Personnel Information

写真a

ISEKI Sachiko


Job title

Professor

Laboratory Address

Molecular Craniofacial Embryology, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, 1-5-45 Yushima, Bunkyo-ku Tokyo 113-8549

Laboratory Phone number

+81-3-5803-5579

Laboratory Fax number

+81-3-5803-0213

Research Areas, Keywords

craniofacial development, skeletal development, skeletal regeneartion
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Graduating School 【 display / non-display 】

  • Tokyo Medical and Dental University, Faculty of Dentistry, school of dentistry, 1989, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Graduate School, Division of Dental Research, Doctor's Course, 1993, Completed

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Degree 【 display / non-display 】

  • doctor of phylospphy, Tokyo Medical and Dental University

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Campus Career 【 display / non-display 】

  • 2007.01
    -
    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Maxillofacial and Neck Reconstruction， Molecular Craniofacial Embryology， Professor
  • 2018.04
    -
    2019.07
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Maxillofacial and Neck Reconstruction， Molecular Craniofacial Embryology， Professor
  • 2019.08
    -
    2022.07
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Maxillofacial and Neck Reconstruction， Molecular Craniofacial Embryology， Professor
  • 2022.08
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Maxillofacial and Neck Reconstruction， Department of Molecular Craniofacial Embryology and Oral Histology， Professor
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External Career 【 display / non-display 】

  • 1994.04
    -
    1995.11
    Tokushima University, School of Dentistry, Assistant Professor
  • 1994.12
    -
    1996.11
    University of Oxford, Dept. of Human Anatomy, visiting researcher
  • 1997.12
    -
    2000.07
    University of Oxford, Dept. of Human Anatomy and Genetics, post-doctoral research assistant
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Research Theme 【 display / non-display 】

  • Regeneration of craniofacial tissues

  • Mammalian craniofacial development

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Published Papers & Misc 【 display / non-display 】

  1. Jin, CX; Adachi, N; Yoshimoto, Y; Sasabuchi, A; Kawashima, N; Ota, MS; Iseki, S. Fibroblast growth factor signalling regulates the development of tooth root JOURNAL OF ANATOMY. 2024.01; ( PubMed, DOI )

  2. Namangkalakul Worachat, Nagai Shigenori, Jin Chengxue, Nakahama Ken-ichi, Yoshimoto Yuki, Ueha Satoshi, Akiyoshi Kazunari, Matsushima Kouji, Nakashima Tomoki, Takechi Masaki, Iseki Sachiko. Augmented effect of fibroblast growth factor 18 in bone morphogenetic protein 2-induced calvarial bone healing by activation of CCL2/CCR2 axis on M2 macrophage polarization JOURNAL OF TISSUE ENGINEERING. 2023.07; 14 ( DOI )

  3. Hoshino Yukiko, Takechi Masaki, Moazen Mehran, Steacy Miranda, Koyabu Daisuke, Furutera Toshiko, Ninomiya Youichirou, Nuri Takashi, Pauws Erwin, Iseki Sachiko. Synchondrosis fusion contributes to the progression of postnatal craniofacial dysmorphology in syndromic craniosynostosis JOURNAL OF ANATOMY. 2023.03; 242 (3): 387-401. ( DOI )

  4. Lou Yixin, Matsumoto Yoshiro, Iseki Sachiko, Ono Takashi. Difference in apical resorption activity during rat molar root formation in response to mechanical force EUROPEAN JOURNAL OF ORTHODONTICS. 2023.02; ( DOI )

  5. Yamazaki Shintaro, Hirayama Ryoko, Ikeda Yayoi, Iseki Sachiko, Yoda Tetsuya, Ikeda Masa-Aki. Hyaluronic acid hydrogels support to generate integrated bone formation through endochondral ossification in vivo using mesenchymal stem cells PLOS ONE. 2023.02; 18 (2): ( DOI )

  6. Taro Nojiri, Ingmar Werneburg, Vuong Tan Tu, Dai Fukui, Masaki Takechi, Sachiko Iseki,Toshiko Furutera, Daisuke Koyabu. Timing of organogenesis underscores the evolution of neonatal life histories and powered flight in bats PROCEEDINGS OF THE ROYAL SOCIETY B . 2023.01; 290 20221928. ( PubMed, DOI )

  7. Lu Zhao, Yoshiro Matsumoto, Sachiko Iseki, Takashi Ono. Effects of short-term orthodontic force application on the root at different developmental stages in rat maxillary molars. Am J Orthod Dentofacial Orthop. 2022.12; ( PubMed, DOI )

  8. Kano Sakurako, Higashihori Norihisa, Thiha Phyo, Takechi Masaki, Iseki Sachiko, Moriyama Keiji. The role of the histone methyltransferase SET domain bifurcated 1 during palatal development BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2022.04; 598 74-80. ( DOI )

  9. Nuri Takashi, Ota Masato, Ueda Koichi, Iseki Sachiko. Quantitative Morphologic Analysis of Cranial Vault in Twist1(+/-) Mice: Implications in Craniosynostosis PLASTIC AND RECONSTRUCTIVE SURGERY. 2022.01; 149 (1): 28E-37E. ( DOI )

  10. Takenoshita Manami, Takechi Masaki, Vu Hoang Tri, Furutera Toshiko, Akagawa Chisaki, Namangkalakul Worachat, Aoto Kazushi, Kume Tsutomu, Miyashin Michiyo, Iwamoto Tsutomu, Iseki Sachiko. Cell lineage- and expression-based inference of the roles of forkhead box transcription factor Foxc2 in craniofacial development DEVELOPMENTAL DYNAMICS. 2021.08; 250 (8): 1125-1139. ( DOI )

  11. Saadat Khandakar A. S. M., Lestari Widya, Pratama Endrawan, Ma Teng, Iseki Sachiko, Tatsumi Megumi, Ikeda Masa-Aki. Distinct and overlapping roles of ARID3A and ARID3B in regulating E2F-dependent transcription via direct binding to E2F target genes INTERNATIONAL JOURNAL OF ONCOLOGY. 2021.04; 58 (4): ( DOI )

  12. Guo Long, Iida Aritoshi, Bhavani Gandham SriLakshmi, Gowrishankar Kalpana, Wang Zheng, Xue Jing-yi, Wang Juan, Miyake Noriko, Matsumoto Naomichi, Hasegawa Takanori, Iizuka Yusuke, Matsuda Masashi, Nakashima Tomoki, Takechi Masaki, Iseki Sachiko, Yambe Shinsei, Nishimura Gen, Koseki Haruhiko, Shukunami Chisa, Girisha Katta M., Ikegawa Shiro. Deficiency of TMEM53 causes a previously unknown sclerosing bone disorder by dysregulation of BMP-SMAD signaling NATURE COMMUNICATIONS. 2021.04; 12 (1): ( DOI )

  13. Vu Tri H., Takechi Masaki, Shimizu Miki, Kitazawa Taro, Higashiyama Hiroki, Iwase Akiyasu, Kurihara Hiroki, Iseki Sachiko. Dlx5-augmentation in neural crest cells reveals early development and differentiation potential of mouse apical head mesenchyme SCIENTIFIC REPORTS. 2021.01; 11 (1): ( DOI )

  14. Rajendan Arun Kumar, Arisaka Yoshinori, Yui Nobuhiko, Iseki Sachiko. Polyrotaxanes as emerging biomaterials for tissue engineering applications: a brief review INFLAMMATION AND REGENERATION. 2020.11; 40 (1): 27. ( PubMed, DOI )

  15. Rajendan Arun Kumar, Arisaka Yoshinori, Yui Nobuhiko, Iseki Sachiko. 組織工学応用のための注目されつつある生体医療材料としてのpolyrotaxane　簡易レビュー(Polyrotaxanes as emerging biomaterials for tissue engineering applications: a brief review) Inflammation and Regeneration. 2020.11; 40 1 of 8-8 of 8. ( ichushi )

  16. Rajendan Arun Kumar, Arisaka Yoshinori, Yui Nobuhiko, Iseki Sachiko. Polyrotaxanes as emerging biomaterials for tissue engineering applications: a brief review(和訳中) Inflammation and Regeneration. 2020.11; 40 1 of 8-8 of 8.

