Personnel Information

写真a

MORIO Tomohiro


Job title

Professor

Birth date

1958

Laboratory Phone number

+81-3-5803-5245

Laboratory Fax number

+81-3-5803-5245

Research Areas, Keywords

immunodeficiency, infection, class switching, DNA damage response, regenerative medicine

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Medicine, 1983, Graduated

Degree 【 display / non-display

  • MD, PhD

Campus Career 【 display / non-display

  • 2014.06
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Pediatrics and Developmental Biology, Professor
  • 2016.04
    -
    Now
    Tokyo Medical and Dental University, Medical Hospital, Hospital Departments, Department of Pediatrics, Maternal and Woman's Medicine, Director
  • 2016.04
    -
    Now
    Tokyo Medical and Dental University, Medical Hospital, Director
  • 2016.10
    -
    Now
    Tokyo Medical and Dental University, Board Member, Director
  • 2019.04
    -
    Now
    Tokyo Medical and Dental University, Medical Hospital, Central Clinical Facilities, Intractable Disease Treatment, Director
  • 2019.08
    -
    Now
    Tokyo Medical and Dental University, Medical Hospital, Central Clinical Facilities, Intractable Disease Treatment, Director
  • 2021.04
    -
    Now
    Tokyo Medical and Dental University, Board Member, Vice President
  • 2021.04
    -
    Now
    Tokyo Medical and Dental University, -, Director
  • 2021.04
    -
    Now
    Tokyo Medical and Dental University, Institute of Global Affairs, Director
  • 2021.04
    -
    Now
    Tokyo Medical and Dental University, Board Member, Deputy Director
  • 2016.04
    -
    2017.03
    Tokyo Medical and Dental University, Institute of Education, Director
  • 2017.04
    -
    2020.03
    Tokyo Medical and Dental University, Board Member, Deputy Director
  • 2017.04
    -
    2020.03
    Tokyo Medical and Dental University, Board Member, Director
  • 2018.09
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Pediatrics and Developmental Biology, Professor
  • 2020.04
    -
    2021.03
    Tokyo Medical and Dental University, Board Member, Vice President
  • 2020.04
    -
    2021.03
    Tokyo Medical and Dental University, Board Member, Deputy Director

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Academic Society Affiliations 【 display / non-display

  • Japan Pediatric Society

  • Japanese Sosiety of Hematology

  • Japanese Society of Hematopoietic Stem Cell Transplantation

  • Japanese Society of Regenerative Medicine

  • Japanese Society for pediatric Infectious Disease

  • The Japanese Society of Clinical Immunology

  • The Japanese Society of Pediatric Hematology/Oncology

  • Japanese Society for Immunodeficiency and Autoinflammatory Diseases

  • The Japanese Medical Science Federation

  • Physicians' Education Council of Japan for Clinical Trials

  • Japanese Society of Immunotherapy for Hematological Disorders

  • Meeting for Immunodeficiency in Kanto-Koetsu Area

  • ISSCR

  • Molecular Biology Society of Japan

  • Japanese Society of Immunology

  • Japanese Society of Allergology

  • Japanese Cancer Association

  • Japanese Association for research on Epstein-Barr virus and related diseases

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Academic Activity 【 display / non-display

  • 2006.04
    -
    Now
    Japanese Society of Pediatrics(Councilor)
  • 2008.10
    -
    Now
    Japanese Society for Pediatric Infectious Diseases (Councilor)

Research Areas 【 display / non-display

  • Genome biology

  • Immunology

  • Embryonic medicine and pediatrics

Qualification Acquired 【 display / non-display

  • Doctor

  • Japanese Society of Pediatrics (Board certified physician)

 

Research Theme 【 display / non-display

  • Initiative on Rare and Undiagnosed Disease(IRUD), 2018.04 - 2024.03

Published Papers & Misc 【 display / non-display

  1. Masatoshi Takagi, Chitose Ogawa, Tomoko Iehara, Yuki Aoki-Nogami, Eri Ishibashi, Minoru Imai, Toshimi Kimura, Masashi Nagata, Masato Yasuhara, Mitsuko Masutani, Kenichi Yoshimura, Daisuke Tomizawa, Atsushi Ogawa, Kan Yonemori, Aoi Morishita, Satoshi Miyamoto, Junko Takita, Tetsuro Kihara, Kiyoshi Nobori, Kazuhisa Hasebe, Fuyuki Miya, Sadakatsu Ikeda, Yoko Shioda, Kimikazu Matsumoto, Junya Fujimura, Shuki Mizutani, Tomohiro Morio, Hajime Hosoi, Ryuji Koike. First phase 1 clinical study of olaparib in pediatric patients with refractory solid tumors. Cancer. 2022.08; 128 (15): 2949-2957. ( PubMed, DOI )

  2. Qian Zhang, Daniela Matuozzo, Jérémie Le Pen, Danyel Lee, Leen Moens, Takaki Asano, Jonathan Bohlen, Zhiyong Liu, Marcela Moncada-Velez, Yasemin Kendir-Demirkol, Huie Jing, Lucy Bizien, Astrid Marchal, Hassan Abolhassani, Selket Delafontaine, Giorgia Bucciol, , Gulsum Ical Bayhan, Sevgi Keles, Ayca Kiykim, Selda Hancerli, Filomeen Haerynck, Benoit Florkin, Nevin Hatipoglu, Tayfun Ozcelik, Guillaume Morelle, Mayana Zatz, Lisa F P Ng, David Chien Lye, Barnaby Edward Young, Yee-Sin Leo, Clifton L Dalgard, Richard P Lifton, Laurent Renia, Isabelle Meyts, Emmanuelle Jouanguy, Lennart Hammarström, Qiang Pan-Hammarström, Bertrand Boisson, Paul Bastard, Helen C Su, Stéphanie Boisson-Dupuis, Laurent Abel, Charles M Rice, Shen-Ying Zhang, Aurélie Cobat, Jean-Laurent Casanova. Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia. J Exp Med. 2022.08; 219 (8): ( PubMed, DOI )

  3. Akira Nishimura, Satoshi Miyamoto, Kohsuke Imai, Tomohiro Morio. Conditioning regimens for inborn errors of immunity: current perspectives and future strategies. Int J Hematol. 2022.07; 116 (1): 7-15. ( PubMed, DOI )

  4. Tessa Mollie Campbell, Zhiyong Liu, Qian Zhang, Marcela Moncada-Velez, Laura E Covill, Peng Zhang, Ilad Alavi Darazam, Paul Bastard, Lucy Bizien, Giorgia Bucciol, Sara Lind Enoksson, Emmanuelle Jouanguy, Şemsi Nur Karabela, Taushif Khan, Yasemin Kendir-Demirkol, Andres Augusto Arias, Davood Mansouri, Per Marits, Nico Marr, Isabelle Migeotte, Leen Moens, Tayfun Ozcelik, Isabelle Pellier, Anton Sendel, Mohammad Shahrooei, C I Edvard Smith, Isabelle Vandernoot, Karen Willekens, , Peter Bergman, Laurent Abel, Aurélie Cobat, Jean-Laurent Casanova, Isabelle Meyts, Yenan T Bryceson. Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency. J Exp Med. 2022.07; 219 (7): ( PubMed, DOI )

  5. Toshihiro Yamaguchi, Masao Iwagami, Chieko Ishiguro, Daisuke Fujii, Norihisa Yamamoto, Manabu Narisawa, Takashi Tsuboi, Hikari Umeda, Natsumi Kinoshita, Toyotaka Iguchi, Tatsuya Noda, Shinya Tsuruta, Akira Oka, Tomohiro Morio, Kiyohito Nakai, Shuichiro Hayashi. Safety monitoring of COVID-19 vaccines in Japan Lancet Reg Health West Pac. 2022.06; 23 100442. ( PubMed, DOI )

  6. Shohei Eto, Yoko Nukui, Miyuki Tsumura, Yu Nakagama, Kenichi Kashimada, Yoko Mizoguchi, Takanori Utsumi, Maki Taniguchi, Fumiaki Sakura, Kosuke Noma, Yusuke Yoshida, Shinichiro Ohshimo, Shintaro Nagashima, Keisuke Okamoto, Akifumi Endo, Kohsuke Imai, Hirokazu Kanegane, Hidenori Ohnishi, Shintaro Hirata, Eiji Sugiyama, Nobuaki Shime, Masanori Ito, Hiroki Ohge, Yasutoshi Kido, Paul Bastard, Jean-Laurent Casanova, Osamu Ohara, Junko Tanaka, Tomohiro Morio, Satoshi Okada. Neutralizing Type I Interferon Autoantibodies in Japanese Patients with Severe COVID-19. J Clin Immunol. 2022.06; ( PubMed, DOI )

  7. Satoshi Miyamoto, Takasuke Ebato, Eri Watanabe, Tomohiro Morio, Hirokazu Kanegane. B-Cell Immune Reconstitution with Mixed Chimerism After Hematopoietic Cell Transplantation in a Patient with Severe Combined Immunodeficiency. J Clin Immunol. 2022.06; ( PubMed, DOI )

  8. Stuart G Tangye, Waleed Al-Herz, Aziz Bousfiha, Charlotte Cunningham-Rundles, Jose Luis Franco, Steven M Holland, Christoph Klein, Tomohiro Morio, Eric Oksenhendler, Capucine Picard, Anne Puel, Jennifer Puck, Mikko R J Seppänen, Raz Somech, Helen C Su, Kathleen E Sullivan, Troy R Torgerson, Isabelle Meyts. Human Inborn Errors of Immunity: 2022 Update on the Classification from the International Union of Immunological Societies Expert Committee. J Clin Immunol. 2022.06; ( PubMed, DOI )

  9. Tomoko Niwano, Tadashi Hosoya, Saori Kadowaki, Etsushi Toyofuku, Takuya Naruto, Masaki Shimizu, Hidenori Ohnishi, Ryuji Koike, Tomohiro Morio, Kohsuke Imai, Masayuki Yoshida, Shinsuke Yasuda. An adult case of suspected A20 haploinsufficiency mimicking polyarteritis nodosa. Rheumatology (Oxford). 2022.05; ( PubMed, DOI )

  10. Shuya Kaneko, Masaki Shimizu, Asami Shimbo, Hitoshi Irabu, Susumu Yamazaki, Toru Kanamori, Tomohiro Udagawa, Tomohiro Morio, Masaaki Mori. A girl with hearing loss, dizziness, hypertension, and pyelonephritis with ureteral edema: Questions Pediatr Nephrol. 2022.05; ( PubMed, DOI )

  11. Shuya Kaneko, Masaki Shimizu, Asami Shimbo, Hitoshi Irabu, Susumu Yamazaki, Toru Kanamori, Tomohiro Udagawa, Tomohiro Morio, Masaaki Mori. A girl with hearing loss, dizziness, hypertension, and pyelonephritis with ureteral edema: Answers Pediatr Nephrol. 2022.05; ( PubMed, DOI )

  12. Yuki Ichimura, Risa Konishi, Miwako Shobo, Sae Inoue, Mari Okune, Akemi Maeda, Ryota Tanaka, Noriko Kubota, Isao Matsumoto, Akiko Ishii, Akira Tamaoka, Asami Shimbo, Masaaki Mori, Tomohiro Morio, Takayuki Kishi, Takako Miyamae, Jantima Tanboon, Michio Inoue, Ichizo Nishino, Manabu Fujimoto, Toshifumi Nomura, Naoko Okiyama. Reliability of antinuclear matrix protein 2 antibody assays in idiopathic inflammatory myopathies is dependent on target protein properties J Dermatol. 2022.04; 49 (4): 441-447. ( PubMed, DOI )

  13. Miyamoto S, Umeda K, Kurata M, Yanagimachi M, Iguchi A, Sasahara Y, Okada K, Koike T, Tanoshima R, Ishimura M, Yamada M, Sato M, Takahashi Y, Kajiwara M, Kawaguchi H, Inoue M, Hashii Y, Yabe H, Kato K, Atsuta Y, Imai K, Morio T.. Hematopoietic Cell Transplantation for Inborn Errors of Immunity Other than Severe Combined Immunodeficiency in Japan: Retrospective Analysis for 1985-2016 J Clin Immunol. 2022.04; 42 (3): 529-545. ( PubMed )

  14. Motoi Yamashita, Tomohiro Morio. AIOLOS Variants Causing Immunodeficiency in Human and Mice Front Immunol. 2022.04; 13 866582. ( PubMed, DOI )

  15. Yusuke Noguchi, Atsuko Taki, Izumi Honda, Manabu Sugie, Tsunanori Shidei, Kazuyuki Ito, Haruka Iwata, Akira Koyama, Kaoru Okazaki, Masatoshi Kondo, Chikako Morioka, Kenichi Kashimada, Tomohiro Morio. Transcriptome analysis of umbilical cord mesenchymal stem cells revealed fetal programming due to chorioamnionitis Sci Rep. 2022.04; 12 (1): 6537. ( PubMed, DOI )

  16. Petter Brodin, Giorgio Casari, Liam Townsend, Cliona O'Farrelly, Ivan Tancevski, Judith Löffler-Ragg, Trine H Mogensen, Jean Laurent Casanova, . Studying severe long COVID to understand post-infectious disorders beyond COVID-19 Nat Med. 2022.04; ( PubMed, DOI )

  17. Sho Hosaka, Takahiro Kido, Kazuo Imagawa, Hiroko Fukushima, Tomohiro Morio, Shigeaki Nonoyama, Hidetoshi Takada. Correction to: Vaccination for Patients with Inborn Errors of Immunity: A Nationwide Survey in Japan J Clin Immunol. 2022.04; ( PubMed, DOI )

  18. Yuki Ichimura, Risa Konishi, Miwako Shobo, Sae Inoue, Mari Okune, Akemi Maeda, Ryota Tanaka, Noriko Kubota, Isao Matsumoto, Akiko Ishii, Akira Tamaoka, Asami Shimbo, Masaaki Mori, Tomohiro Morio, Takayuki Kishi, Takako Miyamae, Jantima Tanboon, Michio Inoue, Ichizo Nishino, Manabu Fujimoto, Toshifumi Nomura, Naoko Okiyama. Anti-nuclear matrix protein 2 antibody-positive inflammatory myopathies represent extensive myositis without dermatomyositis-specific rash. Rheumatology (Oxford). 2022.03; 61 (3): 1222-1227. ( PubMed, DOI )

  19. Taku Ishii, Nobutoshi Nawa, Tomohiro Morio, Takeo Fujiwara. Association between nationwide introduction of public-access defibrillation and sudden cardiac death in Japan: An interrupted time-series analysis. Int J Cardiol. 2022.03; 351 100-106. ( PubMed, DOI )

  20. Qian Zhang, Paul Bastard, Aurélie Cobat, Jean-Laurent Casanova. Human genetic and immunological determinants of critical COVID-19 pneumonia. Nature. 2022.03; 603 (7902): 587-598. ( PubMed, DOI )

  21. Yuji Takahashi, Hidetoshi Date, Hideki Oi, Takeya Adachi, Noriaki Imanishi, En Kimura, Hotake Takizawa, Shinji Kosugi, Naomichi Matsumoto, Kenjiro Kosaki, Yoichi Matsubara, , Hidehiro Mizusawa. Six years' accomplishment of the Initiative on Rare and Undiagnosed Diseases: nationwide project in Japan to discover causes, mechanisms, and cures. J Hum Genet. 2022.03; ( PubMed, DOI )

  22. Shohei Eto, Yoko Nukui, Miyuki Tsumura, Yu Nakagama, Kenichi Kashimada, Yoko Mizoguchi, Takanori Utsumi, Maki Taniguchi, Fumiaki Sakura, Kosuke Noma, Yusuke Yoshida, Shinichiro Ohshimo, Shintaro Nagashima, Keisuke Okamoto, Akifumi Endo, Kohsuke Imai, Hirokazu Kanegane, Hidenori Ohnishi, Shintaro Hirata, Eiji Sugiyama, Nobuaki Shime, Masanori Ito, Hiroki Ohge, Yasutoshi Kido, Paul Bastard, Jean-Laurent Casanova, Junko Tanaka, Tomohiro Morio, Satoshi Okada. Neutralizing Type I Interferon Autoantibodies in Japanese Patients With Severe COVID-19. Res Sq. 2022.03; ( PubMed, DOI )

  23. Dan Tomomasa, Claire Booth, Jack J Bleesing, Takeshi Isoda, Chie Kobayashi, Kazutoshi Koike, Takeshi Taketani, Akihisa Sawada, Akihiro Tamura, Rebecca A Marsh, Tomohiro Morio, Andrew R Gennery, Hirokazu Kanegane. Preemptive hematopoietic cell transplantation for asymptomatic patients with X-linked lymphoproliferative syndrome type 1 Clin Immunol. 2022.03; 237 108993. ( PubMed, DOI )

  24. Jérémy Manry, Paul Bastard, Adrian Gervais, Tom Le Voyer, Jérémie Rosain, Quentin Philippot, Eleftherios Michailidis, Hans-Heinrich Hoffmann, Shohei Eto, Marina Garcia-Prat, Lucy Bizien, Alba Parra-Martínez, Rui Yang, Liis Haljasmägi, Mélanie Migaud, Karita Särekannu, Julia Maslovskaja, Nicolas de Prost, Yacine Tandjaoui-Lambiotte, Charles-Edouard Luyt, Blanca Amador-Borrero, Alexandre Gaudet, Julien Poissy, Pascal Morel, Pascale Richard, Fabrice Cognasse, Jesús Troya, Sophie Trouillet-Assant, Alexandre Belot, Kahina Saker, Pierre Garçon, Jacques G Rivière, Jean-Christophe Lagier, Stéphanie Gentile, Lindsey B Rosen, Elana Shaw, Tomohiro Morio, et al.. The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies. Proc Natl Acad Sci U S A. 2022.03; 119 (21): e2200413119. ( PubMed, DOI )

  25. David Egg, Ina Caroline Rump, Noriko Mitsuiki, Jessica Rojas-Restrepo, Maria-Elena Maccari, Charlotte Schwab, Annemarie Gabrysch, Klaus Warnatz, Sigune Goldacker, Virginia Patiño, Daniel Wolff, Satoshi Okada, Seiichi Hayakawa, Yoshiaki Shikama, Kenji Kanda, Kohsuke Imai, Manabu Sotomatsu, Makoto Kuwashima, Takahiro Kamiya, Tomohiro Morio, Kazuaki Matsumoto, Takeshi Mori, Yuri Yoshimoto, Ingunn Dybedal, Maria Kanariou, Zeynep Yesim Kucuk, Hugo Chapdelaine, Lenka Petruzelkova, Hanns-Martin Lorenz, Kathleen E Sullivan, Jennifer Heimall, Michel Moutschen, Jiri Litzman, Mike Recher, Michael H Albert, Fabian Hauck, Suranjith Seneviratne, Jana Pachlopnik Schmid, Antonios Kolios, Gary Unglik, Christian Klemann, Scott Snapper, Lisa Giulino-Roth, Michael Svaton, Craig D Platt, Sophie Hambleton, Olaf Neth, Geraldine Gosse, Steffen Reinsch, Dirk Holzinger, Yae-Jean Kim, Shahrzad Bakhtiar, Faranaz Atschekzei, Reinhold Schmidt, Georgios Sogkas, Shanmuganathan Chandrakasan, William Rae, Beata Derfalvi, Hanne Vibeke Marquart, Ahmet Ozen, Ayca Kiykim, Elif Karakoc-Aydiner, Pavlína Králíčková, Godelieve de Bree, Dimitra Kiritsi, Markus G Seidel, Robin Kobbe, Jennifer Dantzer, Laia Alsina, Thais Armangue, Vassilios Lougaris, Philipp Agyeman, Sofia Nyström, David Buchbinder, Peter D Arkwright, Bodo Grimbacher. Therapeutic options for CTLA-4 Insufficiency J Allergy Clin Immunol. 2022.02; 149 (2): 736-746. ( PubMed, DOI )

  26. Dan Tomomasa, Kay Tanita, Seishi Higashi, Yuri Tasaka, Takashi Shimamura, Urara Sakurai, Tomoyo Matsubara, Satoshi Okada, Tomohiro Morio, Hirokazu Kanegane. Early diagnosis of partial interferon-γ receptor 1 deficiency prevents the development of Bacille de Calmette et Guérin osteomyelitis Clin Immunol. 2022.02; 235 108933. ( PubMed, DOI )

  27. Kay Tanita, Yoshiki Kawamura, Hiroki Miura, Noriko Mitsuiki, Takahiro Tomoda, Kento Inoue, Akihiro Iguchi, Masafumi Yamada, Taro Yoshida, Hideki Muramatsu, Norimasa Tada, Toshihiro Matsui, Motohiro Kato, Katsuhide Eguchi, Masataka Ishimura, Shouichi Ohga, Kohsuke Imai, Tomohiro Morio, Tetsushi Yoshikawa, Hirokazu Kanegane. Case Report: Rotavirus Vaccination and Severe Combined Immunodeficiency in Japan. Front Immunol. 2022.02; 13 786375. ( PubMed, DOI )

  28. Ryuichi Nakagawa, Kei Takasawa, Maki Gau, Atsumi Tsuji-Hosokawa, Hideya Kawaji, Yasuhiro Murakawa, Shuji Takada, Masashi Mikami, Satoshi Narumi, Maki Fukami, Rajini Sreenivasan, Tetsuo Maruyama, Elena Tucker, Liang Zhao, Josephine Bowles, Andrew Sinclair, Peter Koopman, Yoshihide Hayashizaki, Tomohiro Morio, Kenichi Kashimada. Two ovarian candidate enhancers, identified by time series enhancer RNA analyses, harbor rare genetic variations identified in ovarian insufficiency. Hum Mol Genet. 2022.02; ( PubMed, DOI )

  29. Teppei Ohkawa, Akira Nishimura, Kenjiro Kosaki, Yuki Aoki-Nogami, Daisuke Tomizawa, Kenichi Kashimada, Tomohiro Morio, Motohiro Kato, Shuki Mizutani, Masatoshi Takagi. PAX3/7-FOXO1 fusion-negative alveolar rhabdomyosarcoma in Schuurs-Hoeijmakers syndrome. J Hum Genet. 2022.01; 67 (1): 51-54. ( PubMed, DOI )

  30. Sho Hosaka, Takahiro Kido, Kazuo Imagawa, Hiroko Fukushima, Tomohiro Morio, Shigeaki Nonoyama, Hidetoshi Takada. Vaccination for Patients with Inborn Errors of Immunity: a Nationwide Survey in Japan J Clin Immunol. 2022.01; 43 (1): 183-194. ( PubMed, DOI )

  31. Manry J, Bastard P, Gervais A, Voyer TL, Rosain J, Philippot Q, Michailidis E, Hoffmann HH, Eto S, Garcia-Prat M, Bizien L, Parra-Martínez A, Yang R, Haljasmägi L, Migaud M, Särekannu K, Maslovskaja J, de Prost N, Tandjaoui-Lambiotte Y, Luyt CE, Amador-Borrero B, Gaudet A, Poissy J, Morel P, Richard P, Cognasse F, Troya J, Trouillet-Assant S, Belot A, Saker K, Garçon P, Rivière JG, Lagier JC, Gentile S, Rosen L, Shaw E, Morio T, Tanaka J, Dalmau D, Tharaux PL, Sene D, Stepanian A, Mégarbane B, Triantafyllia V, Fekkar A, Heath J, Franco J, Anaya JM, Solé-Violán J, Imberti L, Biondi A, Bonfanti P, Castagnoli R, Delmonte O, Zhang Y, Snow A, Holland S, Biggs C, Moncada-Vélez M, Arias A, Lorenzo L, Boucherit S, Anglicheau D, Planas A, Haerynck F, Duvlis S, Nussbaum R, Ozcelik T, Keles S, Bousfiha A, Bakkouri JE, Ramirez-Santana C, Paul S, Pan-Hammarstrom Q, Hammarstrom L, Dupont A, Kurolap A, Metz C, Aiuti A, Casari G, Lampasona V, Ciceri F, Barreiros L, Dominguez-Garrido E, Vidigal M, Zatz M, van de Beek D, Sahanic S, Tancevski I, Stepanovskyy Y, Boyarchuk O, Nukui Y, Tsumura M, Vidaur L, Tangye S, Burrel S, Duffy D, Quintana-Murci L, Klocperk A, Kann N, Shcherbina A, Lau YL, Leung D, Coulongeat M, Marlet J, Koning R, Reyes L, Chauvineau-Grenier A, Venet F, Monneret G, Nussenzweig M, Arrestier R, Boudhabhay I, Baris-Feldman H, Hagin D, Wauters J, Meyts I, Dyer A, Kennelly S, Bourke N, Halwani R, Sharif-Askari F, Dorgham K, Sallette J, Mehlal-Sedkaoui S, AlKhater S, Rigo-Bonnin R, Morandeira F, Roussel L, Vinh D, Erikstrup C, Condino-Neto A, Prando C, Bondarenko A, Spaan A, Gilardin L, Fellay J, Lyonnet S, Bilguvar K, Lifton R, Mane S, Anderson M, Boisson B, Béziat V, Zhang SY, Andreakos E, Hermine O, Pujol A, Peterson P, Mogensen TH, Rowen L, Mond J, Debette S, deLamballerie X, Burdet C, Bouadma L, Zins M, Soler-Palacin P, Colobran R, Gorochov G, Solanich X, Susen S, Martinez-Picado J, Raoult D, Vasse M, Gregersen P, Rodríguez-Gallego C, Piemonti L, Notarangelo L, Su H, Kisand K, Okada S, Puel A, Jouanguy E, Rice C, Tiberghien P, Zhang Q, Casanova JL, Abel L, Cobat A.. The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies. Res Sq. 2022.01; ( PubMed, DOI )

