Personnel Information


TAKANO Yoshiro

Job title

Professor(Moving Out or Retirement)

Birth date


Mail Address

The inquiry by e-mail is 《here

Homepage URL

Research Areas, Keywords

biological mineralization, amelogenesis, tooth regeneration

Graduating School 【 display / non-display

  • Niigata University, Faculty of Dentistry, 1975, Graduated

Graduate School 【 display / non-display

  • Niigata University, Graduate School, Division of Dental Research, Doctor's Course, 1979, Completed

Degree 【 display / non-display

  • Ph.D., Niigata University

Campus Career 【 display / non-display

  • 1996.01
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Matrix, Biostructural Science, Professor
  • 2021.12
    Tokyo Medical and Dental University, Professor

External Career 【 display / non-display

  • 1979.04
    Niigata University School of Dentistry, Oral Anatomy, Assistant Professor
  • 1980.03
    University of North Carolina at Chapel Hill, Dental Research Center, Research Associate
  • 1984.09
    Osaka University, School of Dentistry, Associate Professor
  • 1988.09
    Hokkaido University, School of Dentistry, Associate Professor
  • 1991.05
    Niigata University , School of Dentistry, Professor
  • 1996.01
    Tokyo Medical and Dental University, School of Dentistry, Professor
  • 2000.04
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Professor
  • 2008.08
    Aarhus University (Denmark), School of Medicine, Adjunct Professor
  • 2012.03
    Kyung-Hee University (South Korea), School of Dentistry, Adjunct Professor
  • 2001- present Professor (Biostructural Science), Graduate School of Tokyo Medical and Dental University,
  • 1996-2001 Professor (Oral Anatomy), Tokyo Medical and Dental University Faculty of Dentistry,
  • 1991-1995 Professor (Oral Anatomy), Niigata University School of Dentistry, Associate Professor (Oral Anatomy), Hokkaido University School of Dentistry,
  • 1984-1988 Associate Professor (Oral Anatomy), Osaka University School of Dentistry,
  • 1980-1982 Visiting Scientist, Dental Research Center, University of North Carolina at Chapel Hill,
  • 1979-1984 Research Associate (Oral Anatomy), Niigata University School of Dentistry,
  • 1978 Visiting Scientist, Dental Research Center, University of North Carolina at Chapel Hill,

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Academic Society Affiliations 【 display / non-display

  • JADR

  • International Association for Dental Researcg

Academic Activity 【 display / non-display

  • 2001.04
    Executive Committee Member

Research Areas 【 display / non-display

  • Oral biological science

Qualification Acquired 【 display / non-display

  • Dentist


Published Papers & Misc 【 display / non-display

  1. J Guo, D M Lyaruu, Y Takano, C W Gibson, P K DenBesten, A L J J Bronckers. Amelogenins as Potential Buffers during Secretory-stage Amelogenesis. J. Dent. Res.. 2014.12; ( PubMed, DOI )

  2. Kazuhiro Takeyama, Masahiro Chatani, Yoshiro Takano, Akira Kudo. In-vivo imaging of the fracture healing in medaka revealed two types of osteoclasts before and after the callus formation by osteoblasts. Dev. Biol.. 2014.10; 394 (2): 292-304. ( PubMed, DOI )

  3. Dawud Abduweli, Otto Baba, Makoto J Tabata, Kazunori Higuchi, Hiroshi Mitani, Yoshiro Takano. Tooth replacement and putative odontogenic stem cell niches in pharyngeal dentition of medaka (Oryzias latipes). Microscopy (Oxf). 2014.04; 63 (2): 141-153. ( PubMed, DOI )

  4. Helle H Damkier, Kaj Josephsen, Yoshiro Takano, Dirk Zahn, Ole Fejerskov, Sebastian Frische. Fluctuations in surface pH of maturing rat incisor enamel are a result of cycles of H(+)-secretion by ameloblasts and variations in enamel buffer characteristics. Bone. 2014.03; 60 227-234. ( PubMed, DOI )

