Advanced Pathophysiological Science

264  articles.  
* There may be some overlapped articles listed due to the difference of format.

  1. Miwako Sase, Taku Sato, Hajime Sato, Fuyuki Miya, Shicheng Zhang, Hiroshi Haeno, Mihoko Kajita, Tadahide Noguchi, Yoshiyuki Mori, Toshiaki Ohteki: Comparative analysis of tongue cancer organoids among patients identifies the heritable nature of minimal residual disease. Dev Cell. 2025.02; 60 (3): 396-413.e6. ( PubMed , DOI )

  2. Tatsuya Morishima, Md Fakruddin, Yohei Kanamori, Takeshi Masuda, Akiko Ogawa, Yuxin Wang, Vivien A C Schoonenberg, Falk Butter, Yuichiro Arima, Takaaki Akaike, Toshiro Moroishi, Kazuhito Tomizawa, Toshio Suda, Fan-Yan Wei, Hitoshi Takizawa: Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis. Science advances. 2025.02; 11 (8): eadu3011. ( PubMed , DOI )

  3. Fumika Koyano, Noriyuki Matsuda: Quality control of ABCD3 by the VCP-FAF2 complex suppresses excessive pexophagy Autophagy. 2025.02; ( PubMed , DOI )

  4. Pawaret Panyajai, Natsima Viriyaadhammaa, Sawitree Chiampanichayakul, Yasuhisa Sakamoto, Siriporn Okonogi, Toshiro Moroishi, Songyot Anuchapreeda: Anticancer and cancer preventive activities of shogaol and curcumin from Zingiberaceae family plants in KG-1a leukemic stem cells BMC Complementary Medicine and Therapies. 2025.02; 25 (1): ( DOI )

  1. Yumoto Shinsei, Horiguchi Haruki, Kadomatsu Tsuyoshi, Horino Taichi, Sato Michio, Terada Kazutoyo, Miyata Keishi, Moroishi Toshiro, Baba Hideo, Oike Yuichi: Host ANGPTL2 establishes an immunosuppressive tumor microenvironment and resistance to immune checkpoint therapy(タイトル和訳中) Cancer Science. 2024.12; 115 (12): 3846-3858. ( ichushi )

  2. Koyano F, Yamano K, Hoshina T, Kosako H, Fujiki Y, Tanaka K, Matsuda N: AAA+ ATPase chaperone p97/VCP(FAF2) governs basal pexophagy. Nature communications. 2024.10; 15 (1): 9347. ( PubMed , DOI )

  3. Yasuhisa Sakamoto, Akiyoshi Uezu, Koji Kikuchi, Jangmi Kang, Eiko Fujii, Toshiro Moroishi, Shiro Suetsugu, Hiroyuki Nakanishi: The Nedd4L ubiquitin ligase is activated by FCHO2-generated membrane curvature The EMBO Journal. 2024.10; ( DOI )

  4. Chanida Thinyakul, Yasuhisa Sakamoto, Mayuko Shimoda, Yanliang Liu, Suyanee Thongcho, Omnia Reda, Akihiro Nita, Romgase Sakamula, Somponnat Sampattavanich, Ayato Maeda, Paweenapon Chunthaboon, David Nduru, Mayumi Niimura, Yohei Kanamori, Peti Thuwaji, Keiichi I. Nakayama, Kun-Liang Guan, Yorifumi Satou, Chanitra Thuwaji, Toshiro Moroishi: Hippo pathway in cancer cells induces NCAM1+αSMA+ fibroblasts to modulate tumor microenvironment Communications Biology. 2024.10; 7 (1): 1343. ( PubMed , DOI )

  5. Tomoya Yamashita, Haruki Horiguchi, Tsuyoshi Kadomatsu, Michio Sato, Toshiro Moroishi, Yuichi Oike: Immunotherapy-induced reprogramming of cancer-associated fibroblasts can promote tumor progression. Genes to cells : devoted to molecular & cellular mechanisms. 2024.10; ( PubMed , DOI )

  6. Endo R, Kinefuchi H, Sawada M, Kikuchi R, Kojima W, Matsuda N, Yamano K: TBK1 adaptor AZI2/NAP1 regulates NDP52-driven mitochondrial autophagy. The Journal of biological chemistry. 2024.09; 300 (10): 107775. ( PubMed , DOI )

  7. Shinsei Yumoto, Haruki Horiguchi, Tsuyoshi Kadomatsu, Taichi Horino, Michio Sato, Kazutoyo Terada, Keishi Miyata, Toshiro Moroishi, Hideo Baba, Yuichi Oike: Host ANGPTL2 establishes an immunosuppressive tumor microenvironment and resistance to immune checkpoint therapy. Cancer science. 2024.09; ( PubMed , DOI )

  8. Akiyama M, Kanayama M, Umezawa Y, Nagao T, Izumi Y, Yamamoto M, Ohteki T: An early regulatory mechanism of hyperinflammation by restricting monocyte contribution. Frontiers in immunology. 2024.07; 15 1398153. ( PubMed , DOI )

  9. Akiyama M, Kanayama M, Umezawa Y, Nagao T, Izumi Y, Yamamoto M, Ohteki T.: An early regulatory mechanism of hyperinflammation by restricting monocyte contribution Front Immunol.. 2024.07; 15 1398153.

  10. Hao Li, Yohei Kanamori, Toshiro Moroishi: Cell attachment defines sensitivity to cold stress via the Hippo pathway Biochemical and Biophysical Research Communications. 2024.07; 730 150373. ( DOI )

  11. Takayuki Miyamoto, Kazushi Izawa, Sho Masui, Atsue Yamazaki, Yuichi Yamasaki, Tadashi Matsubayashi, Mayuka Shiraki, Hidenori Ohnishi, Junko Yasumura, Tomohiro Kawabe, Takako Miyamae, Tomoyo Matsubara, Naoya Arakawa, Takashi Ishige, Takumi Takizawa, Asami Shimbo, Masaki Shimizu, Naoki Kimura, Yuichi Maeda, Yuta Maruyama, Tomonari Shigemura, Junichi Furuta, Satoshi Sato, Hiroshi Tanaka, Miharu Izumikawa, Masahiro Yamamura, Toshio Hasegawa, Hiroshi Kaneko, Yasuo Nakagishi, Naoko Nakano, Yasunori Iida, Tamaki Nakamura, Hiroyuki Wakiguchi, Takayuki Hoshina, Toshinao Kawai, Kosaku Murakami, Shuji Akizuki, Akio Morinobu, Koichiro Ohmura, Katsuhide Eguchi, Motoshi Sonoda, Masataka Ishimura, Kenji Furuno, Momoko Kashiwado, Masaaki Mori, Kimito Kawahata, Koremasa Hayama, Kumiko Shimoyama, Natsuko Sasaki, Taisuke Ito, Hiroaki Umebayashi, Tae Omori, Seiko Nakamichi, Tomotsune Dohmoto, Yasuyuki Hasegawa, Hisashi Kawashima, Shojiro Watanabe, Yuichiro Taguchi, Haruna Nakaseko, Naomi Iwata, Hiroki Kohno, Taiki Ando, Yasuhiko Ito, Yuko Kataoka, Takako Saeki, Utako Kaneko, Ayako Murase, Seira Hattori, Tomo Nozawa, Kenichi Nishimura, Reiji Nakano, Misa Watanabe, Masato Yashiro, Tomonori Nakamura, Toshihiko Komai, Kentaro Kato, Yoshitaka Honda, Eitaro Hiejima, Atsushi Yonezawa, Kazuhisa Bessho, Satoshi Okada, Osamu Ohara, Junko Takita, Takahiro Yasumi, Ryuta Nishikomori, : Clinical Characteristics of Cryopyrin-Associated Periodic Syndrome and Long-Term Real-World Efficacy and Tolerability of Canakinumab in Japan: Results of a Nationwide Survey. Arthritis Rheumatol. 2024.06; 76 (6): 949-962. ( PubMed , DOI )

