Department of Integrative Stress Science

167  articles.  
* There may be some overlapped articles listed due to the difference of format.

  1. Ueno, H; Iyanaga, Y; Kunida, K; Hara, Y; Miura, H; Nakai, Y; Tanuma, M; Hayashida, M; Yokoyama, R; Ohkubo, J; Seiriki, K; Hayata-Takano, A; Ao, T; Yamaguchi, S; Kitaoka, S; Furuyashiki, T; Ago, Y; Nakazawa, T; Takuma, K; Yoshimoto, J; Hashimoto, H; Kasai, A: Recovery of centralities in medial prefrontal and sensory-related cortices associated with social behavior improvements in an autism mouse model SCIENTIFIC REPORTS. 2025.07; 15 (1): 22895. ( PubMed , DOI )

  2. Volumetric trans-scale imaging of massive quantity of heterogeneous cell populations in centimeter-wide tissue and embryo. 2025.02; 13 ( PubMed , DOI )

  1. Morishita Y, Fuentes I, Gonzalez-Salinas S, Favate J, Mejaes J, Zushida K, Nishi A, Hevi C, Goldsmith N, Buyske S, Sillivan SE, Miller CA, Kandel ER, Uchida S, Shah P, Alarcon JM, Barker DJ, Shumyatsky GP: Dopamine release and dopamine-related gene expression in the amygdala are modulated by the gastrin-releasing peptide in opposite directions during stress-enhanced fear learning and extinction. Molecular psychiatry. 2024.11; 30 (6): 2381-2394. ( PubMed , DOI )

  2. Chen JJ, Kaufmann WA, Chen C, Arai I, Kim O, Shigemoto R, Jonas P: Developmental transformation of Ca(2+) channel-vesicle nanotopography at a central GABAergic synapse. Neuron. 2024.03; 112 (5): 755-771.e9. ( PubMed , DOI )

  3. (R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice. 2024.02; ( PubMed , DOI )

  4. Long-lasting anti-despair and anti-anhedonia effects of (S)-norketamine in social isolation-reared mice. 2024.02; 154 (2): 72-76. ( PubMed , DOI )

  5. Nonaka H, Sakamoto S, Shiraiwa K, Ishikawa M, Tamura T, Okuno K, Kondo T, Kiyonaka S, Susaki EA, Shimizu C, Ueda HR, Kakegawa W, Arai I, Yuzaki M, Hamachi I: Bioorthogonal chemical labeling of endogenous neurotransmitter receptors in living mouse brains. Proceedings of the National Academy of Sciences of the United States of America. 2024.02; 121 (6): e2313887121. ( PubMed , DOI )

  6. Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice. 2024.01; ( PubMed , DOI )

  7. Clozapine Induces Neuronal Activation in the Medial Prefrontal Cortex in a Projection Target-Biased Manner. 2024; 47 (2): 478-485. ( PubMed , DOI )

  1. Nozawa K, Sogabe T, Hayashi A, Motohashi J, Miura E, Arai I, Yuzaki M: In vivo nanoscopic landscape of neurexin ligands underlying anterograde synapse specification. Neuron. 2022.08; 110 (19): 3168-3185.e8. ( PubMed , DOI )

  2. Correction to: Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome. 2022.04; 15 (1): 34. ( PubMed , DOI )

  3. Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses. 2022.03; 8 (11): eabi6375. ( PubMed , DOI )

  4. Fuentes, I; Morishita, Y; Gonzalez-Salinas, S; Champagne, FA; Uchida, S; Shumyatsky, GP: Experience-Regulated Neuronal Signaling in Maternal Behavior FRONTIERS IN MOLECULAR NEUROSCIENCE. 2022.03; 15 844295. ( PubMed , DOI )

  5. Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome. 2022.03; 15 (1): 26. ( PubMed , DOI )

  1. Seki, T; Yamagata, H; Uchida, S; Kobayashi, A; Watanabe, Y; Nakagawa, S: A novel mouse model of postpartum depression using emotional stress as evaluated by nesting behavior SCIENTIFIC REPORTS. 2021.11; 11 (1): 22615. ( PubMed , DOI )

  2. Multiple alterations in glutamatergic transmission and dopamine D2 receptor splicing in induced pluripotent stem cell-derived neurons from patients with familial schizophrenia. 2021.10; 11 (1): 548. ( PubMed , DOI )

  3. Kawatake-Kuno, A; Murai, T; Uchida, S: A Multiscale View of the Mechanisms Underlying Ketamine's Antidepressant Effects: An Update on Neuronal Calcium Signaling FRONTIERS IN BEHAVIORAL NEUROSCIENCE. 2021.09; 15 749180. ( PubMed , DOI )

  4. Exploring rare cellular activity in more than one million cells by a transscale scope 2021.08; 11 (1): ( DOI )

  5. Kawatake-Kuno, A; Murai, T; Uchida, S: The Molecular Basis of Depression: Implications of Sex-Related Differences in Epigenetic Regulation FRONTIERS IN MOLECULAR NEUROSCIENCE. 2021.07; 14 708004. ( PubMed , DOI )

  6. Sakai, Y; Li, HY; Inaba, H; Funayama, Y; Ishimori, E; Kawatake-Kuno, A; Yamagata, H; Seki, T; Hobara, T; Nakagawa, S; Watanabe, Y; Tomita, S; Murai, T; Uchida, S: Gene-environment interactions mediate stress susceptibility and resilience through the CaMKIIβ/TARPγ-8/AMPAR pathway ISCIENCE. 2021.05; 24 (5): 102504. ( PubMed , DOI )

  7. Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZWT/Q1038R mouse model of autism spectrum disorder. 2021.03; 14 (1): 56. ( PubMed , DOI )

