Personnel Information

写真a

MIURA Masahiko


Job title

Professor

Homepage URL

http://www.tmd.ac.jp/mdth/index.html

Research Areas, Keywords

radiation oncology, radiation biology, radiotherapy for oral carcinoma, brachytherapy, radiosensitivity, cell cycle, molecular imaging, angiogenesis, radiosensitizer

Graduating School 【 display / non-display

  • Tohoku University, Faculty of Dentistry, 1987.03, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Graduate School, Division of Dental Research, Doctor's Course, 1991.03, Completed

Degree 【 display / non-display

  • Ph.D, Tokyo Medical and Dental University

Campus Career 【 display / non-display

  • 1994.10
    -
    1995.02
    Tokyo Medical and Dental University, Faculty of Dentistry, Dental Resident
  • 2007.04
    -
    2008.08
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Oral Health Sciences, Oral Radiation Oncology, Associate Professor
  • 2008.09
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Oral Health Sciences, Oral Radiation Oncology, Professor

External Career 【 display / non-display

  • 2006.09
    -
    2017.03
    , Visiting Lecturer
  • 2009.04
    -
    2010.03
    , Visiting Lecturer
  • 2010.01
    -
    2011.02
    , Visiting Lecturer
  • 2012.07
    -
    Now
    , Visiting Lecturer

Research Areas 【 display / non-display

  • Oral pathobiological science

  • Radiological sciences

 

Published Papers & Misc 【 display / non-display

  1. Yoshihide Ota, Tadahide Noguchi, Masahiko Miura et al.. General rules for clinical and pathological studies on oral cancer (2nd edition): a synopsis. Int J Clin Oncol. 2021.04; 26 (4): 623-635. ( PubMed, DOI )

  2. Kabasawa Yuji, Ito Kanade, Tokura Shiori, Takazawa Itsuki, Kimura Rio, Nakanishi Tohko, Akiyama Kikue, Onuma Yuki, Adachi Toshiko, Komiya Ruri, Harada Hiroyuki, Nojima Hitomi, Miura Masahiko, Yoshimura Ryoichi. Clinical Investigation of Episil Oral Solution for Oral Mucositis during Radiochemical Treatment for Head and Neck Cancer 日本口腔ケア学会雑誌. 2021.04; 15 (3): 264. ( ichushi )

  3. Kohei Okuyama, Keiji Suzuki, Tomofumi Naruse, Hiroki Tsuchihashi, Souichi Yanamoto, Atsushi Kaida, Masahiko Miura, Masahiro Umeda, Shunichi Yamashita. Prolonged cetuximab treatment promotes p27 Kip1-mediated G1 arrest and autophagy in head and neck squamous cell carcinoma. Sci Rep. 2021.03; 11 (1): 5259. ( PubMed, DOI )

  4. Hiroaki Shimono, Atsushi Kaida, Hisao Homma, Hitomi Nojima, Yusuke Onozato, Hiroyuki Harada, Masahiko Miura. Fluctuation in radioresponse of HeLa cells during the cell cycle evaluated based on micronucleus frequency. Sci Rep. 2020.11; 10 (1): 20873. ( PubMed, DOI )

  5. Hideaki Hirai, Toshimitsu Ohsako, Takuma Kugimoto, Hirofumi Tomioka, Yasuyuki Michi, Kou Kayamori, Tetsuya Yoda, Masahiko Miura, Ryoichi Yoshimura, Hiroyuki Harada. Comparison of 50- and 66-Gy total irradiation doses for postoperative cervical treatment of patients with oral squamous cell carcinoma Oral Oncol. 2020.08; 107 104708. ( PubMed, DOI )

  6. Nojima Hitomi, Homma Hisao, Onozato Yusuke, Kaida Atsushi, Harada Hiroyuki, Miura Masahiko. Differential properties of mitosis-associated events following CHK1 and WEE1 inhibitor treatments in human tongue carcinoma cells EXPERIMENTAL CELL RESEARCH. 2020.01; 386 (2): 111720. ( PubMed, DOI )

  7. Hisao Homma, Hitomi Nojima, Atsusi Kaida, Masahiko Miura. Induction of endomitosis-like event in HeLa cells following CHK1 inhibitor treatment Biochem Biophys Res Commun. 2019.12; 520 (2): 492-497. ( PubMed )

  8. Goto T, Homma H, Kaida A, Miura M. WEE1 inhibition enhances sensitivity to hypoxia/reoxygenation in HeLa cells. J Radiat Res. 2019.09; 60 (5): 714-718. ( PubMed, DOI )

  9. 三浦雅彦, 戒田篤志. 放射線照射後の腫瘍細胞における再分布動態の可視化とその臨床的意義 放射線生物研究. 2018.12; 53 (4): 265-279.

