Xie C, Rashed F, Sasaki Y, Khan M, Qi J, Kubo Y, Matsumoto Y, Sawada S, Sasaki Y, Ono T, Ikeda T, Akiyoshi K, Aoki K. Comparison of Osteoconductive Ability of Two Types of Cholesterol-Bearing Pullulan (CHP) Nanogel-Hydrogels Impregnated with BMP-2 and RANKL-Binding Peptide: Bone Histomorphometric Study in a Murine Calvarial Defect Model. International journal of molecular sciences. 2023.06; 24 (11): ( PubMed, DOI )

Matsuno H, Li B, Okawara H, Toyoshima Y, Xie C, Khan M, Murakami N, Aoki K, Wakabayashi N. Effect of tension and compression on dynamic alveolar histomorphometry. Journal of the mechanical behavior of biomedical materials. 2023.02; 138 105666. ( PubMed, DOI )

Hitomi Matsuno, Bin Li, Hisami Okawara, Yusuke Toyoshima, Cangyou Xie, Masud Khan, Natsuko Murakami, Kazuhiro Aoki, Noriyuki Wakabayashi. Effect of tension and compression on dynamic alveolar histomorphometry Journal of the Mechanical Behavior of Biomedical Materials. 2023.02;

Takahashi K, Amano H, Urano T, Li M, Oki M, Aoki K, Amizuka N, Nakayama KI, Nakayama K, Udagawa N, Higashi N. p57Kip2 is an essential regulator of vitamin D receptor-dependent mechanisms. PloS one. 2023; 18 (2): e0276838. ( PubMed, DOI )

Xie Cangyou, Satake-Ozawa Michiko, Rashed Fatma, Khan Masud, Ikeda Masaomi, Hayashi Shunya, Sawada Shinichi, Sasaki Yoshihiro, Ikeda Tohru, Mori Yoshiyuki, Akiyoshi Kazunari, Aoki Kazuhiro. Perforated Hydrogels Consisting of Cholesterol-Bearing Pullulan (CHP) Nanogels: A Newly Designed Scaffold for Bone Regeneration Induced by RANKL-Binding Peptides and BMP-2 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022.07; 23 (14): 7768 (1)-7768 (15). ( PubMed, DOI )

Hirohashi Yuna, Kamijo Shingo, Khan Masud, Ikeda Masaomi, Oki Meiko, Matin Khairul, Rashed Fatma, Aoki Kazuhiro. Tetracycline, an Appropriate Reagent for Measuring Bone-Formation Activity in the Murine Model of the Streptococcus mutans-Induced Bone Loss FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2021.09; 11 714366. ( PubMed, DOI )

Gao Jing, Muroya Ryusuke, Huang Fei, Nagata Kengo, Shin Masashi, Nagano Ryoko, Tajiri Yudai, Fujii Shinsuke, Yamaza Takayoshi, Aoki Kazuhiro, Tamura Yukihiko, Inoue Mayuko, Chishaki Sakura, Kukita Toshio, Okabe Koji, Matsuda Miho, Mori Yoshihide, Kiyoshima Tamotsu, Jimi Eijiro. Bone morphogenetic protein induces bone invasion of melanoma by epithelial-mesenchymal transition via the Smad1/5 signaling pathway LABORATORY INVESTIGATION. 2021.09; 101 (11): 1475-1483. ( PubMed, DOI )

Rashed Fatma, Kamijyo Shingo, Shimizu Yuri, Hirohashi Yuna, Khan Masud, Sugamori Yasutaka, Murali Ramachandran, Aoki Kazuhiro. The Effects of Receptor Activator of NF-kappa B Ligand-Binding Peptides on Bone Resorption and Bone Formation FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021.07; 9 648084. ( PubMed, DOI )

Okawara H, Arai Y, Matsuno H, Marcián P, Borák L, Aoki K, Wakabayashi N. Effect of load-induced local mechanical strain on peri-implant bone cell activity related to bone resorption and formation in mice: An analysis of histology and strain distributions. Journal of the mechanical behavior of biomedical materials. 2021.04; 116 104370. ( PubMed, DOI )

Keo P, Matsumoto Y, Shimizu Y, Nagahiro S, Ikeda M, Aoki K, Ono T. A pilot study to investigate the histomorphometric changes of murine maxillary bone around the site of mini-screw insertion in regenerated bone induced by anabolic reagents. European journal of orthodontics. 2020.03; ( PubMed, DOI )

Takakura N, Matsuda M, Khan M, Hiura F, Aoki K, Hirohashi Y, Mori K, Yasuda H, Hirata M, Kitamura C, Jimi E. A novel inhibitor of NF-κB-inducing kinase prevents bone loss by inhibiting osteoclastic bone resorption in ovariectomized mice. Bone. 2020.03; 135 115316. ( PubMed, DOI )

Shigeki Nagahiro, Tomoki Uehara, Mariko Yamamoto Kawai, Preksa Keo, Hiroki Ochi, Shingo Sato, Shinji Kuroda, Takashi Ono, Michiyo Miyashin, Kazuhiro Aoki. RANKL-binding peptide promotes ectopic bone formation induced by BMP-2 gene transfer in murine gastrocnemius muscle Dental, Oral and Maxillofacial Research. 2020.01; 6 (1): ( DOI )

Amano Hitoshi, Iwaki Futoshi, Oki Meiko, Aoki Kazuhiro, Ohba Shinsuke. An osteogenic helioxanthin derivative suppresses the formation of bone-resorbing osteoclasts REGENERATIVE THERAPY. 2019.12; 11 290-296. ( PubMed, DOI )

Touyama K, Khan M, Aoki K, Matsuda M, Hiura F, Takakura N, Matsubara T, Harada Y, Hirohashi Y, Tamura Y, Gao J, Mori K, Kokabu S, Yasuda H, Fujita Y, Watanabe K, Takahashi Y, Maki K, Jimi E. Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis. Journal of cellular biochemistry. 2019.06; ( PubMed, DOI )

Sone E, Noshiro D, Ikebuchi Y, Nakagawa M, Khan M, Tamura Y, Ikeda M, Oki M, Murali R, Fujimori T, Yoda T, Honma M, Suzuki H, Ando T, Aoki K. The induction of RANKL molecule clustering could stimulate early osteoblast differentiation. Biochemical and biophysical research communications. 2019.02; 509 (2): 435-440. ( PubMed, DOI )

Ikebuchi Yuki, Aoki Shigeki, Honma Masashi, Hayashi Madoka, Sugamori Yasutaka, Khan Masud, Kariya Yoshiaki, Kato Genki, Tabata Yasuhiko, Penninger Josef M., Udagawa Nobuyuki, Aoki Kazuhiro, Suzuki Hiroshi. Coupling of bone resorption and formation by RANKL reverse signalling NATURE. 2018.09; 561 (7722): 195-200. ( PubMed, DOI )

Urata Mariko, Kokabu Shoichiro, Matsubara Takuma, Sugiyama Goro, Nakatomi Chihiro, Takeuchi Hiroshi, Hirata-Tsuchiya Shizu, Aoki Kazuhiro, Tamura Yukihiko, Moriyama Yasuko, Ayukawa Yasunori, Matsuda Miho, Zhang Min, Koyano Kiyoshi, Kitamura Chiaki, Jimi Eijiro. A peptide that blocks the interaction of NF-B p65 subunit with Smad4 enhances BMP2-induced osteogenesis JOURNAL OF CELLULAR PHYSIOLOGY. 2018.09; 233 (9): 7356-7366. ( PubMed, DOI )

Cui Xinnan, Murakami Tatsuya, Tamura Yukihiko, Aoki Kazuhiro, Hoshino Yu, Miura Yoshiko. Bacterial Inhibition and Osteoblast Adhesion on Ti Alloy Surfaces Modified by Poly(PEGMA-r-Phosmer) Coating ACS APPLIED MATERIALS & INTERFACES. 2018.07; 10 (28): 23674-23681. ( PubMed, DOI )

Hideaki Inagawa, Natsuki Suzuki, Kazuhiro Aoki, Noriyuki Wakabayashi. Potential for estimation of Young's modulus based on computed tomography numbers in bone: A validation study using a nano-indentation test on murine maxilla Dental, Oral and Craniofacial Research. 2018.01; 4 (4): 1-7. ( DOI )

Lin Ding, Peng Zhang, Xin Wang, Jia Hao, Kazuhiro Aoki, Shinji Kuroda, Shohei Kasugai. Effect of doxycycline-treated hydroxyapatite surface on bone apposition: A histomophometric study in murine maxillae. Dent Mater J. 2018.01; 37 (1): 130-138. ( PubMed, DOI )

Yasuhiro Shimizu, Masud Khan, Genki Kato, Kazuhiro Aoki & Takashi Ono. Occlusal disharmony-induced stress causes osteopenia of the lumbar vertebrae and long bones in mice. Scientific Reports. 2018.01; 8 (173): 1-9. ( DOI )

