Cellular Dynamics

113  articles.  
* There may be some overlapped articles listed due to the difference of format.

  1. Hiroki Hirao, Ahmad Adawy, Yukio Fujiwara, Daiki Yoshii, Cheng Pan, Lianbo Li, Hiromu Yano, Yoshihiko Kondo, Masaki Honda, Jia Han, Yao Liu, Sohsuke Yamada, Eiso Hiyama, Paweenapon Chunthaboon, Yasuhisa Sakamoto, Toshiro Moroishi, Masahiro Yamamoto, Taizo Hibi, Yoshihiro Komohara: Aberrant SOX9 expression mediated by protumour macrophages predicts poorer clinical outcomes in hepatoblastoma. J Pathol. 2026.08; ( PubMed , DOI )

  2. Horino T, Horiguchi H, Torigoe D, Yumoto S, Kadomatsu T, Harada K, Sato M, Moroishi T, Iwatsuki M, Oike Y: Caloric restriction suppresses colorectal tumors and melanoma through CD8 T cells in aged mice. Cell reports. 2026.08; 45 (8): 117844. ( PubMed , DOI )

  3. Ogawa, M; Fujisawa, T; Takenaka, S; Yano, M; Kuroda, M; Taniguchi, D; Wang, ZW; Hiratsuka, T; Kanai, A; Suzuki, Y; Sato, S; Miyagi, Y; Takano, A; Daigo, Y; Nita, A; Moroishi, T; Naguro, I; Ichijo, H: FGF21 suppresses hepatocellular carcinoma by driving competitive cell-cell interactions CELL REPORTS. 2026.06; 45 (6): 117410. ( PubMed , DOI )

  4. Maeda, A; Moroishi, T: Protocol to assess intracellular labile iron and oxygen at single-cell resolution using a genetically encoded ratiometric reporter STAR PROTOCOLS. 2026.06; 7 (2): 104561. ( PubMed , DOI )

  5. Ryoko Kusaba, Keishi Miyata, Tsuyoshi Kadomatsu, Michio Sato, Yoshihiro Ujihara, Yuya Kinoshita, Daisuke Torigoe, Momoka Chuman, Yui Sakai, Haruki Horiguchi, Taichi Sugizaki, Jun Morinaga, Keiichi I. Nakayama, Toshiro Moroishi, Tomohiko Wakayama, Kimi Araki, Kimitoshi Nakamura, Yuichi Oike: Cardiomyocyte-specific Fbxl5 deficiency promotes iron overload-driven hypercontractility and late-onset pathological hypertrophy in mice Journal of Cardiology. 2026.05; 88 (3): 180-190. ( PubMed , DOI )

  6. Paweenapon Chunthaboon, Mohamed Fathi Saleh, Yasuhisa Sakamoto, Toshiro Moroishi: YAP Induces Ferroptosis Vulnerability in Breast Cancer via GCH1 suppression Biochemical and Biophysical Research Communications. 2026.05; 823 153969. ( PubMed , DOI )

  7. Saleh Mohamed Fathi, Nita Akihiro, Ohta Yudai, Kobayashi Aya, Li Hao, Sakamoto Yasuhisa, Moroishi Toshiro: Hippo Pathway Drives Durable Non-Cell-Autonomous Ferroptosis Resistance in Lung Cancer(タイトル和訳中) Cancer Science. 2026.03; 117 (3): 683-694. ( ichushi )

  8. Nduru, D; Ohta, Y; Nita, A; Niimura, M; Ngurari, S; Moroishi, T: A YAP/TAZ-CDC6 Axis Initiates and Maintains Malignant Transformation CANCER SCIENCE. 2026.02; 117 (2): 353-363. ( PubMed , DOI )

  9. Kurata, H; Ngurari, S; Nita, A; Sakamoto, Y; Nduru, D; Moroishi, T: A kinase inhibitor screen identifies GSK690693 as a Hippo pathway inhibitor targeting ER-positive breast cancer JOURNAL OF BIOCHEMISTRY. 2026.01; 179 (4): 283-292. ( PubMed , DOI )

  10. Li, H; Moroishi, T; Yao, I; Li, SR: Auranofin resensitizes ferroptosis-resistant lung cancer cells to ferroptosis inducers CANCER SCIENCE. 2026.01; 117 1054.

  11. Harada, N; Niimura, M; Sakamoto, Y; Nita, A; Shimoda, M; Wada, S; Murata, K; Wakao, M; Kamba, T; Shinchi, H; Moroishi, T: Peptide modulation overrides glycan synergy in gold nanoparticle-based vaccines for cancer immunotherapy CANCER SCIENCE. 2026.01; 117 628.

