Advanced Pathophysiological Science

434  articles.  
* There may be some overlapped articles listed due to the difference of format.

  1. Nduru, D; Ohta, Y; Nita, A; Niimura, M; Ngurari, S; Moroishi, T: A YAP/TAZ-CDC6 Axis Initiates and Maintains Malignant Transformation CANCER SCIENCE. 2026.02; 117 (2): 353-363. ( PubMed , DOI )

  2. Kurata, H; Ngurari, S; Nita, A; Sakamoto, Y; Nduru, D; Moroishi, T: A kinase inhibitor screen identifies GSK690693 as a Hippo pathway inhibitor targeting ER-positive breast cancer JOURNAL OF BIOCHEMISTRY. 2026.01; ( PubMed , DOI )

  1. Norizuki T, Kushida Y, Sekimoto T, Sasaki T, Yamano K, Matsuda N, Sasaki R, Noda NN, Sato K, Sato M: ALLO-1a is a ubiquitin-binding adaptor for allophagy in Caenorhabditis elegans. Journal of Cell Science. 2025.12; 138 (24): jcs264252.. ( PubMed , DOI )

  2. Saleh, MF; Nita, A; Ohta, Y; Kobayashi, A; Li, H; Sakamoto, Y; Moroishi, T: Hippo Pathway Drives Durable Non-Cell-Autonomous Ferroptosis Resistance in Lung Cancer CANCER SCIENCE. 2025.12; ( PubMed , DOI )

  3. Maeda, A; Nita, A; Moroishi, T: Glutamine metabolism drives B cell proliferation under elevated atmospheric pressure BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2025.11; 790 152892. ( PubMed , DOI )

  4. Harada, N; Niimura, M; Sakamoto, Y; Nita, A; Shimoda, M; Wada, S; Murata, K; Wakao, M; Kamba, T; Shinchi, H; Moroishi, T: Peptide Modulation Overrides Glycan Synergy in Gold Nanoparticle-Based Vaccines for Cancer Immunotherapy CANCER MEDICINE. 2025.10; 14 (19): e71286. ( PubMed , DOI )

  5. Saisai Liu, Yohei Kanamori, Yudai Ohta, Shuran Li, Yanliang Liu, Hao Li, Mohamed Fathi Saleh, Akihiro Nita, Keiichi I. Nakayama, Toshiro Moroishi: Iron overload in CD11c+ myeloid cells exacerbates acetaminophen hepatotoxicity Communications Biology. 2025.10; 8 (1): 1488. ( PubMed , DOI )

  6. Liu Yanliang, Liu Saisai, Sakamoto Yasuhisa, Chunthaboon Paweenapon, Thinyakul Chanida, Mori Ryunosuke, Li Shuran, Watanabe-Nakayama Takahiro, Omata Seiji, Morita Yasuyuki, Moroishi Toshiro: LATS1/2-Integrin Axis Confers Tumor-Generated Forces That Activate Neighboring Fibroblasts(タイトル和訳中) Cancer Science. 2025.09; 116 (9): 2486-2498. ( ichushi )

  7. Yohei Kanamori, Akihiro Nita, Keiichi I. Nakayama, Daisuke Kurotaki, Kenichi Harada, Toshiro Moroishi: Hepatocyte iron suppresses liver fibrosis via fibrolytic neutrophil recruitment in cholestasis JHEP Reports. 2025.09; 7 (12): 101590. ( PubMed , DOI )

  8. Kei Okatsu, Reika Kikuchi, Noriyuki Matsuda, Shuya Fukai, and Koji Yamano: Functional and structural insights into complex formation between OPTN leucine zipper domain and RAB8A. Genes to Cells. 2025.08; 30 (5): e70043.

  9. Watanabe A, Ogiwara S, Saito M, Mishima M, Yamashina M, Ishitani R, Ito Y, Tanaka K, Koyano F, Yamano K, Kosako H, Moriwaki Y, Matsuda N: The reaction mechanism for glycolysis side product degradation by Parkinson's disease-linked DJ-1. Journal of Cell Biology. 2025.08; 224 (8): e202411078.. ( PubMed , DOI )

  10. Li, H; Li, SR; Kanamori, Y; Liu, SS; Moroishi, T: Auranofin resensitizes ferroptosis-resistant lung cancer cells to ferroptosis inducers BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2025.07; 770 151992. ( PubMed , DOI )

  11. Li, H; Kanamori, Y; Nita, A; Maeda, A; Zhang, TL; Kikuchi, K; Yamada, H; Toyomoto, T; Saleh, MF; Niimura, M; Hinokuma, H; Shimoda, M; Ikeda, K; Suzuki, M; Komohara, Y; Kurotaki, D; Sawa, T; Moroishi, T: Hippo pathway controls biopterin metabolism to shield adjacent cells from ferroptosis in lung cancer EMBO REPORTS. 2025.07; 26 (16): 4124-4152. ( PubMed , DOI )

  12. Kodai Nakamura, Huascar-Pedro Ortuste-Quiroga, Naoki Horii, Shin Fujimaki, Toshiro Moroishi, Keiichi I. Nakayama, Shinjiro Hino, Yoshihiko Saito, Ichizo Nishino, Yusuke Ono: Iron supplementation alleviates pathologies in a mouse model of facioscapulohumeral muscular dystrophy Journal of Clinical Investigation. 2025.07; 135 (17): ( PubMed , DOI )

  13. Liu, YL; Liu, SS; Sakamoto, Y; Chunthaboon, P; Thinyakul, C; Mori, R; Li, SR; Watanabe-Nakayama, T; Omata, S; Morita, Y; Moroishi, T: LATS1/2-Integrin Axis Confers Tumor-Generated Forces That Activate Neighboring Fibroblasts CANCER SCIENCE. 2025.07; 116 (9): 2486-2498. ( PubMed , DOI )

  14. Kanayama M, Izumi Y, Onai N, Akashi T, Hiraoka Y, Ohteki T.: Diverse developmental pathways of lymphoid conventional dendritic cells with distinct tissue distribution and function Science Advances. 2025.06; 11 (23): eadt4909. ( DOI )

  15. Zoledronic acid attenuates ischemic brain injury by promoting ETS2 and MSR1 expression. 2025.06; 37 (7): 393-402. ( PubMed , DOI )

  16. Matsumoto, T; Nita, A; Kanamori, Y; Maeda, A; Nita, T; Yasuda-Yoshihara, N; Mima, K; Okabe, H; Imai, K; Hayashi, H; Matsuoka, Y; Nagaoka, K; Nakayama, KI; Sugiura, Y; Tanaka, Y; Baba, H; Moroishi, T: Integrated hepatic ferroptosis gene signature dictates pathogenic features of ferroptosis HEPATOLOGY COMMUNICATIONS. 2025.06; 9 (6): ( PubMed , DOI )

  17. Shoko Sashiyama, Tadashi Nakagawa, Makiko Nakagawa, Masaki Hosogane, Yasuaki Watanabe, Honoka Ashitomi, Kazusa Yamane, Norihiro Shibuya, Toshiro Moroishi, Keiko Nakayama, Toru Hosoi: KBG syndrome-associated protein ANKRD11 regulates SETD5 expression to modulate rRNA levels and translation iScience. 2025.05; 28 (6): 112699. ( PubMed , DOI )

  18. Seiichiro Sakai, Kento Otani, Jun Tsuyama, Yuichiro Hara, Ko Abe, Teppei Shimamura, Ito Kawakami, Takashi Komori, Hideya Kawaji, Koji Hase, Takashi Saito, Takashi Shichita: Anti-amyloid beta therapy resolves stroke recovery impairment caused by Alzheimer's disease bioRxiv. 2025.05; ( DOI )

  19. Nakagawa S, Sato T, Ohashi E, Kajita M, Miya F, Yamamoto K, Yotsumata H, Yamaguchi K, Nakajima Y, Miura A, Kinugasa Y, and Ohteki T.: An organoid library of human esophageal squamous cell carcinomas (ESCCs) uncovers the chemotherapy-resistant ESCC features Communications Biology. 2025.04; 8 (1): 507. ( DOI )

  20. Miwako Sase, Taku Sato, Hajime Sato, Fuyuki Miya, Shicheng Zhang, Hiroshi Haeno, Mihoko Kajita, Tadahide Noguchi, Yoshiyuki Mori, Toshiaki Ohteki: Comparative analysis of tongue cancer organoids among patients identifies the heritable nature of minimal residual disease. Dev Cell. 2025.02; 60 (3): 396-413.e6. ( PubMed , DOI )

  21. Tatsuya Morishima, Md Fakruddin, Yohei Kanamori, Takeshi Masuda, Akiko Ogawa, Yuxin Wang, Vivien A C Schoonenberg, Falk Butter, Yuichiro Arima, Takaaki Akaike, Toshiro Moroishi, Kazuhito Tomizawa, Toshio Suda, Fan-Yan Wei, Hitoshi Takizawa: Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis. Science advances. 2025.02; 11 (8): eadu3011. ( PubMed , DOI )

  22. Fumika Koyano, Noriyuki Matsuda: Quality control of ABCD3 by the VCP-FAF2 complex suppresses excessive pexophagy. Autophagy. 2025.02; 21 (5): 1169-1170. ( PubMed , DOI )

  23. Pawaret Panyajai, Natsima Viriyaadhammaa, Sawitree Chiampanichayakul, Yasuhisa Sakamoto, Siriporn Okonogi, Toshiro Moroishi, Songyot Anuchapreeda: Anticancer and cancer preventive activities of shogaol and curcumin from Zingiberaceae family plants in KG-1a leukemic stem cells BMC Complementary Medicine and Therapies. 2025.02; 25 (1): ( DOI )

  1. Huihui Xiang, Rika Kasajima, Koichi Azuma, Tomoyuki Tagami, Asami Hagiwara, Yoshiro Nakahara, Haruhiro Saito, Yuka Igarashi, Feifei Wei, Tatsuma Ban, Mitsuyo Yoshihara, Yoshiyasu Nakamura, Shinya Sato, Shiro Koizume, Tomohiko Tamura, Tetsuro Sasada, Yohei Miyagi.: Multi-omics analysis-based clinical and functional significance of a novel prognostic and immunotherapeutic gene signature derived from amino acid metabolism pathways in lung adenocarcinoma Frontiers in Immunology. 2024.12; 13 (15): 1361992. ( PubMed , DOI )

  2. Yumoto Shinsei, Horiguchi Haruki, Kadomatsu Tsuyoshi, Horino Taichi, Sato Michio, Terada Kazutoyo, Miyata Keishi, Moroishi Toshiro, Baba Hideo, Oike Yuichi: Host ANGPTL2 establishes an immunosuppressive tumor microenvironment and resistance to immune checkpoint therapy(タイトル和訳中) Cancer Science. 2024.12; 115 (12): 3846-3858. ( ichushi )

  3. Morishita Y, Fuentes I, Gonzalez-Salinas S, Favate J, Mejaes J, Zushida K, Nishi A, Hevi C, Goldsmith N, Buyske S, Sillivan SE, Miller CA, Kandel ER, Uchida S, Shah P, Alarcon JM, Barker DJ, Shumyatsky GP: Dopamine release and dopamine-related gene expression in the amygdala are modulated by the gastrin-releasing peptide in opposite directions during stress-enhanced fear learning and extinction. Molecular psychiatry. 2024.11; 30 (6): 2381-2394. ( PubMed , DOI )

  4. Fumika Koyano, Koji Yamano, Tomoyuki Hoshina, Hidetaka Kosako, Yukio Fujiki, Keiji Tanaka, Noriyuki Matsuda: AAA+ ATPase chaperone p97/VCP(FAF2) governs basal pexophagy. Nature communications. 2024.10; 15 (1): 9347. ( PubMed , DOI )

  5. Yasuhisa Sakamoto, Akiyoshi Uezu, Koji Kikuchi, Jangmi Kang, Eiko Fujii, Toshiro Moroishi, Shiro Suetsugu, Hiroyuki Nakanishi: The Nedd4L ubiquitin ligase is activated by FCHO2-generated membrane curvature The EMBO Journal. 2024.10; ( DOI )

  6. Chanida Thinyakul, Yasuhisa Sakamoto, Mayuko Shimoda, Yanliang Liu, Suyanee Thongcho, Omnia Reda, Akihiro Nita, Romgase Sakamula, Somponnat Sampattavanich, Ayato Maeda, Paweenapon Chunthaboon, David Nduru, Mayumi Niimura, Yohei Kanamori, Peti Thuwaji, Keiichi I. Nakayama, Kun-Liang Guan, Yorifumi Satou, Chanitra Thuwaji, Toshiro Moroishi: Hippo pathway in cancer cells induces NCAM1+αSMA+ fibroblasts to modulate tumor microenvironment Communications Biology. 2024.10; 7 (1): 1343. ( PubMed , DOI )

  7. Tomoya Yamashita, Haruki Horiguchi, Tsuyoshi Kadomatsu, Michio Sato, Toshiro Moroishi, Yuichi Oike: Immunotherapy-induced reprogramming of cancer-associated fibroblasts can promote tumor progression. Genes to cells : devoted to molecular & cellular mechanisms. 2024.10; 29 (12): 1275-1283. ( PubMed , DOI )

  8. Endo R, Kinefuchi H, Sawada M, Kikuchi R, Kojima W, Matsuda N, Yamano K: TBK1 adaptor AZI2/NAP1 regulates NDP52-driven mitochondrial autophagy. The Journal of biological chemistry. 2024.09; 300 (10): 107775. ( PubMed , DOI )

  9. Shinsei Yumoto, Haruki Horiguchi, Tsuyoshi Kadomatsu, Taichi Horino, Michio Sato, Kazutoyo Terada, Keishi Miyata, Toshiro Moroishi, Hideo Baba, Yuichi Oike: Host ANGPTL2 establishes an immunosuppressive tumor microenvironment and resistance to immune checkpoint therapy. Cancer science. 2024.09; 115 (12): 3846-3858. ( PubMed , DOI )

  10. Okano T, Ashida H, Komatsu N, Tsukasaki M, Iida T, Iwasawa M, Takahashi Y, Takeuchi Y, Iwata T, Sasai M, Yamamoto M, Takayanagi H, Suzuki T: Caspase-11 mediated inflammasome activation in macrophages by systemic infection of #IA. actinomycetemcomitans#IR exacerbates arthritis International journal of oral science. 2024.08; 16 (1): 54. ( PubMed , DOI )

  11. Akiyama M, Kanayama M, Umezawa Y, Nagao T, Izumi Y, Yamamoto M, Ohteki T: An early regulatory mechanism of hyperinflammation by restricting monocyte contribution. Frontiers in immunology. 2024.07; 15 1398153. ( PubMed , DOI )

  12. Akiyama M, Kanayama M, Umezawa Y, Nagao T, Izumi Y, Yamamoto M, Ohteki T.: An early regulatory mechanism of hyperinflammation by restricting monocyte contribution Front Immunol.. 2024.07; 15 1398153.

