Personnel Information

写真a

TOHDA Shuji


Job title

Professor

Birth date

1959

Laboratory Address

5-45, Yushima 1 chome, Bunkyo-ku, Tokyo 113-8519, Japan

Laboratory Phone number

+81-3-5803-5334

Laboratory Fax number

+81-3-5803+5629

Mail Address

tohda.mlab@tmd.ac.jp

Research Areas, Keywords

Laboratory medicine, Molecular diagnostic test, Cellular biology of leukemia, Hematology, Clinical microbiology

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Medicine, School of Medicine, 1984, Graduated

Degree 【 display / non-display

  • Doctor of Medicine, Tokyo Medical and Dental University

Campus Career 【 display / non-display

  • 2015.09
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Comprehensive Patient Care, Laboratory Medicine, Professor
  • 1987.07
    -
    1987.12
    Tokyo Medical and Dental University, Medical Hospital, Senior Resident
  • 1988.07
    -
    1990.09
    Tokyo Medical and Dental University, Medical Hospital, Senior Resident
  • 1993.01
    -
    1993.03
    Tokyo Medical and Dental University, Medical Hospital, Senior Resident
  • 1996.03
    -
    1999.03
    Tokyo Medical and Dental University, Faculty of Medicine, School of Medicine, Junior Associate Professor
  • 2007.04
    -
    2015.09
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Comprehensive Patient Care, Laboratory Medicine, Associate Professor
  • 2015.10
    -
    Now
    Tokyo Medical and Dental University, Medical Hospital, Central Clinical Facilities, Clinical Laboratory, Director
  • 2019.05
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Comprehensive Patient Care, Laboratory Medicine, Professor

▼display all

Academic Society Affiliations 【 display / non-display

  • American Society of Hematology

Research Areas 【 display / non-display

  • Others

Qualification Acquired 【 display / non-display

  • Doctor

 

Published Papers & Misc 【 display / non-display

  1. Tohda S, Nara N, Murohashi I, Aoki N. Establishment of an interleukin-3-dependent leukemic cell line from a patient with chronic lymphocytic leukemia in the acute phase. Blood. 1991.10; 78 (7): 1789-1794. ( PubMed )

  2. Tohda S, Kurokawa H, Nara N. Diversity and similarity in signaling pathways of hematopoietic growth factors in human leukemia cell lines. Leukemia. 1995.05; 9 (5): 879-883. ( PubMed )

  3. Tohda S, Curtis JE, McCulloch EA, Minden MD. Comparison of the effects of all-trans and cis-retinoic acid on the blast stem cells of acute myeloblastic leukemia in culture. Leukemia. 1992.07; 6 (7): 656-661. ( PubMed )

  4. Tohda S, Minden MD, McCulloch EA. Interactions between retinoic acid and colony-stimulating factors affecting the blast cells of acute myeloblastic leukemia. Leukemia. 1991.11; 5 (11): 951-957. ( PubMed )

  5. Tohda S, Nara N, Imai Y, Aoki N. Effect of protein kinase inhibitors on the proliferation of leukemic cells stimulated by granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor or interleukin-3. Leukemia. 1991.09; 5 (9): 813-814. ( PubMed )

  6. Tohda S, Sakano S, Ohsawa M, Murakami N, Nara N. A novel cell line derived from de novo acute myeloblastic leukaemia with trilineage myelodysplasia which proliferates in response to a Notch ligand, Delta-1 protein. Br J Haematol. 2002.05; 117 (2): 373-378. ( PubMed )

  7. Tohda S, Kogoshi H, Murakami N, Sakano S, Nara N. Diverse effects of the Notch ligands Jagged1 and Delta1 on the growth and differentiation of primary acute myeloblastic leukemia cells. Exp Hematol. 2005.05; 33 (5): 558-563. ( PubMed, DOI )

  8. Tohda S. NOTCH signaling roles in acute myeloid leukemia cell growth and interaction with other stemness-related signals. Anticancer Research. 2014; 34 (11): 6259-6264. ( PubMed )

  9. Tohda S, Yang GS, Ashman LK, McCulloch EA, Minden MD. Relationship between c-Kit expression and proliferation in acute myeloblastic leukemia cell lines. J Cell Physiol. 1993.02; 154 (2): 410-418. ( PubMed, DOI )

  10. Tohda S, Sato T, Kogoshi H, Fu L, Sakano S, Nara N. Establishment of a novel B-cell lymphoma cell line with suppressed growth by gamma-secretase inhibitors. Leuk Res. 2006.11; 30 (11): 1385-1390. ( PubMed, DOI )

  11. Tohda S, Sakashita C, Fukuda T, Murakami N, Nara N. Establishment of a double Philadelphia chromosome-positive acute lymphoblastic leukemia-derived cell line, TMD5: effects of cytokines and differentiation inducers on growth of the cells. Leuk Res. 1999.03; 23 (3): 255-261. ( PubMed )

  12. Tohda S, Ohkusa T. Resolution of refractory idiopathic thrombocytopenic purpura after eradication of Helicobacter pylori. Am J Hematol. 2000.12; 65 (4): 329-330. ( PubMed )

  13. Tohda S, Nara N. Expression of Notch1 and Jagged1 proteins in acute myeloid leukemia cells. Leuk Lymphoma. 2001.07; 42 (3): 467-472. ( PubMed )

  14. Tohda S, Murata-Ohsawa M, Sakano S, Nara N. Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines. Int J Oncol. 2003.05; 22 (5): 1073-1079. ( PubMed )

  15. Tohda S, Murakami N, Nara N. Human herpesvirus 8 DNA in HIV-negative Japanese patients with multicentric Castleman's disease and related diseases. Int J Mol Med. 2001.11; 8 (5): 549-551. ( PubMed )

  16. Tohda S, Murakami N, Nara N. Polymerase chain reaction detection of rearranged immunoglobulin heavy chain DNA in plasma samples is useful in the diagnosis of B-cell lymphoma. Int J Hematol. 2000.07; 72 (1): 74-78. ( PubMed )

  17. Tohda S, Koyama N, Tanaka M, Kida Y, Murakami N, Nara N. A case of atypical chronic myeloid leukemia regarded as MDS with myeloproliferative features. Acta Haematol. 1998; 100 (4): 191-194. ( PubMed )

  18. Tohda S, Maruyama M, Nara N. Molecular typing of methicillin-resistant Staphylococcus aureus by polymerase chain reaction: distribution of the typed strains in hospitals. Intern Med. 1997.10; 36 (10): 694-699. ( PubMed )