  32. Yohei Yamaguchi, Kei Takasawa, Hitoshi Irabu, Kanako Hiratoko, Yosuke Ichigi, Ko Hirata, Yumie Tamura, Miki Murakoshi, Motoi Yamashita, Hisae Nakatani, Masuhiro Shimoda, Taku Ishii, Tomohiro Udagawa, Masaki Shimizu, Hirokazu Kanegane, Tomohiro Morio. Infliximab treatment for refractory COVID-19-associated multisystem inflammatory syndrome in a Japanese child J Infect Chemother. 2022.01; ( PubMed, DOI )

  33. Dan Tomomasa, Takeshi Sato, Tomonobu Hasegawa, Tomohiro Morio, Hirokazu Kanegane. Cartilage-hair hypoplasia with T-cell dysfunction. Pediatr Int. 2022.01; 64 (1): e15080. ( PubMed, DOI )

  34. Etsushi Toyofuku, Kozue Takeshita, Hidenori Ohnishi, Yuko Kiridoshi, Hiroaki Masuoka, Tomonori Kadowaki, Ryuta Nishikomori, Kenichi Nishimura, Chie Kobayashi, Takasuke Ebato, Tomonari Shigemura, Yuzaburo Inoue, Wataru Suda, Masahira Hattori, Tomohiro Morio, Kenya Honda, Hirokazu Kanegane. Dysregulation of the Intestinal Microbiome in Patients With Haploinsufficiency of A20. Front Cell Infect Microbiol. 2022.01; 11 787667. ( PubMed, DOI )

  35. Yusuke Noguchi, Tsunanori Shidei, Chikako Morioka, Kenichi Kashimada, Tomohiro Morio. A suspected case of heterotopic glia in an MM-twin discordant for anencephaly Pediatr Int. 2022.01; 64 (1): e15027. ( PubMed, DOI )

  36. Masaki Shimizu, Asami Shimbo, Masatoshi Takagi, Katsuhide Eguchi, Masataka Ishimura, Junichi Sugita, Tomohiro Morio, Hirokazu Kanegane. Successful treatment of joint and fascial chronic graft-versus-host disease with baricitinib. Rheumatology (Oxford). 2021.12; 61 (1): e1-e3. ( PubMed, DOI )

  37. Tsubasa Okano, Akira Nishimura, Kento Inoue, Takuya Naruto, Shown Tokoro, Takahiro Tomoda, Takahiro Kamiya, Asami Simbo, Yuko Akutsu, Keisuke Okamoto, Tzuwen Yeh, Takeshi Isoda, Masakatsu Yanagimachi, Michiko Kajiwara, Kohsuke Imai, Hirokazu Kanegane, Masaaki Mori, Tomohiro Morio, Masatoshi Takagi. Somatic mutation in RUNX1 underlies mucocutaneus inflammatory manifestations. Rheumatology (Oxford). 2021.12; 60 (12): e429-e431. ( PubMed, DOI )

  38. Hye Sun Kuehn, Jingjie Chang, Motoi Yamashita, Julie E Niemela, Chengcheng Zou, Kazuki Okuyama, Junji Harada, Jennifer L Stoddard, Cristiane J Nunes-Santos, Brigette Boast, Ryan M Baxter, Elena W Y Hsieh, Mary Garofalo, Thomas A Fleisher, Tomohiro Morio, Ichiro Taniuchi, Cullen M Dutmer, Sergio D Rosenzweig. T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients. J Exp Med. 2021.12; 218 (12): ( PubMed, DOI )

  39. Dan Tomomasa, Takeshi Isoda, Noriko Mitsuiki, Motoi Yamashita, Aoi Morishita, Takahiro Tomoda, Tsubasa Okano, Akifumi Endo, Takahiro Kamiya, Masakatsu Yanagimachi, Kohsuke Imai, Hirokazu Kanegane, Masatoshi Takagi, Tomohiro Morio. Successful ruxolitinib administration for a patient with steroid-refractory idiopathic pneumonia syndrome following hematopoietic stem cell transplantation: A case report and literature review. Clin Case Rep. 2021.12; 9 (12): e05242. ( PubMed, DOI )

  40. Satoshi Miyamoto, Katsutsugu Umeda, Mio Kurata, Akira Nishimura, Masakatsu Yanagimachi, Masataka Ishimura, Maho Sato, Tomonari Shigemura, Motohiro Kato, Yoji Sasahara, Akihiro Iguchi, Takashi Koike, Yoshiyuki Takahashi, Michiko Kajiwara, Masami Inoue, Yoshiko Hashii, Hiromasa Yabe, Koji Kato, Yoshiko Atsuta, Kohsuke Imai, Tomohiro Morio. Hematopoietic Cell Transplantation for Severe Combined Immunodeficiency Patients: a Japanese Retrospective Study. J Clin Immunol. 2021.11; 41 (8): 1865-1877. ( PubMed, DOI )

  41. Miwako Toyohara, Yuko Kajiho, Etsushi Toyofuku, Chie Takahashi, Keiho Owada, Shoichiro Kanda, Yutaka Harita, Hidenori Ohnishi, Taizo Wada, Kohsuke Imai, Hirokazu Kanegane, Tomohiro Morio, Akira Oka. An infant with X-linked anhidrotic ectodermal dysplasia with immunodeficiency presenting with Pneumocystis pneumonia: A case report Clin Case Rep. 2021.11; 9 (11): e05093. ( PubMed, DOI )

  42. Kei Takasawa, Hirokazu Kanegane, Kenichi Kashimada, Tomohiro Morio. Endocrinopathies in Inborn Errors of Immunity Front Immunol. 2021.11; 12 786241. ( PubMed, DOI )

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  129. Akihiro Hoshino, Xi Yang, Kay Tanita, Kenichi Yoshida, Toshiaki Ono, Naonori Nishida, Yusuke Okuno, Takeyuki Kanzaki, Kumiko Goi, Hisanori Fujino, Koichi Ohshima, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seishi Ogawa, Seiji Kojima, Tomohiro Morio, Hirokazu Kanegane. Modification of cellular and humoral immunity by somatically reverted T cells in X-linked lymphoproliferative syndrome type 1. J. Allergy Clin. Immunol.. 2018.10; 413 (1): 421-424. ( PubMed, DOI )

  130. Chelisa Cardinez, Bahar Miraghazadeh, Kay Tanita, Elizabeth da Silva, Akihiro Hoshino, Satoshi Okada, Rochna Chand, Takaki Asano, Miyuki Tsumura, Kenichi Yoshida, Hidenori Ohnishi, Zenichiro Kato, Masahide Yamazaki, Yusuke Okuno, Satoru Miyano, Seiji Kojima, Seishi Ogawa, T Daniel Andrews, Matthew A Field, Gaetan Burgio, Tomohiro Morio, Carola G Vinuesa, Hirokazu Kanegane, Matthew C Cook. Gain-of-function IKBKB mutation causes human combined immune deficiency. J. Exp. Med.. 2018.10; 215 (11): 2715-2724. ( PubMed, DOI )

  131. Kashimada A, Hasegawa S, Nomura T, Shiraku H, Moriyama K, Suzuki T, Nakajima K, Mizuno T, Imai K, Sugawara Y, Morio T, Kumada S, Takagi M. Genetic analysis of undiagnosed ataxia-telangiectasia-like disorders. Brain & development. 2018.10; 41 (2): 150-157. ( PubMed, DOI )

  132. Atsumi Tsuji-Hosokawa, Kenichi Kashimada, Tomoko Kato, Yuya Ogawa, Risa Nomura, Kei Takasawa, Rowena Lavery, Andrea Coschiera, David Schlessinger, Vincent R Harley, Shuji Takada, Tomohiro Morio. Peptidyl arginine deiminase 2 (Padi2) is expressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development. Sci Rep. 2018.09; 8 (1): 13263. ( PubMed, DOI )

  133. Yuriko Nishiyama-Fujita, A I Kawana-Tachikawa, Toshiaki Ono, Yukie Tanaka, Takafumi Kato, Helen E Heslop, Tomohiro Morio, Satoshi Takahashi. Generation of multivirus-specific T cells by a single stimulation of peripheral blood mononuclear cells with a peptide mixture using serum-free medium. Cytotherapy. 2018.08; 20 (9): 1182-1190. ( PubMed, DOI )

  134. Akihiro Hoshino, Kay Tanita, Kenji Kanda, Ken-Ichi Imadome, Yoshiaki Shikama, Takahiro Yasumi, Kohsuke Imai, Masatoshi Takagi, Tomohiro Morio, Hirokazu Kanegane. High frequencies of asymptomatic Epstein-Barr virus viremia in affected and unaffected individuals with CTLA4 mutations. Clin. Immunol.. 2018.07; 195 45-48. ( PubMed, DOI )

  135. Kenji Kubara, Kazuto Yamazaki, Yasuharu Ishihara, Takuya Naruto, Huan-Ting Lin, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Masashi Ito, Kappei Tsukahara, Tomohiro Morio, Masatoshi Takagi, Makoto Otsu. Status of KRAS in iPSCs Impacts upon Self-Renewal and Differentiation Propensity. Stem Cell Reports. 2018.06; 11 (2): 380-394. ( PubMed, DOI )

  136. Noguchi Y, Tomizawa D, Hiroki H, Miyamoto S, Tezuka M, Miyawaki R, Tanaka-Kubota M, Okano T, Kobayashi C, Mitsuiki N, Aoki Y, Imai K, Kajiwara M, Kanegane H, Morio T, Takagi M.. Hematopoietic cell transplantation for myeloid/NK cell precursor acute leukemia in second remission. Clin Case Rep. 2018.06; 6 (6): 1023-1028. ( PubMed, DOI )

  137. Asami Shimbo, Kei Takasawa, Masato Nishioka, Tomohiro Morio, Masayuki Shimohira. Complications of Listeria meningitis in two immunocompetent children. Pediatr Int. 2018.05; 60 (5): 491-492. ( PubMed, DOI )

  138. Yoshinori Kawabe, Takahiro Morio, Yoshimasa Tanaka, Pauline Schaap. Glycogen synthase kinase 3 promotes multicellular development over unicellular encystation in encysting Dictyostelia. Evodevo. 2018.05; 9 12. ( PubMed, DOI )

  139. Okano T, Imai K, Tsujita Y, Mitsuiki N, Yoshida K, Kamae C, Honma K, Mitsui-Sekinaka K, Sekinaka Y, Kato T, Hanabusa K, Endo E, Takashima T, Hiroki H, Yeh TW, Tanaka K, Nagahori M, Tsuge I, Bando Y, Iwasaki F, Shikama Y, Inoue M, Kimoto T, Moriguchi N, Yuza Y, Kaneko T, Suzuki K, Matsubara T, Maruo Y, Kunitsu T, Waragai T, Sano H, Hashimoto Y, Tasaki K, Suzuki O, Shirakawa T, Kato M, Uchiyama T, Ishimura M, Tauchi T, Yagasaki H, Jou ST, Yu HH, Kanegane H, Kracker S, Durandy A, Kojima D, Muramatsu H, Wada T, Inoue Y, Takada H, Kojima S, Ogawa S, Ohara O, Nonoyama S, Morio T.. Hematopoietic Stem Cell Transplantation for Progressive Combined Immunodeficiency and Lymphoproliferation in Activated PI3K <delta> Syndrome Type 1. J. Allergy Clin. Immunol.. 2018.05; 143 (1): 266-275. ( PubMed, DOI )

  140. Ono S, Nakayama M, Kanegane H, Hoshino A, Shimodera S, Shibata H, Fujino H, Fujino T, Yunomae Y, Okano T, Yamashita M, Yasumi T, Izawa K, Takagi M, Imai K, Zhang K, Marsh R, Picard C, Latour S, Ohara O, Morio T.. Comprehensive molecular diagnosis of Epstein-Barr virus-associated lymphoproliferative diseases using next-generation sequencing. Int. J. Hematol.. 2018.05; 108 (3): 319-328. ( PubMed, DOI )

  141. Asano T, Okada S, Tsumura M, Yeh TW, Mitsui-Sekinaka K, Tsujita Y, Ichinose Y, Shimada A, Hashimoto K, Wada T, Imai K, Ohara O, Morio T, Nonoyama S, Kobayashi M.. Enhanced AKT Phosphorylation of Circulating B Cells in Patients With Activated PI3Kδ Syndrome Front Immunol. 2018.04; 9 568. ( PubMed, DOI )

  142. Okano T, Tsujita Y, Kanegane H, Mitsui-Sekinaka K, Tanita K, Miyamoto S, Yeh TW, Yamashita M, Terada N, Ogura Y, Takagi M, Imai K, Nonoyama S, Morio T.. Droplet Digital PCR-Based Chimerism Analysis for Primary Immunodeficiency Diseases. J. Clin. Immunol.. 2018.04; 38 (3): 300-306. ( PubMed, DOI )

  143. Akihiro Hoshino, Takehiro Takashima, Kenichi Yoshida, Akira Morimoto, Yuta Kawahara, Tzu-Wen Yeh, Tsubasa Okano, Motoi Yamashita, Noriko Mitsuiki, Kohsuke Imai, Takashi Sakatani, Atsuko Nakazawa, Yusuke Okuno, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seishi Ogawa, Seiji Kojima, Tomohiro Morio, Hirokazu Kanegane. Dysregulation of Epstein-Barr virus infection in hypomorphic ZAP70 mutation J. Infect. Dis.. 2018.04; 218 (5): 825-834. ( PubMed, DOI )

  144. Ryuichi Nakagawa, Atsumi Hosokawa-Tsuji, Yuki Aoki, Kei Takasawa, Mitsue Maru, Keisuke Nakajima, Akito Sutani, Yuichi Miyakawa, Daisuke Tomizawa, Kenichi Kashimada, Tomohiro Morio. Total body irradiation for hematopoietic stem cell transplantation during early childhood is associated with the risk for diabetes mellitus Endocrine. 2018.04; 61 (1): 76-82. ( PubMed, DOI )

  145. Rina Nishii, Takaya Moriyama, Laura J Janke, Wenjian Yang, Chase Suiter, Ting-Nien Lin, Lie Li, Kentaro Kihira, Hidemi Toyoda, Ute Hofmann, Matthias Schwab, Masatoshi Takagi, Tomohiro Morio, Atsushi Manabe, Shirley Kham, Nan Jiang, Karen R Rabin, Motohiro Kato, Katsuyoshi Koh, Allen Eng-Juh Yeoh, Hiroki Hori, Jun J Yang. Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and anti-leukemic efficacy. Blood. 2018.03; 131 (22): 2466-2474. ( PubMed, DOI )

  146. Yasuo Horikoshi, Katsutsugu Umeda, Kohsuke Imai, Hiromasa Yabe, Yoji Sasahara, Kenichiro Watanabe, Yukiyasu Ozawa, Yoshiko Hashii, Hidemitsu Kurosawa, Shigeaki Nonoyama, Tomohiro Morio. Allogeneic Hematopoietic Stem Cell Transplantation for Leukocyte Adhesion Deficiency. J. Pediatr. Hematol. Oncol.. 2018.03; 40 (2): 137-140. ( PubMed, DOI )

  147. Yuji Sugawara, Kohsuke Imai, Ayako Kashimada, Kengo Moriyama, Shimpei Baba, Ryuta Nishikomori, Mizuho Motegi, Yasuo Takeuchi, Tomohiro Morio. Autoinflammatory phenotypes in Aicardi-Goutières syndrome with interferon upregulation and serological autoimmune features. J. Allergy Clin. Immunol.. 2018.03; 141 (3): 1135-1138. ( PubMed, DOI )

  148. Yasuyoshi Ishiwata, Masashi Nagata, Kohta Tsuge, Hiromitsu Takahashi, Sayo Suzuki, Kohsuke Imai, Masatoshi Takagi, Hirokazu Kanegane, Tomohiro Morio, Masato Yasuhara. Population Pharmacokinetics of Intravenous Busulfan in Japanese Pediatric Patients With Primary Immunodeficiency Diseases. J Clin Pharmacol. 2018.03; 58 (3): 327-331. ( PubMed, DOI )

  149. Daniel Petersheim, Michel J Massaad, Saetbyul Lee, Alessia Scarselli, Caterina Cancrini, Kunihiko Moriya, Yoji Sasahara, Arjan C Lankester, Morna Dorsey, Daniela Di Giovanni, Liliana Bezrodnik, Hidenori Ohnishi, Ryuta Nishikomori, Kay Tanita, Hirokazu Kanegane, Tomohiro Morio, Erwin W Gelfand, Ashish Jain, Elizabeth Secord, Capucine Picard, Jean-Laurent Casanova, Michael H Albert, Troy R Torgerson, Raif S Geha. Mechanisms of genotype-phenotype correlation in autosomal dominant anhidrotic ectodermal dysplasia with immune deficiency. J. Allergy Clin. Immunol.. 2018.03; 141 (3): 1060-1073.e3. ( PubMed, DOI )

  150. Toshiaki Ono, Yuriko Fujita, Tetsuro Matano, Satoshi Takahashi, Tomohiro Morio, Ai Kawana-Tachikawa. Characterization of in vitro expanded virus-specific T cells toward adoptive immunotherapy against virus infection Jpn. J. Infect. Dis.. 2018.02; 71 (2): 122-128. ( PubMed, DOI )

  151. Ayako Kashimada, Setsuko Hasegawa, Takeo Isagai, Tsuyoshi Uchiyama, Muneaki Matsuo, Motoharu Kawai, Masahide Goto, Tomohiro Morio, Yukiko K Hayashi, Masatoshi Takagi. Targeting the enhanced ER stress response in Marinesco-Sjögren syndrome J. Neurol. Sci.. 2018.02; 385 49-56. ( PubMed, DOI )

  152. Ryuichi Nakagawa, Kei Takasawa, Tzu-Wen Yeh, Kohsuke Imai, Kenichi Kashimada, Tomohiro Morio. Type 1 Diabetes Mellitus Associated with Activated Phosphoinositide-3-kinase Delta Syndrome, Type 2. J Diabetes. 2018.02; 10 (5): 421-422. ( PubMed, DOI )

  153. Masatoshi Takagi, Akihiro Hoshino, Kenichi Yoshida, Hiroo Ueno, Kohsuke Imai, Jinhua Piao, Hirokazu Kanegane, Motoi Yamashita, Tsubasa Okano, Hideki Muramatsu, Yusuke Okuno, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seishi Ogawa, Yasuhide Hayashi, Seiji Kojima, Tomohiro Morio. Genetic heterogeneity of uncharacterized childhood autoimmune diseases with lymphoproliferation. Pediatr Blood Cancer. 2018.02; 65 (2): ( PubMed, DOI )

  154. Takasawa Kei, Nakagawa Ryuichi, Takishima Shigeru, Moriyama Kengo, Watanabe Ken, Kiyohara Koji, Hasegawa Takeshi, Shimohira Masahiro, Kashimada Kenichi, Shimizu Norio, Morio Tomohiro. 迅速かつ網羅的なウイルス検査システムによって診断した日本人小児の急性脳炎/脳症の原因と臨床症状の違い(Cause of acute encephalitis/encephalopathy in Japanese children diagnosed by a rapid and comprehensive virological detection system and differences in their clinical presentations) Brain & Development. 2018.02; 40 (2): 107-115. ( ichushi )

  155. Kei Takasawa, Maki Igarashi, Makoto Ono, Akira Takemoto, Shuji Takada, Atsuyuki Yamataka, Tsutomu Ogata, Tomohiro Morio, Maki Fukami, Kenichi Kashimada. Phenotypic Variation in 46,XX Disorders of Sex Development due to the NR5A1 p.R92W Variant: A Sibling Case Report and Literature Review Sex Dev. 2018.01; 11 (5-6): 284-288. ( PubMed, DOI )

  156. Toshihiro Matsui, Takumi Matsumoto, Fumio Hirano, Fumika Tokunaga, Keisuke Okamoto, Shigeto Tohma, Tomohiro Morio, Hitoshi Kohsaka, Masaaki Mori. Survey of the awareness of adult rheumatologists regarding transitional care for patients with juvenile idiopathic arthritis in Japan Mod Rheumatol. 2018.01; 28 (6): 981-985. ( PubMed, DOI )

  157. Matsuda Nozomi, Taki Atsuko, Tsuji Atsumi, Nakajima Keisuke, Takasawa Kei, Morioka Chikako, Minosaki Yoshihiro, Oku Kikuko, Kashimada Kenichi, Morio Tomohiro. 在胎週数の割に小さく産まれた超低出生体重児における3歳時点での成長と発達に影響を与える周産期要因(Perinatal factors affecting growth and development at age 3 years in extremely low birth weight infants born small for gestational age) Clinical Pediatric Endocrinology. 2018.01; 27 (1): 31-38. ( ichushi )

  158. Akihiro Tamura, Suguru Uemura, Nobuyuki Yamamoto, Atsuro Saito, Aiko Kozaki, Kenji Kishimoto, Toshiaki Ishida, Daiichiro Hasegawa, Haruka Hiroki, Tsubasa Okano, Kohsuke Imai, Tomohiro Morio, Hirokazu Kanegane, Yoshiyuki Kosaka. Hematopoietic cell transplantation for asymptomatic X-linked lymphoproliferative syndrome type 1. Allergy Asthma Clin Immunol. 2018; 14 82. ( PubMed, DOI )

  159. Kazuo Takayama, Naoki Akita, Natsumi Mimura, Rina Akahira, Yukimasa Taniguchi, Makoto Ikeda, Fuminori Sakurai, Osamu Ohara, Tomohiro Morio, Kiyotoshi Sekiguchi, Hiroyuki Mizuguchi. Generation of safe and therapeutically effective human induced pluripotent stem cell-derived hepatocyte-like cells for regenerative medicine Hepatol Commun. 2017.12; 1 (10): 1058-1069. ( PubMed, DOI )

  160. Tomonori Kadowaki, Hidenori Ohnishi, Norio Kawamoto, Tomohiro Hori, Kenichi Nishimura, Chie Kobayashi, Tomonari Shigemura, Shohei Ogata, Yuzaburo Inoue, Tomoki Kawai, Eitaro Hiejima, Masatoshi Takagi, Kohsuke Imai, Ryuta Nishikomori, Shuichi Ito, Toshio Heike, Osamu Ohara, Tomohiro Morio, Toshiyuki Fukao, Hirokazu Kanegane. Haploinsufficiency of A20 causes autoinflammatory and autoimmune disorders. J. Allergy Clin. Immunol.. 2017.12; 141 (4): 1485-1488. ( PubMed, DOI )

  161. Capucine Picard, H Bobby Gaspar, Waleed Al-Herz, Aziz Bousfiha, Jean-Laurent Casanova, Talal Chatila, Yanick J Crow, Charlotte Cunningham-Rundles, Amos Etzioni, Jose Luis Franco, Steven M Holland, Christoph Klein, Tomohiro Morio, Hans D Ochs, Eric Oksenhendler, Jennifer Puck, Mimi L K Tang, Stuart G Tangye, Troy R Torgerson, Kathleen E Sullivan. International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity. J. Clin. Immunol. 2017.12; 38 (1): 96-128. ( PubMed, DOI )

  162. Aziz Bousfiha, Leïla Jeddane, Capucine Picard, Fatima Ailal, H Bobby Gaspar, Waleed Al-Herz, Talal Chatila, Yanick J Crow, Charlotte Cunningham-Rundles, Amos Etzioni, Jose Luis Franco, Steven M Holland, Christoph Klein, Tomohiro Morio, Hans D Ochs, Eric Oksenhendler, Jennifer Puck, Mimi L K Tang, Stuart G Tangye, Troy R Torgerson, Jean-Laurent Casanova, Kathleen E Sullivan. The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies. J. Clin. Immunol. 2017.12; 38 (1): 129-143. ( PubMed, DOI )

  163. Risa Nomura, Kentaro Miyai, Gen Nishimura, Kenichi Kashimada, Tomohiro Morio. Myhre syndrome: Age-dependent progressive phenotype Pediatr Int. 2017.11; 59 (11): 1205-1206. ( PubMed, DOI )

  164. Mari Tanaka-Kubota, Koji Shinozaki, Satoshi Miyamoto, Masakatsu Yanagimachi, Tsubasa Okano, Noriko Mitsuiki, Masahiro Ueki, Masafumi Yamada, Kohsuke Imai, Masatoshi Takagi, Kazunaga Agematsu, Hirokazu Kanegane, Tomohiro Morio. Hematopoietic stem cell transplantation for pulmonary alveolar proteinosis associated with primary immunodeficiency disease. Int. J. Hematol.. 2017.11; 107 (5): 610-614. ( PubMed, DOI )

  165. Masatoshi Takagi, Misa Yoshida, Yoshino Nemoto, Hiroyuki Tamaichi, Rika Tsuchida, Masafumi Seki, Kumiko Uryu, Noriko Hoshino, Rina Nishii, Satoshi Miyamoto, Masahiro Saito, Toshiaki Shimizu, Ryoji Hanada, Hideo Kaneko, Toshiyuki Fukao, Takatoshi Koyama, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Yusuke Sato, Yoichi Fujii, Keisuke Kataoka, Yusuke Okuno, Kenichi Yoshida, Tomohiro Morio, Akira Oka, Miki Ohira, Yasuhide Hayashi, Akira Nakagawara, Seishi Ogawa, Shuki Mizutani, Junko Takita.. Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor. J. Natl. Cancer Inst.. 2017.11; 109 (11): ( PubMed, DOI )

  166. Miyamoto Satoshi, Takagi Masatoshi, Nishimura Akira, Tanaka Mari, Ono Shintaro, Ashiarai Miho, Mitsuiki Noriko, Hoshino Akihiro, Yanagimachi Masakatsu, Aoki Yuki, Tomizawa Daisuke, Imai Kohsuke, Kajiwara Michiko, Kanegane Hirokazu, Morio Tomohiro. A 7-year-old Girl who Maintains Complete Remission after Multiple Hematopoietic Cell Transplantation for Frequent Relapse of Infant Leukemia PEDIATRIC BLOOD & CANCER. 2017.11; 64 S92-S93.