  17. Sanchez J, Miyake R, Cheng A, Liu T, Iseki S, Kume T. . Conditional inactivation of Foxc1 and Foxc2 in neural crest cells leads to cardiac abnormalities Genesis. 2020.07; 58 (7): e23364. ( DOI )

  18. Date Yuki, Kondo Hisatomo, Yamashita Atsuko, Iseki Sachiko, Kasugai Shohei, Ota Masato S.. Combined in silico analysis identified a putative tooth root formation-related gene, Chd3, which regulates DNA synthesis in HERS01a cells(和訳中) Odontology. 2020.07; 108 (3): 386-395. ( ichushi )

  19. Ohki S, Oka K, Ogata K, Okuhara S, Rikitake M, Toda-Nakamura M, Tamura S, Masao Ozaki, Iseki S, Sakai T. . Transforming Growth Factor-Beta and Sonic Hedgehog Signaling in Palatal Epithelium Regulate Tenascin-C Expression in Palatal Mesenchyme During Soft Palate Development Frontiers in Physiology. 2020.06; 11 532. ( DOI )

  20. Yamada T, Takechi M, Yokoyama N, Hiraoka Y, Ishikubo H, Usami T, Furutera T, Taga Y, Hirate Y, Kanai-Azuma M, Yoda T, Ogawa-Goto K, Iseki S. . Heterozygous mutation of the splicing factor Sf3b4 affects development of the axial skeleton and forebrain in mouse. Developmental Dynamics. 2020.05; 249 (5): 622-635. ( DOI )

  21. Shigeru Okuhara, Anahid A. Birjandi, Hadeel Adel Al-Lami, Tomoko Sagai, Takanori Amano, Toshihiko Shiroishi, Guilherme M. Xavier, Karen J. Liu, Martyn T. Cobourne, Sachiko Iseki. Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature Development. 2019.11; 146 (21): ( DOI )

  22. Cobourne MT, Iseki S, Birjandi AA, Adel Al-Lami H, Thauvin-Robinet C, Xavier GM, Liu KJ.. How to make a tongue: Cellular and molecular regulation of muscle and connective tissue formation during mammalian tongue development. Semin. Cell Dev. Biol.. 2019.07; 91 45-54. ( DOI )

  23. Zhao L, Matsumoto Y, Ono T, Iseki S.. Effects of mechanical force application on the developing root apex in rat maxillary molars. Arch Oral Biol.. 2019.05; 101 64-76. ( DOI )

  24. Rajendran AK, Arisaka Y, Iseki S, Yui N. . Sulfonated Polyrotaxane Surfaces with Basic Fibroblast Growth Factor Alter the Osteogenic Potential of Human Mesenchymal Stem Cells in Short-Term Culture. ACS Biomater. Sci. Eng.. 2019.02; ( DOI )

  25. Charoenlarp P, Rajendran AK, Fujihara R, Kojima T, Nakahama K, Sasaki Y, Akiyoshi K, Takechi M, Iseki S.. The improvement of calvarial bone healing by durable nanogel-crosslinked materials. J Biomater Sci Polym Ed. 2018.10; 29 (15): 1876-1894. ( DOI )

  26. Mya, N., Furutera, T., Okuhara, S., Kume, T., Takechi, M., Iseki, S. Transcription factor Foxc1 is involved in anterior part of cranial base formation. Congenit Anom (Kyoto). 2018.09; 58 (5): 158-166. ( PubMed, DOI )

  27. Fujiwara N, Lee JW, Kumakami-Sakano M, Otsu K, Woo JT, Iseki S, Ota MS.. Harmine promotes molar root development via SMAD1/5/8 phosphorylation. Biochem. Biophys. Res. Commun.. 2018.03; 497 (3): 924-929. ( DOI )

  28. Ota MS, Kondo K, Li Y, Iseki S, Yamashita A, Gibson CW, Kondo T.. Amelogenin X impacts age-dependent increase of frequency and number in labial incisor grooves in C57BL/6. Biochem. Biophys. Res. Commun.. 2018.02; 496 (2): 324-327. ( DOI )

  29. Sivashanmugam A, Charoenlarp P, Deepthi S, Rajendran A, Nair SV, Iseki S, Jayakumar R.. Injectable Shear-Thinning CaSO4/FGF-18-Incorporated Chitin-PLGA Hydrogel Enhances Bone Regeneration in Mice Cranial Bone Defect Model. ACS Appl Mater Interfaces. ACS Applied Materials & Interfaces. 2017.12; 9 (49): 42639-42652.

  30. Furutera T., Takechi M., Kitazawa T., Takei J., Yamada T., Tri V-H., Rijli F., Kuratani S., Iseki S.. Differing contribution of the first and second pharyngeal arches to tympanic membrane formation in the mouse and chick. Development. 2017.09; 144 (18): 3315-3324. ( DOI )

  31. Charoenlarp P., Arun Kumar R., Iseki S.. Role of Fibroblast Growth Factors in bone regeneration. Inflammation and Regeneration. 2017.08; 37 10. ( DOI )

  32. Kriangkrai R., Chareonvit S., Iseki S., Limwonge V.. Pretreatment Effect of Folic Acid on 13-Cis-RA-Induced Cellular Damage of Developing Midfacial Processes in Cultured Rat Embryos. The Open Dentistry Journal . 2017.03; 11 200-221. ( DOI )

  33. Amin M.B., Miura M. Uddin M.K., Islam M.J., Yoshida N., Iseki S., Kume T. Trainor P.A., Saitsu H. Kazushi Aoto.. Foxc2CreERT2 knock-in mice mark stage-specific Foxc2-expressing cells during mouse organogenesis. Congenital Anomalies. 2017.01; 57 (1): 24-31.

  34. Otsuki Y., Ueda K., Satoh C., Maekawa R., Yoshiura K., Iseki S.. Intermediate phenotype between ADULT syndrome and EEC syndrome caused by R243Q mutation in TP63 Plastic and Reconstructive Surgery-Global Open. 2016.12; 4 (12): e1185.

  35. Masaki Takechi, Taro Kitazawa, Tatsuya Hirasawa, Tamami Hirai, Sachiko Iseki, Hiroki Kurihara, Shigeru Kuratani. Developmental mechanisms of the tympanic membrane in mammals and non-mammalian amniotes. Congenit Anom (Kyoto). 2016.01; 56 (1): 12-17. ( PubMed, DOI )

  36. Thanit Prasitsak, Mya Nandar, Shigeru Okuhara, Shizuko Ichinose, Masato S Ota, Sachiko Iseki. Foxc1 is required for early stage telencephalic vascular development. Dev. Dyn.. 2015.05; 244 (5): 703-711. ( PubMed, DOI )

  37. R Arun Kumar, A Sivashanmugam, S Deepthi, Sachiko Iseki, K P Chennazhi, Shantikumar V Nair, R Jayakumar. Injectable Chitin-Poly(ε-caprolactone)/Nanohydroxyapatite Composite Microgels Prepared by Simple Regeneration Technique for Bone Tissue Engineering. ACS Appl Mater Interfaces. 2015.05; 7 (18): 9399-9409. ( PubMed, DOI )

  38. Michiko Yoshida, Kenji Hata, Rikako Takashima, Koichiro Ono, Eriko Nakamura, Yoshifumi Takahata, Tomohiko Murakami, Sachiko Iseki, Teruko Takano-Yamamoto, Riko Nishimura, Toshiyuki Yoneda. The transcription factor Foxc1 is necessary for Ihh-Gli2-regulated endochondral ossification. Nat Commun. 2015; 6 6653. ( PubMed, DOI )

  39. Akihiko Machida, Shigeru Okuhara, Kiyoshi Harada, Sachiko Iseki. Difference in apical and basal growth of the frontal bone primordium in Foxc1ch/ch mice. Congenit Anom (Kyoto). 2014.08; 54 (3): 172-177. ( PubMed, DOI )