  1. Saleh, MF; Nita, A; Ohta, Y; Kobayashi, A; Li, H; Sakamoto, Y; Moroishi, T: Hippo Pathway Drives Durable Non-Cell-Autonomous Ferroptosis Resistance in Lung Cancer CANCER SCIENCE. 2025.12; 117 (3): 683-694. ( PubMed , DOI )

  2. Maeda, A; Nita, A; Moroishi, T: Glutamine metabolism drives B cell proliferation under elevated atmospheric pressure BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2025.11; 790 152892. ( PubMed , DOI )

  3. Harada, N; Niimura, M; Sakamoto, Y; Nita, A; Shimoda, M; Wada, S; Murata, K; Wakao, M; Kamba, T; Shinchi, H; Moroishi, T: Peptide Modulation Overrides Glycan Synergy in Gold Nanoparticle-Based Vaccines for Cancer Immunotherapy CANCER MEDICINE. 2025.10; 14 (19): e71286. ( PubMed , DOI )

  4. Saisai Liu, Yohei Kanamori, Yudai Ohta, Shuran Li, Yanliang Liu, Hao Li, Mohamed Fathi Saleh, Akihiro Nita, Keiichi I. Nakayama, Toshiro Moroishi: Iron overload in CD11c+ myeloid cells exacerbates acetaminophen hepatotoxicity Communications Biology. 2025.10; 8 (1): 1488. ( PubMed , DOI )

  5. Liu Yanliang, Liu Saisai, Sakamoto Yasuhisa, Chunthaboon Paweenapon, Thinyakul Chanida, Mori Ryunosuke, Li Shuran, Watanabe-Nakayama Takahiro, Omata Seiji, Morita Yasuyuki, Moroishi Toshiro: LATS1/2-Integrin Axis Confers Tumor-Generated Forces That Activate Neighboring Fibroblasts(タイトル和訳中) Cancer Science. 2025.09; 116 (9): 2486-2498. ( ichushi )

  6. Yohei Kanamori, Akihiro Nita, Keiichi I. Nakayama, Daisuke Kurotaki, Kenichi Harada, Toshiro Moroishi: Hepatocyte iron suppresses liver fibrosis via fibrolytic neutrophil recruitment in cholestasis JHEP Reports. 2025.09; 7 (12): 101590. ( PubMed , DOI )

  7. Li, H; Li, SR; Kanamori, Y; Liu, SS; Moroishi, T: Auranofin resensitizes ferroptosis-resistant lung cancer cells to ferroptosis inducers BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2025.07; 770 151992. ( PubMed , DOI )

  8. Li, H; Kanamori, Y; Nita, A; Maeda, A; Zhang, TL; Kikuchi, K; Yamada, H; Toyomoto, T; Saleh, MF; Niimura, M; Hinokuma, H; Shimoda, M; Ikeda, K; Suzuki, M; Komohara, Y; Kurotaki, D; Sawa, T; Moroishi, T: Hippo pathway controls biopterin metabolism to shield adjacent cells from ferroptosis in lung cancer EMBO REPORTS. 2025.07; 26 (16): 4124-4152. ( PubMed , DOI )

  9. Kodai Nakamura, Huascar-Pedro Ortuste-Quiroga, Naoki Horii, Shin Fujimaki, Toshiro Moroishi, Keiichi I. Nakayama, Shinjiro Hino, Yoshihiko Saito, Ichizo Nishino, Yusuke Ono: Iron supplementation alleviates pathologies in a mouse model of facioscapulohumeral muscular dystrophy Journal of Clinical Investigation. 2025.07; 135 (17): ( PubMed , DOI )

  10. Liu, YL; Liu, SS; Sakamoto, Y; Chunthaboon, P; Thinyakul, C; Mori, R; Li, SR; Watanabe-Nakayama, T; Omata, S; Morita, Y; Moroishi, T: LATS1/2-Integrin Axis Confers Tumor-Generated Forces That Activate Neighboring Fibroblasts CANCER SCIENCE. 2025.07; 116 (9): 2486-2498. ( PubMed , DOI )

  11. Matsumoto, T; Nita, A; Kanamori, Y; Maeda, A; Nita, T; Yasuda-Yoshihara, N; Mima, K; Okabe, H; Imai, K; Hayashi, H; Matsuoka, Y; Nagaoka, K; Nakayama, KI; Sugiura, Y; Tanaka, Y; Baba, H; Moroishi, T: Integrated hepatic ferroptosis gene signature dictates pathogenic features of ferroptosis HEPATOLOGY COMMUNICATIONS. 2025.06; 9 (6): ( PubMed , DOI )

  12. Shoko Sashiyama, Tadashi Nakagawa, Makiko Nakagawa, Masaki Hosogane, Yasuaki Watanabe, Honoka Ashitomi, Kazusa Yamane, Norihiro Shibuya, Toshiro Moroishi, Keiko Nakayama, Toru Hosoi: KBG syndrome-associated protein ANKRD11 regulates SETD5 expression to modulate rRNA levels and translation iScience. 2025.05; 28 (6): 112699. ( PubMed , DOI )