  167. Tsubasa Okano, Takuro Nishikawa, Eri Watanabe, Takashi Watanabe, Takehiro Takashima, Tzu-Wen Yeh, Motoi Yamashita, Mari Tanaka-Kubota, Satoshi Miyamoto, Noriko Mitsuiki, Masatoshi Takagi, Yoshifumi Kawano, Yoshiki Mochizuki, Kohsuke Imai, Hirokazu Kanegane, Tomohiro Morio. Maternal T and B cell engraftment in two cases of X-linked severe combined immunodeficiency with IgG1 gammopathy. Clin. Immunol. 2017.10; 183 112-120. ( PubMed, DOI )

  168. Kei Takasawa, Ryuichi Nakagawa, Shigeru Takishima, Kengo Moriyama, Ken Watanabe, Koji Kiyohara, Takeshi Hasegawa, Masahiro Shimohira, Kenichi Kashimada, Norio Shimizu, Tomohiro Morio. Cause of acute encephalitis/encephalopathy in Japanese children diagnosed by a rapid and comprehensive virological detection system and differences in their clinical presentations. Brain Dev. 2017.10; 40 (2): 107-115. ( PubMed, DOI )

  169. Shimpei Baba, Ayumi Kobayashi, Haruna Yokoyama, Kengo Moriyama, Ayako Kashimada, Jun Oyama, Ayako Owada, Shoichi Oyama, Tomohiro Morio, Masatoshi Takagi. Slowly progressive leukodystrophy in an adolescent male with phosphoglycerate kinase deficiency. Brain Dev. 2017.10; 40 (2): 150-154. ( PubMed, DOI )

  170. Masayuki Nagasawa, Noriko Mitsuiki, Yuki Aoki, Toshiaki Ono, Takeshi Isoda, Kohsuke Imai, Masatoshi Takagi, Michiko Kajiwara, Hirokazu Kanegane, Tomohiro Morio. Effect of reduced-intensity conditioning and the risk of late-onset non-infectious pulmonary complications in pediatric patients. Eur. J. Haematol.. 2017.10; 99 (6): 525-531. ( PubMed, DOI )

  171. Hirokazu Kanegane, Akihiro Hoshino, Tsubasa Okano, Takahiro Yasumi, Taizo Wada, Hidetoshi Takada, Satoshi Okada, Motoi Yamashita, Tzu-Wen Yeh, Ryuta Nishikomori, Masatoshi Takagi, Kohsuke Imai, Hans D Ochs, Tomohiro Morio. Flow cytometry-based diagnosis of primary immunodeficiency diseases. Allergol Int. 2017.10; 67 (1): 43-54. ( PubMed, DOI )

  172. Jennifer W Leiding, Satoshi Okada, David Hagin, Mario Abinun, Anna Shcherbina, Dmitry N Balashov, Vy H D Kim, Adi Ovadia, Stephen L Guthery, Michael Pulsipher, Desa Lilic, Lisa A Devlin, Sharon Christie, Mark Depner, Sebastian Fuchs, Annet van Royen-Kerkhof, Caroline Lindemans, Aleksandra Petrovic, Kathleen E Sullivan, Nancy Bunin, Sara Sebnem Kilic, Fikret Arpaci, Oscar de la Calle-Martin, Laura Martinez-Martinez, Juan Carlos Aldave, Masao Kobayashi, Teppei Ohkawa, Kohsuke Imai, Akihiro Iguchi, Chaim M Roifman, Andrew R Gennery, Mary Slatter, Hans D Ochs, Tomohiro Morio, Troy R Torgerson, . Hematopoietic stem cell transplantation in patients with Gain of Function STAT1 Mutation. J. Allergy Clin. Immunol.. 2017.10; 141 (2): 704-717. ( PubMed, DOI )

  173. Atsumi Tsuji-Hosokawa, Kei Takasawa, Risa Nomura, Yuichi Miyakawa, Chikahiko Numakura, Atsushi Hijikata, Tsuyoshi Shirai, Yoshihiro Ogawa, Kenichi Kashimada, Tomohiro Morio. Molecular mechanisms of insulin resistance in 2 cases of primary insulin receptor defect-associated diseases. Pediatr Diabetes. 2017.10; 18 (8): 917-924. ( PubMed, DOI )

  174. Akira Endo, Miko Okamura, Shunsuke Yoshikawa, Yasuhiro Otomo, Tomohiro Morio. Multilateral Functional Alterations of Human Neutrophils in Sepsis: From the Point of Diagnosis to the Seventh Day. Shock. 2017.10; 48 (6): 629-637. ( PubMed, DOI )

  175. Tomohiro Morio. Recent advances in the study of immunodeficiency and DNA damage response. Int. J. Hematol. 2017.10; 106 (3): 357-365. ( PubMed, DOI )

  176. Johanna Schepp, Janet Chou, Andrea Skrabl-Baumgartner, Peter D Arkwright, Karin R Engelhardt, Sophie Hambleton, Tomohiro Morio, Ekkehard Röther, Klaus Warnatz, Raif Geha, Bodo Grimbacher. 14 Years after Discovery: Clinical Follow-up on 15 Patients with Inducible Co-Stimulator Deficiency. Front Immunol. 2017.08; 8 964. ( PubMed, DOI )

  177. Taizo Wada, Satoshi Miyamoto, Hiroyuki Okamoto, Yusuke Matsuda, Tomoko Toma, Kohsuke Imai, Masatoshi Takagi, Tomohiro Morio, Akihiro Yachie. Prolonged neutropenia due to antihuman neutrophil antigen 2 (CD177) antibody after bone marrow transplantation. Pediatr Blood Cancer. 2017.07; 64 (7): 26388. ( PubMed, DOI )

  178. Masayuki Nagasawa, Teppei Ohkawa, Masatoshi Takagi, Kohsuke Imai, Tomohiro Morio. A Stable Mixed Chimera After SCT with RIC in an Infant with IκBα Hypermorphic Mutation. J. Clin. Immunol.. 2017.07; 37 (5): 413-414. ( PubMed, DOI )

  179. Yujin Sekinaka, Noriko Mitsuiki, Kohsuke Imai, Miharu Yabe, Hiromasa Yabe, Kanako Mitsui-Sekinaka, Kenichi Honma, Masatoshi Takagi, Ayako Arai, Kenichi Yoshida, Yusuke Okuno, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Hideki Muramatsu, Seiji Kojima, Asuka Hira, Minoru Takata, Osamu Ohara, Seishi Ogawa, Tomohiro Morio, Shigeaki Nonoyama. Common Variable Immunodeficiency Caused by FANC Mutations. J. Clin. Immunol. 2017.07; 37 (5): 434-444. ( PubMed, DOI )

  180. Akihiro Hoshino, Satoshi Okada, Kenichi Yoshida, Naonori Nishida, Yusuke Okuno, Hiroo Ueno, Motoi Yamashita, Tsubasa Okano, Miyuki Tsumura, Shiho Nishimura, Sonoko Sakata, Masao Kobayashi, Haruna Nakamura, Junji Kamizono, Kanako Mitsui-Sekinaka, Takuya Ichimura, Shouichi Ohga, Yozo Nakazawa, Masatoshi Takagi, Kohsuke Imai, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seishi Ogawa, Seiji Kojima, Shigeaki Nonoyama, Tomohiro Morio, Hirokazu Kanegane. Abnormal hematopoiesis and autoimmunity in human subjects with germline IKZF1 mutations. J. Allergy Clin. Immunol.. 2017.07; 140 (1): 223-231. ( PubMed, DOI )

  181. Ayumi Kobayashi, Reiko Takasawa, Kei Takasawa, Masato Nishioka, Masahide Kaneko, Hiroshi Ono, Takanobu Maekawa, Tomohiro Morio, Masayuki Shimohira. An infant case of severe hypereosinophilia and systemic symptoms with multiple drug hypersensitivity and reactivation of cytomegalovirus and BK virus. Allergol Int. 2017.07; 66 (3): 479-481. ( PubMed, DOI )

  182. Ikumi Hori, Takanobu Otomo, Mitsuko Nakashima, Fuyuki Miya, Yutaka Negishi, Hideaki Shiraishi, Yutaka Nonoda, Shinichi Magara, Jun Tohyama, Nobuhiko Okamoto, Takeshi Kumagai, Konomi Shimoda, Yoshiya Yukitake, Daigo Kajikawa, Tomohiro Morio, Ayako Hattori, Motoo Nakagawa, Naoki Ando, Ichizo Nishino, Mitsuhiro Kato, Tatsuhiko Tsunoda, Hirotomo Saitsu, Yonehiro Kanemura, Mami Yamasaki, Kenjiro Kosaki, Naomichi Matsumoto, Tamotsu Yoshimori, Shinji Saitoh. Defects in autophagosome-lysosome fusion underlie Vici syndrome, a neurodevelopmental disorder with multisystem involvement. Sci Rep. 2017.06; 7 (1): 3552. ( PubMed, DOI )

  183. Takehiro Takashima, Miko Okamura, Tzu-Wen Yeh, Tsubasa Okano, Motoi Yamashita, Keisuke Tanaka, Akihiro Hoshino, Noriko Mitsuiki, Masatoshi Takagi, Eiichi Ishii, Kohsuke Imai, Hirokazu Kanegane, Tomohiro Morio. Multicolor Flow Cytometry for the Diagnosis of Primary Immunodeficiency Diseases. J. Clin. Immunol.. 2017.06; 37 (5): 486-495. ( PubMed, DOI )

  184. Masatoshi Takagi, Yasuyoshi Ishiwata, Yuki Aoki, Satoshi Miyamoto, Akihiro Hoshino, Kazuaki Matsumoto, Akira Nishimura, Mari Tanaka, Masakatsu Yanagimachi, Noriko Mitsuiki, Kohsuke Imai, Hirokazu Kanegane, Michiko Kajiwara, Kanako Takikawa, Tsukasa Mae, Osamu Tomita, Junya Fujimura, Masato Yasuhara, Daisuke Tomizawa, Shuki Mizutani, Tomohiro Morio. HLA haploidentical hematopoietic cell transplantation using clofarabine and busulfan for refractory pediatric hematological malignancy. Int. J. Hematol.. 2017.05; 105 (5): 686-691. ( PubMed, DOI )

  185. Haruna Yokoyama, Shimpei Baba, Jun Oyama, Kengo Moriyama, Tomohiro Morio. Early hypoperfusion on arterial spin labeling may be a diagnostic marker for acute encephalopathy with biphasic seizures and late reduced diffusion. Brain Dev.. 2017.05; 39 (8): 722. ( PubMed, DOI )

  186. Nienke J H van Os, Anne F M Jansen, Marcel van Deuren, Asgeir Haraldsson, Nieke T M van Driel, Amos Etzioni, Michiel van der Flier, Charlotte A Haaxma, Tomohiro Morio, Amit Rawat, Michiel H D Schoenaker, Annarosa Soresina, Alexander M R Taylor, Bart P C van de Warrenburg, Corry M R Weemaes, Nel Roeleveld, Michèl A A P Willemsen. Ataxia-telangiectasia: Immunodeficiency and survival. Clin. Immunol.. 2017.05; 178 45-55. ( PubMed, DOI )

  187. Shimpei Baba, Yuji Sugawara, Kengo Moriyama, Motoki Inaji, Taketoshi Maehara, Toshiyuki Yamamoto, Tomohiro Morio. Amelioration of intractable epilepsy by adjunct vagus nerve stimulation therapy in a girl with a CDKL5 mutation. Brain Dev. 2017.04; 39 (4): 341-344. ( PubMed, DOI )

  188. Hirokazu Kanegane, Kohsuke Imai, Tomohiro Morio. Severe combined immunodeficiency: From its discovery to the perspective. Nihon Rinsho Meneki Gakkai Kaishi. 2017.03; 40 (3): 145-154. ( PubMed, DOI )

  189. Chikako Morioka, Motohiro Komaki, Atsuko Taki, Izumi Honda, Naoki Yokoyama, Kengo Iwasaki, Sachiko Iseki, Tomohiro Morio, Ikuo Morita. Neuroprotective effects of human umbilical cord-derived mesenchymal stem cells on periventricular leukomalacia-like brain injury in neonatal rats. Inflamm Regen. 2017.01; 37 1. ( PubMed, DOI )

  190. Masatoshi Takagi, Shohei Ogata, Hiroo Ueno, Kenichi Yoshida, Tzuwen Yeh, Akihiro Hoshino, Jinhua Piao, Motoy Yamashita, Mai Nanya, Tsubasa Okano, Michiko Kajiwara, Hirokazu Kanegane, Hideki Muramatsu, Yusuke Okuno, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Yuki Bando, Motohiro Kato, Yasuhide Hayashi, Satoru Miyano, Kohsuke Imai, Seishi Ogawa, Seiji Kojima, Tomohiro Morio. Haploinsufficiency of TNFAIP3 (A20) by germline mutation is involved in autoimmune lymphoproliferative syndrome. J. Allergy Clin. Immunol.. 2017.01; 139 (6): 1914-1922. ( PubMed, DOI )

  191. Atsumi Tsuji-Hosokawa, Nozomi Matsuda, Kenji Kurosawa, Kenichi Kashimada, Tomohiro Morio. A Case of MECP2 Duplication Syndrome with Gonadotropin-Dependent Precocious Puberty. Horm Res Paediatr. 2017.01; 87 (4): 217-216. ( PubMed, DOI )

  192. Shintaro Ono, Tsubasa Okano, Akihiro Hoshino, Masakatsu Yanagimachi, Kazuko Hamamoto, Yozo Nakazawa, Toshihiko Imamura, Masaei Onuma, Hidetaka Niizuma, Yoji Sasahara, Hiroshi Tsujimoto, Taizo Wada, Reiko Kunisaki, Masatoshi Takagi, Kohsuke Imai, Tomohiro Morio, Hirokazu Kanegane. Hematopoietic Stem Cell Transplantation for XIAP Deficiency in Japan. J. Clin. Immunol.. 2017.01; 37 (1): 85-91. ( PubMed, DOI )

  193. Katsutsugu Umeda, Souichi Adachi, Shiro Tanaka, Mizuka Miki, Keiko Okada, Yoshiko Hashii, Masami Inoue, Yuko Cho, Katsuyoshi Koh, Hiroaki Goto, Ryosuke Kajiwara, Nobuyuki Hyakuna, Koji Kato, Tomohiro Morio, Hiromasa Yabe, . Comparison of second transplantation and donor lymphocyte infusion for donor mixed chimerism after allogeneic stem cell transplantation for nonmalignant diseases. Pediatr Blood Cancer. 2016.12; 63 (12): 2221-2229. ( PubMed, DOI )

  194. Yuki Tsujita, Kanako Mitsui-Sekinaka, Kohsuke Imai, Tzu-Wen Yeh, Noriko Mitsuiki, Takaki Asano, Hidenori Ohnishi, Zenichiro Kato, Yujin Sekinaka, Kiyotaka Zaha, Tamaki Kato, Tsubasa Okano, Takehiro Takashima, Kaoru Kobayashi, Mitsuaki Kimura, Tomoaki Kunitsu, Yoshihiro Maruo, Hirokazu Kanegane, Masatoshi Takagi, Kenichi Yoshida, Yusuke Okuno, Hideki Muramatsu, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seiji Kojima, Seishi Ogawa, Osamu Ohara, Satoshi Okada, Masao Kobayashi, Tomohiro Morio, Shigeaki Nonoyama. Phosphatase and tensin homolog (PTEN) mutation can cause activated phosphatidylinositol 3-kinase δ syndrome-like immunodeficiency. J. Allergy Clin. Immunol.. 2016.12; 138 (6): 1672-1680. ( PubMed, DOI )

  195. Akifumi Endo, Daisuke Tomizawa, Yuki Aoki, Tomohiro Morio, Shuki Mizutani, Masatoshi Takagi. EWSR1/ELF5 induces acute myeloid leukemia by inhibiting p53/p21 pathway. Cancer Sci.. 2016.12; 107 (12): 1745-1754. ( PubMed, DOI )

  196. Shigeru Takishima, Keisuke Nakajima, Risa Nomura, Atsumi Tsuji-Hosokawa, Nozomi Matsuda, Yohei Matsubara, Makoto Ono, Kentaro Miyai, Kei Takasawa, Tomohiro Morio, Yukihiro Hasegawa, Kenichi Kashimada. Lower body weight and BMI at birth were associated with early adiposity rebound in 21-hydroxylase deficiency patients. Endocr. J.. 2016.11; 63 (11): 983-990. ( PubMed, DOI )

  197. Shumpei Yokota, Yasuhiko Itoh, Tomohiro Morio, Hideki Origasa, Naokata Sumitomo, Minako Tomobe, Kunihiko Tanaka, Seiji Minota. Tocilizumab in systemic juvenile idiopathic arthritis in a real-world clinical setting: results from 1 year of postmarketing surveillance follow-up of 417 patients in Japan. Ann. Rheum. Dis.. 2016.10; 75 (9): 1654-1660. ( PubMed, DOI )

  198. Takeshi Sato, Tsubasa Okano, Mari Tanaka-Kubota, Shunsuke Kimura, Satoshi Miyamoto, Shintaro Ono, Motoi Yamashita, Noriko Mitsuiki, Masatoshi Takagi, Kohsuke Imai, Michiko Kajiwara, Takasuke Ebato, Shohei Ogata, Hirotsugu Oda, Osamu Ohara, Hirokazu Kanegane, Tomohiro Morio. Novel compound heterozygous mutations in a Japanese girl with Janus kinase 3 deficiency. Pediatr Int. 2016.10; 58 (10): 1076-1080. ( PubMed, DOI )

  199. Masakatsu Yanagimachi, Takashi Ohya, Tomoko Yokosuka, Ryosuke Kajiwara, Fumiko Tanaka, Hiroaki Goto, Takehiro Takashima, Tomohiro Morio, Shumpei Yokota. The Potential and Limits of Hematopoietic Stem Cell Transplantation for the Treatment of Autosomal Dominant Hyper-IgE Syndrome. J. Clin. Immunol.. 2016.04; 36 (5): 511-516. ( PubMed, DOI )

  200. Julie Toubiana, Satoshi Okada, Julia Hiller, Matias Oleastro, Macarena Lagos Gomez, Juan Carlos Aldave Becerra, Marie Ouachée-Chardin, Fanny Fouyssac, Katta Mohan Girisha, Amos Etzioni, Joris Van Montfrans, Yildiz Camcioglu, Leigh Ann Kerns, Bernd Belohradsky, Stéphane Blanche, Aziz Bousfiha, Carlos Rodriguez-Gallego, Isabelle Meyts, Kai Kisand, Janine Reichenbach, Ellen D Renner, Sergio Rosenzweig, Bodo Grimbacher, Frank L van de Veerdonk, Claudia Traidl-Hoffmann, Capucine Picard, Laszlo Marodi, Tomohiro Morio, Masao Kobayashi, Desa Lilic, Joshua D Milner, Steven Holland, Jean-Laurent Casanova, Anne Puel. Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype: an international survey of 274 patients from 167 kindreds. Blood. 2016.04; 127 (25): 3154-3164. ( PubMed, DOI )

  201. Kazuhiro Ikegame, Kohsuke Imai, Motoi Yamashita, Akihiro Hoshino, Hirokazu Kanegane, Tomohiro Morio, Katsuji Kaida, Takayuki Inoue, Toshihiro Soma, Hiroya Tamaki, Masaya Okada, Hiroyasu Ogawa. Allogeneic stem cell transplantation for X-linked agammaglobulinemia using reduced intensity conditioning as a model of the reconstitution of humoral immunity. J Hematol Oncol. 2016.02; 9 (1): 9. ( PubMed, DOI )

  202. A Arai, C Sakashita, C Hirose, K-I Imadome, M Yamamoto, M Jinta, S Fujiwara, M Tomita, N Shimizu, T Morio, O Miura. Hematopoietic stem cell transplantation for adults with EBV-positive T- or NK-cell lymphoproliferative disorders: efficacy and predictive markers. Bone Marrow Transplant.. 2016.02; 51 (6): 879-882. ( PubMed, DOI )

  203. Yumiko Nakano, Takeshi Hayashi, Kentaro Deguchi, Kota Sato, Nozomi Hishikawa, Toru Yamashita, Yasuyuki Ohta, Yoshiki Takao, Tomohiro Morio, Koji Abe. Two young stroke patients associated with regular intravenous immunoglobulin (IVIg) therapy. J. Neurol. Sci.. 2016.02; 361 9-12. ( PubMed, DOI )

  204. T Muto, Y Takeda, S Tsukamoto, S Sakai, N Mimura, C Ohwada, M Takeuchi, E Sakaida, S Ota, T Iseki, N Shimizu, T Morio, C Nakaseko. Successful treatment of cytomegalovirus enteritis after unrelated allogeneic stem cell transplantation by the infusion of ex vivo-expanded CD4(+) lymphocytes derived from the recipient's peripheral blood donor cells. Transpl Infect Dis. 2016.02; 18 (1): 93-97. ( PubMed, DOI )

  205. Kei Takasawa, Sayaka Takeda, Masato Nishioka, Hiroshi Sakuma, Tomohiro Morio, Masayuki Shimohira. Steroid-responsive Status Epilepticus Caused by Human Parvovirus B19 Encephalitis. Pediatr. Infect. Dis. J.. 2016.02; 35 (2): 227-228. ( PubMed, DOI )

  206. Seiichi Hayakawa, Satoshi Okada, Miyuki Tsumura, Sonoko Sakata, Yoshitaka Ueno, Kohsuke Imai, Tomohiro Morio, Osamu Ohara, Kazuaki Chayama, Masao Kobayashi. A Patient with CTLA-4 Haploinsufficiency Presenting Gastric Cancer. J. Clin. Immunol.. 2016.01; 36 (1): 28-32. ( PubMed, DOI )

  207. Laura Gámez-Díaz, Dietrich August, Polina Stepensky, Shoshana Revel-Vilk, Markus G Seidel, Mitsuiki Noriko, Tomohiro Morio, Austen J J Worth, Jacob Blessing, Frank Van de Veerdonk, Tobias Feuchtinger, Maria Kanariou, Annette Schmitt-Graeff, Sophie Jung, Suranjith Seneviratne, Siobhan Burns, Bernd H Belohradsky, Nima Rezaei, Shahrzad Bakhtiar, Carsten Speckmann, Michael Jordan, Bodo Grimbacher. The extended phenotype of LPS-responsive beige-like anchor protein (LRBA) deficiency. J. Allergy Clin. Immunol.. 2016.01; 137 (1): 223-230. ( PubMed, DOI )