  10. Yoichi Takakusagi, Sarwat Naz, Kaori Takakusagi, Masahiro Ishima, Hiroshi Murata, Keisuke Ohta, Masahiko Miura, Fumio Sugawara, Kengo Sakaguchi, Shun Kishimoto, Jeeva P Munasinghe, James B Mitchell, Murali C Krishna. A Multimodal Molecular Imaging Study Evaluates Pharmacological Alteration of the Tumor Microenvironment to Improve Radiation Response. Cancer Res.. 2018.12; 78 (24): 6828-6837. ( PubMed, DOI )

  11. Nisha Gowri Manila, Atsushi Kaida, Ken-Ichi Nakahama, Masahiko Miura. Insulin-like growth factor I receptor regulates the radiation-induced G2/M checkpoint in HeLa cells. Biochem. Biophys. Res. Commun.. 2018.08; 503 (4): 2977-2987. ( PubMed, DOI )

  12. Sirimanas Jiaranuchart, Atsushi Kaida, Yusuke Onozato, Hiroyuki Harada, Masahiko Miura. DNA damage response following X-irradiation in oral cancer cell lines HSC3 and HSC4. Arch. Oral Biol.. 2018.06; 90 1-8. ( PubMed, DOI )

  13. Tatsushi Ruike, Yoshihiro Kanai, Kazuki Iwabata, Yuki Matsumoto, Hiroshi Murata, Masahiro Ishima, Keisuke Ohta, Masahiko Oshige, Shinji Katsura, Koji Kuramochi, Shinji Kamisuki, Hiroeki Sahara, Masahiko Miura, Fumio Sugawara, Kengo Sakaguchi. Distribuiton and metabolism of 14C Sulfoquinovosylacylpropanediol (14C-SQAP) after a single intravenous administration in tumor-bearing mice. Xenobiotica. 2018.03; 1-45. ( PubMed, DOI )

  14. Sato M, Saito Y, Takayama T, Omata T, Watanabe H, Yoshimura R, Miura M.. Remote radioactive seed-loading device for permanent brachytherapy of oral cancer with Au-198 grains. Robomech Journal. 2017.09; 4 23.

  15. Atsushi Kaida, Hiroshi Watanabe, Kazuma Toda, Keiko Yuasa-Nakagawa, Ryoichi Yoshimura, Masahiko Miura. Effects of dose rate on early and late complications in low dose rate brachytherapy for mobile tongue carcinoma using Ir-192 sources. Oral Radiol. 2017.09; 33 (3): 187-192. ( DOI )

  16. Atsushi Oba, Shu Shimada, Yoshimitsu Akiyama, Taketo Nishikawaji, Kaoru Mogushi, Hiromitsu Ito, Satoshi Matsumura, Arihiro Aihara, Yusuke Mitsunori, Daisuke Ban, Takanori Ochiai, Atsushi Kudo, Hiroshi Asahara, Atsushi Kaida, Masahiko Miura, Minoru Tanabe, Shinji Tanaka. ARID2 modulates DNA damage response in human hepatocellular carcinoma cells. J. Hepatol.. 2017.05; 66 (5): 942-951. ( PubMed, DOI )

  17. Yusuke Onozato, Atsushi Kaida, Hiroyuki Harada, Masahiko Miura. Radiosensitivity of quiescent and proliferating cells grown as multicellular tumor spheroids. Cancer Sci. 2017.04; 108 (4): 704-712. ( PubMed, DOI )

  18. Manila Nisha Gowri, Kaida Atsushi, Miura Masahiko. 照射後HeLa細胞におけるインシュリン様成長因子I受容体(IGF-IR)の役割(Roles of insulin-like growth factor I receptor(IGF-IR) in HeLa cells following irradiation) 口腔病学会雑誌. 2017.03; 84 (1): 51. ( ichushi )

  19. Y Ozaki, H Watanabe, A Kaida, M Miura, K Nakagawa, K Toda, R Yoshimura, Y Sumi, T Kurabayashi. Estimation of whole-body radiation exposure from brachytherapy for oral cancer using a Monte Carlo simulation. J. Radiat. Res.. 2017.02; 24 1-6. ( PubMed, DOI )

  20. Nisha Gowri Manila, Atsushi Kaida, Masahiko Miura. Kinetic analysis of radiation-induced cell-cycle alterations in HeLa cells expressing fluorescent ubiquitination-based cell cycle indicator (Fucci). Radiat Environ Med. 2016.08; 5 (2): 16-21.

  21. Taito Asahina, Atsushi Kaida, Tatsuaki Goto, Ryo-Ichi Yoshimura, Keisuke Sasai, Masahiko Miura. Temporo-spatial cell-cycle kinetics in HeLa cells irradiated by Ir-192 high dose-rate remote afterloading system (HDR-RALS). Radiat Oncol. 2016.07; 11 99. ( PubMed, DOI )

  22. Kohei Okuyama, Atsushi Kaida, Yoshiki Hayashi, Yoshio Hayashi, Kiyoshi Harada, Masahiko Miura. KPU-300, a Novel Benzophenone-Diketopiperazine-Type Anti-Microtubule Agent with a 2-Pyridyl Structure, Is a Potent Radiosensitizer That Synchronizes the Cell Cycle in Early M Phase. PLoS ONE. 2015.12; 10 (12): e0145995. ( PubMed, DOI )

  23. Tatsuaki Goto, Atsushi Kaida, Masahiko Miura. Visualizing cell-cycle kinetics after hypoxia/reoxygenation in HeLa cells expressing fluorescent ubiquitination-based cell cycle indicator (Fucci). Exp. Cell Res.. 2015.12; 339 (2): 389-396. ( PubMed, DOI )

  24. Atsushi Kaida, Masahiko Miura. Unusual prolongation of radiation-induced G2 arrest in tumor xenografts derived from HeLa cells. Cancer Sci. 2015.10; 106 (10): 1370-1376. ( PubMed, DOI )