  19. Tohda S, Nara N. Phosphorylation of signaling proteins in factor-independent myeloid leukemia cell lines. Int J Oncol. 1997.10; 11 (4): 843-847. ( PubMed )

  20. Tohda S, Kurokawa H, Nara N. Relation of protein kinase A and protein kinase C to signaling pathways of hematopoietic factors in leukemia cell lines. Int J Oncol. 1996.03; 8 (3): 521-524. ( PubMed )

  21. Tohda S, Shudo K, Minden M. The effects of retinoic Acid analogs on the blast cells of acute myeloblastic-leukemia in culture. Int J Oncol. 1994.06; 4 (6): 1311-1314. ( PubMed )

  22. Tohda S, Minden MD. Modulation of growth factor receptors on acute myeloblastic leukemia cells by retinoic acid. Jpn J Cancer Res. 1994.04; 85 (4): 378-383. ( PubMed )

  23. Tohda S, Ashman L, Minden M. The role of stroma cells on the proliferation and C-kit expression of acute myeloblastic-leukemia cells. Int J Oncol. 1993.12; 3 (6): 1141-1147. ( PubMed )

  24. Tohda S, Nara N, Tanikawa S, Imai Y, Murakami N, Aoki N. Pure red cell aplasia following autoimmune haemolytic anaemia. Cell-mediated suppression of erythropoiesis as a possible pathogenesis of pure red cell aplasia. Acta Haematol. 1992; 87 (1-2): 98-102. ( PubMed )

  25. Tohda S, Morio T, Suzuki T, Nagata K, Kamiyama T, Imai Y, Nara N, Aoki N. Richter syndrome with two B cell clones possessing different surface immunoglobulins and immunoglobulin gene rearrangements. Am J Hematol. 1990.09; 35 (1): 32-36. ( PubMed )

  26. Tohda S, Suzuki T, Nagata K, Nara N, Aoki N. Successful treatment of a patient with posthepatitic severe aplastic anemia with bolus methylprednisolone. Jpn J Med. 1990.03; 29 (2): 191-194. ( PubMed )

  27. Tohda S, Suzuki T, Nagata K, Nara N, Aoki N. Haematopoietic suppressing activity of gamma-interferon in serum and bone marrow of aplastic anaemia patients. Nippon Ketsueki Gakkai Zasshi. 1990.02; 53 (1): 14-20. ( PubMed )

  28. Tohda S, Nagata K, Suzuki T, Nara N. Comparative effects of busulfan, cytosine arabinoside and adriamycin on different maturation stages of normal human bone marrow cells. Acta Haematol. 1990; 83 (1): 16-21. ( PubMed )

  29. Takebe I, Sawabe E, Ohkusu K, Tojo N, Tohda S. Catheter-related Bloodstream Infection by Tsukamurella inchonensis in an Immunocompromised Patient. J Clin Microbiol. 2014.03; 52 (6): 2251-2253. ( PubMed, DOI )

  30. Mizuno N, Kanamori E, Saito H, Murakami N, Tojo N, Tohda S. A Case of Gray Platelet Syndrome Masked by Immune Thrombocytopenia at Presentation. Acta Haematol. 2014.02; 132 (2): 163-165. ( PubMed, DOI )

  31. Takahashi Y, Itoh M, Nara N, Tohda S. Effect of EPH-ephrin signaling on the growth of human leukemia cells. Anticancer Research. 2014; 34 2913-2918.

  32. Okuhashi Y, Itoh M, Nara N, Tohda S. NOTCH knockdown affects the proliferation and mTOR signaling of leukemia cells. Anticancer Res. 2013.10; 33 (10): 4293-4298. ( PubMed )

  33. Yonekura S, Itoh M, Okuhashi Y, Takahashi Y, Ono A, Nara N, Tohda S. Effects of the HIF1 inhibitor, echinomycin, on growth and NOTCH signalling in leukaemia cells. Anticancer Res. 2013.08; 33 (8): 3099-3103. ( PubMed )

  34. Ono A, Oike R, Okuhashi Y, Takahashi Y, Itoh M, Nara N, Tohda S. Comparative effects of PP242 and rapamycin on mTOR signalling and NOTCH signalling in leukemia cells. Anticancer Research. 2013.03; 33 (3): 809-813. ( PubMed )

  35. Kanamori E, Itoh M, Tojo N, Koyama T, Nara N, Tohda S. Flow cytometric analysis of Notch1 and Jagged1 expression in normal blood cells and leukemia cells. Exp Ther Med. 2012.09; 4 (3): 397-400. ( PubMed, DOI )

  36. Ono A, Okuhashi Y, Takahashi Y, Itoh M, Nara N, Tohda S. Advantages of the quenching probe method over other PCR-based methods for detection of the JAK2 V617F mutation. Oncol Lett. 2012.08; 4 (2): 205-208. ( PubMed, DOI )

  37. Takahashi Y, Ishigaki T, Okuhashi Y, Ono A, Itoh M, Nara N, Tohda S. Effect of BMP4 on the growth and clonogenicity of human leukemia and lymphoma cells. Anticancer Res. 2012.07; 32 (7): 2813-2817. ( PubMed )

  38. Kitamura Y, Sawabe E, Ohkusu K, Tojo N, Tohda S. First report of sepsis caused by Rhodococcus corynebacterioides in a patient with myelodysplastic syndrome. J Clin Microbiol. 2012.03; 50 (3): 1089-1091. ( PubMed, DOI )

  39. Okuhashi Y, Itoh M, Nara N, Tohda S. Effects of combination of notch inhibitor plus hedgehog inhibitor or Wnt inhibitor on growth of leukemia cells. Anticancer Res. 2011.03; 31 (3): 893-896. ( PubMed )

  40. Kawaguchi-Ihara N, Okuhashi Y, Itoh M, Murohashi I, Nara N, Tohda S. Promotion of the self-renewal capacity of human leukemia cells by sonic hedgehog protein. Anticancer Res. 2011.03; 31 (3): 781-784. ( PubMed )

  41. Okuhashi Y, Itoh M, Arai A, Nara N, Tohda S. Gamma-secretase inhibitors induce erythroid differentiation in erythroid leukemia cell lines. Anticancer Res. 2010.10; 30 (10): 4071-4074. ( PubMed )

  42. Ishigaki T, Sasaki K, Watanabe K, Nakamura N, Toyota S, Kobayashi H, Tohda S. Amplification of IGH/CCND1 fusion gene in a primary plasma cell leukemia case. Cancer Genet Cytogenet. 2010.08; 201 (1): 62-65. ( PubMed, DOI )