  208. Yuki Aoki, Reiji Miyawaki, Kohsuke Imai, Masatoshi Takagi, Michiko Kajiwara, Yasuyoshi Ishiwata, Masato Yasuhara, Tomohiro Morio, Shuki Mizutani, Daisuke Tomizawa. Haploidentical Bone Marrow Transplantation With Clofarabine and Busulfan Conditioning for a Child With Multiple Recurrent Acute Lymphoblastic Leukemia. J. Pediatr. Hematol. Oncol.. 2016.01; 38 (1): 39-41. ( PubMed, DOI )

  209. Tomohiro Kohmoto, Atsumi Tsuji, Kei-Ichi Morita, Takuya Naruto, Kiyoshi Masuda, Kenichi Kashimada, Keisuke Enomoto, Tomohiro Morio, Hiroyuki Harada, Issei Imoto. A novel COL11A1 missense mutation in siblings with non-ocular Stickler syndrome. Hum Genome Var. 2016; 3 16003. ( PubMed, DOI )

  210. Kotaro Kai, Maki Sumida, Yaeko Motoyoshi, Yuichi Ogawa, Katsuyuki Miki, Kazuhiro Iwadoh, Akihito Sannomiya, Toru Murakami, Ichiro Koyama, Kumiko Kitajima, Ichiro Nakajima, Tomohiro Morio, Shohei Fuchinoue. Successful Long-term Graft Survival of a Renal Transplantation Patient with Wiskott-Aldrich Syndrome. Intern. Med.. 2016; 55 (13): 1761-1763. ( PubMed, DOI )

  211. T Wada, Toma T, M Yasui, M Inoue, K Kawa, K Imai, T Morio, A Yachie. Different Clinical Phenotypes in 2 Siblings With X-Linked Severe Combined Immunodeficiency. J Investig Allergol Clin Immunol. 2016; 26 (1): 63-65. ( PubMed )

  212. 遠藤彰,吉川俊輔,大友康裕,森尾友宏. 重症敗血症・敗血症性ショックにおける好中球機能の変化の検討 バイオメディカル. 2015.12; 25 2-8. ( ichushi )

  213. Atsumi Tsuji, Kaoru Konishi, Satomi Hasegawa, Akira Anazawa, Toshikazu Onishi, Makoto Ono, Tomohiro Morio, Teruo Kitagawa, Kenichi Kashimada. Newborn screening for congenital adrenal hyperplasia in Tokyo, Japan from 1989 to 2013: a retrospective population-based study. BMC Pediatr. 2015.12; 15 (1): 209. ( PubMed, DOI )

  214. Koichi Oshima, Kohsuke Imai, Michael H Albert, Tanja C Bittner, Gabriele Strauss, Alexandra H Filipovich, Tomohiro Morio, Neena Kapoor, Jignesh Dalal, Kirk R Schultz, James T Casper, Luigi D Notarangelo, Hans D Ochs, Shigeaki Nonoyama. Hematopoietic Stem Cell Transplantation for X-Linked Thrombocytopenia With Mutations in the WAS gene. J. Clin. Immunol.. 2015.11; 35 (1): 15-21. ( PubMed, DOI )

  215. Kei Takasawa, Shigeru Takishima, Chikako Morioka, Masato Nishioka, Hirofumi Ohashi, Yoko Aoki, Masayuki Shimohira, Kenichi Kashimada, Tomohiro Morio. Improved growth velocity of a patient with Noonan-like syndrome with loose anagen hair (NS/LAH) without growth hormone deficiency by low-dose growth hormone therapy. Am. J. Med. Genet. A. 2015.10; 167A (10): 2425-2429. ( PubMed, DOI )

  216. Keisuke Nakajima, Shinobu Hirai, Tomohiro Morio, Haruo Okado. Benzodiazepines induce sequelae in immature mice with inflammation-induced status epilepticus. Epilepsy Behav. 2015.10; 52 (Pt A): 180-186. ( PubMed, DOI )

  217. Shinobu Tamura, Kohei Higuchi, Masaharu Tamaki, Chizuko Inoue, Ryoko Awazawa, Noriko Mitsuki, Yuka Nakazawa, Hiroyuki Mishima, Kenzo Takahashi, Osamu Kondo, Kohsuke Imai, Tomohiro Morio, Osamu Ohara, Tomoo Ogi, Fukumi Furukawa, Masami Inoue, Koh-Ichiro Yoshiura, Nobuo Kanazawa. Novel compound heterozygous DNA ligase IV mutations in an adolescent with a slowly-progressing radiosensitive-severe combined immunodeficiency. Clin. Immunol.. 2015.10; 160 (2): 255-260. ( PubMed, DOI )

  218. Takao Hayakawa, Takashi Aoi, Christopher Bravery, Karin Hoogendoorn, Ivana Knezevic, Junichi Koga, Daisuke Maeda, Akifumi Matsuyama, James McBlane, Tomohiro Morio, John Petricciani, Mahendra Rao, Anthony Ridgway, Daisaku Sato, Yoji Sato, Glyn Stacey, Norihisa Sakamoto, Jean-Hugues Trouvin, Akihiro Umezawa, Masayuki Yamato, Kazuo Yano, Hiroyuki Yokote, Kentaro Yoshimatsu, Pierrette Zorzi-Morre. Report of the international conference on regulatory endeavors towards the sound development of human cell therapy products. Biologicals. 2015.09; 43 (5): 283-297. ( PubMed, DOI )

  219. Tomoya Muto, Chikako Ohwada, Atsuko Yamazaki, Yasumasa Sugita, Shokichi Tsukamoto, Shio Sakai, Yusuke Takeda, Naoya Mimura, Masahiro Takeuchi, Emiko Sakaida, Tohru Iseki, Norio Shimizu, Tomohiro Morio, Chiaki Nakaseko. Long-term complete remission by infusion of ex vivo-expanded donor-derived CD4(+) lymphocytes for treating an early relapse of Hodgkin lymphoma after cord blood transplantation. Leuk. Lymphoma. 2015.05; 1-11. ( PubMed, DOI )

  220. Go Matsuda, Ken-Ichi Imadome, Fuyuko Kawano, Masashi Mochizuki, Nakaba Ochiai, Tomohiro Morio, Norio Shimizu, Shigeyoshi Fujiwara. Cellular immunotherapy with ex vivo expanded cord blood T cells in a humanized mouse model of EBV-associated lymphoproliferative disease. Immunotherapy. 2015.04; 7 (4): 335-341. ( PubMed, DOI )

  221. Shumpei Yokota, Yasuhiko Itoh, Tomohiro Morio, Naokata Sumitomo, Kaori Daimaru, Seiji Minota. Macrophage Activation Syndrome in Patients with Systemic Juvenile Idiopathic Arthritis under Treatment with Tocilizumab. J. Rheumatol.. 2015.04; 42 (4): 712-722. ( PubMed, DOI )

  222. Tamaki Kato, Elena Crestani, Chikako Kamae, Kenichi Honma, Tomoko Yokosuka, Takeshi Ikegawa, Naonori Nishida, Hirokazu Kanegane, Taizo Wada, Akihiro Yachie, Osamu Ohara, Tomohiro Morio, Luigi D Notarangelo, Kohsuke Imai, Shigeaki Nonoyama. RAG1 Deficiency May Present Clinically as Selective IgA Deficiency. J. Clin. Immunol.. 2015.04; 35 (3): 280-288. ( PubMed, DOI )

  223. Yohei Matsubara, Tomoko Kato, Kenichi Kashimada, Hiromitsu Tanaka, Zhou Zhi, Shizuko Ichinose, Shuki Mizutani, Tomohiro Morio, Tomoki Chiba, Yoshiaki Ito, Yumiko Saga, Shuji Takada, Hiroshi Asahara. TALEN-Mediated Gene Disruption on Y Chromosome Reveals Critical Role of EIF2S3Y in Mouse Spermatogenesis. Stem Cells Dev.. 2015.03; 24 (10): 1164-1170. ( PubMed, DOI )

  224. Noriko Mitsuiki, Xi Yang, Sophinus J W Bartol, Christina Grosserichter-Wagener, Yoshiyuki Kosaka, Hidetoshi Takada, Kohsuke Imai, Hirokazu Kanegane, Shuki Mizutani, Mirjam van der Burg, Menno C van Zelm, Osamu Ohara, Tomohiro Morio. Mutations in Bruton's tyrosine kinase impair IgA responses. Int. J. Hematol.. 2015.03; 101 (3): 305-313. ( PubMed, DOI )

  225. Kanako Mitsui-Sekinaka, Kohsuke Imai, Hiroki Sato, Daisuke Tomizawa, Michiko Kajiwara, Masayuki Nagasawa, Tomohiro Morio, Shigeaki Nonoyama. Clinical features and hematopoietic stem cell transplantations for CD40 ligand deficiency in Japan. J. Allergy Clin. Immunol.. 2015.03; 136 (4): 1018-1024. ( PubMed, DOI )

  226. Teppei Ohkawa, Satoshi Miyamoto, Manabu Sugie, Daisuke Tomizawa, Kohsuke Imai, Masayuki Nagasawa, Tomohiro Morio, Shuki Mizutani, Masatoshi Takagi. Transient abnormal myelopoiesis in non-Down syndrome neonate. Pediatr Int. 2015.02; 57 (1): 14-17. ( PubMed, DOI )

  227. Tomohito Takimoto, Hidetoshi Takada, Masataka Ishimura, Makiko Kirino, Kenichiro Hata, Osamu Ohara, Tomohiro Morio, Toshiro Hara. Wiskott-Aldrich Syndrome in a Girl Caused by Heterozygous WASP Mutation and Extremely Skewed X-Chromosome Inactivation: A Novel Association with Maternal Uniparental Isodisomy 6. Neonatology. 2015; 107 (3): 185-190. ( PubMed, DOI )

  228. Tae-Yoon Park, Sung-Dong Park, Jen-Young Cho, Jae-Seung Moon, Na-Yeon Kim, Kyungsoo Park, Rho Hyun Seong, Sang-Won Lee, Tomohiro Morio, Alfred L M Bothwell, Sang-Kyou Lee. RORγt-specific transcriptional interactomic inhibition suppresses autoimmunity associated with TH17 cells. Proc. Natl. Acad. Sci. U.S.A.. 2014.12; 111 (52): 18673-18678. ( PubMed, DOI )

  229. Masaaki Mori, Masafumi Onodera, Akira Morimoto, Yoshiyuki Kosaka, Tomohiro Morio, Gerard F Notario, Shringi Sharma, Tsutomu Saji. Palivizumab use in Japanese infants and children with immunocompromised conditions. Pediatr. Infect. Dis. J.. 2014.11; 33 (11): 1183-1185. ( PubMed, DOI )

  230. Yasuhiro Yamazaki, Masafumi Yamada, Toshinao Kawai, Tomohiro Morio, Masafumi Onodera, Masahiro Ueki, Nobuyuki Watanabe, Hidetoshi Takada, Shunichiro Takezaki, Natsuko Chida, Ichiro Kobayashi, Tadashi Ariga. Two novel gain-of-function mutations of STAT1 responsible for chronic mucocutaneous candidiasis disease: impaired production of IL-17A and IL-22, and the presence of anti-IL-17F autoantibody. J. Immunol.. 2014.11; 193 (10): 4880-4887. ( PubMed, DOI )

  231. K Nakatani, K Imai, M Shigeno, H Sato, M Tezuka, T Okawa, N Mitsuiki, T Isoda, D Tomizawa, M Takagi, M Nagasawa, M Kajiwara, M Yamamoto, A Arai, O Miura, C Kamae, N Nakagawa, K Honma, S Nonoyama, S Mizutani, T Morio. Cord blood transplantation is associated with rapid B-cell neogenesis compared with BM transplantation. Bone Marrow Transplant.. 2014.09; 49 (9): 1155-1161. ( PubMed, DOI )

  232. Akihiro Hoshino, Kohsuke Imai, Yusei Ohshima, Motoko Yasutomi, Masashi Kasai, Masaru Terai, Keiko Ishigaki, Tomohiro Morio, Toshio Miyawaki, Hirokazu Kanegane. Pneumothorax in patients with severe combined immunodeficiency. Pediatr Int. 2014.08; 56 (4): 510-514. ( PubMed, DOI )

  233. Akifumi Endo, Ken Watanabe, Tamae Ohye, Kyoko Suzuki, Tomoyo Matsubara, Norio Shimizu, Hiroki Kurahashi, Tetsushi Yoshikawa, Harutaka Katano, Naoki Inoue, Kohsuke Imai, Masatoshi Takagi, Tomohiro Morio, Shuki Mizutani. Molecular and Virological Evidence of Viral Activation From Chromosomally Integrated Human Herpesvirus 6A in a Patient With X-Linked Severe Combined Immunodeficiency. Clin. Infect. Dis.. 2014.08; 59 (4): 545-548. ( PubMed, DOI )

  234. Masaaki Mori, Tomohiro Morio, Shuichi Ito, Akira Morimoto, Setsuo Ota, Koichi Mizuta, Tsutomu Iwata, Toshiro Hara, Tsutomu Saji. Risks and prevention of severe RS virus infection among children with immunodeficiency and Down's syndrome. J. Infect. Chemother.. 2014.08; 20 (8): 455-459. ( PubMed, DOI )

  235. Kei Takasawa, Makoto Ono, Atsushi Hijikata, Yohei Matsubara, Noriyuki Katsumata, Masatoshi Takagi, Tomohiro Morio, Osamu Ohara, Kenichi Kashimada, Shuki Mizutani. Two novel HSD3B2 missense mutations with diverse residual enzymatic activities for Δ5-steroids. Clin. Endocrinol. (Oxf). 2014.06; 80 (6): 782-789. ( PubMed, DOI )

  236. Kei Takasawa, Kenichi Kashimada, Emanuele Pelosi, Masatoshi Takagi, Tomohiro Morio, Hiroshi Asahara, David Schlessinger, Shuki Mizutani, Peter Koopman. FOXL2 transcriptionally represses Sf1 expression by antagonizing WT1 during ovarian development in mice. FASEB J.. 2014.05; 28 (5): 2020-2028. ( PubMed, DOI )

  237. Setsuko Hasegawa, Kohsuke Imai, Kenichi Yoshida, Yusuke Okuno, Hideki Muramatsu, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seiji Kojima, Seishi Ogawa, Tomohiro Morio, Shuki Mizutani, Masatoshi Takagi. Whole-exome sequence analysis of ataxia telangiectasia-like phenotype. J. Neurol. Sci.. 2014.05; 340 (1-2): 86-90. ( PubMed, DOI )

  238. Shin Fukuda, Toshihiro Nanki, Tomohiro Morio, Hisanori Hasegawa, Ryuji Koike, Nobuyuki Miyasaka. Recurrent mitral valve regurgitation with neutrophil infiltration in a patient with multiple aseptic abscesses. Mod Rheumatol. 2014.05; 24 (3): 537-539. ( PubMed, DOI )

  239. Yoko Mizoguchi, Miyuki Tsumura, Satoshi Okada, Osamu Hirata, Shizuko Minegishi, Kohsuke Imai, Nobuyuki Hyakuna, Hideki Muramatsu, Seiji Kojima, Yusuke Ozaki, Takehide Imai, Sachiyo Takeda, Tetsuya Okazaki, Tsuyoshi Ito, Shin'ichiro Yasunaga, Yoshihiro Takihara, Vanessa L Bryant, Xiao-Fei Kong, Sophie Cypowyj, Stéphanie Boisson-Dupuis, Anne Puel, Jean-Laurent Casanova, Tomohiro Morio, Masao Kobayashi. Simple diagnosis of STAT1 gain-of-function alleles in patients with chronic mucocutaneous candidiasis. J. Leukoc. Biol.. 2014.04; 95 (4): 667-676. ( PubMed, DOI )

  240. Beatriz E Marciano, Chiung-Yu Huang, Gyan Joshi, Nima Rezaei, Beatriz Costa Carvalho, Zoe Allwood, Aydan Ikinciogullari, Shereen M Reda, Andrew Gennery, Vojtech Thon, Francisco Espinosa-Rosales, Waleed Al-Herz, Oscar Porras, Anna Shcherbina, Anna Szaflarska, Şebnem Kiliç, Jose L Franco, Andrea C Gómez Raccio, Persio Roxo, Isabel Esteves, Nermeen Galal, Anete Sevciovic Grumach, Salem Al-Tamemi, Alisan Yildiran, Julio C Orellana, Masafumi Yamada, Tomohiro Morio, Diana Liberatore, Yoshitoshi Ohtsuka, Yu-Lung Lau, Ryuta Nishikomori, Carlos Torres-Lozano, Juliana T L Mazzucchelli, Maria M S Vilela, Fabiola S Tavares, Luciana Cunha, Jorge A Pinto, Sara E Espinosa-Padilla, Leticia Hernandez-Nieto, Reem A Elfeky, Tadashi Ariga, Heike Toshio, Figen Dogu, Funda Cipe, Renata Formankova, M Enriqueta Nuñez-Nuñez, Liliana Bezrodnik, Jose Gonçalo Marques, María I Pereira, Viviana Listello, Mary A Slatter, Zohreh Nademi, Danuta Kowalczyk, Thomas A Fleisher, Graham Davies, Bénédicte Neven, Sergio D Rosenzweig. BCG vaccination in patients with severe combined immunodeficiency: complications, risks, and vaccination policies. J. Allergy Clin. Immunol.. 2014.04; 133 (4): 1134-1141. ( PubMed, DOI )

  241. Shigeyoshi Fujiwara, Hiroshi Kimura, Ken-ichi Imadome, Ayako Arai, Eiichi Kodama, Tomohiro Morio, Norio Shimizu, Hiroshi Wakiguchi. Current research on chronic active Epstein-Barr virus infection in Japan. Pediatr Int. 2014.04; 56 (2): 159-166. ( PubMed, DOI )

  242. Yohei Matsubara, Tomoki Chiba, Kenichi Kashimada, Tomohiro Morio, Shuji Takada, Shuki Mizutani, Hiroshi Asahara. Transcription activator-like effector nuclease-mediated transduction of exogenous gene into IL2RG locus. Sci Rep. 2014; 4 5043. ( PubMed, DOI )

  243. U Koura, H Sakaki-Nakatsubo, K Otsubo, K Nomura, K Oshima, O Ohara, T Wada, A Yachie, K Imai, T Morio, T Miyawaki, H Kanegane. Successful treatment of systemic cytomegalovirus infection in severe combined immunodeficiency using allogeneic bone marrow transplantation followed by adoptive immunotherapy. J Investig Allergol Clin Immunol. 2014; 24 (3): 200-202. ( PubMed )

  244. Masayuki Nagasawa, Teppei Ohkawa, Akifumi Endo, Noriko Mitsuiki, Toshiaki Ono, Yuki Aoki, Takeshi Isoda, Daisuke Tomizawa, Masatoshi Takagi, Michiko Kajiwara, Tomohiro Morio, Shuki Mizutani. Early coagulation disorder after allogeneic stem cell transplantation is a strong prognostic factor for transplantation-related mortality, and intervention with recombinant human thrombomodulin improves the outcome: a single-center experience. Int. J. Hematol.. 2013.11; 98 (5): 533-542. ( PubMed, DOI )

  245. Sunao Sugita, Manabu Ogawa, Norio Shimizu, Tomohiro Morio, Nobuyuki Ohguro, Kei Nakai, Kazuichi Maruyama, Kenji Nagata, Atsunobu Takeda, Yoshihiko Usui, Koh-Hei Sonoda, Masaru Takeuchi, Manabu Mochizuki. Use of a comprehensive polymerase chain reaction system for diagnosis of ocular infectious diseases. Ophthalmology. 2013.09; 120 (9): 1761-1768. ( PubMed, DOI )

  246. Satoru Kumaki, Yoji Sasahara, Yoshiro Kamachi, Hideki Muramatsu, Tomohiro Morio, Kumiko Goi, Kanji Sugita, Tomonari Urabe, Hidetoshi Takada, Seiji Kojima, Shigeru Tsuchiya, Toshirou Hara. B-cell function after unrelated umbilical cord blood transplantation using a minimal-intensity conditioning regimen in patients with X-SCID. Int. J. Hematol.. 2013.09; 98 (3): 355-360. ( PubMed, DOI )

  247. Shizuka Machida, Daisuke Tomizawa, Hiroyuki Tamaichi, Teppei Okawa, Akifumi Endo, Kohsuke Imai, Masayuki Nagasawa, Tomohiro Morio, Shuki Mizutani, Masatoshi Takagi. Successful treatment of diffuse large B-cell lymphoma in a patient with ataxia telangiectasia using rituximab. J. Pediatr. Hematol. Oncol.. 2013.08; 35 (6): 482-485. ( PubMed, DOI )

  248. Junya Unno, Masatoshi Takagi, Jinhua Piao, Masataka Sugimoto, Fumiko Honda, Daisuke Maeda, Mitsuko Masutani, Tohru Kiyono, Fumiaki Watanabe, Tomohiro Morio, Hirobumi Teraoka, Shuki Mizutani. Artemis-dependent DNA double-strand break formation at stalled replication forks. Cancer Sci.. 2013.06; 104 (6): 703-710. ( PubMed, DOI )

  249. Chikako Kamae, Noriko Nakagawa, Hiroki Sato, Kenichi Honma, Noriko Mitsuiki, Osamu Ohara, Hirokazu Kanegane, Srdjan Pasic, Qiang Pan-Hammarström, Menno C van Zelm, Tomohiro Morio, Kohsuke Imai, Shigeaki Nonoyama. Common variable immunodeficiency classification by quantifying T-cell receptor and immunoglobulin κ-deleting recombination excision circles. J. Allergy Clin. Immunol.. 2013.05; 131 (5): 1437-40.e5. ( PubMed, DOI )

  250. Taizo Wada, Masahiro Muraoka, Tomoko Toma, Tsuyoshi Imai, Tomonari Shigemura, Kazunaga Agematsu, Kohei Haraguchi, Hiroyuki Moriuchi, Tsutomu Oh-Ishi, Toshiyuki Kitoh, Osamu Ohara, Tomohiro Morio, Akihiro Yachie. Rapid detection of intracellular p47phox and p67phox by flow cytometry; useful screening tests for chronic granulomatous disease. J. Clin. Immunol.. 2013.05; 33 (4): 857-864. ( PubMed, DOI )

  251. Ayami Yoshimi, Yoshiro Kamachi, Kosuke Imai, Nobuhiro Watanabe, Hisaya Nakadate, Takashi Kanazawa, Shuichi Ozono, Ryoji Kobayashi, Misa Yoshida, Chie Kobayashi, Asahito Hama, Hideki Muramatsu, Yoji Sasahara, Marcus Jakob, Tomohiro Morio, Stephan Ehl, Atsushi Manabe, Charlotte Niemeyer, Seiji Kojima. Wiskott-Aldrich syndrome presenting with a clinical picture mimicking juvenile myelomonocytic leukaemia. Pediatr Blood Cancer. 2013.05; 60 (5): 836-841. ( PubMed, DOI )

  252. Takeshi Isoda, Noriko Mitsuiki, Teppei Ohkawa, Setsuko Kaneko, Akifumi Endo, Toshiaki Ono, Yuki Aoki, Daisuke Tomizawa, Michiko Kajiwara, Satoshi Araki, Masayuki Nagasawa, Tomohiro Morio, Masatoshi Takagi, Shuki Mizutani. Irreversible leukoencephalopathy after reduced-intensity stem cell transplantation in a dyskeratosis congenita patient with TINF2 mutation. J. Pediatr. Hematol. Oncol.. 2013.05; 35 (4): e178-e182. ( PubMed, DOI )

  253. Tae-Yoon Park, Seung-Hyung Kim, Yoon-Chul Shin, Nae-Hyun Lee, Rae-Kyung Christina Lee, Jae-Hyuck Shim, Laurie H Glimcher, Inhee Mook-Jung, Eunji Cheong, Won-Ki Kim, Fumiko Honda, Tomohiro Morio, Jong-Soon Lim, Sang-Kyou Lee. Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin. J Control Release. 2013.03; 166 (3): 307-315. ( PubMed, DOI )

  254. Masaki Shimizu, Hirokazu Kanegane, Taizo Wada, Yaeko Motoyoshi, Tomohiro Morio, Fabio Candotti, Akihiro Yachie. Aberrant glycosylation of IgA in Wiskott-Aldrich syndrome and X-linked thrombocytopenia. J. Allergy Clin. Immunol.. 2013.02; 131 (2): 587-90.e1. ( PubMed, DOI )

  255. Chie Miyabe, Yoshishige Miyabe, Noriko N Miura, Kei Takahashi, Yuya Terashima, Etsuko Toda, Fumiko Honda, Tomohiro Morio, Naoko Yamagata, Naohito Ohno, Koichi Shudo, Jun-ichi Suzuki, Mitsuaki Isobe, Kouji Matsushima, Ryoji Tsuboi, Nobuyuki Miyasaka, Toshihiro Nanki. Am80, a retinoic acid receptor agonist, ameliorates murine vasculitis through the suppression of neutrophil migration and activation. Arthritis Rheum.. 2013.02; 65 (2): 503-512. ( PubMed, DOI )

  256. Yukako Kawasaki, Hidemi Toyoda, Shoichiro Otsuki, Tadashi Iwasa, Shotaro Iwamoto, Eiichi Azuma, Naomi Itoh-Habe, Hideo Wada, Yoshihiro Fujimura, Tomohiro Morio, Kohsuke Imai, Noriko Mitsuiki, Osamu Ohara, Yoshihiro Komada. A novel Wiskott-Aldrich syndrome protein mutation in an infant with thrombotic thrombocytopenic purpura. Eur. J. Haematol.. 2013.02; 90 (2): 164-168. ( PubMed, DOI )

  257. Zen Kobayashi, Miho Akaza, Yoshiyuki Numasawa, Shoichiro Ishihara, Hiroyuki Tomimitsu, Kazuo Nakamichi, Masayuki Saijo, Tomohiro Morio, Norio Shimizu, Nobuo Sanjo, Shuzo Shintani, Hidehiro Mizusawa. Failure of mefloquine therapy in progressive multifocal leukoencephalopathy: report of two Japanese patients without human immunodeficiency virus infection. J. Neurol. Sci.. 2013.01; 324 (1-2): 190-194. ( PubMed, DOI )

  258. Yamamoto A, Morio T, Kumaki E, Yamazaki H, Iwai H, Kubota T, Miyasaka N, Kohsaka H. A Case of Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome Accompanied by Nephrosclerosis, Splenomegaly and Intestinal Lesions. J Genet Syndr Gene Ther. . 2013; 4 e9.