  40. Yoko Kameda, Takayoshi Saitoh, Noriko Nemoto, Tokio Katoh, Sachiko Iseki, Takao Fujimura. Hes1 is required for the development of pharyngeal organs and survival of neural crest-derived mesenchymal cells in pharyngeal arches. Cell Tissue Res.. 2013.07; 353 (1): 9-25. ( PubMed, DOI )

  41. Tomoko Nagayama, Shigeru Okuhara, Masato S Ota, Noriko Tachikawa, Shohei Kasugai, Sachiko Iseki. FGF18 accelerates osteoblast differentiation by upregulating Bmp2 expression. Congenit Anom (Kyoto). 2013.06; 53 (2): 83-88. ( PubMed, DOI )

  42. A Oshiro, S Iseki, M Miyauchi, T Terashima, Y Kawaguchi, Y Ikeda, T Shinomura. Lipopolysaccharide induces rapid loss of follicular dendritic cell-secreted protein in the junctional epithelium. J. Periodont. Res.. 2012.12; 47 (6): 689-694. ( PubMed, DOI )

  43. Masako Fujioka-Kobayashi, Masato S Ota, Asako Shimoda, Ken-ichi Nakahama, Kazunari Akiyoshi, Youji Miyamoto, Sachiko Iseki. Cholesteryl group- and acryloyl group-bearing pullulan nanogel to deliver BMP2 and FGF18 for bone tissue engineering. Biomaterials. 2012.10; 33 (30): 7613-7620. ( PubMed, DOI )

  44. Hiroyuki Suzuki, Naoto Suda, Momotoshi Shiga, Yukiho Kobayashi, Masataka Nakamura, Sachiko Iseki, Keiji Moriyama. Apert syndrome mutant FGFR2 and its soluble form reciprocally alter osteogenesis of primary calvarial osteoblasts. J. Cell. Physiol.. 2012.09; 227 (9): 3267-3277. ( PubMed, DOI )

  45. Yoko Kameda, Takayoshi Saitoh, Noriko Nemoto, Tokio Katoh, Sachiko Iseki. Hes1 is required for the development of the superior cervical ganglion of sympathetic trunk and the carotid body. Dev. Dyn.. 2012.08; 241 (8): 1289-1300. ( PubMed, DOI )

  46. Atsuko Taki, Mayumi Abe, Motohiro Komaki, Kikuko Oku, Sachiko Iseki, Shuki Mizutani, Ikuo Morita. Expression of angiogenesis-related factors and inflammatory cytokines in placenta and umbilical vessels in pregnancies with preeclampsia and chorioamnionitis/funisitis. Congenit Anom (Kyoto). 2012.06; 52 (2): 97-103. ( PubMed, DOI )

  47. Ryosuke Nagaoka, Shigeru Okuhara, Yutaka Sato, Teruo Amagasa, Sachiko Iseki. Effects of embryonic hypoxia on lip formation. Birth Defects Res. Part A Clin. Mol. Teratol.. 2012.04; 94 (4): 215-222. ( PubMed, DOI )

  48. Y Date, Y Yokoyama, H Kondo, S Kuroda, K Ohya, M S Ota, S Iseki, S Kasugai. Restricted expression of chromatin remodeling associated factor Chd3 during tooth root development. J. Periodont. Res.. 2012.04; 47 (2): 180-187. ( PubMed, DOI )

  49. Widya Lestari, Solachuddin J A Ichwan, Megumi Otsu, Shumpei Yamada, Sachiko Iseki, Shihoko Shimizu, Masa-Aki Ikeda. Cooperation between ARID3A and p53 in the transcriptional activation of p21WAF1 in response to DNA damage. Biochem. Biophys. Res. Commun.. 2012.01; 417 (2): 710-716. ( PubMed, DOI )

  50. Teng Ma, Shumpei Yamada, Solachuddin J A Ichwan, Sachiko Iseki, Kiyoshi Ohtani, Megumi Otsu, Masa-Aki Ikeda. Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient in p53Ser46 phosphorylation. Biochem. Biophys. Res. Commun.. 2012.01; 417 (3): 931-937. ( PubMed, DOI )

  51. Sachiko Iseki. Disintegration of the medial epithelial seam: is cell death important in palatogenesis? Dev. Growth Differ.. 2011.02; 53 (2): 259-268. ( PubMed, DOI )

  52. N Ebe, M Hara-Yokoyama, K Iwasaki, S Iseki, S Okuhara, K A Podyma-Inoue, K Terasawa, A Watanabe, T Akizuki, H Watanabe, M Yanagishita, Y Izumi. Pocket epithelium in the pathological setting for HMGB1 release. J. Dent. Res.. 2011.02; 90 (2): 235-240. ( PubMed, DOI )

  53. Okuhara S., Iseki S.. Epithelial integrity in palatal shelf elevation. Japanese Dental Science Review . 2011; 48 (1): 18-22.

  54. Noriaki Shimada, Kyoko Ohno-Matsui, Sachiko Iseki, Masato Koike, Yasuo Uchiyama, Jiying Wang, Takeshi Yoshida, Tetsuji Sato, Christoph Peters, Manabu Mochizuki, Ikuo Morita. Cathepsin L in bone marrow-derived cells is required for retinal and choroidal neovascularization. Am. J. Pathol.. 2010.05; 176 (5): 2571-2580. ( PubMed, DOI )

  55. Ayako Kimura, Hiroyuki Inose, Fumiko Yano, Koji Fujita, Toshiyuki Ikeda, Shingo Sato, Makiko Iwasaki, Tetsuya Jinno, Keisuke Ae, Seiji Fukumoto, Yasuhiro Takeuchi, Hiroshi Itoh, Takeshi Imamura, Hiroshi Kawaguchi, Ung-il Chung, James F Martin, Sachiko Iseki, Ken-ichi Shinomiya, Shu Takeda. Runx1 and Runx2 cooperate during sternal morphogenesis. Development. 2010.04; 137 (7): 1159-1167. ( PubMed, DOI )

  56. Ayako Mikura, Shigeru Okuhara, Masahiro Saito, Masato Ota, Koichi Ueda, Sachiko Iseki. Association of tenascin-W expression with mineralization in mouse calvarial development. Congenit Anom (Kyoto). 2009.06; 49 (2): 77-84. ( PubMed, DOI )

  57. Mima Shikanai, Kinji Asahina, Sachiko Iseki, Kenichi Teramoto, Tomohiro Nishida, Keiko Shimizu-Saito, Masato Ota, Kazuhiro Eto, Hirobumi Teraoka. A novel method of mouse ex utero transplantation of hepatic progenitor cells into the fetal liver. Biochem. Biophys. Res. Commun.. 2009.04; 381 (2): 276-282. ( PubMed, DOI )

  58. Masayo Harada, Hirotaka Murakami, Akihiko Okawa, Noriaki Okimoto, Shuichi Hiraoka, Taka Nakahara, Ryogo Akasaka, Yo-Ichi Shiraishi, Noriyuki Futatsugi, Yoko Mizutani-Koseki, Atsushi Kuroiwa, Mikako Shirouzu, Shigeyuki Yokoyama, Makoto Taiji, Sachiko Iseki, David M Ornitz, Haruhiko Koseki. FGF9 monomer-dimer equilibrium regulates extracellular matrix affinity and tissue diffusion. Nat. Genet.. 2009.03; 41 (3): 289-298. ( PubMed, DOI )

  59. Eiko Ozono, Hideyuki Komori, Ritsuko Iwanaga, Masa-Aki Ikeda, Sachiko Iseki, Kiyoshi Ohtani. E2F-like elements in p27(Kip1) promoter specifically sense deregulated E2F activity. Genes Cells. 2009.01; 14 (1): 89-99. ( PubMed, DOI )

  60. B McBratney-Owen, S Iseki, S D Bamforth, B R Olsen, G M Morriss-Kay. Development and tissue origins of the mammalian cranial base. Dev. Biol.. 2008.10; 322 (1): 121-132. ( PubMed, DOI )

