niessen HE, Akiyama Y, de Bruïne AP, Melotte V, van Engeland M. The emerging role of GATA transcription factors in development and disease. Expert Rev Mol Med. 2016.03; 18 e3. ( PubMed, DOI )

Katsuta E, Tanaka S, Mogushi K, Shimada S, Akiyama Y, Aihara A, Matsumura S, Mitsunori Y, Ban D, Ochiai T, Kudo A, Fukamachi H, Tanaka H, Nakayama K, Arii S, Tanabe M.. CD73 as a therapeutic target for pancreatic neuroendocrine tumor stem cells. Int J Oncol. . 2016.02; 48 (2): 657-669.

Akiyama Y, Koda Y, Byeon SJ, Shimada S, Nishikawaji T, Sakamoto A, Chen Y, Kojima K, Kawano T, Eishi Y, Deng D, Kim WH, Zhu WG, Yuasa Y, Tanaka S. Reduced expression of SET7/9, a histone mono-methyltransferase, is associated with gastric cancer progression. Oncotarget. 2016.01; 7 (4): 3966-3983. ( PubMed, DOI )

Ito H, Tanaka S, Akiyama Y, Shimada S, Adikrisna R, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Arii S, Yamaoka S, Tanabe M. Dominant Expression of DCLK1 in Human Pancreatic Cancer Stem Cells Accelerates Tumor Invasion and Metastasis. PLoS ONE. 2016.01; 11 (1): e0146564. ( PubMed, DOI )

Hyang Sook Seol, Yoshimitsu Akiyama, Shu Shimada, Hee Jin Lee, Tae Im Kim, Sung Min Chun, Shree Ram Singh, Se Jin Jang. Epigenetic silencing of microRNA-373 to epithelial-mesenchymal transition in non-small cell lung cancer through IRAK2 and LAMP1 axes. Cancer Lett.. 2014.10; 353 (2): 232-241. ( PubMed, DOI )

L Chen, L Fu, X Kong, J Xu, Z Wang, X Ma, Y Akiyama, Y Chen, J Fang. Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer. Br. J. Cancer. 2014.02; 110 (4): 1014-1026. ( PubMed, DOI )

秋山好光. 胃がん、エピジェネティクスと病気 遺伝子医学MOOK25. 2013.08; 25 64-69.

Yutaka Hashimoto, Yoshimitsu Akiyama, Yasuhito Yuasa. Multiple-to-multiple relationships between microRNAs and target genes in gastric cancer. PLoS ONE. 2013.05; 8 (5): e62589. ( PubMed, DOI )

Donglai Wang, Jingyi Zhou, Xiangyu Liu, Danyu Lu, Changchun Shen, Yipeng Du, Fu-Zheng Wei, Boyan Song, Xiaopeng Lu, Yu Yu, Lina Wang, Ying Zhao, Haiying Wang, Yang Yang, Yoshimitsu Akiyama, Hongquan Zhang, Wei-Guo Zhu. Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability. Proc. Natl. Acad. Sci. U.S.A.. 2013.04; 110 (14): 5516-5521. ( PubMed, DOI )

P Rotkrua, S Shimada, K Mogushi, Y Akiyama, H Tanaka, Y Yuasa. Circulating microRNAs as biomarkers for early detection of diffuse-type gastric cancer using a mouse model. Br. J. Cancer. 2013.03; 108 (4): 932-940. ( PubMed, DOI )

Yasuhito Yuasa, Hiromi Nagasaki, Isao Oze, Yoshimitsu Akiyama, Shunsuke Yoshida, Kouhei Shitara, Seiji Ito, Satoyo Hosono, Miki Watanabe, Hidemi Ito, Hideo Tanaka, Daehee Kang, Kai-Feng Pan, Wei-Cheng You, Keitaro Matsuo. Insulin-like growth factor 2 hypomethylation of blood leukocyte DNA is associated with gastric cancer risk. Int. J. Cancer. 2012.12; 131 (11): 2596-2603. ( PubMed, DOI )

秋山好光、湯浅保仁. マイクロRNA発現異常とがん Medical Science Digest. 2012.03; 38 (3): 102-105.

Shu Shimada, Ayako Mimata, Masaki Sekine, Kaoru Mogushi, Yoshimitsu Akiyama, Hiroshi Fukamachi, Jos Jonkers, Hiroshi Tanaka, Yoshinobu Eishi, Yasuhito Yuasa. Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer. Gut. 2012.03; 61 (3): 344-353. ( PubMed, DOI )

Pichayanoot Rotkrua, Yoshimitsu Akiyama, Yutaka Hashimoto, Takeshi Otsubo, Yasuhito Yuasa. MiR-9 downregulates CDX2 expression in gastric cancer cells. Int. J. Cancer. 2011.12; 129 (11): 2611-2620. ( PubMed, DOI )

秋山好光. miRNAを利用した癌診断 医学のあゆみ. 2011.07; 238 (5): 560-565.