  12. Aiko Watanabe, Fumika Koyano, Kenichiro Imai, Yohei Hizukuri, Shizuka Ogiwara, Tomoya Ito, Jun Miyamoto, Chihiro Shibuya, Mayumi Kimura, Kazuya Toriumi, Chie Motono, Makoto Arai, Keiji Tanaka, Yoshinori Akiyama, Koji Yamano, Noriyuki Matsuda: The origin of esterase activity of Parkinson's disease causative factor DJ-1 implied by evolutionary trace analysis of its prokaryotic homolog HchA. J Biol Chem. 2024.06; 300 (7): 107476. ( PubMed , DOI )

  13. Koki Murata, Kai Harayama, Mayuko Shimoda, Mayumi Niimura, Masahiro Wakao, Yasuo Suda, Toshiro Moroishi, Hiroyuki Shinchi: Improvement of the Nuclease Resistance and Immunostimulatory Activity of CpG Oligodeoxynucleotides by Conjugation to Sugar-Immobilized Gold Nanoparticles Bioconjugate Chemistry. 2024.05; 35 (6): 804-815. ( DOI )

  14. Manabu S, Nawa N, Noguchi Y, Taki A, Kashimada A, Honda I, Koyama A, Okazaki K, Kondo M, Miyahara H, Ito K, Yamauchi T, Kondo T, Honda-Ozaki F, Kusuda S, Morioka C, Fujiwara T, Morio T, Kashimada K: Stage III Chorioamnionitis Is Associated with Reduced Risk of Severe Retinopathy of Prematurity. The Journal of pediatrics. 2024.05; 114085. ( PubMed , DOI )

  15. Nita Akihiro, Moroishi Toshiro: 細胞間情報伝達におけるHippo経路　発生と再生において判明しつつある役割(Hippo pathway in cell-cell communication: emerging roles in development and regeneration) Inflammation and Regeneration. 2024.04; 44 s41232-024. ( ichushi )

  16. Akihiro Nita, Toshiro Moroishi: Hippo pathway in cell–cell communication: emerging roles in development and regeneration Inflammation and Regeneration. 2024.04; 44 (1): ( DOI )

  17. Yamano K, Kinefuchi H, Kojima W: Mitochondrial lipid dynamics regulated by MITOL-mediated ubiquitination. Journal of biochemistry. 2024.03; 175 (3): 217-219. ( PubMed , DOI )

  18. Tumor stroma-derived ANGPTL2 potentiates immune checkpoint inhibitor efficacy. 2024.03; ( PubMed , DOI )

  19. Kamii Y, Hayashizaki K, Kanno T, Chiba A, Ikegami T, Saito M, Akeda Y, Ohteki T, Kubo M, Yoshida K, Kawakami K, Oishi K, Araya J, Kuwano K, Kronenberg M, Endo Y, Kinjo Y.: IL-27 regulates the differentiation of follicular helper NKT cells via metabolic adaptation of mitochondria. Proc Natl Acad Sci USA.. 2024.02; 121 e2313964121.

  20. Ohara D, Takeuchi Y, Watanabe H, Lee Y, Mukoyama H, Ohteki T, Kondoh G, Hirota K.: Notch2 with retinoic acid license IL-23 expression by intestinal EpCAM+ DCIR2+ cDC2s in mice J Exp Med.. 2024.02; 221 e20230923.

  21. Cui M, Yamano K, Yamamoto K, Yamamoto-Imoto H, Minami S, Yamamoto T, Matsui S, Kaminishi T, Shima T, Ogura M, Tsuchiya M, Nishino K, Layden BT, Kato H, Ogawa H, Oki S, Okada Y, Isaka Y, Kosako H, Matsuda N, Yoshimori T, Nakamura S: HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence. Proceedings of the National Academy of Sciences of the United States of America. 2024.01; 121 (2): e2306454120. ( PubMed , DOI )

  22. Yamano K, Sawada M, Kikuchi R, Nagataki K, Kojima W, Endo R, Kinefuchi H, Sugihara A, Fujino T, Watanabe A, Tanaka K, Hayashi G, Murakami H, Matsuda N: Optineurin provides a mitophagy contact site for TBK1 activation. The EMBO journal. 2024.01; 43 (5): 754-779. ( PubMed , DOI )

  23. Kawasaki I, Sugiura K, Sasaki T, Matsuda N, Sato M, Sato K: MARC-3, a membrane-associated ubiquitin ligase, is required for fast polyspermy block in Caenorhabditis elegans. Nature communications. 2024.01; 15 (1): 792. ( PubMed , DOI )

  1. Yamano K, Kinefuchi H, Kojima W: Mitochondrial quality control via organelle and protein degradation. Journal of biochemistry. 2023.12; ( PubMed , DOI )

  2. Hinokuma Hironori, Kanamori Yohei, Ikeda Koei, Hao Li, Maruno Masataka, Yamane Taishi, Maeda Ayato, Nita Akihiro, Shimoda Mayuko, Niimura Mayumi, Takeshima Yuki, Li Shuran, Suzuki Makoto, Moroishi Toshiro: 肺癌細胞増殖における第一鉄と第二鉄で異なる機能(Distinct functions between ferrous and ferric iron in lung cancer cell growth) Cancer Science. 2023.11; 114 (11): 4355-4364. ( ichushi )

  3. Shinya Abe, Takuma Asahi, Takahiro Hara, Guangwei Cui, Akihiro Shimba, Shizue Tani-Ichi, Kohei Yamada, Kazuko Miyazaki, Hitoshi Miyachi, Satsuki Kitano, Naotoshi Nakamura, Junichi Kikuta, Alexis Vandenbon, Masaki Miyazaki, Ryo Yamada, Toshiaki Ohteki, Masaru Ishii, Veronika Sexl, Takashi Nagasawa, Koichi Ikuta: Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow. Cell Rep. 2023.09; 42 (9): 113127. ( PubMed , DOI )

  4. Hironori Hinokuma, Yohei Kanamori, Koei Ikeda, Li Hao, Masataka Maruno, Taishi Yamane, Ayato Maeda, Akihiro Nita, Mayuko Shimoda, Mayumi Niimura, Yuki Takeshima, Shuran Li, Makoto Suzuki, Toshiro Moroishi: Distinct functions between ferrous and ferric iron in lung cancer cell growth. Cancer science. 2023.09; ( PubMed , DOI )

  5. Kurusu R, Fujimoto Y, Morishita H, Noshiro D, Takada S, Yamano K, Tanaka H, Arai R, Kageyama S, Funakoshi T, Komatsu-Hirota S, Taka H, Kazuno S, Miura Y, Koike M, Wakai T, Waguri S, Noda NN, Komatsu M: Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex. Developmental cell. 2023.07; 58 (13): 1189-1205.e11. ( PubMed , DOI )

  6. Akari Nakamura, Seiichiro Sakai, Yoshitaka Taketomi, Jun Tsuyama, Yoshimi Miki, Yuichiro Hara, Nobutaka Arai, Yuki Sugiura, Hideya Kawaji, Makoto Murakami, Takashi Shichita: PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke. Neuron. 2023.07; 111 (19): 2995-+. ( PubMed , DOI )

  7. Ziegler-Heitbrock L, Ohteki T, Ginhoux F, Shortman K, Spits H.: Reply to 'Reclassifying plasmacytoid dendritic cells as innate lymphocytes is premature'. Nat Rev Immunol. 2023.05; 23 (5): 338-339.