Aierken MULATI, Songtao WU, Kazuhiro AOKI, Shohei KASUGAI. Effects of Osteotomy with Drilling on Osteocytes Journal of Oral Tissue Engineering. 2017.12; 15 (2): 95-101. ( DOI )

Risako Mikami, Koji Mizutani, Akira Aoki, Yukihiko Tamura, Kazuhiro Aoki, Yuichi Izumi. Low-level ultrahigh-frequency and ultrashort-pulse blue laser irradiation enhances osteoblast extracellular calcification by upregulating proliferation and differentiation via transient receptor potential vanilloid 1 Lasers in Surgery and Medicine. 2017.12; ( DOI )

Toru Takemoto, Yuji Kabasawa, Yusuke Higuchi, Yasuhiko Tabata, Kazuhiro Aoki, Yukihiko Tamura, Hiroyuki Harada. Combination of the RANKL-binding peptide W9 and bFGF induces bone regeneration in the rat calvarial defect model. Dent Oral Craniofac Res. 2017.12; 4 (3): 1-7. ( DOI )

Boosana KABOOSAYA, Lia Kartika WULANSARI, Trang Nguyen V.N., Kazuhiro AOKI, Shohei KASUGAI. Ligation Period Required to Induce Periodontitis in Mice: Analysis with Micro-computed Tomography Journal of Oral Tissue Engineering. 2017.10; 15 (1): 25-34. ( DOI )

Md Zahirul Haque Bhuyan, Yukihiko Tamura, Eri Sone, Yuki Yoshinari, Chizuko Maeda, Mariko Takahashi, Yasuhiko Tabata, Ramachandran Murali, Yoshihiro Waki, Kazuhiro Aoki. The intra-articular injection of RANKL-binding peptides inhibits cartilage degeneration in a murine model of osteoarthritis. J. Pharmacol. Sci.. 2017.06; 134 (2): 124-130. ( PubMed, DOI )

Yasutaka Sugamori, Setsuko Mise-Omata, Chizuko Maeda, Shigeki Aoki, Yasuhiko Tabata, Ramachandran Murali, Hisataka Yasuda, Nobuyuki Udagawa, Hiroshi Suzuki, Masashi Honma, Kazuhiro Aoki. Peptide drugs accelerate BMP-2-induced calvarial bone regeneration and stimulate osteoblast differentiation through mTORC1 signaling. Bioessays. 2016.08; 38 (8): 717-725. ( PubMed, DOI )

Yuki Arai, Kazuhiro Aoki, Yasuhiro Shimizu, Yasuhiko Tabata, Takashi Ono, Ramachandran Murali, Setsuko Mise-Omata, Noriyuki Wakabayashi. Peptide-induced de novo bone formation after tooth extraction prevents alveolar bone loss in a murine tooth extraction model. Eur. J. Pharmacol.. 2016.07; 782 89-97. ( PubMed, DOI )

T Uehara, S Mise-Omata, M Matsui, Y Tabata, R Murali, M Miyashin, K Aoki. Delivery of RANKL-Binding Peptide OP3-4 Promotes BMP-2-Induced Maxillary Bone Regeneration. J. Dent. Res.. 2016.03; ( PubMed, DOI )

Moe Htet, Marwa Madi, Ossama Zakaria, Takayuki Miyahara, Wang Xin, Zayar Lin, Kazuhiro Aoki, Shohei Kasugai. Decontamination of Anodized Implant Surface with Different Modalities for Peri-Implantitis Treatment: Lasers and Mechanical Debridement with Citric Acid. J. Periodontol.. 2016.03; 1-17. ( PubMed, DOI )

Trang N Nguyen Vo, Jia Hao, Josh Chou, Masamitsu Oshima, Kazuhiro Aoki, Shinji Kuroda, Boosana Kaboosaya, Shohei Kasugai. Ligature induced peri-implantitis: tissue destruction and inflammatory progression in a murine model. Clin Oral Implants Res. 2016.01; ( PubMed, DOI )

Natsuki Suzuki, Kazuhiro Aoki, Petr Marcián, Libor Borák, Noriyuki Wakabayashi. A threshold of mechanical strain intensity for the direct activation of osteoblast function exists in a murine maxilla loading model. Biomech Model Mechanobiol. 2015.11; ( PubMed, DOI )

Mohannad Nassar, Noriko Hiraishi, Yukihiko Tamura, Masayuki Otsuki, Kazuhiro Aoki, Junji Tagami. Phytic Acid: An Alternative Root Canal Chelating Agent. J Endod. 2015.02; 41 (2): 242-247. ( PubMed, DOI )

Masahiro Chatani, Akiko Mantoku, Kazuhiro Takeyama, Dawud Abduweli, Yasutaka Sugamori, Kazuhiro Aoki, Keiichi Ohya, Hiromi Suzuki, Satoko Uchida, Toru Sakimura, Yasushi Kono, Fumiaki Tanigaki, Masaki Shirakawa, Yoshiro Takano, Akira Kudo. Microgravity promotes osteoclast activity in medaka fish reared at the international space station. Sci Rep. 2015; 5 14172. ( PubMed, DOI )

Genki Kato, Yasuhiro Shimizu, Yuki Arai, Natsuki Suzuki, Yasutaka Sugamori, Miki Maeda, Mariko Takahashi, Yukihiko Tamura, Noriyuki Wakabayashi, Ramachandran Murali, Takashi Ono, Keiichi Ohya, Setsuko Mise-Omata, Kazuhiro Aoki. The inhibitory effects of a RANKL-binding peptide on articular and periarticular bone loss in a murine model of collagen-induced arthritis: a bone histomorphometric study. Arthritis Res. Ther. 2015; 17 (1): 251. ( PubMed, DOI )

Toshimi Sato, Neil Alles, Masud Khan, Kenichi Nagano, Mariko Takahashi, Yukihiko Tamura, Asako Shimoda, Keiichi Ohya, Kazunari Akiyoshi, Kazuhiro Aoki. Nanogel-crosslinked nanoparticles increase the inhibitory effects of W9 synthetic peptide on bone loss in a murine bone resorption model. Int J Nanomedicine. 2015; 10 3459-3473. ( PubMed, DOI )

Mise-Omata S. Alles N. Fukazawa T. Aoki K. Ohya K. Jimi E. Obata Y. Doi T. NF-κB RELA-deficient bone marrow macrophages fail to support bone formation and to maintain the hematopoietic niche after lethal irradiation and stem cell transplantation. Int. Immunol. 2014.11; 26 (11): 607-618. ( PubMed, DOI )

Aoki K. Maeda M. Nakae T. Okada Y. Ohya K. Chiba K. A disulfide bond replacement strategy enables the efficient design of artificial therapeutic peptides. Tetrahedron. 2014.10; 70 7774-7779. ( DOI )

Kimura A. Kabasawa Y. Tabata Y. Aoki K. Ohya K. Omura K. Gelatin hydrogel as a carrier of recombinant human fibroblast growth factor-2 during rat mandibular distraction. J. Oral Maxillofac. Surg. 2014.10; 72 (10): 2015-2031. ( PubMed, DOI )

Tada Y. Kokabu S. Sugiyama G. Nakatomi C. Aoki K. Fukushima H. Osawa K. Sugamori Y. Ohya K. Okamoto M. Fujikawa T. Itai A. Matsuo K. Watanabe S. Jimi E. The novel IκB kinase β inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma. Oncotarget. 2014.10; ( PubMed )

Hirata-Tsuchiya S. Fukushima H. Katagiri T. Ohte S. Shin M. Nagano K. Aoki K. Morotomi T. Sugiyama G. Nakatomi C. Kokabu S. Doi T. Takeuchi H. Ohya K. Terashita M. Hirata M. Kitamura C. Jimi E. Inhibition of BMP2-induced bone formation by the p65 subunit of NF-κB via an interaction with Smad4. Mol. Endocrinol. 2014.09; 28 (9): 1460-1470. ( PubMed, DOI )

Negishi N. Suzuki D. Ito R. Irie N. Matsuo K. Yahata T. Nagano K. Aoki K. Ohya K. Hozumi K. Ando K. Tamaoki N. Ito M. Habu S. Effective expansion of engrafted human hematopoietic stem cells in bone marrow of mice expressing human Jagged1. Exp. Hematol. 2014.06; 42 (6): 487-94.e1. ( PubMed, DOI )

Kaori Shoi, Kazuhiro Aoki, Keiichi Ohya, Yuzo Takagi, Hitoyata Shimokawa. Characterization of pulp and follicle stem cells from impacted supernumerary maxillary incisors. Pediatr Dent. 2014.05; 36 (3): 79-84. ( PubMed )