  43. Okuhashi Y, Nara N, Tohda S. Effects of gamma-secretase inhibitors on the growth of leukemia cells. Anticancer Res. 2010.02; 30 (2): 495-498. ( PubMed )

  44. Kawahara T, Kawaguchi-Ihara N, Okuhashi Y, Itoh M, Nara N, Tohda S. Cyclopamine and quercetin suppress the growth of leukemia and lymphoma cells. Anticancer Res. 2009.11; 29 (11): 4629-4632. ( PubMed )

  45. Fu L, Katsube K, Tohda S. Transition of cleaved Notch1 and gene expression changes in myeloblastic leukemia cells stimulated with notch ligands. Anticancer Res. 2009.10; 29 (10): 3967-3970. ( PubMed )

  46. Itoh M, Fu L, Tohda S. NF-kappaB activation induced by Notch ligand stimulation in acute myeloid leukemia cells. Oncol Rep. 2009.09; 22 (3): 631-634. ( PubMed )

  47. Kawaguchi-Ihara N, Murohashi I, Nara N, Tohda S. Promotion of the self-renewal capacity of human acute leukemia cells by Wnt3A. Anticancer Res. 2008.09; 28 (5A): 2701-2704. ( PubMed )

  48. Fu L, Nara N, Tohda S. Involvement of Notch signaling in myelodysplastic syndrome. Leuk Res. 2007.08; 31 (8): 1160-1161. ( PubMed, DOI )

  49. Kogoshi H, Sato T, Koyama T, Nara N, Tohda S. Gamma-secretase inhibitors suppress the growth of leukemia and lymphoma cells. Oncol Rep. 2007.07; 18 (1): 77-80. ( PubMed )

  50. Fu L, Kogoshi H, Nara N, Tohda S. NOTCH1 mutations are rare in acute myeloid leukemia. Leuk Lymphoma. 2006.11; 47 (11): 2400-2403. ( PubMed, DOI )

  51. Kogoshi H, Tohda S, Fu L, Koyama T, Nara N. Effect of notch ligands on in vitro sensitivity to chemo-therapeutic drugs in leukemia and lymphoma cells. Oncol Rep. 2005.09; 14 (3): 723-726. ( PubMed )

  52. Murata-Ohsawa M, Tohda S, Kogoshi H, Sakano S, Nara N. The Notch ligand, Delta-1, alters retinoic acid (RA)-induced neutrophilic differentiation into monocytic and reduces RA-induced apoptosis in NB4 cells. Leuk Res. 2005.02; 29 (2): 197-203. ( PubMed, DOI )

  53. Murata-Ohsawa M, Tohda S, Kogoshi H, Nara N. The Notch ligand, Delta-1, reduces TNF-alpha-induced growth suppression and apoptosis by decreasing activation of caspases in U937 cells. Int J Mol Med. 2004.11; 14 (5): 861-866. ( PubMed )

  54. Murata-Ohsawa M, Tohda S, Nara N. Cellular analysis of growth suppression induced by the Notch ligands, Delta-1 and Jagged-1 in two myeloid leukemia cell lines. Int J Mol Med. 2004.08; 14 (2): 223-226. ( PubMed )

  55. Saito R, Takahashi R, Sawabe E, Koyano S, Takahashi Y, Shima M, Ushizawa H, Fujie T, Tosaka N, Kato Y, Moriya K, Tohda S, Tojo N, Koike R, Kubota T. First Report of KPC-2 Carbapenemase-Producing Klebsiella pneumoniae in Japan. Antimicrob Agents Chemother. 2014.05; 58 (5): 2961-2963. ( PubMed, DOI )

  56. Murata-Ohsawa M, Tohda S, Sakano S, Nara N. The Notch ligand, Delta-1, partially inhibits GM-CSF-induced differentiation and apoptosis along with reducing the cleavage of PARP in U937 cells. Int J Mol Med. 2004.03; 13 (3): 419-423. ( PubMed )

  57. Nagao T, Kurosu T, Umezawa Y, Nogami A, Oshikawa G, Tohda S, Yamamoto M, Miura O. Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera. PLoS ONE. 2014; 9 (1): e84746. ( PubMed, DOI )

  58. Siegers GM, Dhamko H, Wang XH, Mathieson AM, Kosaka Y, Felizardo TC, Medin JA, Tohda S, Schueler J, Fisch P, Keating A. Human Vδ1 γδ T cells expanded from peripheral blood exhibit specific cytotoxicity against B-cell chronic lymphocytic leukemia-derived cells. Cytotherapy. 2011.07; 13 (6): 753-764. ( PubMed, DOI )

  59. Nara N, Suzuki T, Tohda S. The current medical education system in the world. J Med Dent Sci. 2011; 58 (2): 79-83. ( PubMed )

  60. Nara N, Beppu M, Tohda S, Suzuki T. The introduction and effectiveness of simulation-based learning in medical education. Intern Med. 2009; 48 (17): 1515-1519. ( PubMed )

  61. Nemoto Y, Kanai T, Tohda S, Totsuka T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Fukuda T, Miura O, Yagita H, Watanabe M. Negative feedback regulation of colitogenic CD4+ T cells by increased granulopoiesis. Inflamm Bowel Dis. 2008.11; 14 (11): 1491-1503. ( PubMed, DOI )

  62. Kobayashi T, Terada Y, Kuwana H, Tanaka H, Okado T, Kuwahara M, Tohda S, Sakano S, Sasaki S. Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury. Kidney Int. 2008.06; 73 (11): 1240-1250. ( PubMed, DOI )

  63. Morita-Hoshi Y, Tohda S, Miura O, Nara N. An autopsy case of multicentric Castleman's disease associated with interstitial nephritis and secondary AA amyloidosis. Int J Hematol. 2008.01; 87 (1): 69-74. ( PubMed, DOI )

  64. Nara N, Kurokawa H, Tohda S, Tomiyama J, Nagata K, Tanikawa S. Effect of vesnarinone, a quinolinone derivative, on the growth of leukemic blasts in acute myelogenous leukemia. Exp Hematol. 1997.03; 25 (3): 199-204. ( PubMed )

  65. Imai Y, Yasuhara S, Hanafusa N, Ohsaka A, Enokihara H, Tomizuka H, Sonoyama M, Miura YS, Tohda S, Nara N, Takahashi A. Clonal involvement of eosinophils in therapy-related myelodysplastic syndrome with eosinophilia, translocation t(1;7) and lung cancer. Br J Haematol. 1996.12; 95 (4): 710-714. ( PubMed )