  8. Seiichiro Sakai, Takashi Shichita: Role of alarmins in poststroke inflammation and neuronal repair. Semin Immunopathol. 2023.05; 45 (3): 427-435. ( PubMed , DOI )

  9. Akabane S, Watanabe K, Kosako H, Yamashita SI, Nishino K, Kato M, Sekine S, Kanki T, Matsuda N, Endo T, Oka T: TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria. Cell reports. 2023.05; 42 (5): 112454. ( PubMed , DOI )

  10. Masashi Kanayama, Yuta Izumi, Megumi Akiyama, Toyoki Hayashi, Koji Atarashi, Axel Roers, Taku Sato, Toshiaki Ohteki: Myeloid-like B cells boost emergency myelopoiesis through IL-10 production during infection. J Exp Med. 2023.04; 220 (4): e20221221. ( PubMed , DOI )

  11. Aiko Watanabe, Hiroyuki Koike, Naoki Kumagami, Shigeki Shimba, Ichiro Manabe, Yumiko Oishi: Arntl deficiency in myeloid cells reduces neutrophil recruitment and delays skeletal muscle repair. Scientific Reports. 2023.04; 13 (1): 6747. ( PubMed , DOI )

  12. Yamano K, Sawada M, Kikuchi R, Nagataki K, Kojima W, Sugihara A, Fujino T, Tanaka K, Hayashi G, Murakami H, Matsuda N. : Optineurin provides a mitophagy contact site for TBK1 activation bioRxiv. 2023.02;

  13. Hayashida R, Kikuchi R, Imai K, Kojima W, Yamada T, Iijima M, Sesaki H, Tanaka K, Matsuda N, Yamano K: Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid-liquid phase separation-based method. The Journal of biological chemistry. 2023.02; 299 (2): 102822. ( PubMed , DOI )

  1. Bu Luke, Yonemura Atsuko, Yasuda-Yoshihara Noriko, Uchihara Tomoyuki, Ismagulov Galym, Takasugi Sanae, Yasuda Tadahito, Okamoto Yuya, Kitamura Fumimasa, Akiyama Takahiko, Arima Kota, Itoyama Rumi, Zhang Jun, Fu Lingfeng, Hu Xichen, Wei Feng, Arima Yuichiro, Moroishi Toshiro, Nishiyama Koichi, Sheng Guojun, Mukunoki Toshifumi, Otani Jun, Baba Hideo, Ishimoto Takatsugu: 腫瘍微小環境における15-PGDHの枯渇は膵臓癌における線維性腫瘍形成と血管新生を促進する(Tumor microenvironmental 15-PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer) Cancer Science. 2022.10; 113 (10): 3579-3592. ( ichushi )

  2. Guangwei Cui, Akihiro Shimba, Jianshi Jin, Taisaku Ogawa, Yukiko Muramoto, Hitoshi Miyachi, Shinya Abe, Takuma Asahi, Shizue Tani-Ichi, Johannes M Dijkstra, Yayoi Iwamoto, Kirill Kryukov, Yuanbo Zhu, Daichi Takami, Takahiro Hara, Satsuki Kitano, Yan Xu, Hajime Morita, Moyu Zhang, Lynn Zreka, Keishi Miyata, Takashi Kanaya, Shinya Okumura, Takashi Ito, Etsuro Hatano, Yoshimasa Takahashi, Hiroshi Watarai, Yuichi Oike, Tadashi Imanishi, Hiroshi Ohno, Toshiaki Ohteki, Nagahiro Minato, Masato Kubo, Georg A Holländer, Hideki Ueno, Takeshi Noda, Katsuyuki Shiroguchi, Koichi Ikuta: A circulating subset of iNKT cells mediates antitumor and antiviral immunity. Sci Immunol. 2022.10; 7 (76): eabj8760. ( PubMed , DOI )

  3. Loems Ziegler-Heitbrock, Toshiaki Ohteki, Florent Ginhoux, Ken Shortman, Hergen Spits: Reclassifying plasmacytoid dendritic cells as innate lymphocytes. Nat Rev Immunol. 2022.10; 23 (1): 1-2. ( PubMed , DOI )

  4. Taishi Yamane, Yohei Kanamori, Hiroshi Sawayama, Hiromu Yano, Akihiro Nita, Yudai Ohta, Hironori Hinokuma, Ayato Maeda, Akiko Iwai, Takashi Matsumoto, Mayuko Shimoda, Mayumi Niimura, Shingo Usuki, Noriko Yasuda-Yoshihara, Masato Niwa, Yoshifumi Baba, Takatsugu Ishimoto, Yoshihiro Komohara, Tomohiro Sawa, Tasuku Hirayama, Hideo Baba, Toshiro Moroishi: Iron accelerates Fusobacterium nucleatum-induced CCL8 expression in macrophages and is associated with colorectal cancer progression JCI Insight. 2022.09; 7 (21): ( PubMed , DOI )

  5. Sonn I, Honda-Ozaki F, Yoshimatsu S, Morimoto S, Watanabe H, Okano H: Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia. Inflammation and regeneration. 2022.07; 42 (1): 20. ( PubMed , DOI )

  6. Haruki Horiguchi, Tsuyoshi Kadomatsu, Shinsei Yumoto, Takeshi Masuda, Keishi Miyata, Shuji Yamamura, Michio Sato, Jun Morinaga, Sumio Ohtsuki, Hideo Baba, Toshiro Moroishi, Yuichi Oike: Tumor cell-derived ANGPTL2 promotes β-catenin-driven intestinal tumorigenesis Oncogene. 2022.07; 41 (33): 4028-4041. ( PubMed , DOI )

  7. Luke Bu, Atsuko Yonemura, N. Yasuda‐Yoshihara, Tomoyuki Uchihara, Galym Ismagulov, Sanae Takasugi, Tadahito Yasuda, Yuya Okamoto, Fumimasa Kitamura, Takahiko Akiyama, Kota Arima, Rumi Itoyama, Jun Zhang, Lingfeng Fu, Xichen Hu, Feng Wei, Yuichiro Arima, Toshiro Moroishi, Koichi Nishiyama, Guojun Sheng, Toshifumi Mukunoki, Jun Otani, Hideo Baba, Takatsugu Ishimoto: Tumor microenvironmental 15‐PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer Cancer Science. 2022.07; 113 (10): 3579-3592. ( PubMed , DOI )

  8. Sonn Iki, Honda-Ozaki Fumiko, Yoshimatsu Sho, Morimoto Satoru, Watanabe Hirotaka, Okano Hideyuki: 一つの転写因子が高い効率でヒト人工多能性幹細胞を機能性ミクログリアに誘導する(Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia) Inflammation and Regeneration. 2022.06; 42 1 of 20-20 of 20. ( ichushi )

  9. Hiroyuki Shinchi, Fumikazu Komaki, Masaharu Yuki, Haruka Ohara, Naohiro Hayakawa, Masahiro Wakao, Howard B. Cottam, Tomoko Hayashi, Dennis A. Carson, Toshiro Moroishi, Yasuo Suda: Glyco-Nanoadjuvants: Impact of Linker Length for Conjugating a Synthetic Small-Molecule TLR7 Ligand to Glyco-Nanoparticles on Immunostimulatory Effects ACS Chemical Biology. 2022.03; 17 (4): 957-968. ( DOI )

  10. Daichi Nomoto, Yoshifumi Baba, Yang Liu, Hiroyasu Tsutsuki, Kazuo Okadome, Kazuto Harada, Takatsugu Ishimoto, Masaaki Iwatsuki, Shiro Iwagami, Yuji Miyamoto, Naoya Yoshida, Masayuki Watanabe, Toshiro Moroishi, Yoshihiro Komohara, Tomohiro Sawa, Hideo Baba: Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression via the NOD1/RIPK2/NF-κB pathway Cancer Letters. 2022.01; 530 59-67. ( PubMed , DOI )

  11. Le Yu, Dan Zhou, Guiming Zhang, Zhonglu Ren, Xin Luo, Peng Liu, Steven W. Plouffe, Zhipeng Meng, Toshiro Moroishi, Yilei Li, Yiyue Zhang, Joan Heller Brown, Shuwen Liu, Kun‐Liang Guan: Co‐occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence Molecular Oncology. 2022; ( DOI )

  1. Adachi A, Honda T, Dainichi T, Egawa G, Yamamoto Y, Nomura T, Nakajima S, Otsuka A, Maekawa M, Mano N, Koyanagi N, Kawaguchi Y, Ohteki T, Nagasawa T, Ikuta K, Kitoh A, Kabashima K.: Prolonged high-intensity exercise induces fluctuating immune responses to herpes simplex virus infection via glucocorticoids. J Allergy Clin Immunol. 2021.12;

  2. Bruno Barros Queliconi, Waka Kojima, Mayumi Kimura, Kenichiro Imai, Chisato Udagawa, Chie Motono, Takatsugu Hirokawa, Shinya Tashiro, Jose M M Caaveiro, Kouhei Tsumoto, Koji Yamano, Keiji Tanaka, Noriyuki Matsuda: Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-1. J Cell Sci. 2021.11; 134 (22): jcs258653. ( PubMed , DOI )

  3. Ohteki T, Kawamura S, Onai N.: Commitment to dendritic cells and monocytes. Int Immunol.. 2021.11;

  4. Yamano K, Kojima W: Molecular functions of autophagy adaptors upon ubiquitin-driven mitophagy. Biochimica et biophysica acta. General subjects. 2021.10; 1865 (10): 129972. ( PubMed , DOI )