  61. Toshiyuki Yoshida, Philaiporn Vivatbutsiri, Gillian Morriss-Kay, Yumiko Saga, Sachiko Iseki. Cell lineage in mammalian craniofacial mesenchyme. Mech. Dev.. 2008.09; 125 (9-10): 797-808. ( PubMed, DOI )

  62. Philaiporn Vivatbutsiri, Shizuko Ichinose, Marjo Hytönen, Kirsi Sainio, Kazuhiro Eto, Sachiko Iseki. Impaired meningeal development in association with apical expansion of calvarial bone osteogenesis in the Foxc1 mutant. J. Anat.. 2008.05; 212 (5): 603-611. ( PubMed, DOI )

  63. Ariko Kojima, Ken-Ichi Nakahama, Kyoko Ohno-Matsui, Noriaki Shimada, Keisuke Mori, Sachiko Iseki, Tetsuji Sato, Manabu Mochizuki, Ikuo Morita. Connexin 43 contributes to differentiation of retinal pigment epithelial cells via cyclic AMP signaling. Biochem. Biophys. Res. Commun.. 2008.02; 366 (2): 532-538. ( PubMed, DOI )

  64. Eleni Hjiantoniou, Mustafa Anayasa, Paschalis Nicolaou, Ioannis Bantounas, Masahiro Saito, Sachiko Iseki, James B Uney, Leonidas A Phylactou. Twist induces reversal of myotube formation. Differentiation. 2008.02; 76 (2): 182-192. ( PubMed, DOI )

  65. Sachiko Iseki, Masako Ishii-Suzuki, Naoko Tsunekawa, Yoko Yamada, Kazuhiro Eto, Kunihiko Obata. Experimental induction of palate shelf elevation in glutamate decarboxylase 67-deficient mice with cleft palate due to vertically oriented palatal shelf. Birth Defects Res. Part A Clin. Mol. Teratol.. 2007.10; 79 (10): 688-695. ( PubMed, DOI )

  66. Yoko Kameda, Toshiyuki Nishimaki, Osamu Chisaka, Sachiko Iseki, Henry M Sucov. Expression of the epithelial marker E-cadherin by thyroid C cells and their precursors during murine development. J. Histochem. Cytochem.. 2007.10; 55 (10): 1075-1088. ( PubMed, DOI )

  67. T Yokoi, M Saito, T Kiyono, S Iseki, K Kosaka, E Nishida, T Tsubakimoto, H Harada, K Eto, T Noguchi, T Teranaka. Establishment of immortalized dental follicle cells for generating periodontal ligament in vivo. Cell Tissue Res.. 2007.02; 327 (2): 301-311. ( PubMed, DOI )

  68. Masayuki Tanaka, Shinichi Okudaira, Yasuhiro Kishi, Ryunosuke Ohkawa, Sachiko Iseki, Masato Ota, Sumihare Noji, Yutaka Yatomi, Junken Aoki, Hiroyuki Arai. Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid. J. Biol. Chem.. 2006.09; 281 (35): 25822-25830. ( PubMed, DOI )

  69. Rungarun Kriangkrai, Suconta Chareonvit, Koichi Yahagi, Michio Fujiwara, Kazuhiro Eto, Sachiko Iseki. Study of Pax6 mutant rat revealed the association between upper incisor formation and midface formation. Dev. Dyn.. 2006.08; 235 (8): 2134-2143. ( PubMed, DOI )

  70. Rungarun Kriangkrai, Sachiko Iseki, Kazuhiro Eto, Suconta Chareonvit. Dual odontogenic origins develop at the early stage of rat maxillary incisor development. Anat. Embryol.. 2006.03; 211 (2): 101-108. ( PubMed, DOI )

  71. Sayaka Nakamura, Tatsuo Terashima, Toshiyuki Yoshida, Sachiko Iseki, Yoshiro Takano, Isao Ishikawa, Tamayuki Shinomura. Identification of genes preferentially expressed in periodontal ligament: specific expression of a novel secreted protein, FDC-SP. Biochem. Biophys. Res. Commun.. 2005.12; 338 (2): 1197-1203. ( PubMed, DOI )

  72. Toshiyuki Yoshida, Leonidas A Phylactou, James B Uney, Isao Ishikawa, Kazuhiro Eto, Sachiko Iseki. Twist is required for establishment of the mouse coronal suture. J. Anat.. 2005.05; 206 (5): 437-444. ( PubMed, DOI )

  73. Bantounas I, Glover CP, Kelly S, Iseki S, Phylactou LA, Uney JB. Assessing adenoviral hammerhead ribozyme and small hairpin RNA cassettes in neurons: inhibition of endogenous caspase-3 activity and protection from apoptotic cell death. J Neurosci Res. 2005.03; 79 (5): 661-669. ( PubMed, DOI )

  74. Asami-Miyagishi R, Iseki S, Usui M, Uchida K, Kubo H, Morita I. Expression and function of PPARgamma in rat placental development. Biochem Biophys Res Commun. 2004.03; 315 (2): 497-501. ( PubMed, DOI )

  75. Fujino M, Osumi N, Ninomiya Y, Iseki S, Shibasaki Y, Eto K. Disappearance of epidermal growth factor receptor is essential in the fusion of the nasal epithelium. Anat Sci Int. 2003.03; 78 (1): 25-35. ( PubMed, DOI )

  76. Hjiantoniou E, Iseki S, Uney JB, Phylactou LA. DNazyme-mediated cleavage of Twist transcripts and increase in cellular apoptosis. Biochem Biophys Res Commun. 2003.01; 300 (1): 178-181. ( PubMed )

  77. Kubota K, Iseki S, Kuroda S, Oida S, Iimura T, Duarte WR, Ohya K, Ishikawa I, Kasugai S. Synergistic effect of fibroblast growth factor-4 in ectopic bone formation induced by bone morphogenetic protein-2. Bone. 2002.10; 31 (4): 465-471. ( PubMed )

  78. Jiang X, Iseki S, Maxson RE, Sucov HM, Morriss-Kay GM. Tissue origins and interactions in the mammalian skull vault. Dev Biol. 2002.01; 241 (1): 106-116. ( PubMed, DOI )

  79. Hall M, Gofflot F, Iseki S, Morriss-Kay GM. Effects of the curly tail genotype on neuroepithelial integrity and cell proliferation during late stages of primary neurulation. J Anat. 2001.12; 199 (Pt 6): 645-655. ( PubMed )

  80. Morriss-Kay GM, Iseki S, Johnson D. Genetic control of the cell proliferation-differentiation balance in the developing skull vault: roles of fibroblast growth factor receptor signalling pathways. Novartis Found Symp. 2001; 232 102-16; discussion 116-21. ( PubMed )

  81. Iseki S., Morriss-Kay G.M. and Eto K. . Study of Fibroblast Growth Factor Receptor Signalling during Skull Vault Development by Ex-Utero Surgery. J . Hard Tissue Biology. 2001; (10): 25-29.

  82. Johnson D, Iseki S, Wilkie AO, Morriss-Kay GM. Expression patterns of Twist and Fgfr1, -2 and -3 in the developing mouse coronal suture suggest a key role for twist in suture initiation and biogenesis. Mech Dev. 2000.03; 91 (1-2): 341-345. ( PubMed )

  83. Iseki S, Wilkie AO, Morriss-Kay GM. Fgfr1 and Fgfr2 have distinct differentiation- and proliferation-related roles in the developing mouse skull vault. Development. 1999.12; 126 (24): 5611-5620. ( PubMed )

  84. Oldridge M, Zackai EH, McDonald-McGinn DM, Iseki S, Morriss-Kay GM, Twigg SR, Johnson D, Wall SA, Jiang W, Theda C, Jabs EW, Wilkie AO. De novo alu-element insertions in FGFR2 identify a distinct pathological basis for Apert syndrome. Am J Hum Genet. 1999.02; 64 (2): 446-461. ( PubMed, DOI )

  85. Iseki S, Wilkie AO, Heath JK, Ishimaru T, Eto K, Morriss-Kay GM. Fgfr2 and osteopontin domains in the developing skull vault are mutually exclusive and can be altered by locally applied FGF2. Development. 1997.09; 124 (17): 3375-3384. ( PubMed )