  66. Nara N, Kurokawa H, Tohda S, Tomiyama J, Nagata K, Tanikawa S. The effect of basic and acidic fibroblast growth factors (bFGF and aFGF) on the growth of leukemic blast progenitors in acute myelogenous leukemia. Exp Hematol. 1995.08; 23 (9): 1030-1034. ( PubMed )

  67. Koyama T, Hirosawa S, Kawamata N, Tohda S, Aoki N. All-trans retinoic acid upregulates thrombomodulin and downregulates tissue-factor expression in acute promyelocytic leukemia cells: distinct expression of thrombomodulin and tissue factor in human leukemic cells. Blood. 1994.11; 84 (9): 3001-3009. ( PubMed )

  68. Nara N, Tohda S. Successful treatment of refractory pure red cell aplasia by buserelin acetate. Acta Haematol. 1994; 92 (1): 42-45. ( PubMed )

  69. Murohashi I, Tohda S, Imai Y, Hirai Y, Nara N. Growth potentiating activity of endogenous production of interleukin-1 and tumor necrosis factor alpha in blast cells of acute myeloblastic leukemia. Exp Hematol. 1993.07; 21 (7): 846-851. ( PubMed )

  70. Nara N, Chen GJ, Murohashi I, Tohda S, Imai Y, Tomiyama J, Nagata K, Suzuki T, Tanikawa S, Shiina S. The in vitro growth patterns and drug sensitivities of leukemic blast progenitors among the subtypes of acute myelocytic leukemia. Exp Hematol. 1992.08; 20 (7): 904-908. ( PubMed )

  71. Kawamata N, Maruyama Y, Toda S, Takase K, Akiyama H, Sakamaki H, Onozawa Y. A case of chronic lymphocytic leukaemia with myeloid associated antigen. Br J Haematol. 1992.01; 80 (1): 129-130. ( PubMed )

  72. Suzuki T, Tohda S, Nagata K, Imai Y, Murohashi I, Nara N. Enhanced effect of mutant granulocyte-colony-stimulating factor (KW-2228) on the growth of normal and leukemic hemopoietic progenitor cells in comparison with recombinant human granulocyte-colony-stimulating factor (G-CSF). Acta Haematol. 1992; 87 (4): 181-189. ( PubMed )

  73. Nara N, Tohda S, Suzuki T, Nagata K, Tanikawa S, Imai Y, Tomiyama J, Shiina S. Comparison of the proliferative activity and sensitivity to cytosine arabinoside of leukemic blast progenitors in acute myeloblastic leukemia at diagnosis and in relapse. Acta Haematol. 1992; 88 (1): 17-21. ( PubMed )

  74. Suzuki T, Bessho M, Hirashma K, Tohda S, Nagata K, Imai Y, Nara N. Interleukin-6 reduces the optimal growth in vitro of leukemic blast progenitors from acute myeloblastic leukemia patients. Acta Haematol. 1992; 87 (1-2): 63-68. ( PubMed )

  75. Yamashita Y, Tohda S, Nagata K, Suzuki T, Imai Y, Nara N. The in vitro effect of vincristine on the blast cell renewal in acute myeloblastic leukemia. Jpn J Med. 1991.09; 30 (5): 412-419. ( PubMed )

  76. Suzuki T, Bessho M, Hirashima K, Tohda S, Nagata K, Morio T, Imai Y, Nara N. Enhancement by transforming growth factor-beta 1 (TGF-beta 1) of the proliferation of leukemic blast progenitors stimulated with IL-3. J Cell Physiol. 1991.09; 148 (3): 396-403. ( PubMed, DOI )

  77. Imai Y, Nara N, Tohda S, Nagata K, Suzuki T, Nagasawa M, Murohashi I, Aoki N. Antiproliferative and differentiative effects of recombinant interleukin-4 on a granulocyte colony-stimulating factor-dependent myeloblastic leukemic cell line. Blood. 1991.07; 78 (2): 471-478. ( PubMed )

  78. Imai Y, Tohda S, Nagata K, Suzuki T, Nara N, Aoki N. Effects of recombinant interleukin 4 on the growth and differentiation of blast progenitors stimulated with G-CSF, GM-CSF and IL-3 from acute myeloblastic leukaemia patients. Br J Haematol. 1991.06; 78 (2): 173-179. ( PubMed )

  79. Nara N, Tohda S, Suzuki T, Nagata K, Yamashita Y, Imai Y, Maruyama Y, Tomiyama J. Effects of N4-behenoyl-1-beta-D-arabinofuranosylcytosine on blast progenitors of acute myeloblastic leukemia. Cancer Res. 1990.12; 50 (23): 7587-7592. ( PubMed )

  80. Suzuki T, Morio T, Tohda S, Nagata K, Yamashita Y, Imai Y, Aoki N, Hirashima K, Nara N. Effects of interleukin-6 and granulocyte colony-stimulating factor on the proliferation of leukemic blast progenitors from acute myeloblastic leukemia patients. Jpn J Cancer Res. 1990.10; 81 (10): 979-986. ( PubMed )

  81. Nara N, Suzuki T, Nagata K, Tohda S, Yamashita Y, Nakamura Y, Imai Y, Morio T, Minamihisamatsu M. Granulocyte colony-stimulating factor-dependent growth of an acute myeloblastic leukemia cell line. Jpn J Cancer Res. 1990.06; 81 (6-7): 625-631. ( PubMed )

  82. Murohashi I, Tohda S, Suzuki T, Nagata K, Yamashita Y, Nara N. Mechanism of action of interleukin 1 on the progenitors of blast cells in acute myeloblastic leukemia. Exp Hematol. 1990.02; 18 (2): 133-137. ( PubMed )

  83. Nara N, Tohda S, Suzuki T, Nagata K, Yamashita Y, Imai Y, Morio T, Bessho M, Shibuya A, Adachi Y. Terminal differentiation to mature neutrophils and eosinophils in suspension culture of the blast progenitors in acute myeloblastic leukemia. Hematol Pathol. 1990; 4 (3): 125-134. ( PubMed )

  84. Nara N, Tohda S, Nagata K, Suzuki T, Yamashita Y, Imai Y. Effect of platelet-derived growth factor on the proliferation of blast progenitors from acute myeloblastic leukemia patients. Acta Haematol. 1990; 83 (4): 187-192. ( PubMed )

