Division of Health Intelligence Research

28  articles.  
* There may be some overlapped articles listed due to the difference of format.

  1. Takumi Ito, Kohei Ota, Hidekazu Hishinuma, Hideyuki Shimizu: A Functional Atlas of the Tardigrade Resistome Reveals a Diverse Molecular Toolkit for Extremotolerance bioRxiv. 2025.06; ( DOI )

  2. Takumi Ito, Satoshi Ohno, Yiran Wang, Saori Uematsu, Shinya Kuroda, Hideyuki Shimizu: MetDeeCINE: Deciphering Metabolic Regulation through Deep Learning and Multi-Omics 2025.03; ( DOI )

  1. Shunsuke Kasai, Akio Shiomi, Hideyuki Shimizu, Monami Aoba, Yusuke Kinugasa, Takuya Miura, Kay Uehara, Jun Watanabe, Kazushige Kawai, Yoichi Ajioka: Risk factors and development of machine learning diagnostic models for lateral lymph node metastasis in rectal cancer: multicentre study. BJS Open. 2024.07; 8 (4): ( PubMed , DOI )

  2. Tsunaki Higa, Keiichi I Nakayama: Cell cycle heterogeneity and plasticity of colorectal cancer stem cells. Cancer Sci. 2024.05; 115 (5): 1370-1377. ( PubMed , DOI )

  1. Kodama M, Toyokawa G, (20名省略), Bamba T, Shimizu H, Yoshizumi T, Nakayama KI: Modulation of host glutamine anabolism enhances the sensitivity of small cell lung cancer to chemotherapy Cell Reports. 2023.08; 42 (8): 112899.

  2. Fujinuma S, Nakatsumi H, Shimizu H, Sugiyama S, Harada A, Goya T, Tanaka M, Kohjima M, Takahashi M, Izumi Y, Yagi M, Kang D, Kaneko M, Shigeta M, Bamba T, Ohkawa Y, Nakayama KI: FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation Cell Reports. 2023.05; 42 (5): 112530. ( DOI )

  3. Takeru Oka, Tsunaki Higa, Osamu Sugahara, Daisuke Koga, Shogo Nakayama, Keiichi I Nakayama: Ablation of p57+ Quiescent Cancer Stem Cells Suppresses Recurrence after Chemotherapy of Intestinal Tumors. Cancer Res. 2023.05; 83 (9): 1393-1409. ( PubMed , DOI )

  4. Hozumi H, Shimizu H: Bayesian network enables interpretable and state-of-the-art prediction of immunotherapy responses in cancer patients PNAS Nexus. 2023.04; 2 (5): pgad133. ( PubMed , DOI )

  1. Shimizu H, Kodama M, Matsumoto M, Orba Y, Sasaki Y, Sato A, Sawa H, Nakayama KI: LIGHTHOUSE illuminates therapeutics for a variety of diseases including COVID-19 iScience. 2022.10; 25 (11): 105314. ( PubMed , DOI )

  2. Habara M, Sato Y, Goshima T, Sakurai M, Imai H, Shimizu H, Katayama Y, Hanaki S, Masaki T, Morimoto M, Nishikawa S, Toyama T, Shimada M: FKBP52 and FKBP51 Differentially Regulate the Stability of Estrogen Receptor in Breast Cancer Proc Natl Acad Sci U S A. 2022.04; 119 (15): e2110256119. ( PubMed , DOI )

  3. Tsunaki Higa, Yasutaka Okita, Akinobu Matsumoto, Shogo Nakayama, Takeru Oka, Osamu Sugahara, Daisuke Koga, Shoichiro Takeishi, Hirokazu Nakatsumi, Naoki Hosen, Sylvie Robine, Makoto M Taketo, Toshiro Sato, Keiichi I Nakayama: Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium. Nat Commun. 2022.03; 13 (1): 1500. ( PubMed , DOI )

  4. Mise S, Matsumoto A, Shimada K, Hosaka T, Takahashi M, Ichihara K, Shimizu H, Shiraishi C, Saito D, Suyama M, Yasuda T, Ide T, Izumi Y, Bamba T, Kimura-Someya T, Shirouzu M, Miyata H, Ikawa M, Nakayama KI: Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis. Nature communications. 2022.02; 13 (1): 1071. ( PubMed , DOI )

  1. Ichihara K, Matsumoto A, Nishida H, Kito Y, Shimizu H, Shichino Y, Iwasaki S, Imami K, Ishihama Y, Nakayama KI: Combinatorial analysis of translation dynamics reveals eIF2 dependence of translation initiation at near-cognate codons Nucleic Acids Research. 2021.07; 49 (13): 7298-7317. ( PubMed , DOI )