  25. Jesus Izaguirre-Carbonell, Hirofumi Kawakubo, Hiroshi Murata, Atsushi Tanabe, Toshifumi Takeuchi, Tomoe Kusayanagi, Senko Tsukuda, Takeshi Hirakawa, Kazuki Iwabata, Yoshihiro Kanai, Keisuke Ohta, Masahiko Miura, Kengo Sakaguchi, Sachihiro Matsunaga, Hiroeki Sahara, Shinji Kamisuki, Fumio Sugawara. Novel anticancer agent, SQAP, binds to focal adhesion kinase and modulates its activity. Sci Rep. 2015.10; 5 15136. ( PubMed, DOI )

  26. Yugo Sawada, Kazuya Omoto, Naoki Kohei, Kengo Sakaguchi, Masahiko Miura, Kazunari Tanabe. Sulfoquinovosylacylpropanediol is a novel potent radiosensitizer in prostate cancer. Int. J. Urol.. 2015.06; 22 (6): 590-595. ( PubMed, DOI )

  27. Eri Tsuchida, Atsushi Kaida, Endrawan Pratama, Masa-Aki Ikeda, Keiji Suzuki, Kiyoshi Harada, Masahiko Miura. Effect of X-Irradiation at Different Stages in the Cell Cycle on Individual Cell-Based Kinetics in an Asynchronous Cell Population. PLoS ONE. 2015.06; 10 (6): e0128090. ( PubMed, DOI )

  28. Chisato Yamada, Atsushi Kaida, Kohei Okuyama, Kiyoshi Harada, Masahiko Miura. Effects of Chk1 inhibitor or paclitaxel on cisplatin-induced cell-cycle kinetics and survival in parental and cisplatin-resistant HeLa cells expressing fluorescent ubiquitination based cell cycle indicator (Fucci). Integr Cancer Sci Therap. 2015.02; 2 87-92.

  29. Lian Xue, Yoshiya Furusawa, Ryuichi Okayasu, Masahiko Miura, Xing Cui, Cuihua Liu, Ryoichi Hirayama, Yoshitaka Matsumoto, Hirohiko Yajima, Dong Yu. The complexity of DNA double strand break is a crucial factor for activating ATR signaling pathway for G2/M checkpoint regulation regardless of ATM function. DNA Repair (Amst.). 2015.01; 25 72-83. ( PubMed, DOI )

  30. Eslami A, Miyagushi K, Mogushi K, Watanabe H, Okada N, Shibuya H, Mizushima H, Miura M, Tanaka H.. PARVB overexertion increased cell migration capability and defines high risk for endophytic growth and metastasis in tongue squamous cell carcinoma. British Journal of Cancer. 2014.11; ( DOI )

  31. Yoshiki Hayashi, Haruka Takeno, Takumi Chinen, Kyohei Muguruma, Kohei Okuyama, Akihiro Taguchi, Kentaro Takayama, Fumika Yakushiji, Masahiko Miura, Takeo Usui, Yoshio Hayashi. Development of a new benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a 2-pyridine structure. ACS Med Chem Lett. 2014.10; 5 (10): 1094-1098. ( PubMed, DOI )

  32. Kamrun Nahar, Tatsuaki Goto, Atsushi Kaida, Shifumi Deguchi, Masahiko Miura. Effects of Chk1 inhibition on the temporal duration of radiation-induced G2 arrest in HeLa cells. J. Radiat. Res.. 2014.09; 55 (5): 1021-1027. ( PubMed, DOI )

  33. Atsushi Kaida, Masahiko Miura. Visualizing the effect of tumor microenvironments on radiation-induced cell kinetics in multicellular spheroids consisting of HeLa cells. Biochem. Biophys. Res. Commun.. 2013.10; 439 (4): 453-458. ( PubMed, DOI )

  34. Keiko Yuasa-Nakagawa, Hitoshi Shibuya, Ryoichi Yoshimura, Masahiko Miura, Hiroshi Watanabe, Seiji Kishimoto, Ken Omura. Cervical lymph node metastasis from early-stage squamous cell carcinoma of the oral tongue. Acta Otolaryngol.. 2013.05; 133 (5): 544-551. ( PubMed, DOI )

  35. Asumi Honda-Uezono, Atsushi Kaida, Yasuyuki Michi, Kiyoshi Harada, Yoshiki Hayashi, Yoshio Hayashi, Masahiko Miura. Unusual expression of red fluorescence at M phase induced by anti-microtubule agents in HeLa cells expressing the fluorescent ubiquitination-based cell cycle indicator (Fucci). Biochem. Biophys. Res. Commun.. 2012.11; 428 (2): 224-229. ( PubMed, DOI )

  36. Shigehiro Abe, Keiichi Hamada, Masahiko Miura, Satoshi Yamaguchi. Neural crest stem cell property of apical pulp cells derived from human developing tooth. Cell Biol. Int.. 2012.10; 36 (10): 927-936. ( PubMed, DOI )