  13. Nam Cong-Nhat Huynh, Rui Ling, Komagamine Masatsugu, Shi Tianshu, Tsukasaki Masayuki, Matsuda Kotaro, Okamoto Kazuo, Asano Tatsuo, Muro Ryunosuke, Pluemsakunthai Warunee, Kollias George, Kaneko Yuko, Takeuchi Tsutomu, Tanaka Sakae, Komatsu Noriko, Takayanagi Hiroshi: 自己免疫性関節炎の薬物標的としてのオンコスタチンM駆動マクロファージ-線維芽細胞回路(Oncostatin M-Driven macrophage-fibroblast circuits as a drug target in autoimmune arthritis) Inflammation and Regeneration. 2024.07; 44 s41232-024. ( ichushi )

  14. Hao Li, Yohei Kanamori, Toshiro Moroishi: Cell attachment defines sensitivity to cold stress via the Hippo pathway Biochemical and Biophysical Research Communications. 2024.07; 730 150373. ( DOI )

  15. Takayuki Miyamoto, Kazushi Izawa, Sho Masui, Atsue Yamazaki, Yuichi Yamasaki, Tadashi Matsubayashi, Mayuka Shiraki, Hidenori Ohnishi, Junko Yasumura, Tomohiro Kawabe, Takako Miyamae, Tomoyo Matsubara, Naoya Arakawa, Takashi Ishige, Takumi Takizawa, Asami Shimbo, Masaki Shimizu, Naoki Kimura, Yuichi Maeda, Yuta Maruyama, Tomonari Shigemura, Junichi Furuta, Satoshi Sato, Hiroshi Tanaka, Miharu Izumikawa, Masahiro Yamamura, Toshio Hasegawa, Hiroshi Kaneko, Yasuo Nakagishi, Naoko Nakano, Yasunori Iida, Tamaki Nakamura, Hiroyuki Wakiguchi, Takayuki Hoshina, Toshinao Kawai, Kosaku Murakami, Shuji Akizuki, Akio Morinobu, Koichiro Ohmura, Katsuhide Eguchi, Motoshi Sonoda, Masataka Ishimura, Kenji Furuno, Momoko Kashiwado, Masaaki Mori, Kimito Kawahata, Koremasa Hayama, Kumiko Shimoyama, Natsuko Sasaki, Taisuke Ito, Hiroaki Umebayashi, Tae Omori, Seiko Nakamichi, Tomotsune Dohmoto, Yasuyuki Hasegawa, Hisashi Kawashima, Shojiro Watanabe, Yuichiro Taguchi, Haruna Nakaseko, Naomi Iwata, Hiroki Kohno, Taiki Ando, Yasuhiko Ito, Yuko Kataoka, Takako Saeki, Utako Kaneko, Ayako Murase, Seira Hattori, Tomo Nozawa, Kenichi Nishimura, Reiji Nakano, Misa Watanabe, Masato Yashiro, Tomonori Nakamura, Toshihiko Komai, Kentaro Kato, Yoshitaka Honda, Eitaro Hiejima, Atsushi Yonezawa, Kazuhisa Bessho, Satoshi Okada, Osamu Ohara, Junko Takita, Takahiro Yasumi, Ryuta Nishikomori, : Clinical Characteristics of Cryopyrin-Associated Periodic Syndrome and Long-Term Real-World Efficacy and Tolerability of Canakinumab in Japan: Results of a Nationwide Survey. Arthritis Rheumatol. 2024.06; 76 (6): 949-962. ( PubMed , DOI )

  16. Aiko Watanabe, Fumika Koyano, Kenichiro Imai, Yohei Hizukuri, Shizuka Ogiwara, Tomoya Ito, Jun Miyamoto, Chihiro Shibuya, Mayumi Kimura, Kazuya Toriumi, Chie Motono, Makoto Arai, Keiji Tanaka, Yoshinori Akiyama, Koji Yamano, Noriyuki Matsuda: The origin of esterase activity of Parkinson's disease causative factor DJ-1 implied by evolutionary trace analysis of its prokaryotic homolog HchA. J Biol Chem. 2024.06; 300 (7): 107476. ( PubMed , DOI )

  17. Koki Murata, Kai Harayama, Mayuko Shimoda, Mayumi Niimura, Masahiro Wakao, Yasuo Suda, Toshiro Moroishi, Hiroyuki Shinchi: Improvement of the Nuclease Resistance and Immunostimulatory Activity of CpG Oligodeoxynucleotides by Conjugation to Sugar-Immobilized Gold Nanoparticles Bioconjugate Chemistry. 2024.05; 35 (6): 804-815. ( DOI )

  18. Manabu S, Nawa N, Noguchi Y, Taki A, Kashimada A, Honda I, Koyama A, Okazaki K, Kondo M, Miyahara H, Ito K, Yamauchi T, Kondo T, Honda-Ozaki F, Kusuda S, Morioka C, Fujiwara T, Morio T, Kashimada K: Stage III Chorioamnionitis Is Associated with Reduced Risk of Severe Retinopathy of Prematurity. The Journal of pediatrics. 2024.05; 114085. ( PubMed , DOI )

  19. Nita Akihiro, Moroishi Toshiro: 細胞間情報伝達におけるHippo経路　発生と再生において判明しつつある役割(Hippo pathway in cell-cell communication: emerging roles in development and regeneration) Inflammation and Regeneration. 2024.04; 44 s41232-024. ( ichushi )

  20. Akihiro Nita, Toshiro Moroishi: Hippo pathway in cell–cell communication: emerging roles in development and regeneration Inflammation and Regeneration. 2024.04; 44 (1): ( DOI )

  21. Yamano K, Kinefuchi H, Kojima W: Mitochondrial lipid dynamics regulated by MITOL-mediated ubiquitination. Journal of biochemistry. 2024.03; 175 (3): 217-219. ( PubMed , DOI )

  22. Haruki Horiguchi, Tsuyoshi Kadomatsu, Tomoya Yamashita, Shinsei Yumoto, Taichi Horino, Michio Sato, Kazutoyo Terada, Keishi Miyata, Yuki Ichigozaki, Toshihiro Kimura, Satoshi Fukushima, Toshiro Moroishi, Yuichi Oike: Tumor stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy. Cancer Gene Therapy. 2024.03; 31 (6): 933-940. ( PubMed , DOI )

  23. The neutrophil-osteogenic cell axis promotes bone destruction in periodontitis. 2024.02; 16 (1): 18. ( PubMed , DOI )

  24. Kamii Y, Hayashizaki K, Kanno T, Chiba A, Ikegami T, Saito M, Akeda Y, Ohteki T, Kubo M, Yoshida K, Kawakami K, Oishi K, Araya J, Kuwano K, Kronenberg M, Endo Y, Kinjo Y.: IL-27 regulates the differentiation of follicular helper NKT cells via metabolic adaptation of mitochondria. Proc Natl Acad Sci USA.. 2024.02; 121 e2313964121.

  25. Ohara D, Takeuchi Y, Watanabe H, Lee Y, Mukoyama H, Ohteki T, Kondoh G, Hirota K.: Notch2 with retinoic acid license IL-23 expression by intestinal EpCAM+ DCIR2+ cDC2s in mice J Exp Med.. 2024.02; 221 e20230923.

  26. Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice. 2024.01; ( PubMed , DOI )

  27. Cui M, Yamano K, Yamamoto K, Yamamoto-Imoto H, Minami S, Yamamoto T, Matsui S, Kaminishi T, Shima T, Ogura M, Tsuchiya M, Nishino K, Layden BT, Kato H, Ogawa H, Oki S, Okada Y, Isaka Y, Kosako H, Matsuda N, Yoshimori T, Nakamura S: HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence. Proceedings of the National Academy of Sciences of the United States of America. 2024.01; 121 (2): e2306454120. ( PubMed , DOI )

  28. Yamano K, Sawada M, Kikuchi R, Nagataki K, Kojima W, Endo R, Kinefuchi H, Sugihara A, Fujino T, Watanabe A, Tanaka K, Hayashi G, Murakami H, Matsuda N: Optineurin provides a mitophagy contact site for TBK1 activation. The EMBO journal. 2024.01; 43 (5): 754-779. ( PubMed , DOI )

  29. Kawasaki I, Sugiura K, Sasaki T, Matsuda N, Sato M, Sato K: MARC-3, a membrane-associated ubiquitin ligase, is required for fast polyspermy block in Caenorhabditis elegans. Nature communications. 2024.01; 15 (1): 792. ( PubMed , DOI )

  1. Yamano K, Kinefuchi H, Kojima W: Mitochondrial quality control via organelle and protein degradation. Journal of biochemistry. 2023.12; ( PubMed , DOI )

  2. Hinokuma Hironori, Kanamori Yohei, Ikeda Koei, Hao Li, Maruno Masataka, Yamane Taishi, Maeda Ayato, Nita Akihiro, Shimoda Mayuko, Niimura Mayumi, Takeshima Yuki, Li Shuran, Suzuki Makoto, Moroishi Toshiro: 肺癌細胞増殖における第一鉄と第二鉄で異なる機能(Distinct functions between ferrous and ferric iron in lung cancer cell growth) Cancer Science. 2023.11; 114 (11): 4355-4364. ( ichushi )

  3. Effect of JAK inhibitors on the three forms of bone damage in autoimmune arthritis: joint erosion, periarticular osteopenia, and systemic bone loss. 2023.09; 43 (1): 44. ( PubMed , DOI )

  4. Shinya Abe, Takuma Asahi, Takahiro Hara, Guangwei Cui, Akihiro Shimba, Shizue Tani-Ichi, Kohei Yamada, Kazuko Miyazaki, Hitoshi Miyachi, Satsuki Kitano, Naotoshi Nakamura, Junichi Kikuta, Alexis Vandenbon, Masaki Miyazaki, Ryo Yamada, Toshiaki Ohteki, Masaru Ishii, Veronika Sexl, Takashi Nagasawa, Koichi Ikuta: Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow. Cell Rep. 2023.09; 42 (9): 113127. ( PubMed , DOI )

  5. Komagamine Masatsugu, Komatsu Noriko, Ling Rui, Okamoto Kazuo, Tianshu Shi, Matsuda Kotaro, Takeuchi Tsutomu, Kaneko Yuko, Takayanagi Hiroshi: 自己免疫性関節炎においてJAK阻害剤が3種類の骨損傷病変に及ぼす影響　関節びらん、関節周囲の骨減少、全身の骨喪失(Effect of JAK inhibitors on the three forms of bone damage in autoimmune arthritis: joint erosion, periarticular osteopenia, and systemic bone loss) Inflammation and Regeneration. 2023.09; 43 1 of 14-14 of 14. ( ichushi )

  6. Hironori Hinokuma, Yohei Kanamori, Koei Ikeda, Li Hao, Masataka Maruno, Taishi Yamane, Ayato Maeda, Akihiro Nita, Mayuko Shimoda, Mayumi Niimura, Yuki Takeshima, Shuran Li, Makoto Suzuki, Toshiro Moroishi: Distinct functions between ferrous and ferric iron in lung cancer cell growth. Cancer science. 2023.09; 114 (11): 4355-4364. ( PubMed , DOI )

  7. Kurusu R, Fujimoto Y, Morishita H, Noshiro D, Takada S, Yamano K, Tanaka H, Arai R, Kageyama S, Funakoshi T, Komatsu-Hirota S, Taka H, Kazuno S, Miura Y, Koike M, Wakai T, Waguri S, Noda NN, Komatsu M: Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex. Developmental cell. 2023.07; 58 (13): 1189-1205.e11. ( PubMed , DOI )

  8. Akari Nakamura, Seiichiro Sakai, Yoshitaka Taketomi, Jun Tsuyama, Yoshimi Miki, Yuichiro Hara, Nobutaka Arai, Yuki Sugiura, Hideya Kawaji, Makoto Murakami, Takashi Shichita: PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke. Neuron. 2023.07; 111 (19): 2995-+. ( PubMed , DOI )

  9. Ziegler-Heitbrock L, Ohteki T, Ginhoux F, Shortman K, Spits H.: Reply to 'Reclassifying plasmacytoid dendritic cells as innate lymphocytes is premature'. Nat Rev Immunol. 2023.05; 23 (5): 338-339.