  13. Pawaret Panyajai, Natsima Viriyaadhammaa, Sawitree Chiampanichayakul, Yasuhisa Sakamoto, Siriporn Okonogi, Toshiro Moroishi, Songyot Anuchapreeda: Anticancer and cancer preventive activities of shogaol and curcumin from Zingiberaceae family plants in KG-1a leukemic stem cells BMC Complementary Medicine and Therapies. 2025.02; 25 (1): ( PubMed , DOI )

  14. Tatsuya Morishima, Md Fakruddin, Yohei Kanamori, Takeshi Masuda, Akiko Ogawa, Yuxin Wang, Vivien A C Schoonenberg, Falk Butter, Yuichiro Arima, Takaaki Akaike, Toshiro Moroishi, Kazuhito Tomizawa, Toshio Suda, Fan-Yan Wei, Hitoshi Takizawa: Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis. Science advances. 2025.02; 11 (8): eadu3011. ( PubMed , DOI )

  15. Moroishi, T; Thinyakul, C; Liu, YL; Morita, Y: The Hippo pathway constructs an immunosuppressive tumor microenvironment through mechanical signaling CANCER SCIENCE. 2025.01; 116 1441.

  1. Yumoto Shinsei, Horiguchi Haruki, Kadomatsu Tsuyoshi, Horino Taichi, Sato Michio, Terada Kazutoyo, Miyata Keishi, Moroishi Toshiro, Baba Hideo, Oike Yuichi: Host ANGPTL2 establishes an immunosuppressive tumor microenvironment and resistance to immune checkpoint therapy(タイトル和訳中) Cancer Science. 2024.12; 115 (12): 3846-3858. ( ichushi )

  2. Yasuhisa Sakamoto, Akiyoshi Uezu, Koji Kikuchi, Jangmi Kang, Eiko Fujii, Toshiro Moroishi, Shiro Suetsugu, Hiroyuki Nakanishi: The Nedd4L ubiquitin ligase is activated by FCHO2-generated membrane curvature The EMBO Journal. 2024.10; 43 (22): 5747-5779. ( PubMed , DOI )

  3. Chanida Thinyakul, Yasuhisa Sakamoto, Mayuko Shimoda, Yanliang Liu, Suyanee Thongcho, Omnia Reda, Akihiro Nita, Romgase Sakamula, Somponnat Sampattavanich, Ayato Maeda, Paweenapon Chunthaboon, David Nduru, Mayumi Niimura, Yohei Kanamori, Peti Thuwaji, Keiichi I. Nakayama, Kun-Liang Guan, Yorifumi Satou, Chanitra Thuwaji, Toshiro Moroishi: Hippo pathway in cancer cells induces NCAM1+αSMA+ fibroblasts to modulate tumor microenvironment Communications Biology. 2024.10; 7 (1): 1343. ( PubMed , DOI )

  4. Tomoya Yamashita, Haruki Horiguchi, Tsuyoshi Kadomatsu, Michio Sato, Toshiro Moroishi, Yuichi Oike: Immunotherapy-induced reprogramming of cancer-associated fibroblasts can promote tumor progression. Genes to cells : devoted to molecular & cellular mechanisms. 2024.10; 29 (12): 1275-1283. ( PubMed , DOI )

  5. Shinsei Yumoto, Haruki Horiguchi, Tsuyoshi Kadomatsu, Taichi Horino, Michio Sato, Kazutoyo Terada, Keishi Miyata, Toshiro Moroishi, Hideo Baba, Yuichi Oike: Host ANGPTL2 establishes an immunosuppressive tumor microenvironment and resistance to immune checkpoint therapy. Cancer science. 2024.09; 115 (12): 3846-3858. ( PubMed , DOI )

  6. Hao Li, Yohei Kanamori, Toshiro Moroishi: Cell attachment defines sensitivity to cold stress via the Hippo pathway Biochemical and Biophysical Research Communications. 2024.07; 730 150373. ( PubMed , DOI )

  7. Koki Murata, Kai Harayama, Mayuko Shimoda, Mayumi Niimura, Masahiro Wakao, Yasuo Suda, Toshiro Moroishi, Hiroyuki Shinchi: Improvement of the Nuclease Resistance and Immunostimulatory Activity of CpG Oligodeoxynucleotides by Conjugation to Sugar-Immobilized Gold Nanoparticles Bioconjugate Chemistry. 2024.05; 35 (6): 804-815. ( PubMed , DOI )

  8. Nita Akihiro, Moroishi Toshiro: 細胞間情報伝達におけるHippo経路　発生と再生において判明しつつある役割(Hippo pathway in cell-cell communication: emerging roles in development and regeneration) Inflammation and Regeneration. 2024.04; 44 s41232-024. ( ichushi )