  8. Yamagata, H; Ogihara, H; Matsuo, K; Uchida, S; Kobayashi, A; Seki, T; Kobayashi, M; Harada, K; Chen, C; Miyata, S; Fukuda, M; Mikuni, M; Hamamoto, Y; Watanabe, Y; Nakagawa, S: Distinct epigenetic signatures between adult-onset and late-onset depression SCIENTIFIC REPORTS. 2021.01; 11 (1): 2296. ( PubMed , DOI )

  9. Altered Functional Connectivity of the Orbital Cortex and Striatum Associated with Catalepsy Induced by Dopamine D1 and D2 Antagonists. 2021; 44 (3): 442-447. ( PubMed , DOI )

  1. Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain 2020.03; 5 (6): ( PubMed , DOI )

  2. (S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression. 2020.02; 191 172876. ( PubMed , DOI )

  3. Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes. 2020.02; 11 (1): 859. ( PubMed , DOI )

  1. Uchida, S: Epigenetic Mechanisms of Stress Susceptibility and Resilience NEUROPSYCHOPHARMACOLOGY. 2019.12; 44 (SUPPL 1): 116.

  2. Autism-associated protein kinase D2 regulates embryonic cortical neuron development. 2019.11; 519 (3): 626-632. ( PubMed , DOI )

  3. Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome. 2019.11; 44 (12): 2125-2135. ( PubMed , DOI )

  4. Seki, T; Yamagata, H; Uchida, S; Chen, C; Kobayashi, A; Kobayashi, M; Harada, K; Matsuo, K; Watanabe, Y; Nakagawa, S: Altered expression of long noncoding RNAs in patients with major depressive disorder JOURNAL OF PSYCHIATRIC RESEARCH. 2019.10; 117 92-99. ( PubMed , DOI )

  5. (R)-Ketamine Induces a Greater Increase in Prefrontal 5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism. 2019.10; 22 (10): 665-674. ( PubMed , DOI )

  6. Pituitary Adenylate Cyclase-Activating Polypeptide Modulates Dendritic Spine Maturation and Morphogenesis via MicroRNA-132 Upregulation. 2019.05; 39 (22): 4208-4220. ( PubMed , DOI )

  7. Whole-brain block-face serial microscopy tomography at subcellular resolution using FAST. 2019.05; 14 (5): 1509-1529. ( PubMed , DOI )

  8. Takahashi, M; Izawa, K; Urai, M; Yamanishi, Y; Maehara, A; Isobe, M; Matsukawa, T; Kaitani, A; Takamori, A; Uchida, S; Yamada, H; Nagamine, M; Ando, T; Shimizu, T; Ogawa, H; Okumura, K; Kinjo, Y; Kitamura, T; Kitaura, J: The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide-dependent neutrophil recruitment SCIENCE SIGNALING. 2019.01; 12 (564): ( PubMed , DOI )

  1. Uchida, S; Shumyatsky, GP: Epigenetic regulation of Fgf1 transcription by CRTC1 and memory enhancement BRAIN RESEARCH BULLETIN. 2018.07; 141 3-12. ( PubMed , DOI )

  2. Yamagata, H; Uchida, S; Matsuo, K; Harada, K; Kobayashi, A; Nakashima, M; Higuchi, F; Watanuki, T; Matsubara, T; Watanabe, Y: Altered plasma protein glycosylation in a mouse model of depression and in patients with major depression JOURNAL OF AFFECTIVE DISORDERS. 2018.06; 233 79-85. ( PubMed , DOI )

  3. Uchida, S; Yamagata, H; Seki, T; Kobayashi, A; Hara, K; Matsuo, K; Nakagawa, S; Watanabe, Y: HDAC2 Modulates Behavioral Response to Chronic Stress Through Glucocorticoid Receptor BIOLOGICAL PSYCHIATRY. 2018.05; 83 (9): S276. ( DOI )

  4. Uchida, S; Yamagata, H; Seki, T; Watanabe, Y: Epigenetic mechanisms of major depression: Targeting neuronal plasticity PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2018.04; 72 (4): 212-227. ( PubMed , DOI )

  5. Isobe, M; Izawa, K; Sugiuchi, M; Sakanishi, T; Kaitani, A; Takamori, A; Maehara, A; Matsukawa, T; Takahashi, M; Yamanishi, Y; Oki, T; Uchida, S; Uchida, K; Ando, T; Maeda, K; Nakano, N; Yagita, H; Takai, T; Ogawa, H; Okumura, K; Kitamura, T; Kitaura, J: The CD300e molecule in mice is an immune-activating receptor JOURNAL OF BIOLOGICAL CHEMISTRY. 2018.03; 293 (10): 3793-3805. ( PubMed , DOI )

  6. Knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism 2018.03; 19 (3): ( PubMed , DOI )

  7. Uchida, S; Shumyatsky, GP: Synaptically Localized Transcriptional Regulators in Memory Formation NEUROSCIENCE. 2018.02; 370 4-13. ( PubMed , DOI )

  8. Shintani Y, Hayata-Takano A, Moriguchi K, Nakazawa T, Ago Y, Kasai A, Seiriki K, Shintani N, Hashimoto H: β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking. PloS one. 2018; 13 (5): e0196946. ( PubMed , DOI )

  1. Shiihashi G, Ito D, Arai I, Kobayashi Y, Hayashi K, Otsuka S, Nakajima K, Yuzaki M, Itohara S, Suzuki N: Dendritic Homeostasis Disruption in a Novel Frontotemporal Dementia Mouse Model Expressing Cytoplasmic Fused in Sarcoma. EBioMedicine. 2017.10; 24 102-115. ( PubMed , DOI )