  10. Seiichiro Sakai, Takashi Shichita: Role of alarmins in poststroke inflammation and neuronal repair. Semin Immunopathol. 2023.05; 45 (3): 427-435. ( PubMed , DOI )

  11. Akabane S, Watanabe K, Kosako H, Yamashita SI, Nishino K, Kato M, Sekine S, Kanki T, Matsuda N, Endo T, Oka T: TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria. Cell reports. 2023.05; 42 (5): 112454. ( PubMed , DOI )

  12. Masashi Kanayama, Yuta Izumi, Megumi Akiyama, Toyoki Hayashi, Koji Atarashi, Axel Roers, Taku Sato, Toshiaki Ohteki: Myeloid-like B cells boost emergency myelopoiesis through IL-10 production during infection. J Exp Med. 2023.04; 220 (4): e20221221. ( PubMed , DOI )

  13. Yamano K, Sawada M, Kikuchi R, Nagataki K, Kojima W, Sugihara A, Fujino T, Tanaka K, Hayashi G, Murakami H, Matsuda N. : Optineurin provides a mitophagy contact site for TBK1 activation bioRxiv. 2023.02;

  14. Hayashida R, Kikuchi R, Imai K, Kojima W, Yamada T, Iijima M, Sesaki H, Tanaka K, Matsuda N, Yamano K: Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid-liquid phase separation-based method. The Journal of biological chemistry. 2023.02; 299 (2): 102822. ( PubMed , DOI )

  1. Bu Luke, Yonemura Atsuko, Yasuda-Yoshihara Noriko, Uchihara Tomoyuki, Ismagulov Galym, Takasugi Sanae, Yasuda Tadahito, Okamoto Yuya, Kitamura Fumimasa, Akiyama Takahiko, Arima Kota, Itoyama Rumi, Zhang Jun, Fu Lingfeng, Hu Xichen, Wei Feng, Arima Yuichiro, Moroishi Toshiro, Nishiyama Koichi, Sheng Guojun, Mukunoki Toshifumi, Otani Jun, Baba Hideo, Ishimoto Takatsugu: 腫瘍微小環境における15-PGDHの枯渇は膵臓癌における線維性腫瘍形成と血管新生を促進する(Tumor microenvironmental 15-PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer) Cancer Science. 2022.10; 113 (10): 3579-3592. ( ichushi )

  2. Guangwei Cui, Akihiro Shimba, Jianshi Jin, Taisaku Ogawa, Yukiko Muramoto, Hitoshi Miyachi, Shinya Abe, Takuma Asahi, Shizue Tani-Ichi, Johannes M Dijkstra, Yayoi Iwamoto, Kirill Kryukov, Yuanbo Zhu, Daichi Takami, Takahiro Hara, Satsuki Kitano, Yan Xu, Hajime Morita, Moyu Zhang, Lynn Zreka, Keishi Miyata, Takashi Kanaya, Shinya Okumura, Takashi Ito, Etsuro Hatano, Yoshimasa Takahashi, Hiroshi Watarai, Yuichi Oike, Tadashi Imanishi, Hiroshi Ohno, Toshiaki Ohteki, Nagahiro Minato, Masato Kubo, Georg A Holländer, Hideki Ueno, Takeshi Noda, Katsuyuki Shiroguchi, Koichi Ikuta: A circulating subset of iNKT cells mediates antitumor and antiviral immunity. Sci Immunol. 2022.10; 7 (76): eabj8760. ( PubMed , DOI )

  3. Loems Ziegler-Heitbrock, Toshiaki Ohteki, Florent Ginhoux, Ken Shortman, Hergen Spits: Reclassifying plasmacytoid dendritic cells as innate lymphocytes. Nat Rev Immunol. 2022.10; 23 (1): 1-2. ( PubMed , DOI )

  4. Taishi Yamane, Yohei Kanamori, Hiroshi Sawayama, Hiromu Yano, Akihiro Nita, Yudai Ohta, Hironori Hinokuma, Ayato Maeda, Akiko Iwai, Takashi Matsumoto, Mayuko Shimoda, Mayumi Niimura, Shingo Usuki, Noriko Yasuda-Yoshihara, Masato Niwa, Yoshifumi Baba, Takatsugu Ishimoto, Yoshihiro Komohara, Tomohiro Sawa, Tasuku Hirayama, Hideo Baba, Toshiro Moroishi: Iron accelerates Fusobacterium nucleatum-induced CCL8 expression in macrophages and is associated with colorectal cancer progression JCI Insight. 2022.09; 7 (21): ( PubMed , DOI )

  5. Mechanisms of joint destruction in rheumatoid arthritis - immune cell-fibroblast-bone interactions. 2022.07; 18 (7): 415-429. ( PubMed , DOI )

  6. Sonn I, Honda-Ozaki F, Yoshimatsu S, Morimoto S, Watanabe H, Okano H: Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia. Inflammation and regeneration. 2022.07; 42 (1): 20. ( PubMed , DOI )

  7. Haruki Horiguchi, Tsuyoshi Kadomatsu, Shinsei Yumoto, Takeshi Masuda, Keishi Miyata, Shuji Yamamura, Michio Sato, Jun Morinaga, Sumio Ohtsuki, Hideo Baba, Toshiro Moroishi, Yuichi Oike: Tumor cell-derived ANGPTL2 promotes β-catenin-driven intestinal tumorigenesis Oncogene. 2022.07; 41 (33): 4028-4041. ( PubMed , DOI )

  8. Luke Bu, Atsuko Yonemura, N. Yasuda‐Yoshihara, Tomoyuki Uchihara, Galym Ismagulov, Sanae Takasugi, Tadahito Yasuda, Yuya Okamoto, Fumimasa Kitamura, Takahiko Akiyama, Kota Arima, Rumi Itoyama, Jun Zhang, Lingfeng Fu, Xichen Hu, Feng Wei, Yuichiro Arima, Toshiro Moroishi, Koichi Nishiyama, Guojun Sheng, Toshifumi Mukunoki, Jun Otani, Hideo Baba, Takatsugu Ishimoto: Tumor microenvironmental 15‐PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer Cancer Science. 2022.07; 113 (10): 3579-3592. ( PubMed , DOI )

  9. Masayuki Tsukasaki, Noriko Komatsu, Takako Negishi-Koga, Nam Cong-Nhat Huynh, Ryunosuke Muro, Yutaro Ando, Yuka Seki, Asuka Terashima, Warunee Pluemsakunthai, Takeshi Nitta, Takashi Nakamura, Tomoki Nakashima, Shinsuke Ohba, Haruhiko Akiyama, Kazuo Okamoto, Roland Baron, Hiroshi Takayanagi: Periosteal stem cells control growth plate stem cells during postnatal skeletal growth. Nat Commun. 2022.07; 13 (1): 4166. ( PubMed , DOI )

  10. Sonn Iki, Honda-Ozaki Fumiko, Yoshimatsu Sho, Morimoto Satoru, Watanabe Hirotaka, Okano Hideyuki: 一つの転写因子が高い効率でヒト人工多能性幹細胞を機能性ミクログリアに誘導する(Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia) Inflammation and Regeneration. 2022.06; 42 1 of 20-20 of 20. ( ichushi )

  11. Fuentes, I; Morishita, Y; Gonzalez-Salinas, S; Champagne, FA; Uchida, S; Shumyatsky, GP: Experience-Regulated Neuronal Signaling in Maternal Behavior FRONTIERS IN MOLECULAR NEUROSCIENCE. 2022.03; 15 844295. ( PubMed , DOI )

  12. Hiroyuki Shinchi, Fumikazu Komaki, Masaharu Yuki, Haruka Ohara, Naohiro Hayakawa, Masahiro Wakao, Howard B. Cottam, Tomoko Hayashi, Dennis A. Carson, Toshiro Moroishi, Yasuo Suda: Glyco-Nanoadjuvants: Impact of Linker Length for Conjugating a Synthetic Small-Molecule TLR7 Ligand to Glyco-Nanoparticles on Immunostimulatory Effects ACS Chemical Biology. 2022.03; 17 (4): 957-968. ( DOI )

  13. Daichi Nomoto, Yoshifumi Baba, Yang Liu, Hiroyasu Tsutsuki, Kazuo Okadome, Kazuto Harada, Takatsugu Ishimoto, Masaaki Iwatsuki, Shiro Iwagami, Yuji Miyamoto, Naoya Yoshida, Masayuki Watanabe, Toshiro Moroishi, Yoshihiro Komohara, Tomohiro Sawa, Hideo Baba: Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression via the NOD1/RIPK2/NF-κB pathway Cancer Letters. 2022.01; 530 59-67. ( PubMed , DOI )

  14. Le Yu, Dan Zhou, Guiming Zhang, Zhonglu Ren, Xin Luo, Peng Liu, Steven W. Plouffe, Zhipeng Meng, Toshiro Moroishi, Yilei Li, Yiyue Zhang, Joan Heller Brown, Shuwen Liu, Kun‐Liang Guan: Co‐occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence Molecular Oncology. 2022; 16 (3): 607-629. ( DOI )

  1. Adachi A, Honda T, Dainichi T, Egawa G, Yamamoto Y, Nomura T, Nakajima S, Otsuka A, Maekawa M, Mano N, Koyanagi N, Kawaguchi Y, Ohteki T, Nagasawa T, Ikuta K, Kitoh A, Kabashima K.: Prolonged high-intensity exercise induces fluctuating immune responses to herpes simplex virus infection via glucocorticoids. J Allergy Clin Immunol. 2021.12;

  2. Bruno Barros Queliconi, Waka Kojima, Mayumi Kimura, Kenichiro Imai, Chisato Udagawa, Chie Motono, Takatsugu Hirokawa, Shinya Tashiro, Jose M M Caaveiro, Kouhei Tsumoto, Koji Yamano, Keiji Tanaka, Noriyuki Matsuda: Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-1. J Cell Sci. 2021.11; 134 (22): jcs258653. ( PubMed , DOI )

  3. Ohteki T, Kawamura S, Onai N.: Commitment to dendritic cells and monocytes. Int Immunol.. 2021.11;

  4. Seki, T; Yamagata, H; Uchida, S; Kobayashi, A; Watanabe, Y; Nakagawa, S: A novel mouse model of postpartum depression using emotional stress as evaluated by nesting behavior SCIENTIFIC REPORTS. 2021.11; 11 (1): 22615. ( PubMed , DOI )

  5. Yamano K, Kojima W: Molecular functions of autophagy adaptors upon ubiquitin-driven mitophagy. Biochimica et biophysica acta. General subjects. 2021.10; 1865 (10): 129972. ( PubMed , DOI )

  6. Kawatake-Kuno, A; Murai, T; Uchida, S: A Multiscale View of the Mechanisms Underlying Ketamine's Antidepressant Effects: An Update on Neuronal Calcium Signaling FRONTIERS IN BEHAVIORAL NEUROSCIENCE. 2021.09; 15 749180. ( PubMed , DOI )

  7. Waka Kojima, Koji Yamano, Hidetaka Kosako, Kenichiro Imai, Reika Kikuchi, Keiji Tanaka, Noriyuki Matsuda: Mammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy. Autophagy. 2021.08; 17 (8): 2011-2036. ( PubMed , DOI )

  8. Yukiko Yoshida, Makoto Asahina, Arisa Murakami, Junko Kawawaki, Meari Yoshida, Reiko Fujinawa, Kazuhiro Iwai, Ryuichi Tozawa, Noriyuki Matsuda, Keiji Tanaka, Tadashi Suzuki: Loss of peptide N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase. Proc Natl Acad Sci U S A. 2021.07; 118 (27): e2102902118. ( PubMed , DOI )

  9. Taiki Baba, Susumu Tanimura, Ayane Yamaguchi, Koichiro Horikawa, Masashi Yokozeki, Saki Hachiya, Shun-Ichiro Iemura, Tohru Natsume, Noriyuki Matsuda, Kohsuke Takeda: Cleaved PGAM5 dephosphorylates nuclear serine/arginine-rich proteins during mitophagy. Biochim Biophys Acta Mol Cell Res. 2021.07; 1868 (7): 119045. ( PubMed , DOI )

  10. Kawatake-Kuno, A; Murai, T; Uchida, S: The Molecular Basis of Depression: Implications of Sex-Related Differences in Epigenetic Regulation FRONTIERS IN MOLECULAR NEUROSCIENCE. 2021.07; 14 708004. ( PubMed , DOI )

  11. Toshiro Moroishi: ANXious for YAP Nature Chemical Biology. 2021.07; 17 (7): 750-751. ( DOI )

  12. Sakai, Y; Li, HY; Inaba, H; Funayama, Y; Ishimori, E; Kawatake-Kuno, A; Yamagata, H; Seki, T; Hobara, T; Nakagawa, S; Watanabe, Y; Tomita, S; Murai, T; Uchida, S: Gene-environment interactions mediate stress susceptibility and resilience through the CaMKIIβ/TARPγ-8/AMPAR pathway ISCIENCE. 2021.05; 24 (5): 102504. ( PubMed , DOI )

  13. Koutarou Nakamura, Seiichiro Sakai, Jun Tsuyama, Akari Nakamura, Kento Otani, Kumiko Kurabayashi, Yoshiko Yogiashi, Hisao Masai, Takashi Shichita: Extracellular DJ-1 induces sterile inflammation in the ischemic brain. PLoS Biol. 2021.05; 19 (5): e3000939. ( PubMed , DOI )

  14. Noriko Komatsu, Stephanie Win, Minglu Yan, Nam Cong-Nhat Huynh, Shinichiro Sawa, Masayuki Tsukasaki, Asuka Terashima, Warunee Pluemsakunthai, George Kollias, Tomoki Nakashima, Hiroshi Takayanagi: Plasma cells promote osteoclastogenesis and periarticular bone loss in autoimmune arthritis. J Clin Invest. 2021.03; 131 (6): ( PubMed , DOI )

  15. Kase, N; Terashima, M; Ohta, A; Niwa, A; Honda-Ozaki, F; Kawasaki, Y; Nakahata, T; Kanazawa, N; Saito, MK: Pluripotent stem cell-based screening identifiesCUDC-907 as an effective compound for restoring the in vitro phenotype ofNakajo-Nishimurasyndrome STEM CELLS TRANSLATIONAL MEDICINE. 2021.03; 10 (3): 455-464. ( PubMed , DOI )

  16. Hiroyuki Shinchi, Masaharu Yuki, Takayoshi Yamauchi, Mayumi Niimura, Masahiro Wakao, Howard B. Cottam, Tomoko Hayashi, Dennis A. Carson, Toshiro Moroishi, Yasuo Suda: Glyco-Nanoadjuvants: Sugar Structures on Carriers of a Small Molecule TLR7 Ligand Affect Their Immunostimulatory Activities ACS Applied Bio Materials. 2021.03; 4 (3): 2732-2741. ( DOI )

  17. Chikuma S, Yamanaka S, Nakagawa S, Ueda MT, Hayabuchi H, Tokifuji Y, Kanayama M, Okamura T, Arase H, Yoshimura A: TRIM28 Expression on Dendritic Cells Prevents Excessive T Cell Priming by Silencing Endogenous Retrovirus. Journal of immunology (Baltimore, Md. : 1950). 2021.02; 206 (7): 1528-1539. ( PubMed , DOI )

  18. Izumi Y, Kanayama M, Shen Z, Kai M, Kawamura S, Akiyama M, Yamamoto M, Nagao T, Okada K, Kawamata N, Toyota S, Ohteki T: An Antibody-Drug Conjugate That Selectively Targets Human Monocyte Progenitors for Anti-Cancer Therapy. Frontiers in immunology. 2021.02; 12 618081. ( PubMed , DOI )

  19. Mashun Onishi, Koji Yamano, Miyuki Sato, Noriyuki Matsuda, Koji Okamoto: Molecular mechanisms and physiological functions of mitophagy. EMBO J. 2021.02; 40 (3): e104705. ( PubMed , DOI )

  20. Yamauchi Takayoshi, Moroishi Toshiro: 腫瘍免疫における腫瘍由来細胞外小胞の陰と陽(【Medical chemistry of extracellular vesicles】The Yin and Yang of tumour-derived extracellular vesicles in tumour immunity) The Journal of Biochemistry. 2021.02; 169 (2): 155-161. ( ichushi )

  21. Izumi Y, Kanayama M, Shen Z, Kai M, Kawamura S, Akiyama M, Yamamoto M, Nagao T, Okada K, Kawamata N, Toyota S, Ohteki T.: An Antibody-Drug Conjugate That Selectively Targets Human Monocyte Progenitors for Anti-Cancer Therapy. Front Immunol.. 2021.02; 12 618081..