  86. Osumi-Yamashita N, Kuratani S, Ninomiya Y, Aoki K, Iseki S, Chareonvit S, Doi H, Fujiwara M, Watanabe T, Eto K. Cranial anomaly of homozygous rSey rat is associated with a defect in the migration pathway of midbrain crest cells. Dev Growth Differ. 1997.02; 39 (1): 53-67. ( PubMed )

  87. Koyama E, Yamaai T, Iseki S, Ohuchi H, Nohno T, Yoshioka H, Hayashi Y, Leatherman JL, Golden EB, Noji S, Pacifici M. Polarizing activity, Sonic hedgehog, and tooth development in embryonic and postnatal mouse. Dev Dyn. 1996.05; 206 (1): 59-72. ( PubMed, DOI )

  88. Iseki S, Araga A, Ohuchi H, Nohno T, Yoshioka H, Hayashi F, Noji S. Sonic hedgehog is expressed in epithelial cells during development of whisker, hair, and tooth. Biochem Biophys Res Commun. 1996.01; 218 (3): 688-693. ( PubMed, DOI )

  89. Iseki S, Osumi-Yamashita N, Miyazono K, Franzen P, Ichijo H, Ohtani H, Hayashi Y, Eto K. Localization of transforming growth factor-beta type I and type II receptors in mouse development. Exp Cell Res. 1995.08; 219 (2): 339-347. ( PubMed, DOI )

  90. Matsuo T, Osumi-Yamashita N, Noji S, Ohuchi H, Koyama E, Myokai F, Matsuo N, Taniguchi S, Doi H, Iseki S, et al.. A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cells. Nat Genet. 1993.04; 3 (4): 299-304. ( PubMed, DOI )

  91. Iseki S. [Expression of glucocorticoid receptor gene during development of mouse embryos] Kokubyo Gakkai Zasshi. 1993.03; 60 (1): 66-80. ( PubMed )

  92. Osumi-Yamashita N., Iseki S., Noji S., Koyama E., Taniguchi S., Doi H. and Eto K. . Retinoic acid treatment induces the ectopic expression of retionoic acid receptor b and excessive cell death in the embryonic mouse face. Dev. Growth Differ. 1992; 34 (2): 199-209.

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Conference Activities & Talks 【 display / non-display 】

  1. Sachiko Iseki. FGF18 Modulates M2-like Macrophage Polarization by Inducing CCL2-CCR2 Axis in Calvarial Bone Healing. Craniofacial Morphogenesis and Tissue Regeneration, Gordon Research Conference. 2022.10.18 Ventura, CA, United States

  2. Lou Yixin, Matsumoto Yoshiro, Iseki Sachiko, Qi Jia, Ono Takashi. ラットにおけるlight orthodontic forceの応用/除去による歯根吸収/修復と関連サイトカインの観察(Observation of root resorption/repair and related cytokines by application/removal of light orthodontic force in rats). 日本矯正歯科学会大会プログラム・抄録集 2022.10.01

  3. 井関祥子. craniosynostosisの発症メカニズム. 第65回日本形成外科学会総会・学術集会 2022.04.22

  4. 武智正樹、星野裕紀子、Mehran Moazen、小薮大輔、Erwin Pauws、井関祥子. 頭蓋縫合早期癒合症モデルマウスにおける頭蓋骨成長の幾何学的形態測定解析. 第127回日本解剖学会総会・全国学術集会 2022.03.27 オンライン

  5. 井関 祥子. 形づくり(頭蓋顎顔面形態形成). 口腔病学会雑誌 2022.03.01

  6. Masaki Takechi, Yukiko Hoshino, Mehran Moazen, Daisuke Koyabu, Sachiko Iseki. Ontogenic trajectories of cranial growth in syndromic craniosynostosis mouse models. 第44回日本分子生物学会 2021.12.01

  7. Yukiko Hoshino, Masaki Takechi, Mehran Moazen, Daisuke Koyabu, Toshiko Furutera, Youichiro Ninomiya, Erwin Pauws, Takashi Nuri, Sachiko Iseki. Ontogenic trajectories of cranial growth in syndromic craniosynostosis mouse models. 2nd Advances in Craniosynostosis Basic Science to Clinical Practice 2021.08.27

  8. Takechi Masaki, Vu Hoang Tri, Shimizu Miki, Kitazawa Taro, Higashiyama Hiroki, Iwase Akiyasu, Kurihara Hiroki, Iseki Sachiko. 神経堤細胞特異的にDlx5を強制発現させたマウスにより示された初期頭頂部間葉の潜在的骨・軟骨分化能(Forced expression of Dlx5 in mouse neural crest cells reveals differentiation potential of bone and cartilage in early apical cranial mesenchyme). The Journal of Physiological Sciences 2021.08.01

  9. Worachat Namangkalakul, Shigenori Nagai, Ken-ichi Nakahama, Kazunari Akiyoshi, Masaki Takechi, Sachiko Iseki. Fibroblast Growth Factor18 Activity on Calvarial Bone Regeneration. 2021IADR/AADR/CADR General session & Exhibition 2021.07.21

  10. 形づくり(頭蓋顎顔面形態形成) . 2021.02.13

  11. Sachiko ISEKI. Classification and pathological mechanisms of Craniosynostosis based on the differentiation pattern of iPS cells. 第68回国際歯科研究学会　日本部会総会・学術大会 2020.11.07

  12. 井関祥子、柳澤昇平、Arun Kumar Rajendran、有坂慶紀、塗隆志、原田敦子、小林真司、上田晃一、武智正樹、由井伸彦. 臨床応用を目指した骨芽細胞分化のコントロール. 第29回日本形成外科学会基礎学術集会 2020.10.09 横浜

  13. 先天性顎顔面形成不全研究の現在と展望　神経堤細胞由来頭部間葉の分化について . 日本歯科基礎医学会 2020.09.11 鹿児島（オンライン）

  14. Arun Kumar Rajendran，Yoshinori Arisaka，Shohei Yanagisawa, Takashi Nuri, Atsuko Harada, Koichi Ueda, Masaki Takechi, Nobuhiko Yui, Sachiko Iseki. Regulating osteogenic differentiation by supramolecular mobility-a treatment for craniosynostosis?. Gordon Research Conference, Craniofacial Morphogenesis and Tissue Regeneration Il Ciocco 2020.02.27 Italy

  15. Sachiko ISEKI. 頭蓋縫合早期癒合症患者由来骨芽細胞および骨芽細胞由来iPS細胞の再分化過程における関連遺伝子発現パターンの検討. 第42回日本分子生物学会年会 2019.12.03 福岡国際会議場、マリンメッセ、博多

  16. Arun Kumar Rajendran, Yoshinori Arisaka, Nobuhiko Yui, Sachiko Iseki. Molecular mobile surfaces for maintaining osteogenic potential of MSCs during in vitro expansion. 第40回日本炎症・再生医学会 2019.07.16

  17. 横山紀典, 武智正樹, 井関祥子. マウス胚とニワトリ胚の骨芽細胞におけるX型コラーゲンの発現解析. 2017年度生命科学系学会合同年次大会（ConBio2017） 2017.12.06 神戸国際展示場

  18. Mya N, Takechi M, Okuhara S, Furutera T, Kume T, Iseki S. Understanding the role of Foxc1 transcription factor in the development of cranial base.. 第57回日本先天異常学会学術集会 2017.08.26 早稲田大学西早稲田キャンパス

  19. Yuki Otsuki, Koichi Ueda, Chisei Sato, Koichiro Yoshiura, Sachiko Iseki. A intermediate phenotype between ADULT syndrome and EE syndrome caused by R243Q mutation in TP63.. The 13th Japan Korea Congress of Plastic and Reconstructive Surgery 2016.05.15

  20. Sachiko Iseki. Shh functions in oropharyngeal region. Oral intractable disease project, Osaka University, International Symposium 2015 2015.12.10