Yoshie Nagai, Kenji Osawa, Hidefumi Fukushima, Yukihiko Tamura, Kazuhiro Aoki, Keiichi Ohya, Hisataka Yasuda, Hisako Hikiji, Mariko Takahashi, Yuji Seta, Sachiko Seo, Mineo Kurokawa, Shigeaki Kato, Hiroaki Honda, Ichiro Nakamura, Kenshi Maki, Eijiro Jimi. p130Cas, Crk-associated substrate, plays important roles in osteoclastic bone resorption. J. Bone Miner. Res.. 2013.12; 28 (12): 2449-2462. ( PubMed, DOI )

Wannakorn Sriarj, Kazuhiro Aoki, Keiichi Ohya, Mariko Takahashi, Yuzo Takagi, Hitoyata Shimokawa. TGF-β in dentin matrix extract induces osteoclastogenesis in vitro. Odontology. 2013.12; ( PubMed, DOI )

Hitomi Nakamura, Kazuhiro Aoki, Wataru Masuda, Neil Alles, Kenichi Nagano, Hidefumi Fukushima, Kenji Osawa, Hisataka Yasuda, Ichiro Nakamura, Yuko Mikuni-Takagaki, Keiichi Ohya, Kenshi Maki, Eijiro Jimi. Disruption of NF-κB1 prevents bone loss caused by mechanical unloading. J. Bone Miner. Res.. 2013.06; 28 (6): 1457-1467. ( PubMed, DOI )

Fujiki K. Aoki K. Marcian P. Borak L. Hudieb M. Ohya K. Igarashi Y. Wakabayashi N.. The influence of mechanical stimulation on osteoclast localization in the mouse maxilla: bone histomorphometry and finite element analysis. Biomechanics and Modeling in Mechanobiology . 2013; 12 (2): 325-333. ( DOI )

Khan, M. Alles, N. Soysa, N. Mamun, A. Nagano, K. Mikami, R. Furuya, Y. Yasuda, H. Ohya, K. Aoki, K. The local administration of TNF-a and RANKL antagonist peptide promotes BMP-2-induced bone formation. J Oral Biosciences . 2013; 55 47-54. ( DOI )

Mamun, A. Khan, M. Alles, N. Matsui, M. Tabata, Y. Ohya, K. Aoki, K. Gelatin hydrogel carrier with the W9-peptide elicits synergistic effects on BMP-2-induced bone regeneration. J Oral Biosciences . 2013; 55 217-223. ( DOI )

Furuya,Y. Inagaki, A. Khan, M. Mori, K. Penninger, J.M. Nakamura, M. Udagawa, N. Aoki, K. Ohya, K. Uchida, K. Yasuda, H. Stimulation of bone formation in cortical bone of mice treated with a receptor activator of nuclear factor-κB ligand (RANKL)-binding peptide that possesses osteoclastogenesis inhibitory activity. J Biol Chem . 2013; 288 (8): 5562-5571. ( DOI )

Aoki Kazuhiro, Alles Neil, Soysa Niroshani, Ohya Keiichi. Peptide-based delivery to bone. Adv Drug Deliv Rev. 2012.09; 64 (12): 1220-1238. ( PubMed, DOI )

Hiroyuki Furuta, Kenji Osawa, Masashi Shin, Ayataka Ishikawa, Kou Matsuo, Masud Khan, Kazuhiro Aoki, Keiichi Ohya, Masato Okamoto, Kazuhiro Tominaga, Tetsu Takahashi, Osamu Nakanishi, Eijiro Jimi. Selective inhibition of NF-κB suppresses bone invasion by oral squamous cell carcinoma in vivo. Int. J. Cancer. 2012.09; 131 (5): E625-E635. ( PubMed, DOI )

Hiroyuki Nakachi, Kazuhiro Aoki, Nobuyoshi Tomomatsu, Neil Alles, Kenichi Nagano, Masashi Yamashiro, Hongtao Zhang, Ramachandran Murali, Mark I Greene, Keiichi Ohya, Teruo Amagasa. A structural modulator of tumor necrosis factor type 1 receptor promotes bone formation under lipopolysaccharide-induced inflammation in a murine tooth extraction model. Eur. J. Pharmacol.. 2012.03; 679 (1-3): 132-138. ( PubMed, DOI )

Yoshinori Seo, Hidefumi Fukushima, Toshimasa Maruyama, Kayoko Nakao Kuroishi, Kenji Osawa, Kenichi Nagano, Kazuhiro Aoki, Falk Weih, Takahiro Doi, Min Zhang, Keiichi Ohya, Takenobu Katagiri, Ryuji Hosokawa, Eijiro Jimi. Accumulation of p100, a precursor of NF-κB2, enhances osteoblastic differentiation in vitro and bone formation in vivo in aly/aly mice. Mol. Endocrinol.. 2012.03; 26 (3): 414-422. ( PubMed, DOI )

林 直毅, 田村 幸彦, 楠本 康香, 下川 仁彌太, 青木 和広, 大谷 啓一, 山崎 統資, 篠塚 修. フェニトインによる歯肉増殖について　ヒト歯肉組織およびクローン歯肉細胞に関する研究. 障害者歯科. 2012.02; 33 (1): 16-26. ( ichushi )

Soysa Niroshani Surangika, Alles Neil, Aoki Kazuhiro, Ohya Keiichi. Osteoclast formation and differentiation: an overview. J Med Dent Sci. 2012; 59 (3): 65-74. ( PubMed )

Kenichi Nagano, Neil Alles, Anower Hussain Mian, Asako Shimoda, Nobuyuki Morimoto, Yukihiko Tamura, Hitoyata Shimokawa, Kazunari Akiyoshi, Keiichi Ohya, Kazuhiro Aoki. The tumor necrosis factor type 2 receptor plays a protective role in tumor necrosis factor-α-induced bone resorption lacunae on mouse calvariae. J. Bone Miner. Metab.. 2011.11; 29 (6): 671-681. ( PubMed, DOI )

Soysa N S, Alles N, Takahashi M, Aoki K, Ohya K. Defective nuclear factor-kappaB-inducing kinase in aly/aly mice prevents bone resorption induced by local injection of lipopolysaccharide. J Periodontal Res. 2011.04; 46 (2): 280-284. ( PubMed, DOI )

Alles Neil, Soysa Niroshani S, Hayashi Juri, Khan Masud, Shimoda Asako, Shimokawa Hitoyata, Ritzeler Olaf, Akiyoshi Kazunari, Aoki Kazuhiro, Ohya Keiichi. Suppression of NF-kappaB increases bone formation and ameliorates osteopenia in ovariectomized mice. Endocrinology. 2010.10; 151 (10): 4626-4634. ( PubMed, DOI )

Takato Inokuchi, Tatsuo Kawamoto, Kazuhiro Aoki, Asato Aoki, Kouhei Nagahama, Yoshiyuki Baba, Syouichi Suzuki, Masaharu Shibayama, Yoshihiro Mano, Keiichi Ohya, Keiji Moriyama. The effects of hyperbaric oxygen on tooth movement into the regenerated area after distraction osteogenesis. Cleft Palate Craniofac. J.. 2010.07; 47 (4): 382-392. ( PubMed, DOI )

Asato Aoki, Tatsuo Kawamoto, Kazuhiro Aoki, Takato Inokuchi, Atsuo Kudoh, Kouhei Nagahama, Yoshiyuki Baba, Syouichi Suzuki, Keiichi Ohya, Keiji Moriyama. Amount of bone lengthening affects blood flow recovery and bone mineralization after distraction osteogenesis in a canine cleft palate model. Cleft Palate Craniofac. J.. 2010.05; 47 (3): 303-313. ( PubMed, DOI )

Soysa Niroshani S, Alles Neil, Weih Debra, Lovas Agnes, Mian Anower Hussain, Shimokawa Hitoyata, Yasuda Hisataka, Weih Falk, Jimi Eijiro, Ohya Keiichi, Aoki Kazuhiro. The pivotal role of the alternative NF-kappaB pathway in maintenance of basal bone homeostasis and osteoclastogenesis. J Bone Miner Res. 2010.04; 25 (4): 809-818. ( PubMed, DOI )

Okamoto K, Iwai Y, Oh-Hora M, Yamamoto M, Morio T, Aoki K, Ohya K, Jetten AM, Akira S, Muta T, Takayanagi H. IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors. Nature. 2010.04; 464 (7293): 1381-1385. ( PubMed, DOI )

Higuchi Y, Kabasawa Y, Sato M, Kikuchi T, Aoki K, Ohya K, Maruoka Y, Omura K. Effect of recombinant human fibroblast growth factor-2 on bone formation in rabbit mandibular distraction models using beta-tricalcium phosphate. Congenit Anom (Kyoto). 2010.02; ( PubMed, DOI )

Nakalekha C, Yokoyama C, Miura H, Alles N, Aoki K, Ohya K, Morita I. Increased bone mass in adult prostacyclin-deficient mice. J Endocrinol. 2010.02; 204 (2): 125-133. ( PubMed, DOI )

Maruyama T, Fukushima H, Nakao K, Shin M, Yasuda H, Weih F, Doi T, Aoki K, Alles N, Ohya K, Hosokawa R, Jimi E. Processing of the NF-kappaB2 Precursor, p100, to p52 is Critical for RANKL-Induced Osteoclast Differentiation. J Bone Miner Res. 2009.10; ( PubMed, DOI )

Tomomatsu Nobuyoshi, Aoki Kazuhiro, Alles Neil, Soysa Niroshani S, Hussain Anower, Nakachi Hiroyuki, Kita Souma, Shimokawa Hitoyata, Ohya Keiichi, Amagasa Teruo. LPS-induced inhibition of osteogenesis is TNF-alpha dependent in a murine tooth extraction model. J Bone Miner Res. 2009.10; 24 (10): 1770-1781. ( PubMed, DOI )

Soysa Niroshani Surangika, Alles Neil, Aoki Kazuhiro, Ohya Keiichi. Three-dimensional characterization of osteoclast bone-resorbing activity in the resorption lacunae. J Med Dent Sci. 2009.09; 56 (3): 107-112. ( PubMed )

Aoki K. Applications and the Future of Peptide Drugs for Inflammatory Bone Resorption. J Oral Biosci. 2009.06; 51 119-133.