  22. Yamagata, H; Ogihara, H; Matsuo, K; Uchida, S; Kobayashi, A; Seki, T; Kobayashi, M; Harada, K; Chen, C; Miyata, S; Fukuda, M; Mikuni, M; Hamamoto, Y; Watanabe, Y; Nakagawa, S: Distinct epigenetic signatures between adult-onset and late-onset depression SCIENTIFIC REPORTS. 2021.01; 11 (1): 2296. ( PubMed , DOI )

  23. Takayoshi Yamauchi, Toshiro Moroishi: The Yin and Yang of tumour-derived extracellular vesicles in tumour immunity The Journal of Biochemistry. 2021; 169 (2): 155-161. ( DOI )

  1. Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution. 2020.12; 2 (12): 1382-1390. ( PubMed , DOI )

  2. Min Luo, Zhipeng Meng, Toshiro Moroishi, Kimberly C. Lin, Guobo Shen, Fei Mo, Bin Shao, Xiawei Wei, Ping Zhang, Yuquan Wei, Kun-Liang Guan: Heat stress activates YAP/TAZ to induce the heat shock transcriptome Nature Cell Biology. 2020.12; 22 (12): 1447-1459. ( DOI )

  3. Yamano K, Youle RJ: Two different axes CALCOCO2-RB1CC1 and OPTN-ATG9A initiate PRKN-mediated mitophagy. Autophagy. 2020.11; 16 (11): 2105-2107. ( PubMed , DOI )

  4. Haruki Horiguchi, Tsuyoshi Kadomatsu, Keishi Miyata, Kazutoyo Terada, Michio Sato, Daisuke Torigoe, Jun Morinaga, Toshiro Moroishi, Yuichi Oike: Stroma-derived ANGPTL2 establishes an anti-tumor microenvironment during intestinal tumorigenesis Oncogene. 2020.10; ( DOI )

  5. Matsuda N, Yamano K: Two sides of a coin: Physiological significance and molecular mechanisms for damage-induced mitochondrial localization of PINK1 and Parkin. Neuroscience research. 2020.10; 159 16-24. ( PubMed , DOI )

  6. Kana Minamide, Taku Sato, Yusuke Nakanishi, Hiroshi Ohno, Tamotsu Kato, Jumpei Asano, Toshiaki Ohteki: IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon. Sci Rep. 2020.09; 10 (1): 14639. ( PubMed , DOI )

  7. OPG Production Matters Where It Happened. 2020.09; 32 (10): 108124. ( PubMed , DOI )

  8. Kanayama M, Izumi Y, Yamauchi Y, Kuroda S, Shin T, Ishikawa S, Sato T, Kajita M, Ohteki T.: CD86-based analysis enables observation of bona fide hematopoietic responses Blood.. 2020.09; 136 (10): 1144-1154.

  9. Koji Yamano, Reika Kikuchi, Waka Kojima, Ryota Hayashida, Fumika Koyano, Junko Kawawaki, Takuji Shoda, Yosuke Demizu, Mikihiko Naito, Keiji Tanaka, Noriyuki Matsuda: Critical role of mitochondrial ubiquitination and the OPTN ATG9A axis in mitophagy Journal of Cell Biology. 2020.09; 219 (9): ( PubMed , DOI )

  10. Yamano K, Kikuchi R, Kojima W, Hayashida R, Koyano F, Kawawaki J, Shoda T, Demizu Y, Naito M, Tanaka K, Matsuda N: Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy. The Journal of cell biology. 2020.09; 219 (9): ( PubMed , DOI )

  11. Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells. 2020.08; 58 102913. ( PubMed , DOI )

  12. Sato T, Ishikawa S, Asano J, Yamamoto H, Fujii M, Sato T, Yamamoto K, Kitagaki K, Akashi T, Okamoto R, Ohteki T.: Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages. Nat Cell Biol. . 2020.08; 22 (8): 919-926.

  13. Liang J, Zhang JJ, Huang HI, Kanayama M, Youssef N, Jin YJ, Reyes EY, Abram CL, Yang S, Lowell CA, Wang D, Shao L, Shinohara ML, Zhang JY, Hammer GE: The ubiquitin-modifying enzyme A20 terminates C-type lectin receptor signals and is a suppressor of host defense against systemic fungal infection. Infection and immunity. 2020.06; 88 (9): ( PubMed , DOI )

  14. T cells in the regulation of bone metabolism 2020.06; 12-19.

  15. Kanayama M, Izumi Y, Yamauchi Y, Kuroda S, Shin T, Ishikawa S, Sato T, Kajita M, Ohteki T: CD86-based analysis enables observation of bona fide hematopoietic responses. Blood. 2020.05; ( PubMed , DOI )

  16. Taku Sato, Miwako Sase, Shun Ishikawa, Mihoko Kajita, Jumpei Asano, Toshiro Sato, Yoshiyuki Mori, Toshiaki Ohteki: Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine. Sci Rep. 2020.05; 10 (1): 8308. ( PubMed , DOI )

  17. 泉 湧太, 金山 剛士, 秋山 めぐみ, 甲斐 正之, 沈 鐘楚子, 川又 紀彦, 樗木 俊聡: Targeting monocyte lineage-restricted antigen as a novel therapeutic strategy for monocytic leukemia(和訳中) 日本病理学会会誌. 2020.03; 109 (1): 304. ( ichushi )

  18. Shimoda Mayuko, Moroishi Toshiro: Hippo pathwayとノンコーディングRNAとの新たなリンク(The Emerging Link between the Hippo Pathway and Non-coding RNA) Biological & Pharmaceutical Bulletin. 2020.01; 43 (1): 1-10. ( ichushi )

  19. Jumpei Asano, Taku Sato, Toshiaki Ohteki: Autophagy Detection in Intestinal Stem Cells. Methods Mol Biol. 2020; 2171 115-125. ( PubMed , DOI )

  1. Uchida, S: Epigenetic Mechanisms of Stress Susceptibility and Resilience NEUROPSYCHOPHARMACOLOGY. 2019.12; 44 (SUPPL 1): 116.

  2. Koyano F, Yamano K, Kosako H, Kimura Y, Kimura M, Fujiki Y, Tanaka K, Matsuda N: Parkin-mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes. EMBO reports. 2019.12; 20 (12): e47728. ( PubMed , DOI )

  3. Spotlight on early-career researchers: an interview with Toshiro Moroishi 2019.12; 2 (1): ( DOI )

  4. Haruki Horiguchi, Tsuyoshi Kadomatsu, Ryoma Kurahashi, Chiaki Hara, Keishi Miyata, Masaya Baba, Hironobu Osumi, Kazutoyo Terada, Kimi Araki, Toshiyuki Takai, Tomomi Kamba, W Marston Linehan, Toshiro Moroishi, Yuichi Oike: Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity. Genes & development. 2019.12; 33 (23-24): 1641-1656. ( PubMed , DOI )

  5. Kanayama Masashi, Izumi Yuta, Ohteki Toshiaki: Hematopoiesis and Immune Environment　Analysis with an alternative marker for Sca-1 revealed bona fide hematopoietic responses during infection(和訳中) 日本免疫学会総会・学術集会記録. 2019.11; 48 (Proceedings): 1-H. ( ichushi )

  6. Seiichiro Sakai, Takashi Shichita: Inflammation and neural repair after ischemic brain injury. Neurochem Int. 2019.11; 130 104316. ( PubMed , DOI )

  7. Beneficial effect of methotrexate on a child case of Nakajo-Nishimura syndrome. 2019.10; 46 (10): e365-e367. ( PubMed , DOI )

  8. Kunimoto Kayo, Honda-Ozaki Fumiko, Saito Megumu K., Furukawa Fukumi, Kanazawa Nobuo: 中條・西村症候群の小児症例に対するメトトレキサートの有益な作用(Beneficial effect of methotrexate on a child case of Nakajo-Nishimura syndrome) The Journal of Dermatology. 2019.10; 46 (10): e365-e367. ( ichushi )

  9. Seki, T; Yamagata, H; Uchida, S; Chen, C; Kobayashi, A; Kobayashi, M; Harada, K; Matsuo, K; Watanabe, Y; Nakagawa, S: Altered expression of long noncoding RNAs in patients with major depressive disorder JOURNAL OF PSYCHIATRIC RESEARCH. 2019.10; 117 92-99. ( PubMed , DOI )

  10. Shinchi, H, Yamaguchi, T, Moroishi, T, Yuki, M, Wakao, M, Hayashi, T, Cottam, H.B, Carson, D.A, Suda, Y: Gold nanoparticles co-immobilized with small molecule toll-like receptor 7 ligand and α-mannose as adjuvants Bioconjugate Chem.. 2019.10; 30 (11): 2811-2821. ( DOI )

  11. Hiroyuki Tezuka, Toshiaki Ohteki: Regulation of IgA Production by Intestinal Dendritic Cells and Related Cells. Front Immunol. 2019.08; 10 1891. ( PubMed , DOI )

  12. Koyano F, Yamano K, Kosako H, Tanaka K, Matsuda N: Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL. The Journal of biological chemistry. 2019.06; 294 (26): 10300-10314. ( PubMed , DOI )

  13. Kanazawa Nobuo, Honda-Ozaki Fumiko, Saito Megumu K.: 中條-西村症候群を再現した人工多能性幹細胞(Induced pluripotent stem cells representing Nakajo-Nishimura syndrome) Inflammation and Regeneration. 2019.05; 39 1 of 8-8 of 8. ( ichushi )

  14. Muto Y, Moroishi T, Ichihara K, Nishiyama M, Shimizu H, Eguchi H, Moriya K, Koike K, Mimori K, Mori M, Katayama Y, Nakayama KI: Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis Journal of Experimental Medicine. 2019.04; 216 (4): 950-965. ( PubMed , DOI )

  15. Takayoshi Yamauchi, Toshiro Moroishi: Hippo Pathway in Mammalian Adaptive Immune System Cells. 2019.04; 8 (5): 398. ( DOI )

  16. Sachin Verma, Narayana Yeddula, Yasushi Soda, Quan Zhu, Gerald Pao, James Moresco, Jolene K. Diedrich, Audrey Hong, Steve Plouffe, Toshiro Moroishi, Kun-Liang Guan, Inder M. Verma: BRCA1/BARD1-dependent ubiquitination of NF2 regulates Hippo-YAP1 signaling Proceedings of the National Academy of Sciences. 2019.04; 116 (15): 7363-7370. ( DOI )

  17. Zi Wang, Soichiro Adachi, Lingling Kong, Daisuke Watanabe, Yusuke Nakanishi, Toshiaki Ohteki, Namiko Hoshi, Yuzo Kodama: Role of eosinophils in a murine model of inflammatory bowel disease. Biochem. Biophys. Res. Commun.. 2019.03; 511 (1): 99-104. ( PubMed , DOI )

  18. Ei Ei Mon , Wei Fan-Yan, Ahmad Raja Norazireen Raja, Yamamoto Takahiro, Moroishi Toshiro, Tomizawa Kazuhito: sideroflexin 2によるミトコンドリアでの鉄恒常性の制御(Regulation of mitochondrial iron homeostasis by sideroflexin 2) The Journal of Physiological Sciences. 2019.03; 69 (2): 359-373. ( ichushi )

  19. Mon, E.E, Wei, F.Y, Ahmad, R.N.R, Yamamoto, T, Moroishi, T, Tomizawa, K: Regulation of mitochondrial iron homeostasis by sideroflexin 2. J. Physiol. Sci.. 2019.03; 69 (2): 359-373. ( PubMed , DOI )

  20. Takahashi, M; Izawa, K; Urai, M; Yamanishi, Y; Maehara, A; Isobe, M; Matsukawa, T; Kaitani, A; Takamori, A; Uchida, S; Yamada, H; Nagamine, M; Ando, T; Shimizu, T; Ogawa, H; Okumura, K; Kinjo, Y; Kitamura, T; Kitaura, J: The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide-dependent neutrophil recruitment SCIENCE SIGNALING. 2019.01; 12 (564): ( PubMed , DOI )