  21. Endrawan Pratama, Khandakar A S M Saadat，Widya Lestari，Solachuddin J. A. Ichwan, Sachiko Iseki, Kiyoshi Ohtani，Masa-Aki Ikeda. ARID3B promotes gene expression critical for E2f-mediated cell cycle progression and p53-mediated apotosis. Biochemistry and Molecular Biology (BMB2015) 2015.12.01 Kobe

  22. Saadat Khandakar Asm, Arman Kaifee, Arslan Ahmet, Sachiko Iseki, Kiyoshi Ohtani, Masa-Aki Ikeda. Expression study of E2F-target genes in osteosarcoma (U2OS) and glioblastoma (T98G) cell lines after knocking down ARID3A and ARID3B. XIV. National Congress of Medical Biology and Genetics 2015.10.27 Fethiye, Turkey

  23. 井関祥子. Foxc1 function in craniofacial development. The 4th Tripartite Conference on Tooth and Bone: Development & Regeneration 2015.06.12 千葉　成田

  24. Masaki Takechi, Taro Kitazawa, Junko Takei, Yukiko Kurihara, Sachiko Iseki, Hiroki Kurihara, Shigeru Kuratani. Comparative developmental analysis of middle ear formation in mouse and chicken embryos. 第120回日本解剖学会全国学術集会 2015.03 神戸国際会議場・展示場

  25. Sachiko Iseki. Opposing effects of FGF18 and FGF2 on postnatal bone healing and fetal bone formation. Indo-Australian Conference on Biomaterials, Tissue Engineering, Drug Delivery System & Regenerative Medicine (BiTERM 2015) 2015.02.05

  26. Michiko Yoshida, Kenji Hata, Sachiko Iseki, Teruko Takano-Yamamoto, Toshiyuki Yoneda,　Riko Nishimura. Forkhead protein FoxC1 regulates chondrogenic genes expression by modulating Ihh/Gli2 signaling. 2013 Annual Meeting of the American Society for Bone and Mineral Research 2013.10.04

  27. 井関祥子、奥原滋、太田正人、春日井昇平. Opposing effects of FGF18 and FGF2 on osteogenesis of developing mouse fetal skull. 55回歯科基礎医学会学術大会・総会　 2013.09.20

  28. Sachiko Iseki, Tomoko Nagayama, Masako Fujioka-Kobayashi, Shigeru Okuhara, Kazunari Akiyoshi, Masato S Ota, Shohei Kasugai. Opposing effects of FGF18 and FGF2 on osteogenesis and its differential effects on Fgfr, Twist1 and Bmp2.. 2013 Tripartite Conference on Tooth and Bone 2013.08.08

  29. 井関祥子. 頭蓋冠形成　–正常と異常のメカニズム-. 第53回日本先天異常学会学術集会 2013.07.21

  30. 町田章彦、奥原滋、原田清、井関祥子. 髄膜でのFoxc1によるTwist1とBmp7の発現調節は頭蓋冠骨の頭頂側への成長を制御する. 第53回日本先天異常学会学術集会 2013.07.21

  31. Thanit Prasitsak, Masato S Ota, Sachiko Iseki. The Role of Foxc1 in Telencephalic Vascular Development.. 57th Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida 2013.06.25

  32. Thanit Prasitsak, Masato S Ota, Sachiko Iseki. The Role of Foxc1 in Telencephalic Vascular Development. 第46回日本発生生物学会 2013.05.28 松江

  33. 町田章彦、奥原滋、原田清、井関祥子. 髄膜におけるFoxc1/Twist1を介したBmp7の発現は頭蓋冠骨の頭頂側への成長を制御する. 第67回日本口腔科学会 2013.05.22

  34. 小林真左子、宮本洋二、井関祥子. BMP2の骨誘導に対するFGFファミリーの併用効果. 第67回日本口腔科学会 2013.05.22 宇都宮

  35. 小林真左子、宮本洋二、井関祥子. 新規徐放性ナノゲルを用いたFGF18によるBMP2依存的な骨修復能の改良. 第67回日本口腔科学会 2012.10.19

  36. Michiko Yoshida, Kenji Hata, Rikako Takashima, Sachiko Iseki, Teruko Takano-Yamamoto, Riko Nishimura, Toshiyuki Yoneda. The transcription factor FoxC1 regulates chondrogenesis together with Gli2 through induction of PTHrP.. 2012 Annual Meeting of the American Society for Bone and Mineral Research 2012.10.12

  37. Sachiko Iseki, Akihiko Machida, Thanit Prasitsak. Congenital hydrocephalus and blood vessel network formation.. 56th Annual Meeting of the SRSHB 2012.07.25

  38. 吉田倫子、波多賢二、高島利加子、井関祥子、山本照子、西村理行、米田俊之. 転写因子Foxc1はPTHrPの発現誘導を介して内軟骨性骨形成を制御する. 第30回骨代謝学会学術集会 2012.07.19

  39. 町田章彦、奥原滋、原田清、井関祥子. Foxc1遺伝子の頭蓋冠骨発生における機能. 第52回日本先天異常学会学術集会 2012.07.06

  40. 永山　友子、中原　貴、奥原　滋、太田　正人、立川　敬子、　春日井　昇平、井関　祥子. FGF18とFGF2はFgfr,Twist1,Bmpの発現に異なる影響を与えて、骨形成過程に相反する効果を示す. 第３３回日本炎症・再生医学会 2012.07.05

  41. Shigeru Okuhara, Tomoko Sagai, Ryosuke Nagaoka, Takanori Amano, Toshihiko Shiroishi, Sachiko Iseki. Tongue and palate development in Shh-/+MFCS4+/-　. 第45回日本発生生物学会日本細胞生物学会合同年会 2012.05.28

  42. Masato Ota, Shigeru Okuhara, Sachiko Iseki. Shh-Fgf18 regulation is disrupted in tooth root development of Ptc mes mutants. 第45回日本発生生物学会日本細胞生物学会合同年会　 2012.05.28

  43. Sachiko Iseki . Opposing effects of FGF18 and FGF2 on developing cranial bones by different influences on Fgfr, Twist1 and Bmp expression. Gordon Research Conference "Craniofacial Morphogenesis & Tissue Regeneration 2012.05.13

  44. Masako Fujioka-Kobayashi, Masato S. Ota, Asako Shimoda, Kenichi Nakahama, Kazunari Akiyoshi, Youji Miyamoto, Sachiko Iseki. FGF18 synergistically enhances BMP2-dependent bone repair.. Gordon Research Conference Fibroblast Growth Factors in Development & Disease 2012.05.13

  45. Tomoko Nagayama, Taka Nakahara, Shigeru Okuhara, Masato Ota, Noriko Tachikawa, Shohei Kasugai, Sachiko Iseki . Opposing effects of FGF18 and FGF2 on developing cranial bones by different influences on Fgfr, Twist1 and Bmp expression.. Gordon Research Conference Craniofacial Morphogenesis & Tissue Regeneration 2012.03.18

  46. 奥原　滋, 嵯峨井　知子, 長岡　亮介, 天野　孝紀、 城石　俊彦, 井関　祥子. 咽頭領域発生におけるShhの役割. 第34回日本分子生物学会年会 2011.12.13

  47. 太田正人、井関祥子. 神経堤細胞特異的Meis2ノックアウトマウスにおける表現型解析. 第53回歯科基礎医学会学術大会・総会 2011.09.18

  48. 横山紀典、市野瀬志津子、町田章彦、井関祥子. 脈絡叢形成と脳の血管網構築におけるFoxc1遺伝子の機能. 第51回日本先天異常学会 2011.07.08

  49. 小林真左子、太田正人、下田麻子、秋吉一成、宮本洋二、井関祥子. 新規徐放性ナノゲルを用いたFGF18によるBMP2依存的な骨修復能の改良. 第31回日本炎症・再生医学会 2011.06.02

  50. Sachiko Iseki, Norisuke Yokoyama, Akihiko Machida, Shigeru Okuhara. Involvement of Foxc1 in vascular network formation. 第44回日本発生生物学会 2011.05.18