Alles Neil, Soysa Niroshani S, Hussain M D Anower, Tomomatsu Nobuyoshi, Saito Hiroaki, Baron Roland, Morimoto Nobuyuki, Aoki Kazuhiro, Akiyoshi Kazunari, Ohya Keiichi. Polysaccharide nanogel delivery of a TNF-alpha and RANKL antagonist peptide allows systemic prevention of bone loss. Eur J Pharm Sci. 2009.05; 37 (2): 83-88. ( PubMed, DOI )

Onizawa M, Nagaishi T, Kanai T, Nagano K, Oshima S, Nemoto Y, Yoshioka A, Totsuka T, Okamoto R, Nakamura T, Sakamoto N, Tsuchiya K, Aoki K, Ohya K, Yagita H, Watanabe M. Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis. Am J Physiol Gastrointest Liver Physiol. 2009.04; 296 (4): G850-9. ( PubMed, DOI )

Sriarj W, Aoki K, Ohya K, Takagi Y, Shimokawa H. Bovine dentine organic matrix down-regulates osteoclast activity. J Bone Miner Metab. 2009; 27 (3): 315-323. ( PubMed, DOI )

Soysa Niroshani S, Alles Neil, Shimokawa Hitoyata, Jimi Eijiro, Aoki Kazuhiro, Ohya Keiichi. Inhibition of the classical NF-kappaB pathway prevents osteoclast bone-resorbing activity. J Bone Miner Metab. 2009; 27 (2): 131-139. ( PubMed, DOI )

Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, Nishikawa K, Latz E, Golenbock DT, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H. Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science. 2008.02; 319 (5863): 624-627. ( PubMed, DOI )

Hussain Mian A, Saito H, Alles N, Shimokawa H, Aoki K, Ohya K. Lipopolysaccharide-induced bone resorption is increased in TNF type 2 receptor-deficient mice in vivo. (Corresponding author). J Bone Miner Metab. 2008; 26 (5): 469-477. ( PubMed, DOI )

Gil-Henn H, Destaing O, Sims NA, Aoki K, Alles N, Neff L, Sanjay A, Bruzzaniti A, De Camilli P, Baron R, Schlessinger J. Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice. J Cell Biol. 2007.09; 178 (6): 1053-1064. ( PubMed, DOI )

Saito H, Kojima T, Takahashi M, Horne WC, Baron R, Amagasa T, Ohya K, Aoki K. A tumor necrosis factor receptor loop peptide mimic inhibits bone destruction to the same extent as anti-tumor necrosis factor monoclonal antibody in murine collagen-induced arthritis. (Corresponding author). Arthritis Rheum. 2007.04; 56 (4): 1164-1174. ( PubMed, DOI )

Kubota T, Hoshino M, Aoki K, Ohya K, Komano Y, Nanki T, Miyasaka N, Umezawa K. NF-kappaB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor. Arthritis Res Ther. 2007; 9 (5): R97. ( PubMed, DOI )

Sato K, Suematsu A, Nakashima T, Takemoto-Kimura S, Aoki K, Morishita Y, Asahara H, Ohya K, Yamaguchi A, Takai T, Kodama T, Chatila TA, Bito H, Takayanagi H. Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Med. 2006.12; 12 (12): 1410-1416. ( PubMed, DOI )

Kamijo S, Nakajima A, Ikeda K, Aoki K, Ohya K, Akiba H, Yagita H, Okumura K. Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody. Biochem Biophys Res Commun. 2006.08; 347 (1): 124-132. ( PubMed, DOI )

Aoki K, Saito H, Itzstein C, Ishiguro M, Shibata T, Blanque R, Mian AH, Takahashi M, Suzuki Y, Yoshimatsu M, Yamaguchi A, Deprez P, Mollat P, Murali R, Ohya K, Horne WC, Baron R. A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss. J Clin Invest. 2006.06; 116 (6): 1525-1534. ( PubMed, DOI )

Suzuki Y, Aoki K, Saito H, Umeda M, Nitta H, Baron R, Ohya K. A tumor necrosis factor-alpha antagonist inhibits inflammatory bone resorption induced by Porphyromonas gingivalis infection in mice. (Corresponding author). J Periodontal Res. 2006.04; 41 (2): 81-91. ( PubMed, DOI )

Nonaka K, Fukuda S, Aoki K, Yoshida T, Ohya K. Regional distinctions in cortical bone mineral density measured by pQCT can predict alterations in material property at the tibial diaphysis of the Cynomolgus monkey. Bone. 2006.02; 38 (2): 265-272. ( PubMed, DOI )

Saito H, Soysa N, Alles N, Aoki K, Ohya K. Three-Dimensional Measurements of Bone Resorption Lacunae Reveal Inhibition of Osteoclast Activity by TNF-α Antagonist In Vitro. Dentistry in Japan. 2006; 42 35-37.

Varghese BJ, Aoki K, Shimokawa H, Ohya K, Takagi Y. Bovine deciduous dentine is more susceptible to osteoclastic resorption than permanent dentine: results of quantitative analyses. J Bone Miner Metab. 2006; 24 (3): 248-254. ( PubMed, DOI )

Aoki K, Ohya K. [RANKL/RANK signaling-inhibitor] Nippon Rinsho. 2005.09; 63 (9): 1620-1626. ( PubMed )

Takatsuna H, Asagiri M, Kubota T, Oka K, Osada T, Sugiyama C, Saito H, Aoki K, Ohya K, Takayanagi H, Umezawa K. Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-kappaB inhibitor, through downregulation of NFATc1. J Bone Miner Res. 2005.04; 20 (4): 653-662. ( PubMed, DOI )

Kojima T, Aoki K, Nonaka K, Saito H, Azuma M, Iwai H, Varghese BJ, Yoshimasu H, Baron R, Ohya K, Amagasa T. Subcutaneous injections of a TNF-alpha antagonistic peptide inhibit both inflammation and bone resorption in collagen-induced murine arthritis. (Corresponding author). J Med Dent Sci. 2005.03; 52 (1): 91-99. ( PubMed )

Tint K, Kondo H, Kuroda S, Fujimori T, Aoki K, Ohya K, Kasugai S. Effectiveness of Extracted-teeth as Bone Substitute: Application to Parietal Bone Defects in Rabbits. J Oral Tissue Engin. 2005; 3 (1): 7-16.

Nagahama K, Aoki K, Nonaka K, Saito H, Takahashi M, Varghese BJ, Shimokawa H, Azuma M, Ohya K, Ohyama K. The deficiency of immunoregulatory receptor PD-1 causes mild osteopetrosis. (Corresponding author). Bone. 2004.11; 35 (5): 1059-1068. ( PubMed, DOI )

Damrongrungruang T, Kuroda S, Kondo H, Aoki K, Ohya K, Kasugai S. A simple murine model for immobilization osteopenia. Clin Orthop Relat Res. 2004.08; (425): 244-251. ( PubMed )

Jimi E, Aoki K, Saito H, D'Acquisto F, May MJ, Nakamura I, Sudo T, Kojima T, Okamoto F, Fukushima H, Okabe K, Ohya K, Ghosh S. Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med. 2004.06; 10 (6): 617-624. ( PubMed, DOI )

Asawa Y, Aoki K, Ohya K, Ohshima H, Takano Y. Appearance of electron-dense segments: indication of possible conformation changes of pre-mineralizing collagen fibrils in the osteoid rat bones. J Electron Microsc. 2004; 53 423-433.