秋山好光、橋本裕、湯浅保仁. microRNA発現プロファイルの胃癌診断への応用 胃がんperspective. 2011.03; 4 (1): 12-19.

Takeshi Otsubo, Yoshimitsu Akiyama, Yutaka Hashimoto, Shu Shimada, Kentaro Goto, Yasuhito Yuasa. MicroRNA-126 inhibits SOX2 expression and contributes to gastric carcinogenesis. PLoS ONE. 2011.01; 6 (1): e16617. ( PubMed, DOI )

Rie Wada, Yoshimitsu Akiyama, Yutaka Hashimoto, Hiroshi Fukamachi, Yasuhito Yuasa. miR-212 is downregulated and suppresses methyl-CpG-binding protein MeCP2 in human gastric cancer. Int. J. Cancer. 2010.09; 127 (5): 1106-1114. ( PubMed, DOI )

Yutaka Hashimoto, Yoshimitsu Akiyama, Takeshi Otsubo, Shu Shimada, Yasuhito Yuasa. Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis. Carcinogenesis. 2010.05; 31 (5): 777-784. ( PubMed, DOI )

Xian-Zi Wen, Yoshimitsu Akiyama, Kai-Feng Pan, Zhao-Jun Liu, Zhe-Ming Lu, Jing Zhou, Lian-Kun Gu, Cai-Xuan Dong, Bu-Dong Zhu, Jia-Fu Ji, Wei-Cheng You, Da-Jun Deng. Methylation of GATA-4 and GATA-5 and development of sporadic gastric carcinomas. World J. Gastroenterol.. 2010.03; 16 (10): 1201-1208. ( PubMed )

Debby M E I Hellebrekers, Marjolein H F M Lentjes, Sandra M van den Bosch, Veerle Melotte, Kim A D Wouters, Kathleen L J Daenen, Kim M Smits, Yoshimitsu Akiyama, Yasuhito Yuasa, Silvia Sanduleanu, Carolina A J Khalid-de Bakker, Daisy Jonkers, Matty P Weijenberg, Joost Louwagie, Wim van Criekinge, Beatriz Carvalho, Gerrit A Meijer, Stephen B Baylin, James G Herman, Adriaan P de Bruïne, Manon van Engeland. GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer. Clin. Cancer Res.. 2009.06; 15 (12): 3990-3997. ( PubMed, DOI )

Yasuhito Yuasa, Hiromi Nagasaki, Yoshimitsu Akiyama, Yutaka Hashimoto, Touichirou Takizawa, Kazuyuki Kojima, Tatsuyuki Kawano, Kenichi Sugihara, Kazue Imai, Kei Nakachi. DNA methylation status is inversely correlated with green tea intake and physical activity in gastric cancer patients. Int. J. Cancer. 2009.06; 124 (11): 2677-2682. ( PubMed, DOI )

Aira Wanajo, Akane Sasaki, Hiromi Nagasaki, Shu Shimada, Takeshi Otsubo, Syuichi Owaki, Yasufumi Shimizu, Yoshinobu Eishi, Kazuyuki Kojima, Yasuaki Nakajima, Tatsuyuki Kawano, Yasuhito Yuasa, Yoshimitsu Akiyama. Methylation of the calcium channel-related gene, CACNA2D3, is frequent and a poor prognostic factor in gastric cancer. Gastroenterology. 2008.08; 135 (2): 580-590. ( PubMed, DOI )

Jin SH, Akiyama Y, Fukamachi H, Yanagihara K, Akashi T, Yuasa Y. IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells. Int J Cancer. 2008.03; 122 (5): 1040-1046. ( PubMed, DOI )

Otsubo T, Akiyama Y, Yanagihara K, Yuasa Y. SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis. Br J Cancer. 2008.02; 98 (4): 824-831. ( PubMed, DOI )

Tani Y, Akiyama Y, Fukamachi H, Yanagihara K, Yuasa Y. Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression. J Cancer Res Clin Oncol. 2007.04; 133 (4): 263-269. ( PubMed, DOI )

Jinawath A, Akiyama Y, Sripa B, Yuasa Y. Dual blockade of the Hedgehog and ERK1/2 pathways coordinately decreases proliferation and survival of cholangiocarcinoma cells. J Cancer Res Clin Oncol. 2007.04; 133 (4): 271-278. ( PubMed, DOI )

Jinawath A, Akiyama Y, Yuasa Y, Pairojkul C. Expression of phosphorylated ERK1/2 and homeodomain protein CDX2 in cholangiocarcinoma. J Cancer Res Clin Oncol. 2006.12; 132 (12): 805-810. ( PubMed, DOI )