  9. Akihiro Nita, Toshiro Moroishi: Hippo pathway in cell–cell communication: emerging roles in development and regeneration Inflammation and Regeneration. 2024.04; 44 (1): ( PubMed , DOI )

  10. Haruki Horiguchi, Tsuyoshi Kadomatsu, Tomoya Yamashita, Shinsei Yumoto, Taichi Horino, Michio Sato, Kazutoyo Terada, Keishi Miyata, Yuki Ichigozaki, Toshihiro Kimura, Satoshi Fukushima, Toshiro Moroishi, Yuichi Oike: Tumor stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy. Cancer Gene Therapy. 2024.03; 31 (6): 933-940. ( PubMed , DOI )

  1. Hinokuma Hironori, Kanamori Yohei, Ikeda Koei, Hao Li, Maruno Masataka, Yamane Taishi, Maeda Ayato, Nita Akihiro, Shimoda Mayuko, Niimura Mayumi, Takeshima Yuki, Li Shuran, Suzuki Makoto, Moroishi Toshiro: 肺癌細胞増殖における第一鉄と第二鉄で異なる機能(Distinct functions between ferrous and ferric iron in lung cancer cell growth) Cancer Science. 2023.11; 114 (11): 4355-4364. ( ichushi )

  2. Hironori Hinokuma, Yohei Kanamori, Koei Ikeda, Li Hao, Masataka Maruno, Taishi Yamane, Ayato Maeda, Akihiro Nita, Mayuko Shimoda, Mayumi Niimura, Yuki Takeshima, Shuran Li, Makoto Suzuki, Toshiro Moroishi: Distinct functions between ferrous and ferric iron in lung cancer cell growth. Cancer science. 2023.09; 114 (11): 4355-4364. ( PubMed , DOI )

  3. Maruno, M; Kanamori, YH; Matsumoto, T; Shiraishi, Y; Takematsu, T; Miyata, T; Mima, K; Nakagawa, S; Nitta, H; Hayashi, H; Moroishi, T; Baba, H: Intracellular ferritin expression levels regulate growth and resistance to ferroptosis in pancreatic cancer cell lines CANCER RESEARCH. 2023.04; 83 (7): ( DOI )

  1. Bu Luke, Yonemura Atsuko, Yasuda-Yoshihara Noriko, Uchihara Tomoyuki, Ismagulov Galym, Takasugi Sanae, Yasuda Tadahito, Okamoto Yuya, Kitamura Fumimasa, Akiyama Takahiko, Arima Kota, Itoyama Rumi, Zhang Jun, Fu Lingfeng, Hu Xichen, Wei Feng, Arima Yuichiro, Moroishi Toshiro, Nishiyama Koichi, Sheng Guojun, Mukunoki Toshifumi, Otani Jun, Baba Hideo, Ishimoto Takatsugu: 腫瘍微小環境における15-PGDHの枯渇は膵臓癌における線維性腫瘍形成と血管新生を促進する(Tumor microenvironmental 15-PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer) Cancer Science. 2022.10; 113 (10): 3579-3592. ( ichushi )

  2. Taishi Yamane, Yohei Kanamori, Hiroshi Sawayama, Hiromu Yano, Akihiro Nita, Yudai Ohta, Hironori Hinokuma, Ayato Maeda, Akiko Iwai, Takashi Matsumoto, Mayuko Shimoda, Mayumi Niimura, Shingo Usuki, Noriko Yasuda-Yoshihara, Masato Niwa, Yoshifumi Baba, Takatsugu Ishimoto, Yoshihiro Komohara, Tomohiro Sawa, Tasuku Hirayama, Hideo Baba, Toshiro Moroishi: Iron accelerates Fusobacterium nucleatum-induced CCL8 expression in macrophages and is associated with colorectal cancer progression JCI Insight. 2022.09; 7 (21): ( PubMed , DOI )

  3. Haruki Horiguchi, Tsuyoshi Kadomatsu, Shinsei Yumoto, Takeshi Masuda, Keishi Miyata, Shuji Yamamura, Michio Sato, Jun Morinaga, Sumio Ohtsuki, Hideo Baba, Toshiro Moroishi, Yuichi Oike: Tumor cell-derived ANGPTL2 promotes β-catenin-driven intestinal tumorigenesis Oncogene. 2022.07; 41 (33): 4028-4041. ( PubMed , DOI )

  4. Luke Bu, Atsuko Yonemura, N. Yasuda‐Yoshihara, Tomoyuki Uchihara, Galym Ismagulov, Sanae Takasugi, Tadahito Yasuda, Yuya Okamoto, Fumimasa Kitamura, Takahiko Akiyama, Kota Arima, Rumi Itoyama, Jun Zhang, Lingfeng Fu, Xichen Hu, Feng Wei, Yuichiro Arima, Toshiro Moroishi, Koichi Nishiyama, Guojun Sheng, Toshifumi Mukunoki, Jun Otani, Hideo Baba, Takatsugu Ishimoto: Tumor microenvironmental 15‐PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer Cancer Science. 2022.07; 113 (10): 3579-3592. ( PubMed , DOI )