  37. Yuka Miyano, Senko Tsukuda, Ippei Sakimoto, Ryo Takeuchi, Satomi Shimura, Noriyuki Takahashi, Tomoe Kusayanagi, Yoichi Takakusagi, Mami Okado, Yuki Matsumoto, Kaori Takakusagi, Toshifumi Takeuchi, Shinji Kamisuki, Atsuo Nakazaki, Keisuke Ohta, Masahiko Miura, Kouji Kuramochi, Yoshiyuki Mizushina, Susumu Kobayashi, Fumio Sugawara, Kengo Sakaguchi. Exploration of the binding proteins of perfluorooctane sulfonate by a T7 phage display screen. Bioorg. Med. Chem.. 2012.07; 20 (13): 3985-3990. ( PubMed, DOI )

  38. Atsushi Kaida, Masahiko Miura. Differential dependence on oxygen tension during the maturation process between monomeric Kusabira Orange 2 and monomeric Azami Green expressed in HeLa cells. Biochem. Biophys. Res. Commun.. 2012.05; 421 (4): 855-859. ( PubMed, DOI )

  39. Kaida A, Miura M. Visualizing the effect of hypoxia on fluorescence kinetics in living HeLa cells using the fluorescent ubiquitination-based cell cycle indicator (Fucci). Exp Cell Res. 2012.02; 318 (3): 288-297. ( PubMed, DOI )

  40. Yoshimura RI, Shibuya H, Hayashi K, Nakagawa K, Toda K, Watanabe H, Kaida A, Miura M. Repeat Brachytherapy for Patients with Residual or Recurrent Tumors of Oral Cavity. Int J Radiat Oncol Biol Phys. 2011.11; ( PubMed, DOI )

  41. Yoshimura R, Shibuya H, Hayashi K, Toda K, Watanabe H, Miura M. Disease control using low-dose-rate brachytherapy is unaffected by comorbid severity in oral cancer patients. Br J Radiol. 2011.10; 84 (1006): 930-938. ( PubMed, DOI )

  42. Nakayama M, Kaida A, Deguchi S, Sakaguchi K, Miura M. Radiosensitivity of early and late M-phase HeLa cells isolated by a combination of fluorescent ubiquitination-based cell cycle indicator (Fucci) and mitotic shake-off. Radiat Res. 2011.09; 176 (3): 407-411. ( PubMed )

  43. Kaida A, Sawai N, Sakaguchi K, Miura M. Fluorescence kinetics in HeLa cells after treatment with cell cycle arrest inducers visualized with Fucci (fluorescent ubiquitination-based cell cycle indicator). Cell Biol Int. 2011.04; 35 (4): 359-363. ( PubMed, DOI )

  44. Abe S, Hamada K, Yamaguchi S, Amagasa T, Miura M. Characterization of the radioresponse of human apical papilla-derived cells. Stem Cell Res Ther. 2011; 2 (1): 2. ( PubMed, DOI )

  45. Ohta K, Murata H, Mori Y, Ishima M, Sugawara F, Sakaguchi K, Miura M. Remodeling of the tumor microenvironment by combined treatment with a novel radiosensitizer, {alpha}-sulfoquinovosylmonoacylglycerol ({alpha}-SQMG) and X-irradiation. Anticancer Res. 2010.11; 30 (11): 4397-4404. ( PubMed )

  46. Ishikawa M, Ogihara Y, Miura M. Visualization of radiation-induced cell cycle-associated events in tumor cells expressing the fusion protein of Azami Green and the destruction box of human Geminin. Biochem Biophys Res Commun. 2009.11; 389 (3): 426-430. ( PubMed, DOI )

  47. Sermsathanasawadi N, Ishii H, Igarashi K, Miura M, Yoshida M, Inoue Y, Iwai T. Enhanced adhesion of early endothelial progenitor cells to radiation-induced senescence-like vascular endothelial cells in vitro. J Radiat Res. 2009.09; 50 (5): 469-475. ( PubMed )

  48. Miura M. [Radiotherapy for oral tumors and translational research]. Kokubyo Gakkai Zasshi. 2009.03; 76 (1): 8-15. ( PubMed )

  49. Igarashi K, Miura M. Inhibition of a radiation-induced senescence-like phenotype: a possible mechanism for potentially lethal damage repair in vascular endothelial cells. Radiat Res. 2008.10; 170 (4): 534-539. ( PubMed )

  50. Watanabe H, Mogushi K, Miura M, Yoshimura R, Kurabayashi T, Shibuya H, Tanaka H, Noda S, Iwakawa M, Imai T. Prediction of lymphatic metastasis based on gene expression profile analysis after brachytherapy for early-stage oral tongue carcinoma. Radiother Oncol. 2008.05; 87 (2): 237-242. ( PubMed, DOI )

  51. Kaneko H, Yu D, Miura M. Overexpression of IGF-I receptor in HeLa cells enhances in vivo radioresponse. Biochem Biophys Res Commun. 2007.11; 363 (4): 937-941. ( PubMed, DOI )

  52. Igarashi K, Sakimoto I, Kataoka K, Ohta K, Miura M. Radiation-induced senescence-like phenotype in proliferating and plateau-phase vascular endothelial cells. Exp Cell Res. 2007.09; 313 (15): 3326-3336. ( PubMed, DOI )

  53. Ayukawa F, Shibuya H, Yoshimura R, Watanabe H, Miura M. Curative brachytherapy for recurrent/residual tongue cancer. Strahlenther Onkol. 2007.03; 183 (3): 133-137. ( PubMed, DOI )