Guo M, House MG, Akiyama Y, Qi Y, Capagna D, Harmon J, Baylin SB, Brock MV, Herman JG. Hypermethylation of the GATA gene family in esophageal cancer. Int J Cancer. 2006.11; 119 (9): 2078-2083. ( PubMed, DOI )

Wakana K, Akiyama Y, Aso T, Yuasa Y. Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis. Cancer Lett. 2006.09; 241 (2): 281-288. ( PubMed, DOI )

Sekine A, Akiyama Y, Yanagihara K, Yuasa Y. Hath1 up-regulates gastric mucin gene expression in gastric cells. Biochem Biophys Res Commun. 2006.06; 344 (4): 1166-1171. ( PubMed, DOI )

Wen XZ, Akiyama Y, Baylin SB, Yuasa Y. Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas. Oncogene. 2006.04; 25 (18): 2666-2673. ( PubMed, DOI )

Galm O, Suzuki H, Akiyama Y, Esteller M, Brock MV, Osieka R, Baylin SB, Herman JG. Inactivation of the tissue inhibitor of metalloproteinases-2 gene by promoter hypermethylation in lymphoid malignancies. Oncogene. 2005.07; 24 (30): 4799-4805. ( PubMed, DOI )

Wu XS, Akiyama Y, Igari T, Kawamura T, Hiranuma S, Shibata T, Tsuruta K, Koike M, Arii S, Yuasa Y. Expression of homeodomain protein CDX2 in gallbladder carcinomas. J Cancer Res Clin Oncol. 2005.05; 131 (5): 271-278. ( PubMed, DOI )

Yuasa Y, Nagasaki H, Akiyama Y, Sakai H, Nakajima T, Ohkura Y, Takizawa T, Koike M, Tani M, Iwai T, Sugihara K, Imai K, Nakachi K. Relationship between CDX2 gene methylation and dietary factors in gastric cancer patients. Carcinogenesis. 2005.01; 26 (1): 193-200. ( PubMed, DOI )

Jinawath A, Miyake S, Yanagisawa Y, Akiyama Y, Yuasa Y. Transcriptional regulation of the human DNA methyltransferase 3A and 3B genes by Sp3 and Sp1 zinc finger proteins. Biochem J. 2005.01; 385 (Pt 2): 557-564. ( PubMed, DOI )

Guo M, Akiyama Y, House MG, Hooker CM, Heath E, Gabrielson E, Yang SC, Han Y, Baylin SB, Herman JG, Brock MV. Hypermethylation of the GATA genes in lung cancer. Clin Cancer Res. 2004.12; 10 (23): 7917-7924. ( PubMed, DOI )

Ren CY, Akiyama Y, Miyake S, Yuasa Y. Transcription factor GATA-5 selectively up-regulates mucin gene expression. J Cancer Res Clin Oncol. 2004.05; 130 (5): 245-252. ( PubMed, DOI )

Suzuki H, Watkins DN, Jair KW, Schuebel KE, Markowitz SD, Chen WD, Pretlow TP, Yang B, Akiyama Y, Van Engeland M, Toyota M, Tokino T, Hinoda Y, Imai K, Herman JG, Baylin SB. Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet. 2004.04; 36 (4): 417-422. ( PubMed, DOI )

Sakai H, Eishi Y, Li XL, Akiyama Y, Miyake S, Takizawa T, Konishi N, Tatematsu M, Koike M, Yuasa Y. PDX1 homeobox protein expression in pseudopyloric glands and gastric carcinomas. Gut. 2004.03; 53 (3): 323-330. ( PubMed )

Wen XZ, Miyake S, Akiyama Y, Yuasa Y. BMP-2 modulates the proliferation and differentiation of normal and cancerous gastric cells. Biochem Biophys Res Commun. 2004.03; 316 (1): 100-106. ( PubMed, DOI )

Douglas DB, Akiyama Y, Carraway H, Belinsky SA, Esteller M, Gabrielson E, Weitzman S, Williams T, Herman JG, Baylin SB. Hypermethylation of a small CpGuanine-rich region correlates with loss of activator protein-2alpha expression during progression of breast cancer. Cancer Res. 2004.03; 64 (5): 1611-1620. ( PubMed )

Li XL, Eishi Y, Bai YQ, Sakai H, Akiyama Y, Tani M, Takizawa T, Koike M, Yuasa Y. Expression of the SRY-related HMG box protein SOX2 in human gastric carcinoma. Int J Oncol. 2004.02; 24 (2): 257-263. ( PubMed )

Akiyama Y, Watkins N, Suzuki H, Jair KW, van Engeland M, Esteller M, Sakai H, Ren CY, Yuasa Y, Herman JG, Baylin SB. GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer. Mol Cell Biol. 2003.12; 23 (23): 8429-8439. ( PubMed )