  85. Maruyama Y, Tohda S, Nagata K, Suzuki T, Murohashi I, Nara N. Role of humoral and cellular factors on the growth of blast progenitors of acute myeloblastic leukemia in serum-free culture. Hematol Pathol. 1990; 4 (3): 115-123. ( PubMed )

  86. Nagata K, Tohda S, Suzuki T, Nara N. Effects of recombinant human tumor necrosis factor on the self-renewal capacity of leukemia blast progenitors in acute myeloblastic leukemia. Leukemia. 1989.09; 3 (9): 626-630. ( PubMed )

  87. Nara N, Tohda S, Nagata K, Suzuki T, Yamashita Y. Inhibition of the in vitro growth of blast progenitors from acute myeloblastic leukemia patients by transforming growth factor-beta (TGF-beta). Leukemia. 1989.08; 3 (8): 572-577. ( PubMed )

  88. Murohashi I, Tohda S, Suzuki T, Nagata K, Yamashita Y, Nara N. Autocrine growth mechanisms of the progenitors of blast cells in acute myeloblastic leukemia. Blood. 1989.07; 74 (1): 35-41. ( PubMed )

  89. Murohashi I, Tohda S, Suzuki T, Nagata K, Yamashita Y, Nara N, Aoki N. Expression of interleukin 1 beta receptors on blast cells in acute myeloblastic leukemia: comparison with interleukin 1 beta proliferative activity. Cancer Res. 1989.06; 49 (12): 3431-3435. ( PubMed )

  90. Murohashi I, Tohda S, Suzuki T, Nagata K, Yamashita Y, Nara N. Specific binding of radioiodinated human GM-CSF to the blast cells of acute myeloblastic leukemia. Leuk Res. 1989; 13 (7): 599-604. ( PubMed )

  91. S Nogami, N Kawaguchi-Ihara, E Shiratori, M Ohtaka, M Itoh, S Tohda. Detection of the MYD88 mutation by the combination of the allele-specific PCR and quenching probe methods. Int J Lab Hematol. 2017.04; 39 (2): 163-168. ( PubMed, DOI )

  92. Shinji Ogihara, Ryoichi Saito, Etsuko Sawabe, Takahiro Kozakai, Mari Shima, Yoshibumi Aiso, Toshihide Fujie, Yoko Nukui, Ryuji Koike, Michio Hagihara, Shuji Tohda. Molecular typing of methicillin-resistant Staphylococcus aureus: Comparison of PCR-based open reading frame typing, multilocus sequence typing, and Staphylococcus protein A gene typing. J. Infect. Chemother.. 2018.04; 24 (4): 312-314. ( PubMed, DOI )

  93. Erika Shiratori, Mai Itoh, Shuji Tohda. MYD88 Inhibitor ST2825 Suppresses the Growth of Lymphoma and Leukaemia Cells. Anticancer Res.. 2017.07; 37 (11): 6203-6209. ( PubMed, DOI )

  94. Mika Ohtaka, Mai Itoh, Shuji Tohda. BMI1 Inhibitors Down-regulate NOTCH Signaling and Suppress Proliferation of Acute Leukemia Cells. Anticancer Res.. 2017.08; 37 (11): 6047-6053. ( PubMed, DOI )

  95. Miyako Murakawa, Yasuhiro Asahina, Hiroko Nagata, Mina Nakagawa, Sei Kakinuma, Sayuri Nitta, Fukiko Kawai-Kitahata, Satoshi Otani, Shun Kaneko, Masato Miyoshi, Tomoyuki Tsunoda, Yu Asano, Ayako Sato, Yasuhiro Itsui, Seishin Azuma, Toshihiko Nouchi, Yohei Furumoto, Tooru Asano, Yoshimichi Chuganji, Shuji Tohda, Mamoru Watanabe. ITPA gene variation and ribavirin-induced anemia in patients with genotype 2 chronic hepatitis C treated with sofosbuvir plus ribavirin. Hepatol. Res.. 2017.10; 47 (11): 1212-1218. ( PubMed, DOI )

  96. Yuki Okuhashi, Mai Itoh, Shuji Tohda. Hedgehog Stimulation Suppresses Clonogenicity and Activates NOTCH Signalling in T-lymphoblastic Leukaemia Jurkat Cells. Anticancer Res.. 2017.05; 37 (9): 5005-5009. ( PubMed, DOI )

  97. Miyako Murakawa, Yasuhiro Asahina, Fukiko Kawai-Kitahata, Mina Nakagawa, Sayuri Nitta, Satoshi Otani, Hiroko Nagata, Shun Kaneko, Yu Asano, Tomoyuki Tsunoda, Masato Miyoshi, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Yasuhito Tanaka, Sayuki Iijima, Kaoru Tsuchiya, Namiki Izumi, Shuji Tohda, Mamoru Watanabe. Hepatic IFNL4 expression is associated with non-response to interferon-based therapy through the regulation of basal interferon-stimulated gene expression in chronic hepatitis C patients. J. Med. Virol.. 2017.07; 89 (7): 1241-1247. ( PubMed, DOI )

  98. Salwa M Okasha, Mai Itoh, Shuji Tohda. Sirtuin 1 Activation Suppresses the Growth of T-lymphoblastic Leukemia Cells by Inhibiting NOTCH and NF-κB Pathways. Anticancer Res. 2020.06; 40 (6): 3155-3161. ( PubMed, DOI )

  99. Tatsuya Saito, Mai Itoh, Shuji Tohda. Metformin suppresses the growth of leukemia cells partly through downregulation of AXL receptor tyrosine kinase. Leuk Res. 2020.05; 94 106383. ( PubMed, DOI )

  100. Yuki Koda, Mai Itoh, Shuji Tohda. Effects of MERTK Inhibitors UNC569 and UNC1062 on the Growth of Acute Myeloid Leukaemia Cells. Anticancer Res.. 2018; 38 (1): 199-204. ( PubMed, DOI )

  101. Nagano K, Tani-Sassa C, Iwasaki Y, Takatsuki Y, Yuasa S, Takahashi Y, Nakajima J, Sonobe K, Ichimura N, Nukui Y, Takeuchi H, Tanimoto K, Tanaka Y, Kimura A, Tohda S. SARS-CoV-2 R.1 lineage variants that prevailed in Tokyo in March 2021. Journal of medical virology. 2021.07; ( PubMed, DOI )