  2. Shiihashi, G; Ito, D; Arai, I; Kobayashi, Y; Hayashi, K; Otsuka, S; Nakajima, K; Yuzaki, M; Itohara, S; Suzuki, N: A novel ALS/FTD model mouse expressing cytoplasmic mutant FUS leads neurodegeneration via dendritic homeostasis disruption JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 62. ( DOI )

  3. 樋口 文宏, 内田 周作, 山形 弘隆, 關 友恵, 渡辺 義文: ストレス適応機構におけるヒストン脱アセチル化酵素の役割の解析(The role of histone deacetylase in stress-induced depression-like behavior in mice) 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集. 2017.09; 39回・47回 165. ( ichushi )

  4. 關 友恵, 山形 弘隆, 内田 周作, 原田 健一郎, 松尾 幸治, 渡邉 義文: 大うつ病性障害患者における長鎖非コードRNAの発現解析(Expression profiling of long, noncoding RNAs in patients with major depression) 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集. 2017.09; 39回・47回 170. ( ichushi )

  5. Matsushita M, Nakatake Y, Arai I, Ibata K, Kohda K, Goparaju SK, Murakami M, Sakota M, Chikazawa-Nohtomi N, Ko SBH, Kanai T, Yuzaki M, Ko MSH: Neural differentiation of human embryonic stem cells induced by the transgene-mediated overexpression of single transcription factors. Biochemical and biophysical research communications. 2017.08; 490 (2): 296-301. ( PubMed , DOI )

  6. High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates 2017.06; 94 (6): 1085-+. ( PubMed , DOI )

  7. Yamagata, H; Uchida, S; Matsuo, K; Harada, K; Kobayashi, A; Nakashima, M; Nakano, M; Otsuki, K; Abe-Higuchi, N; Higuchi, F; Watanuki, T; Matsubara, T; Miyata, S; Fukuda, M; Mikuni, M; Watanabe, Y: Identification of commonly altered genes between in major depressive disorder and a mouse model of depression SCIENTIFIC REPORTS. 2017.06; 7 (1): 3044. ( PubMed , DOI )

  8. Wakayama S, Kiyonaka S, Arai I, Kakegawa W, Matsuda S, Ibata K, Nemoto YL, Kusumi A, Yuzaki M, Hamachi I: Chemical labelling for visualizing native AMPA receptors in live neurons. Nature communications. 2017.04; 8 14850. ( PubMed , DOI )

  9. Uchida, S; Teubner, BJW; Hevi, C; Hara, K; Kobayashi, A; Dave, RM; Shintaku, T; Jaikhan, P; Yamagata, H; Suzuki, T; Watanabe, Y; Zakharenko, SS; Shumyatsky, GP: CRTC1 Nuclear Translocation Following Learning Modulates Memory Strength via Exchange of Chromatin Remodeling Complexes on the Fgf1 Gene CELL REPORTS. 2017.01; 18 (2): 352-366. ( PubMed , DOI )

  10. Chen C, Arai I, Satterfield R, Young SM Jr, Jonas P: Synaptotagmin 2 Is the Fast Ca(2+) Sensor at a Central Inhibitory Synapse. Cell reports. 2017.01; 18 (3): 723-736. ( PubMed , DOI )

  1. Abe-Higuchi N, Uchida S, Yamagata H, Higuchi F, Hobara T, Hara K, Kobayashi A, Watanabe Y: Hippocampal Sirtuin 1 Signaling Mediates Depression-like Behavior. Biological psychiatry. 2016.12; 80 (11): 815-826. ( PubMed , DOI )

  2. Martel G, Uchida S, Hevi C, Chévere-Torres I, Fuentes I, Park YJ, Hafeez H, Yamagata H, Watanabe Y, Shumyatsky GP: Genetic Demonstration of a Role for Stathmin in Adult Hippocampal Neurogenesis, Spinogenesis, and NMDA Receptor-Dependent Memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2016.01; 36 (4): 1185-1202. ( PubMed , DOI )

  1. Uchida S, Shumyatsky GP: Deceivingly dynamic: Learning-dependent changes in stathmin and microtubules. Neurobiology of learning and memory. 2015.10; 124 52-61. ( PubMed , DOI )

  2. Understanding Fear Memory Encoding Is Critical for Improving Memory Strength 2015.05; 77 (9): 33S-34S.

  1. Arai I, Jonas P: Nanodomain coupling explains Ca²⁺ independence of transmitter release time course at a fast central synapse. eLife. 2014.12; 3 ( PubMed , DOI )

  2. Uchida S, Martel G, Pavlowsky A, Takizawa S, Hevi C, Watanabe Y, Kandel ER, Alarcon JM, Shumyatsky GP: Learning-induced and stathmin-dependent changes in microtubule stability are critical for memory and disrupted in ageing. Nature communications. 2014.07; 5 4389. ( PubMed , DOI )

  1. Shibata T, Yamagata H, Uchida S, Otsuki K, Hobara T, Higuchi F, Abe N, Watanabe Y: The alteration of hypoxia inducible factor-1 (HIF-1) and its target genes in mood disorder patients. Progress in neuro-psychopharmacology & biological psychiatry. 2013.06; 43 222-229. ( PubMed , DOI )

  1. Murine GRPR and Stathmin Control in Opposite Directions both Cued Fear Extinction and Neural Activities of the Amygdala and Prefrontal Cortex 2012.02; 7 (2): e30942. ( PubMed , DOI )

  2. Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity 2012.02; 5 8. ( PubMed , DOI )