Brock MV, Gou M, Akiyama Y, Muller A, Wu TT, Montgomery E, Deasel M, Germonpre P, Rubinson L, Heitmiller RF, Yang SC, Forastiere AA, Baylin SB, Herman JG. Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinoma. Clin Cancer Res. 2003.08; 9 (8): 2912-2919. ( PubMed )

Bai YQ, Yamamoto H, Akiyama Y, Tanaka H, Takizawa T, Koike M, Kenji Yagi O, Saitoh K, Takeshita K, Iwai T, Yuasa Y. Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach. Cancer Lett. 2002.02; 176 (1): 47-55. ( PubMed )

Esteller M, Fraga MF, Guo M, Garcia-Foncillas J, Hedenfalk I, Godwin AK, Trojan J, Vaurs-Barriere C, Bignon YJ, Ramus S, Benitez J, Caldes T, Akiyama Y, Yuasa Y, Launonen V, Canal MJ, Rodriguez R, Capella G, Peinado MA, Borg A, Aaltonen LA, Ponder BA, Baylin SB, Herman JG. DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. Hum Mol Genet. 2001.12; 10 (26): 3001-3007. ( PubMed )

Nakajima T, Akiyama Y, Shiraishi J, Arai T, Yanagisawa Y, Ara M, Fukuda Y, Sawabe M, Saitoh K, Kamiyama R, Hirokawa K, Yuasa Y. Age-related hypermethylation of the hMLH1 promoter in gastric cancers. Int J Cancer. 2001.10; 94 (2): 208-211. ( PubMed )

Akiyama Y, Nagasaki H, Nakajima T, Sakai H, Nomizu T, Yuasa Y. Infrequent frameshift mutations in the simple repeat sequences of hMLH3 in hereditary nonpolyposis colorectal cancers. Jpn J Clin Oncol. 2001.02; 31 (2): 61-64. ( PubMed )

Sato Y, Akiyama Y, Tanizawa T, Shibata T, Saito K, Mori S, Kamiyama R, Yuasa Y. Molecular characterization of the genomic breakpoint junction in the t(11;18) (q21;q21) translocation of a gastric MALT lymphoma. Biochem Biophys Res Commun. 2001.01; 280 (1): 301-306. ( PubMed, DOI )

Akiyama Y, Nagasaki H, Yagi KO, Nomizu T, Yuasa Y. Beta-catenin and adenomatous polyposis coli (APC) mutations in adenomas from hereditary non-polyposis colorectal cancer patients. Cancer Lett. 2000.09; 157 (2): 185-191. ( PubMed )

Iida S, Akiyama Y, Nakajima T, Ichikawa W, Nihei Z, Sugihara K, Yuasa Y. Alterations and hypermethylation of the p14(ARF) gene in gastric cancer. Int J Cancer. 2000.09; 87 (5): 654-658. ( PubMed )

Bai Y, Akiyama Y, Nagasaki H, Yagi OK, Kikuchi Y, Saito N, Takeshita K, Iwai T, Yuasa Y. Distinct expression of CDX2 and GATA4/5, development-related genes, in human gastric cancer cell lines. Mol Carcinog. 2000.07; 28 (3): 184-188. ( PubMed )

Furihata M, Shuin T, Takeuchi T, Sonobe H, Ohtsuki Y, Akiyama Y, Yuasa Y. Missense mutation of the hMSH6 and p53 genes in sporadic urothelial transitional cell carcinoma. Int J Oncol. 2000.03; 16 (3): 491-496. ( PubMed )

Yanagisawa Y, Akiyama Y, Iida S, Ito E, Nomizu T, Sugihara K, Yuasa Y, Maruyama K. Methylation of the hMLH1 promoter in familial gastric cancer with microsatellite instability. Int J Cancer. 2000.01; 85 (1): 50-53. ( PubMed )

Akiyama Y, Arai T, Nagasaki H, Yagi OK, Nakahata A, Nakajima T, Ohkura Y, Iwai T, Saitoh K, Yuasa Y. Frequent allelic imbalance on chromosome 18q21 in early superficial colorectal cancers. Jpn J Cancer Res. 1999.12; 90 (12): 1329-1337. ( PubMed )

Arai T, Akiyama Y, Nagasaki H, Murase N, Okabe S, Ikeuchi T, Saito K, Iwai T, Yuasa Y. EXTL3/EXTR1 alterations in colorectal cancer cell lines. Int J Oncol. 1999.11; 15 (5): 915-919. ( PubMed )

Bai YQ, Akiyama Y, Nagasaki H, Lu SL, Arai T, Morisaki T, Kitamura M, Muto A, Nagashima M, Nomizu T, Iwama T, Itoh H, Baba S, Iwai T, Yuasa Y. Predominant germ-line mutation of the hMSH2 gene in Japanese hereditary non-polyposis colorectal cancer kindreds. Int J Cancer. 1999.08; 82 (4): 512-515. ( PubMed )