  21. Yamaguchi Ayane, Ishikawa Hayate, Furuoka Mana, Yokozeki Masashi, Matsuda Noriyuki, Tanimura Susumu, Takeda Kohsuke: 切断型PGAM5はマイトファジー中のミトコンドリア外膜のプロテオソーム介在性断裂に応じてミトコンドリアから放出される(Cleaved PGAM5 is released from mitochondria depending on proteasome-mediated rupture of the outer mitochondrial membrane during mitophagy) The Journal of Biochemistry. 2019.01; 165 (1): 19-25. ( ichushi )

  22. Yamaguchi A, Ishikawa H, Furuoka M, Yokozeki M, Matsuda N, Tanimura S, Takeda K: Cleaved PGAM5 is released from mitochondria depending on proteasome-mediated rupture of the outer mitochondrial membrane during mitophagy. Journal of biochemistry. 2019.01; 165 (1): 19-25. ( PubMed , DOI )

  23. Induced pluripotent stem cells representing Nakajo-Nishimura syndrome. 2019; 39 11. ( PubMed , DOI )

  24. Adachi Takahiro, Yoshikawa Soichiro, Tezuka Hiroyuki, Tsuji Noriko M., Ohteki Toshiaki, Karasuyama Hajime, Kumazawa Toshihiko: Propolis induces Ca2+ signaling in immune cells BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH. 2019; 38 (4): 141-149. ( DOI )

  1. Immune-bone interplay in the structural damage in rheumatoid arthritis. 2018.10; 194 (1): 1-8. ( PubMed , DOI )

  2. Yamano K, Lazarou M: YoungMito 2018: Report on the 1st International Mitochondria Meeting for Young Scientists. Genes to cells : devoted to molecular & cellular mechanisms. 2018.10; 23 (10): 822-827. ( PubMed , DOI )

  3. Shunsuke Kawamura, Toshiaki Ohteki: Monopoiesis in humans and mice. Int. Immunol.. 2018.10; 30 (11): 503-509. ( PubMed , DOI )

  4. Taisuke Yoneda, Seiichiro Sakai, Hisato Maruoka, Toshihiko Hosoya: Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex. J Vis Exp. 2018.09; (139): ( PubMed , DOI )

  5. Tashiro S, Caaveiro JMM, Nakakido M, Tanabe A, Nagatoishi S, Tamura Y, Matsuda N, Liu D, Hoang QQ, Tsumoto K: Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1. ACS chemical biology. 2018.09; 13 (9): 2783-2793. ( PubMed , DOI )

  6. RAP2 mediates mechanoresponses of the Hippo pathway 2018.08; 560 (7720): 655-660. ( DOI )

  7. Uchida, S; Shumyatsky, GP: Epigenetic regulation of Fgf1 transcription by CRTC1 and memory enhancement BRAIN RESEARCH BULLETIN. 2018.07; 141 3-12. ( PubMed , DOI )

  8. Okatsu K, Sato Y, Yamano K, Matsuda N, Negishi L, Takahashi A, Yamagata A, Goto-Ito S, Mishima M, Ito Y, Oka T, Tanaka K, Fukai S: Structural insights into ubiquitin phosphorylation by PINK1. Scientific reports. 2018.07; 8 (1): 10382. ( PubMed , DOI )

  9. Daniel Martin, Maria S. Degese, Lynn Vitale-Cross, Ramiro Iglesias-Bartolome, Juan Luis Callejas Valera, Zhiyong Wang, Xiaodong Feng, Huwate Yeerna, Vachan Vadmal, Toshiro Moroishi, Rick F. Thorne, Moraima Zaida, Bradford Siegele, Sok C. Cheong, Alfredo A. Molinolo, Yardena Samuels, Pablo Tamayo, Kun Liang Guan, Scott M. Lippman, J. Guy Lyons, J. Silvio Gutkind: Assembly and activation of the Hippo signalome by FAT1 tumor suppressor Nature Communications. 2018.07; 9 (1): 2372. ( DOI )

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  5. Keiko Danzaki, Yutaka Matsui, Masahiro Ikesue, Daichi Ohta, Koyu Ito, Masashi Kanayama, Daisuke Kurotaki, Junko Morimoto, Yoichiro Iwakura, Hideo Yagita, Hiroyuki Tsutsui, Toshimitsu Uede: Interleukin-17A deficiency accelerates unstable atherosclerotic plaque formation in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol.. 2012.02; 32 (2): 273-280. ( PubMed , DOI )

  6. Yukinori Tsukuda, Norimasa Iwasaki, Naoki Seito, Masashi Kanayama, Naoki Fujitani, Yasuro Shinohara, Yasuhiko Kasahara, Tomohiro Onodera, Koji Suzuki, Tsuyoshi Asano, Akio Minami, Tadashi Yamashita: Ganglioside GM3 has an essential role in the pathogenesis and progression of rheumatoid arthritis. PLoS ONE. 2012.01; 7 (6): e40136. ( PubMed , DOI )

  1. Masashi Kanayama, Junko Morimoto, Yutaka Matsui, Masahiro Ikesue, Keiko Danzaki, Daisuke Kurotaki, Koyu Ito, Toshimichi Yoshida, Toshimitsu Uede: α9β1 integrin-mediated signaling serves as an intrinsic regulator of pathogenic Th17 cell generation. J. Immunol.. 2011.12; 187 (11): 5851-5864. ( PubMed , DOI )

  2. Higuchi F, Uchida S, Yamagata H, Otsuki K, Hobara T, Abe N, Shibata T, Watanabe Y: State-dependent changes in the expression of DNA methyltransferases in mood disorder patients. Journal of psychiatric research. 2011.10; 45 (10): 1295-1300. ( PubMed , DOI )

  3. ストレスによる脳機能障害の分子基盤 気分障害におけるエピジェネティクス(Molecular mechanism of brain dysfunction induced by stress Epigenetic regulation in depression) 2011.10; 21回・41回 105. ( ichushi )

  4. Molecular Basis of Depression エピジェネティクスとストレス脆弱性、うつ病(Molecular Basis of Depression Epigenetic regulation of stress vulnerability and depression) 2011.09; 50 (2-3): 136. ( ichushi )

  5. Hirosato Mashima, Taku Sato, Yasuo Horie, Yuko Nakagawa, Itaru Kojima, Toshiaki Ohteki, Hirohide Ohnishi: Interferon regulatory factor-2 regulates exocytosis mechanisms mediated by SNAREs in pancreatic acinar cells. Gastroenterology. 2011.09; 141 (3): 1102-1113.e1. ( PubMed , DOI )

  6. Abe N, Uchida S, Otsuki K, Hobara T, Yamagata H, Higuchi F, Shibata T, Watanabe Y: Altered sirtuin deacetylase gene expression in patients with a mood disorder. Journal of psychiatric research. 2011.08; 45 (8): 1106-1112. ( PubMed , DOI )

  7. 樗木俊聡: 腸管粘膜における樹状細胞の役割(The Role of dendritic cells in the intestinal mucosa) 日本耳鼻咽喉科学会会報　114. 2011.06; 107-113.

  8. Development of a tightly-regulated tetracycline-dependent transcriptional activator and repressor co-expression system for the strong induction of transgene expression 2011.05; 63 (3): 211-216. ( PubMed , DOI )

  9. Hiroyuki Tezuka, Yukiko Abe, Jumpei Asano, Taku Sato, Jiajia Liu, Makoto Iwata, Toshiaki Ohteki: Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction. Immunity. 2011.02; 34 (2): 247-257. ( PubMed , DOI )

  10. Daisuke Kurotaki, Shigeyuki Kon, Kyeonghwa Bae, Koyu Ito, Yutaka Matsui, Yosuke Nakayama, Masashi Kanayama, Chiemi Kimura, Yoshinori Narita, Takashi Nishimura, Kazuya Iwabuchi, Matthias Mack, Nico van Rooijen, Shimon Sakaguchi, Toshimitsu Uede, Junko Morimoto: CSF-1-dependent red pulp macrophages regulate CD4 T cell responses. J. Immunol.. 2011.02; 186 (4): 2229-2237. ( PubMed , DOI )

  11. Uchida S, Hara K, Kobayashi A, Fujimoto M, Otsuki K, Yamagata H, Hobara T, Abe N, Higuchi F, Shibata T, Hasegawa S, Kida S, Nakai A, Watanabe Y: Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 1. Proceedings of the National Academy of Sciences of the United States of America. 2011.01; 108 (4): 1681-1686. ( PubMed , DOI )

  12. Uchida S, Hara K, Kobayashi A, Otsuki K, Yamagata H, Hobara T, Suzuki T, Miyata N, Watanabe Y: Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events. Neuron. 2011.01; 69 (2): 359-372. ( PubMed , DOI )

  13. Roles of retinoic acid signaling pathway in emotional behavior 2011; 71 E270. ( DOI )

  14. Possible involvement of SIRT1, a histone deacetylase, in neural plasticity and depression-like behavior 2011; 71 E302-E303. ( DOI )

  15. Molecular mechanisms of rapid antidepressant action induced by histone deacetylase inhibitor 2011; 71 E301. ( DOI )

  16. MicroRNA-124 might be involved in the mechanism of depression-like behavior and neuronal plasticity 2011; 71 E303. ( DOI )

  17. BubR1 regulates neurite outgrowth of neuroblastoma cells 2011; 71 E334-E335. ( DOI )

  1. Yoshitake Kanazawa, Yasuyuki Saito, Yana Supriatna, Hiroyuki Tezuka, Takenori Kotani, Yoji Murata, Hideki Okazawa, Hiroshi Ohnishi, Yoshitaka Kinouchi, Yoshihisa Nojima, Toshiaki Ohteki, Tooru Shimosegawa, Takashi Matozaki: Role of SIRPα in regulation of mucosal immunity in the intestine. Genes Cells. 2010.12; 15 (12): 1189-1200. ( PubMed , DOI )

  2. Uchida S, Hara K, Kobayashi A, Funato H, Hobara T, Otsuki K, Yamagata H, McEwen BS, Watanabe Y: Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010.11; 30 (45): 15007-15018. ( PubMed , DOI )

  3. Hiroyuki Tezuka, Toshiaki Ohteki: A gas governing mucosal immunity. Vaccine. 2010.11; 28 (50): 8039-8040. ( PubMed , DOI )

  4. REST4を介した遺伝子発現調節異常はストレス脆弱性を高める(Involvement of REST4-mediated gene regulations in stress vulnerability) 2010.08; 49 (2-3): 676. ( ichushi )

  5. 気分障害患者におけるヒストン脱アセチル化酵素SIRT遺伝子群の発現変化(Altered gene expression of sirtuins in mood disorder patients) 2010.08; 49 (2-3): 677. ( ichushi )

  6. 気分障害患者におけるDNAメチル基転移酵素群遺伝子の発現解析(Altered gene expression of DNA methyltransferases in mood disorder patients) 2010.08; 49 (2-3): 677. ( ichushi )

  7. 抗うつ薬はHDAC4によるヒストン修飾を介してGDNF遺伝子の転写活性を増加させる(Antidepressants increase GDNF gene transcription through the histone modifications by HDAC4) 2010.08; 49 (2-3): 677. ( ichushi )

  8. 前脳領域レチノイン酸受容体情報伝達経路による記憶形成の制御(Regulation of memory formation by Retinoic acid receptors) 2010.08; 49 (2-3): 655. ( ichushi )

  9. ヒストン脱アセチル化酵素阻害剤による抗うつ効果の分子機構の解析(Molecular mechanisms of the antidepressant actions by histone deacetylase inhibitors) 2010.08; 49 (2-3): 676. ( ichushi )

  10. Yong-Mei Guo, Keiko Ishii, Makoto Hirokawa, Hiroyuki Tagawa, Hideaki Ohyagi, Yoshihiro Michishita, Kumi Ubukawa, Junsuke Yamashita, Toshiaki Ohteki, Nobuyuki Onai, Kazuyoshi Kawakami, Weiguo Xiao, Kenichi Sawada: CpG-ODN 2006 and human parvovirus B19 genome consensus sequences selectively inhibit growth and development of erythroid progenitor cells. Blood. 2010.06; 115 (22): 4569-4579. ( PubMed , DOI )

  11. Hobara T, Uchida S, Otsuki K, Matsubara T, Funato H, Matsuo K, Suetsugi M, Watanabe Y: Altered gene expression of histone deacetylases in mood disorder patients. Journal of psychiatric research. 2010.04; 44 (5): 263-270. ( PubMed , DOI )

  12. Otsuki K, Uchida S, Wakabayashi Y, Matsubara T, Hobara T, Funato H, Watanabe Y: Aberrant REST-mediated transcriptional regulation in major depressive disorder. Journal of psychiatric research. 2010.04; 44 (6): 378-384. ( PubMed , DOI )

  13. Hiroyuki Tezuka, Toshiaki Ohteki: Regulation of intestinal homeostasis by dendritic cells. Immunol Rev. 2010.03; 234 (1): 247-258. ( PubMed , DOI )

  14. Uchida S, Hara K, Kobayashi A, Otsuki K, Hobara T, Yamagata H, Watanabe Y: Maternal and genetic factors in stress-resilient and -vulnerable rats: a cross-fostering study. Brain research. 2010.02; 1316 43-50. ( PubMed , DOI )

  15. Jumpei Asano, Hiroyuki Tada, Nobuyuki Onai, Taku Sato, Yasuo Horie, Yukari Fujimoto, Koichi Fukase, Akira Suzuki, Tak W Mak, Toshiaki Ohteki: Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo. J Immunol. 2010.01; 184 (2): 736-745. ( PubMed , DOI )

  16. Hobara, T; Uchida, S; Otsuki, K; Yamagata, H; Watanabe, Y: Molecular mechanisms of the antidepressant actions by histone deacetylase inhibitors NEUROSCIENCE RESEARCH. 2010; 68 E316. ( DOI )

  17. Uchida, S; Hara, K; Kobayashi, A; Watanabe, Y: Involvement of REST4-mediated gene regulations in stress vulnerability NEUROSCIENCE RESEARCH. 2010; 68 E316. ( DOI )