  5. Light-Controllable Binary Switch Activation of CAR T Cells 2022.06; 17 (12): ( DOI )

  6. Hiroyuki Shinchi, Fumikazu Komaki, Masaharu Yuki, Haruka Ohara, Naohiro Hayakawa, Masahiro Wakao, Howard B. Cottam, Tomoko Hayashi, Dennis A. Carson, Toshiro Moroishi, Yasuo Suda: Glyco-Nanoadjuvants: Impact of Linker Length for Conjugating a Synthetic Small-Molecule TLR7 Ligand to Glyco-Nanoparticles on Immunostimulatory Effects ACS Chemical Biology. 2022.03; 17 (4): 957-968. ( PubMed , DOI )

  7. Yamane, T; Sawayama, H; Morinaga, T; Mima, K; Iwatsuki, M; Baba, Y; Ishimoto, T; Iwagami, S; Miyamoto, Y; Yoshida, N; Moroishi, T; Baba, H: The relationship between Fusobacterium nucleatum and iron in colorectal cancer CANCER SCIENCE. 2022.02; 113 421.

  8. Daichi Nomoto, Yoshifumi Baba, Yang Liu, Hiroyasu Tsutsuki, Kazuo Okadome, Kazuto Harada, Takatsugu Ishimoto, Masaaki Iwatsuki, Shiro Iwagami, Yuji Miyamoto, Naoya Yoshida, Masayuki Watanabe, Toshiro Moroishi, Yoshihiro Komohara, Tomohiro Sawa, Hideo Baba: Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression via the NOD1/RIPK2/NF-κB pathway Cancer Letters. 2022.01; 530 59-67. ( PubMed , DOI )

  9. Le Yu, Dan Zhou, Guiming Zhang, Zhonglu Ren, Xin Luo, Peng Liu, Steven W. Plouffe, Zhipeng Meng, Toshiro Moroishi, Yilei Li, Yiyue Zhang, Joan Heller Brown, Shuwen Liu, Kun‐Liang Guan: Co‐occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence Molecular Oncology. 2022; 16 (3): 607-629. ( PubMed , DOI )

  1. Toshiro Moroishi: ANXious for YAP Nature Chemical Biology. 2021.07; 17 (7): 750-751. ( PubMed , DOI )

  2. Hiroyuki Shinchi, Masaharu Yuki, Takayoshi Yamauchi, Mayumi Niimura, Masahiro Wakao, Howard B. Cottam, Tomoko Hayashi, Dennis A. Carson, Toshiro Moroishi, Yasuo Suda: Glyco-Nanoadjuvants: Sugar Structures on Carriers of a Small Molecule TLR7 Ligand Affect Their Immunostimulatory Activities ACS Applied Bio Materials. 2021.03; 4 (3): 2732-2741. ( PubMed , DOI )

  3. Luo, M; Meng, ZP; Moroishi, T; Lin, KC; Shen, GB; Mo, F; Shao, B; Wei, XW; Zhang, P; Wei, YQ; Guan, KL: Heat stress activates YAP/TAZ to induce the heat shock transcriptome (vol 22, pg 1447, 2020) NATURE CELL BIOLOGY. 2021.02; 23 (2): 209. ( PubMed , DOI )

  4. Yamauchi Takayoshi, Moroishi Toshiro: 腫瘍免疫における腫瘍由来細胞外小胞の陰と陽(【Medical chemistry of extracellular vesicles】The Yin and Yang of tumour-derived extracellular vesicles in tumour immunity) The Journal of Biochemistry. 2021.02; 169 (2): 155-161. ( ichushi )

  5. Takayoshi Yamauchi, Toshiro Moroishi: The Yin and Yang of tumour-derived extracellular vesicles in tumour immunity The Journal of Biochemistry. 2021; 169 (2): 155-161. ( PubMed , DOI )

  1. Min Luo, Zhipeng Meng, Toshiro Moroishi, Kimberly C. Lin, Guobo Shen, Fei Mo, Bin Shao, Xiawei Wei, Ping Zhang, Yuquan Wei, Kun-Liang Guan: Heat stress activates YAP/TAZ to induce the heat shock transcriptome Nature Cell Biology. 2020.12; 22 (12): 1447-1459. ( PubMed , DOI )

  2. Haruki Horiguchi, Tsuyoshi Kadomatsu, Keishi Miyata, Kazutoyo Terada, Michio Sato, Daisuke Torigoe, Jun Morinaga, Toshiro Moroishi, Yuichi Oike: Stroma-derived ANGPTL2 establishes an anti-tumor microenvironment during intestinal tumorigenesis Oncogene. 2020.10; 40 (1): 55-67. ( PubMed , DOI )