  1. Higuchi F, Uchida S, Yamagata H, Otsuki K, Hobara T, Abe N, Shibata T, Watanabe Y: State-dependent changes in the expression of DNA methyltransferases in mood disorder patients. Journal of psychiatric research. 2011.10; 45 (10): 1295-1300. ( PubMed , DOI )

  2. ストレスによる脳機能障害の分子基盤 気分障害におけるエピジェネティクス(Molecular mechanism of brain dysfunction induced by stress Epigenetic regulation in depression) 2011.10; 21回・41回 105. ( ichushi )

  3. Molecular Basis of Depression エピジェネティクスとストレス脆弱性、うつ病(Molecular Basis of Depression Epigenetic regulation of stress vulnerability and depression) 2011.09; 50 (2-3): 136. ( ichushi )

  4. Abe N, Uchida S, Otsuki K, Hobara T, Yamagata H, Higuchi F, Shibata T, Watanabe Y: Altered sirtuin deacetylase gene expression in patients with a mood disorder. Journal of psychiatric research. 2011.08; 45 (8): 1106-1112. ( PubMed , DOI )

  5. Development of a tightly-regulated tetracycline-dependent transcriptional activator and repressor co-expression system for the strong induction of transgene expression 2011.05; 63 (3): 211-216. ( PubMed , DOI )

  6. Uchida S, Hara K, Kobayashi A, Fujimoto M, Otsuki K, Yamagata H, Hobara T, Abe N, Higuchi F, Shibata T, Hasegawa S, Kida S, Nakai A, Watanabe Y: Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 1. Proceedings of the National Academy of Sciences of the United States of America. 2011.01; 108 (4): 1681-1686. ( PubMed , DOI )

  7. Uchida S, Hara K, Kobayashi A, Otsuki K, Yamagata H, Hobara T, Suzuki T, Miyata N, Watanabe Y: Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events. Neuron. 2011.01; 69 (2): 359-372. ( PubMed , DOI )

  8. Roles of retinoic acid signaling pathway in emotional behavior 2011; 71 E270. ( DOI )

  9. Possible involvement of SIRT1, a histone deacetylase, in neural plasticity and depression-like behavior 2011; 71 E302-E303. ( DOI )

  10. Molecular mechanisms of rapid antidepressant action induced by histone deacetylase inhibitor 2011; 71 E301. ( DOI )

  11. MicroRNA-124 might be involved in the mechanism of depression-like behavior and neuronal plasticity 2011; 71 E303. ( DOI )

  12. Lateral inhibition through electrically-coupled bipolar-cell network in the retina 2011; 71 E13. ( DOI )

  13. BubR1 regulates neurite outgrowth of neuroblastoma cells 2011; 71 E334-E335. ( DOI )

  1. Uchida S, Hara K, Kobayashi A, Funato H, Hobara T, Otsuki K, Yamagata H, McEwen BS, Watanabe Y: Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010.11; 30 (45): 15007-15018. ( PubMed , DOI )

  2. REST4を介した遺伝子発現調節異常はストレス脆弱性を高める(Involvement of REST4-mediated gene regulations in stress vulnerability) 2010.08; 49 (2-3): 676. ( ichushi )

  3. 気分障害患者におけるヒストン脱アセチル化酵素SIRT遺伝子群の発現変化(Altered gene expression of sirtuins in mood disorder patients) 2010.08; 49 (2-3): 677. ( ichushi )

  4. 気分障害患者におけるDNAメチル基転移酵素群遺伝子の発現解析(Altered gene expression of DNA methyltransferases in mood disorder patients) 2010.08; 49 (2-3): 677. ( ichushi )

  5. 抗うつ薬はHDAC4によるヒストン修飾を介してGDNF遺伝子の転写活性を増加させる(Antidepressants increase GDNF gene transcription through the histone modifications by HDAC4) 2010.08; 49 (2-3): 677. ( ichushi )

  6. 前脳領域レチノイン酸受容体情報伝達経路による記憶形成の制御(Regulation of memory formation by Retinoic acid receptors) 2010.08; 49 (2-3): 655. ( ichushi )

  7. ヒストン脱アセチル化酵素阻害剤による抗うつ効果の分子機構の解析(Molecular mechanisms of the antidepressant actions by histone deacetylase inhibitors) 2010.08; 49 (2-3): 676. ( ichushi )

  8. Arai I, Tanaka M, Tachibana M: Active roles of electrically coupled bipolar cell network in the adult retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010.07; 30 (27): 9260-9270. ( PubMed , DOI )

  9. Hobara T, Uchida S, Otsuki K, Matsubara T, Funato H, Matsuo K, Suetsugi M, Watanabe Y: Altered gene expression of histone deacetylases in mood disorder patients. Journal of psychiatric research. 2010.04; 44 (5): 263-270. ( PubMed , DOI )

  10. Otsuki K, Uchida S, Wakabayashi Y, Matsubara T, Hobara T, Funato H, Watanabe Y: Aberrant REST-mediated transcriptional regulation in major depressive disorder. Journal of psychiatric research. 2010.04; 44 (6): 378-384. ( PubMed , DOI )

  11. Uchida S, Hara K, Kobayashi A, Otsuki K, Hobara T, Yamagata H, Watanabe Y: Maternal and genetic factors in stress-resilient and -vulnerable rats: a cross-fostering study. Brain research. 2010.02; 1316 43-50. ( PubMed , DOI )

  12. Hobara, T; Uchida, S; Otsuki, K; Yamagata, H; Watanabe, Y: Molecular mechanisms of the antidepressant actions by histone deacetylase inhibitors NEUROSCIENCE RESEARCH. 2010; 68 E316. ( DOI )

