恒常性医学分野

86  件  
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  1. Akihiro Shimba, Shizue Tani-Ichi, Kyoko Masuda, Guangwei Cui, Satoru Munakata, Shinya Abe, Satsuki Kitano, Hitoshi Miyachi, Hiroshi Kawamoto, Koichi Ikuta: A Chimeric IL-7Rα/IL-2Rβ Receptor Promotes the Differentiation of T Cell Progenitors into B Cells and Type 2 Innate Lymphoid Cells. J Immunol. 2024.10; 213 (7): 952-964. ( PubMed , DOI )

  2. Shizue Tani-Ichi, David Obwegs, Alice Yoshikawa, Hitomi Watanabe, Satsuki Kitano, Aki Ejima, Shinya Hatano, Hitoshi Miyachi, Guangwei Cui, Akihiro Shimba, Shinya Abe, Shohei Hori, Gen Kondoh, Sagar, Yasunobu Yoshikai, Koichi Ikuta: A RORE-dependent Intronic Enhancer in the IL-7 Receptor-α Locus Controls Glucose Metabolism via Vγ4+ γδT17 Cells. J Immunol. 2024.08; 213 (3): 283-295. ( PubMed , DOI )

  3. Riki Ishibashi, Ritsuko Maki, Fumiko Toyoshima: Gene targeting in adult organs using in vivo cleavable donor plasmids for CRISPR-Cas9 and CRISPR-Cas12a Scientific Reports. 2024.03; 14 (1): 7615. ( DOI )

  4. Guangwei Cui, Shinya Abe, Ryoma Kato, Koichi Ikuta: Insights into the heterogeneity of iNKT cells: tissue-resident and circulating subsets shaped by local microenvironmental cues. Front Immunol. 2024; 15 1349184. ( PubMed , DOI )

  5. Koichi Ikuta, Takuma Asahi, Guangwei Cui, Shinya Abe, Daichi Takami: Control of the Development, Distribution, and Function of Innate-Like Lymphocytes and Innate Lymphoid Cells by the Tissue Microenvironment. Adv Exp Med Biol. 2024; 1444 111-127. ( PubMed , DOI )

  1. Satoshi Kozuki, Mio Kabata, Satoko Sakurai, Keiko Iwaisako, Tomomi Nishimura, Masakazu Toi, Takuya Yamamoto, Fumiko Toyoshima: Periportal hepatocyte proliferation at midgestation governs maternal glucose homeostasis in mice Communications Biology. 2023.12; 6 (1): 1226. ( DOI )

  2. Daichi Takami, Shinya Abe, Akihiro Shimba, Takuma Asahi, Guangwei Cui, Shizue Tani-Ichi, Takahiro Hara, Keishi Miyata, Masashi Ikutani, Kiyoshi Takatsu, Yuichi Oike, Koichi Ikuta: Lung group 2 innate lymphoid cells differentially depend on local IL-7 for their distribution, activation, and maintenance in innate and adaptive immunity-mediated airway inflammation. Int Immunol. 2023.11; 35 (11): 513-530. ( PubMed , DOI )

  3. Guangwei Cui, Akihiro Shimba, Jianshi Jin, Nozomi Hojo, Takuma Asahi, Shinya Abe, Aki Ejima, Shinri Okada, Keizo Ohira, Ryoma Kato, Shizue Tani-Ichi, Ryo Yamada, Takashi Ebihara, Katsuyuki Shiroguchi, Koichi Ikuta: CD45 alleviates airway inflammation and lung fibrosis by limiting expansion and activation of ILC2s. Proc Natl Acad Sci U S A. 2023.09; 120 (36): e2215941120. ( PubMed , DOI )

  4. Shinya Abe, Takuma Asahi, Takahiro Hara, Guangwei Cui, Akihiro Shimba, Shizue Tani-Ichi, Kohei Yamada, Kazuko Miyazaki, Hitoshi Miyachi, Satsuki Kitano, Naotoshi Nakamura, Junichi Kikuta, Alexis Vandenbon, Masaki Miyazaki, Ryo Yamada, Toshiaki Ohteki, Masaru Ishii, Veronika Sexl, Takashi Nagasawa, Koichi Ikuta: Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow. Cell Rep. 2023.09; 42 (9): 113127. ( PubMed , DOI )

  5. Takuma Asahi, Shinya Abe, Guangwei Cui, Akihiro Shimba, Tsukasa Nabekura, Hitoshi Miyachi, Satsuki Kitano, Keizo Ohira, Johannes M Dijkstra, Masaki Miyazaki, Akira Shibuya, Hiroshi Ohno, Koichi Ikuta: Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches. Elife. 2023.06; 12 ( PubMed , DOI )

  6. Takuma Asahi, Shinya Abe, Yuya Tajika, Hans-Reimer Rodewald, Veronika Sexl, Hiroshi Takeshima, Koichi Ikuta: Retinoic acid receptor activity is required for the maintenance of type 1 innate lymphoid cells. Int Immunol. 2023.03; 35 (3): 147-155. ( PubMed , DOI )