  3. Shimoda Mayuko, Moroishi Toshiro: Hippo pathwayとノンコーディングRNAとの新たなリンク(The Emerging Link between the Hippo Pathway and Non-coding RNA) Biological & Pharmaceutical Bulletin. 2020.01; 43 (1): 1-10. ( ichushi )

  1. Rosenthal, CK; Moroishi, T: Spotlight on early-career researchers: an interview with Toshiro Moroishi COMMUNICATIONS BIOLOGY. 2019.12; 2 (1): ( DOI )

  2. Haruki Horiguchi, Tsuyoshi Kadomatsu, Ryoma Kurahashi, Chiaki Hara, Keishi Miyata, Masaya Baba, Hironobu Osumi, Kazutoyo Terada, Kimi Araki, Toshiyuki Takai, Tomomi Kamba, W Marston Linehan, Toshiro Moroishi, Yuichi Oike: Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity. Genes & development. 2019.12; 33 (23-24): 1641-1656. ( PubMed , DOI )

  3. Shinchi, H, Yamaguchi, T, Moroishi, T, Yuki, M, Wakao, M, Hayashi, T, Cottam, H.B, Carson, D.A, Suda, Y: Gold nanoparticles co-immobilized with small molecule toll-like receptor 7 ligand and α-mannose as adjuvants Bioconjugate Chem.. 2019.10; 30 (11): 2811-2821. ( PubMed , DOI )

  4. Shinchi, H; Yamaguchi, T; Moroishi, T; Hayashi, T; Cottam, H; Carson, D; Wakao, M; Suda, Y: Development of toll-like receptor 7 ligand and a-mannose immobilized gold nanoparticles toward adjuvant immunotherapy ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2019.08; 258

  5. Muto Y, Moroishi T, Ichihara K, Nishiyama M, Shimizu H, Eguchi H, Moriya K, Koike K, Mimori K, Mori M, Katayama Y, Nakayama KI: Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis Journal of Experimental Medicine. 2019.04; 216 (4): 950-965. ( PubMed , DOI )

  6. Takayoshi Yamauchi, Toshiro Moroishi: Hippo Pathway in Mammalian Adaptive Immune System Cells. 2019.04; 8 (5): 398. ( PubMed , DOI )

  7. Sachin Verma, Narayana Yeddula, Yasushi Soda, Quan Zhu, Gerald Pao, James Moresco, Jolene K. Diedrich, Audrey Hong, Steve Plouffe, Toshiro Moroishi, Kun-Liang Guan, Inder M. Verma: BRCA1/BARD1-dependent ubiquitination of NF2 regulates Hippo-YAP1 signaling Proceedings of the National Academy of Sciences. 2019.04; 116 (15): 7363-7370. ( PubMed , DOI )

  8. Ei Ei Mon , Wei Fan-Yan, Ahmad Raja Norazireen Raja, Yamamoto Takahiro, Moroishi Toshiro, Tomizawa Kazuhito: sideroflexin 2によるミトコンドリアでの鉄恒常性の制御(Regulation of mitochondrial iron homeostasis by sideroflexin 2) The Journal of Physiological Sciences. 2019.03; 69 (2): 359-373. ( ichushi )

  9. Mon, E.E, Wei, F.Y, Ahmad, R.N.R, Yamamoto, T, Moroishi, T, Tomizawa, K: Regulation of mitochondrial iron homeostasis by sideroflexin 2. J. Physiol. Sci.. 2019.03; 69 (2): 359-373. ( PubMed , DOI )

  10. Systematic discovery of immune regulatory mechanisms in tumor cells 2019.02; 7 (2): ( DOI )

  1. Meng, ZP; Qiu, YJ; Lin, KC; Kumar, A; Placone, JK; Fang, C; Wang, KC; Lu, SC; Pan, M; Hong, AW; Moroishi, T; Luo, M; Plouffe, SW; Diao, YR; Ye, Z; Park, HW; Wang, XQ; Yu, FX; Chien, S; Wang, CY; Ren, B; Engler, AJ; Guan, KL: RAP2 mediates mechanoresponses of the Hippo pathway NATURE. 2018.08; 560 (7720): 655-660. ( PubMed , DOI )

  2. Daniel Martin, Maria S. Degese, Lynn Vitale-Cross, Ramiro Iglesias-Bartolome, Juan Luis Callejas Valera, Zhiyong Wang, Xiaodong Feng, Huwate Yeerna, Vachan Vadmal, Toshiro Moroishi, Rick F. Thorne, Moraima Zaida, Bradford Siegele, Sok C. Cheong, Alfredo A. Molinolo, Yardena Samuels, Pablo Tamayo, Kun Liang Guan, Scott M. Lippman, J. Guy Lyons, J. Silvio Gutkind: Assembly and activation of the Hippo signalome by FAT1 tumor suppressor Nature Communications. 2018.07; 9 (1): 2372. ( PubMed , DOI )