  54. Miura M, Sakimoto I, Ohta K, Sugawara F, Sakaguchi K. Sulfoglycolipids as candidate antiangiogenic radiosensitizers. Anticancer Drugs. 2007.01; 18 (1): 1-5. ( PubMed, DOI )

  55. Sakimoto I, Ohta K, Yamazaki T, Ohtani S, Sahara H, Sugawara F, Sakaguchi K, Miura M. Alpha-sulfoquinovosylmonoacylglycerol is a novel potent radiosensitizer targeting tumor angiogenesis. Cancer Res. 2006.02; 66 (4): 2287-2295. ( PubMed, DOI )

  56. Watanabe H, Murata Y, Miura M, Hasegawa M, Kawamoto T, Shibuya H. In-vivo visualization of radiation-induced apoptosis using (125)I-annexin V. Nucl Med Commun. 2006.01; 27 (1): 81-89. ( PubMed )

  57. Kaneko H, Igarashi K, Kataoka K, Miura M. Heat shock induces phosphorylation of histone H2AX in mammalian cells. Biochem Biophys Res Commun. 2005.03; 328 (4): 1101-1106. ( PubMed, DOI )

  58. Ihara N, Shibuya H, Yoshimura R, Oota S, Miura M, Watanabe H. Interstitial brachytherapy and neck dissection for Stage III squamous cell carcinoma of the mobile tongue. Acta Oncol. 2005; 44 (7): 709-716. ( PubMed, DOI )

  59. Kuribayashi A, Kataoka K, Kurabayashi T, Miura M. Evidence that basal activity, but not transactivation, of the epidermal growth factor receptor tyrosine kinase is required for insulin-like growth factor I-induced activation of extracellular signal-regulated kinase in oral carcinoma cells. Endocrinology. 2004.11; 145 (11): 4976-4984. ( PubMed, DOI )

  60. Hoshina M, Shibuya H, Kubo HD, Miura M, Ohashi I, Yoshimura R, Oota S. Determination of the depth of 50% of maximum ionization, I50, for electron beams by the divided difference method. Med Phys. 2004.07; 31 (7): 2068-2074. ( PubMed )

  61. Watanabe H, Kurabayashi T, Miura M. Inhibition of the extracellular signal-regulated kinase (ERK) pathway and the induction of radioresistance in rat 3Y1 cells. Int J Radiat Biol. 2004.06; 80 (6): 451-457. ( PubMed, DOI )

  62. Kataoka K, Yu D, Miura M. Activation of the phosphatidylinositol-3' kinase pathway and DNA synthesis by a mutant insulin-like growth factor I receptor lacking the NPXY motif. J Endocrinol. 2004.04; 181 (1): 139-146. ( PubMed )

  63. Kataoka K, Miura M. Insulin-like growth factor I receptor does not contribute to heat shock-induced Activation of Akt and extracellular signal-regulated kinase (ERK) in mouse embryo fibroblasts. J Radiat Res. 2004.03; 45 (1): 141-144. ( PubMed )

  64. Yu D, Shibuya H, Miura M. Roles of the insulin-like growth factor I receptor C-terminus in cellular radioresistance. Biochem Biophys Res Commun. 2003.11; 311 (1): 174-178. ( PubMed )

  65. Nakagawa T, Shibuya H, Yoshimura R, Miura M, Okada N, Kishimoto S, Amagasa M, Omura K. Neck node metastasis after successful brachytherapy for early stage tongue carcinoma. Radiother Oncol. 2003.08; 68 (2): 129-135. ( PubMed )

  66. Yu D, Watanabe H, Shibuya H, Miura M. Redundancy of radioresistant signaling pathways originating from insulin-like growth factor I receptor. J Biol Chem. 2003.02; 278 (9): 6702-6709. ( PubMed, DOI )

  67. Dong Y, Watanabe H, Shibuya H, Miura M. The phosphatidylinositol-3 kinase pathway is not essential for insulin-like growth factor I receptor-mediated clonogenic radioresistance. J Radiat Res. 2002.09; 43 (3): 325-329. ( PubMed )

  68. Imoto I, Tsuda H, Hirasawa A, Miura M, Sakamoto M, Hirohashi S, Inazawa J. Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy. Cancer Res. 2002.09; 62 (17): 4860-4866. ( PubMed )

  69. Miura M. [Relationship between apoptotic activity and radiosensitivity in solid tumors: does apoptosis always bring good clinical results?]. Nihon Igaku Hoshasen Gakkai Zasshi. 2002.09; 62 (10): 545-548. ( PubMed )

  70. Watanabe H, Yu D, Sasaki T, Shibuya H, Hosoi Y, Asada M, Komatsu K, Miura M. Insulin-like growth factor I receptor is expressed at normal levels in Nijmegen breakage syndrome cells. Biochem Biophys Res Commun. 2002.08; 296 (1): 62-66. ( PubMed )

  71. Yoshimura R, Shibuya H, Ogura I, Miura M, Amagasa T, Enomoto S, Kishimoto S. Trimodal combination therapy for maxillary sinus carcinoma. Int J Radiat Oncol Biol Phys. 2002.07; 53 (3): 656-663. ( PubMed )