  1. Ishibashi R, Maki R, Kitano S, Miyachi H, Toyoshima F.: Development of an in vivo cleavable donor plasmid for targeted transgene integration by CRISPR-Cas9 and CRISPR-Cas12a Scientific Reports. 2022.10; 12 (1): ( DOI )

  2. Koichi Ikuta, Aki Ejima, Shinya Abe, Akihiro Shimba: Control of immunity and allergy by steroid hormones. Allergol Int. 2022.10; 71 (4): 432-436. ( PubMed , DOI )

  3. Guangwei Cui, Akihiro Shimba, Jianshi Jin, Taisaku Ogawa, Yukiko Muramoto, Hitoshi Miyachi, Shinya Abe, Takuma Asahi, Shizue Tani-Ichi, Johannes M Dijkstra, Yayoi Iwamoto, Kirill Kryukov, Yuanbo Zhu, Daichi Takami, Takahiro Hara, Satsuki Kitano, Yan Xu, Hajime Morita, Moyu Zhang, Lynn Zreka, Keishi Miyata, Takashi Kanaya, Shinya Okumura, Takashi Ito, Etsuro Hatano, Yoshimasa Takahashi, Hiroshi Watarai, Yuichi Oike, Tadashi Imanishi, Hiroshi Ohno, Toshiaki Ohteki, Nagahiro Minato, Masato Kubo, Georg A Holländer, Hideki Ueno, Takeshi Noda, Katsuyuki Shiroguchi, Koichi Ikuta: A circulating subset of iNKT cells mediates antitumor and antiviral immunity. Sci Immunol. 2022.10; 7 (76): eabj8760. ( PubMed , DOI )

  4. Aki Ejima, Shinya Abe, Akihiro Shimba, Susumu Sato, Takuya Uehata, Shizue Tani-Ichi, Satoru Munakata, Guangwei Cui, Osamu Takeuchi, Toyohiro Hirai, Shigeaki Kato, Koichi Ikuta: Androgens Alleviate Allergic Airway Inflammation by Suppressing Cytokine Production in Th2 Cells. J Immunol. 2022.09; 209 (6): 1083-1094. ( PubMed , DOI )

  5. Ichijo R, Maki K, Kabata M, Murata T, Nagasaka A, Ishihara S, Haga H, Honda T, Adachi T, Yamamoto T, Toyoshima F.: Vasculature atrophy causes a stiffened microenvironment that augments epidermal stem cell differentiation in aged skin Nature Aging. 2022.07; 2 (7): ( DOI )

  6. Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations. 2022.05; 39 (6): 110785. ( PubMed , DOI )

  7. Satoshi Kozuki, Satoko Sakurai, Atsushi Suzuki, Takuya Yamamoto, Fumiko Toyoshima: Delineation of biliary epithelial cell dynamics in maternal liver during pregnancy Genes to Cells. 2022.03; 27 (3): ( DOI )

  1. Yukako Oda, Chisato Takahashi, Shota Harada, Shun Nakamura, Daxiao Sun, Kazumi Kiso, Yuko Urata, Hitoshi Miyachi, Yoshinori Fujiyoshi, Alf Honigmann, Seiichi Uchida, Yasushi Ishihama, Fumiko Toyoshima: Discovery of anti-inflammatory physiological peptides that promote tissue repair by reinforcing epithelial barrier formation. Sci Adv. 2021.11; 7 (47): eabj6895. ( PubMed , DOI )

  2. Chromatin Remodeling of Colorectal Cancer Liver Metastasis is Mediated by an HGF-PU.1-DPP4 Axis. 2021.08; e2004673. ( PubMed , DOI )

  3. Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair. 2021.07; 10 ( PubMed , DOI )

  4. Ryo Ichijo, Mio Kabata, Hiroyasu Kidoya, Fumitaka Muramatsu, Riki Ishibashi, Kota Abe, Ko Tsutsui, Hirokazu Kubo, Yui Iizuka, Satsuki Kitano, Hitoshi Miyachi, Yoshiaki Kubota, Hironobu Fujiwara, Aiko Sada, Takuya Yamamoto, Fumiko Toyoshima: Vasculature-driven stem cell population coordinates tissue scaling in dynamic organs Science Advances. 2021.02; 7 (7): eabd2575. ( PubMed , DOI )

  5. Koichi Ikuta, Takahiro Hara, Shinya Abe, Takuma Asahi, Daichi Takami, Guangwei Cui: The Roles of IL-7 and IL-15 in Niches for Lymphocyte Progenitors and Immune Cells in Lymphoid Organs. Curr Top Microbiol Immunol. 2021; 434 83-101. ( PubMed , DOI )

  1. Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia 2020.12; 203 (10): 1275-1289. ( PubMed , DOI )