  5. Waka Kojima, Koji Yamano, Hidetaka Kosako, Kenichiro Imai, Reika Kikuchi, Keiji Tanaka, Noriyuki Matsuda: Mammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy. Autophagy. 2021.08; 17 (8): 2011-2036. ( PubMed , DOI )

  6. Yukiko Yoshida, Makoto Asahina, Arisa Murakami, Junko Kawawaki, Meari Yoshida, Reiko Fujinawa, Kazuhiro Iwai, Ryuichi Tozawa, Noriyuki Matsuda, Keiji Tanaka, Tadashi Suzuki: Loss of peptide N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase. Proc Natl Acad Sci U S A. 2021.07; 118 (27): e2102902118. ( PubMed , DOI )

  7. Taiki Baba, Susumu Tanimura, Ayane Yamaguchi, Koichiro Horikawa, Masashi Yokozeki, Saki Hachiya, Shun-Ichiro Iemura, Tohru Natsume, Noriyuki Matsuda, Kohsuke Takeda: Cleaved PGAM5 dephosphorylates nuclear serine/arginine-rich proteins during mitophagy. Biochim Biophys Acta Mol Cell Res. 2021.07; 1868 (7): 119045. ( PubMed , DOI )

  8. ANXious for YAP 2021.07; ( DOI )

  9. Koutarou Nakamura, Seiichiro Sakai, Jun Tsuyama, Akari Nakamura, Kento Otani, Kumiko Kurabayashi, Yoshiko Yogiashi, Hisao Masai, Takashi Shichita: Extracellular DJ-1 induces sterile inflammation in the ischemic brain. PLoS Biol. 2021.05; 19 (5): e3000939. ( PubMed , DOI )

  10. Kase, N; Terashima, M; Ohta, A; Niwa, A; Honda-Ozaki, F; Kawasaki, Y; Nakahata, T; Kanazawa, N; Saito, MK: Pluripotent stem cell-based screening identifiesCUDC-907 as an effective compound for restoring the in vitro phenotype ofNakajo-Nishimurasyndrome STEM CELLS TRANSLATIONAL MEDICINE. 2021.03; 10 (3): 455-464. ( PubMed , DOI )

  11. Hiroyuki Shinchi, Masaharu Yuki, Takayoshi Yamauchi, Mayumi Niimura, Masahiro Wakao, Howard B. Cottam, Tomoko Hayashi, Dennis A. Carson, Toshiro Moroishi, Yasuo Suda: Glyco-Nanoadjuvants: Sugar Structures on Carriers of a Small Molecule TLR7 Ligand Affect Their Immunostimulatory Activities ACS Applied Bio Materials. 2021.03; 4 (3): 2732-2741. ( DOI )

  12. Chikuma S, Yamanaka S, Nakagawa S, Ueda MT, Hayabuchi H, Tokifuji Y, Kanayama M, Okamura T, Arase H, Yoshimura A: TRIM28 Expression on Dendritic Cells Prevents Excessive T Cell Priming by Silencing Endogenous Retrovirus. Journal of immunology (Baltimore, Md. : 1950). 2021.02; 206 (7): 1528-1539. ( PubMed , DOI )

  13. Izumi Y, Kanayama M, Shen Z, Kai M, Kawamura S, Akiyama M, Yamamoto M, Nagao T, Okada K, Kawamata N, Toyota S, Ohteki T: An Antibody-Drug Conjugate That Selectively Targets Human Monocyte Progenitors for Anti-Cancer Therapy. Frontiers in immunology. 2021.02; 12 618081. ( PubMed , DOI )

  14. Mashun Onishi, Koji Yamano, Miyuki Sato, Noriyuki Matsuda, Koji Okamoto: Molecular mechanisms and physiological functions of mitophagy. EMBO J. 2021.02; 40 (3): e104705. ( PubMed , DOI )

  15. Yamauchi Takayoshi, Moroishi Toshiro: 腫瘍免疫における腫瘍由来細胞外小胞の陰と陽(【Medical chemistry of extracellular vesicles】The Yin and Yang of tumour-derived extracellular vesicles in tumour immunity) The Journal of Biochemistry. 2021.02; 169 (2): 155-161. ( ichushi )

  16. Izumi Y, Kanayama M, Shen Z, Kai M, Kawamura S, Akiyama M, Yamamoto M, Nagao T, Okada K, Kawamata N, Toyota S, Ohteki T.: An Antibody-Drug Conjugate That Selectively Targets Human Monocyte Progenitors for Anti-Cancer Therapy. Front Immunol.. 2021.02; 12 618081..

  17. The Yin and Yang of tumour-derived extracellular vesicles in tumour immunity 2021; ( DOI )

  1. Heat stress activates YAP/TAZ to induce the heat shock transcriptome 2020.12; 22 (12): 1447-1459. ( DOI )

  2. Yamano K, Youle RJ: Two different axes CALCOCO2-RB1CC1 and OPTN-ATG9A initiate PRKN-mediated mitophagy. Autophagy. 2020.11; 16 (11): 2105-2107. ( PubMed , DOI )

  3. Haruki Horiguchi, Tsuyoshi Kadomatsu, Keishi Miyata, Kazutoyo Terada, Michio Sato, Daisuke Torigoe, Jun Morinaga, Toshiro Moroishi, Yuichi Oike: Stroma-derived ANGPTL2 establishes an anti-tumor microenvironment during intestinal tumorigenesis Oncogene. 2020.10; ( DOI )

  4. Matsuda N, Yamano K: Two sides of a coin: Physiological significance and molecular mechanisms for damage-induced mitochondrial localization of PINK1 and Parkin. Neuroscience research. 2020.10; 159 16-24. ( PubMed , DOI )

  5. Kana Minamide, Taku Sato, Yusuke Nakanishi, Hiroshi Ohno, Tamotsu Kato, Jumpei Asano, Toshiaki Ohteki: IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon. Sci Rep. 2020.09; 10 (1): 14639. ( PubMed , DOI )

  6. Kanayama M, Izumi Y, Yamauchi Y, Kuroda S, Shin T, Ishikawa S, Sato T, Kajita M, Ohteki T.: CD86-based analysis enables observation of bona fide hematopoietic responses Blood.. 2020.09; 136 (10): 1144-1154.

  7. Koji Yamano, Reika Kikuchi, Waka Kojima, Ryota Hayashida, Fumika Koyano, Junko Kawawaki, Takuji Shoda, Yosuke Demizu, Mikihiko Naito, Keiji Tanaka, Noriyuki Matsuda: Critical role of mitochondrial ubiquitination and the OPTN ATG9A axis in mitophagy Journal of Cell Biology. 2020.09; 219 (9): ( PubMed , DOI )

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  7. Shinchi, H, Yamaguchi, T, Moroishi, T, Yuki, M, Wakao, M, Hayashi, T, Cottam, H.B, Carson, D.A, Suda, Y: Gold nanoparticles co-immobilized with small molecule toll-like receptor 7 ligand and α-mannose as adjuvants Bioconjugate Chem.. 2019.10; 30 2811-2821. ( DOI )

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  14. Zi Wang, Soichiro Adachi, Lingling Kong, Daisuke Watanabe, Yusuke Nakanishi, Toshiaki Ohteki, Namiko Hoshi, Yuzo Kodama: Role of eosinophils in a murine model of inflammatory bowel disease. Biochem. Biophys. Res. Commun.. 2019.03; 511 (1): 99-104. ( PubMed , DOI )

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  2. Tsutomu Endo, Koyu Ito, Junko Morimoto, Masashi Kanayama, Daichi Ota, Masahiro Ikesue, Shigeyuki Kon, Daisuke Takahashi, Tomohiro Onodera, Norimasa Iwasaki, Toshimitsu Uede: Syndecan 4 Regulation of the Development of Autoimmune Arthritis in Mice by Modulating B Cell Migration and Germinal Center Formation. Arthritis & rheumatology (Hoboken, N.J.). 2015.09; 67 (9): 2512-2522. ( PubMed , DOI )