  102. Mitsumura Takahiro, Okamoto Tsukasa, Shirai Tsuyoshi, Iijima Yuki, Sakakibara Rie, Honda Takayuki, Ishizuka Masahiro, Aiboshi Junichi, Tateishi Tomoya, Tamaoka Meiyo, Shigemitsu Hidenobu, Arai Hirokuni, Otomo Yasuhiro, Tohda Shuji, Anzai Tatsuhiko, Takahashi Kunihiko, Yasuda Shinsuke, Miyazaki Yasunari. Predictors associated with clinical improvement of SARS-CoV-2 pneumonia JOURNAL OF INFECTION AND CHEMOTHERAPY. 2021.06; 27 (6): 857-863. ( PubMed, DOI )

  103. Sonoda Yuri, Itoh Mai, Tohda Shuji. Effects of HOXA9 Inhibitor DB818 on the Growth of Acute Myeloid Leukaemia Cells ANTICANCER RESEARCH. 2021.04; 41 (4): 1841-1847. ( PubMed, DOI )

  104. Yamazaki Azusa, Ohkawa Ryunosuke, Yamagata Yuka, Horiuchi Yuna, Lai Shao-Jui, Kameda Takahiro, Ichimura Naoya, Tohda Shuji, Tozuka Minoru. Apolipoprotein C-II and C-III preferably transfer to both high-density lipoprotein (HDL)(2) and the larger HDL3 from very low-density lipoprotein (VLDL) BIOLOGICAL CHEMISTRY. 2021.03; 402 (4): 439-449. ( PubMed, DOI )

  105. Shimano S., Ohkawa R., Nambu M., Sasaoka M., Yamazaki A., Fujii Y., Horiuchi Y., Lai S.J., Kameda T., Ichimura N., Fujita K., Tohda S. and Tozuka M.. Marked changes in serum amyloid A distribution and high-density lipoprotein structure during acute inflammation BioMed Research International. 2021.01;

  106. Shimano Shitsuko, Ohkawa Ryunosuke, Nambu Mayu, Sasaoka Mai, Yamazaki Azusa, Fujii Yuki, Horiuchi Yuna, Lai Shao-Jui, Kameda Takahiro, Ichimura Naoya, Fujita Koji, Tohda Shuji, Tozuka Minoru. Marked Changes in Serum Amyloid A Distribution and High-Density Lipoprotein Structure during Acute Inflammation BIOMED RESEARCH INTERNATIONAL. 2021.01; 2021 9241259. ( PubMed, DOI )

  107. Kameda T., Horiuchi Y., Shimano S., Yano K., Lai S.J., Ichimura N., Tohda S., Kurihara Y., Tozuka M., Ohkawa, R. Effect of myeloperoxidase oxidation and N-homocysteinylation of high-density lipoprotein on endothelial repair function Biological Chemistry. 2021;

  108. Usui Y, Nukui Y, Koike R, Tohda S, Saito R. Draft Genome Sequence of a Clostridioides difficile Sequence Type 97 Strain Belonging to Hypervirulent Clade 2. Microbiology resource announcements. 2020.04; 9 (14): ( PubMed, DOI )

  109. Usui Y, Ayibieke A, Kamiichi Y, Okugawa S, Moriya K, Tohda S, Saito R. Impact of deoxycholate on <i>Clostridioides difficile</i> growth, toxin production, and sporulation. Heliyon. 2020.04; 6 (4): e03717. ( PubMed, DOI )

  110. Yamazaki, A., Ohkawa, R., Yamagata, Y., Horiuchi, Y., Lai, S.J., Kameda, T., Ichimura, N., Tohda, S. and Tozuka, M.. Apolipoprotein C-II and C-III preferably transfer to both HDL2 and the larger HDL3 from VLDL Biological Chemistry. 2020;

  111. Nukui Y, Chino T, Tani C, Sonobe K, Aiso Y, Tohda S, Koike R, Saito R. Molecular epidemiologic and clinical analysis of Helicobacter cinaedi bacteremia in Japan. Helicobacter. 2019.11; e12675. ( PubMed, DOI )

  112. Saito Ryoichi, Usui Yukino, Ayibieke Alafate, Nakajima Jun, Prah Isaac, Sonobe Kazunari, Aiso Yoshibumi, Ito Shiori, Itsui Yasuhiro, Hadano Yoshiro, Nukui Yoko, Koike Ryuji, Tohda Shuji. Hypervirulent clade 2, ribotype 019/sequence type 67 Clostridioides difficile strain from Japan GUT PATHOGENS. 2019.11; 11 (1): 54. ( PubMed, DOI )

  113. Nogami Ayako, Watanabe Daisuke, Okada Keigo, Akiyama Hiroki, Umezawa Yoshihiro, Nagao Toshikage, Tohda Shuji, Miura Osamu. FLT3-ITD Enhances Proliferation and Survival of AML Cells through Activation of RSK1 to Upregulate the mTORC1/eIF4F Pathway Cooperatively with PIM or PI3K and to Inhibit Bad and Bim BLOOD. 2019.11; 134 ( DOI )

  114. Itoh M, Okuhashi Y, Takahashi Y, Sonoda Y, Mohammad S, Saito T, Shiratori E, Tohda S. Hypoxia Up-regulates HIF Expression While Suppressing Cell Growth and NOTCH Activity in Leukaemia Cells. Anticancer research. 2019.08; 39 (8): 4165-4170. ( PubMed, DOI )

  115. Nukui Y, Ayibieke A, Taniguchi M, Aiso Y, Shibuya Y, Sonobe K, Nakajima J, Kanehira S, Hadano Y, Tohda S, Koike R, Saito R. Whole-genome analysis of EC129, an NDM-5-, CTX-M-14-, OXA-10- and MCR-1-co-producing Escherichia coli ST167 strain isolated from Japan. Journal of global antimicrobial resistance. 2019.07; 18 148-150. ( PubMed, DOI )

  116. Hamada S, Hasegawa Y, Oono A, Suzuki A, Takahashi N, Nishimura T, Koyama T, Hagihara M, Tohda S, Furukawa T, Hirao K, Sasano T. Author Correction: Differential Assessment of Factor Xa Activity and Global Blood Coagulability Utilizing Novel Dielectric Coagulometry. Scientific reports. 2019.03; 9 (1): 4957. ( PubMed, DOI )

  117. Horiuchi Y, Ohkawa R, Lai SJ, Shimano S, Hagihara M, Tohda S, Kameda T, Tozuka M. Usefulness of apolipoprotein B-depleted serum in cholesterol efflux capacity assays using immobilized liposome-bound gel beads. Bioscience reports. 2019.03; ( PubMed, DOI )