  5. Chunlin Chen, Zhongchang Wang, Mitsuhiro Saito, Tetsuya Tohei, Yoshiro Takano, Yuichi Ikuhara. Fluorine in shark teeth: its direct atomic-resolution imaging and strengthening function. Angew. Chem. Int. Ed. Engl.. 2014.02; 53 (6): 1543-1547. ( PubMed, DOI )

  6. Josephsen K, Takano Y, Frische S, Praetorius J, Nielsen S, Aoba T, Fejerskov O. Ion transporters in secretory and cyclically modulating ameloblasts: a new hypothesis for cellular control of preeruptive enamel maturation. Am J Physiol, Cell Physiol. 2010.12; 299 (6): C1299-307. ( PubMed, DOI )

  7. Ahmad M, Iseki H, Abduweli D, Baba O, Tabata MJ, Takano Y. Ultrastructural and histochemical evaluation of appositional mineralization of circumpulpal dentin at the crown- and root-analog portions of rat incisors. J Electron Microsc (Tokyo). 2010.10; ( PubMed, DOI )

  8. Ohisa S, Inohaya K, Takano Y, Kudo A. sec24d encoding a component of COPII is essential for vertebra formation, revealed by the analysis of the medaka mutant, vbi. Dev Biol. 2010.06; 342 (1): 85-95. ( PubMed, DOI )

  9. Inohaya K, Takano Y, Kudo A. Production of Wnt4b by floor plate cells is essential for the segmental patterning of the vertebral column in medaka. Development. 2010.06; 137 (11): 1807-1813. ( PubMed, DOI )

  10. Nakayama H, Takakuda K, Matsumoto HN, Miyata A, Baba O, Tabata MJ, Ushiki T, Oda T, McKee MD, Takano Y. Effects of altered bone remodeling and retention of cement lines on bone quality in osteopetrotic aged c-Src-deficient mice. Calcif Tissue Int. 2010.02; 86 (2): 172-183. ( PubMed, DOI )

  11. Notani T, Tabata MJ, Iseki H, Baba O, Takano Y. Introduction of a three-dimensional and layered (TDL) culture, a novel primary co-culture method for ameloblasts and pulp-derived cells. Arch Histol Cytol. 2009; 72 (3): 187-198. ( PubMed )

  12. Li Y, Nakayama H, Notani T, Ahmad M, Tabata MJ, Takano Y. Phosphatase actions at the site of appositional mineralization in bisphosphonate-affected bones of the rat. J Med Dent Sci. 2008.09; 55 (3-4): 255-265. ( PubMed )

  13. Higuchi K, Santiwong P, Tamaki H, Terashima T, Nakayama H, Notani T, Iseki H, Baba O, Takano Y. Development and terminal differentiation of pulp and periodontal nerve elements in subcutaneous transplants of molar tooth germs and incisors of the rat. Eur J Oral Sci. 2008.08; 116 (4): 324-333. ( PubMed, DOI )

  14. Shibata S, Baba O, Oda T, Yokohama-Tamaki T, Qin C, Butler WT, Sakakura Y, Takano Y. An immunohistochemical and ultrastructural study of the pericellular matrix of uneroded hypertrophic chondrocytes in the mandibular condyle of aged c-src-deficient mice. Arch Oral Biol. 2008.03; 53 (3): 220-230. ( PubMed, DOI )

  15. Inohaya K, Takano Y, Kudo A. The teleost intervertebral region acts as a growth center of the centrum: in vivo visualization of osteoblasts and their progenitors in transgenic fish. Dev Dyn. 2007.11; 236 (11): 3031-3046. ( PubMed, DOI )

  16. Miyata A, Baba O, Oda T, Ishikawa I, Takano Y. Diverse effects of c-src deficiency on molar tooth development and eruption in mice. Arch Histol Cytol. 2007.04; 70 (1): 63-78. ( PubMed )