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  1. Daichi Ota, Masashi Kanayama, Yutaka Matsui, Koyu Ito, Naoyoshi Maeda, Goro Kutomi, Koichi Hirata, Toshihiko Torigoe, Noriyuki Sato, Akinori Takaoka, Ann F Chambers, Junko Morimoto, Toshimitsu Uede: Tumor-α9β1 integrin-mediated signaling induces breast cancer growth and lymphatic metastasis via the recruitment of cancer-associated fibroblasts. J. Mol. Med.. 2014.12; 92 (12): 1271-1281. ( PubMed , DOI )

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  5. Tsuyoshi Asano, Norimasa Iwasaki, Shigeyuki Kon, Masashi Kanayama, Junko Morimoto, Akio Minami, Toshimitsu Uede: α9β1 integrin acts as a critical intrinsic regulator of human rheumatoid arthritis. Rheumatology (Oxford). 2014.03; 53 (3): 415-424. ( PubMed , DOI )

  1. Takayuki Sato, Toshio Kitawaki, Haruyuki Fujita, Makoto Iwata, Tomonori Iyoda, Kayo Inaba, Toshiaki Ohteki, Suguru Hasegawa, Kenji Kawada, Yoshiharu Sakai, Hiroki Ikeuchi, Hiroshi Nakase, Akira Niwa, Akifumi Takaori-Kondo, Norimitsu Kadowaki: Human CD1c⁺ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D₃. J Immunol. 2013.09; 191 (6): 3152-3160. ( PubMed , DOI )

  2. Hideaki Ohyagi, Nobuyuki Onai, Taku Sato, Satoshi Yotsumoto, Jiajia Liu, Hisaya Akiba, Hideo Yagita, Koji Atarashi, Kenya Honda, Axel Roers, Werner Müller, Kazutaka Kurabayashi, Mayuka Hosoi-Amaike, Naoto Takahashi, Makoto Hirokawa, Kouji Matsushima, Kenichi Sawada, Toshiaki Ohteki: Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses. Immunity. 2013.09; 39 (3): 584-598. ( PubMed , DOI )

  3. Atsushi Hayashi, Toshiro Sato, Nobuhiko Kamada, Yohei Mikami, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Toshifumi Hibi, Axel Roers, Hideo Yagita, Toshiaki Ohteki, Akihiko Yoshimura, Takanori Kanai: A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice. Cell Host Microbe. 2013.06; 13 (6): 711-722. ( PubMed , DOI )

  4. Nobuyuki Onai, Kazutaka Kurabayashi, Mayuka Hosoi-Amaike, Noriko Toyama-Sorimachi, Kouji Matsushima, Kayo Inaba, Toshiaki Ohteki: A clonogenic progenitor with prominent plasmacytoid dendritic cell developmental potential. Immunity. 2013.05; 38 (5): 943-957. ( PubMed , DOI )

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  7. Hiroyuki Ohta, Seiichiro Sakai, Shin Ito, Toru Ishizuka, Yugo Fukazawa, Takehito Kemuriyama, Megumi Tandai-Hiruma, Hajime Mushiake, Yoshiaki Sato, Hiromu Yawo, Yasuhiro Nishida: Paired stimulation between CA3 and CA1 alters excitability of CA3 in the rat hippocampus. Neurosci Lett. 2013.02; 534 182-187. ( PubMed , DOI )

  8. Keiko Umeda, Wataru Shoji, Seiichiro Sakai, Akira Muto, Koichi Kawakami, Toru Ishizuka, Hiromu Yawo: Targeted expression of a chimeric channelrhodopsin in zebrafish under regulation of Gal4-UAS system. Neurosci Res. 2013.01; 75 (1): 69-75. ( PubMed , DOI )

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  10. Akihiko Ichikawa, Keiji Kuba, Masayuki Morita, Shinsuke Chida, Hiroyuki Tezuka, Hiromitsu Hara, Takehiko Sasaki, Toshiaki Ohteki, V Marco Ranieri, Claudia C dos Santos, Yoshihiro Kawaoka, Shizuo Akira, Andrew D Luster, Bao Lu, Josef M Penninger, Stefan Uhlig, Arthur S Slutsky, Yumiko Imai: CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am J Respir Crit Care Med. 2013.01; 187 (1): 65-77. ( PubMed , DOI )

  1. Yoshifumi Abe, Masaki Sekino, Yasushi Terazono, Hiroyuki Ohsaki, Yugo Fukazawa, Seiichiro Sakai, Hiromu Yawo, Tatsuhiro Hisatsune: Opto-fMRI analysis for exploring the neuronal connectivity of the hippocampal formation in rats. Neurosci Res. 2012.12; 74 (3-4): 248-255. ( PubMed , DOI )

  2. Jiajia Liu, Yong-Mei Guo, Makoto Hirokawa, Keiko Iwamoto, Kumi Ubukawa, Yoshihiro Michishita, Naohito Fujishima, Hiroyuki Tagawa, Naoto Takahashi, Weiguo Xiao, Junsuke Yamashita, Toshiaki Ohteki, Kenichi Sawada: A synthetic double-stranded RNA, poly I:C, induces a rapid apoptosis of human CD34(+) cells. Exp Hematol. 2012.04; 40 (4): 330-341. ( PubMed , DOI )

  3. Keiko Danzaki, Yutaka Matsui, Masahiro Ikesue, Daichi Ohta, Koyu Ito, Masashi Kanayama, Daisuke Kurotaki, Junko Morimoto, Yoichiro Iwakura, Hideo Yagita, Hiroyuki Tsutsui, Toshimitsu Uede: Interleukin-17A deficiency accelerates unstable atherosclerotic plaque formation in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol.. 2012.02; 32 (2): 273-280. ( PubMed , DOI )

  4. Yukinori Tsukuda, Norimasa Iwasaki, Naoki Seito, Masashi Kanayama, Naoki Fujitani, Yasuro Shinohara, Yasuhiko Kasahara, Tomohiro Onodera, Koji Suzuki, Tsuyoshi Asano, Akio Minami, Tadashi Yamashita: Ganglioside GM3 has an essential role in the pathogenesis and progression of rheumatoid arthritis. PLoS ONE. 2012.01; 7 (6): e40136. ( PubMed , DOI )

  1. Masashi Kanayama, Junko Morimoto, Yutaka Matsui, Masahiro Ikesue, Keiko Danzaki, Daisuke Kurotaki, Koyu Ito, Toshimichi Yoshida, Toshimitsu Uede: α9β1 integrin-mediated signaling serves as an intrinsic regulator of pathogenic Th17 cell generation. J. Immunol.. 2011.12; 187 (11): 5851-5864. ( PubMed , DOI )

  2. Hirosato Mashima, Taku Sato, Yasuo Horie, Yuko Nakagawa, Itaru Kojima, Toshiaki Ohteki, Hirohide Ohnishi: Interferon regulatory factor-2 regulates exocytosis mechanisms mediated by SNAREs in pancreatic acinar cells. Gastroenterology. 2011.09; 141 (3): 1102-1113.e1. ( PubMed , DOI )

  3. 樗木俊聡: 腸管粘膜における樹状細胞の役割(The Role of dendritic cells in the intestinal mucosa) 日本耳鼻咽喉科学会会報　114. 2011.06; 107-113.