  3. A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing 2018.02; 359 (6377): 770-+. ( DOI )

  4. Wei-Wei Pan, Toshiro Moroishi, Ja Hyun Koo, Kun-Liang Guan: Cell type-dependent function of LATS1/2 in cancer cell growth Oncogene. 2018; 38 (14): 2595-2610. ( PubMed , DOI )

  1. Cosset, É; Ilmjärv, S; Dutoit, V; Elliott, K; von Schalscha, T; Camargo, MF; Reiss, A; Moroishi, T; Seguin, L; Gomez, G; Moo, JS; Preynat-Seauve, O; Krause, KH; Chneiweiss, H; Sarkaria, JN; Guan, KL; Dietrich, PY; Weis, SM; Mischel, PS; Cheresh, DA: Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma CANCER CELL. 2017.12; 32 (6): 856-868.e5. ( PubMed , DOI )

  2. Kimberly C. Lin, Toshiro Moroishi, Zhipeng Meng, Han-Sol Jeong, Steven W. Plouffe, Yoshitaka Sekido, Jiahuai Han, Hyun Woo Park, Kun-Liang Guan: Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation Nature Cell Biology. 2017.08; 19 (8): 996-1002. ( PubMed , DOI )

  3. Yoshiharu Muto, Masaaki Nishiyama, Akihiro Nita, Toshiro Moroishi, Keiichi I. Nakayama: Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells Nature Communications. 2017.07; 8 (1): 1-13. ( PubMed , DOI )

  4. Koji Taniguchi, Toshiro Moroishi, Petrus R. de Jong, Michal Krawczyk, Britta Moyo Grebbin, Huiyan Luo, Rui-hua Xu, Nicole Golob-Schwarzl, Caroline Schweiger, Kepeng Wang, Giuseppe Di Caro, Ying Feng, Eric R. Fearon, Eyal Raz, Lukas Kenner, Henner F. Farin, Kun-Liang Guan, Johannes Haybaeck, Christian Datz, Kang Zhang, Michael Karin: YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis Proceedings of the National Academy of Sciences. 2017.02; 114 (7): 1643-1648. ( PubMed , DOI )

  5. Takayoshi Yamauchi, Masaaki Nishiyama, Toshiro Moroishi, Atsuki Kawamura, Keiichi I. Nakayama: FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells Molecular and Cellular Biology. 2017.01; 37 (8): ( PubMed , DOI )

  1. ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production 2016.05; 11 (5): ( DOI )

  1. SPARC in tumor microenvironment induces dormancy of prostate cancer in bone 2015.08; 75 ( DOI )

  1. ABCA1, ABCG1, and ABCG4 Are Distributed to Distinct Membrane Meso-Domains and Disturb Detergent-Resistant Domains on the Plasma Membrane 2014.10; 9 (10): ( DOI )

  1. HAS2 promotes tumor progression by stimulating interaction of cancer stem-like cells with tumor associated macrophage and stromal cells through a paracrine loop of growth factors in the bone 2013.04; 73 (8): ( DOI )

  2. Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain 2013.03; 5 (3): 384-396. ( DOI )

  3. Interleukin-1β promotes brain metastasis of breast cancer by activating Notch signaling through reactive astrocytes 2013.02; 73 ( DOI )

  4. miR-7 suppresses brain metastasis of cancer stem-like cells by modulating Kruppel-like factor 4 in breast cancer 2013.02; 73 ( DOI )

  1. Hyaluronan synthase 2 promotes breast cancer bone metastasis by stimulating interaction of cancer stem-like cells with tumor-associated macrophage 2012.04; 72 ( DOI )

  2. Roles of lipogenesis in cancer stem-like cells at early stage of breast cancer 2012.04; 72 ( DOI )

  3. N-myc downstream regulated gene 1, NDRG1, modulates Wnt-β-catenin signaling and pleiotropically suppresses metastasis 2012.04; 72 ( DOI )

  4. Reactive astrocytes promote the growth of cancer stem-like cells of metastatic breast tumor by activating Notch signaling in brain 2012.04; 72 ( DOI )

  5. Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone (vol 19, pg 2641, 2011) 2012.03; 209 (3): 639. ( DOI )

  6. N-myc downstream regulated gene 1 modulates Wnt-ß-catenin signalling and pleiotropically suppresses metastasis 2012.02; 4 (2): 93-108. ( DOI )

  7. Hyaluronan Synthase HAS2 Promotes Tumor Progression in Bone by Stimulating the Interaction of Breast Cancer Stem-Like Cells with Macrophages and Stromal Cells 2012.01; 72 (2): 537-547. ( DOI )