  13. Uchida, S; Hara, K; Kobayashi, A; Watanabe, Y: Involvement of REST4-mediated gene regulations in stress vulnerability NEUROSCIENCE RESEARCH. 2010; 68 E316. ( DOI )

  14. Otsuki, K; Uchida, S; Yamagata, H; Watanabe, Y: Antidepressants increase GDNF gene transcription through the histone modifications by HDAC4 NEUROSCIENCE RESEARCH. 2010; 68 E317. ( DOI )

  15. Abe, N; Uchida, S; Otsuki, K; Hobara, T; Higuchi, F; Watanabe, Y: Altered gene expression of sirtuins in mood disorder patients NEUROSCIENCE RESEARCH. 2010; 68 E318. ( DOI )

  16. Higuchi, F; Uchida, S; Otsuki, K; Teruyuki, H; Abe, N; Watanabe, Y: Altered gene expression of DNA methyltransferases in mood disorder patients NEUROSCIENCE RESEARCH. 2010; 68 E318. ( DOI )

  1. Positive and negative regulation of memory formation by Retinoic acid receptors 2009; 65 S234. ( DOI )

  2. Function of electrical synapses among retinal bipolar cells 2009; 65 S14. ( DOI )

  3. FUNCTIONAL SIGNIFICANCE OF GAP JUNCTIONS AMONG RETINAL BIPOLAR CELLS 2009; 59 32.

  4. Uchida, S; Otsuki, K; Hara, K; Kobayashi, A; Hobara, T; Watanabe, Y: HDAC2-mediated epigenetic repression of the GDNF gene in the striatum modulates behavioral vulnerability to stress NEUROSCIENCE RESEARCH. 2009; 65 S184. ( DOI )

  5. Hobara, T; Uchida, S; Otsuki, K; Matsubara, T; Funato, H; Matsuo, K; Suetsugi, M; Watanabe, Y: Altered gene expression of histone deacetylases in mood disorder patients NEUROSCIENCE RESEARCH. 2009; 65 S90. ( DOI )

  6. Otsuki, K; Uchida, S; Watanabe, Y: Antidepressant drugs upregurate glial astrocyte GDNF gene transcription throgh the histone modifications NEUROSCIENCE RESEARCH. 2009; 65 S254. ( DOI )

  1. Otsuki, K; Uchida, S; Watanuki, T; Wakabayashi, Y; Fujimoto, M; Matsubara, T; Funato, H; Watanabe, Y: Altered expression of neurotrophic factors in patients with major depression JOURNAL OF PSYCHIATRIC RESEARCH. 2008.10; 42 (14): 1145-1153. ( PubMed , DOI )

  2. Watanuki, T; Funato, H; Uchida, S; Matsubara, T; Kobayashi, A; Wakabayashi, Y; Otsuki, K; Nishida, A; Watanabe, Y: Increased expression of splicing factor SRp20 mRNA in bipolar disorder patients JOURNAL OF AFFECTIVE DISORDERS. 2008.09; 110 (1-2): 62-69. ( PubMed , DOI )

  3. 発達期うつ様行動のリスク下における転写抑制因子REST/NRSFを介した遺伝子発現調節の役割(Role of REST/NRSF repressor-mediated gene regulations in the risk of developing depression-like behavior) 2008.08; 47 (2-3): 249. ( ichushi )

  4. Wakabayashi, Y; Uchida, S; Funato, H; Matsubara, T; Watanuki, T; Otsuki, K; Fujimoto, M; Nishida, A; Watanabe, Y: State-dependent changes in the expression levels of NCAM-140 and L1 in the peripheral blood cells of bipolar disorders, but not in the major depressive disorders PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2008.07; 32 (5): 1199-1205. ( PubMed , DOI )

  5. Fujimoto, M; Uchida, S; Watanuki, T; Wakabayashi, Y; Otsuki, K; Matsubara, T; Suetsugi, M; Funato, H; Watanabe, Y: Reduced expression of glyoxalase-1 mRNA in mood disorder patients NEUROSCIENCE LETTERS. 2008.06; 438 (2): 196-199. ( PubMed , DOI )

  6. Fujimoto, J; Bando, T; Minoshima, M; Uchida, S; Iwasaki, M; Shinohara, K; Sugiyama, H: Detection of triplet repeat sequences in the double-stranded DNA using pyrene-functionalized pyrrole-imidazole polyamides with rigid linkers BIOORGANIC & MEDICINAL CHEMISTRY. 2008.06; 16 (11): 5899-5907. ( PubMed , DOI )

  7. Uchida, S; Nishida, A; Hara, K; Kamemoto, T; Suetsugi, M; Fujimoto, M; Watanuki, T; Wakabayashi, Y; Otsuki, K; McEwen, BS; Watanabe, Y: Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor EUROPEAN JOURNAL OF NEUROSCIENCE. 2008.05; 27 (9): 2250-2261. ( PubMed , DOI )

  8. Fujimoto, M; Uchida, S; Hara, K; Watanabe, Y: Morphological alterations of hippocampal pyramidal neurons induced by chronic stress in F344 rats PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2008.02; 62 (1): S8.

  9. Morphological alterations of hippocampal pyramidal neurons induced by chronic stress in F344 rats 2008.02; 62 (1): S8.

  10. Otsuki, K; Uchida, S; Watanuki, T; Wakabayashi, Y; Matsubara, T; Watanabe, Y: Expression analysis of neurotrophic factors in patients with mood disorders PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2008.02; 62 (1): S14.

  11. Retinoic acid receptors function as positive regulators for memory formation 2008; 61 S193.

  12. Electrical synapses among retinal bipolar cells Itaru Arai, Sachi Majima, Masao Tachibana 2008; 61 S101.

  13. Involvement of REST/NRSF repressor-mediated gene regulations in the risk of developing depression-like behavior in the maternally separated rats 2008; 61 S207.