  18. Otsuki, K; Uchida, S; Yamagata, H; Watanabe, Y: Antidepressants increase GDNF gene transcription through the histone modifications by HDAC4 NEUROSCIENCE RESEARCH. 2010; 68 E317. ( DOI )

  19. Abe, N; Uchida, S; Otsuki, K; Hobara, T; Higuchi, F; Watanabe, Y: Altered gene expression of sirtuins in mood disorder patients NEUROSCIENCE RESEARCH. 2010; 68 E318. ( DOI )

  20. Higuchi, F; Uchida, S; Otsuki, K; Teruyuki, H; Abe, N; Watanabe, Y: Altered gene expression of DNA methyltransferases in mood disorder patients NEUROSCIENCE RESEARCH. 2010; 68 E318. ( DOI )

  1. Takayuki Tomita, Takanori Kanai, Teruji Totsuka, Yasuhiro Nemoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Naoya Sakamoto, Toshiaki Ohteki, Toshifumi Hibi, Mamoru Watanabe: IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis. Eur J Immunol. 2009.10; 39 (10): 2737-2747. ( PubMed , DOI )

  2. Masashi Kanayama, Daisuke Kurotaki, Junko Morimoto, Tsuyoshi Asano, Yutaka Matsui, Yosuke Nakayama, Yoshinari Saito, Koyu Ito, Chiemi Kimura, Norimasa Iwasaki, Koji Suzuki, Tanenobu Harada, Hong Mei Li, Jun Uehara, Tadaaki Miyazaki, Akio Minami, Shigeyuki Kon, Toshimitsu Uede: Alpha9 integrin and its ligands constitute critical joint microenvironments for development of autoimmune arthritis. J. Immunol.. 2009.06; 182 (12): 8015-8025. ( PubMed , DOI )

  3. Taku Sato, Nobuyuki Onai, Hiroki Yoshihara, Fumio Arai, Toshio Suda, Toshiaki Ohteki: Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. Nat Med. 2009.06; 15 (6): 696-700. ( PubMed , DOI )

  4. Jun Yamada, Junji Hamuro, Atsuki Fukushima, Toshiaki Ohteki, Kazuto Terai, Yoichiro Iwakura, Hideo Yagita, Shigeru Kinoshita: MHC-matched corneal allograft rejection in an IFN-gamma/IL-17-independent manner in C57BL/6 mice. Invest Ophthalmol Vis Sci. 2009.05; 50 (5): 2139-2146. ( PubMed , DOI )

  5. Koyu Ito, Shigeyuki Kon, Yosuke Nakayama, Daisuke Kurotaki, Yoshinari Saito, Masashi Kanayama, Chiemi Kimura, Hongyan Diao, Junko Morimoto, Yutaka Matsui, Toshimitsu Uede: The differential amino acid requirement within osteopontin in alpha4 and alpha9 integrin-mediated cell binding and migration. Matrix Biol.. 2009.01; 28 (1): 11-19. ( PubMed , DOI )

  6. Positive and negative regulation of memory formation by Retinoic acid receptors 2009; 65 S234. ( DOI )

  7. Uchida, S; Otsuki, K; Hara, K; Kobayashi, A; Hobara, T; Watanabe, Y: HDAC2-mediated epigenetic repression of the GDNF gene in the striatum modulates behavioral vulnerability to stress NEUROSCIENCE RESEARCH. 2009; 65 S184. ( DOI )

  8. Hobara, T; Uchida, S; Otsuki, K; Matsubara, T; Funato, H; Matsuo, K; Suetsugi, M; Watanabe, Y: Altered gene expression of histone deacetylases in mood disorder patients NEUROSCIENCE RESEARCH. 2009; 65 S90. ( DOI )

  9. Otsuki, K; Uchida, S; Watanabe, Y: Antidepressant drugs upregurate glial astrocyte GDNF gene transcription throgh the histone modifications NEUROSCIENCE RESEARCH. 2009; 65 S254. ( DOI )

  1. Otsuki, K; Uchida, S; Watanuki, T; Wakabayashi, Y; Fujimoto, M; Matsubara, T; Funato, H; Watanabe, Y: Altered expression of neurotrophic factors in patients with major depression JOURNAL OF PSYCHIATRIC RESEARCH. 2008.10; 42 (14): 1145-1153. ( PubMed , DOI )

  2. Watanuki, T; Funato, H; Uchida, S; Matsubara, T; Kobayashi, A; Wakabayashi, Y; Otsuki, K; Nishida, A; Watanabe, Y: Increased expression of splicing factor SRp20 mRNA in bipolar disorder patients JOURNAL OF AFFECTIVE DISORDERS. 2008.09; 110 (1-2): 62-69. ( PubMed , DOI )

  3. 発達期うつ様行動のリスク下における転写抑制因子REST/NRSFを介した遺伝子発現調節の役割(Role of REST/NRSF repressor-mediated gene regulations in the risk of developing depression-like behavior) 2008.08; 47 (2-3): 249. ( ichushi )

  4. Wakabayashi, Y; Uchida, S; Funato, H; Matsubara, T; Watanuki, T; Otsuki, K; Fujimoto, M; Nishida, A; Watanabe, Y: State-dependent changes in the expression levels of NCAM-140 and L1 in the peripheral blood cells of bipolar disorders, but not in the major depressive disorders PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2008.07; 32 (5): 1199-1205. ( PubMed , DOI )

  5. Fumi Miyagawa, Yutaka Tagaya, Brian S Kim, Hiral J Patel, Kazuto Ishida, Toshiaki Ohteki, Thomas A Waldmann, Stephen I Katz: IL-15 serves as a costimulator in determining the activity of autoreactive CD8 T cells in an experimental mouse model of graft-versus-host-like disease. J Immunol. 2008.07; 181 (2): 1109-1119. ( PubMed )

  6. Fujimoto, M; Uchida, S; Watanuki, T; Wakabayashi, Y; Otsuki, K; Matsubara, T; Suetsugi, M; Funato, H; Watanabe, Y: Reduced expression of glyoxalase-1 mRNA in mood disorder patients NEUROSCIENCE LETTERS. 2008.06; 438 (2): 196-199. ( PubMed , DOI )

  7. Fujimoto, J; Bando, T; Minoshima, M; Uchida, S; Iwasaki, M; Shinohara, K; Sugiyama, H: Detection of triplet repeat sequences in the double-stranded DNA using pyrene-functionalized pyrrole-imidazole polyamides with rigid linkers BIOORGANIC & MEDICINAL CHEMISTRY. 2008.06; 16 (11): 5899-5907. ( PubMed , DOI )

  8. Uchida, S; Nishida, A; Hara, K; Kamemoto, T; Suetsugi, M; Fujimoto, M; Watanuki, T; Wakabayashi, Y; Otsuki, K; McEwen, BS; Watanabe, Y: Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor EUROPEAN JOURNAL OF NEUROSCIENCE. 2008.05; 27 (9): 2250-2261. ( PubMed , DOI )

  9. Shoko Kuroda, Miki Nishio, Takehiko Sasaki, Yasuo Horie, Koichi Kawahara, Masato Sasaki, Miyuki Natsui, Takashi Matozaki, Hiroyuki Tezuka, Toshiaki Ohteki, Irmgard Förster, Tak W Mak, Toru Nakano, Akira Suzuki: Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages. Eur J Immunol. 2008.05; 38 (5): 1331-1340. ( PubMed , DOI )

  10. Magali Terme, Nathalie Chaput, Behazine Combadiere, Averil Ma, Toshiaki Ohteki, Laurence Zitvogel: Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells. J Immunol. 2008.04; 180 (7): 4679-4686. ( PubMed )

  11. Fujimoto, M; Uchida, S; Hara, K; Watanabe, Y: Morphological alterations of hippocampal pyramidal neurons induced by chronic stress in F344 rats PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2008.02; 62 (1): S8.

  12. Morphological alterations of hippocampal pyramidal neurons induced by chronic stress in F344 rats 2008.02; 62 (1): S8.

  13. Otsuki, K; Uchida, S; Watanuki, T; Wakabayashi, Y; Matsubara, T; Watanabe, Y: Expression analysis of neurotrophic factors in patients with mood disorders PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2008.02; 62 (1): S14.

  14. Kentaro Matsuzaki, Kenichi Miyazaki, Seiichiro Sakai, Hiromu Yawo, Norihito Nakata, Shigeki Moriguchi, Kohji Fukunaga, Akihito Yokosuka, Yutaka Sashida, Yoshihiro Mimaki, Tohru Yamakuni, Yasushi Ohizumi: Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus. Eur J Pharmacol. 2008.01; 578 (2-3): 194-200. ( PubMed , DOI )

  15. Retinoic acid receptors function as positive regulators for memory formation 2008; 61 S193.

  16. Involvement of REST/NRSF repressor-mediated gene regulations in the risk of developing depression-like behavior in the maternally separated rats 2008; 61 S207.

  17. Otsuki, K; Uchida, S; Hara, K; Kobayashi, A; Watanabe, Y: Involvement of glucocorticoids-mediated downregulation of GDNF expression in the susceptibility to chronic ultra mild stress NEUROSCIENCE RESEARCH. 2008; 61 S206.

  18. Involvement of glucocorticoids-mediated downregulation of GDNF expression in the susceptibility to chronic ultra mild stress 2008; 61 S206.

  1. Yoshinari Saito, Shigeyuki Kon, Yukio Fujiwara, Yosuke Nakayama, Daisuke Kurotaki, Naoki Fukuda, Chiemi Kimura, Masashi Kanayama, Koyu Ito, Hongyan Diao, Yutaka Matsui, Yasuo Komatsu, Eiko Ohtsuka, Toshimitsu Uede: Osteopontin small interfering RNA protects mice from fulminant hepatitis. Hum. Gene Ther.. 2007.12; 18 (12): 1205-1214. ( PubMed , DOI )

  2. Nobuyuki Onai, Aya Obata-Onai, Michael A Schmid, Toshiaki Ohteki, David Jarrossay, Markus G Manz: Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol. 2007.11; 8 (11): 1207-1216. ( PubMed , DOI )

  3. Toshiaki Ohteki: The dynamics of dendritic cell: mediated innate immune regulation. Allergol Int. 2007.09; 56 (3): 209-214. ( PubMed , DOI )

  4. Hiroyuki Tezuka, Yukiko Abe, Makoto Iwata, Hajime Takeuchi, Hiromichi Ishikawa, Masayuki Matsushita, Tetsuo Shiohara, Shizuo Akira, Toshiaki Ohteki: Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells. Nature. 2007.08; 448 (7156): 929-933. ( PubMed , DOI )

  5. Suetsugi, M; Mizuki, Y; Yamamoto, K; Uchida, S; Watanabe, Y: The effect of placebo administration on the first-night effect in healthy young volunteers PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2007.05; 31 (4): 839-847. ( PubMed , DOI )

  6. Chronic reduction in dietary tryptophan leads to a selective impairment of contextual fear memory in mice 2007.05; 1149 149-156. ( PubMed , DOI )

  7. Wakabayashi, Y; Uchida, S; Matsubara, T; Funato, H; Kobayashi, A; Nishida, A; Watanabe, Y: Expression analysis of cell adhesion molecules in mood disorders PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2007.04; 61 (2): S6.

  8. Expression analysis of cell adhesion molecules in mood disorders 2007.04; 61 (2): S6.

  9. Hiroyuki Kishimoto, Toshiaki Ohteki, Nobuyuki Yajima, Koichi Kawahara, Miyuki Natsui, Satoru Kawarasaki, Koichi Hamada, Yasuo Horie, Yoshiaki Kubo, Seiji Arase, Masaru Taniguchi, Bart Vanhaesebroeck, Tak Wah Mak, Toru Nakano, Shigeo Koyasu, Takehiko Sasaki, Akira Suzuki: The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells. Blood. 2007.04; 109 (8): 3316-3324. ( PubMed , DOI )

  10. Expression analysis of adhesion molecule CD44 isoform mRNA in the patients with mood disorders 2007; 58 S124.

  11. Otsuki, K; Uchida, S; Matsubara, T; Watanuki, T; Wakabayashi, Y; Watanabe, Y: Expression analysis of neurotrophic factors in patients with mood disorders NEUROSCIENCE RESEARCH. 2007; 58 S123. ( DOI )

  12. Watanuki, T; Uchida, S; Funato, H; Otsuki, K; Wakabayashi, Y; Watanabe, Y: Expression analysis of adhesion molecule CD44 isoform mRNA in the patients with mood disorders NEUROSCIENCE RESEARCH. 2007; 58 S124. ( DOI )

  13. Roles of retinoic acid receptors in learning and memory 2007; 58 S111.

  14. Uchida, S; Nishida, A; Hara, K; Suetsugi, M; Fujimoto, M; Watanabe, Y: Involvement of microRNA-mediated downregulation of glucocorticoid receptor in vulnerability to stress NEUROSCIENCE RESEARCH. 2007; 58 S166. ( DOI )

  15. Involvement of microRNA-mediated downregulation of glucocorticoid receptor in vulnerability to stress 2007; 58 S166.

  16. Expression analysis of neurotrophic factors in patients with mood disorders 2007; 58 S123.

  1. Toshiaki Ohteki, Hiroyuki Tada, Kazuto Ishida, Taku Sato, Chikako Maki, Taketo Yamada, Junji Hamuro, Shigeo Koyasu: Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo. J Exp Med. 2006.10; 203 (10): 2329-2338. ( PubMed , DOI )

  2. Seiichi Kuwajima, Taku Sato, Kazuto Ishida, Hiroyuki Tada, Hiroyuki Tezuka, Toshiaki Ohteki: Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation. Nat Immunol. 2006.07; 7 (7): 740-746. ( PubMed , DOI )

  3. Noriko Kitanaka, Yuji Owada, Ryuhei Okuyama, Hiroyuki Sakagami, Mohammad Reza Nourani, Setsuya Aiba, Hiroshi Furukawa, Makoto Watanabe, Masao Ono, Toshiaki Ohteki, Hisatake Kondo: Epidermal-type fatty acid binding protein as a negative regulator of IL-12 production in dendritic cells. Biochem Biophys Res Commun. 2006.06; 345 (1): 459-466. ( PubMed , DOI )

  4. Tight regulation of transgene expression by tetracycline-dependent activator and repressor in brain 2006.02; 5 (1): 96-106. ( PubMed , DOI )

  5. Expression analysis of alternative splicing-related SR protein family in patients with mood disorders 2006; 55 S233.

  6. Watanuki, T; Funato, H; Matsubara, T; Uchida, S; Watanabe, Y: Expression analysis of alternative splicing-related SR protein family in patients with mood disorders NEUROSCIENCE RESEARCH. 2006; 55 S233.