  72. Yamamoto E, Shibuya H, Yoshimura R, Miura M. Site specific dependency of second primary cancer in early stage head and neck squamous cell carcinoma. Cancer. 2002.04; 94 (7): 2007-2014. ( PubMed )

  73. Tezuka M, Watanabe H, Nakamura S, Yu D, Aung W, Sasaki T, Shibuya H, Miura M. Antiapoptotic activity is dispensable for insulin-like growth factor I receptor-mediated clonogenic radioresistance after gamma-irradiation. Clin Cancer Res. 2001.10; 7 (10): 3206-3214. ( PubMed )

  74. Aoki A, Miura M, Akiyama F, Nakagawa N, Tanaka J, Oda S, Watanabe H, Ishikawa I. In vitro evaluation of Er:YAG laser scaling of subgingival calculus in comparison with ultrasonic scaling. J Periodontal Res. 2000.10; 35 (5): 266-277. ( PubMed )

  75. Miura M, Watanabe H, Okochi K, Sasaki T, Shibuya H. Biological response to ionizing radiation in mouse embryo fibroblasts with a targeted disruption of the DNA polymerase beta gene. Radiat Res. 2000.06; 153 (6): 773-780. ( PubMed )

  76. Yoshimura R, Shibuya H, Hoshina M, Akaike H, Takeda M, Fukuda H, Hoshi A, Miura M. Successful interstitial treatment for bilateral tongue cancer. Br J Radiol. 1999.08; 72 (860): 812-814. ( PubMed )

  77. Watanabe H, Miura M, Sasaki T. Differential effects of the insulin-like growth factor I receptor on radiosensitivity and spontaneous necrosis formation of human glioblastoma cells grown in multicellular spheroids. Exp Cell Res. 1999.07; 250 (1): 99-111. ( PubMed, DOI )

  78. Miura M. Detection of chromatin-bound PCNA in mammalian cells and its use to study DNA excision repair. J Radiat Res. 1999.03; 40 (1): 1-12. ( PubMed )

  79. Miura M, Sasaki T. Detection of chromatin-bound PCNA in cultured cells following exposure to DNA-damaging agents. Methods Mol Biol. 1999; 113 577-582. ( PubMed, DOI )

  80. Miura M, Takeda M, Sasaki T, Inoue T, Nakayama T, Fukuda H, Hoshi A, Hoshina M, Shibuya H. Factors affecting mandibular complications in low dose rate brachytherapy for oral tongue carcinoma with special reference to spacer. Int J Radiat Oncol Biol Phys. 1998.07; 41 (4): 763-770. ( PubMed )

  81. Miura M, Baserga R. The tyrosine residue at 1250 of the insulin-like growth factor I receptor is required for ligand-mediated internalization. Biochem Biophys Res Commun. 1997.10; 239 (1): 182-185. ( PubMed, DOI )

  82. Nakamura S, Watanabe H, Miura M, Sasaki T. Effect of the insulin-like growth factor I receptor on ionizing radiation-induced cell death in mouse embryo fibroblasts. Exp Cell Res. 1997.08; 235 (1): 287-294. ( PubMed, DOI )

  83. Miura M, Sasaki T. Effect of XPA gene mutations on UV-induced immunostaining of PCNA in fibroblasts from xeroderma pigmentosum group A patients. Mutat Res. 1996.09; 364 (1): 51-56. ( PubMed )

  84. Miura M, Nakamura S, Sasaki T, Takasaki Y, Shiomi T, Yamaizumi M. Roles of XPG and XPF/ERCC1 endonucleases in UV-induced immunostaining of PCNA in fibroblasts. Exp Cell Res. 1996.07; 226 (1): 126-132. ( PubMed, DOI )

  85. Hongo A, D'Ambrosio C, Miura M, Morrione A, Baserga R. Mutational analysis of the mitogenic and transforming activities of the insulin-like growth factor I receptor. Oncogene. 1996.03; 12 (6): 1231-1238. ( PubMed )

  86. Miura M, Sasaki T, Takasaki Y. Characterization of X-ray-induced immunostaining of proliferating cell nuclear antigen in human diploid fibroblasts. Radiat Res. 1996.01; 145 (1): 75-80. ( PubMed )

  87. Miura M, Surmacz E, Burgaud JL, Baserga R. Different effects on mitogenesis and transformation of a mutation at tyrosine 1251 of the insulin-like growth factor I receptor. J Biol Chem. 1995.09; 270 (38): 22639-22644. ( PubMed )

  88. Miura M, Li S, Baserga R. Effect of a mutation at tyrosine 950 of the insulin-like growth factor I receptor on the growth and transformation of cells. Cancer Res. 1995.02; 55 (3): 663-667. ( PubMed )

  89. Li S, Ferber A, Miura M, Baserga R. Mitogenicity and transforming activity of the insulin-like growth factor-I receptor with mutations in the tyrosine kinase domain. J Biol Chem. 1994.12; 269 (51): 32558-32564. ( PubMed )

  90. Coppola D, Ferber A, Miura M, Sell C, D'Ambrosio C, Rubin R, Baserga R. A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor. Mol Cell Biol. 1994.07; 14 (7): 4588-4595. ( PubMed )

  91. Sell C, Dumenil G, Deveaud C, Miura M, Coppola D, DeAngelis T, Rubin R, Efstratiadis A, Baserga R. Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. Mol Cell Biol. 1994.06; 14 (6): 3604-3612. ( PubMed )