  14. Otsuki, K; Uchida, S; Hara, K; Kobayashi, A; Watanabe, Y: Involvement of glucocorticoids-mediated downregulation of GDNF expression in the susceptibility to chronic ultra mild stress NEUROSCIENCE RESEARCH. 2008; 61 S206.

  15. Involvement of glucocorticoids-mediated downregulation of GDNF expression in the susceptibility to chronic ultra mild stress 2008; 61 S206.

  1. Suetsugi, M; Mizuki, Y; Yamamoto, K; Uchida, S; Watanabe, Y: The effect of placebo administration on the first-night effect in healthy young volunteers PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2007.05; 31 (4): 839-847. ( PubMed , DOI )

  2. Chronic reduction in dietary tryptophan leads to a selective impairment of contextual fear memory in mice 2007.05; 1149 149-156. ( PubMed , DOI )

  3. Wakabayashi, Y; Uchida, S; Matsubara, T; Funato, H; Kobayashi, A; Nishida, A; Watanabe, Y: Expression analysis of cell adhesion molecules in mood disorders PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2007.04; 61 (2): S6.

  4. Expression analysis of cell adhesion molecules in mood disorders 2007.04; 61 (2): S6.

  5. Expression analysis of adhesion molecule CD44 isoform mRNA in the patients with mood disorders 2007; 58 S124.

  6. Otsuki, K; Uchida, S; Matsubara, T; Watanuki, T; Wakabayashi, Y; Watanabe, Y: Expression analysis of neurotrophic factors in patients with mood disorders NEUROSCIENCE RESEARCH. 2007; 58 S123. ( DOI )

  7. Watanuki, T; Uchida, S; Funato, H; Otsuki, K; Wakabayashi, Y; Watanabe, Y: Expression analysis of adhesion molecule CD44 isoform mRNA in the patients with mood disorders NEUROSCIENCE RESEARCH. 2007; 58 S124. ( DOI )

  8. Roles of retinoic acid receptors in learning and memory 2007; 58 S111.

  9. Uchida, S; Nishida, A; Hara, K; Suetsugi, M; Fujimoto, M; Watanabe, Y: Involvement of microRNA-mediated downregulation of glucocorticoid receptor in vulnerability to stress NEUROSCIENCE RESEARCH. 2007; 58 S166. ( DOI )

  10. Involvement of microRNA-mediated downregulation of glucocorticoid receptor in vulnerability to stress 2007; 58 S166.

  11. Expression analysis of neurotrophic factors in patients with mood disorders 2007; 58 S123.

  1. Tight regulation of transgene expression by tetracycline-dependent activator and repressor in brain 2006.02; 5 (1): 96-106. ( PubMed , DOI )

  2. Expression analysis of alternative splicing-related SR protein family in patients with mood disorders 2006; 55 S233.

  3. Watanuki, T; Funato, H; Matsubara, T; Uchida, S; Watanabe, Y: Expression analysis of alternative splicing-related SR protein family in patients with mood disorders NEUROSCIENCE RESEARCH. 2006; 55 S233.

  1. Chronic reduction in dietary tryptophan leads to changes in the emotional response to stress in mice 2005.06; 51 (3): 175-181. ( PubMed , DOI )

  2. Uchida Shusaku, Kitamoto Aya, Umeeda Hisahiro, Nakagawa Nobutoshi, Masushige Shoichi, Kida Satoshi: マウスにおいて食餌中慢性的トリプトファン減少はストレスに対する情動反応に変化を来たす(Chronic Reduction in Dietary Tryptophan Leads to Changes in the Emotional Response to Stress in Mice) Journal of Nutritional Science and Vitaminology. 2005.06; 51 (3): 175-181. ( ichushi )

  3. Hosoi N, Arai I, Tachibana M: Group III metabotropic glutamate receptors and exocytosed protons inhibit L-type calcium currents in cones but not in rods. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005.04; 25 (16): 4062-4072. ( PubMed , DOI )

  1. Arai I, Yamada Y, Asaka T, Tachibana M: Light-evoked oscillatory discharges in retinal ganglion cells are generated by rhythmic synaptic inputs. Journal of neurophysiology. 2004.08; 92 (2): 715-725. ( PubMed , DOI )

  1. Kaoru Seiriki: [Development of a Whole-brain Imaging System at Subcellular Resolution for Analysis of Animal Models of Neuropsychiatric Disorders]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2019; 139 (12): 1501-1507. ( PubMed , DOI )

  1. Kaoru Seiriki, Atsushi Kasai, Hitoshi Hashimoto: Whole-brain imaging analysis of animal models of neuropsychiatric disorders Japanese Journal of Biological Psychiatry. 2018.03; 29 (1): 22-26.

  1. 内田周作, 樋口尚子, 山形弘隆, 渡辺義文: うつ病・不安障害におけるサーチュインの役割と創薬への可能性 日本神経精神薬理学会プログラム・抄録集. 2017.09; 39回・47回 111. ( ichushi )

  2. 山形弘隆, 内田周作, 松尾幸治, 原田健一郎, 宮田茂雄, 福田正人, 三國雅彦, 三國雅彦, 三國雅彦, 渡邉義文: うつ病患者白血球とうつ病モデルマウス血液に共通した遺伝子発現変化 日本神経精神薬理学会プログラム・抄録集. 2017.09; 39回・47回 168. ( ichushi )

  1. 山形弘隆, 内田周作, 樋口文宏, 芳原輝之, 渡邉義文, 渡邉義文: BubR1を介した神経突起伸展の制御 日本生物学的精神医学会(Web). 2016; 38th 120 (WEB ONLY).