  1. Hiroyuki Tada, Setsuya Aiba, Ken-Ichiro Shibata, Toshiaki Ohteki, Haruhiko Takada: Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells. Infect Immun. 2005.12; 73 (12): 7967-7976. ( PubMed , DOI )

  2. Chronic reduction in dietary tryptophan leads to changes in the emotional response to stress in mice 2005.06; 51 (3): 175-181. ( PubMed , DOI )

  3. Uchida Shusaku, Kitamoto Aya, Umeeda Hisahiro, Nakagawa Nobutoshi, Masushige Shoichi, Kida Satoshi: マウスにおいて食餌中慢性的トリプトファン減少はストレスに対する情動反応に変化を来たす(Chronic Reduction in Dietary Tryptophan Leads to Changes in the Emotional Response to Stress in Mice) Journal of Nutritional Science and Vitaminology. 2005.06; 51 (3): 175-181. ( ichushi )

  1. Kenya Honda, Shinya Sakaguchi, Chigusa Nakajima, Ai Watanabe, Hideyuki Yanai, Misako Matsumoto, Toshiaki Ohteki, Tsuneyasu Kaisho, Akinori Takaoka, Shizuo Akira, Tsukasa Seya, Tadatsugu Taniguchi: Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc Natl Acad Sci USA. 2003.09; 100 (19): 10872-10877. ( PubMed , DOI )

  2. Kaisa Holmberg, Sanjeev Mariathasan, Toshiaki Ohteki, Pamela S Ohashi, Nicholas R J Gascoigne: TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCR. J Immunol. 2003.09; 171 (5): 2427-2434. ( PubMed )

  3. Toshimasa Yamauchi, Junji Kamon, Yusuke Ito, Atsushi Tsuchida, Takehiko Yokomizo, Shunbun Kita, Takuya Sugiyama, Makoto Miyagishi, Kazuo Hara, Masaki Tsunoda, Koji Murakami, Toshiaki Ohteki, Shoko Uchida, Sato Takekawa, Hironori Waki, Nelson H Tsuno, Yoichi Shibata, Yasuo Terauchi, Philippe Froguel, Kazuyuki Tobe, Shigeo Koyasu, Kazunari Taira, Toshio Kitamura, Takao Shimizu, Ryozo Nagai, Takashi Kadowaki: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003.06; 423 (6941): 762-769. ( PubMed , DOI )

  4. Harumi Suzuki, Satoshi Matsuda, Yasuo Terauchi, Mari Fujiwara, Toshiaki Ohteki, Tomoichiro Asano, Timothy W Behrens, Taku Kouro, Kiyoshi Takatsu, Takashi Kadowaki, Shigeo Koyasu: PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction. Nat Immunol. 2003.03; 4 (3): 280-286. ( PubMed , DOI )

  5. Samuel D Saibil, Toshiaki Ohteki, Forest M White, Mark Luscher, Arsen Zakarian, Alisha Elford, Jeffery Shabanowitz, Hiroshi Nishina, Patrice Hugo, Josef Penninger, Brian Barber, Donald F Hunt, Pamela S Ohashi: Weak agonist self-peptides promote selection and tuning of virus-specific T cells. Eur J Immunol. 2003.03; 33 (3): 685-696. ( PubMed , DOI )

  1. Yukie Murata, Toshiaki Ohteki, Shigeo Koyasu, Junji Hamuro: IFN-gamma and pro-inflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension. Eur J Immunol. 2002.10; 32 (10): 2866-2873. ( PubMed , DOI )

  2. Toshiaki Ohteki: Critical role for IL-15 in innate immunity. Curr Mol Med. 2002.06; 2 (4): 371-380. ( PubMed )

  3. Kristine M Garza, Kim J McKall-Faienza, Toshiaki Otheki, Arsen Zakarian, Bernhard Odermatt, Pamela S Ohashi: Enhanced T cell responses contribute to the genetic predisposition of CD8-mediated spontaneous autoimmunity. Eur J Immunol. 2002.03; 32 (3): 885-894. ( PubMed , DOI )

  1. T Ohteki, K Suzue, C Maki, T Ota, S Koyasu: Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response. Nat Immunol. 2001.12; 2 (12): 1138-1143. ( PubMed , DOI )

  2. T Ohteki, C Maki, S Koyasu: Overexpression of Bcl-2 differentially restores development of thymus-derived CD4-8+ T cells and intestinal intraepithelial T cells in IFN-regulatory factor-1-deficient mice. J Immunol. 2001.06; 166 (11): 6509-6513. ( PubMed )

  3. A Suzuki, M T Yamaguchi, T Ohteki, T Sasaki, T Kaisho, Y Kimura, R Yoshida, A Wakeham, T Higuchi, M Fukumoto, T Tsubata, P S Ohashi, S Koyasu, J M Penninger, T Nakano, T W Mak: T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity. 2001.05; 14 (5): 523-534. ( PubMed )

  4. T Ohteki, S Koyasu: Role of antigen-presenting cells in innate immune system. Arch Immunol Ther Exp (Warsz.). 2001.01; 49 Suppl 1 S47-S52. ( PubMed )

  1. T Ohteki, M Parsons, A Zakarian, R G Jones, L T Nguyen, J R Woodgett, P S Ohashi: Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3. J Exp Med. 2000.07; 192 (1): 99-104. ( PubMed )

  1. T Ohteki, A Hessel, M F Bachmann, A Zakarian, E Sebzda, M S Tsao, K McKall-Faienza, B Odermatt, P S Ohashi: Identification of a cross-reactive self ligand in virus-mediated autoimmunity. Eur J Immunol. 1999.09; 29 (9): 2886-2896. ( PubMed , DOI )

  2. T Ohteki, T Fukao, K Suzue, C Maki, M Ito, M Nakamura, S Koyasu: Interleukin 12-dependent interferon gamma production by CD8alpha+ lymphoid dendritic cells. J Exp Med. 1999.06; 189 (12): 1981-1986. ( PubMed )

  3. T Ohteki, C Maki, S Koyasu, T W Mak, P S Ohashi: Cutting edge: LFA-1 is required for liver NK1.1+TCR alpha beta+ cell development: evidence that liver NK1.1+TCR alpha beta+ cells originate from multiple pathways. J Immunol. 1999.04; 162 (7): 3753-3756. ( PubMed )

  4. E Sebzda, S Mariathasan, T Ohteki, R Jones, M F Bachmann, P S Ohashi: Selection of the T cell repertoire. Annu Rev Immunol. 1999.01; 17 829-874. ( PubMed , DOI )

  1. S Mariathasan, M F Bachmann, D Bouchard, T Ohteki, P S Ohashi: Degree of TCR internalization and Ca2+ flux correlates with thymocyte selection. J Immunol. 1998.12; 161 (11): 6030-6037. ( PubMed )

  2. T Ohteki, H Yoshida, T Matsuyama, G S Duncan, T W Mak, P S Ohashi: The transcription factor interferon regulatory factor 1 (IRF-1) is important during the maturation of natural killer 1.1+ T cell receptor-alpha/beta+ (NK1+ T) cells, natural killer cells, and intestinal intraepithelial T cells. J Exp Med. 1998.03; 187 (6): 967-972. ( PubMed )

  3. H Yoshida, H Nishina, H Takimoto, L E Marengère, A C Wakeham, D Bouchard, Y Y Kong, T Ohteki, A Shahinian, M Bachmann, P S Ohashi, J M Penninger, G R Crabtree, T W Mak: The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity. 1998.01; 8 (1): 115-124. ( PubMed )

  1. T Ohteki, S Ho, H Suzuki, T W Mak, P S Ohashi: Role for IL-15/IL-15 receptor beta-chain in natural killer 1.1+ T cell receptor-alpha beta+ cell development. J Immunol. 1997.12; 159 (12): 5931-5935. ( PubMed )

  2. M F Bachmann, T Ohteki, K M Faienza, A Zakarian, D Kägi, D E Speiser, P S Ohashi: Altered peptide ligands trigger perforin- rather than Fas-dependent cell lysis. J Immunol. 1997.11; 159 (9): 4165-4170. ( PubMed )

  3. M Shimamura, T Ohteki, U Beutner, H R MacDonald: Lack of directed V alpha 14-J alpha 281 rearrangements in NK1+ T cells. Eur J Immunol. 1997.06; 27 (6): 1576-1579. ( PubMed , DOI )

  4. M Shimamura, T Ohteki, P Launois, A M Garcia, H R MacDonald: Thymus-independent generation of NK1+ T cells in vitro from fetal liver precursors. J Immunol. 1997.04; 158 (8): 3682-3689. ( PubMed )

  5. U Beutner, P Launois, T Ohteki, J A Louis, H R MacDonald: Natural killer-like T cells develop in SJL mice despite genetically distinct defects in NK1.1 expression and in inducible interleukin-4 production. Eur J Immunol. 1997.04; 27 (4): 928-934. ( PubMed , DOI )

  1. DE Speiser, E Sebzda, T Ohteki, M F Bachmann, K Pfeffer, TW Mak, PS Ohashi: Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo. Eur. J. Immunol.. 1996.12; 26 (12): 3055-3060. ( PubMed , DOI )

  2. T Ohteki, H R MacDonald: Stringent V beta requirement for the development of NK1.1+ T cell receptor-alpha/beta+ cells in mouse liver. J. Exp. Med.. 1996.03; 183 (3): 1277-1282. ( PubMed )

  3. T Ohteki, A Wilson, S Verbeek, H R MacDonald, H Clevers: Selectively impaired development of intestinal T cell receptor gamma delta+ cells and liver CD4+ NK1+ T cell receptor alpha beta+ cells in T cell factor-1-deficient mice. Eur. J. Immunol.. 1996.02; 26 (2): 351-355. ( PubMed , DOI )

  1. P Launois, T Ohteki, K Swihart, H R MacDonald, J A Louis: In susceptible mice, Leishmania major induce very rapid interleukin-4 production by CD4+ T cells which are NK1.1-. Eur. J. Immunol.. 1995.12; 25 (12): 3298-3307. ( PubMed , DOI )

  2. P R Walker, T Ohteki, J A Lopez, H R MacDonald, J L Maryanski: Distinct phenotypes of antigen-selected CD8 T cells emerge at different stages of an in vivo immune response. J. Immunol.. 1995.10; 155 (7): 3443-3452. ( PubMed )

  3. T Ohteki, M Iwamoto, S Izui, H R MacDonald: Reduced development of CD4-8-B220+ T cells but normal autoantibody production in lpr/lpr mice lacking major histocompatibility complex class I molecules. Eur. J. Immunol.. 1995.01; 25 (1): 37-41. ( PubMed , DOI )

  1. T Ohteki, H R MacDonald: Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice. J. Exp. Med.. 1994.08; 180 (2): 699-704. ( PubMed )

  2. J P Rosat, M Schreyer, T Ohteki, G A Waanders, H R MacDonald, J A Louis: Selective expansion of activated V delta 4+ cells during experimental infection of mice with Leishmania major. Eur. J. Immunol.. 1994.02; 24 (2): 496-499. ( PubMed , DOI )

  1. T Ohteki, H R MacDonald: Expression of the CD28 costimulatory molecule on subsets of murine intestinal intraepithelial lymphocytes correlates with lineage and responsiveness. Eur. J. Immunol.. 1993.06; 23 (6): 1251-1255. ( PubMed , DOI )

  2. N Koyamada, T Ohteki, T Abo, T Fukumori, N Ohkouchi, S Satomi, Y Taguchi, A Kusumi, S Mori, K Kumagai: Induction of specific tolerance by hepatic double-negative CD4-8- alpha beta T cells of mice immunized with allogeneic cells via the portal vein in vivo [corrected]. Cell. Immunol.. 1993.06; 149 (1): 107-116. ( PubMed )

  3. T Ohteki, S Okamoto, M Nakamura, E Nemoto, K Kumagai: Elevated production of interleukin 6 by hepatic MNC correlates with ICAM-1 expression on the hepatic sinusoidal endothelial cells in autoimmune MRL/lpr mice. Immunol. Lett.. 1993.05; 36 (2): 145-152. ( PubMed )

  4. T Ohteki, T Abo, A Kusumi, T Sasaki, S Shibata, S Seki, K Kumagai: Age-associated increase of CD5+ B cells in the liver of autoimmune (NZB x NZW) F1 mice. Microbiol. Immunol.. 1993.01; 37 (3): 221-228. ( PubMed )

  1. T Iiai, H Watanabe, S Seki, K Sugiura, K Hirokawa, M Utsuyama, H Takahashi-Iwanaga, T Iwanaga, T Ohteki, T Abo: Ontogeny and development of extrathymic T cells in mouse liver. Immunology. 1992.12; 77 (4): 556-563. ( PubMed )

  2. A Kusumi, T Abo, T Masuda, K Sugiura, S Seki, T Ohteki, R Okuyama, K Kumagai: Lymphotoxin activates hepatic T cells and simultaneously induces profound thymic atrophy. Immunology. 1992.10; 77 (2): 177-184. ( PubMed )

  3. T Ohteki, R Okuyama, S Seki, T Abo, K Sugiura, A Kusumi, T Ohmori, H Watanabe, K Kumagai: Age-dependent increase of extrathymic T cells in the liver and their appearance in the periphery of older mice. J. Immunol.. 1992.09; 149 (5): 1562-1570. ( PubMed )