Iida S, Akiyama Y, Ichikawa W, Yamashita T, Nomizu T, Nihei Z, Sugihara K, Yuasa Y. Infrequent germ-line mutation of the E-cadherin gene in Japanese familial gastric cancer kindreds. Clin Cancer Res. 1999.06; 5 (6): 1445-1447. ( PubMed )

Ito E, Yanagisawa Y, Iwahashi Y, Suzuki Y, Nagasaki H, Akiyama Y, Sugano S, Yuasa Y, Maruyama K. A core promoter and a frequent single-nucleotide polymorphism of the mismatch repair gene hMLH1. Biochem Biophys Res Commun. 1999.03; 256 (3): 488-494. ( PubMed, DOI )

Yagi OK, Akiyama Y, Yuasa Y. Genomic structure and alterations of homeobox gene CDX2 in colorectal carcinomas. Br J Cancer. 1999.02; 79 (3-4): 440-444. ( PubMed, DOI )

Arai T, Akiyama Y, Okabe S, Saito K, Iwai T, Yuasa Y. Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas. Cancer Lett. 1998.11; 133 (2): 197-204. ( PubMed )

Arai T, Akiyama Y, Yamamura A, Hosoi T, Shibata T, Saitoh K, Okabe S, Yuasa Y. Allelotype analysis of early colorectal cancers with lymph node metastasis. Int J Cancer. 1998.08; 79 (4): 418-423. ( PubMed )

Iwahashi Y, Ito E, Yanagisawa Y, Akiyama Y, Yuasa Y, Onodera T, Maruyama K. Promoter analysis of the human mismatch repair gene hMSH2. Gene. 1998.06; 213 (1-2): 141-147. ( PubMed )

Lu SL, Kawabata M, Imamura T, Akiyama Y, Nomizu T, Miyazono K, Yuasa Y. HNPCC associated with germline mutation in the TGF-beta type II receptor gene. Nat Genet. 1998.05; 19 (1): 17-18. ( PubMed, DOI )

Akiyama Y, Yagi OK, Ishikawa T, Nagasaki H, Saitoh K, Yuasa Y. Genetic alterations are frequent in APC but rare in the TGF-beta type II receptor gene in cancer in adenomas of the colon. Cancer Lett. 1998.03; 125 (1-2): 89-96. ( PubMed )

Yagi OK, Akiyama Y, Nomizu T, Iwama T, Endo M, Yuasa Y. Proapoptotic gene BAX is frequently mutated in hereditary nonpolyposis colorectal cancers but not in adenomas. Gastroenterology. 1998.02; 114 (2): 268-274. ( PubMed )

Yanagisawa Y, Ito E, Iwahashi Y, Akiyama Y, Yuasa Y, Maruyama K. Isolation and characterization of the 5' region of the human mismatch repair gene hPMS1. Biochem Biophys Res Commun. 1998.02; 243 (3): 738-743. ( PubMed, DOI )

Arai T, Akiyama Y, Okabe S, Ando M, Endo M, Yuasa Y. Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers. Cancer Lett. 1998.01; 122 (1-2): 157-163. ( PubMed )

Akiyama Y, Sato H, Yamada T, Nagasaki H, Tsuchiya A, Abe R, Yuasa Y. Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred. Cancer Res. 1997.09; 57 (18): 3920-3923. ( PubMed )

Yagi OK, Akiyama Y, Ohkura Y, Ban S, Endo M, Saitoh K, Yuasa Y. Analyses of the APC and TGF-beta type II receptor genes, and microsatellite instability in mucosal colorectal carcinomas. Jpn J Cancer Res. 1997.08; 88 (8): 718-724. ( PubMed )

Akiyama Y, Tsubouchi N, Yuasa Y. Frequent somatic mutations of hMSH3 with reference to microsatellite instability in hereditary nonpolyposis colorectal cancers. Biochem Biophys Res Commun. 1997.07; 236 (2): 248-252. ( PubMed, DOI )

Akiyama Y, Iwanaga R, Saitoh K, Shiba K, Ushio K, Ikeda E, Iwama T, Nomizu T, Yuasa Y. Transforming growth factor beta type II receptor gene mutations in adenomas from hereditary nonpolyposis colorectal cancer. Gastroenterology. 1997.01; 112 (1): 33-39. ( PubMed )

Akiyama Y, Iwanaga R, Ishikawa T, Sakamoto K, Nishi N, Nihei Z, Iwama T, Saitoh K, Yuasa Y. Mutations of the transforming growth factor-beta type II receptor gene are strongly related to sporadic proximal colon carcinomas with microsatellite instability. Cancer. 1996.12; 78 (12): 2478-2484. ( PubMed )