  4. Hiroyuki Tezuka, Yukiko Abe, Jumpei Asano, Taku Sato, Jiajia Liu, Makoto Iwata, Toshiaki Ohteki: Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction. Immunity. 2011.02; 34 (2): 247-257. ( PubMed , DOI )

  5. Daisuke Kurotaki, Shigeyuki Kon, Kyeonghwa Bae, Koyu Ito, Yutaka Matsui, Yosuke Nakayama, Masashi Kanayama, Chiemi Kimura, Yoshinori Narita, Takashi Nishimura, Kazuya Iwabuchi, Matthias Mack, Nico van Rooijen, Shimon Sakaguchi, Toshimitsu Uede, Junko Morimoto: CSF-1-dependent red pulp macrophages regulate CD4 T cell responses. J. Immunol.. 2011.02; 186 (4): 2229-2237. ( PubMed , DOI )

  1. Yoshitake Kanazawa, Yasuyuki Saito, Yana Supriatna, Hiroyuki Tezuka, Takenori Kotani, Yoji Murata, Hideki Okazawa, Hiroshi Ohnishi, Yoshitaka Kinouchi, Yoshihisa Nojima, Toshiaki Ohteki, Tooru Shimosegawa, Takashi Matozaki: Role of SIRPα in regulation of mucosal immunity in the intestine. Genes Cells. 2010.12; 15 (12): 1189-1200. ( PubMed , DOI )

  2. Hiroyuki Tezuka, Toshiaki Ohteki: A gas governing mucosal immunity. Vaccine. 2010.11; 28 (50): 8039-8040. ( PubMed , DOI )

  3. Yong-Mei Guo, Keiko Ishii, Makoto Hirokawa, Hiroyuki Tagawa, Hideaki Ohyagi, Yoshihiro Michishita, Kumi Ubukawa, Junsuke Yamashita, Toshiaki Ohteki, Nobuyuki Onai, Kazuyoshi Kawakami, Weiguo Xiao, Kenichi Sawada: CpG-ODN 2006 and human parvovirus B19 genome consensus sequences selectively inhibit growth and development of erythroid progenitor cells. Blood. 2010.06; 115 (22): 4569-4579. ( PubMed , DOI )

  4. Hiroyuki Tezuka, Toshiaki Ohteki: Regulation of intestinal homeostasis by dendritic cells. Immunol Rev. 2010.03; 234 (1): 247-258. ( PubMed , DOI )

  5. Jumpei Asano, Hiroyuki Tada, Nobuyuki Onai, Taku Sato, Yasuo Horie, Yukari Fujimoto, Koichi Fukase, Akira Suzuki, Tak W Mak, Toshiaki Ohteki: Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo. J Immunol. 2010.01; 184 (2): 736-745. ( PubMed , DOI )

  1. Takayuki Tomita, Takanori Kanai, Teruji Totsuka, Yasuhiro Nemoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Naoya Sakamoto, Toshiaki Ohteki, Toshifumi Hibi, Mamoru Watanabe: IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis. Eur J Immunol. 2009.10; 39 (10): 2737-2747. ( PubMed , DOI )

  2. Masashi Kanayama, Daisuke Kurotaki, Junko Morimoto, Tsuyoshi Asano, Yutaka Matsui, Yosuke Nakayama, Yoshinari Saito, Koyu Ito, Chiemi Kimura, Norimasa Iwasaki, Koji Suzuki, Tanenobu Harada, Hong Mei Li, Jun Uehara, Tadaaki Miyazaki, Akio Minami, Shigeyuki Kon, Toshimitsu Uede: Alpha9 integrin and its ligands constitute critical joint microenvironments for development of autoimmune arthritis. J. Immunol.. 2009.06; 182 (12): 8015-8025. ( PubMed , DOI )

  3. Taku Sato, Nobuyuki Onai, Hiroki Yoshihara, Fumio Arai, Toshio Suda, Toshiaki Ohteki: Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. Nat Med. 2009.06; 15 (6): 696-700. ( PubMed , DOI )

  4. Jun Yamada, Junji Hamuro, Atsuki Fukushima, Toshiaki Ohteki, Kazuto Terai, Yoichiro Iwakura, Hideo Yagita, Shigeru Kinoshita: MHC-matched corneal allograft rejection in an IFN-gamma/IL-17-independent manner in C57BL/6 mice. Invest Ophthalmol Vis Sci. 2009.05; 50 (5): 2139-2146. ( PubMed , DOI )

  5. Koyu Ito, Shigeyuki Kon, Yosuke Nakayama, Daisuke Kurotaki, Yoshinari Saito, Masashi Kanayama, Chiemi Kimura, Hongyan Diao, Junko Morimoto, Yutaka Matsui, Toshimitsu Uede: The differential amino acid requirement within osteopontin in alpha4 and alpha9 integrin-mediated cell binding and migration. Matrix Biol.. 2009.01; 28 (1): 11-19. ( PubMed , DOI )

  1. Fumi Miyagawa, Yutaka Tagaya, Brian S Kim, Hiral J Patel, Kazuto Ishida, Toshiaki Ohteki, Thomas A Waldmann, Stephen I Katz: IL-15 serves as a costimulator in determining the activity of autoreactive CD8 T cells in an experimental mouse model of graft-versus-host-like disease. J Immunol. 2008.07; 181 (2): 1109-1119. ( PubMed )

  2. Shoko Kuroda, Miki Nishio, Takehiko Sasaki, Yasuo Horie, Koichi Kawahara, Masato Sasaki, Miyuki Natsui, Takashi Matozaki, Hiroyuki Tezuka, Toshiaki Ohteki, Irmgard Förster, Tak W Mak, Toru Nakano, Akira Suzuki: Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages. Eur J Immunol. 2008.05; 38 (5): 1331-1340. ( PubMed , DOI )

  3. Magali Terme, Nathalie Chaput, Behazine Combadiere, Averil Ma, Toshiaki Ohteki, Laurence Zitvogel: Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells. J Immunol. 2008.04; 180 (7): 4679-4686. ( PubMed )

  4. Kentaro Matsuzaki, Kenichi Miyazaki, Seiichiro Sakai, Hiromu Yawo, Norihito Nakata, Shigeki Moriguchi, Kohji Fukunaga, Akihito Yokosuka, Yutaka Sashida, Yoshihiro Mimaki, Tohru Yamakuni, Yasushi Ohizumi: Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus. Eur J Pharmacol. 2008.01; 578 (2-3): 194-200. ( PubMed , DOI )

  1. Yoshinari Saito, Shigeyuki Kon, Yukio Fujiwara, Yosuke Nakayama, Daisuke Kurotaki, Naoki Fukuda, Chiemi Kimura, Masashi Kanayama, Koyu Ito, Hongyan Diao, Yutaka Matsui, Yasuo Komatsu, Eiko Ohtsuka, Toshimitsu Uede: Osteopontin small interfering RNA protects mice from fulminant hepatitis. Hum. Gene Ther.. 2007.12; 18 (12): 1205-1214. ( PubMed , DOI )

  2. Nobuyuki Onai, Aya Obata-Onai, Michael A Schmid, Toshiaki Ohteki, David Jarrossay, Markus G Manz: Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol. 2007.11; 8 (11): 1207-1216. ( PubMed , DOI )

  3. Toshiaki Ohteki: The dynamics of dendritic cell: mediated innate immune regulation. Allergol Int. 2007.09; 56 (3): 209-214. ( PubMed , DOI )

  4. Hiroyuki Tezuka, Yukiko Abe, Makoto Iwata, Hajime Takeuchi, Hiromichi Ishikawa, Masayuki Matsushita, Tetsuo Shiohara, Shizuo Akira, Toshiaki Ohteki: Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells. Nature. 2007.08; 448 (7156): 929-933. ( PubMed , DOI )

  5. Hiroyuki Kishimoto, Toshiaki Ohteki, Nobuyuki Yajima, Koichi Kawahara, Miyuki Natsui, Satoru Kawarasaki, Koichi Hamada, Yasuo Horie, Yoshiaki Kubo, Seiji Arase, Masaru Taniguchi, Bart Vanhaesebroeck, Tak Wah Mak, Toru Nakano, Shigeo Koyasu, Takehiko Sasaki, Akira Suzuki: The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells. Blood. 2007.04; 109 (8): 3316-3324. ( PubMed , DOI )

  1. Toshiaki Ohteki, Hiroyuki Tada, Kazuto Ishida, Taku Sato, Chikako Maki, Taketo Yamada, Junji Hamuro, Shigeo Koyasu: Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo. J Exp Med. 2006.10; 203 (10): 2329-2338. ( PubMed , DOI )

  2. Seiichi Kuwajima, Taku Sato, Kazuto Ishida, Hiroyuki Tada, Hiroyuki Tezuka, Toshiaki Ohteki: Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation. Nat Immunol. 2006.07; 7 (7): 740-746. ( PubMed , DOI )

  3. Noriko Kitanaka, Yuji Owada, Ryuhei Okuyama, Hiroyuki Sakagami, Mohammad Reza Nourani, Setsuya Aiba, Hiroshi Furukawa, Makoto Watanabe, Masao Ono, Toshiaki Ohteki, Hisatake Kondo: Epidermal-type fatty acid binding protein as a negative regulator of IL-12 production in dendritic cells. Biochem Biophys Res Commun. 2006.06; 345 (1): 459-466. ( PubMed , DOI )