  51. Okuhara S, Sagai T., Nagaoka R., Amano T., Shiroishi T., Iseki S.. Cleft palate in compound heterozygote of sonic hedgehog and MFCS4. The 16th International Society of Differntiation Conference 2010.11.15

  52. Nagaoka R., Okuhara S., Amagasa T., Iseki S.. Effects of embryonic hypoxia on maxillofacial development.. The 16th International Society of Differntiation Conference 2010.11.15

  53. Iseki S.. Stem cells in Craniofacial Mesenchyme. International Symposium on Stem Cells, Organogenesis, and Regeneration in Fayoum　&　Fayoum University Lecture Series on Stem Cells, Organogenesis and Regeneration 2010.10.27

  54. Iseki S.. Involvement of the meninges in calvarial bone development. atnKorean Association of Anatomists meeting 2010.10.13

  55. Nikolaos M., Mustafa A., Antonis, A., Iseki S.. Twist reverses muscle cell differentiation.. Molecular and Cellular basis of Regeneration and Repair, EMBO Conference Series, Sesimbra Portugal, 2010.09.26

  56. 大城暁子, 井関祥子, 寺島達夫, 池田裕一, 篠村多摩之. FDC-SPタンパク質の分泌と局在. 第52回歯科基礎医学会学術大会・総会 2010.09.21

  57. Lee JW., Ota MS., Fujiwara N., Yonezawa T., Date Y., Harada H., Iseki S., Seo HJ., Jeon WB., Cha BY.1, Nagai K., Woo JT.. 1Biological effects of cyclic diarylheptanoids on tooth root formation. The 10th Tooth Morphogenesis and Differentiation. The 10th Tooth Morphogenesis and Differentiation 2010.09.01

  58. Suzuki H., Suda N., Shiga M., Tanimoto Y., Nakamura M., Iseki S., Moriyama K.. Osteoblastic differentiation of transgenic mice overexpressing Apert syndrome-type mutant FGFR2 and its soluble form.. he 10th Tooth Morphogenesis and Differentiation 2010.09.01

  59. 永山友子、中原貴、太田正人、春日井昇平、井関祥子. FGFシグナルの胎児マウス頭蓋冠骨芽細胞分化に与える影響. 第３０回　日本炎症・再生医学会 2010.08.05

  60. 長岡亮介、奥原滋、天笠光雄、井関祥子. 胎児期低酸素状態が顔面形成に与える影響. 第50回　日本先天異常学会　学術集会 2010.07.08

  61. Masato S. Ota, Nobuyuki Itoh., Hiroki Kokubo , Astushi Ohazama, Yukishige Kozawa, Yumiko Saga,Paul T. Sharpe, Takashi Kondo, Taka Nakahara, Yoriaki Kanri , Takaaki Aoba, Sachiko Iseki . Wnt-signaling pathway is important for patterning of mammalian tooth roots in evolution and development.. 第43回日本発生生物学会年会 2010.06.20

  62. Nagayama S., Nakahara T. Ota MS. Iseki S.. FGF18 enhances osteogenesis of mouse fetal skull bone.. Gordon Research Conference " Fibroblast Growth Factors in Development & Disease " 2010.03.14

  63. Iseki S., Vivatbutsiri P., Okuhara S.. Involvement of Foxc1 in blood vessel formation of craniofacial region.. 第32回日本分子生物学会年会 2009.12.09

  64. 井関祥子. 頭蓋冠発生. 慈恵会医科大学、東京 2009.11.27

  65. Iseki S., Nakahara T., Ota M.. FGF18-induced osteoblast differentiation in developing mouse fetal calvaria.. he 26th NAITO Conference on Osteobiology 2009.11.04

  66. Shigeru Okuhara, Tomoko Sagai, Toshihiko Shiroishi, Sachiko Iseki　. Involvement of cis-regulatory element of sonic hedgehog in palatal　development　. 16th International Society of Developmental Biologists Congress 2009.09.06

  67. 鈴木 尋之、須田 直人、井関 祥子、森山 啓司. FGFR2IIIc-S252W及びSolubleの分化制御の検討. 第27回日本骨代謝学会 2009.07.23 大阪

  68. 大城暁子、中村さやか、井関祥子、川口陽子、篠村多摩之. 接合上皮に於けるFollicular Dendric Cell-Secreted Protein (FDC-SP)の特異的な発現とその機能に対する考察. 第52回春季日本歯周病学会　 2009.05.15

  69. Sachiko Iseki. Osteogenesis in mammalian craniofacial development. 2nd Thailand International Conference on Oral Biology 2009.05.07

  70. 鹿内弥磨、井関祥子、太田正人、齊藤佳子、寺岡弘文. Ex uteroマウス胎仔肝臓移植法を用いた肝臓前駆細胞の分化能解析. 第8回日本再生医療学会総会 2009.03.05

  71. 太田正人、小澤幸重、大峡淳、Sharpe P、井関祥子. 哺乳類の進化における吸指形態の多様化の分子機構の解析. 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会 2008.12.09

  72. Iseki S, Ichinose S., Vivatbutsiri P. . Impaired meningeal development is associated with defects in skull bone development in the Foxc1 mutant mouse. . 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会 2008.12.09

  73. 塗　隆志、上田晃一、井関祥子、太田正人、大場創介、奥原滋、三倉文子. Saethre-Chotzen症候群モデルマウスにおける頭蓋骨の成長. 第17回日本形成外科学会基礎学術集会 2008.10.02

  74. 太田正人、奥原滋、井関祥子. 歯根成長促進活性をもつ増殖因子と化合物の探索. 第50回歯科基礎医学会学術大会ならびに総会 2008.09.23

  75. 奥原滋、斎藤正寛、太田正人、井関祥子. tenascin-Nの骨芽細胞分化への関与. 第50回歯科基礎医学会学術大会ならびに総会 2008.09.23

  76. Iseki S., Ichinose S., Vivatbutsiri P.. Impaired meningeal development is associated with defects in skull bone development.. 第48回日本先天異常学会学術集会 2008.06.28

  77. Sachiko Iseki . Midface Formation. 3rd West-East Dental Conference 2008.05.29

  78. Sachiko Iseki, Shizuko Ichinose, Marjo Hytonen, Kirsi Sainio, Philaiporn Vivatbutsiri,. Maintenance of Twist-1 expression in the cranial mesenchyme of the Foxc1 mutant disturbs meningeal differentiation leading to impaired apical extension of skull bone osteogenesis Gordon Research Conference. "Craniofacial Morphogenesis & Tissue Regeneration" 2008.02.10

  79. Okuhara S., Iseki S.. Sonic hedgehog and Sall3 in tooth and palate development.. Gordon Research Conference "Craniofacial Morphogenesis & Tissue Regeneration" 2008.02.10

  80. 井関祥子. 哺乳類頭蓋顎顔面組織における頭部神経堤細胞と頭部中胚葉の局在について. 第66回日本矯正歯科学会大会　シンポジウム　 2007.09.19 大阪

  81. 井関祥子　Philaiporn Vivatbutsiri　相賀裕美子. 「頭蓋顔面組織形成時の組織相互作用を解析するツールとしての遺伝子改変マウス」. 第28回日本炎症・再生医学会　シンポジウム「神経堤細胞：成体幹細胞源としての可能性」 2007.08.02

  82. Iseki, S., Vivatbutsiri, P., Saga Y. . Contribution of mesoderm to mammalian craniofacial structure. 第47回日本先天異常学会学術集会 2007.07.07

  83. 三倉文子、斉藤正寛、太田正人、上田晃一、井関祥子. マウス頭蓋冠発生期縫合におけるtenascin-Nの発現. 第47回日本先天異常学会学術集会 2007.07.07

  84. Iseki S., Vivatbutsiri P., Hytonen M., Sainio K.. Developmental correlation between the meninges and calvarial bones 　. 第40回日本発生生物学会・第59回日本細胞生物学会合同大会 2007.05.28

  85. Vivatbutsiri P., Iseki S. Eto K.. Developmental correlation between the meninges and the calvarial bones.. 第48回歯科基礎医学会学術大会 2006.09.22