Lu SL, Zhang WC, Akiyama Y, Nomizu T, Yuasa Y. Genomic structure of the transforming growth factor beta type II receptor gene and its mutations in hereditary nonpolyposis colorectal cancers. Cancer Res. 1996.10; 56 (20): 4595-4598. ( PubMed )

Hori H, Miyake S, Akiyama Y, Endo M, Yuasa Y. Clonal heterogeneity in human esophageal squamous cell carcinomas on DNA analysis. Jpn J Cancer Res. 1996.09; 87 (9): 923-929. ( PubMed )

Akiyama Y, Nakasaki H, Nihei Z, Iwama T, Nomizu T, Utsunomiya J, Yuasa Y. Frequent microsatellite instabilities and analyses of the related genes in familial gastric cancers. Jpn J Cancer Res. 1996.06; 87 (6): 595-601. ( PubMed )

Lu SL, Akiyama Y, Nagasaki H, Nomizu T, Ikeda E, Baba S, Ushio K, Iwama T, Maruyama K, Yuasa Y. Loss or somatic mutations of hMSH2 occur in hereditary nonpolyposis colorectal cancers with hMSH2 germline mutations. Jpn J Cancer Res. 1996.03; 87 (3): 279-287. ( PubMed )

Sasaki A, Nagashima M, Shiseki M, Katai H, Maruyama K, Iwanaga R, Akiyama Y, Yuasa Y, Yokota J. Microsatellite instability in gastric cancer prone families. Cancer Lett. 1996.02; 99 (2): 169-175. ( PubMed )

Lu SL, Akiyama Y, Nagasaki H, Saitoh K, Yuasa Y. Mutations of the transforming growth factor-beta type II receptor gene and genomic instability in hereditary nonpolyposis colorectal cancer. Biochem Biophys Res Commun. 1995.11; 216 (2): 452-457. ( PubMed, DOI )

Oto M, Suehiro T, Akiyama Y, Yuasa Y. Microsatellite instability in cancer identified by non-gel sieving capillary electrophoresis. Clin Chem. 1995.03; 41 (3): 482-483. ( PubMed )

秋山好光, 斎藤澄, 大倉康男, 伴慎一, 中村恭一. PCNA発現を指標としたヒト胃癌の増殖動態の研究-画像解析による定量的検討の試み- 胃と腸. 1995.01; 30 (1): 113-119.

Wu C, Akiyama Y, Imai K, Miyake S, Nagasaki H, Oto M, Okabe S, Iwama T, Mitamura K, Masumitsu H, et al.. DNA alterations in cells from hereditary non-polyposis colorectal cancer patients. Oncogene. 1994.03; 9 (3): 991-994. ( PubMed )

島田 周, 秋山 好光, 田中 真二. CRISPR/Cas9システムを用いたエクソンスキッピングによるβ-cateninシグナルの内在性活性化が肝がん細胞の免疫回避に寄与する(Intrinsic activation of β-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to immune evasion in HCC). 日本癌学会総会記事 2022.09.01

秋山 好光, 島田 周, 田邉 稔, 田中 真二. 膵癌におけるヒストンH3K4メチル化酵素SETD1A発現の臨床的及び生物学的意義(Prognostic and biological significance of overexpression of SEID1A histone H3K4 methyltransferase in pancreatic cancer). 日本癌学会総会記事 2022.09.01

秋山好光, 吉野潤, 島田周, 田邊稔, 田中真二. ARID1A欠失胆管癌における幹細胞遺伝子ALDH1A1の発現亢進とヒストン修飾変化の関与. 第22回日本肝がん分子標的治療研究会 2020.11.14 金沢

島田 周, 秋山 好光, 田邉 稔, 田中 真二. KDM6A発現低下を特徴とする膵がん予後不良サブタイプにはHDAC阻害剤が著効する. 日本癌学会総会記事 2020.10.01

秋山 好光, 島田 周, 田邉 稔, 田中 真二. 胆管癌におけるARID1A欠失はヒストンアセチル化を介して幹細胞遺伝子ALDH1A1の発現亢進に働く. 日本癌学会総会記事 2020.10.01

島田 周, 秋山 好光, 田中 真二. 肝細胞癌の分子生物学的および免疫学的分類(Comprehensive molecular and immunological characterization of hepatocellular carcinoma). 日本癌学会総会記事 2019.09.01

秋山 好光, 島田 周, 田中 真二. 胃癌におけるヒストンアルギニンメチル化タンパク質PRMT6の高発現は予後と悪性度に関与する(Overexpression of histone arginine methyltransferase PRMT6 contributes to prognosis and malignancy of gastric cancer). 日本癌学会総会記事 2019.09.01