  1. Hiroyuki Tada, Setsuya Aiba, Ken-Ichiro Shibata, Toshiaki Ohteki, Haruhiko Takada: Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells. Infect Immun. 2005.12; 73 (12): 7967-7976. ( PubMed , DOI )

  1. Kenya Honda, Shinya Sakaguchi, Chigusa Nakajima, Ai Watanabe, Hideyuki Yanai, Misako Matsumoto, Toshiaki Ohteki, Tsuneyasu Kaisho, Akinori Takaoka, Shizuo Akira, Tsukasa Seya, Tadatsugu Taniguchi: Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc Natl Acad Sci USA. 2003.09; 100 (19): 10872-10877. ( PubMed , DOI )

  2. Kaisa Holmberg, Sanjeev Mariathasan, Toshiaki Ohteki, Pamela S Ohashi, Nicholas R J Gascoigne: TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCR. J Immunol. 2003.09; 171 (5): 2427-2434. ( PubMed )

  3. Toshimasa Yamauchi, Junji Kamon, Yusuke Ito, Atsushi Tsuchida, Takehiko Yokomizo, Shunbun Kita, Takuya Sugiyama, Makoto Miyagishi, Kazuo Hara, Masaki Tsunoda, Koji Murakami, Toshiaki Ohteki, Shoko Uchida, Sato Takekawa, Hironori Waki, Nelson H Tsuno, Yoichi Shibata, Yasuo Terauchi, Philippe Froguel, Kazuyuki Tobe, Shigeo Koyasu, Kazunari Taira, Toshio Kitamura, Takao Shimizu, Ryozo Nagai, Takashi Kadowaki: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003.06; 423 (6941): 762-769. ( PubMed , DOI )

  4. Harumi Suzuki, Satoshi Matsuda, Yasuo Terauchi, Mari Fujiwara, Toshiaki Ohteki, Tomoichiro Asano, Timothy W Behrens, Taku Kouro, Kiyoshi Takatsu, Takashi Kadowaki, Shigeo Koyasu: PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction. Nat Immunol. 2003.03; 4 (3): 280-286. ( PubMed , DOI )

  5. Samuel D Saibil, Toshiaki Ohteki, Forest M White, Mark Luscher, Arsen Zakarian, Alisha Elford, Jeffery Shabanowitz, Hiroshi Nishina, Patrice Hugo, Josef Penninger, Brian Barber, Donald F Hunt, Pamela S Ohashi: Weak agonist self-peptides promote selection and tuning of virus-specific T cells. Eur J Immunol. 2003.03; 33 (3): 685-696. ( PubMed , DOI )

  1. Yukie Murata, Toshiaki Ohteki, Shigeo Koyasu, Junji Hamuro: IFN-gamma and pro-inflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension. Eur J Immunol. 2002.10; 32 (10): 2866-2873. ( PubMed , DOI )

  2. Toshiaki Ohteki: Critical role for IL-15 in innate immunity. Curr Mol Med. 2002.06; 2 (4): 371-380. ( PubMed )

  3. Kristine M Garza, Kim J McKall-Faienza, Toshiaki Otheki, Arsen Zakarian, Bernhard Odermatt, Pamela S Ohashi: Enhanced T cell responses contribute to the genetic predisposition of CD8-mediated spontaneous autoimmunity. Eur J Immunol. 2002.03; 32 (3): 885-894. ( PubMed , DOI )

  1. T Ohteki, K Suzue, C Maki, T Ota, S Koyasu: Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response. Nat Immunol. 2001.12; 2 (12): 1138-1143. ( PubMed , DOI )

  2. T Ohteki, C Maki, S Koyasu: Overexpression of Bcl-2 differentially restores development of thymus-derived CD4-8+ T cells and intestinal intraepithelial T cells in IFN-regulatory factor-1-deficient mice. J Immunol. 2001.06; 166 (11): 6509-6513. ( PubMed )

  3. A Suzuki, M T Yamaguchi, T Ohteki, T Sasaki, T Kaisho, Y Kimura, R Yoshida, A Wakeham, T Higuchi, M Fukumoto, T Tsubata, P S Ohashi, S Koyasu, J M Penninger, T Nakano, T W Mak: T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity. 2001.05; 14 (5): 523-534. ( PubMed )

  4. T Ohteki, S Koyasu: Role of antigen-presenting cells in innate immune system. Arch Immunol Ther Exp (Warsz.). 2001.01; 49 Suppl 1 S47-S52. ( PubMed )

  1. T Ohteki, M Parsons, A Zakarian, R G Jones, L T Nguyen, J R Woodgett, P S Ohashi: Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3. J Exp Med. 2000.07; 192 (1): 99-104. ( PubMed )

  1. T Ohteki, A Hessel, M F Bachmann, A Zakarian, E Sebzda, M S Tsao, K McKall-Faienza, B Odermatt, P S Ohashi: Identification of a cross-reactive self ligand in virus-mediated autoimmunity. Eur J Immunol. 1999.09; 29 (9): 2886-2896. ( PubMed , DOI )

  2. T Ohteki, T Fukao, K Suzue, C Maki, M Ito, M Nakamura, S Koyasu: Interleukin 12-dependent interferon gamma production by CD8alpha+ lymphoid dendritic cells. J Exp Med. 1999.06; 189 (12): 1981-1986. ( PubMed )

  3. T Ohteki, C Maki, S Koyasu, T W Mak, P S Ohashi: Cutting edge: LFA-1 is required for liver NK1.1+TCR alpha beta+ cell development: evidence that liver NK1.1+TCR alpha beta+ cells originate from multiple pathways. J Immunol. 1999.04; 162 (7): 3753-3756. ( PubMed )

  4. E Sebzda, S Mariathasan, T Ohteki, R Jones, M F Bachmann, P S Ohashi: Selection of the T cell repertoire. Annu Rev Immunol. 1999.01; 17 829-874. ( PubMed , DOI )

  1. S Mariathasan, M F Bachmann, D Bouchard, T Ohteki, P S Ohashi: Degree of TCR internalization and Ca2+ flux correlates with thymocyte selection. J Immunol. 1998.12; 161 (11): 6030-6037. ( PubMed )

  2. T Ohteki, H Yoshida, T Matsuyama, G S Duncan, T W Mak, P S Ohashi: The transcription factor interferon regulatory factor 1 (IRF-1) is important during the maturation of natural killer 1.1+ T cell receptor-alpha/beta+ (NK1+ T) cells, natural killer cells, and intestinal intraepithelial T cells. J Exp Med. 1998.03; 187 (6): 967-972. ( PubMed )

  3. H Yoshida, H Nishina, H Takimoto, L E Marengère, A C Wakeham, D Bouchard, Y Y Kong, T Ohteki, A Shahinian, M Bachmann, P S Ohashi, J M Penninger, G R Crabtree, T W Mak: The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity. 1998.01; 8 (1): 115-124. ( PubMed )

  1. T Ohteki, S Ho, H Suzuki, T W Mak, P S Ohashi: Role for IL-15/IL-15 receptor beta-chain in natural killer 1.1+ T cell receptor-alpha beta+ cell development. J Immunol. 1997.12; 159 (12): 5931-5935. ( PubMed )

  2. M F Bachmann, T Ohteki, K M Faienza, A Zakarian, D Kägi, D E Speiser, P S Ohashi: Altered peptide ligands trigger perforin- rather than Fas-dependent cell lysis. J Immunol. 1997.11; 159 (9): 4165-4170. ( PubMed )

  3. M Shimamura, T Ohteki, U Beutner, H R MacDonald: Lack of directed V alpha 14-J alpha 281 rearrangements in NK1+ T cells. Eur J Immunol. 1997.06; 27 (6): 1576-1579. ( PubMed , DOI )

  4. M Shimamura, T Ohteki, P Launois, A M Garcia, H R MacDonald: Thymus-independent generation of NK1+ T cells in vitro from fetal liver precursors. J Immunol. 1997.04; 158 (8): 3682-3689. ( PubMed )

  5. U Beutner, P Launois, T Ohteki, J A Louis, H R MacDonald: Natural killer-like T cells develop in SJL mice despite genetically distinct defects in NK1.1 expression and in inducible interleukin-4 production. Eur J Immunol. 1997.04; 27 (4): 928-934. ( PubMed , DOI )