  118. Kawaguchi-Ihara Noriko, Zhao Yan, Nakamura Suzune, Suzuki Keiko, Zhang Yi, Tohda Shuji, Murohashi Ikuo. Chloroquine Inhibits Self-Renewal of Blast Progenitors Synergistically With Phytochemicals or Nonsteroidal Anti-inflammatory Drugs in Hematological Malignant Cell Lines ANTICANCER RESEARCH. 2019.01; 39 (1): 87-98. ( PubMed, DOI )

  119. Okuhashi Yuki, Itoh Mai, Tohda Shuji. GLI1 and CTNNB1 Knockdown Activates NOTCH and mTOR Signalling in NB4 Myeloid Leukaemia Cells ANTICANCER RESEARCH. 2018.11; 38 (11): 6329-6332. ( PubMed, DOI )

  120. Hamada Satomi, Hasegawa Yuki, Oono Ai, Suzuki Anna, Takahashi Naomi, Nishimura Takuro, Koyama Takatoshi, Hagihara Michio, Tohda Shuji, Furukawa Tetsushi, Hirao Kenzo, Sasano Tetsuo. Differential Assessment of Factor Xa Activity and Global Blood Coagulability Utilizing Novel Dielectric Coagulometry SCIENTIFIC REPORTS. 2018.10; 8 (1): 16129. ( PubMed, DOI )

  121. Wang S, Itoh M, Shiratori E, Ohtaka M, Tohda S. NOTCH activation promotes glycosyltransferase expression in human myeloid leukemia cells. Hematology reports. 2018.09; 10 (3): 7576. ( PubMed, DOI )

  122. Yonekura S, Itoh M, Shiratori E, Ohtaka M, Tohda S. FOXP3 knockdown inhibits the proliferation and reduces NOTCH1 expression of T cell acute lymphoblastic leukemia cells. BMC research notes. 2018.08; 11 (1): 582. ( PubMed, DOI )

  123. Horiuchi Yuna, Lai Shao-Jui, Yamazaki Azusa, Nakamura Ayaka, Ohkawa Ryunosuke, Yano Kouji, Kameda Takahiro, Okubo Shigeo, Shimano Shitsuko, Hagihara Michio, Tohda Shuji, Tozuka Minoru. VALIDATION AND APPLICATION OF A NOVEL CHOLESTEROL EFFLUX ASSAY USING IMMOBILIZED LIPOSOMES AS A SUBSTITUTE FOR CULTURED CELLS ATHEROSCLEROSIS SUPPLEMENTS. 2018.06; 32 59.

  124. Horiuchi Yuna, Lai Shao-Jui, Yamazaki Azusa, Nakamura Ayaka, Ohkawa Ryunosuke, Yano Kouji, Kameda Takahiro, Okubo Shigeo, Shimano Shitsuko, Hagihara Michio, Tohda Shuji, Tozuka Minoru. Validation and application of a novel cholesterol efflux assay using immobilized liposomes as a substitute for cultured cells BIOSCIENCE REPORTS. 2018.04; 38 (2): ( PubMed, DOI )

  125. Murakawa Miyako, Asahina Yasuhiro, Nagata Hiroko, Nakagawa Mina, Kakinuma Sei, Nitta Sayuri, Kawai-Kitahata Fukiko, Otani Satoshi, Kaneko Shun, Miyoshi Masato, Tsunoda Tomoyuki, Asano Yu, Sato Ayako, Itsui Yasuhiro, Azuma Seishin, Nouchi Toshihiko, Furumoto Yohei, Asano Tooru, Chuganji Yoshimichi, Tohda Shuji, Watanabe Mamoru. ソホスブビル+リバビリン治療を行ったC型慢性肝炎ジェノタイプ2患者におけるITPA遺伝的変異とリバビリン誘発性貧血(ITPA gene variation and ribavirin-induced anemia in patients with genotype 2 chronic hepatitis C treated with sofosbuvir plus ribavirin) Hepatology Research. 2017.10; 47 (11): 1212-1218. ( ichushi )

  126. Yoshimoto Ryoto, Watanabe Ken, Uchida Emi, Suwa Shihoko, Tohda Shuji, Hatano Masahiko, Miura Osamu, Fukuda Tetsuya. IVNS1ABP/Nd1は新規治療標的分子として難治性リンパ腫に強発現する(IVNS1ABP/Nd1 is highly expressed in refractory lymphoma as a novel therapeutic target molecule) 臨床血液. 2017.09; 58 (9): 1655. ( ichushi )

  127. Gene Igawa, Mika Casey, Etsuko Sawabe, Yoko Nukui, Shu Okugawa, Kyoji Moriya, Ryuji Koike, Shuji Tohda, Ryoichi Saito. Comparison of agar dilution and broth microdilution methods for Clostridium difficile antimicrobial susceptibility testing. J Glob Antimicrob Resist. 2016.12; 7 43-45. ( PubMed, DOI )

  128. Hiroko Nagata, Mina Nakagawa, Yuki Nishimura-Sakurai, Yu Asano, Tomoyuki Tsunoda, Masato Miyoshi, Shun Kaneko, Fumio Goto, Satoshi Otani, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Naoko Tojo, Shuji Tohda, Yasuhiro Asahina, Mamoru Watanabe, . Serial measurement of Wisteria floribunda agglutinin positive Mac-2-binding protein is useful for predicting liver fibrosis and the development of hepatocellular carcinoma in chronic hepatitis C patients treated with IFN-based and IFN-free therapy. Hepatol Int. 2016.11; 10 (6): 956-964. ( PubMed, DOI )

  129. Shinji Ogihara, Ryoichi Saito, Etsuko Sawabe, Michio Hagihara, Shuji Tohda. First Japanese case of infectious endocarditis due to Enterococcus faecalis small-colony variants. J. Infect. Chemother.. 2016.10; 22 (10): 716-719. ( PubMed, DOI )

  130. Noriko Kawaguchi-Ihara, Mai Itoh, Ikuo Murohashi, Shuji Tohda. Establishment of a quenching probe method for detection of NPM1 mutations in acute myeloid leukemia cells. Oncol Lett. 2016.04; 11 (4): 2429-2432. ( PubMed, DOI )

  131. 秋山 めぐみ,吉藤 康太,福田 哲也,東田 修二,三木 徹,三浦 修,山本 正英. 自己免疫性溶血性貧血に対するprednisolone治療中に発症した皮膚症状を伴わない劇症型内臓播種性VZV感染症 臨床血液. 2016.04; 57 (4): 467-471. ( PubMed, DOI )