Yuki Mizuno, Shu Shimada, Yoshimitsu Akiyama, Shuichi Watanabe,Tomomi Aida, Kosuke Ogawa、Hiroaki Ono, Yusuke　Mitsunori、Daisuke Ban, Atsushi Kudo, Shoji Yamaoka, Shinji Tanaka, Minoru Tanabe. DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma. Yuki Mizuno, Shu Shimada, Yoshimitsu Akiyama, Shuichi Watanabe,Tomomi Aida, Kosuke Ogawa、Hiroaki Ono, Yusuke　Mitsunori、Daisuke Ban, Atsushi Kudo, Shoji Yamaoka, Shinji Tanaka, Minoru Tanabe 2018.09.28 Osaka

島田 周, 秋山 好光, 田邉 稔, 田中 真二. メタボリック関連肝癌の腫瘍内星細胞におけるFABP4発現亢進の意義(FABP4 overexpression in intratumoral hepatic stellate cells within hepatocellular carcinoma with metabolic risk factors). 日本癌学会総会記事 2018.09.01

秋山 好光, 島田 周, 田邉 稔, 田中 真二. 膵内分泌腫瘍においてDAXXはヒストンH3.3/H3K9トリメチル化を介して癌抑制因子として働く(DAXX acts as a tumor suppressor through histone H3.3/H3K9me3 pathway in pancreatic neuroendocrine tumors). 日本癌学会総会記事 2018.09.01

水野 裕貴, 島田 周, 秋山 好光, 渡邊 秀一, 相田 知海, 小川 康介, 小野 宏晃, 光法 雄介, 伴 大輔, 工藤 篤, 山岡 昇司, 田中 真二, 田邉 稔. 肝細胞癌においてDEPDC5不活化はp62発現上昇を介してロイシン欠乏に対する抵抗性の獲得に寄与する(DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma). 日本癌学会総会記事 2018.09.01

深町 博史, 西川路 武人, 島田 周, 秋山 好光, 湯浅 保仁, 土屋 輝一郎, 田中 真二. 低分化型胃がんは、形成過程の異なる2つのクラスターに分類できる(Diffuse-type gastric cancers are classified into two clusters, which may be formed via different carcinogenic pathways). 日本癌学会総会記事 2018.09.01

Shuichi Watanabe、Shu Shimada、Yoshimitsu Akiyama、Kosuke Ogawa、Hiroaki Ono、Yusuke Mitsunori、Daisuke Ban、Atsushi Kudo、Minoru Tanabe、Shinji Tanaka. Precision medicine for the poorest prognosis subtype of pancreatic cancer. The 73rd General Meeting of the Japanese Society of Gastroenterological Surgery 2018.07.12 Kagoshima

Akiyama Y, Nishikawaji T, Shimada S, Yuasa Y, Tanaka S.. Molecular mechanisms of SETDB2 histone methyltransferase overexpression in gastric cancer.. 第76回日本癌学会総会 2017.09.30 横浜

Fukamachi H, Nishikawaji T, Shimada S, Akiyama Y, Yuasa Y, Tsuchiya K, Tanaka S. . Identification of signal transduction pathway in PDX-derived diffuse-type gastric tumor-initiating cells.. 第76回日本癌学会総会 2017.09.30 横浜

Shimada S, Akiyama Y, Tanaka S.. Acquired resistance with epigenetic alterations under long-term anti-angiogenic therapy for hepatocellular carcinoma.. 第76回日本癌学会総会 2017.09.28 横浜

深町 博史, 西川路 武人, 島田 周, 秋山 好光, 湯浅 保仁, 土屋 輝一郎, 田中 真二. 低分化型胃がん幹細胞の増殖制御機構　患者由来がん幹細胞の初代培養系を用いた同定. 日本癌学会総会記事 2017.09.01

秋山 好光, 西川路 武人, 島田 周, 湯浅 保仁, 田中 真二. 胃がんにおけるヒストンメチル化酵素SETDB2高発現の分子機構. 日本癌学会総会記事 2017.09.01

島田 周, 秋山 好光, 田中 真二. 肝細胞がんにおける血管新生阻害療法に対する耐性獲得とエピジェネティクス変化. 日本癌学会総会記事 2017.09.01

Akiyama Y, Nishikawaji T, Shimada S, Deng D, Kim WH, Zhu WG, Yuasa Y, Tanaka S. Expression changes of the histone H3 lysine methyltransferase genes and their function in gastric cancer. 5th International Cancer Epigenetics Meeting 2016.10.22 Beijing, China

Akiyama Y, Nishikawaji T, Shimada S, Yuasa Y, Tanaka S. Expression changes of the histone methyltransferase genes, SETDB2, in gastric cancers. 26th Seoul International Cancer Symposium 2016.06.17 Seoul, Korea

