Personnel Information

写真a

Kazuhiro AOKI


Job title

Professor

Birth date

1961

Laboratory Address

No. 217 2nd Fl. Build No.2, 1-5-45, Yushima, Bunkyo-ku, Tokyo

Laboratory Phone number

+81358034641

Laboratory Fax number

+81-3-5803-4641

Mail Address

kazu.hpha@tmd.ac.jp

Homepage URL

http://www.tmd.ac.jp/english/ohe/BOHS_551299de5b5da/index.html

Research Areas, Keywords

Development of bone anabolic agents, non-invasive method of bone augmentation, Development of surface coating materials for the prevention of plaque growth,Research related to the connection between oral bacteria and systemic diseases

Profile

http://www.tmd.ac.jp/english/artis-cms/cms-files/Press_9.pdf

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Dentistry, Faculty of Dentistry, 1988, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Graduate School, Division of Dental Research, Dental Pharmacology, Doctor's Course, 1992, Completed

Degree 【 display / non-display

  • Ph.D, Tokyo Medical and Dental University

Campus Career 【 display / non-display

  • 1995.04
    -
    2009.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Matrix, Pharmacology, Assistant Professor
  • 2009.04
    -
    2017.01
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Matrix, Pharmacology, Associate Professor
  • 2017.02
    -
    2021.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Science and Technology, Basic Oral Health Engineering, Professor
  • 2021.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Science and Technology, Basic Oral Health Engineering, Professor

External Career 【 display / non-display

  • 1992.10
    -
    1995.03
    , Dentist
  • 1997.10
    -
    1999.09
    Yale University Faculty of Medicine, Department of Cell Biology, Postdoctoral fellow (Prof. Roland Baron's Lab)
  • 2010.08
    -
    2012.07
    Ministry of Education, , Program officer

Academic Society Affiliations 【 display / non-display

  • American Society of Bone and Mineral Research

  • International Association of Dental Research

  • Japanese Pharmacological Society

Research Areas 【 display / non-display

  • Functional basic dentistry

Qualification Acquired 【 display / non-display

  • Dentist

 

Published Papers & Misc 【 display / non-display

  • Rashed Fatma, Kamijyo Shingo, Shimizu Yuri, Hirohashi Yuna, Khan Masud, Sugamori Yasutaka, Murali Ramachandran, Aoki Kazuhiro. The Effects of Receptor Activator of NF-kappa B Ligand-Binding Peptides on Bone Resorption and Bone Formation FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021.07; 9 648084. ( PubMed, DOI )

  • Okawara H, Arai Y, Matsuno H, Marcián P, Borák L, Aoki K, Wakabayashi N. Effect of load-induced local mechanical strain on peri-implant bone cell activity related to bone resorption and formation in mice: An analysis of histology and strain distributions. Journal of the mechanical behavior of biomedical materials. 2021.04; 116 104370. ( PubMed, DOI )

  • Keo P, Matsumoto Y, Shimizu Y, Nagahiro S, Ikeda M, Aoki K, Ono T. A pilot study to investigate the histomorphometric changes of murine maxillary bone around the site of mini-screw insertion in regenerated bone induced by anabolic reagents. European journal of orthodontics. 2020.03; ( PubMed, DOI )

  • Takakura N, Matsuda M, Khan M, Hiura F, Aoki K, Hirohashi Y, Mori K, Yasuda H, Hirata M, Kitamura C, Jimi E. A novel inhibitor of NF-κB-inducing kinase prevents bone loss by inhibiting osteoclastic bone resorption in ovariectomized mice. Bone. 2020.03; 135 115316. ( PubMed, DOI )

  • Shigeki Nagahiro, Tomoki Uehara, Mariko Yamamoto Kawai, Preksa Keo, Hiroki Ochi, Shingo Sato, Shinji Kuroda, Takashi Ono, Michiyo Miyashin, Kazuhiro Aoki. RANKL-binding peptide promotes ectopic bone formation induced by BMP-2 gene transfer in murine gastrocnemius muscle Dental, Oral and Maxillofacial Research. 2020.01; 6 (1): ( DOI )

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Conference Activities & Talks 【 display / non-display

  • Kazuhiro Aoki. The peptide drug delivery for bone regeneration. Cutting Edge of Bone and Mineral Research in 2019 2019.12.05 Kyusyu University, Fukuoka, Japan

  • Kazuhiro Aoki. The effects of RANKL-binding peptides on osteoblast differentiation. The 42nd Annual Meeting of the Molecular Biology Society of Japan 2019.12.04 Kitakyusyu, Fukuoka, Japan

  • Yosuke Sasaki, Masud Khan, Kazuhiro Aoki. Development of a suitable scaffold for bone formation using the BMP-2 and osteogenic peptide OP3-4 combination therapy. The 2nd Meeting of International Oral Health Engineering Consortium 2019.11.18 Taipei, Taiwan

  • Yuna Hirohashi, Yuri Shimizu, Masud Khan, Yukihiko Tamura, Kazuhiro Aoki. A new RANKL-binding peptide for the development of the bone anabolic reagent. The 2nd Meeting of International Oral Health Engineering Consortium 2019.11.18 Taipei, Taiwan

  • Nakamura S, Matin K, Aoki K. Histological observations of organs after intravenous injection of Streptococcus mutans. the 41st Annual meeting of Nippon Academy of Dental Technology 2019.11.02 Kanazawa, Ishikawa, Japan

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Awards & Honors 【 display / non-display

  • The 2nd and 3rd prizes of the student competition at the 2nd Meeting of International Oral Health Engineering Consortium (Yosuke Sasaki, Yuna hirohashi),The 2nd International Oral Health Engineering Consortium (Taipei),2019.11

  • The 2nd prize of the student competition at the 1st Meeting of International Oral Health Engineering Consortium (Ayaka Urakawa) ,2018.09

  • New Investigator Award(Uehara T), 13th Congress of the Internatitonal Society of Bone Morphometry,2015.04

Others 【 display / non-display

  • The Wnt agonist R-spondin 3: an unexpected negative regulator of bone formation,2017.11

    Special lecture for PhD course student
    Dr. Kenichi Nagano Department of Oral Medicine, Infection and Innunity, Harvard School of Dental Medicine

 

Social Contribution 【 display / non-display

  • Science Diaglog (Dr. Masud Khan and Prof Kazuhiro Aoki),JSPS,Public school of Sagamihara juniro high school in Kanagawa prefecture,2018.01.20