Aoki K, Ohya K. [The mechanism of osteoprosis revealed by the animal studies: the involvement of alveolar bone resorption induced by the periodontal disease] Clin Calcium. 2003.05; 13 (5): 587-593. ( PubMed )

Kitasako Y, Nakajima M, Foxton RM, Aoki K, Pereira PN, Tagami J. Physiological remineralization of artificially demineralized dentin beneath glass ionomer cements with and without bacterial contamination in vivo. Oper Dent. 2003.05; 28 (3): 274-280. ( PubMed )

Horie D, Takahashi M, Aoki K, Ohya K. Clodronate stimulates bone formation as well as inhibits bone resorption and increases bone mineral density in rats fed a low-calcium diet. J Med Dent Sci. 2003.03; 50 (1): 121-132. ( PubMed )

Kuroda S, Mukohyama H, Kondo H, Aoki K, Ohya K, Ohyama T, Kasugai S. Bone mineral density of the mandible in ovariectomized rats: analyses using dual energy X-ray absorptiometry and peripheral quantitative computed tomography. Oral Dis. 2003.01; 9 (1): 24-28. ( PubMed )

Takahashi E, Mukohyama H, Aoki K, Duarte WR, Lerner UH, Ohya K, Omura K, Kasugai S. High extracellular calcium affects osteoclastogenesis in mouse bone marrow cell culture. J Med Dent Sci. 2002.12; 49 (4): 109-120. ( PubMed )

Aoki K, Ohya K. [The drug treatment for bone resorption in the oral area] Clin Calcium. 2002.07; 12 (7): 997-1003. ( PubMed )

Yamazoe T, Aoki K, Simokawa H, Ohya K, Takagi Y. Gene expression of bone matrix proteins in a calcified tissue appeared in subcutaneously transplanted rat dental pulp. J Med Dent Sci. 2002.03; 49 (1): 57-66. ( PubMed )

Juji T, Hertz M, Aoki K, Horie D, Ohya K, Gautam A, Mouritsen S, Oda H, Nakamura K, Tanaka S. A novel therapeutic vaccine approach, targeting RANKL, prevents bone destruction in bone-related disorders. J Bone Miner Metab. 2002; 20 (5): 266-268. ( PubMed, DOI )

Nakamura H, Morita S, Kumei Y, Aoki K, Shimokawa H, Ohya K, Shinomiya KI. Effects of neurectomy and tenotomy on the bone mineral density and strength of tibiae. Acta Astronaut. 2001.08; 49 (3-10): 179-190. ( PubMed )

Sabatakos G, Sims NA, Chen J, Aoki K, Kelz MB, Amling M, Bouali Y, Mukhopadhyay K, Ford K, Nestler EJ, Baron R. Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis. Nat Med. 2000.09; 6 (9): 985-990. ( PubMed, DOI )

Noji H, Yoshimasu H, Aoki K, Ohya K, Amagasa T. Non-invasive densitometric and histomorphometric study of the regenerated bone in the distraction gap in rabbits. J Med Dent Sci. 2000.09; 47 (3): 197-207. ( PubMed )

Iwasa Y, Shimoyama K, Aoki K, Ohya K, Uematsu H. The effect of high salt intake on the mandibular bone loss in Dahl-Iwai salt-sensitive rat. J Med Dent Sci. 2000.09; 47 (3): 187-195. ( PubMed )

Seto H, Aoki K, Kasugai S, Ohya K. Trabecular bone turnover, bone marrow cell development, and gene expression of bone matrix proteins after low calcium feeding in rats. Bone. 1999.12; 25 (6): 687-695. ( PubMed )

Aoki K, Didomenico E, Sims NA, Mukhopadhyay K, Neff L, Houghton A, Amling M, Levy JB, Horne WC, Baron R. The tyrosine phosphatase SHP-1 is a negative regulator of osteoclastogenesis and osteoclast resorbing activity: increased resorption and osteopenia in me(v)/me(v) mutant mice. Bone. 1999.09; 25 (3): 261-267. ( PubMed )

Suzuki K, Aoki K, Ohya K. Effects of surface roughness of titanium implants on bone remodeling activity of femur in rabbits. Bone. 1997.12; 21 (6): 507-514. ( PubMed )

Ogawara M, Aoki K, Okiji T, Suda H. Effect of ascorbic acid deficiency on primary and reparative dentinogenesis in non-ascorbate-synthesizing ODS rats. Arch Oral Biol. 1997.10; 42 (10-11): 695-704. ( PubMed )

Kaneko H, Koyama T, Asou T, Aoki K, Ohya K. The effect of HACHIMI-JIO-GAN, a kanpo metabolism of rats treated by GnRH agonist. (in Japanese). J Jpn Menopanse Soc. 1995; 3 225-232.

Ohya K, Yausi M, Oda T, Aoki K, Ogura H. Morphological observations of the hard tissues with the confocal laser scanning microscope.(in Japanese). J Oral Biosci. 1992; 34 339-349.

Aoki K. Differential Response in the Cortical and the Cancellous regions of Tibia to a low Calcium feeding in rats : A Histomorphometric Study.(First Author). J Oral Biosci. 1992; 34 (5): 595-611.

Preksa Keo, Yoshiro Matsumoto, Shigeki Nagahiro, Kazuhrio Aoki, Takashi Ono. Time-course study of bones induced by the co-injection of RANKL-binding peptide and BMP-2 and the effects of subsequent screw placement in murine maxilla. The 61st Annual Meeting of Japanese Association for Oral Biology 2019.10.01 Tokyo、Japan

Ayaka Urakawa, Masud Khan, Yosuke Sasaki, Michiko Ozawa, Kazunari Akiyoshi, and Kazuhiro Aoki. An investigation of scaffold materials suitable for new bone anabolic agents. 1st Meeting of the International Oral Engineering Consortium 2018.09.24 Tokyo, Japan

N. Wakabayashi, H. Inagawa, N. Suzuki, K. Aoki, T. Yamazaki, C. Watanabe, N. Murakami.. Validity of Young's Modulus Estimated Based on Computed Tomography. 96th General Session & Exhibition of the IADR 2018.07.28 London, England

Kazuhiro AOKI. Roland gave me a seed of my research. The 59th Annual Meeting of Japanese Association for Oral Biology 2017.09.16 Matsumoto Dental University

Mikami R, Aoki A, Mizutani K, Tamura Y, Aoki K, Izumi Y. Low-level blue laser irradiation enhances osteoblast proliferation and differentiation. The 102nd Annual Meeting of the American Academy of Periodontology 2016.09.10 San Diego Convention Center(USA)

Md.Zahirul Haque Bhuyan, Chizuko Maeda, Yuki Yoshinari, Marin Kawasaki, Yasutaka Sugamori, Genki Kato, Mariko Takahashi, Yukihiko Tamura, Kazuhiro Aoki. The therapeutic effects of the RANKL-binding peptides on cartilage destruction.. 13th Bone Biology Forum 2016.08.20 Cross Wave Makuhari (Chiba)

Yukihiko Tamura, Setsuko Mise, Yasutaka Sugamori, Md. Zahirul Haq Bhuyan, Mariko Takahashi, Tomoki Uehara, Yuki Arai, Michiyo Miyashin, Noriyuki Wakabayashi, Kazuhiro Aoki. A pharmacological role of metallothionein in zinc-treated cartilage-progenitor cells. APFP 2016(The 13th Asia Pacific Federation of Pharmacologists Meeting) 2016.02.01

Md. Zahirul Haque Bhuyan, Yoshinari Y, Kawasaki M, Sugamori Y, Kato G, Takahashi M, Tamura Y, Aoki K. The preliminary results on the effects of RANKL-binding peptide of cartilage destruction.. 12th Bone Biology Forum 2015.08.21 Chiba（Cross Wave Makuhari）

Uehara T, Mise S, Arai Y, Sugamori Y, Kato G, Tamura Y, Tabata Y, Murali R, Wakabayashi N, Miyashin M, Aoki K. A rankl-binding peptide accelerates BMP-induced bone regeneration in murine maxilla by subperiosteal injections.. 13th Congress of the Internatitonal Society of Bone Morphometry 2015.04.27 Tokyo(Tokyo Garden Palace Hotel)

Sugamori Y, HonmaＭ, Kato G, Tamura Y, Furuya Y, Yasuda H, Tabata Y, Udagawa N, Ohya K, Suzuki H, Aoki K. RANKL-binding peptides increased bone formation in a murine calvarial defect model. ASBMR2014 2014.09.12 Houston, Texas, USA

Chatani M, Mantoku A, Takeyama K, Aoki K, Sugamori Y, Ohya K, Uchida S, Suzuki H, Sakimura T, Kono Y,Tanigaki F, Shirakawa M, Inohaya K, Abduweri D, Takano Y, Kudo A. Rearing Medaka Fish in International Space Station (ISS) for Bone Metabolism Study. ASBMR2014 2014.09.12 Houston, Texas, USA