  259. Takafumi Nozaki, Hidetoshi Takada, Masataka Ishimura, Kenji Ihara, Kohsuke Imai, Tomohiro Morio, Masao Kobayashi, Shigeaki Nonoyama, Toshiro Hara. Endocrine complications in primary immunodeficiency diseases in Japan. Clin. Endocrinol. (Oxf). 2012.10; 77 (4): 628-634. ( PubMed, DOI )

  260. Yoshiko Uchida, Kousaku Matsubara, Tamaki Wada, Kazunori Oishi, Tomohiro Morio, Hidetoshi Takada, Aya Iwata, Kazuo Yura, Katsunori Kamimura, Hiroyuki Nigami, Takashi Fukaya. Recurrent bacterial meningitis by three different pathogens in an isolated asplenic child. J. Infect. Chemother.. 2012.08; 18 (4): 576-580. ( PubMed, DOI )

  261. Takeshi Isoda, Masatoshi Takagi, Jinhua Piao, Shun Nakagama, Masaki Sato, Kyoko Masuda, Tomokatsu Ikawa, Miyuki Azuma, Tomohiro Morio, Hiroshi Kawamoto, Shuki Mizutani. Process for immune defect and chromosomal translocation during early thymocyte development lacking ATM. Blood. 2012.07; 120 (4): 789-799. ( PubMed, DOI )

  262. Fumiko Honda, Hirotsugu Kano, Hirokazu Kanegane, Shigeaki Nonoyama, Eun-Sung Kim, Sang-Kyou Lee, Masatoshi Takagi, Shuki Mizutani, Tomohiro Morio. The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils. Nat. Immunol.. 2012.04; 13 (4): 369-378. ( PubMed, DOI )

  263. Yoshiko Uchida, Kousaku Matsubara, Tomohiro Morio, Yu Kawasaki, Aya Iwata, Kazuo Yura, Katsunori Kamimura, Hiroyuki Nigami, Takashi Fukaya. Acute cerebellitis and concurrent encephalitis associated with parvovirus B19 infection. Pediatr. Infect. Dis. J.. 2012.04; 31 (4): 427. ( PubMed, DOI )

  264. Keisuke Nakajima, Masaharu Hayashi, Naoyuki Tanuma, Tomohiro Morio. An autopsy case of polymicrogyria and intracerebral calcification with death by intracerebral hemorrhage. Neuropathology. 2012.04; 32 (2): 207-210. ( PubMed, DOI )

  265. Madoka Kuramitsu, Aiko Sato-Otsubo, Tomohiro Morio, Masatoshi Takagi, Tsutomu Toki, Kiminori Terui, RuNan Wang, Hitoshi Kanno, Shouichi Ohga, Akira Ohara, Seiji Kojima, Toshiyuki Kitoh, Kumiko Goi, Kazuko Kudo, Tadashi Matsubayashi, Nobuo Mizue, Michio Ozeki, Atsuko Masumi, Haruka Momose, Kazuya Takizawa, Takuo Mizukami, Kazunari Yamaguchi, Seishi Ogawa, Etsuro Ito, Isao Hamaguchi. Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia. Blood. 2012.03; 119 (10): 2376-2384. ( PubMed, DOI )

  266. Rikiya Sato, Susumu Iiizumi, Eun-Sung Kim, Fumiko Honda, Sang-Kyou Lee, Noritaka Adachi, Hideki Koyama, Shuki Mizutani, Tomohiro Morio. Impaired cell adhesion, apoptosis, and signaling in WASP gene-disrupted Nalm-6 pre-B cells and recovery of cell adhesion using a transducible form of WASp. Int. J. Hematol.. 2012.03; 95 (3): 299-310. ( PubMed, DOI )

  267. Sang-Won Lee, Ji-Hye Kim, Min-Chan Park, Yong-Beom Park, Wook Jin Chae, Tomohiro Morio, Dong-Ho Lee, Sang-Hwa Yang, Seung-Kyou Lee, Soo-Kon Lee, Sang-Kyou Lee. Alleviation of rheumatoid arthritis by cell-transducible methotrexate upon transcutaneous delivery. Biomaterials. 2012.02; 33 (5): 1563-1572. ( PubMed, DOI )

  268. Sung Hee Jang, Joo Weon Lim, Tomohiro Morio, Hyeyoung Kim. Lycopene inhibits Helicobacter pylori-induced ATM/ATR-dependent DNA damage response in gastric epithelial AGS cells. Free Radic. Biol. Med.. 2012.02; 52 (3): 607-615. ( PubMed, DOI )

  269. Fumiko Honda, Yumiko Hane, Tomoko Toma, Akihiro Yachie, Eun-Sung Kim, Sang-Kyou Lee, Masatoshi Takagi, Shuki Mizutani, Tomohiro Morio. Transducible form of p47phox and p67phox compensate for defective NADPH oxidase activity in neutrophils of patients with chronic granulomatous disease. Biochem. Biophys. Res. Commun.. 2012.01; 417 (1): 162-168. ( PubMed, DOI )

  270. Kotoka Nakamura, Liutao Du, Rashmi Tunuguntla, Francesca Fike, Simona Cavalieri, Tomohiro Morio, Shuki Mizutani, Alfredo Brusco, Richard A Gatti. Functional characterization and targeted correction of ATM mutations identified in Japanese patients with ataxia-telangiectasia. Hum. Mutat.. 2012.01; 33 (1): 198-208. ( PubMed, DOI )

  271. Masataka Ishimura, Hidetoshi Takada, Takehiko Doi, Kousuke Imai, Yoji Sasahara, Hirokazu Kanegane, Ryuta Nishikomori, Tomohiro Morio, Toshio Heike, Masao Kobayashi, Tadashi Ariga, Shigeru Tsuchiya, Shigeaki Nonoyama, Toshio Miyawaki, Toshiro Hara. Nationwide survey of patients with primary immunodeficiency diseases in Japan. J. Clin. Immunol.. 2011.12; 31 (6): 968-976. ( PubMed, DOI )

  272. Keisuke Kato, Yasuko Kojima, Chie Kobayashi, Kazumasa Mitsui, Ryoko Nakajima-Yamaguchi, Kazuko Kudo, Toshihiro Yanai, Ai Yoshimi, Tomohei Nakao, Tomohiro Morio, Mureo Kasahara, Kazutoshi Koike, Masahiro Tsuchida. Successful allogeneic hematopoietic stem cell transplantation for chronic granulomatous disease with inflammatory complications and severe infection. Int. J. Hematol.. 2011.11; 94 (5): 479-482. ( PubMed, DOI )

  273. Ken-ichi Imadome, Misako Yajima, Ayako Arai, Atsuko Nakazawa, Fuyuko Kawano, Sayumi Ichikawa, Norio Shimizu, Naoki Yamamoto, Tomohiro Morio, Shouichi Ohga, Hiroyuki Nakamura, Mamoru Ito, Osamu Miura, Jun Komano, Shigeyoshi Fujiwara. Novel mouse xenograft models reveal a critical role of CD4+ T cells in the proliferation of EBV-infected T and NK cells. PLoS Pathog.. 2011.10; 7 (10): e1002326. ( PubMed, DOI )

  274. Tomohiro Morio, Yoshiko Atsuta, Daisuke Tomizawa, Tokiko Nagamura-Inoue, Koji Kato, Tadashi Ariga, Keisei Kawa, Kazutoshi Koike, Hisamichi Tauchi, Michiko Kajiwara, Toshiro Hara, Shunichi Kato, . Outcome of unrelated umbilical cord blood transplantation in 88 patients with primary immunodeficiency in Japan. Br. J. Haematol.. 2011.08; 154 (3): 363-372. ( PubMed, DOI )

  275. Masatoshi Takagi, Kunihiro Shinoda, Jinhua Piao, Noriko Mitsuiki, Mari Takagi, Kazuyuki Matsuda, Hideki Muramatsu, Sayoko Doisaki, Masayuki Nagasawa, Tomohiro Morio, Yoshihito Kasahara, Kenichi Koike, Seiji Kojima, Akira Takao, Shuki Mizutani. Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS mutation. Blood. 2011.03; 117 (10): 2887-2890. ( PubMed, DOI )

  276. Erika Asai, Taizo Wada, Yasuhisa Sakakibara, Akiko Toga, Tomoko Toma, Takashi Shimizu, Sheela Nampoothiri, Kohsuke Imai, Shigeaki Nonoyama, Tomohiro Morio, Hideki Muramatsu, Yoshiro Kamachi, Osamu Ohara, Akihiro Yachie. Analysis of mutations and recombination activity in RAG-deficient patients. Clin. Immunol.. 2011.02; 138 (2): 172-177. ( PubMed, DOI )

  277. Min-Jung Shin, Jae-Hyuck Shim, Jae-Young Lee, Wook-Jin Chae, Heung-Kyu Lee, Tomohiro Morio, Jun Han Park, Eun-Ju Chang, Sang-Kyou Lee. Qualitative and quantitative differences in the intensity of Fas-mediated intracellular signals determine life and death in T cells. Int. J. Hematol.. 2010.09; 92 (2): 262-270. ( PubMed, DOI )

  278. Mitsuru Seki, Hirokazu Kimura, Akio Mori, Akira Shimada, Yoshiyuki Yamada, Kenichi Maruyama, Yasuhide Hayashi, Kazunaga Agematsu, Tomohiro Morio, Akihiro Yachie, Masahiko Kato. Prominent eosinophilia but less eosinophil activation in a patient with Omenn syndrome. Pediatr Int. 2010.08; 52 (4): e196-e199. ( PubMed, DOI )

  279. Hirosuke Inoue, Hidetoshi Takada, Takeshi Kusuda, Takako Goto, Masayuki Ochiai, Tadamune Kinjo, Jun Muneuchi, Yasushi Takahata, Naomi Takahashi, Tomohiro Morio, Kenjiro Kosaki, Toshiro Hara. Successful cord blood transplantation for a CHARGE syndrome with CHD7 mutation showing DiGeorge sequence including hypoparathyroidism. Eur. J. Pediatr.. 2010.07; 169 (7): 839-844. ( PubMed, DOI )

  280. Daiju Oba, Masaharu Hayashi, Motoyuki Minamitani, Shinichiro Hamano, Naoki Uchisaka, Akira Kikuchi, Hiroshi Kishimoto, Masatoshi Takagi, Tomohiro Morio, Shuki Mizutani. Autopsy study of cerebellar degeneration in siblings with ataxia-telangiectasia-like disorder. Acta Neuropathol.. 2010.04; 119 (4): 513-520. ( PubMed, DOI )

  281. Michael H Albert, Tanja C Bittner, Shigeaki Nonoyama, Lucia Dora Notarangelo, Siobhan Burns, Kohsuke Imai, Teresa Espanol, Anders Fasth, Isabelle Pellier, Gabriele Strauss, Tomohiro Morio, Benjamin Gathmann, Jeroen G Noordzij, Cristina Fillat, Manfred Hoenig, Michaela Nathrath, Alfons Meindl, Philipp Pagel, Uwe Wintergerst, Alain Fischer, Adrian J Thrasher, Bernd H Belohradsky, Hans D Ochs. X-linked thrombocytopenia (XLT) due to WAS mutations: clinical characteristics, long-term outcome, and treatment options. Blood. 2010.04; 115 (16): 3231-3238. ( PubMed, DOI )

  282. Kazuo Okamoto, Yoshiko Iwai, Masatsugu Oh-Hora, Masahiro Yamamoto, Tomohiro Morio, Kazuhiro Aoki, Keiichi Ohya, Anton M Jetten, Shizuo Akira, Tatsushi Muta, Hiroshi Takayanagi. IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors. Nature. 2010.04; 464 (7293): 1381-1385. ( PubMed, DOI )

  283. Masaru Miyanaga, Sunao Sugita, Norio Shimizu, Tomohiro Morio, Kazunori Miyata, Kazuichi Maruyama, Shigeru Kinoshita, Manabu Mochizuki. A significant association of viral loads with corneal endothelial cell damage in cytomegalovirus anterior uveitis. Br J Ophthalmol. 2010.03; 94 (3): 336-340. ( PubMed, DOI )

  284. Yoichi Morinishi, Kohsuke Imai, Noriko Nakagawa, Hiroki Sato, Katsuyuki Horiuchi, Yoshitoshi Ohtsuka, Yumi Kaneda, Takashi Taga, Hiroaki Hisakawa, Ryosuke Miyaji, Mikiya Endo, Tsutomu Oh-Ishi, Yoshiro Kamachi, Koshi Akahane, Chie Kobayashi, Masahiro Tsuchida, Tomohiro Morio, Yoji Sasahara, Satoru Kumaki, Keiko Ishigaki, Makoto Yoshida, Tomonari Urabe, Norimoto Kobayashi, Yuri Okimoto, Janine Reichenbach, Yoshiko Hashii, Yoichiro Tsuji, Kazuhiro Kogawa, Seiji Yamaguchi, Hirokazu Kanegane, Toshio Miyawaki, Masafumi Yamada, Tadashi Ariga, Shigeaki Nonoyama. Identification of severe combined immunodeficiency by T-cell receptor excision circles quantification using neonatal guthrie cards. J. Pediatr.. 2009.12; 155 (6): 829-833. ( PubMed, DOI )

  285. Daiichiro Hasegawa, Michiko Kaji, Hiroki Takeda, Keiichiro Kawasaki, Hironobu Takahashi, Hiroshi Ochiai, Tomohiro Morio, Yasuhiro Omori, Hiroshi Yokozaki, Yoshiyuki Kosaka. Fatal degeneration of specialized cardiac muscle associated with chronic active Epstein-Barr virus infection. Pediatr Int. 2009.12; 51 (6): 846-848. ( PubMed, DOI )

  286. Yoshitaka Miyagawa, Nobutaka Kiyokawa, Nakaba Ochiai, Ken-ichi Imadome, Yasuomi Horiuchi, Keiko Onda, Misako Yajima, Hiroyuki Nakamura, Yohko U Katagiri, Hajime Okita, Tomohiro Morio, Norio Shimizu, Junichiro Fujimoto, Shigeyoshi Fujiwara. Ex vivo expanded cord blood CD4 T lymphocytes exhibit a distinct expression profile of cytokine-related genes from those of peripheral blood origin. Immunology. 2009.11; 128 (3): 405-419. ( PubMed, DOI )

  287. Tomohiro Morio, Naomi Takahashi, Fumiaki Watanabe, Fumiko Honda, Masaki Sato, Masatoshi Takagi, Ken-ichi Imadome, Toshio Miyawaki, Domenico Delia, Kotoka Nakamura, Richard A Gatti, Shuki Mizutani. Phenotypic variations between affected siblings with ataxia-telangiectasia: ataxia-telangiectasia in Japan. Int. J. Hematol.. 2009.11; 90 (4): 455-462. ( PubMed, DOI )

  288. Takeshi Isoda, Anthony M Ford, Daisuke Tomizawa, Frederik W van Delft, David Gonzalez De Castro, Norkio Mitsuiki, Joannah Score, Tomohiko Taki, Tomohiro Morio, Masatoshi Takagi, Hiroh Saji, Mel Greaves, Shuki Mizutani. Immunologically silent cancer clone transmission from mother to offspring. Proc. Natl. Acad. Sci. U.S.A.. 2009.10; 106 (42): 17882-17885. ( PubMed, DOI )

  289. Naoki Uchisaka, Naomi Takahashi, Masaki Sato, Akira Kikuchi, Shinji Mochizuki, Kohsuke Imai, Shigeaki Nonoyama, Osamu Ohara, Fumiaki Watanabe, Shuki Mizutani, Ryoji Hanada, Tomohiro Morio. Two brothers with ataxia-telangiectasia-like disorder with lung adenocarcinoma. J. Pediatr.. 2009.09; 155 (3): 435-438. ( PubMed, DOI )

  290. Hisao Yoshida, Shigenori Kusuki, Yoshiko Hashii, Hideaki Ohta, Tomohiro Morio, Keiichi Ozono. Ex vivo-expanded donor CD4(+) lymphocyte infusion against relapsing neuroblastoma: A transient graft-versus-tumor effect. Pediatr Blood Cancer. 2009.07; 52 (7): 895-897. ( PubMed, DOI )

  291. Naomi Takahashi, Kenji Matsumoto, Hirohisa Saito, Toshihiro Nanki, Nobuyuki Miyasaka, Tetsuji Kobata, Miyuki Azuma, Sang-Kyou Lee, Shuki Mizutani, Tomohiro Morio. Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients. J. Immunol.. 2009.05; 182 (9): 5515-5527. ( PubMed, DOI )

  292. 所正治, Hussein Amjad I.A., 田中身和, 山口智博, 森尾友宏, 佐藤隆介, 水谷修紀. 免疫低下に伴うMAC感染症に合併した呼吸器クリプトスポリジウム症の1例 Clinical Parasitology. 2009.02; 19 (1): 55-58. ( ichushi )

  293. M Honda, M Takagi, L Chessa, T Morio, S Mizuatni. Rapid diagnosis of ataxia-telangiectasia by flow cytometric monitoring of DNA damage-dependent ATM phosphorylation. Leukemia. 2009.02; 23 (2): 409-414. ( PubMed, DOI )

  294. Toshihiro Nanki, Kazuki Takada, Yukiko Komano, Tomohiro Morio, Hirokazu Kanegane, Atsuo Nakajima, Peter E Lipsky, Nobuyuki Miyasaka. Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis. Arthritis Res. Ther.. 2009; 11 (5): R149. ( PubMed, DOI )

  295. Yuri Futagami, Sunao Sugita, Takuro Fujimaki, Toshiyuki Yokoyama, Tomohiro Morio, Manabu Mochizuki. Bilateral anterior granulomatous keratouveitis with sunset glow fundus in a patient with autoimmune polyglandular syndrome. Ocul. Immunol. Inflamm.. 2009; 17 (2): 88-90. ( PubMed, DOI )

  296. S Sugita, N Shimizu, K Watanabe, M Mizukami, T Morio, Y Sugamoto, M Mochizuki. Use of multiplex PCR and real-time PCR to detect human herpes virus genome in ocular fluids of patients with uveitis. Br J Ophthalmol. 2008.07; 92 (7): 928-932. ( PubMed, DOI )

  297. Koichi Suzuki, Koji Tsugawa, Eishin Oki, Tomohiro Morio, Etsuro Ito, Hiroshi Tanaka. Vesical varices and telangiectasias in a patient with ataxia telangiectasia. Pediatr. Nephrol.. 2008.06; 23 (6): 1005-1008. ( PubMed, DOI )

  298. S Kido, S Sugita, S Horie, M Miyanaga, K Miyata, N Shimizu, T Morio, M Mochizuki. Association of varicella zoster virus load in the aqueous humor with clinical manifestations of anterior uveitis in herpes zoster ophthalmicus and zoster sine herpete. Br J Ophthalmol. 2008.04; 92 (4): 505-508. ( PubMed, DOI )

  299. Masahiro Shinohara, Takako Koga, Kazuo Okamoto, Shinya Sakaguchi, Kimiko Arai, Hisataka Yasuda, Toshiyuki Takai, Tatsuhiko Kodama, Tomohiro Morio, Raif S Geha, Daisuke Kitamura, Tomohiro Kurosaki, Wilfried Ellmeier, Hiroshi Takayanagi. Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell. 2008.03; 132 (5): 794-806. ( PubMed, DOI )

  300. Daiichiro Hasegawa, Masako Fukushima, Yuki Hosokawa, Hiroki Takeda, Keiichiro Kawasaki, Tomoyuki Mizukami, Hiroyuki Nunoi, Hiroshi Ochiai, Tomohiro Morio, Yoshiyuki Kosaka. Successful treatment of chronic granulomatous disease with fludarabine-based reduced-intensity conditioning and unrelated bone marrow transplantation. Int. J. Hematol.. 2008.01; 87 (1): 88-90. ( PubMed, DOI )

  301. Sayaka Yamamoto, Sunao Sugita, Yoshiharu Sugamoto, Norio Shimizu, Tomohiro Morio, Manabu Mochizuki. Quantitative PCR for the detection of genomic DNA of Epstein-Barr virus in ocular fluids of patients with uveitis. Jpn. J. Ophthalmol.. 2008; 52 (6): 463-467. ( PubMed, DOI )

  302. Tomohiro Morio, Hyeyoung Kim. Ku, Artemis, and ataxia-telangiectasia-mutated: signalling networks in DNA damage. Int. J. Biochem. Cell Biol.. 2008; 40 (4): 598-603. ( PubMed, DOI )

  303. Morio T. Strategy to Combat Opportunistic Infections after Umbilical Cord Blood Transplantation (UCBT) - Monitoring of Multiple Pathogens with a Novel Multiplex PCR System and Infusion of Ex-vivo Expanded CD4 T-Cells (CD4-DLI). Biol Blood Marrow Tr. . 2007.11; 13 (11): 1400-1401.