  92. Miura M, Li SW, Dumenil G, Baserga R. Platelet-derived growth factor-induced expression of messenger RNA for the proliferating cell nuclear antigen requires a functional receptor for the insulin-like growth factor I. Cancer Res. 1994.05; 54 (9): 2472-2477. ( PubMed )

  93. Ambrose D, Resnicoff M, Coppola D, Sell C, Miura M, Jameson S, Baserga R, Rubin R. Growth regulation of human glioblastoma T98G cells by insulin-like growth factor-1 and its receptor. J Cell Physiol. 1994.04; 159 (1): 92-100. ( PubMed, DOI )

  94. Yoshinouchi M, Miura M, Gaozza E, Li SW, Baserga R. Basic fibroblast growth factor stimulates DNA synthesis in cells overexpressing the insulin-like growth factor-I receptor. Mol Endocrinol. 1993.09; 7 (9): 1161-1168. ( PubMed )

  95. Miura M, Domon M, Sasaki T, Kondo S, Takasaki Y. Restoration of proliferating cell nuclear antigen (PCNA) complex formation in xeroderma pigmentosum group A cells following cis-diamminedichloroplatinum (II)-treatment by cell fusion with normal cells. J Cell Physiol. 1992.09; 152 (3): 639-645. ( PubMed, DOI )

  96. Miura M, Domon M, Sasaki T, Kondo S, Takasaki Y. Two types of proliferating cell nuclear antigen (PCNA) complex formation in quiescent normal and xeroderma pigmentosum group A fibroblasts following ultraviolet light (uv) irradiation. Exp Cell Res. 1992.08; 201 (2): 541-544. ( PubMed )

  97. Miura M, Domon M, Sasaki T, Takasaki Y. Induction of proliferating cell nuclear antigen (PCNA) complex formation in quiescent fibroblasts from a xeroderma pigmentosum patient. J Cell Physiol. 1992.02; 150 (2): 370-376. ( PubMed, DOI )

  98. Miura M, Sasaki T. Role of glutathione in the intrinsic radioresistance of cell lines from a mouse squamous cell carcinoma. Radiat Res. 1991.05; 126 (2): 229-236. ( PubMed )

  99. Miura M, Sasaki T. Relationship between radiosensitivity and metallothionein content in clones from a mouse squamous cell carcinoma. Radiat Res. 1990.08; 123 (2): 171-175. ( PubMed )

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Books etc 【 display / non-display

  1. Atsushi Kaida, Masahiko Miura. Cell Cycle Oscillators. Springer Nature, 2021.06 Visualization of Radiation-Induced Cell Cycle Kinetics with a Fluorescent Ubiquitination-Based Cell Cycle Indicator (Fucci)

Conference Activities & Talks 【 display / non-display

  1. Katarzyna A. Inoue, Kazuki Takahashi, Sakakitani Shintaro, Daizo Koinuma, Akinari Sugauchi, Maki Saito, Atsushi Kaida, Yasuhiro Yoshimatsu, Toshihiro Uchihashi, Masahiko Miura, Kohei Miyazono, Tetsuro Watabe. Activation of epithelial-mesenchymal transition program in oral cancer cells under TGF-β-induced cell cycle arrest. TGF-β Superfamily Conference: Signaling in Development and Disease (FASEB) 2021.07.20

  2. Yuji Kabasawa, Kanade Ito, Shiori Tokura, Itsuki Takazawa, Ruri Komiya, Hiroyuki Harada, Hitomi Nojima, Masahiko Miura, Ryoichi Yoshimura. Clinical Investigation of Episil Oral Solution for Oral Mucositis during Radiochemical Treatment for Head and Neck Cancer. The 1st Annual Meeting of the International Society of Oral Care 2021.04.18 東京

  3. Kazuki Takahashi, Katarzyna A. Inoue, Yasuhiro Yoshimatsu, Atsushi Kaida, Kei Takahashi, Shimpei Kubota, Akinari Sugauchi, Toshihiro Uchihashi, Susumu Tanaka, Mikihiko Kogo, Masahiko Miura, Kohei Miyazono and Tetsuro Watabe. Regulatory role of transforming growth factor-β signals in the migration and cell cycle of oral squamous carcinoma cells. Keystone Symposia; Cancer Metastasis: The role of metabolism, immunity and microenvironment 2019.03.17 Florence, Italy

  4. Kazuki Takahashi, Katarzyna A. Inoue, Yasuhiro Yoshimatsu, Atsushi Kaida, Kei Takahashi, Shimpei Kubota, Akinari Sugauchi, Toshihiro Uchihashi, Susumu Tanaka, Mikihiko Kogo, Masahiko Miura, Kohei Miyazono and Tetsuro Watabe. TGF-β-induced cell cycle arrest is associated with increased migration and metastasis of oral squamous carcinoma cells. AACR-JCA Joint Conference 2019.02.09 Maui, USA

  5. Masahiko Miura. Hypoxia: a potential target in radiotherapy for H&N cancer and its perspective. ESTRO meets ASIA 2018.12.07 Singapore

  6. Atsushi Kaida, Yusuke Onozato, Masahiko Miura. Determining radiosensitivity of quiescent and proliferating tumor cells irradiated under different tumor microenvironments. 33th International Symposium of Radiation Biology Center, Kyoto University 2017.12.05 Kyoto