Nagano T, Mukai Y, Sugamori Y, Kato G, Ohya K, Aoki K, Higashisaka K, Yoshioka Y, Nagano K, Kamada H, Tsunoda S, Tsutsumi Y.. Basic analysis for screening a novel bone-regenerating peptide from the phage peptide library. CRS2014 2014.07.12 Chicago, USA

Kato G. Shimizu Y. Mamun M. Murali R. Ohya K. Aoki K. An Osteoprotegerin-like Peptide Prevents Bone Loss in Collagen-Induced Murine Arthritis. The 3rd Tri-University Consortium on Oral Science and Education 2013.11.06 Tokyo

Aoki K. Murali R. Ohya K. Bone resorption inhibitor peptides work as a bone formation stimulator. The 3rd Tri-University Consortium on Oral Science and Education 2013.11.06 Tokyo

Fujiki K. Wakabayashi N. Suzuki N. Borak L. Ohya K. Aoki K.. The involvement of tumor necrosis factor-a in osteoclast differentiation induced by mechanical stress in a murine maxilla loading model. ASBMR 2013（米国骨代謝学会） 2013.10.04 Baltimore(USA)

Aoki K. The bone resorption inhibitor peptide promotes bone formation by a reverse signaling pathway. Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical Center 2013.10.03 Los Angeles(USA)

中村 美どり、宇田川 信之、青木 和広、大谷 啓一. W9 ペプチドの破骨細胞形成抑制作用と骨芽細胞分化促進作用. 第55回歯科基礎医学会学術大会 2013.09.20 岡山市

Suzuki N. Fujiki K. Ohya K. Aoki K. Wakabayashi N. Inflammation Accelerates Mechanical-Stress-Induced Osteoclastogenesis in a Murine Maxilla Loading Model. 2013 2nd Meeting of the IADR Asian Pacific Region. 2013.08.21 Thailand

Aoki K. The recent development of therapeutic peptide candidates for bone disease. 2nd International Conference on Translational & Personalized Medicine 2013.08.05 Chicago, USA

Kato, G. Maeda, M. Alles, N. Mamun, A. Khan, M. Sugamori, Y. Takahashi, M. Tamura, Y. Murali, R. Ohya, K. Aoki, K. An Osteoprotegerin-like Peptide Inhibits Bone Loss in Collagen Type II-Induced Murine Arthritis. IBMS/JSBMR第2回合同国際会議 2013.05.28 神戸市

Mamun, A. Khan, M. Alles, N. Tamura, Y. Matsui, M. Tabata, Y. Ohya, K. Aoki, K. Bone Regeneration Using Gelatin Hydrogel as a Novel Scaffold for a RANKL Antagonist Peptide W9. 第12回日本再生医療学会総会 2013.03.21 横浜市

Khan, M. Alles, N. Soysa, N. Mamun, A. Nagano, K. Mikami, R. Furuya, Y. Yasuda, H. Ohya, K. Aoki,K. A Small Peptide Inhibitor of Inflammatory Bone Resorption Promotes BMP-2-Induced Bone Formation. 第86回日本薬理学会年会 2013.03.21 福岡市

Khan M, Alles N, Mamun A, Nakamura M, Furuya Y, Yasuda H, Udagawa N, Ohya K, Aoki K. TNF-a Antagonist Peptide Increases Ectopic Bone Formation under RANKL-Dependent Mechanism. 66thJADR 2012.12.14 Nigata

Alles N, Soysa N.S, Khan M, Mamun A, Furuya Y, Yasuda H, Ohya K, Aoki K. Bone Resorption Inhibitory peptide Repairs Critical Size Defect on Calvariae in Mice. ASBMR2012 2012.10.12 Minneapolis USA

Furuya Y, Khan M, Inagaki A, Mori K, Aoki K, Ohya K, Uchida K, Yasuda H. Mechanism Analysis of a Novel Bone Anabolic Peptide. ASBMR2012 2012.10.12 Minneapolis USA

Mamun A、Khan M、Alles N、田村幸彦、大谷啓一、青木和広. BMP誘導骨再生におけるゼラチンのペプチド担体としての有用性. 第54回歯科基礎医学会学術大会 2012.09.14 郡山

Khan M, Alles N, Mamun A, Nagano K, Ohya K, Aoki K.. RANKL-Mediated Bone Formation By TNF-alpha Antagonist Peptide. IADR GENERAL SESSION 2012.06.18 Iguacu Falls BRAZIL

M.KHAN, N.ALLES, A.MAMUN, Y.FURUYA, H.YASUDA, J.PENNINGER, A.ARAI, M.NAKAMURA, T. MIZOGUCHI, N.TAKAHASHI, N.UDAGAWA, K.OHYA, K.AOKI. A Bone Resorption Inhibitor Promotes Bone Formation. 第59回国際歯科研究学会日本部会(JADR)総会・学術大会 2011.10.08 広島

KHAN M, ALLES N, NAGANO K, FURUYA Y, YASUDA H, OHYA K, AOKI K. Both TNF-α and RANKL Antagonist Peptide Stimulates Bone Formation in TNF-α Deficient Mice to the Same Extent as in Wild Type Mice. ASBMR2011 2011.09.16 San Diego, CA, USA

カーン・マスード、アレス・ニール、永野健一、古屋優里子、保田尚孝、大谷啓一、青木和広. TNF-α拮抗ペプチドはTNF-α非依存的に骨形成を亢進する. 第29回日本骨代謝学会学術大会 2011.07.28 大阪

M.KHAN、N.ALLES、永野健一、大谷啓一、青木和広. The stimulatory effects of TNF-α and RANKL antagonist peptide W9 on bone formation. 第31回日本骨形態計測学会 2011.05.20 岐阜

Khan M, Aoki K, Yamaguchi A, Ohya K. The effects of RANKL Antagonist Peptide on Bone Formation. 第58回JADR学術大会 2010.11.20 北九州市

Khan Masud、青木和広、大谷啓一. A small peptide preventing inflammatory bone resorption promotes bone formation. 2010.09.20 東京

Srirj W, Aoki K, Ohya K, Takagi Y, Shimokawa H. Factors in Dentine Organic Matrices Influence Osteoclastogenesis. 88th IADR General Session 2010.07.14 Barcelona, Spain

Inokuchi T, Kawamoto T, Aoki K, Itoh Y, Ominaga N, Baba Y, Suzuki S, Ohya K, Moriyama K. Effects of Hyperbaric Oxygen on Tooth Movement after Distraction Osteogenesis. 88th IADR General Session 2010.07.14 Barcelona, Spain

Soysa N, Alles N, Hayashi J, Khan M, Shimokawa H, Aoki K, Ohya K. Pharmacological Inhibition of NF-kB for Bone Formation in vitro and in vivo. 88th IADR General Session 2010.07.14 Barcelona, Spain

Hirata S, Fukushima H, Morotomi T, Aoki K, Nagano K, Kitamura C, Terashima M, Jimi E. Inhibition of NF-kB enhances BMP-induced bone formation. 88th IADR General Session 2010.07.14 Barcelona, Spain

Nagano K, Aoki K, Alles N, Ohya K. The protective role of TNFR2 on TNF-a-induced bone resorption. 88th IADR General Session 2010.07.14

Ohya K, Soysa N, Alles N, Aoki K. Inhibition of IKK-b blocks osteoclast formation and activity. 1st meeting of the IADR APR 2009.09.22 武漢（中国)

福島秀文、進正史、丸山俊正、青木和広、大谷啓一、細川隆司、自見英治郎. NF-kB 非古典的経路における破骨細胞分化調節機構. 第51回歯科基礎医学会学術大会ならびに総会 2009.09.09 新潟

永野健一、青木和広、Neil Alles、大谷啓一. TNF-a 誘導の骨吸収に対するTNFR2の役割. 第51回歯科基礎医学会学術大会ならびに総会 2009.09.09 新潟

Soysa N, Alles N, Aoki K, Ohya K. Lack of precursor p100 of NFkB2 causes osteopenia in mice. 第29回骨形態計測学会 2009.05.28

Nagano K, Aoki K, Mian A.H, Alles N, Shimoda A, Morimoto N, Akiyoshi K, Ohya K.. NF-a-induced bone resorption model using CHP nanogel in mice. Japanese Association for Dental Research 56th Annual Meeting 2008.11.29

Alles N, Soysa N, 青木和広, 大谷啓一. Nanogel cross-linking hydrogel as a drug delivery system for the peptide type of drugs. 第50回歯科基礎医学会学術大会・総会 2008.09.23 東京

Okamoto K, Asagiri M, Hirai T, Kunigami T, Gober HJ, Nishikawa K, Aoki K, Ohya K, Kato S, Saftig P, Takayanagi H. Osteoclast-Independent Function of Cathepsin K : Regulation of Toll-like Receptor 9 Signaling in Autoimmunity. 30th ASBMR Annual Meeting 2008.09.12 Montreal

Tomomatsu N, Aoki K, Hussain MA, Alles N, Shimokawa H, Amagasa T, Ohya K. LPS-induced Inhibition of Osteogenesis is TNF-a Dependent. 30th ASBMR Annual Meeting 2008.09.12 Montreal