  304. S Horibe, M Takagi, J Unno, M Nagasawa, T Morio, A Arai, O Miura, M Ohta, M Kitagawa, S Mizutani. DNA damage check points prevent leukemic transformation in myelodysplastic syndrome. Leukemia. 2007.10; 21 (10): 2195-2198. ( PubMed, DOI )

  305. Sunao Sugita, Norio Shimizu, Tastushi Kawaguchi, Nobuaki Akao, Tomohiro Morio, Manabu Mochizuki. Identification of human herpesvirus 6 in a patient with severe unilateral panuveitis. Arch. Ophthalmol.. 2007.10; 125 (10): 1426-1427. ( PubMed, DOI )

  306. C Tono, Y Takahashi, K Terui, S Sasaki, T Kamio, S Tandai, T Sato, K Kudo, T Toki, N Tachibana, T Yoshioka, T Nakahata, T Morio, R Nishikomori, E Ito. Correction of immunodeficiency associated with NEMO mutation by umbilical cord blood transplantation using a reduced-intensity conditioning regimen. Bone Marrow Transplant.. 2007.06; 39 (12): 801-804. ( PubMed, DOI )

  307. H Okamoto, C Arii, F Shibata, T Toma, T Wada, M Inoue, Y Tone, Y Kasahara, S Koizumi, Y Kamachi, Y Ishida, J Inagaki, M Kato, T Morio, A Yachie. Clonotypic analysis of T cell reconstitution after haematopoietic stem cell transplantation (HSCT) in patients with severe combined immunodeficiency. Clin. Exp. Immunol.. 2007.06; 148 (3): 450-460. ( PubMed, DOI )

  308. Kumiko Ohnuma-Ishikawa, Tomohiro Morio, Takayuki Yamada, Yuji Sugawara, Makoto Ono, Masayuki Nagasawa, Akio Yasuda, Chikao Morimoto, Kei Ohnuma, Nam H Dang, Hajime Hosoi, Eric Verdin, Shuki Mizutani. Knockdown of XAB2 enhances all-trans retinoic acid-induced cellular differentiation in all-trans retinoic acid-sensitive and -resistant cancer cells. Cancer Res.. 2007.02; 67 (3): 1019-1029. ( PubMed, DOI )

  309. Satoru Watanabe, Kazuo Terashima, Shinrai Ohta, Shigeo Horibata, Misako Yajima, Yoko Shiozawa, M Zahidunnabi Dewan, Zhong Yu, Mamoru Ito, Tomohiro Morio, Norio Shimizu, Mitsuo Honda, Naoki Yamamoto. Hematopoietic stem cell-engrafted NOD/SCID/IL2Rgamma null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses. Blood. 2007.01; 109 (1): 212-218. ( PubMed, DOI )

  310. Jong Hwa Lee, Kyung Hwan Kim, Tomohiro Morio, Hyeyoung Kim. Ataxia-telangiectasia-mutated-dependent activation of Ku in human fibroblasts exposed to hydrogen peroxide. Ann. N. Y. Acad. Sci.. 2006.12; 1091 76-82. ( PubMed, DOI )

  311. Shinichiro Y Koga, Satoru Kumaki, Ryo Ichinohasama, Mitsutoshi Munakata, Kazuhiro Haginoya, Yoshiyuki Ohashi, Yoshiko Tanaka, Osamu Sakamoto, Masayoshi Minegishi, Tomohiro Morio, Kazuie Iinuma, Shigeru Tsuchiya. The first infant case with hepatosplenic gammadelta T-cell lymphoma after acute disseminated encephalomyelitis (ADEM)-like exacerbation. J. Pediatr. Hematol. Oncol.. 2006.11; 28 (11): 741-745. ( PubMed, DOI )

  312. Ryoji Kobayashi, Tadashi Ariga, Shigeaki Nonoyama, Hirokazu Kanegane, Shigeru Tsuchiya, Tomohiro Morio, Hiromasa Yabe, Yoshihisa Nagatoshi, Keisei Kawa, Ken Tabuchi, Masahiro Tsuchida, Toshio Miyawaki, Shunichi Kato. Outcome in patients with Wiskott-Aldrich syndrome following stem cell transplantation: an analysis of 57 patients in Japan. Br. J. Haematol.. 2006.11; 135 (3): 362-366. ( PubMed, DOI )

  313. Yoshiyuki Minegishi, Masako Saito, Tomohiro Morio, Ken Watanabe, Kazunaga Agematsu, Shigeru Tsuchiya, Hidetoshi Takada, Toshiro Hara, Nobuaki Kawamura, Tadashi Ariga, Hideo Kaneko, Naomi Kondo, Ikuya Tsuge, Akihiro Yachie, Yukio Sakiyama, Tsutomu Iwata, Fumio Bessho, Tsutomu Ohishi, Kosuke Joh, Kohsuke Imai, Kazuhiro Kogawa, Miwa Shinohara, Mikiya Fujieda, Hiroshi Wakiguchi, Srdjan Pasic, Mario Abinun, Hans D Ochs, Eleonore D Renner, Annette Jansson, Bernd H Belohradsky, Ayse Metin, Norio Shimizu, Shuki Mizutani, Toshio Miyawaki, Shigeaki Nonoyama, Hajime Karasuyama. Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity. 2006.11; 25 (5): 745-755. ( PubMed, DOI )

  314. Masahiko Kato, Hirokazu Kimura, Mitsuru Seki, Akira Shimada, Yasuhide Hayashi, Tomohiro Morio, Satoru Kumaki, Yasushi Ishida, Yoshiro Kamachi, Akihiro Yachie. Omenn syndrome--review of several phenotypes of Omenn syndrome and RAG1/RAG2 mutations in Japan. Allergol Int. 2006.06; 55 (2): 115-119. ( PubMed, DOI )

  315. Masayuki Nagasawa, Takeshi Isoda, Sukeyuki Itoh, Michiko Kajiwara, Tomohiro Morio, Norio Shimizu, Kazuyuki Ogawa, Kinya Nagata, Masataka Nakamura, Shuki Mizutani. Analysis of serum granulysin in patients with hematopoietic stem-cell transplantation: its usefulness as a marker of graft-versus-host reaction. Am. J. Hematol.. 2006.05; 81 (5): 340-348. ( PubMed, DOI )

  316. Kohsuke Imai, Mitsunobu Shimadzu, Takeo Kubota, Tomohiro Morio, Takeshi Matsunaga, Young-Dong Park, Akira Yoshioka, Shigeaki Nonoyama. Female hyper IgM syndrome type 1 with a chromosomal translocation disrupting CD40LG. Biochim. Biophys. Acta. 2006.03; 1762 (3): 335-340. ( PubMed, DOI )

  317. Y Tsuji, K Imai, M Kajiwara, Y Aoki, T Isoda, D Tomizawa, M Imai, S Ito, H Maeda, Y Minegishi, H Ohkawa, J Yata, N Sasaki, K Kogawa, M Nagasawa, T Morio, S Nonoyama, S Mizutani. Hematopoietic stem cell transplantation for 30 patients with primary immunodeficiency diseases: 20 years experience of a single team. Bone Marrow Transplant.. 2006.03; 37 (5): 469-477. ( PubMed, DOI )

  318. Jae-Ho Chang, Soo-Ki Kim, In-Hong Choi, Sang-Kyou Lee, Tomohiro Morio, Eun-Ju Chang. Apoptosis of macrophages induced by Trichomonas vaginalis through the phosphorylation of p38 mitogen-activated protein kinase that locates at downstream of mitochondria-dependent caspase activation. Int. J. Biochem. Cell Biol.. 2006; 38 (4): 638-647. ( PubMed, DOI )

  319. Daisuke Tomizawa, Yuki Aoki, Masayuki Nagasawa, Tomohiro Morio, Michiko Kajiwara, Teruaki Sekine, Norio Shimizu, Masahiko Kato, Akihiro Yachie, Shuki Mizutani. Novel adopted immunotherapy for mixed chimerism after unrelated cord blood transplantation in Omenn syndrome. Eur. J. Haematol.. 2005.11; 75 (5): 441-444. ( PubMed, DOI )

  320. Ji Hoon Yu, Joo Weon Lim, Kyung Hwan Kim, Tomohiro Morio, Hyeyoung Kim. NADPH oxidase and apoptosis in cerulein-stimulated pancreatic acinar AR42J cells. Free Radic. Biol. Med.. 2005.09; 39 (5): 590-602. ( PubMed, DOI )

  321. Yoichiro Tsuji, Sukeyuki Ito, Takeshi Isoda, Michiko Kajiwara, Masayuki Nagasawa, Tomohiro Morio, Shuki Mizutani. Successful nonmyeloablative cord blood transplantation for an infant with malignant infantile osteopetrosis. J. Pediatr. Hematol. Oncol.. 2005.09; 27 (9): 495-498. ( PubMed )

  322. Motohiko Okano, Keisei Kawa, Hiroshi Kimura, Akihiro Yachie, Hiroshi Wakiguchi, Akihiko Maeda, Shosuke Imai, Shouichi Ohga, Hirokazu Kanegane, Shigeru Tsuchiya, Tomohiro Morio, Masaaki Mori, Shumpei Yokota, Shinsaku Imashuku. Proposed guidelines for diagnosing chronic active Epstein-Barr virus infection. Am. J. Hematol.. 2005.09; 80 (1): 64-69. ( PubMed, DOI )

  323. Kohsuke Imai, Yi Zhu, Patrick Revy, Tomohiro Morio, Shuki Mizutani, Alain Fischer, Shigeaki Nonoyama, Anne Durandy. Analysis of class switch recombination and somatic hypermutation in patients affected with autosomal dominant hyper-IgM syndrome type 2. Clin. Immunol.. 2005.06; 115 (3): 277-285. ( PubMed, DOI )

  324. Ling Chen, Tomohiro Morio, Yoshiyuki Minegishi, Shin-Ichiro Nakada, Masayuki Nagasawa, Kenshi Komatsu, Luciana Chessa, Anna Villa, Daniele Lecis, Domenico Delia, Shuki Mizutani. Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage. Cancer Sci.. 2005.02; 96 (2): 134-141. ( PubMed, DOI )

  325. Masayuki Nagasawa, Yi Zhu, Takeshi Isoda, Daisuke Tomizawa, Sukeyuki Itoh, Michiko Kajiwara, Tomohiro Morio, Shigeaki Nonoyama, Norio Shimizu, Shuki Mizutani. Analysis of serum soluble CD40 ligand (sCD40L) in the patients undergoing allogeneic stem cell transplantation: platelet is a major source of serum sCD40L. Eur. J. Haematol.. 2005.01; 74 (1): 54-60. ( PubMed, DOI )

  326. Yoshikazu Ohtsuka, Toshiaki Shimizu, Kyoko Nishizawa, Risako Ohtaki, Tomonosuke Someya, Atsuko Noguchi, Naoto Shimura, Hyoiru Kim, Harunori Sugimoto, Hiroo Fujita, Tomohiro Morio, Yuichiro Yamashiro. Successful engraftment and decrease of cytomegalovirus load after cord blood stem cell transplantation in a patient with DiGeorge syndrome. Eur. J. Pediatr.. 2004.12; 163 (12): 747-748. ( PubMed, DOI )

  327. Jae-Ho Chang, Yong-Suk Ryang, Tomohiro Morio, Sang-Kyou Lee, Eun-Ju Chang. Trichomonas vaginalis inhibits proinflammatory cytokine production in macrophages by suppressing NF-kappaB activation. Mol. Cells. 2004.10; 18 (2): 177-185. ( PubMed )

  328. Wook-Jin Chae, Heung-Kyu Lee, Jin-Hwan Han, Sang-Won Vincent Kim, Alfred L M Bothwell, Tomohiro Morio, Sang-Kyou Lee. Qualitatively differential regulation of T cell activation and apoptosis by T cell receptor zeta chain ITAMs and their tyrosine residues. Int. Immunol.. 2004.09; 16 (9): 1225-1236. ( PubMed, DOI )

  329. Daisuke Tomizawa, Kohsuke Imai, Sukeyuki Ito, Michiko Kajiwara, Yoshiyuki Minegishi, Masayuki Nagasawa, Tomohiro Morio, Shigeaki Nonoyama, Shuki Mizutani. Allogeneic hematopoietic stem cell transplantation for seven children with X-linked hyper-IgM syndrome: a single center experience. Am. J. Hematol.. 2004.05; 76 (1): 33-39. ( PubMed, DOI )

  330. Masayuki Nagasawa, Daisuke Tomizawa, Youichirou Tsuji, Michiko Kajiwara, Tomohiro Morio, Shigeaki Nonoyama, Minoru Asada, Shuki Mizutani. Pancytopenia presenting with monosomy 7 which disappeared after immunosuppressive therapy. Leuk. Res.. 2004.03; 28 (3): 315-319. ( PubMed )

  331. Noriko Shimasaki, Tetsuya Mori, Hiroyuki Shimada, Mayumi Sugita, Masataka Higuchi, Makio Mukai, Tomohiro Morio, Shinichiro Okamoto. Epstein-Barr virus-associated posttransplant lymphoproliferative disorder after a cord blood stem cell transplantation presenting with pulmonary nodules. J. Pediatr. Hematol. Oncol.. 2004.02; 26 (2): 124-127. ( PubMed )

  332. Masayuki Nagasawa, Sukeyuki Itoh, Yasuyuki Sawada, Tomohiro Morio, Shigeaki Nonoyama, Shuki Mizutani. Coagulopathy in a patient with X-linked hyper-IgM syndrome who developed Kaposi's sarcoma. Am. J. Hematol.. 2004.02; 75 (2): 116-117. ( PubMed, DOI )

  333. Kohsuke Imai, Tomohiro Morio, Yi Zhu, Yinzhu Jin, Sukeyuki Itoh, Michiko Kajiwara, Jun-Ichi Yata, Shuki Mizutani, Hans D Ochs, Shigeaki Nonoyama. Clinical course of patients with WASP gene mutations. Blood. 2004.01; 103 (2): 456-464. ( PubMed, DOI )

  334. Ji Yeon Song, Joo Weon Lim, Hyeyoung Kim, Tomohiro Morio, Kyung Hwan Kim. Oxidative stress induces nuclear loss of DNA repair proteins Ku70 and Ku80 and apoptosis in pancreatic acinar AR42J cells. J. Biol. Chem.. 2003.09; 278 (38): 36676-36687. ( PubMed, DOI )

  335. Masako Imai, Shuki Mizutani, Tomohiro Morio. Coordinated regulation of the promoter and enhancer regions of human CD23 gene by signal through IL-4R and CD40, and the role of Ku70/80 in the enhancer activity. J. Med. Dent. Sci.. 2003.06; 50 (2): 155-165. ( PubMed )

  336. Yu Zhang, Hiroshi Nagata, Tatsuro Ikeuchi, Hiroyuki Mukai, Michiko K Oyoshi, Ayako Demachi, Tomohiro Morio, Hiroshi Wakiguchi, Nobuhiro Kimura, Norio Shimizu, Kohtaro Yamamoto. Common cytological and cytogenetic features of Epstein-Barr virus (EBV)-positive natural killer (NK) cells and cell lines derived from patients with nasal T/NK-cell lymphomas, chronic active EBV infection and hydroa vacciniforme-like eruptions. Br. J. Haematol.. 2003.06; 121 (5): 805-814. ( PubMed )

  337. Michiko K Oyoshi, Hiroshi Nagata, Nobuhiro Kimura, Yu Zhang, Ayako Demachi, Toshiro Hara, Hirokazu Kanegane, Yoshinobu Matsuo, Tomohiro Yamaguchi, Tomohiro Morio, Atsuyoshi Hirano, Norio Shimizu, Kohtaro Yamamoto. Preferential Expansion of Vγ9-JγP/Vδ2-Jδ3 γδ T Cells in Nasal T-Cell Lymphoma and Chronic Active Epstein-Barr Virus Infection. Am. J. Pathol.. 2003.05; 162 (5): 1629-1638. ( PubMed )

  338. Yi Zhu, Shigeaki Nonoyama, Tomohiro Morio, Masamichi Muramatsu, Tasuku Honjo, Shuki Mizutani. Type two hyper-IgM syndrome caused by mutation in activation-induced cytidine deaminase. J. Med. Dent. Sci.. 2003.03; 50 (1): 41-46. ( PubMed )

  339. Hiroshi Kimura, Tsuneo Morishima, Hirokazu Kanegane, Shouichi Ohga, Yo Hoshino, Akihiko Maeda, Shosuke Imai, Motohiko Okano, Tomohiro Morio, Shumpei Yokota, Shigeru Tsuchiya, Akihiro Yachie, Shinsaku Imashuku, Keisei Kawa, Hiroshi Wakiguchi, . Prognostic factors for chronic active Epstein-Barr virus infection. J. Infect. Dis.. 2003.02; 187 (4): 527-533. ( PubMed, DOI )

  340. Ayako Demachi, Hiroshi Nagata, Tomohiro Morio, Michiko K Oyoshi, Yu Zhang, Nobuko Tabata, Nobuhiro Kimura, Norio Shimizu, Kohtaro Yamamoto. Characterization of Epstein-Barr virus (EBV)-positive NK cells isolated from hydroa vacciniforme-like eruptions. Microbiol. Immunol.. 2003; 47 (7): 543-552. ( PubMed )

  341. Jae-Hyuck Shim, Heung-Kyu Lee, Eun-Ju Chang, Wook-Jin Chae, Jin-Hwan Han, Duck-Jong Han, Tomohiro Morio, Jung-Jin Yang, Alfred Bothwell, Sang-Kyou Lee. Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction. Proc. Natl. Acad. Sci. U.S.A.. 2002.08; 99 (16): 10617-10622. ( PubMed, DOI )

  342. Y Jin, S Nonoyama, T Morio, K Imai, H D Ochs, S Mizutani. Characterization of soluble CD40 ligand released from human activated platelets. J. Med. Dent. Sci.. 2001.03; 48 (1): 23-27. ( PubMed )

  343. S Kumaki, N Ishii, M Minegishi, Y Ohashi, I Hakozaki, S Nonoyama, K Imai, T Morio, I Tsuge, Y Sakiyama, A Miyanoshita, J Miura, M Mayumi, T Heike, K Katamura, H Takada, I Izumi, J Kamizono, S Hibi, H Sasaki, M Kimura, A Kikuta, Y Date, M Sako, H Tanaka, K Sano, K Sugamura, S Tsuchiya. Characterization of the gammac chain among 27 unrelated Japanese patients with X-linked severe combined immunodeficiency (X-SCID). Hum. Genet.. 2000.10; 107 (4): 406-408. ( PubMed )

  344. M Nagasawa, M Imai, K Imai, S Itoh, M Kajiwara, T Morio, S Nonoyama. In vivo class switch of B cells after cord blood stem cell transplantation in severe combined immune deficient (SCID) patient. Am. J. Hematol.. 2000.10; 65 (2): 176-177. ( PubMed )

  345. S Itoh, S Nonoyama, T Morio, K Imai, H Okawa, H D Ochs, M Shimadzu, J Yata. Mutations of the WASP gene in 10 Japanese patients with Wiskott-Aldrich syndrome and X-linked thrombocytopenia. Int. J. Hematol.. 2000.01; 71 (1): 79-83. ( PubMed )

  346. M Kajiwara, S Nonoyama, M Eguchi, T Morio, K Imai, H Okawa, M Kaneko, M Sako, S Ohga, M Maeda, S Hibi, H Hashimito, A Shibuya, H D Ochs, T Nakahata, J I Yata. WASP is involved in proliferation and differentiation of human haemopoietic progenitors in vitro. Br. J. Haematol.. 1999.11; 107 (2): 254-262. ( PubMed )

  347. T Morio, S H Hanissian, L B Bacharier, H Teraoka, S Nonoyama, M Seki, J Kondo, H Nakano, S K Lee, R S Geha, J Yata. Ku in the cytoplasm associates with CD40 in human B cells and translocates into the nucleus following incubation with IL-4 and anti-CD40 mAb. Immunity. 1999.09; 11 (3): 339-348. ( PubMed )

  348. K Imai, S Nonoyama, H Miki, T Morio, K Fukami, Q Zhu, A Aruffo, H D Ochs, J Yata, T Takenawa. The pleckstrin homology domain of the Wiskott-Aldrich syndrome protein is involved in the organization of actin cytoskeleton. Clin. Immunol.. 1999.08; 92 (2): 128-137. ( PubMed, DOI )

  349. S Nonoyama, S Tsukada, T Yamadori, T Miyawaki, Y Z Jin, C Watanabe, T Morio, J Yata, H D Ochs. Functional analysis of peripheral blood B cells in patients with X-linked agammaglobulinemia. J. Immunol.. 1998.10; 161 (8): 3925-3929. ( PubMed )

  350. T Morio, T Chatila, R S Geha. HIV glycoprotein gp120 inhibits TCR-CD3-mediated activation of fyn and lck. Int. Immunol.. 1997.01; 9 (1): 53-64. ( PubMed )

  351. K Kawabata, M Nagasawa, T Morio, H Okawa, J Yata. Decreased alpha/beta heterodimer among CD8 molecules of peripheral blood T cells in Wiskott-Aldrich syndrome. Clin. Immunol. Immunopathol.. 1996.11; 81 (2): 129-135. ( PubMed )

  352. T Morio, S Hanissian, R S Geha. Characterization of a 23-kDa protein associated with CD40. Proc. Natl. Acad. Sci. U.S.A.. 1995.12; 92 (25): 11633-11636. ( PubMed )

  353. T Kondoh, K Hayashi, T Matsumoto, M Yoshimoto, T Morio, J Yata, Y Tsuji. Two sisters with clinical diagnosis of Wiskott-Aldrich syndrome: is the condition in the family autosomal recessive? Am. J. Med. Genet.. 1995.10; 60 (5): 364-369. ( PubMed, DOI )

  354. N Ramesh, T Morio, R Fuleihan, M Worm, A Horner, E Tsitsikov, E Castigli, R S Geha. CD40-CD40 ligand (CD40L) interactions and X-linked hyperIgM syndrome (HIGMX-1). Clin. Immunol. Immunopathol.. 1995.09; 76 (3 Pt 2): S208-S213. ( PubMed )

  355. Y Mizuno, T Morio, T Hara. Peripheral expansion of V delta 1-J delta 1/J delta 2+ gamma delta T cells and large granular lymphocytes in a patient with Wiskott-Aldrich syndrome. Acta Paediatr Jpn. 1995.06; 37 (3): 394-398. ( PubMed )

  356. M Nagasawa, T Morio, S Takagi, J Yata. Differences of LAK-activity and IL-2 responsiveness between alpha/beta and gamma/delta T cells which developed after thymus transplantation. Acta Paediatr Jpn. 1994.08; 36 (4): 396-403. ( PubMed )

  357. T Morio, R S Geha, T A Chatila. Engagement of MHC class II molecules by staphylococcal superantigens activates src-type protein tyrosine kinases. Eur. J. Immunol.. 1994.03; 24 (3): 651-658. ( PubMed, DOI )

  358. C L Ren, T Morio, S M Fu, R S Geha. Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase Cγ2. J. Exp. Med.. 1994.02; 179 (2): 673-680. ( PubMed )

  359. N S Trede, T Morio, P R Scholl, R S Geha, T Chatila. Early activation events induced by the staphylococcal superantigen toxic shock syndrome toxin-1 in human peripheral blood monocytes. Clin. Immunol. Immunopathol.. 1994.02; 70 (2): 137-144. ( PubMed )

  360. H Hamaguchi, Y Nakamura, K Nagata, S Shiba, H Arimura, K Muroga, S Miyake, Y Ohkawa, T Morio. Philadelphia-chromosome-positive, monosomy 7 biphenotypic acute mixed lineage leukemia in adults: a pluripotent stem cell disorder. Leukemia. 1993.11; 7 (11): 1752-1758. ( PubMed )

  361. H Okawa, M Nagasawa, T Morio, K Takase, K Tanaka, J Yata, K Dan, T Nomura, H Sakamaki, Y Onozawa. Peroxidase-negative and myelomonocytic antigen-positive acute leukemia. Int. J. Hematol.. 1992.04; 55 (2): 165-171. ( PubMed )

  362. T Chatila, P Scholl, N Ramesh, N Trede, R Fuleihan, T Morio, R S Geha. Cellular and molecular mechanisms of immune activation by microbial superantigens: studies using toxic shock syndrome toxin-1. Chem. Immunol.. 1992; 55 146-171. ( PubMed )

  363. T Morio, M Nagasawa, J Yata. Gamma-delta T cells in patients with primary immunodeficiency syndrome: their function and a possible role in the pathogenesis. Chem. Immunol.. 1992; 53 102-120. ( PubMed )

  364. T Suzuki, M Bessho, K Hirashima, S Tohda, K Nagata, T Morio, Y Imai, N Nara. Enhancement by transforming growth factor-beta 1 (TGF-beta 1) of the proliferation of leukemic blast progenitors stimulated with IL-3. J. Cell. Physiol.. 1991.09; 148 (3): 396-403. ( PubMed, DOI )

  365. M Nagasawa, T Morio, S Takagi, J Yata. Generation and function of γδ T cells after allogeneic bone marrow transplantation in humans: comparison in absence or presence of HLA-matched or mismatched thymus. Acta Paediatr Jpn. 1991.04; 33 (2): 146-158. ( PubMed )

  366. T Suzuki, T Morio, S Tohda, K Nagata, Y Yamashita, Y Imai, N Aoki, K Hirashima, N Nara. Effects of interleukin-6 and granulocyte colony-stimulating factor on the proliferation of leukemic blast progenitors from acute myeloblastic leukemia patients. Jpn. J. Cancer Res.. 1990.10; 81 (10): 979-986. ( PubMed )

  367. S Tohda, T Morio, T Suzuki, K Nagata, T Kamiyama, Y Imai, N Nara, N Aoki. Richter syndrome with two B cell clones possessing different surface immunoglobulins and immunoglobulin gene rearrangements. Am. J. Hematol.. 1990.09; 35 (1): 32-36. ( PubMed )

  368. T Morio, M Nagasawa, S Nonoyama, H Okawa, J Yata. Phenotypic profile and functions of T cell receptor-γδ-bearing cells from patients with primary immunodeficiency syndrome. J. Immunol.. 1990.02; 144 (4): 1270-1275. ( PubMed )