  7. Nisha Gowri Manila, Atsushi Kaida, Masahiko Miura. Insulin-like growth factor I receptor (IGF-IR) regulates radiation-induced G2/M checkpoint by controlling Chk1 localization in HeLa cells. TMDU Intractable Disease(Cancer) Unit Workshops for Young Researchers 2017.11.06 Tokyo

  8. Masahiko Miura. Redistribution revisited by visualizing cell cycle. 1st International Symposium on Radiation Therapeutics and Biology 2017.11.01 Shenzhen, China

  9. Katarzyna A. Inoue, Kazuki Takahashi, Takumi Matsuda, Yasuhiro Yoshimatsu, Atsushi Kaida, Masahiko Miura, Tetsuro Watabe. Cell cycle arrest in oral squamous carcinoma cells undergoing TGF-β-induced epithelial to mesenchymal transition. FASEB Conference 2017.07.09 Lisbon, Portugal

  10. Masahiko Miura. Oral Cancer and brachytherapy. The 39th Annual Scientific Conference on Dental Research 2017.04.04 Ho Chi Minh City, Vietnam

  11. Nisha Gowri Manila, Atsushi Kaida, Masahiko Miura. IGF-IR, but not EGFR, regulates DNA damage response (DDR) in HeLa cells following irradiation. ESMO Asia 2016 Congress 2016.12.17 Singapore

  12. Masahiko Miura. Cell cycle kinetics and radiosensitivity. The 29th Annual Meeting of JASTRO 2016.11.27 Kyoto city

  13. Yusuke Onozato, Atsushi Kaida, Hiroyuki Harada, Masahiko Miura. Radiosenstivity of proliferating or quiescent human tongue carcinoma cells grown in multicellular spheroids. The 61th congress of the Japanese Society of Oral and Maxillofacial Surgeons 2016.11.25 Chiba city

  14. Watanabe H, Ozaki K, Miura M, Yoshimura R, Sumi Y, Kurabayashi T.. Estimation of whole body radiation exposure induced by oral cancer brachytherapy using Monte Carlo simulation. The 11th Asian Congress of Oral and Maxillofacial Radiology 2016.11.12 Chiang Mai, Thailand

  15. Nisha Gowri Manila, Atsushi Kaida, Masahiko Miura. Effect of IGF-IR-inhibition on the radiation –induced cell kinetics and DNA repair. 80th Anual Meeting of the Stomatological Society 2015.12.26 Tokyo

  16. Nisha Gowri Manila, Atsushi Kaida, Masahiko Miura. IGF-1 receptor influences radeation-indeced G2 arrest in HeLa cells expressing fluorescent ubiquitination-based cell cycle indicator (Fucci). ISAJ 6th Symposium on Recent Advances and Technology 2015.12.04 Tokyo

  17. Taito Asahina, Atsushi Kaida, Keisuke Sasai, Ryoichi Yoshimura, Masahiko Miura. Temporo-spatial cell cycle kinetics in HeLa cells by Ir-192 HDR-RALS. The 28th Annual Meeting of the Japanese Society for Radiation Oncology 2015.11.20 Maebashi

  18. Masahiko Miura , Atsushi Kaida. Radiobiology for stereotactic radiotherapy. The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Workshop 2015.11.19 Maebashi

  19. Kohei Okuyama, Atsushi Kaida, Yoshiki Hayashi, Yoshio Hayashi, Kiyoshi Harada, Masahiko Miura. A novel type of anti-microtubule agent, KPU-300, is a potent radiosensitizer through synchronization of the cell cycle in M-phase. 22nd International Conference on Oral and Maxillofacial Surgery 2015.10.27 Melbourne, Australia

  20. Nisha Gowri Manila, Atsushi Kaida, Masahiko Miura. Inhibition of IGF-IR retards release from radiation-indeced G2 arrest. TMDU Student Symposium 2015, 7th TMDU International Symposium Program 2015.08.29 Tokyo

  21. Masahiko Miura. Basics of Radiation Biology with a Focus on 4Rs. 12th International Stereotactic Radiosurgery Society Congress 2015.06.07 Yokohama

  22. Masahiko Miura. Visualizing Cell cycle kinetics in HeLa cell in vitro and in vivo following X irradiation. 15th International Congress of Radiation Research 2015.05.29 Kyoto

  23. Atsushi Kaida, Masahiko Miura. Visualizing the effects of tumor microenviroments on cell cycle kinetics in HeLa cells following X-irradiation. 15th International Congress of Radiation Research 2015.05.28 Kyoto

  24. Kohei Okuyama, Atsushi Kaida, Kiyoshi Harada, Masaihko Miura. A novel type of anti-microtubule agent, KPU-300, is a potent radiosensitizer through synchronization of the cell dycle at M-phase. 15th International Congress of Radiation Research 2015.05.27 Kyoto

  25. Tatsuaki Goto, Atsushi Kaida, Masahiko Miura. Cell cycle kinetics in HeLa cells expressing Fucci under hypoxia and after reoxygenation. 15th International Congress of Radiation Research 2015.05.27 Kyoto

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Awards & Honors 【 display / non-display

  • Robotics Mechatronics Award,The Japan Society of Mechanical Engineers,2018.06