  86. seki S., Kriangkrai R., Chareonvit S., Yahagi K., Fujiwara M., and Eto K.. Study of Pax6 mutant rat recealed he association between upper incisor formation and facial cleft.. 第46回日本先天異常学会学術集会 2006.06.29

  87. 井関祥子、Philaiporn Vivatbutsiri、相賀裕美子、江藤一洋. Contribution of mesoderm to mammalian craniofacial structure. 第39回日本発生生物学会 2006.06.01

  88. Iseki S. Ichinose S. Hytnen M. Sainio K. Vivatbutsiri P.. Maintenance of Twist-1 expression in the cranial mesenchyme of the Foxc1 mutant disturbs meningeal differentiation leading to impaired apical extension of skull bone osteogenesis.. Gordon Research Conference "Craniofacial Morphogenesis & Tissue Regeneration" 2006.01.22

  89. Iseki S.. Mesoderm contribution to mouse craniofacial structure. Gordon Research Conference. Craniofacial Morphogenesis & Tissue Regeneration 2006.01.22 Ventura, Californ

  90. 井関祥子、江藤一洋. rSeyミュータントにおける過剰上顎切歯形成の解析. 第47回歯科基礎医学会学術大会 2005.09.28

  91. Sachiko Iseki . Mammalian skull development. King’s College London, UK 2005.09.20

  92. Sachiko Iseki. Mammalian skull development”.. University of Helsinki, Finland, 2005.09.12

  93. 井関祥子、Philaiporn Vivatbutsiri, 太田正人、江藤一洋. 発生過程における頭部組織幹細胞としての神経堤細胞の分化能について. 第26回炎症再生医学会 2005.07.12

  94. Sachiko Iseki. “Application of surgical and culture technique to study skull and palate development”. Research Technique in Bioengineering Room DT 2306 Faculty of Dentistry, Naresuan University, Phisanulok, Thailand, 2004.12.07

  95. 井関祥子. 頭蓋顎顔面の形態形成 頭蓋冠と切歯の発生-. 神奈川歯科大学、 2004.10.15

  96. Sachiko Iseki, Toshiyuki Yoshida, Isao Ishikawa, Kazuhiro Eto. Growth pattern of skull bones and involvement of BMPs in this process. 6th International Congress of International Federation of Associations of Anatomists Kyoto Japan 2004.08.23

  97. Rungarun Kriangkrai, Suconta Chareonvit, Michio Fujiwara, Koichi Yahagi, Kazuhiro Eto and Sachiko Iseki.. Involvement of maxillary process epithelium in rat maxillary incisor formation. . York, UK 2004.07.17

  98. Kriangkrai R., Chareonvit S., Fujiwara M., Yahagi K., Eto K. and Iseki S.. Involvement of maxillary process epithelium in rat maxillary incisor formation. Eighth International Conference on Tooth Morphogenesis and Differentiation 2004.07.17

  99. 葭田敏之、江藤一洋、井関祥子. 前頭骨は原器の成長によって形成され、この過程はBmp7によって促進される. 日本発生生物学会第37回大会 2004.06.05

  100. 井関祥子. 「頭蓋冠の発生」-由来組織と骨の成長-. 熊本大学 2004.05.11

  101. Rungarun Kriangkrai, Sachiko Iseki, Michio Fujiwara, Koichi Yahagi, Kazuhiro Eto and Suconta Chareonvit.. The study of supernumerary incisor formation in rSey rat. . 82nd General Session & Exhibition of the IADR 2004.05.10

  102. Iseki S.. BMP7 and frontal bone growth.. Gordon Research Conference "Craniofacial Morphogenesis & Tissue Regeneration" 2004.01.18

  103. 井関祥子. 頭蓋顔面の発生　-頭蓋冠の発生を中心に. 2003.10.28 徳島

  104. Nakahara T. Eto K. and Iseki S.. Effects of local application of osteogenesis related proteins to the developing skull vaults: FGF18 specifically enhanced osteogenesis in the osteogenic layer of the skull. . Kyoto University and the 4th Oxford-Kobe Biomedical Science Joint International Symposium "FGFs and Their Receptors in Health and Disease" 2003.10.12

  105. Nakahara T. Eto K. and Iseki S.. Effects of local application of osteogenesis related proteins to the developing skull vaults: FGF18 specifically enhanced osteogenesis in the osteogenic layer of the skull.. Kyoto University and the 4th Oxford-Kobe Biomedical Science Joint International Symposium "FGFs and Their Receptors in Health and Disease" 2003.10.12

  106. 井関祥子. Human Frontier Science Program Awardees' Annual Meeting. Robinson College Cambridge, UK 2003.07.06

  107. 葭田敏之、石川烈、江藤一洋、井関祥子. 髄膜は頭蓋冠の骨の成長に必要である. 日本発生生物学会第36回大会 2003.06.11

  108. Yoshida T., Iseki S., Phylactou L.A., Uney J.B., Ishikawa I. and Eto K.. Meninges play an essential role in skull development.. 1st Joint Meeting of the International Bone and Mineral Society (IBMS) and the Japanese Society for Bone and Mineral Research (JSBMR) 2003.06.03

  109. Yoshida T., Iseki S., Phylactou L.A., Uney J.B., Ishikawa I. and Eto K.. Meninges play an essential role in skull development. 1st Joint Meeting of the International Bone and Mineral Society (IBMS) and the Japanese Society for Bone and Mineral Research (JSBMR) 2003.06.03 Osaka

  110. 葭田敏之、井関祥子、石川烈、江藤一洋. アデノウイルスベクターを用いたマウス胎児頭蓋冠における遺伝子発現調節. 第44回歯科基礎医学会学術大会 2002.10.03

  111. 井関祥子. Human Frontier Science Program Awardees' Annual Meeting. Human Frontier Science Program Awardees' Annual Meeting 2002.07.06

  112. 井関祥子、葭田敏之、江藤一洋、Gillian Morriss-Kay. 指の形成における線維芽細胞増殖因子受容体の役割. 日本発生生物学会第35回大会 2002.05.21

  113. Jiang X., Iseki S., Maxon R.E., Sucov H.M. and Morriss-Kay G.M.. Neural crest-mesoderm boundaries in the mammalian skull vault.. British Society for Developmental Biology Autumn Meeting. 2001.09.21

  114. 井関祥子、高橋英至、葭田敏之、石川烈、秦維郎、江藤一洋. マウス頭蓋冠縫合部における細胞分化調節の検討. 第22回日本炎症・再生医学会 2001.07.02

  115. Iseki S, Eto K and Morriss-Kay GM.. Genetic Control of Skull Vault Development: Roles of Fibroblast Growth Factor Receptor Signalling. 79th International Association for Dental Research, Chiba Japan, 2001.06.29

  116. 井関祥子. 線維芽細胞増殖因子受容体と頭蓋冠発生. 明海大学 2001.03.27

  117. S. Iseki, K Eto and G.M. Morriss-Kay. "Roles of Fibroblast Growth Factor Receptor signalling in skull development" . Japanese Association for Dental Research 48th annual meeting Matsudo, Chiba 2000.12.03

  118. Iseki S, Morriss-Kay GM, Eto K. Study of fibroblast growth factor receptor signalling during skull vault development by ex-utero surgery. Japan, at Asian Science Seminar in Okayama 2000 2000.08.29 Okayama

  119. Iseki S., Johnson D., Wilkie A.O.M. and Morriss-Kay G.M.. Genetic control of the cell proliferation-differentiation balance in the developing skull vault. British Society for Developmental Biology Autumn Meeting. 1999.09.15

  120. Iseki S. and Morriss-Kay G.M.. Differentiation and Proliferation-Related Roles of Fibroblast Growth Factor Receptor 1 and 2 Signalling in the Developing Mouse Skul. . oward A Molecular Understanding of Craniiofacial Morphogenesis An International Symposium at National Institutes of Health. 1998.11.22

  121. Iseki S., Ishii-Suzuki M., Maruyama K., Kuroda T., Obata K. and Eto K.. Roles of Gad67 in Secondary Palate Development. 76th General Session of IADR. 1998.06.22

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