  369. N Nara, T Suzuki, K Nagata, S Tohda, Y Yamashita, Y Nakamura, Y Imai, T Morio, M Minamihisamatsu. Granulocyte colony-stimulating factor-dependent growth of an acute myeloblastic leukemia cell line. Jpn. J. Cancer Res.. 1990; 81 (6-7): 625-631. ( PubMed )

  370. N Nara, S Tohda, T Suzuki, K Nagata, Y Yamashita, Y Imai, T Morio, M Bessho, A Shibuya, Y Adachi. Terminal differentiation to mature neutrophils and eosinophils in suspension culture of the blast progenitors in acute myeloblastic leukemia. Hematol Pathol. 1990; 4 (3): 125-134. ( PubMed )

  371. T Morio, S Nonoyama, J Yata. Suppression of in vitro immunoglobulin synthesis by CD16(Leu11a)+ CD56 (NKH1,Leu19)+non-T lineage NK cells; lack of suppression of cells from immunodeficient patients. Clin. Exp. Immunol.. 1989.11; 78 (2): 159-165. ( PubMed )

  372. T Morio, K Takase, H Okawa, M Oguchi, M Kanbara, F Hiruma, K Yoshino, T Kaneko, S Asamura, T Inoue. The increase of non-MHC-restricted cytotoxic cells (γδ-TCR-bearing T cells or NK cells) and the abnormal differentiation of B cells in Wiskott-Aldrich syndrome. Clin. Immunol. Immunopathol.. 1989.08; 52 (2): 279-290. ( PubMed )

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Conference Activities & Talks 【 display / non-display

  1. 森尾友宏. 医療情報の社会還元に向けた東京医科歯科大の取り組み. 令和4年度medU-net年次総会・シンポジウム 2022.06.20 WEB開催

  2. Masatoshi Takagi, Chitose Ogawa, Tomoko Iehara, Yuki Aoki-Nogami, Eri Isibashi, Minoru Imai, Toshimi Kimura, Masashi Nagata, Masato Yasuhara, Mitsuko Masutani, Kenichi Yoshimura, Daisuke Tomizawa, Atsushi Ogawa, Kan Yonemori, Tetsuro Kihara, Kiyoshi Nobori, Kazuhisa Hasebe, Shuki Mizutani, Tomohiro Morio, Hajime Hosoi, Ryuji Koike. First In Children Phase I Clinical Study Of Oral Olaparib In Pediatric Patients With Refractory Solid Tumors. SIOP2021 2021.10.24 Honolulu(Web)

  3. Imanaka Y, Taniguchi M, Doi T, Shimomura M, Tsumura M, Karakawa S, Imai K, Morio T, Puel A, Casanova JL, Ohara O, Kamei K, Kobayashi M, Okada S. Card9 deficiency in a patient with invasive infection due to exophiala dermatitidis and the asymptomatic siblings. 19th Biennial Meeting of The European Society of immunodeficiencies (ESID 2020) 2020.10.14 web

  4. Tanita K, Sakura F, Tsumura M, Ohnishi H, Hoshino A, Suzuki K, Okada S, Nambu R, Umetsu S, Imai K, Morio T, Kanegane H. Patients with the GAIN-OF-FUNCTION mutations in STAT3 present with a variety of autoimmune diseases. 19th Biennial Meeting of The European Society of immunodeficiencies (ESID 2020) 2020.10.14 web

  5. Satoshi Miyamoto , Masakatsu Yanagimachi , Katsutsugu Umeda , Akihiro Iguchi , Yoji Sasahara , Hidetoshi Takada , Masafumi Yamada , Masataka Ishimura ,Takashi Koike , Masahiro Yasui , Yoshiyuki Takahashi , Hiroshi Kawaguchi , Michiko Kajiwara , Masami Inoue , Koji Kato, Yoshiko Hashii, Yoshiko Atsuta , Hiromasa Yabe , Kohsuke Imai , Tomohiro Morio. Hematopoietic stem cell transplantation for inborn errors of immunity in Japan: overview of a nationwide retrospective analysis. 46th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT 2020 Virtual) 2020.08.29

  6. Satoshi Miyamoto, Masakatsu Yanagimachi, Katsutsugu Umeda, Akihiro Iguchi, Yoji Sasahara, Hidetoshi Takada, Yoshiyuki Takahashi, Michiko Kajiwara, Masami Inoue, Koji Kato, Yoshiko Hashii, Yoshiko Atsuta, Hiromasa Yabe, Kohsuke Imai, Tomohiro Morio. Hematopoietic stem cell transplantation for severe combined immunodeficiency in Japan: a nationwide retrospective analysis. 46th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT 2020 Virtual) 2020.08.29

  7. Mikhail A.Rojavin,Tomohiro Morio,Dandan Luo,Gautam Baheti,Jutta Hofmann,Michael A.Tortorici. INDIVIDUAL AND POPULATION-LEVEL PHARMACOKINETIC PROPERTIES OF PRIVIGEN® IN JAPANESE PATIENTS WITH PRIMARY IMMUNODEFICIENCY(PID). The 3rd Annual Scientific Meeting of the Japanese Society for Immunodeficiency and Autoinflammatory Diseases (JSIAD) 2020.02.15 Tokyo

  8. Miko Okamura, Kay Tanita, Hidetoshi Takada, Tetsuo Mitsui, Yoshiyuki Minegishi, Kohsuke Imai, Tomohiro Morio, Hirokazu Kanegane. Somatically reverted T cells in dedicator of cytokinesis 8 deficiency modify cellular immunity. 3rd Scientific Congress of Asia Pacific Society for Immunodeficiencies 2020.02.09 Chandigarh, India

  9. Takahiro Tomoda, Tsubasa Okano, Kento Inoue, Motoi Yamashita, Takahiro Kamiya, Takeshi Isoda Masakatsu Yanagimachi, Hirokazu Kanegane, Masatoshi Takagi, Tomohiro Morio, Kohsuke Imai. Second transplantation rescued the graft failure after hematopoietic stem cell transplantation. 3rd Scientific Congress of Asia Pacific Society for Immunodeficiencies 2020.02.09 Chandigarh, India.

  10. Takahiro Tomoda, Tsubasa Okano, Kento Inoue, Motoi Yamashita, Takahiro Kamiya, Takeshi Isoda, Masakatsu Yanagimachi, Hirokazu Kanegane, Masatoshi Takagi, Tomohiro Morio, Kohsuke Imai. An intractable case of hyper IgE syndrome. APSID (Asia Pacific Society for Immunodeficiencies) School cum Workshop 2020.02.06 Chandigarh, India.

  11. Haruka Hiroki, Masatoshi Takagi, Yuko Ishi, Jinhua Piao, Tomohiro Morio. PARP Inhibition Sensitize BCR-ABL1 Positive Cell. 61st American Society of Hematology (ASH) Annual Meeting and Exposition 2019.12.08 Orlando

  12. Satoshi Miyamoto, Takuya Naruto, Tomohiro Morio, Kevin Y Urayama, Atsushi Manabe, Masatoshi Takagi. Association of Germline Variants of TCF3 and PAX5 with Pediatric Acute Lymphoblastic Leukemia Development. 61st American Society of Hematology (ASH) Annual Meeting and Exposition 2019.12.07 Orlando

  13. Hoshino A, Okano T, Matsumoto K, Nishimura A, Shintaku H, Tokoro S, Okamoto H, Wada T, Mitsuiki N, Kajiwara M, Takagi M, Imai K, Kanegane H, Morio T. Plasmacytoma-Like Post-Transplant Lymphoproliferative Disorder with Multiple Autoantibodies in a XIAP Deficient Patient . 2019 Focused Meeting of the European Society of Immunodeficiencies (ESID2019) 2019.10.18 Brussels, Belgium

  14. Okano T, Imai K, Naruto T, Okada S, Okamoto K, Yamashita M, Yeh T. W, Takagi M, Kanegane H, Morio T . Diagnostic Approach by Whole Exome Sequencing for 141 Patients of Inborn Errors of Immunity . 2019 Focused Meeting of the European Society of Immunodeficiencies (ESID2019) 2019.10.18 Brussels, Belgium

  15. Sakata S, Okada S, Matsubayashi T, Tamaura M, Tsumura M, Okano T, Imai K, Bustamante J, Morio T, Casanova JL, Kobayashi M. . The First Intronic Mutations Which Caused Autosomal Recessive Complete STAT1 Deficiency . 2019 Focused Meeting of the European Society of Immunodeficiencies (ESID2019) 2019.10.18 Brussels, Belgium

  16. Takeru Yamauchi, Kei Takasawa, Yoshichika Maeda, Manabu Takahashi, Tomohiro Morio, Shun Isibashi, Kenichi Kashimada. A case of homozygous familial hypobetalipoproteinemia associated with chronic liver dysfunction. 第53回日本小児内分泌学会学術集会 2019.09.27 京都

  17. Morio T, Gotoh K, Imagawa T, Morita K, Ohnishi H, Yasui K, Hofmann J, Lawo JP, Shebl A, Rojavin MA. Safety and Tolerability of IgPro10 (PRIVIGEN®) in Japanese Patients with Primary Immunodeficiency: Data From A Phase 3 Study. 2019 Focused Meeting of the European Society of Immunodeficiencies (ESID2019) 2019.09.20 Brussels

  18. Nishimura A, Naruto T, Hoshino A, Amano K, Iwamoto S, Hirayama M, Grigg A, Bosco J J, Migita M, Takagi M, Ohara O, Morio T, van Zelm MC, Kanegane H. Genomics Analysis of Leukemia Predisposition in X-Linked Agammaglobulinemia. 2019 Focused Meeting of the European Society of Immunodeficiencies (ESID2019) 2019.09.20 Brussels

  19. Hoshino A, Okano T, Matsumoto K, Nishimura A, Shintaku H, Tokoro S, Okamoto H, Wada T, Mitsuiki N, Kajiwara M, Takagi M, Imai K, Kanegane H, Morio T. Plasmacytoma-Like Post-Transplant Lymphoproliferative Disorder with Multiple Autoantibodies in a XIAP Deficient Patient. 2019 Focused Meeting of the European Society of Immunodeficiencies (ESID2019) 2019.09.20 Brussels

  20. Morio T, Baheti G, Tortorici MA, Hofmann J, Rojavin MA. Pharmacokinetic Properties of IgPro10 in Japanese Patients with Primary Immunodeficiency. 2019 Focused Meeting of the European Society of Immunodeficiencies (ESID2019) 2019.09.20 Brussels

  21. Okano T, Imai K, Naruto T, Okada S, Okamoto K, Yamashita M, Yeh T. W, Takagi M, Kanegane H, Morio T. Diagnostic Approach by Whole Exome Sequencing for 141 Patients of Inborn Errors of Immunity. 2019 Focused Meeting of the European Society of Immunodeficiencies (ESID2019) 2019.09.19 Brussels

  22. Sakata S, Okada S, Matsubayashi T, Tamaura M, Tsumura M, Okano T, Imai K, Bustamante J, Morio T, Casanova JL, Kobayashi M. The First Intronic Mutations Which Caused Autosomal Recessive Complete STAT1 Deficiency. 2019 Focused Meeting of the European Society of Immunodeficiencies (ESID2019) 2019.09.19 Brussels

  23. Cardinez C, Miraghazadeh B, Tanita K, da Silva E, Hoshino A, Okada S, Chand R, Asano T, Tsumura M, Yoshida K, Ohnishi H, Kato Z, Yamazaki M, Okuno Y, Miyano S, Kojima S, Ogawa S, Andrews TD, Field MA, Burgio G, Morio T, Vinuesa CG, Kanegane H, Cook M. Gain-of-Function IKBKB Mutation Causes Human Combined Immune Deficiency. 2019 Focused Meeting of the European Society of Immunodeficiencies (ESID2019) 2019.09.19 Brussels

  24. Morio T. Disorders caused by a defect in IKAROS family protein. 2019 Samsung Medeikal Center Primary Immunodeficiency Symposium 2019.07.06 Seoul

  25. Morio T. Primary immunodeficiency disorders caused by a mutation in IKAROS family gene. RIKEN IMS-JSI International Symposium on Immunology 2019 2019.06.25 Tokyo

  26. Nishimura Akira, Aoki Yuki, Ishiwata Yasuyoshi, Inoue Maiko, Ichimura Takuya, Ueyama Junichi, Matsumoto Kazuaki, Inoue Kento, Hiroki Haruka, Ono Shintaro, Okano Tsubasa, Tanaka Mari, Miyamoto Satoshi, Ashiarai Miho, Miyawaki Reiji, Yamagishi Chika, Tezuka Mari, Okawa Teppei, Hoshino Akihiro, Endo Akifumi, Yasuhara Masato, Kamiya Takahiro, Mitsuiki Noriko, Ono Toshiaki, Yanagimachi Masakatsu, Isoda Takeshi, Tomizawa Daisuke, Nagasawa Masayuki, Kajiwara Michiko, Takagi Masatoshi, Mizutani Shuki, Kanegane Hirokazu, Imai Kohsuke, Morio Tomohiro. Hematopoietic cell transplantation with reduced intensity conditioning regimen using fludarabine/busulfan and fludarabine/melphalan for primary immunodeficiency diseases . The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation 2019.03.24 Frankfurt

  27. Tanita K, Cardinez C, Miraghanzadeh B, Hoshino A, Okada S, Asano T, Tsumura M, Ohnishi H, Kato Z, Morio T, Vinuesa CG, Kanegane H, Cook MC. Gain-of-function IKBKB mutation causes human combined immune deficiency. 第2回日本免疫不全・自己炎症学会総会・学術集会 2019.02.02 東京

  28. Lin HT, Kubara K, Yamazaki K, Takagi M, Naruto T, Morio T, Okumura T, Otsu M. Enhanced Selective Inhibition of KRAS Mutant Hematopoietic Progenitor Cell Expansion By MEK and Bcl-2 Inhibition . 60st American society of Hematology Annual Meeting & Exposition 2018.12.01 San Diego

  29. Isoda T, Nishimura A, Miyamoto S, Morio T, Takagi M, Murre C. Non-Coding RNA thymod transcription modulates nuclear architecture to Orchestratet-Cell fate and block T-Cell malignancies. SIOP2018 2018.11.17 Kyoto

  30. Satoshi Miyamoto, Takuya Naruto, Tomohiro Morio, Kevin Urayama, Atsushi Manabe, Masatoshi Takagi. 小児B前駆細胞性急性リンパ性白血病患者におけるTCF3のバリアント. 第60回日本小児血液・がん学会学術集会 2018.11.15 京都

  31. Okano T, Cho K, Kwamura S, Onai N, Fujii W, Kakuta S, Kanai-Azuma M, Ohteki T, Otsu M, Ariga T, Morio T. . Induced Pluripotent Stem Cell (IPSC)-Derived Macrophages Recapitulate the Pathological Features of Pulmonary Alveolar Proteinosis Caused by OAS1 Mutation.. 18th Biennial Meeting of the European Society of Immunodeficiencies (ESID2018) 2018.10.25 Lisbon

  32. Leiding J,Vogel T, Heimall J, Gignon Jadoul V, Mhaskar R, Cooper M, O`Sullivan M, Giovannini-Chami L, Thatayatikom B, Bauer C, Hamalainen S, Taskinen M, Seppanen M,Adeli M, Formankova R, Heeg M, Pozos T, Szabolcs P, Morio T, Chua I, Hague R, Hambleton S, Tangye S, Gennery A, Cunningham-Rundles C, Su H, Rao K, Milner J, Ehl S, Forbes L.. The Natural Hisory of STAT3-GOF-The Range of Clinical Manifestations and Treatment Options.. 18th Biennial Meeting of the European Society of Immunodeficiencies (ESID2018) 2018.10.25 Lisbon

  33. Yeh T. W, Okano T, Okamoto K, Yamashita M, Takashima T, Mitsuki N, Okada S, Kanegane H, Imai K, Morio T.. April Deficiency as a Cause of Common Variable Immunodeficiency. . 18th Biennial Meeting of the European Society of Immunodeficiencies (ESID2018) 2018.10.25 Lisbon

  34. Morio T, Nakajima K, Okado H.. Benzodiazepine-resistant status epilepticus in children: Alteration in GABAAR signal in children and its potential preventive measure. The World Federation of Societies of Biological Psychiatry (WFSBP). 2018.09.07 Kobe

  35. Tomohiro Morio. Overview and Updates on PID. 2018 Samsung Medeikal Center Primary Immunodeficiency Symposium 2018.07.14 Seoul,Korea

  36. Okamoto K, Shigemizu D, Okano T, Yeh TW, Takashima T, Yamashita M, Ono S, Mitsuiki N, Takagi M, Mori M, Kanegane H, Tsunoda T, Imai K, Morio T. Gwhole exome sequence analysis using the known and candidate genes for primary immunodeficiency diseases. The 2nd APSID Scientific Congress 2018.05.07 Chonquing, China

  37. Yeh TW, Okano T, Okamoto K, Yamashta M, Takashima T, Mitusiki N, Okada S, Kaneganwe H, Imai K, Morio T. APRIL deficiency a as a cause of common variable immunodeficiency. The 2nd APSID Scientific Congress 2018.05.07 Chonquing, China

  38. 中川竜一, 高澤啓, 葉姿文, 今井耕輔, 鹿島田健一, 森尾友宏. P13Kδ活性型変異により発症したと考えられる1型糖尿病の1例 . 第91回日本内分泌学会学術集会 2018.04.27 宮崎

  39. 髙澤啓, 辻敦美, 野村莉紗, 滝島茂, 和田泰格, 長崎啓祐, 伊達木澄人, 沼倉周彦, 森尾友宏, 鹿島田健一. 小児A型インスリン抵抗症の臨床像と遺伝学的背景. 第91回日本内分泌学会学術集会 2018.04.26 宮崎

  40. Tsuji-Hosokawa A, Kato T, Ogawa Y, Nomura R, Lavery R, Takasawa K, Harley V, Morio T, Takeda S, Kashimada K. SOX9 and FOXL2 Antagonistically Regulate Peptidyl Arginine Deiminase 2 (PADI2) Expression during testicular Development. 8th International Symposium on the Biology of Vertebrate Sex determination 2018.04.16 Kona

  41. Tomohiro Morio. Multi-virus specific T cell therapy for drug-resistant viral infection following hematopoietic cell transplantation. The 5th IMSUT-CGCT Symposium 2018.01.30 Tokyo

  42. 山下基, 満生紀子, 岡田賢, 井上裕三朗, 中世古知昭, Aditya K. Padhi, Kam Y Zhang, 小原收, 今井耕輔, 高木正稔, 金兼弘和, 谷内一郎, 森尾友宏. IKZF3ヘテロ結合型ミスセンス変異によるB細胞欠損症. 第1回日本免役不全・自己炎症学会総会・学術集会 2018.01.20 東京

  43. Tomohiro Morio. Molecular and cellular basis of systemic immune disease.. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.13 Miyagi

  44. Matsumoto K, Takagi M, Ishiwata Y, Aoki Y, Miyamoto S, Hoshino A, Nishimura A, Tanaka M, Yanagimachi M, Mitsuiki N, Imai K, Kanegnane H, Kajiwara M, Takikawa K, Mae T, Tomiota O, Fujimura J, Yasuhara M, Tomizawa D, Mizutani S, Morio T. HLA haploidentical HCT using clofarabine and busulfan for refractory pediatric leukemia. JSH 2017 2017.10.20 Tokyo

  45. Morio T. Investigational Gene Analysis for Primary Immunodeficiency Diseases. Asia Pacific Society for Immunodeficiencies(APSID) 2017.10.10 Hong Kong

  46. Morio T. Hematopoietic Cell Transplantation for Primary Immunodeficiency Diseases.: Current Situation and Future Direction. Asia Pacific Society for Immunodeficiencies(APSID) 2017.10.10 Hong Kong

  47. Yamashita M, Mitsuiki N, Inoue Y, Okada S, Padhi A.K, Zhang K.Y, Ohara O, Taniuchi I, Morio T. Heterozygous IKZF3 Mutation in Patients with B cell Deficiency. ESID 2017 2017.09.14 Edinburgh,UK

  48. Kumaki E, Ono S, Shiota M, Saito N, Kanazawa N, Ida H, Oda H, Nishikomori R, Saito M, Lin H.T, Otsu M, Morio T. Neutrophil Function in PSTPIP1 Mutations.. ESID 2017 2017.09.13 Edinburg,UK

  49. Kodawaki T, Ohnishi H, Kanegane H, Kawamoto N, Hori T, Nishimura K, Kobayashi C, Shigemura T, Ogata S, Inoue Y, Kawai T, Hiejima E, Takagi M, Imai K, Nishikomori R, Ito S, Heiki T, Ohara O, Morio T, Fukao T. A Nation-wide Survey of Haploinsufficiency of A20 Reveals the Frequent Coincidence of Autoimmunity in Japan. ESID 2017 2017.09.13 Edinburgh, UK

  50. Okano T, Imai K, Mitui-Sekinaka K, Yeh T.W, Takashima T, Kanegane H, Nonoyama S, Morio T. Combined Immunodeficiency and Progressive Lymphoproliferative Diseases of Activated P13Kγ Syndrome Rescued by Hematopoietic. ESID 2017 2017.09.12 Edinburgh, UK

  51. Ono S, Yanagimachi M, Okano T, Hoshino A, Takagi M, Imai K, Morio T, Kanegane H. Inflammatory Bowel Disease Associated with XIAP Deficiency can be cured by Hematopoietic Stem Cell Transplantation. ESID 2017 2017.09.12 Edinburgh, UK

  52. Okamoto K, Okano T, Kumaki E, Tanaka E, Ono S, Wada T, Ohnishi H, Kato Z, Nunoi N, Imai K, Kanegane H, Mori M, Morio T. A Case of Non-Pulmonary Sarcoidosis Due to Novel Hypomorphic Missense Mutation of NCF2. ESID 2017 2017.09.11 Edinburgh,UK

  53. Cell and Gene Therapy for Hematological Disorders. The 8th JSH International Symposium 2017 2017.05.01 Miyazaki, Japan

  54. Okano T, Watanabe E, Takashima T, Nishikawa T, Kawano Y, Tomoda T, Tanaka-Kubota M, Miyamoto S, Yeh T, Yamashita M, Tanaka K, Mitusiki N, Ohara O, Takagi M, Imai K, Kanegane H, Morio T.. IGG1 Gammopathy in X-SCID Caused by Maternal T and B cell Engraftment. 17th Biennial Meeting of the European Society for Immunodeficiencies 2016.09.23 Barcelona, Spain

  55. Moriya K, Tanita K, Ohnishi H, Niizuma H, Rikiishi T, Nishikomori R, Ishige T, Imai K, Kanegane H, Sasahara Y, Arakawa H, Kure S, Morio T.. I⃐B-α S32 Mutations Underly Ectodermal Dysplasia with Immunodeficiency Manifestations and Correlation with Immunological Parameters.. 17th Biennial Meeting of the European Society for Immunodeficiencies 2016.09.23 Brcelona, Spain

  56. Mitsui-Sekinaka K, Imai K, Tsujita Y, Mitsuiki N, Asano T, Sekinaka Y, Kanegane H, Yoshida K, Miyano S, Kojima S, Ogawa S, Ohara O, Okada S, Kobayashi M, Takagi M, Morio T, Nonoyama S.. Activated P13 Kinase Delta Syndrome (APDS)-Like Immunodeficiency Caused by PTEN Mutation. 17th Biennial Meeting of the European Society for Immunodeficiencies 2016.09.22 Barcelona, Spain

  57. Sekinaka Y,Mitsuiki N,Imai K,Yabe M,Mitsui-Sekinaka K,Honma K,Arai A,Yoshida K,Miyano S,Seiji K,Hira A,Takata M,Ohara O,Ogawa S,Morio T,Nonoyama S. Common Variable Immunodeficiency Caused by Fanc Mutations. 17th Biennial Meeting of the European Society for Immunodeficiencies 2016.09.22 Brcelona, Spain

  58. Leiding J,Okada S,Shcherbina A,Abinun M,Pulsipher M,Hagin D,Linemans C,Sullivan K,Bunin N,Kilic S,De La Calle-Martin O,Roiman C,Aldave J.C,Iguchi A,Imai K,Ohkawa T,Gennery A,Slatter M,Ochs H,Mori T,Torgerson T. Hematopoietic Stem cell Transplantation in Patients with Gain of Function STAT1 Mutation. 17th Biennial Meeting of the European Society for Immunodeficiencies 2016.09.22 Barcelona, Spain

  59. Hoshino A, Okada S, Yoshida K, Nishida N, Yamashita M, Okano T, Tsumura M, Nishimura S, Sakata S, Takagi M, Imai K, Miyano S, Ogawa S, Kojima S, Nonoyama S, Morio T, Kanegane H. . Abnormal Hematopoiesis and Autoimmunity in Humans with Germline IKZF1 Mutations. 17th Biennial Meeting of the European Society for Immunodeficiencies 2016.09.22 Barcelona, Spain

  60. Morio T. Cell processing facility. International regulatory endeavor towards sound development of human cell therapy products. 2015.02.18 Tokyo

  61. H. Takada, T. Takimoto, M. Ishimura, M. Urata, T. Morio, T. Hara. Wiskott-aldrich syndrome in a girl caused by heterozygous wasp mutation and extremely skewed x-chromosome inactivation:an association of non-randome x-chromosome inactivation and uniparental isodisomy 6. 16th Biennial Meeting of the European society for immunodeficiencies 2014.10.31 Prague, Czech Republic

  62. T. Wada, T. Toma, M. Yasui, M. Inoue, K. Kawa, K. Imai, T. Morio, A. Yachie. Different leaky phenotype in two siblings with x-linked severe combined immunodeficiency. 16th Biennial Meeting of the European society for immunodeficiencies 2014.10.31 Prague, Czech Republic

  63. N. Mitsuiki, X. Yang, S. Bartol, Y.Kosaka, H.Takada, K. Imai, H. Kanegane, S. Mizutani, M. Van der Burg, M. Van Zelm, O. Ohara, T. Morio. Mutations in bruton's tyrosine kinase impair IgA responses. 16th Biennial Meeting of the European society for immunodeficiencies 2014.10.30 Prague, Czech Republic

  64. K. Imai, Y. Tsujita, K. Mitsui-Sekinaka, N. Mitsuiki, T. Takashima, T. Okano, Y. Aoki, F. Kimoto, M. Inoue, F. Iwasaki, T. Kaneko, T. Waragai, H. Sano, A. Kikuta, T. Morio, S. Nonoyama. Hematopoietic stem cell transplantation for the patients with activated PI3K-delta syndrome. 16th Biennial Meeting of the European society for immunodeficiencies 2014.10.30 Prague, Czech Republic

  65. T.Takashima, Y. Tsujita, T.W.Yeh, N. Mitsuiki, H. Kanegane, S Kracker, A.Durandy, S. Nonoyama, T. Morio, K. Imai. Clinical and immunological features of patients with gain-of-function PIK3CD mutations in japan. 16th Biennial Meeting of the European society for immunodeficiencies 2014.10.30 Prague, Czech Republic

  66. L. Gamez-Diaz, D. August, N. Kanariou, S. Seneviratne, C. Speckmann, M. Seidel, M. Noriko, T. Morio, M. Jordan, P. Stepensky, B. Grimbacher. LRBA deficiency:clinical, immunologic and genetic characterization. 16th Biennial Meeting of the European society for immunodeficiencies 2014.10.30 Prague, Czech Republic

  67. Morio T, Fujita Y, Ono T, Ochiai N, Leen A.M, and Takahashi S.. Development of simplified method for generation of multivirus-specific T cells.. 2014 International Symposium and Annual Meeting of Korean Society of Microbiology and Biotechnology. 2014.06 Busan, Korea.