  1. DE Speiser, E Sebzda, T Ohteki, M F Bachmann, K Pfeffer, TW Mak, PS Ohashi: Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo. Eur. J. Immunol.. 1996.12; 26 (12): 3055-3060. ( PubMed , DOI )

  2. T Ohteki, H R MacDonald: Stringent V beta requirement for the development of NK1.1+ T cell receptor-alpha/beta+ cells in mouse liver. J. Exp. Med.. 1996.03; 183 (3): 1277-1282. ( PubMed )

  3. T Ohteki, A Wilson, S Verbeek, H R MacDonald, H Clevers: Selectively impaired development of intestinal T cell receptor gamma delta+ cells and liver CD4+ NK1+ T cell receptor alpha beta+ cells in T cell factor-1-deficient mice. Eur. J. Immunol.. 1996.02; 26 (2): 351-355. ( PubMed , DOI )

  1. P Launois, T Ohteki, K Swihart, H R MacDonald, J A Louis: In susceptible mice, Leishmania major induce very rapid interleukin-4 production by CD4+ T cells which are NK1.1-. Eur. J. Immunol.. 1995.12; 25 (12): 3298-3307. ( PubMed , DOI )

  2. P R Walker, T Ohteki, J A Lopez, H R MacDonald, J L Maryanski: Distinct phenotypes of antigen-selected CD8 T cells emerge at different stages of an in vivo immune response. J. Immunol.. 1995.10; 155 (7): 3443-3452. ( PubMed )

  3. T Ohteki, M Iwamoto, S Izui, H R MacDonald: Reduced development of CD4-8-B220+ T cells but normal autoantibody production in lpr/lpr mice lacking major histocompatibility complex class I molecules. Eur. J. Immunol.. 1995.01; 25 (1): 37-41. ( PubMed , DOI )

  1. T Ohteki, H R MacDonald: Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice. J. Exp. Med.. 1994.08; 180 (2): 699-704. ( PubMed )

  2. J P Rosat, M Schreyer, T Ohteki, G A Waanders, H R MacDonald, J A Louis: Selective expansion of activated V delta 4+ cells during experimental infection of mice with Leishmania major. Eur. J. Immunol.. 1994.02; 24 (2): 496-499. ( PubMed , DOI )

  1. T Ohteki, H R MacDonald: Expression of the CD28 costimulatory molecule on subsets of murine intestinal intraepithelial lymphocytes correlates with lineage and responsiveness. Eur. J. Immunol.. 1993.06; 23 (6): 1251-1255. ( PubMed , DOI )

  2. N Koyamada, T Ohteki, T Abo, T Fukumori, N Ohkouchi, S Satomi, Y Taguchi, A Kusumi, S Mori, K Kumagai: Induction of specific tolerance by hepatic double-negative CD4-8- alpha beta T cells of mice immunized with allogeneic cells via the portal vein in vivo [corrected]. Cell. Immunol.. 1993.06; 149 (1): 107-116. ( PubMed )

  3. T Ohteki, S Okamoto, M Nakamura, E Nemoto, K Kumagai: Elevated production of interleukin 6 by hepatic MNC correlates with ICAM-1 expression on the hepatic sinusoidal endothelial cells in autoimmune MRL/lpr mice. Immunol. Lett.. 1993.05; 36 (2): 145-152. ( PubMed )

  4. T Ohteki, T Abo, A Kusumi, T Sasaki, S Shibata, S Seki, K Kumagai: Age-associated increase of CD5+ B cells in the liver of autoimmune (NZB x NZW) F1 mice. Microbiol. Immunol.. 1993.01; 37 (3): 221-228. ( PubMed )

  1. T Iiai, H Watanabe, S Seki, K Sugiura, K Hirokawa, M Utsuyama, H Takahashi-Iwanaga, T Iwanaga, T Ohteki, T Abo: Ontogeny and development of extrathymic T cells in mouse liver. Immunology. 1992.12; 77 (4): 556-563. ( PubMed )

  2. A Kusumi, T Abo, T Masuda, K Sugiura, S Seki, T Ohteki, R Okuyama, K Kumagai: Lymphotoxin activates hepatic T cells and simultaneously induces profound thymic atrophy. Immunology. 1992.10; 77 (2): 177-184. ( PubMed )

  3. T Ohteki, R Okuyama, S Seki, T Abo, K Sugiura, A Kusumi, T Ohmori, H Watanabe, K Kumagai: Age-dependent increase of extrathymic T cells in the liver and their appearance in the periphery of older mice. J. Immunol.. 1992.09; 149 (5): 1562-1570. ( PubMed )

  4. T Abo, A Kusumi, S Seki, T Ohteki, K Sugiura, T Masuda, H Rikiishi, T Iiai, K Kumagai: Activation of extrathymic T cells in the liver and reciprocal inactivation of intrathymic T cells by bacterial stimulation. Cell. Immunol.. 1992.06; 142 (1): 125-136. ( PubMed )

  5. R Okuyama, T Abo, S Seki, T Ohteki, K Sugiura, A Kusumi, K Kumagai: Estrogen administration activates extrathymic T cell differentiation in the liver. J. Exp. Med.. 1992.03; 175 (3): 661-669. ( PubMed )

  6. H Watanabe, K Ohtsuka, M Kimura, Y Ikarashi, K Ohmori, A Kusumi, T Ohteki, S Seki, T Abo: Details of an isolation method for hepatic lymphocytes in mice. J. Immunol. Methods. 1992.02; 146 (2): 145-154. ( PubMed )

  1. T Masuda, T Ohteki, T Abo, S Seki, S Nose, H Nagura, K Kumagai: Expansion of the population of double negative CD4-8- T alpha beta-cells in the liver is a common feature of autoimmune mice. J. Immunol.. 1991.11; 147 (9): 2907-2912. ( PubMed )

  2. S Seki, T Abo, K Sugiura, T Ohteki, T Kobata, H Yagita, K Okumura, H Rikiishi, T Masuda, K Kumagai: Reciprocal T cell responses in the liver and thymus of mice injected with syngeneic tumor cells. Cell. Immunol.. 1991.10; 137 (1): 46-60. ( PubMed )

  3. T Abo, T Ohteki, S Seki, N Koyamada, Y Yoshikai, T Masuda, H Rikiishi, K Kumagai: The appearance of T cells bearing self-reactive T cell receptor in the livers of mice injected with bacteria. J. Exp. Med.. 1991.08; 174 (2): 417-424. ( PubMed )

  4. S Seki, T Abo, T Ohteki, K Sugiura, K Kumagai: Unusual alpha beta-T cells expanded in autoimmune lpr mice are probably a counterpart of normal T cells in the liver. J. Immunol.. 1991.08; 147 (4): 1214-1221. ( PubMed )

  5. T Ohteki, T Abo, S Seki, T Kobata, H Yagita, K Okumura, K Kumagai: Predominant appearance of gamma/delta T lymphocytes in the liver of mice after birth. Eur. J. Immunol.. 1991.07; 21 (7): 1733-1740. ( PubMed , DOI )

  1. J Satoh, H Seino, S Shintani, S Tanaka, T Ohteki, T Masuda, T Nobunaga, T Toyota: Inhibition of type 1 diabetes in BB rats with recombinant human tumor necrosis factor-alpha. J. Immunol.. 1990.09; 145 (5): 1395-1399. ( PubMed )

  2. S Seki, T Abo, T Masuda, T Ohteki, A Kanno, K Takeda, H Rikiishi, H Nagura, K Kumagai: Identification of activated T cell receptor gamma delta lymphocytes in the liver of tumor-bearing hosts. J. Clin. Invest.. 1990.08; 86 (2): 409-415. ( PubMed , DOI )

  3. T Ohteki, S Seki, T Abo, K Kumagai: Liver is a possible site for the proliferation of abnormal CD3+4-8- double-negative lymphocytes in autoimmune MRL-lpr/lpr mice. J. Exp. Med.. 1990.07; 172 (1): 7-12. ( PubMed )

  4. Toshiaki Ohteki: Analysis of lymphoproliferative disorders in autoimmune model mouse (MRL-lpr/lpr) accompanying Sjögren’s syndrome. Tohoku Univ Dent J. 1990.01; 9 73-82.

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