  17. Kuwahara M, Inoshita S, Nakano Y, Terada Y, Takano Y, Sasaki S. Expression of bone type 1 PTH receptor in rats with chronic renal failure. Clin Exp Nephrol. 2007.03; 11 (1): 34-40. ( PubMed, DOI )

  18. Nemoto Y, Higuchi K, Baba O, Kudo A, Takano Y. Multinucleate osteoclasts in medaka as evidence of active bone remodeling. Bone. 2007.02; 40 (2): 399-408. ( PubMed, DOI )

  19. Baba O, Miyata A, Abe T, Shibata S, Nakano Y, Terashima T, Oda T, Kudo A, Takano Y. Formation of acellular cementum-like layers, with and without extrinsic fiber insertion, along inert bone surfaces of aging c-Src gene knockout mice. Eur J Oral Sci. 2006.12; 114 (6): 524-534. ( PubMed, DOI )

  20. Shibata S, Oda T, Abe T, Yamashita Y, Takano Y. Structural features of incremental line-like striations in mandibular condylar cartilage of c-src-deficient mice. Arch Oral Biol. 2006.11; 51 (11): 951-959. ( PubMed, DOI )

  21. Zhang J, Kawashima N, Suda H, Nakano Y, Takano Y, Azuma M. The existence of CD11c+ sentinel and F4/80+ interstitial dendritic cells in dental pulp and their dynamics and functional properties. Int Immunol. 2006.09; 18 (9): 1375-1384. ( PubMed, DOI )

  22. Jayawardena CK, Takano Y. Nerve-epithelium association in the periodontal ligament of guinea pig teeth. Arch Oral Biol. 2006.07; 51 (7): 587-595. ( PubMed, DOI )

  23. Takano Y, Nakano Y, Yamamoto-Shuda Y, Baba O, Terashima T. Proteolysis on maturing enamel surface, as shown by gel-coating methods. Eur J Oral Sci. 2006.05; 114 Suppl 1 52-8; discussion 93-5, 379-80. ( PubMed, DOI )

  24. Nakamura S, Terashima T, Yoshida T, Iseki S, Takano Y, Ishikawa I, Shinomura T. Identification of genes preferentially expressed in periodontal ligament: specific expression of a novel secreted protein, FDC-SP. Biochem Biophys Res Commun. 2005.12; 338 (2): 1197-1203. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Masahiro Chatani, Akiko Mantoku, Kazuhiro Takeyama, Kazuhiro Aoki, Yasutaka Sugamori, Keiichi Ohya, Satoko Uchida, Hiromi Suzuki, Toru Sakimura, Yasushi Kono, Fumiaki Tanigaki, Masaki Shirakawa, Keiji Inohaya, Dawud Abduweri, Yoshiro Takano, Akira Kudo. Rearing Medaka Fish in International Space Station (ISS) for Bone Metabolism Study. ASBMR 2014.09

  2. Masahiro Chatani, Yoshiro Takano, Takeshi Todo, Akira Kudo. Imbalance of RANKL/OPG reveals the new bone resorption system with the whole-body analysis in medaka. ASBMR 2014.09

  3. C.K. Jayawardena, V. Walpola, T. Nandasena, D. Nanayakakara, and Y. Takano. Involvement of organic anion transporters in non-endocytotic uptake of amelogenins during human tooth development. Peradeniya University International Research Session 2014.07 Peradeniya University

  4. Sebastian Frische, Helle Damkier, Kaj Josephsen, Yoshiro Takano, Dirk Zahn, Ole Fejerskov. Fluctuations in Surface pH of Maturing Rat Incisor Enamel Are a Result of Cycles of H+-secretion by Ameloblasts and Variations in Enamel Buffer Characteristics.. EB2014 2014.04 San Diego

Awards & Honors 【 display / non-display

  • IADR Distinguished Scientist Award ,IADR,2004


Campus class subject 【 display / non-display

  • Histology

  • Oral Histology and Embryology