  68. Morio T.. Primary Immunodeficiency.. Brain Korea 21 Plus Project Seminar. 2014.05

  69. Tomohito Takimoto, Hidetoshi Takada, Masataka Ishimura, Tomohiro Morio, Toshiro Hara. A Japanese Female Case of Wiskott-Aldrich Syndrome with Skewed X-chromosome Inactivation. The 4th JSH International Symposium 2013 in EHIME 2013.05 EHIME, Japan

  70. Mari Tezuka, Kohsuke Imai, Teppei Okawa, Daisuke Tomizawa, Masatoshi Takagi, Michiko Kajiwara, Masayuki Nagasawa, Tomohiro Morio, and Shuki Mizutani. Fatal Outcome Due to Parainfluenza-3 Pneumonitis in a Patient with Atypical Complete DiGeorge Syndrome. The 4th JSH International Symposium 2013 in EHIME 2013.05 EHIME, Japan

  71. Morio T. . Cord blood transplantation for primary immunodeficiency in Japan. . AsiaCORD2013. 2013.04 Kobe,Japan.

  72. Takada H, Ishimura M, Imai K, Morio T, Kobayashi M, Nonoyama S, Hara O.. Endocrine complications in primary immunodeficiency diseases in Japan.. 第41回日本免疫学会総会・学術集会 2012.12 神戸

  73. Takimoto T, Ishimura M, Takada H, Morio T, Hara T.. A Japanses female case of Wiskott Aldrich syndrome with skewed X-Chromoseme inactivation.. 第41回日本免疫学会総会・学術集会 2012.12 神戸

  74. 長澤正之、大川哲平、遠藤明史、満生紀子、青木由貴、小野敏明、磯田健志、富澤大輔、今井耕輔、高木正稔、梶原道子、森尾友宏、水谷修紀. . Thrombomodulin-alpha improves the coagulation disorder associated transplantation-related mortality after allogeneic SCT.. 第74回日本血液学会 2012.10.21 京都

  75. Takagi M, Imai K, Nakagawa M, Morio T, Mizutani S. . The Research Front Line of Immune Thrombocytopenia Chronic immune thrombocytopenia as a disease with or without association of defined diseases in children. . 第74回日本血液学会学術集会 2012.10 京都

  76. Endou A, Ookawa T, Tomizawa D, Imai K, Takagi M, Nagasawa M, Morio T, Mizutani S. . Acute myeloid leukemia with EWSR1 split signal.. 第74回日本血液学会学術集会 2012.10 京都

  77. Morio T. . Primary Immunodeficiencies due the Defect in Signaling Molecules.. 2012 KSMCB Annual Meeting. 2012.10 Seoul, Korea.

  78. Mitsuiki N, Oshim K, Imai K, Ohara O, Morio T, Mizutani S.. Genetic Analysis For 207 Cases With Primary Immunodeficiency (PID) Consulted to A Single Center Through PID Network in JAPAN (PIDJ) in 5 Years (2007-2011).. 15th Biennial Meeting of the European Society of Immunodeficiencies (ESID2012). 2012.10 Florence, Italy.

  79. Mitsuiki N, Oshima K, Imai K, Ohara O, Morio T, Mizutani S.. Genetic analysis for 207 cases with primary immunodeficiency (PID) consulted to a single center through PID network in Japan (PIDJ) in 5 years (2007-2011).. 15th Biennial Meeting of the European Society of Immunodeficiencies (ESID2012). 2012.10 Florence, Italy.

  80. Kamae C, Nakagawa N, Sato H, Honma K, Mitsuiki N, Ohara O, Kanegane H, Pasic S, Pan-Hammarström Q, MC van Zelm, Morio T, Imai K, Nonoyama S.. Classification of common variable immunodeficiency by quantification of T cell receptor recombination excision circles (TREC) and Ig kappa-deleting recombination excision circles (KREC). . 15th Biennial Meeting of the European Society of Immunodeficiencies (ESID2012). 2012.10 Florence, Italy.

  81. Hirata O, Tsumura M, Mizoguchi Y, Okada S, Minegishi S, Morio T, Kobayashi M. . Gain-of-function mutations of STAT1 in Japanese patients with CMCD.. 15th Biennial Meeting of the European Society of Immunodeficiencies (ESID2012). 2012.10 Florence, Italy.

  82. Wada T, Muraoka M, Toma T, Shigemura T, Agematsu K, Moriuchi H, Ohara O, Morio T, Yachie A. Rapid detection of intracellular p47phox and p67phox by flow cytomery in patients with chronic granulomatous disease. . 15th Biennial Meeting of the European Society of Immunodeficiencies (ESID2012). 2012.10 Florence, Italy.

  83. Honma K, Imai K, Kamae C, Ishida H, Ito Y, Kojima S, Yokosuka T, Kanegane H, Morio T, Sasahara Y, Fujiwara T, Harigae H, Hashii Y, Ohara O, Nonoyama S.. Clinical features and immunological abnormalities of GATA2 deficiency in JAPAN. . 15th Biennial Meeting of the European Society of Immunodeficiencies (ESID2012). 2012.10 Florence, Italy.

  84. Isoda T, Takagi M, Morio T, Kawamoto H, Mizutani S.. Visualization of chromosomal translocation and early T-cell development failure in ATM deficiency.. 15th Biennial Meeting of the European Society of Immunodeficiencies (ESID2012). 2012.10 Florence, Italy.

  85. Hayase T, Morimoto A, Ikeda T, Katsube N, Kawahara Y, Fukuda T. Kasii Y, Morio T, Momoi M.. HLA-matched unrelated CBT without conditioning in a SCID patient with Artemis abnormality. . 第74回日本血液学会学術集会 2012.10 京都

  86. Sato T, Kuramitsu M, Sato-Otsubo A, Yoshida K, Toki T, Terui K, Wang R, Kanno H, Morio T, Ohga S, Ohara A, Kitoh T, Kudo K, Kojima S, Ogawa S, Hamaguchi I,. Frequent mutations in the RPS17 gene in Japanese DBA Patients.. 第74回日本血液学会学術集会 2012.10 京都

  87. Kumaki S, Sasahara Y, Kamachi Y, Muramatsu H, Morio T, Goi K, SugitaK, Urabe T, Takada H, Tsuchiya S, Hara T. . Long-term B cell function after unrelated CBT using a RIC regimen in patients with X-SCID.. 第74回日本血液学会学術集会 2012.10 京都

  88. H. Takada, M. Ishimura, T. Doi, K. Imai, Y. Sasahara, H Kanegane, R. Nishikomori, T. Morio, T. Heike, M. Kobayashi, T. Ariga, S. Tsuchiya, S. Nonoyama, T. Miyawaki, T. Hara. Nation-wide survey of patients with primary immunodeficiency diseases in japan:2008. 15th Biennial Meeting of the European Society of Immunodeficiencies (ESID2012). 2012.10 Florence, Italy.

  89. Isoda T, Takagi M, Piao J, Nakagama S, Sato M, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S.. Immune defect and visualization of chromosome 14 breaks and translocations involving TCRa/d loci during early T-cell development lacking ATM. . 17th congress of the European Hematology Association (EHA). 2012.06 Amsterdam, Netherlands.

  90. Takasawa K, Kashimada K, Ono M, Matsubara Y, Hijikata A, Katsumata N, Takagi M, Morio T, Ohara O, Mizutani S.. Two Novel Hsd3b2 Miss-Sense Mutations With Different Enzymatic Activity For Δ5 Steroids: Possible Cause For Elevated Levels Of 17-Hydroxyprogesterone (17-OHP) In 3β-Hydroxysteroid Dehydrogenase (3Β-HSD) Deficiency Patients.. ENDO 2012 (The Endocrine Society’s 94th Annual Meeting & Expo). 2012.06 Houston, Texas, USA.

  91. Motoyoshi Y, Udagawa T, Chiga M, Yoshida Y, Fujimura Y, Nagasawa M, Morio T, Mizutani S, Nagata M. . A case of atypical hemolytic uremic syndrome successfully treated with anti-C5 antibody. Continuous Professional Development program of International Pediatric Nephrology Association.. Japan-Korea The 10th Pediatric Nephrology Seminar 2012. 2012.05 Tokyo, Japan.

  92. Morio T.. An old and new regulator of ROS production in neutrophils. . Seminar of Brain Korea 21 Project for Functional Foods and Nutrigenomics. 2012.03 Seoul, Korea.

  93. Isoda T, Takagi M, Piao J, Sato M, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S. Visualization of chromosomal translocation and early T-cell development failure in ATM deficiency.. Ataxia telangiectagia workshop. 2012.02 New Delhi, INDIA.

  94. Isoda T, Takagi M, Piao J, Nakagama S, Sato M, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S.. T-Cell Development Failure At β-Selection Checkpoint and TCRα/δ Locus Break Formation Associated with Chromosome 14 Translocation in Ataxia-Telangiectagia Mutated Deficient Mice.. 53rd American society of hematology, annual meeting. 2011.12 San Diego, California, USA.

  95. Kuramitsu M, Matsubara A, Morio T, Takagi M, Toki T, Terui K, Wang R, Kanno H, Ohga S, Ohara A, Masumi A, Momose H, Mizukami T, Takizawa K, Yamaguchi K, Ogawa S, Ito E, Hamaguchi I. Extensive gene deletions in Japanese patients with Diamond Blackfan anemia.. Extensive gene deletions in Japanese patients with Diamond Blackfan anemia. . 第73回日本血液学会学術集会 2011.10 名古屋

  96. Nagasawa M, Okawa T, Endo A, Mitsuiki N, Aoki Y, Ono T, Isoda T, Tomizawa D, Takagi M, Morio T, Mizutani S, Kajiwara M, Ishiwata Y, Yasuhara M.. Retrospective PK/PD analysis of oral and intravenous busulfan in pediatric patient having SCT.. 第73回日本血液学会学術集会 2011.10 名古屋

  97. Nagasawa M, Miyatake H, Hayakawa T, Hayashi Y, Katsumoto Y, Takagi M, Morio T, Ohmori S, Mizutani S. . Analysis of dielectricity and membrane proteins of erythrocytes in patient having allogenic SCT.. 第73回日本血液学会学術集会 2011.10 名古屋

  98. Isoda T, Takagi M, Piao J, Masuda K, Ikawa T, Azuma M, Morio T, Kawamoto H, Mizutani S.. DN3 T-cell development failure in Ataxia telangiectagia (AT).. 第73回日本血液学会学術集会 2011.10 名古屋

  99. Isoda T, Ford A, Tomizawa D, Frederik van Delft, David Gonzalez De Castro, Score J, Takagi M, Morio T, Greaves M, Mizutani S. . Transmission and Ingenious Clonal Evolution of Maternal Cancer Cells in the Infant. . PAS/ASPR (Pediatric Academic Societies and Asian Society for Pediatric Research) 2011. 2011.05 Denver, Colorado, USA.

  100. Morio T. . Dissection of Common Variable immunodeficiency With Distinct Phenotype. . 2011 Pediatric Academic Societies &Asian Society for Pediatric Research Joint Meeting. 2011.04 Denver, Colorado, USA.

  101. Imai K, Mitsui K, Kajiwara M, Tomizawa D, Nagasawa M, Kogawa K, Morio T, Nonoyama S.. Retrospective analysis of stem cell transplantations for X-linked hyper-IgM syndrome. . 37th Annual Meeting of the European Group for Blood and Marrow Transplantation. 2011.04 Paris, France.

  102. Morio T.. Unrelated umbilical cord blood transplantation for patients with primary immunodeficiency in Japan. . The 52nd ASH Annual Meeting. 2010.12 Orlando, Florida, USA.

  103. Kuramitsu M, Morio T, Takagi M, Toki T, Terui K, RuNan Wang, , Masumi A, Mizukami T, Momose H, Takizawa K, Yamaguchi K, Ito E, Hamaguchi I. . New Determination Method for Extensive Gene Deletions In Diamond-Blackfan Anemia. . The 52nd ASH Annual Meeting. 2010.12 Orlando, Florida, USA.

  104. Morio T. . Btk Controls ROS Production and Apoptosis in Human Neutrophils.. XIVth meeting of the European Society for Immunodeficiencies. 2010.10 Isutanbul, Republic of Turkey.

  105. Erika Asai, Taizo Wada, Yasuhisa Sakakibara, Tomoko Toma, Takashi Shimizu, Kohsuke Imai, Shigeyuki Nonoyama, Tomohiro Morio, Yoshiro Kamachi, Osamu Ohara, Akihiro Yachie. Analysis of mutations and recombination activity in patients with rag 1/2 deficiency. XIVth meeting of the European Society for Immunodeficiencies. 2010.10 Isutanbul, Republic of Turkey.

  106. Morio T. . 臍帯血移植における免疫モニタリングとT細胞免疫療法. 第2回 韓国-日本 臍帯血移植シンポジウム 2010.09

  107. Kuramitsu M, Morio T, Takagi M, Ozeki M, Masumi A, Mizukami T, Momose H, Takizawa K, Ito E, Yamaguchi K, Hamaguchi I. . A novel method to analyze genomic copy number of Diamond Blacfan anemia responsible gene.. 第72回日本血液学会学術集会 2010.09 横浜

  108. Morio T. . PP-102-32 - Impaired CD4 and CD8 Effector Function and Decreased Memory T-cell Populations in ICOS-deficient Patients.. 14th International Congress of Immunology 2010. 2010.08 Kobe, Japan.

  109. Okamoto K, Iwai Y, Oh-hora M, Yamamoto M, Morio T, Jetten A M, Akira S, Muta T, Takayanag H.. WS/PP-014-02 - IκBζ is required for the transcriptional program in Th17 development.. 14th International Congress of Immunology 2010. 2010.08 Kobe in Japan.

  110. Motoyoshi Y, Endo A, Takagi M, Nagasawa M, Morio T, Mizutani S, Nagata M.. Thrombotic microangiopathy in allogenic bone marrow transplantation in acute leukemia.. The 15th Congress of the International Pediatric Nephrology Association. 2010.08 New York.

  111. Honda F, Ikeda Y, Takahashi1 N, Lee S, Mizutani S, Morio T.. WS/PP-034-04 - Btk controls ROS production and apoptosis in human neutrophil.. 14th International Congress of Immunology 2010. 2010.08 Kobe in Japan.

  112. Shin M J, Shim J, Lee J, Chae W, Lee H, Morio T, Park J H, Chang E, Lee S.. PP-059-37 - Functional analysis of Fas-mediated activation signaling pathways in T cells.. 14th International Congress of Immunology 2010. 2010.08 Kobe in Japan.

  113. Morio T. . Common variable immunodeficiency (CVID): Molecular basis of immunedysfunction: . The 2nd Symposium for PID in Asia. 2010.02 Chiba, Japan.

  114. Takagi M, Unno J, Kiyono T, Honda F, Teraoka H, Maeda D, Masutani M, Morio T, Mizutani S.. LA DNA Double-Strand Break Formation Induced by Replication Arrest Depend On Artemis. . 51th American Society of Hematology Annual meeting 2009. 2009.12 New Orleans.

  115. Isoda T, Ford A, Tomizawa D, van Delft FW, Gonzalez de Castro D, Mitsuiki N, Score J, Taki T, Morio T, Takagi M, Saji H, Mizutani S, Greaves M.. Loss of non-inherited maternal MHC and materno-fetal transmission of p190 type BCR-ABL leukemia.. 51st Annual Meeting of the American Society of Hematology. 2009.12 New Orleans, USA

  116. 磯田健志、高木正稔、長澤正之、森尾友宏、滝 智彦、谷脇雅史、水谷修紀. Materno-fetal transmission and loss of non-inherited maternal MHC in p190 type BCR-ABL leukemia. . 第68回日本癌学会 2009.10.02 横浜

  117. Isoda T, Mitsuiki N, Aoki Y, Tomizawa D, Takagi M, Nagasawa M, Morio T, Ochiai N, Taki T, Taniwaki M, Saji H, Mizutani S.. Loss of NIMA as a possible role of materno-fetal transmission of p190 type BCR-ABL leukemia.. 第71回日本血液学会 2009.10 京都

  118. Aoki Y, Mitsuiki N, Endo A, Ono T, Takagi M, Kajiwara M, Nagasawa M, Morio T, Mizutani S, Imadome K. . A case of SLE 10years following cord blood transplantation for JMML with mixed chimerism. . 第71回日本血液学会 2009.10 京都

  119. Morio T. . ROS induced DNA damage response. Symposium: “ROS and NO”. The 46th Meeting of Korean Society of Biochemistry and Molecular Biology. 2009.05 Seoul, Korea.

  120. Tanaka E,Mukai J, Morio T, Mizutani S.. A case of Wiskott-Aldrich syndrome with purpura nephritis: Improvement in renal pathology after immunosuppressants and bone marrow transplantation.. 7th Japan-Korean pediatric nephrology seminar. 2009.04 Kyunggi-Do, Korea.

  121. Isoda T, Mitsuiki N, Aoki Y, Tomizawa D, Takagi M, Kajiwara M, Nagasawa M, Ochiai H, Taki T, Morio T, Mizutani S. An eleven-month-old girl who developed malignant lymphoma derived from maternal BCR-ABL positive clone.. 第11回乳児白血病講演会 2008.04.19 東京

  122. Morio T. . Ataxia telangiectasia: Involvement of ATM in immunodeficiency and leukemogenesis.. International symposium on Recent Advances in Cell Function and Defense Mechanisim. 2008.04 Seoul, Korea.

  123. Nakamura K, Morio T, Mizutani S,. Identification of Novel Mutation in Japanese Patients with Ataxia Telangiectasia ; Absence of Founder Mutations.. Ataxia- TelangiectasiaWorkshop 2008. 2008.04 Otsu, Shiga,

  124. Unno J, Takagi M, Watanabe F, Sato M, Takahashi N, Morio T, Teraoka H, Mizutani S. . Generation of DNA double-stranded breaks in stalled DNA replication forks: an essential step initiated by Artemis toward a second wave of DNA damage response and ATM activation.. Ataxia-Telangiectasia Workshop 2008. 2008.04 Otsu, Shiga,

  125. Watanabe F, Morio T, Ogigami N, Kiyono T, Delia D, Mizutani S.. Stability of Artemis protein is regulated by Hsp72. . Ataxia-Telangiectasia Workshop 2008. 2008.04 Otsu, Shiga,

  126. Mizutani S, Unno J, Watanabe F, Takagi M ,Morio T, Teraoka H, Domenico D.. Regulation of Artemis/ATM-related DNA damage response network.. Ataxia-Telangiectasia Workshop 2008. 2008.04 Otsu, Shiga,

  127. Morio T. . Ataxia-Telangiectasia in Japan:Phenotypic variations in affected siblings with Ataxia-Telangiectasia. . Ataxia-Telangiectasia Workshop 2008. 2008.04 Otsu, Shiga

  128. Morio T. . Immunodefiencies with impaired DNA damage response.. Recent Advances in DNA Damage Response. 2008.04

  129. Morio T. . Strategy to combat opportunistic infections after umbilical cord stem cell transplantation.. The 5th Annual International Umbilical Cord Blood Transplantation Symposium. 2007.05 California, USA.

  130. Morio T. . Immunity & Nutrition, Its importance in post-transplantation period.. Symposium on Infection, Immunity and Nutrition. 2007.03 Seoul, Korea

  131. Morio T. . Strategy to combat opportunistic infections aft Seoul, Korea.er stem cell transplantation. . The 11th Congress of Asian-Pacific Bone Marrow Transplantation. 2006.10 Nagoya, Japan.

  132. Morio T. . Cell cycle checkpoint. DNA repair system. and Carcinogenesis. . International Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis. in Commemoration of 120th Anniversary of Yonsei Univeisity. College of Medicine. 2005.06 Seoul, Korea.

  133. Morio T. . Activated T-Cell Transfusion for Opportunistic Infection in Immunodeficient Patients and for Post-transplant Infections.. The 2nd International Symposium "New Challenges in the Post Genome Era 2003" 2003.11 Seoul, Korea.

  134. Morio T. . Activated T-Cell transfusion for opportunistic infection in immunodeficient patients and for post-transplant infections.. The 10th Meeting of Transplantation/ Immunoregulation 21. 2003.11 Tokyo, Japan.

  135. Morio T. . Activated T-Cell Transfusion for Opportunistic Infection in Immunodeficient Patients.. Nihon University School of Medicine Symposium “Cell Biology of Virus Infection” 2003.10 Tokyo, Japan.

  136. Morio T. . Molecular Basis of Primary Immunodeficiency.. The 46th Meeting of Korean Association of Immunobiologists 2003.04 Seoul, Korea.

  137. Morio T. . Ku70/80, A DNA Repair Protein Involved in Cellular Survival, Transformation, and Death.. 2002 International Symposium on Exocrine Pancreas 2002.08 Seoul, Korea.

  138. Morio T. . Proteomics approach for elucidating signal transduction pathway. Symposium: "Genomics and Proteomics in Pharmacology" . Annual Meeting of Korean Society of Pharmacology 2001.04 Seoul, Korea.

  139. Morio T. . Proteomics approach for elucidating signal transduction pathway. Symposium: "Genomics and Proteomics in Pharmacology". Annual Meeting of Korean Society of Pharmacology 2001.04 Seoul, Korea.

  140. Morio T. . Identification of CD40-associated protein by protein microsequencing and ESI-MS.. In Proteomics and Genomics in Biotechnology, The 8th Bioproduct Research Center International Symposium. 2000.06 Seoul, Korea.

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Awards & Honors 【 display / non-display

  • 8th JSI Human Immunology Research Award Winner,2021.12