Alles N, Soysa N, Mian MD, Tomomatsu N, Morimoto N, Hasegawa U, Sawada S, Tada Y, Akiyoshi K, Ohya K, Aoki K. Nanogel Cross-linking Hydrogel as a Drug Delivery System for Tumor Necrosis Factor-alpha Antagonist. 30th ASBMR Annual Meeting 2008.09.12 Montreal

友松伸允，青木和広，Mian MD，下川仁彌太，天笠光雄，大谷啓一. LPS投与による抜歯後骨新生の抑制はTNF-a 依存的である. 第28回日本骨形態計測学会 2008.07.25 東京

Sriarj W, Aoki K, Ohya K, Takagi Y, Shimokawa H. Effects of Dentin Organic Matrices on Osteoclastogenesis. 86th General Session & Exhibition of the IADR 2008.07.02 Toronto

Soysa N, Alles N, Aoki K, Shimokawa H, Jimi E, Ohya K. Defective Alternative Pathway of NF-kB Causes Mild Osteopetrosis in Mice. 86th General Session & Exhibition of the IADR 2008.07.02 Toronto

Soysa N, Alles N, Mian MD, Yasuda H, Jimi E, Shimokawa H, Aoki K, Ohya K. NIK MUTATION IN ALY/ALY MICE CAUSES OSTEOPETROSIS AND REDUCE RANKL INDUCED OSTEOCLASTOGENESIS. 2nd International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems 2008.06.08 Rhodes(Greece)

Soysa N, Alles N, Aoki K, Shimokawa H, Jimi E, Ohya K. Non-canonical NF-kB pathway regulates osteoclast formation and function. 第81回日本薬理学会年会 2008.03.17 横浜

Nakalekha C, Yokoyama C, Aoki K, Ohya K, Miura H, Morita I. Alteres Bone Metabolism in Prostacyclin Synthase Deficient Female Mice. ASCB 2007 47th Annual Meeting 2007.12.01 Washington DC

Mian H, Aoki K, Alles N, Saito H, Ohya K. LPS-induced Bone Resorption is Increased in TNFR2 KO Mice in-vivo. The 55th Annual Meeting of Japanese Association for Dental Research 2007.11.17 横浜

Soysa N, Alles N, Aoki K, Shimokawa H, Jimi E, Ohya K. Defective NIK Causes Impaired Osteoclastogenesis and Mild Osteopetrosis in Mice. The 55th Annual Meeting of Japanese Association for Dental Research 2007.11.17 横浜

Mian H, Aoki K, Alles N, Saito H, Ohya K. TNFR1 and 2 Differentially Regulates Inflammatory Bone Resorption Induced by LPS in Vivo. ASBMR 29th Annual Meeting 2007.09 Honolulu

Suematsu A, Sato K, Nakashima T, Takemoto-Kimura S, Aoki K, Ohya K, Yamaguchi A, Chatila T.A, Bito H, Takayanagi H. The CaMK-CREB Pathway Regulates Osteoclast Differentiation and Function. ASBMR 29th Annual Meeting 2007.09 Honolulu

Mikuni-Takagaki Y, Miyagawa K, Kozai Y, Ito Y, Naruse K, Nagai Y, Yamato H, Kashima I, Ohya K, Aoki K. Quality and Strength of Cortical Bone Ovariectomized and Sham-operated Rats Are Lowered by Limiting Physical Activity. ASBMR 29th Annual Meeting 2007.09 Honolulu

Sriarj W, Varghese B.I, Aoki K, Ohya K, Takagi Y, Shimokawa H. Dentine Organic Matrix Down-Regulate Osteoclastic Activity in Root Resorption. ASBMR 29th Annual Meeting 2007.09 Honolulu

Alles N, Mian H, Soysa N, Saito H, Aoki K, Akiyoshi K, Ohya K. Use of Nanogels as a Drug Delivery System for Tumor Necrosis Factor-α Antagonist in Murine Bone Resorption Model. ASBMR 29th Annual Meeting 2007.09 Honolulu

Mian H，青木和広，Alles N，Soysa N，永野健一、大谷啓一. The protecting role of TNFR2 on bone resorption. The 49th Annual Meeting of Japanese Association for Oral Biology 2007.08 札幌

Soysa N，Alles N, 青木和広，自見英治郎，大谷啓一. Canonical NF-kB pathway mediates osteoclast bone resorption activity. 第25回日本骨代謝学会学術集会25th Annual Meeting of the Japanese Society for Bone and Mineral Research 2007.07 大阪

Alles N, Soysa N, Mian H, 青木和広、大谷啓一. Application of CHP Nanogel as a drug delivery system for tumor necrosis factor-α peptide antagonist in murine bone resorption model. 第27回日本骨形態計測学会 2007.05 長崎

Alles N, Mian H, Aoki K, Ohya K. CHP Nanogel and W9 peptide complex ameliorates bone resorption in the Low Ca murine model. 第80回日本薬理学会年会 2007.03 名古屋

Saito H, Aoki K, Soysa N, Baron R, Ohya K. The complete inhibition of marginal bone loss by structure-base desingned anti-TNFαpeptide in murine collagen-induced arthritis. Comparison to anti-TNFα antibody. 2006IOF+ANZBMS Combined Meeting 2006.10 Port Douglas

Aoki K, Saito H, Itzstein C, Ishiguro M, Mian A. H, Takahashi M, Yamaguchi A, Horne W. C, Ohya K, Baron R. Structure-base designed anti-TNFα peptide inhibits RANKL-induced signaling and both marginal and local bone loss induced in murine collagen-induced arthritis. 28th Annual Meeting of the American Society for Bone and Mineral Research 2006.09 Philadelphia

Gil-Henn H, Destaing O, Bruzzaniti A, Neff L, Sims N, Aoki K, Alles N, Sanjay A, Baron R, Schlessinger J. Pyk2-/- mice are osteopetrotic due to defective regulation of microtubeles and actin in osteoclasts. 28th Annual Meeting of the American Society for Bone and Mineral Research 2006.09 Philadelphia

Alles C. N. R, Morimoto N, Hasegawa U, Mian A, Soysa N. S, Saito H, Aoki K, Baron R, Akiyoshi K, Ohya K. Subcutaneous injection of W9 peptide and CHP nanogel complex inhibits the decrease of BMD Induced by a low Ca feeding in mice. 28th Annual Meeting of the American Society for Bone and Mineral Research 2006.09 Philadelphia

MD Anower Hussain Mian, 青木和広, 齋藤広章, 大谷啓一. The roles of TNF receptors in the LPS-induced bone resorption model. 第26回日本骨形態計測学会 2006.07 新潟

Soysa N, Alles C, Saito H, Aoki K, Jimi E, Ohya K. Inhibition of Ikkβ-NEMO binding blocks osteoclast activity and acting-ring formation. 84th General Session & Exhibition of IADR 2006.06 Brisbane

Mian A. H, Aoki K, Saito H, Ohya K.. TNFR-1 is critical for LPS-induced bone resorptoin in mice. 84th General Session & Exhibition of IADR 2006.06 Brisbane

Kudoh A, Kawamoto T, Nagahama K, Inokuchi T, Aoki A, Aoki K, Shibayama M, Baba Y, Suzuki S, Ohya K, Mano Y, Ohyama K. Bloodflow and bone density after distraction osteogenesis with HBO treatment. 84th General Session & Exhibition of IADR 2006.06 Brisbane

Sriarj W, Varghese B. J, Aoki K, Ohya K, Takagi Y, Shimokawa H.. Effects of dentin organic matrix on osteoclasts. 84th General Session & Exhibition of IADR 2006.06 Brisbane

Anower H, Saito H, Aoki K, Ohya K. TNF receptor Type1 has a pivotal role for local bone resorption induced by LPS in vivo. The 79th Annual Meeting of The Japanese Pharmacological Society 2006.03 横浜

Soysa Niroshani, 青木和広, 齋藤広章, 自見英治郎, 大谷啓一. Volume measurements of osteoclastic resorption lacunae by Super Depth Surface Profile Measurement Laser Microscope. 第47回歯科基礎医学会 2005.09 仙台

MD Anower Hussain Mian, 齋藤広章, 青木和広, 大谷啓一. PD-1分子の欠損はT細胞の破骨細胞抑制能力を引き上げる. 第78回日本薬理学会年会 2005.03 横浜

B.J. Varghese, H. Shimokawa, K. Aoki, K. Ohya, Y. Takagi. Osteoclastic Activity Differs When Cultured on Deciduous and Permanent Dentine. 第52回国際歯科研究学会日本部会(JADR)総会・学術大会 2004.11 東京