  2. Shimizu H, Nakayama KI: A universal molecular prognostic score for gastrointestinal tumors. NPJ genomic medicine. 2021.02; 6 (1): 6. ( PubMed , DOI )

  1. Onoyama I, Nakayama S, Shimizu H, Nakayama KI: Loss of Fbxw7 Impairs Development of and Induces Heterogeneous Tumor Formation in the Mouse Mammary Gland. Cancer research. 2020.12; 80 (24): 5515-5530. ( PubMed , DOI )

  2. Yamauchi Y, Nita A, Nishiyama M, Muto Y, Shimizu H, Nakatsumi H, Nakayama KI.: Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development Genes Cells. 2020.06; 25 (6): 427-438. ( PubMed , DOI )

  3. Shimizu H, Nakayama KI: Artificial intelligence in oncology. Cancer science. 2020.05; 111 (5): 1452-1460. ( PubMed , DOI )

  4. Oshikawa K, Matsumoto M, Kodama M, Shimizu H, Nakayama KI: A fail-safe system to prevent oncogenesis by senescence is targeted by SV40 small T antigen. Oncogene. 2020.03; 39 (10): 2170-2186. ( PubMed , DOI )

  5. Kodama M, Oshikawa K, Shimizu H, Yoshioka S, Takahashi M, Izumi Y, Bamba T, Tateishi C, Tomonaga T, Matsumoto M, Nakayama KI: A shift in glutamine nitrogen metabolism contributes to malignant progression of cancer Nature Communications. 2020.03; 11 (1320):

  1. Shimizu H, Nakayama KI: A 23 gene-based molecular prognostic score precisely predicts overall survival of breast cancer patients. EBioMedicine. 2019.08; 46 150-159. ( PubMed , DOI )

  2. Muto Y, Moroishi T, Ichihara K, Nishiyama M, Shimizu H, Eguchi H, Moriya K, Koike K, Mimori K, Mori M, Katayama Y, Nakayama KI: Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis Journal of Experimental Medicine. 2019.04; 216 (4): 950-965. ( PubMed , DOI )

  3. Shimizu H, Takeishi S, Nakatsumi H, Nakayama KI: Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells JCI Insight. 2019.02; 4 (4): 125138.

  4. Shimizu H, Takeishi S, Nakatsumi H, Nakayama KI: Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells. JCI insight. 2019.02; 4 (4): ( PubMed , DOI )

  1. Yuriko Saiki, Yuki Yoshino, Hiroko Fujimura, Tatsuya Manabe, Yuki Kudo, Miki Shimada, Nariyasu Mano, Tomohiro Nakano, Yoonha Lee, Shinjiro Shimizu, Shinya Oba, Sho Fujiwara, Hideyuki Shimizu, Na Chen, Zhaleh Kashkouli Nezhad, Guo Jin, Shinichi Fukushige, Makoto Sunamura, Masaharu Ishida, Fuyuhiko Motoi, Shinichi Egawa, Michiaki Unno, Akira Horii: DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells Biochem Biophys Res Commun.. 2012.04; 421 (1): 98-104. ( PubMed , DOI )

  1. Shimizu H, Horii A, Sunamura M, Motoi F, Egawa S, Unno M, Fukushige S: Identification of epigenetically silenced genes in human pancreatic cancer by a novel method "microarray coupled with methyl-CpG targeted transcriptional activation" (MeTA-array) Biochem Biophys Res Commun.. 2011.07; 411 (1): 162-167. ( PubMed , DOI )

  1. Tomoya Sakuma, Yuki Otani, Hideyuki Shimizu: High-Resolution Mapping of the Human E3-Substrate Interactome using Ubicon Uncovers Network Architecture and Cancer Vulnerabilities bioRxiv. 2025.04; ( DOI )

  2. Yuki Otani, Daisuke Koga, Yasunari Wakizaka, Hideyuki Shimizu: BaCNet: Deep Learning Accelerates Novel Antibiotic Discovery Against Resistant Pathogens bioRxiv. 2025.03; ( DOI )

  3. Yuki Otani, Daisuke Koga, Yasunari Wakizaka, Hideyuki Shimizu: AMP-Atlas: Comprehensive Atlas of Antimicrobial Peptides to Combat Multidrug-resistant Bacteria bioRxiv. 2025.03; ( DOI )

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