  132. Mari Kamiya, Peter Y Shane, Makoto Soejima, Shuji Tohda, Nobuyuki Miyasaka, Hitoshi Kohsaka. IgG4-Related Sialoadenitis with a Skin Lesion and Multiple Mononeuropathies Suggesting Coexistent Cryoglobulinemic Vasculitis. Intern. Med.. 2016; 55 (10): 1355-1361. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Horiuchi Y., Lai SJ., Shimano S., Kameda T., Ichimura N., Tohda S., Tozuka M. and Ohkawa R. Novel cholesterol efflux assay using immobilized liposome-bound gel beads: confirmation and improvement for application in clinical laboratory. 2020 AACC Annual Scientific Meeting & Clinical Lab Expo 2020.12.16 On-line

  2. Shimano S., Ohkawa R., Nambu M., Sasaoka M., Yamazaki A., Fujii Y., Igarashi K., Horiuchi Y., Lai SJ., Kameda T., Ichimura N., Fujita K., Tohda S. and Tozuka M. Dramatic change of high-density lipoprotein structure and serum amyloid A distribution after orthopedic surgery. 2020 AACC Annual Scientific Meeting & Clinical Lab Expo 2020.12.16 On-line

  3. Horiuchi Y., Lai SJ., Shimano S., Kameda T., Ichimura N., Tohda S., Tozuka M. and Ohkawa R. Novel cholesterol efflux assay using immobilized liposome-bound gel beads: confirmation and improvement for application in clinical laboratory. 2020 AACC Annual Scientific Meeting & Clinical Lab Expo 2020.12.16 On-line

  4. Ayako Nogami, Watanabe Daisuke, Keigo Okada, Hiroki Akiyama, Yoshihiro Umezawa, Toshikage Nagao, Shuji Tohdaand Osamu Miura. FLT3-ITD Enhances Proliferation and Survival of AML Cells through Activation of RSK1 to Upregulate the mTORC1/eIF4F Pathway Cooperatively with PIM or PI3K and to Inhibit Bad and Bim. 60th ASH Annual Meeting and Exposition 2019.12.01 FL, Orange County Convention Center

  5. Chihiro Tani, Kazunari Sonobe, Ayuka Kobayashi, Jun Nakajima, Rieko Takahashi, Saki Kanehira, Sonoka Yuasa, Tomoko Motohashi, Michio Hagihara, Takashi Yaguchi, Shuji Tohda. The impact of the morphological difference of fungal colonies among several potato dextrose agars on the identification. The 30th World Congress of World Association of Societies of Pathology and Laboratory Medicine 2019.09.20

  6. Yamazaki A., Ohkawa R., Horiuchi Y., Lai SJ., Shimano S., Itoi A., Ichimura N., Hagihara M., Tozuka M., Tohda S. Analysis of Apolipoprotein C-II and C-III Transfers between High-density Lipoprotein and Very Low-density Lipoprotein. 2019 KAMT congress & International conference 2019.08.31 Pyeongchang

  7. Fujii Y., Ohkawa R., Lai SJ., Horiuchi Y., Shimano S., Ohno K., Ichimura N., Hagihara M., Tozuka M., Tohda S. Analysis of Serum Amyloid A Containing HDL Formation in HepG2. 2019 KAMT congress & International conference 2019.08.31 Pyeongchang

  8. Tatsuya Saito, Mai Itoh, Shuji Tohda. Metformin inhibits the growth of myeloid leukemia cells partly due to suppression of tyro3 expression. 24th Congress of European Hematology Association 2019.06.14 Amsterdam

  9. Horiuchi Y., Ohkawa R., Lai SJ., Shimano S., Hagihara M., Tohda S., and Tozuka M. Availability of apoB-depleted serum in clinical assay for cholesterol efflux capacity using immobilized liposome-bound gel beads. 3rd IFCC-EFLM European Congress of Clinical Chemistry and Laboratory Medicine 2019.05.19 Barcelona

  10. Kazuaki Yamamoto, Yumi Iwasaki, Michio Hagihara, Shuji Tohda. Multiplex strip PCR test for rapid and simultaneous detection of twelve kinds of virus DNA in patients' samples. 15th congress of the Asian society of clinical pathology and laboratory medicine 2018.09.07

  11. Mika Ohtaka, Mai Itoh, and Shuji Tohda. BMI1 inhibitors suppress cell growth and NOTCH signalling of acute leukemia cells. 46th Annual Scientific Meeting of the International Society for Experimental Hematology 2017.08.26 Frankfurt, Germany

  12. Erika Shiratori, Mai Itoh, Mika Ohtaka, Shohei Nogami, Shuji Tohda. Mechanisms of suppressive effects of MYD88 Inhibitors on the Growth of Lymphoma and Leukemia Cells. The 58th American Society of Hematology 2016.12.04 San Diego

  13. Kazuaki Yamamoto, Seiya Watanabe, Michio Hagihara, Shuji Tohda. Development of a novel measurement method for L-hydroxyproline using a new enzyme. The 32th World Congress of Biomedical Laboratory Science 2016.09.02

  14. Naoya Ichimura, Ayako Itoi, Yuki Ohkubo, Yuki Koda, Michio Hagihara, Shuji Tohda. Evaluation of an internal QC application for correctly recognizing immature granulocytes on blood smear. The 32th World Congress of Biomedical Laboratory Science 2016.09.02 Kobe

  15. Naoya Ichimura, Ayako Itoi, Yuki Ohkubo, Yuki Koda, Michio Hagihara, Shuji Tohda. Development of an internal quality control application for immature granulocytes differential. The 32th World Congress of Biomedical Laboratory Science 2016.09.02 Kobe

  16. Shohei Nogami, Mai Itoh, Shuji Tohda. Clinical usefulness of allele-specific/quenching probe method for detection of the MYD88 L265P mutation. The 14th Asian Society for Clinical Pathology and Laboratory Medicine Congress 2016.03.26 Taipei

  17. 渡邉健 他. Short chemotherapy prior to 90Y-ibritumomab tiuxetan for relapsed FL in a single institution.. 第77回日本血液学会学術集会 2015.10.18 石川県金沢市

  18. Yuki Okuhashi, Yusuke Takahashi, Mika Ohtaka, Erika Shiratori, Shijun O, Mai Itoh, Shuji Tohda. Effects of GLI1 and CTNNB1 knockdown on NOTCH signaling of leukemia cells. The 56th American Society of Hematology 2014.12.06 San Francisco, USA

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Awards & Honors 【 display / non-display

  • Fellowship (Medical Research Council of Canada),1991