  1. Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone 2011.12; 208 (13): 2641-2655. ( DOI )

  2. Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase 2011.11; 130 (2): 387-398. ( DOI )

  3. Cacalol, a natural sesquiterpene, induces apoptosis in breast cancer cells by modulating Akt-SREBP-FAS signaling pathway 2011.07; 128 (1): 57-68. ( DOI )

  4. KAI1 Gene Is Engaged in NDRG1 Gene-mediated Metastasis Suppression through the ATF3-NFκB Complex in Human Prostate Cancer 2011.05; 286 (21): 18949-18959. ( DOI )

  5. Hyaluronan synthase 2 promotes tumor progression by stimulating interaction of cancer stem -like cells with tumor associated macrophage and stromal cells in the bone 2011.04; 71 ( DOI )

  6. Hypoxia induces Notch signaling and promotes breast cancer metastasis by stimulating growth and self renewal of cancer stem-like cells 2011.04; 71 ( DOI )

  7. Upregulation of lipogenic genes, SREBP-1, ACLY, ACC-1 and FAS, confer proliferation and survival advantages to cancer stem-like cells in ductal carcinoma in situ 2011.04; 71 ( DOI )

  8. NDRG1 pleiotropically suppresses tumor metastasis through modulation of Wnt-βcatenin pathway 2011.02; 28 (2): 188-189.

  1. Metabolic genes in cancer: Their roles in tumor progression and clinical implications 2010.04; 1805 (2): 141-152. ( DOI )

  1. The expression of metastasis suppressor gene, KAI1/CD82, is down-regulated by OCT4, SOX2 and NANOG in tumor stem cells of breast cancer 2009.05; 69

  2. Inhibition of fatty acid synthase and induction of apoptosis in human breast cancer cells by Cacalia deliphiniifolia 2009.05; 69

  3. Resveratrol induces apoptosis by blocking enzymatic activity and destabilizing the protein of fatty acid synthase in breast tumor cells 2009.05; 69

  4. Notch pathway is stimulated by hypoxia and promotes metastasis through activation of EMT and metalloproteinase 2009.05; 69

  5. Molecular Mechanisms of Subcellular Localization of ABCG5 and ABCG8 2009.03; 73 (3): 619-626. ( DOI )

  1. RhoC promotes metastasis via activation of the Pyk2 pathway, in prostate cancer 2008.09; 68 (18): 7613-7620. ( DOI )

  2. Critical role of ADAM15 in tumor progression; targeting multiple factors for metastasis promotion 2008.06; 4 (3): 351-354. ( DOI )

  1. Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1 2007.11; 48 (11): 2377-2384. ( DOI )

  2. Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4 2007.07; 46 (1): 188-199. ( DOI )

  1. Regulation of cancer cell immunogenicity by the Hippo intracellular pathway 2017.10; 68 (4): 438-444.

  1. Toshiro Moroishi, Ayato Maeda, Akihiro Nita, Shoko Sashiyama, Komen Jepkosgei, Yuqing Xu, Yuichiro Arima, Keiichi Nakayama, Kimi Araki, Suzu Yoshitomo: In vivo visualization of bioactive iron and oxygen using the Labile Iron and Oxygen Notifier (LiON) Cell Reports Methods. 2025.06; 6 (6): 101431. ( PubMed , DOI )

  2. Toshiro Moroishi, Yudai OHTA, Yohei KANAMORI, Ayato MAEDA, Mohamed Fathi Saleh, Akihiro NITA, Takashi MATSHMOTO, Keiichi I Nakayama: Iron exacerbates congenital cholestatic liver injury via bile acid-induced ferroptosis The American Journal of Pathology. 2025.05; 196 (3): 700-715. ( PubMed , DOI )

  1. Mayumi Niimura, Yasuhisa Sakamoto, Mayuko Shimoda, Narumi Harada, Ayato Maeda, Shiho Wada, Koki Murata, Saisai Liu, Haruka Ohara, Asuka Iwamoto, Yohei Kanamori, Akihiro Nita, Masahiro Wakao, Yasuo Suda, Hiroyuki Oshiumi, Tomoko Hayashi, Dennis Carson, Hiroyuki Shinchi, Toshiro Moroishi: Harnessing an integrated glyco-nanovaccine technology for enhanced cancer immunotherapy Communications Medicine. 2024.11; 5 (1): 378. ( PubMed , DOI )

  1. Toshiro Moroishi: The Emerging Link between the Hippo Pathway and Non-coding RNA Biological and Pharmaceutical Bulletin. 2020.01; 43 (1): 1-10. ( PubMed , DOI )

  1. Toshiro Moroishi: Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation (vol 19, pg 996, 2017) Nature Cell Biology. 2018; 20 (9): 1098. ( PubMed , DOI )

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