Fukamachi H, Nishikawaji T, Shimada S, Akiyama Y, Yuasa Y, Tsuchiya K, Tanaka S. Characteristics of diffuse-type gastric cancer stem cells. 26th Seoul International Cancer Symposium 2016.06.17 Seoul, Korea

Akiyama Y, Nishikawaji T, Shimada S, Sakamoto A, Deng D, Kim WH, Zhu WG, Yuasa Y Tanaka S. Reduced expression and its function of SET7/9, a histone methyltransferase gene, in gastric cancer. The 35th Sapporo International Cancer Symposium 2016 2016.05.24

Shimada S, Akiyama Y, Fukamachi H, Yuasa Y, Tanaka S. Identification of selective inhibitors of diffuse-type gastric cancer cells by screening annotated compounds. AACR Annual Meeting 2016 2016.04.18 New Orleans, LA

Akiyama Y, Koda Y, Nishikawaji T, Shimada S, Deng D, Kim WH, Zhu WG, Yuasa Y. Altered expression of the histone methyltransferase genes in gastric cancer.. 4th International Cancer Epigenetics Meeting 2014.10.19 Yangzhou, China

Akiyama Y, Koda Y, Nishikawaji T, Shimada S, Zhu WG, Yuasa Y.. Loss of SET7, a histone H3K4 methyltransferase, in gastric cancer.. The 3rd International Cancer Epigenetics Meeting 2012.10 東京

Akiyama Y, Nagasaki H, Yuasa Y.. Target gene analysis of GATA4 and GATA5 transcription factors in gastric cancer cells.. The 10th Japan-Korea Joint Symposium on Cancer and Ageing 2012.02 東京

Akiyama Y, Nagasaki H, Yuasa Y. . Epigenetic alterations of GATA4 and GATA5 transcription factors in gastric cancers.. NRF A3 Foresight Program – IGCC2011 2011.04

Akiyama Y, Nagasaki H, Yuasa Y. . Hypermethylation of GATA4 and GATA5 transcription factor genes and loss of their functions in gastric cancers.. The Second International Cancer Epigenetics Symposium 2010.10

Akiyama Y, Nagasaki H, Yuasa Y. . Target gene analysis of GATA4/5 transcription factors in gastric cancers.. The 5th Asian Epigenomics Meeting & A3 Symposium 2010 2010.06 Jeju, 韓国

Akiyama Y, Nagasaki H, Kawamoto A, Herman JG, Baylin SB, Yuasa Y.. Methylation of GATA4 and GATA5 transcription factor genes in gastric cancers.. 101st AACR Annual Meeting 2010.04 Washington DC, USA

Akiyama Y, Hashimoto Y, Yuasa Y. . Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis.. The 9th Korea-Japan Symposium on Cancer and Ageing Research 2009.09 Damyang, 韓国

秋山好光、長崎弘美、湯浅保仁. . 胃がんにおける転写関連遺伝子GATA4/5のメチル化異常と機能解析.. 第3回日本エピジェネティクス研究会年会 2009.05 東京

Akiyama Y, Wanajo A, Otsubo T, Nagasaki H, Yuasa Y.. Promoter hypermethylation of the calcium channel-related gene, CACNA2D3, is frequent and an independently poor prognostic factor in gastric carcinomas.. AACR Annual Meeting 2008 2008.04 San Diego, USA

Akiyama Y, Yuasa Y. Hypermethylation of GATA4 and GATA5 transcription factor genes in gastric cancer. . The 12th Korea-Japan Cancer Research Workshop 2007.12

Akiyama Y, Nagasaki H, Kawamoto A, Yuasa Y. GATA4 and GATA5 transcription factor genes were frequently silenced by methylation in gastric cancer. . The 8th Korea-Japan Joint Symposium on Cancer and Ageing Research 2007.08 岐阜

秋山好光、和南城愛良、佐々木茜、長崎弘美、湯浅保仁. 胃癌における電位依存性カルシウムチャンネル関連遺伝子のメチル化の解析.. 第65回日本癌学会総会 2006.09 横浜

Akiyama Y, Wanajo A, Sasaki A, Yuasa Y. requent methylation of the calcium channel-related gene, CACNA2D3, in gastric cancers.. AACR, 97th Annual Meeting 2006.04 Washington DC, USA

Akiyama Y, Wen X-Z & Yuasa Y. Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas. . The 7th Korea-Japan Joint Symposium on Cancer and Ageing Research 2005.11 Muju, 韓国

Akiyama Y, Yuasa Y, Herman JG & Baylin SB. GATA–4 and GATA-5 transcription factor genes and potential downstream anti-tumor target genes are epigenetically silenced in colorectal and gastric cancer.. 6th Japan-Korea Workshop on Cancer and Aging Research 2004.02 徳島