K. Aoki, C. Itzstein, H. Saito, M. Takahashi, M. Ishiguro, R. Murali, R. Baron, K. Ohya. A Peptide Mimicking a TNF Receptor Loop Blocks RANKL-induced Signaling. 第52回国際歯科研究学会日本部会(JADR)総会・学術大会 2004.11 東京

C. Itzstein, K. Aoki, H. Saio, R. Blanpue, P. Deprez, M. Ishiguro, W.C. Horne, R. Baron. A peptide antagonist mimicking a TNF contact site of the TNF-α receptor inhibits RANKL-induced signaling. 26th Annual Meeting of the American Society for Bone and Mineral Research 2004.10 Washington, USA

B.J. Varghese, K. Aoki, H. Shimokawa, K. Ohya, Y. Takagi. Differences in osteoclast-induced resorption of permanent and deciduous teeth. 82nd General Session & Exhibition of IADR 2004.03 Honolulu

Y. Suzuki, K. Aoki, K. Ohya, I. Ishikawa. TNF-α antagonist inhibits bone resorption induced by Porphyromonas gingivalis in mice. 51st Annual Meeting of the JADR 2003.12 Osaka

E. Jimi, K. Aoki, H. Saito, M. May, K. Ohya, S. Ghosh. Nemo (nf-kb essential modulator) binding domain (nbd) peptide prevents osteoclast differentiation in vitro and in vivo. 1st Joint Meeting of the International Bone and Mineral Society (IBMS) and the Japanese Society for Bone and Mineral Research (JSBMR) 2003.06 Osaka

T. Damrongrungruang, S. Kuroda, K. Hisatomo, K. Aoki, K. Ohya, S. Kasugai. A simple murine model for immobilization osteopenia. 1st General Session & Exhibition of the IADR 2003.06 Sweden

Y. Asawa, K. Aoki, K. Ohya, H. Ohshima, Y. Takano. Occurrence of electron dense segments in osteoidal collagen fibrils immediately adjacent to the mineralization front of bone in rats. 1st Joint Meeting of the International Bone and Mineral Society (IBMS) and the Japanese Society for Bone and Mineral Research (JSBMR) 2003.06 Osaka

H. Saito, K. Aoki, R. Murali, M. I. Greene, W. C. Horne, R. Baron, K. Ohya. A TNF-alpha antagonistic peptide inhibits bone loss induced by estrogen deficiency. 1st Joint Meeting of the International Bone and Mineral Society (IBMS) and the Japanese Society for Bone and Mineral Research (JSBMR) 2003.06 Osaka

K. Nonaka, K. Aoki, S. Hasegawa, S. Fukuda, K. Ohya. Sex difference in affection of geometric and material properties on the structural property in tibial diaphysis of cynomolgus monkeys. 1st Joint Meeting of the International Bone and Mineral Society (IBMS) and the Japanese Society for Bone and Mineral Research (JSBMR) 2003.06 Osaka

K. Nagahama, K. Aoki, K. Nonaka, K. Ohyama, K. Ohya. PD-1 deficient mice showed the mild osteopetrotic phenotype but decreased the bone volume by estrogen deficiency. 1st Joint Meeting of the International Bone and Mineral Society (IBMS) and the Japanese Society for Bone and Mineral Research (JSBMR) 2003.06 Osaka

I. Nakamura, D. G. Little, N. Haga, K. Aoki, R. Shiro, K. Ohya, S. Tanaka, K. Nakamura, C. Cowell, P. Williams. Enhanced osteoclastogenesis in congenital pseudarthrosis of the tibia and its treatment with bisphosphonate. 1st Joint Meeting of the International Bone and Mineral Society (IBMS) and the Japanese Society for Bone and Mineral Research (JSBMR) 2003.03 Osaka

Y. Suzuki, K. Aoki, I. Ishikawa, K. Ohya. A TNF-α Peptide-antagonist W9 Inhibits the Soluble RANKL-induced Osteoclastogenesis Stronger Than that Induced by Membrane-bound RANKL. 24th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR) 2002.09 San Antonio, Texas,USA

Y. Mikuni-Takagaki, K. Aoki, M. Takahashi, K. Ohya, M. Itoman. Daily Activity Triples the Efficacy of PTH on Cortical Bone Formation in Adult Female Rat. 24th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR) 2002.09 San Antonio, Texas

K. Nagahama, K. Aoki, K. Nonaka, K. Ohyama, K. Ohya. Bone Histomorphometric Analysis of PD-1 Deficient Mice – The Regulation of Tcell Activation and Bone Metabolism. 24th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR) 2002.09 San Antonio, Texas

T. Kojima, K. Aoki, K. Nonaka, R. Murali, M. I. Greene, T. Amagasa, K. Ohya, W. C. Horne, R. Baron. A TNF-α-Related Peptide Inhibits Both Bone Resorption and Inflammation in Collagen-Induced Arthritis. 24th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR) 2002.09 San Antonio, Texas

T. Juji, K. Aoki, D. Horie, K. Ohya, M. Herz, A. Gautam, S. Mouritsen, H. Oda, K. Nakamura, S. Tanaka. A Novel Therapeutic Vaccine Pathological Bone Destruction in Models of Osteoporosis and RA. 23rd Annual Meeting of the American Society for Bone and Mineral Research (ASBMR) 2001.10 Phoenix, Arizona

K.Aoki, Y.Suzuki, T.Shibata, R.Murali, W.C.Horne, M.J.Greene, K.Ohya, R.Baron. A TNF-α-Related Peptide Inhibits Bone Resorption in Vivo and Osteoclastogenesis in Vitro by Interfering with RANK/RANKL Interaction. 23rd Annual Meeting of the American Society for Bone and Mineral Research (ASBMR) 2001.10 Phoenix, Arizona

Soysa N，Alles N, Aoki K, Jimi E, Ohya K. Canonical NF-kB Pathway Mediates Osteoclast Bone Resorption Activity. ASBMR 29th Annual Meeting 2001.09 Honolulu

T. Damrongruang, S. Kuroda, D. Sato, K. Aoki, H. Kondo, K. Miyamoto, K.Ohya, S. Kasugai. Selective Drug Delivery System to Bone; (Gla)3-Conjugation. IADR 79th General Session & Exhibition 2001.06 Chiba

E. Takahashi, M. Mukohyama, K. Aoki, W. R. Duarte, S. Enomoto, K. Ohya, S. Kasugai. Extracelluar High Calcium Environment Affects Osteoclastogenesis in vitro. IADR 79th General Session & Exhibition 2001.06 Chiba

D. Horie, K. Aoki, K. Ohya. Change of Rat Bone Marrow Cell Population after Bisphosphonate Injection. IADR 79th General Session & Exhibition 2001.06 Chiba

山添知弘, 青木和広, 下川仁弥太, 高木裕三, 大谷啓一. ラット歯髄の頭部皮下移植実験における骨基質タンパクのmRNA発現について. 第42回歯科基礎医学会学術大会ならびに総会 2000.09 大阪

Damrongrungruang T, Kuroda S, Aoki K, Shibata T, Waki Y, Miyamoto K, Ohya K, Kasugai S. Simple experimental model for immobilized osteopenia in mice. 22nd Annual Meeting of the American Society for Bone and Mineral Research 2000.09 Toronto

Horie D, Aoki K, Ohya K. Effects of Clodronate on Osteoblast-like Cells. 22nd Annual Meeting of the American Society for Bone and Mineral Research 2000.09 Toronto

Sims NA, Aoki K, Bogdanovi A, Maragh M, Okigaki M, Logan S, Neff L, Didomenico E, Sanjay A, Schlessinger J, Baron R. Impaired osteoclast function in Pyk2 knockout mice and cumulative effects in Pyk2/Src double knockout. 21st Annual Meeting of the American Society for Bone and Mineral Research 1999.10.04 St. Louis, USA

Baron R, Amling M, Aoki K, Sims N. Lessons from natural mutants and transgenic mice: Is there cross-regulation between bone mass, bone formation and bone resorption?. 8th Congress of the International Society of Bone Morphometry 1999.10 Scottsdale, USA

Rungvechvuttivittaya S, Okiji T, Aoki K, Ohya K, Suda H. Responses of Pupal Macrophage-associated Antigen-expressing Cells to Tooth Replantation. 12th Annual Scientific Meeting of International Association for Dental Research 1997.09 Thailand

Seto H, Aoki K, Ohya K. Histomorphometrical study of bone resorption induced by the low calcium diet in rats during short terme xperiment. 第70 回日本薬理学会年会 1997.03 千葉

Aoki K, Seto H, Murakami H, Abe H, Barbier A, Ohya K. Effects of tiludronate on bone loss in the cancellous and cortical regions of tibia in rats fed with a low calcium diet. World Congress on Osteoporosis 1996.05 Amsterdam, Holland

青木和広, 瀬戸浩行, 大谷啓一. Different responses between cancellous and cortical bone to the bone resorption inhibitor (tiludronate) in rats. 第69 回日本薬理学会年会 1996.03 長崎