  4. T Abo, A Kusumi, S Seki, T Ohteki, K Sugiura, T Masuda, H Rikiishi, T Iiai, K Kumagai: Activation of extrathymic T cells in the liver and reciprocal inactivation of intrathymic T cells by bacterial stimulation. Cell. Immunol.. 1992.06; 142 (1): 125-136. ( PubMed )

  5. R Okuyama, T Abo, S Seki, T Ohteki, K Sugiura, A Kusumi, K Kumagai: Estrogen administration activates extrathymic T cell differentiation in the liver. J. Exp. Med.. 1992.03; 175 (3): 661-669. ( PubMed )

  6. H Watanabe, K Ohtsuka, M Kimura, Y Ikarashi, K Ohmori, A Kusumi, T Ohteki, S Seki, T Abo: Details of an isolation method for hepatic lymphocytes in mice. J. Immunol. Methods. 1992.02; 146 (2): 145-154. ( PubMed )

  1. T Masuda, T Ohteki, T Abo, S Seki, S Nose, H Nagura, K Kumagai: Expansion of the population of double negative CD4-8- T alpha beta-cells in the liver is a common feature of autoimmune mice. J. Immunol.. 1991.11; 147 (9): 2907-2912. ( PubMed )

  2. S Seki, T Abo, K Sugiura, T Ohteki, T Kobata, H Yagita, K Okumura, H Rikiishi, T Masuda, K Kumagai: Reciprocal T cell responses in the liver and thymus of mice injected with syngeneic tumor cells. Cell. Immunol.. 1991.10; 137 (1): 46-60. ( PubMed )

  3. T Abo, T Ohteki, S Seki, N Koyamada, Y Yoshikai, T Masuda, H Rikiishi, K Kumagai: The appearance of T cells bearing self-reactive T cell receptor in the livers of mice injected with bacteria. J. Exp. Med.. 1991.08; 174 (2): 417-424. ( PubMed )

  4. S Seki, T Abo, T Ohteki, K Sugiura, K Kumagai: Unusual alpha beta-T cells expanded in autoimmune lpr mice are probably a counterpart of normal T cells in the liver. J. Immunol.. 1991.08; 147 (4): 1214-1221. ( PubMed )

  5. T Ohteki, T Abo, S Seki, T Kobata, H Yagita, K Okumura, K Kumagai: Predominant appearance of gamma/delta T lymphocytes in the liver of mice after birth. Eur. J. Immunol.. 1991.07; 21 (7): 1733-1740. ( PubMed , DOI )

  1. J Satoh, H Seino, S Shintani, S Tanaka, T Ohteki, T Masuda, T Nobunaga, T Toyota: Inhibition of type 1 diabetes in BB rats with recombinant human tumor necrosis factor-alpha. J. Immunol.. 1990.09; 145 (5): 1395-1399. ( PubMed )

  2. S Seki, T Abo, T Masuda, T Ohteki, A Kanno, K Takeda, H Rikiishi, H Nagura, K Kumagai: Identification of activated T cell receptor gamma delta lymphocytes in the liver of tumor-bearing hosts. J. Clin. Invest.. 1990.08; 86 (2): 409-415. ( PubMed , DOI )

  3. T Ohteki, S Seki, T Abo, K Kumagai: Liver is a possible site for the proliferation of abnormal CD3+4-8- double-negative lymphocytes in autoimmune MRL-lpr/lpr mice. J. Exp. Med.. 1990.07; 172 (1): 7-12. ( PubMed )

  4. Toshiaki Ohteki: Analysis of lymphoproliferative disorders in autoimmune model mouse (MRL-lpr/lpr) accompanying Sjögren’s syndrome. Tohoku Univ Dent J. 1990.01; 9 73-82.

  1. J Satoh, H Seino, T Abo, S Tanaka, S Shintani, S Ohta, K Tamura, T Sawai, T Nobunaga, T Oteki: Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice. J. Clin. Invest.. 1989.10; 84 (4): 1345-1348. ( PubMed , DOI )

  1. Noriyuki Matsuda: Current methods and problems to monitor mitophagy correctly - considered from Parkin study. Experimental Medicine. 2023.03; 41 (5): 682-687. ( ichushi )

  1. 津山 淳, 七田 崇: 【脳の半分を占めるグリア細胞 脳と心と体をつなぐ"膠"】(第2章)グリア細胞と神経免疫・臓器連関 脳虚血後の炎症と修復における自然免疫の役割 実験医学. 2019.11; 37 (17): 2861-2866. ( ichushi )

  1. Masashi Kanayama, Mari L. Shinohara: Balancing population sizes of myeloid and lymphoid cells by osteopontin isoforms 2018.03; 63 (3): 219-224.

  2. Toshiaki Ohteki: Identification of a human progenitor strictly committed to monocytic differentiation: a counterpart of mouse cMoPs. Rinsho Ketsueki. 2018; 59 (6): 812-818. ( PubMed , DOI )

  1. 佐藤 裕介, 尾勝 圭, 佐伯 泰, 山野 晃史, 松田 憲之, 海保 愛, 山形 敦史, 伊藤 桜子, 石川 稔, 橋本 祐一, 田中 啓二, 深井 周也: ユビキチン・コード:細胞内の最も難解な暗号を読む USP30によるLys6結合型ユビキチン鎖特異的切断機構の構造的基盤 生命科学系学会合同年次大会. 2017.12; 2017年度 [4AW13-6]. ( ichushi )

  2. 平石 萌, 小谷野 史香, 久永 眞市, 中田 和人, 田中 啓二, 松田 憲之: Parkin機能喪失に由来するパーキンソン病モデルマウスの作製と解析 生命科学系学会合同年次大会. 2017.12; 2017年度 [2P-1068]. ( ichushi )

  3. 小島 和華, 山野 晃史, 木村 まゆみ, Bruno Queliconi, 田中 啓二, 松田 憲之: DJ-1の局在解析から見出す非典型的ミトコンドリア局在化シグナル 生命科学系学会合同年次大会. 2017.12; 2017年度 [1P-0324]. ( ichushi )

  4. 津山 淳, 吉村 昭彦, 七田 崇: マクロファージによる脳虚血後炎症の制御 炎症と免疫. 2017.10; 25 (6): 547-552. ( ichushi )

  5. Regulation of cancer cell immunogenicity by the Hippo intracellular pathway 2017.10; 68 (4): 438-444.

  6. 内田周作, 樋口尚子, 山形弘隆, 渡辺義文: うつ病・不安障害におけるサーチュインの役割と創薬への可能性 日本神経精神薬理学会プログラム・抄録集. 2017.09; 39回・47回 111. ( ichushi )

  7. 山形弘隆, 内田周作, 松尾幸治, 原田健一郎, 宮田茂雄, 福田正人, 三國雅彦, 三國雅彦, 三國雅彦, 渡邉義文: うつ病患者白血球とうつ病モデルマウス血液に共通した遺伝子発現変化 日本神経精神薬理学会プログラム・抄録集. 2017.09; 39回・47回 168. ( ichushi )

  8. 津山淳: 幹細胞から見た脳の発生進化 日本進化学会大会プログラム・講演要旨集(Web). 2017.08; 19th 63 (WEB ONLY).

  9. 津山淳: エピゲノム情報から神経幹細胞のゲノム進化領域を探る 日本遺伝学会大会プログラム・予稿集. 2017.08; 89th 92.

  10. PINK1-PhosphoUbiquitin-Parkin axis for degradation of damaged mitochondria 2017.08; 262 (6): 603-608.

  11. 吉田雪子, 安田さや香, 藤田敏治, 濱崎万穂, 村上有沙, 川脇純子, 岩井一宏, 佐伯泰, 吉森保, 松田憲之, 田中啓二: SCFFBXO27による損傷リソソームから細胞質へ露出した糖蛋白質のユビキチン化はリソファジーの引き金となる 日本生化学会大会(Web). 2017; 90th ROMBUNNO.4LT01‐08(3P‐0149) (WEB ONLY)-0149)]. ( ichushi )

  1. 山形弘隆, 内田周作, 樋口文宏, 芳原輝之, 渡邉義文, 渡邉義文: BubR1を介した神経突起伸展の制御 日本生物学的精神医学会(Web). 2016; 38th 120 (WEB ONLY).

  2. 内田周作, 山形弘隆, 芳原輝之, 樋口文宏, 樋口尚子, 渡辺義文: ストレス適応破綻からみたうつ病態における神経可塑性異常とその分子基盤 日本生物学的精神医学会(Web). 2016; 38th 2 (WEB ONLY).

  3. 山形弘隆, 内田周作, 樋口文宏, 渡邉義文: うつ病と神経細胞死 日本生物学的精神医学会(Web). 2016; 38th 19 (WEB ONLY).

  4. 渡辺義文, 内田周作, 山形弘隆, 樋口文宏: うつ病の発病脆弱性の分子機構を考える 日本生物学的精神医学会(Web). 2016; 38th 17 (WEB ONLY).

  1. 松田憲之, 小谷野史香: Phos-Tag PAGE: uncovering the role of phosphorylation resisting Parkinson's disease 電気泳動(Web). 2015.10; 59 (2):

  2. 内田周作, 内田周作, 芳原輝之, 樋口文宏, 樋口尚子, 山形弘隆, 渡邉義文: エピジェネティクスによるうつ病の分子・細胞基盤 日本神経精神薬理学会プログラム・抄録集. 2015.09; 37回・45回 96. ( ichushi )

  3. 内田周作, 内田周作, 樋口尚子, 山形弘隆, 芳原輝之, 樋口文宏, 渡邉義文: レジリエンスの視点からうつ病の発症・回復の分子メカニズムを理解する 日本神経精神薬理学会プログラム・抄録集. 2015.09; 37回・45回 91. ( ichushi )

  4. 山形弘隆, 内田周作, 芳原輝之, 樋口文宏, 原田健一郎, 松尾幸治, 三國雅彦, 渡邉義文: レクチンアレイを用いたうつ病患者血漿タンパク質の糖鎖解析 日本神経精神薬理学会プログラム・抄録集. 2015.09; 37回・45回 197. ( ichushi )

  5. 樋口文宏, 内田周作, 山形弘隆, 芳原輝之, 樋口尚子, 渡邉義文: うつ様行動と神経可塑性におけるmicroRNA‐124の役割の解析 先進医薬研究振興財団 2014年度 研究成果報告集. 2015; 50-51.

  6. Matsuda Noriyuki, Koyano Fumika: Phos-Tag PAGE: uncovering the role of phosphorylation resisting Parkinson's disease Electrophoresis Letters. 2015; 59 (2): 70-72. ( DOI )

  1. 芳原輝之, 阿部尚子, 内田周作, 山形弘隆, 樋口文宏, 大朏孝治, 渡邉義文: ヒストン脱アセチル化酵素(SIRT1)のうつ状態,抗うつ薬作用機序への関与の検討 精神薬療研究年報. 2014.03; (46): 66-67. ( ichushi )

  2. 山形弘隆, 内田周作, 芳原輝之, 樋口文宏, 渡邉義文: 慢性ストレス負荷BALB/cマウスの海馬における遺伝子発現マイクロアレイ解析 日本生物学的精神医学会誌. 2014; 339.

  1. 大朏孝治, 内田周作, 山形弘隆, 芳原輝之, 渡邉義文: 抗うつ効果の早期発現を実現する薬物治療法の開発 精神薬療研究年報. 2013.03; (45): 73-74. ( ichushi )

  1. Koji Otsuki, Shusaku Uchida, Teruyuki Hobara, Hirotaka Yamagata, Yoshifuini Watanabe: Epigenetic regulation in depression Japanese Journal of Neuropsychopharmacology. 2012.08; 32 (4): 181-186. ( PubMed )

  1. OTSUKI Koji, UCHIDA Shusaku, HOBARA Teruyuki, WATANABE Yoshifumi: Epigenetic regulation in depression 2011.06; 22 (2): 89-95.

  1. 山形弘隆, 内田周作, 渡邉義文: うつ病と神経可塑性に対するBubR1の役割 日本生物学的精神医学会誌. 2010.10; 21 (Supplement): 151.

  2. 柴田朋彦, 山形弘隆, 内田周作, 渡邉義文: アポトーシス制御因子であるBH3‐only proteinのうつ病における役割 日本生物学的精神医学会誌. 2010.10; 21 (Supplement): 153.

  1. Glucocorticoid receptor Japanese journal of molecular psychiatry. 2008.01; 8 (1): 61-64.

  1. 綿貫 俊夫, 船戸 弘正, 内田 周作, 松原 敏郎, 若林 祐介, 大朏 孝治, 西田 朗, 渡邉 義文: 気分障害患者における選択的スプライシング調節機構異常の検討 精神薬療研究年報. 2007.03; (39): 59-65. ( ichushi )

  1. 綿貫 俊夫, 松原 敏郎, 船戸 弘正, 内田 周作, 西田 朗, 渡邉 義文: 気分障害患者におけるグルココルチコイド受容体の発現異常と機能障害の統合的検討 精神薬療研究年報. 2006.03; (38): 146-154. ( ichushi )

  1. Kida S, Uchida S: [Regulation of emotional behavior by nuclear receptors]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 2005.01; 125 (1): 17-24. ( PubMed , DOI )

  1. Toshiro Moroishi, Ayato Maeda, Akihiro Nita, Shoko Sashiyama, Komen Jepkosgei, Yuqing Xu, Yuichiro Arima, Keiichi Nakayama, Kimi Araki, Suzu Yoshitomo: In vivo visualization of bioactive iron and oxygen using the Labile Iron and Oxygen Notifier (LiON) 2025.06; ( DOI )

  2. Toshiro Moroishi, Yudai OHTA, Yohei KANAMORI, Ayato MAEDA, Mohamed Fathi Saleh, Akihiro NITA, Takashi MATSHMOTO, Keiichi I Nakayama: Iron exacerbates congenital cholestatic liver injury via bile acid-induced ferroptosis The American Journal of Pathology. 2025.05; ( PubMed , DOI )

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