  2. 内田周作, 山形弘隆, 芳原輝之, 樋口文宏, 樋口尚子, 渡辺義文: ストレス適応破綻からみたうつ病態における神経可塑性異常とその分子基盤 日本生物学的精神医学会(Web). 2016; 38th 2 (WEB ONLY).

  3. 山形弘隆, 内田周作, 樋口文宏, 渡邉義文: うつ病と神経細胞死 日本生物学的精神医学会(Web). 2016; 38th 19 (WEB ONLY).

  4. 渡辺義文, 内田周作, 山形弘隆, 樋口文宏: うつ病の発病脆弱性の分子機構を考える 日本生物学的精神医学会(Web). 2016; 38th 17 (WEB ONLY).

  1. 内田周作, 内田周作, 芳原輝之, 樋口文宏, 樋口尚子, 山形弘隆, 渡邉義文: エピジェネティクスによるうつ病の分子・細胞基盤 日本神経精神薬理学会プログラム・抄録集. 2015.09; 37回・45回 96. ( ichushi )

  2. 内田周作, 内田周作, 樋口尚子, 山形弘隆, 芳原輝之, 樋口文宏, 渡邉義文: レジリエンスの視点からうつ病の発症・回復の分子メカニズムを理解する 日本神経精神薬理学会プログラム・抄録集. 2015.09; 37回・45回 91. ( ichushi )

  3. 山形弘隆, 内田周作, 芳原輝之, 樋口文宏, 原田健一郎, 松尾幸治, 三國雅彦, 渡邉義文: レクチンアレイを用いたうつ病患者血漿タンパク質の糖鎖解析 日本神経精神薬理学会プログラム・抄録集. 2015.09; 37回・45回 197. ( ichushi )

  4. 樋口文宏, 内田周作, 山形弘隆, 芳原輝之, 樋口尚子, 渡邉義文: うつ様行動と神経可塑性におけるmicroRNA‐124の役割の解析 先進医薬研究振興財団 2014年度 研究成果報告集. 2015; 50-51.

  1. 芳原輝之, 阿部尚子, 内田周作, 山形弘隆, 樋口文宏, 大朏孝治, 渡邉義文: ヒストン脱アセチル化酵素(SIRT1)のうつ状態,抗うつ薬作用機序への関与の検討 精神薬療研究年報. 2014.03; (46): 66-67. ( ichushi )

  2. 山形弘隆, 内田周作, 芳原輝之, 樋口文宏, 渡邉義文: 慢性ストレス負荷BALB/cマウスの海馬における遺伝子発現マイクロアレイ解析 日本生物学的精神医学会誌. 2014; 339.

  1. 大朏孝治, 内田周作, 山形弘隆, 芳原輝之, 渡邉義文: 抗うつ効果の早期発現を実現する薬物治療法の開発 精神薬療研究年報. 2013.03; (45): 73-74. ( ichushi )

  1. Koji Otsuki, Shusaku Uchida, Teruyuki Hobara, Hirotaka Yamagata, Yoshifuini Watanabe: Epigenetic regulation in depression Japanese Journal of Neuropsychopharmacology. 2012.08; 32 (4): 181-186. ( PubMed )

  1. OTSUKI Koji, UCHIDA Shusaku, HOBARA Teruyuki, WATANABE Yoshifumi: Epigenetic regulation in depression 2011.06; 22 (2): 89-95.

  1. 山形弘隆, 内田周作, 渡邉義文: うつ病と神経可塑性に対するBubR1の役割 日本生物学的精神医学会誌. 2010.10; 21 (Supplement): 151.

  2. 柴田朋彦, 山形弘隆, 内田周作, 渡邉義文: アポトーシス制御因子であるBH3‐only proteinのうつ病における役割 日本生物学的精神医学会誌. 2010.10; 21 (Supplement): 153.

  1. Glucocorticoid receptor Japanese journal of molecular psychiatry. 2008.01; 8 (1): 61-64.

  1. 綿貫 俊夫, 船戸 弘正, 内田 周作, 松原 敏郎, 若林 祐介, 大朏 孝治, 西田 朗, 渡邉 義文: 気分障害患者における選択的スプライシング調節機構異常の検討 精神薬療研究年報. 2007.03; (39): 59-65. ( ichushi )

  1. 綿貫 俊夫, 松原 敏郎, 船戸 弘正, 内田 周作, 西田 朗, 渡邉 義文: 気分障害患者におけるグルココルチコイド受容体の発現異常と機能障害の統合的検討 精神薬療研究年報. 2006.03; (38): 146-154. ( ichushi )

  1. Kida S, Uchida S: [Regulation of emotional behavior by nuclear receptors]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 2005.01; 125 (1): 17-24. ( PubMed , DOI )

  1. Tachibana M, Hosoi N, Arai I: 2SC05 Feedback Regulation of Ca Current in Photoreceptors Seibutsu Butsuri. 2004; 44 S16. ( DOI )

  1. Kaoru Seiriki, Shunsuke Maeda, Leo Kojima, Yuzuka Fujimoto, Taiyou Baba, Hiroki Rokujo, Tomoki Nitta, Takanobu Nakazawa, Atsushi Kasai, Takatoshi Hikida, Hitoshi Hashimoto: Noradrenergic efferent subsystems that gate traumatic social learning 2025.03; ( DOI )

  1. Leo Kojima, Kaoru Seiriki, Hiroki Rokujo, Takanobu Nakazawa, Atsushi Kasai, Hitoshi Hashimoto: Optimization of AAV vectors for transactivator-regulated enhanced gene expression within targeted neuronal populations iScience. 2024.06; ( DOI )

  2. Kohei Kitagawa, Tomoya Takemoto, Kaoru Seiriki, Atsushi Kasai, Hitoshi Hashimoto, Takanobu Nakazawa: Socially activated neurons in the anterior cingulate cortex are essential for social behavior in mice Biochemical and Biophysical Research Communications. 2024.06; 150251. ( DOI )

  3. Ayako Kawatake-Kuno, Haiyan Li, Hiromichi Inaba, Momoka Hikosaka, Erina Ishimori, Takatoshi Ueki, Yury Garkun, Hirofumi Morishita, Shuh Narumiya, Naoya Oishi, Gen Ohtsuki, Toshiya Murai, Shusaku Uchida: Sustained antidepressant effects of ketamine metabolite involve GABAergic inhibition-mediated molecular dynamics in aPVT glutamatergic neurons Neuron. 2024.02; 112 (8): 1265-1285.e10. ( PubMed , DOI )

  1. Yukihiro Itoh, Peng Zhan, Toshifumi Tojo, Pattaporn Jaikhan, Yosuke Ota, Miki Suzuki, Ying Li, Zi Hui, Yukiko Moriyama, Yuri Takada, Yasunobu Yamashita, Makoto Oba, Shusaku Uchida, Mitsuharu Masuda, Shinji Ito, Yoshihiro Sowa, Toshiyuki Sakai, Takayoshi Suzuki: Discovery of Selective Histone Deacetylase 1 and 2 Inhibitors: Screening of a Focused Library Constructed by Click Chemistry, Kinetic Binding Analysis, and Biological Evaluation Journal of Medicinal Chemistry. 2023.10; 66 (22): 15171-15188. ( PubMed , DOI )

  2. Hiromichi Inaba, Haiyan Li, Ayako Kawatake-Kuno, Ken-ichi Dewa, Jun Nagai, Naoya Oishi, Toshiya Murai, Shusaku Uchida: GPCR-mediated calcium and cAMP signaling determines psychosocial stress susceptibility and resiliency Science Advances. 2023.04; 9 (14): eade5397. ( PubMed , DOI )

  3. Yuma Nagai, Yuri Kisaka, Kento Nomura, Naoya Nishitani, Chihiro Andoh, Masashi Koda, Hiroyuki Kawai, Kaoru Seiriki, Kazuki Nagayasu, Atsushi Kasai, Hisashi Shirakawa, Takanobu Nakazawa, Hitoshi Hashimoto, Shuji Kaneko: Dorsal raphe serotonergic neurons preferentially reactivate dorsal dentate gyrus cell ensembles associated with positive experience Cell Reports. 2023.03; 42 (3): 112149. ( PubMed , DOI )

  1. Masato Tanuma, Misaki Niu, Jin Ohkubo, Hiroki Ueno, Yuka Nakai, Yoshihisa Yokoyama, Kaoru Seiriki, Hitoshi Hashimoto, Atsushi Kasai: Acute social defeat stress activated neurons project to the claustrum and basolateral amygdala Molecular Brain. 2022.12; 15 (1): ( PubMed , DOI )

  2. Margret Shirinian, Chong Chen, Shusaku Uchida, Nafisa M Jadavji: Editorial: The role of epigenetics in neuropsychiatric disorders Frontiers in Molecular Neuroscience. 2022.07; 15 985023. ( PubMed , DOI )

  3. Yuki Funayama, Haiyan Li, Erina Ishimori, Ayako Kawatake-Kuno, Hiromichi Inaba, Hirotaka Yamagata, Tomoe Seki, Shin Nakagawa, Yoshifumi Watanabe, Toshiya Murai, Naoya Oishi, Shusaku Uchida: Antidepressant Response and Stress Resilience Are Promoted by CART Peptides in GABAergic Neurons of the Anterior Cingulate Cortex Biological Psychiatry Global Open Science. 2022.01; 3 (1): 87-98. ( PubMed , DOI )

  1. Yoshikazu Morishita, Ileana Fuentes, John Favate, Ko Zushida, Akinori Nishi, Charles Hevi, Noriko Goldsmith, Steve Buyske, Stephanie E. Sillivan, Courtney A. Miller, Eric R. Kandel, Shusaku Uchida, Premal Shah, Gleb P. Shumyatsky: The gastrin-releasing peptide regulates stress-enhanced fear and dopamine signaling 2021.01; ( DOI )

  1. Taro Ichimura, Taishi Kakizuka, Kazuki Horikawa, Kaoru Seiriki, Atsushi Kasai, Hitoshi Hashimoto, Katsumasa Fujita, Tomonobu M. Watanabe, Takeharu Nagai: Trans-scale-scope to find rare cellular activity in sub-million cells 2020.06; ( DOI )

  1. Fumihiro Higuchi, Shusaku Uchida, Hirotaka Yamagata, Naoko Abe-Higuchi, Teruyuki Hobara, Kumiko Hara, Ayumi Kobayashi, Tatsushi Shintaku, Yukihiro Itoh, Takayoshi Suzuki, Yoshifumi Watanabe: Hippocampal microRNA-124 enhances chronic stress resilience in mice Journal of Neuroscience. 2016.07; 36 (27): 7253-7267. ( PubMed , DOI )

  1. Watanabe Y, Uchida S, Otsuki K, Yamagata H, Hobara T, Abe N, Higuchi F, Watanuki T, Matsubara T: [Functional biomarkers of mood disorders: differential diagnosis and clinical classification with gene expression in peripheral leukocytes]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. 2012; 114 (7): 812-820. ( PubMed )

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