  2. Riki Ishibashi, Kota Abe, Nanami Ido, Satsuki Kitano, Hitoshi Miyachi, Fumiko Toyoshima: Genome editing with the donor plasmid equipped with synthetic crRNA-target sequence Scientific Reports. 2020.08; 10 (1): ( DOI )

  3. Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis 2020.07; 22 (8): 934-946. ( PubMed , DOI )

  4. Shizue Tani-Ichi, Keisuke Wagatsuma, Takahiro Hara, Guangwei Cui, Shinya Abe, Hitoshi Miyachi, Satsuki Kitano, Koichi Ikuta: γδ T Cells Require TCR Signaling for Homeostasis in Peripheral Lymphoid Organs. J Immunol. 2020.05; 204 (10): 2671-2684. ( PubMed , DOI )

  5. Yuanbo Zhu, Guangwei Cui, Eiji Miyauchi, Yuki Nakanishi, Hisa Mukohira, Akihiro Shimba, Shinya Abe, Shizue Tani-Ichi, Takahiro Hara, Hiroshi Nakase, Tsutomu Chiba, Atsuko Sehara-Fujisawa, Hiroshi Seno, Hiroshi Ohno, Koichi Ikuta: Intestinal epithelial cell-derived IL-15 determines local maintenance and maturation of intra-epithelial lymphocytes in the intestine. Int Immunol. 2020.05; 32 (5): 307-319. ( PubMed , DOI )

  6. Yolk-sac-derived macrophages progressively expand in the mouse kidney with age 2020.04; 9 ( PubMed , DOI )

  1. Hisa Mukohira, Takahiro Hara, Shinya Abe, Shizue Tani-Ichi, Atsuko Sehara-Fujisawa, Takashi Nagasawa, Kazuyuki Tobe, Koichi Ikuta: Mesenchymal stromal cells in bone marrow express adiponectin and are efficiently targeted by an adiponectin promoter-driven Cre transgene. Int Immunol. 2019.10; 31 (11): 729-742. ( PubMed , DOI )

  2. Katsura H, Kobayashi Y, Tata PR, Hogan BLM: IL-1 and TNFα Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration. Stem Cell Reports. 2019.04; 12 (4): 657-666. ( PubMed , DOI )

  3. Shiho Ueda, Hidemi Hayashi, Takako Miyamoto, Shinya Abe, Kana Hirai, Kanji Matsukura, Hideki Yagi, Yuta Hara, Kinji Yoshida, Shogo Okazaki, Masakazu Tamura, Yuki Abe, Toshinori Agatsuma, Shin-Ichiro Niwa, Kazue Masuko, Takashi Masuko: Anti-tumor effects of mAb against L-type amino acid transporter 1 (LAT1) bound to human and monkey LAT1 with dual avidity modes. Cancer Sci. 2019.02; 110 (2): 674-685. ( PubMed , DOI )

  1. Teruasa Murata, Tetsuya Honda, Gyohei Egawa, Yasuo Yamamoto, Ryo Ichijo, Fumiko Toyoshima, Teruki Dainichi, Kenji Kabashima: Transient elevation of cytoplasmic calcium ion concentration at a single cell level precedes morphological changes of epidermal keratinocytes during cornification Scientific Reports. 2018.04; 8 (1): 6610. ( PubMed , DOI )

  2. Akihiro Shimba, Guangwei Cui, Shizue Tani-Ichi, Makoto Ogawa, Shinya Abe, Fumie Okazaki, Satsuki Kitano, Hitoshi Miyachi, Hisakata Yamada, Takahiro Hara, Yasunobu Yoshikai, Takashi Nagasawa, Günther Schütz, Koichi Ikuta: Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4. Immunity. 2018.02; 48 (2): 286-298.e6. ( PubMed , DOI )

  3. Nishie T, Kobayashi Y, Kimura K, Okuda K: Acute stimulation of a smooth muscle constrictor by oestradiol-17β via GPER1 in bovine oviducts Reproduction in Domestic Animals. 2018; 53 (2): 326-332.

  1. Ryo Ichijo, Hiroki Kobayashi, Saori Yoneda, Yui Iizuka, Hirokazu Kubo, Shigeru Matsumura, Satsuki Kitano, Hitoshi Miyachi, Tetsuya Honda, Fumiko Toyoshima: Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration NATURE COMMUNICATIONS. 2017.09; 8 (1): 508. ( PubMed , DOI )

  2. Adrenomedullin regulates the speed of oviductal fluid flow in cattle 2017.08; 84 (8): 712-718. ( PubMed , DOI )

  3. A G-quadruplex structure at the 5' end of the H19 coding region regulates H19 transcription 2017.04; 7 45815. ( PubMed , DOI )

  4. Local effect of lysophosphatidic acid on prostaglandin production in the bovine oviduct 2017.04; 29 (5): 1021-1028. ( PubMed , DOI )

  5. Essential roles of Tbx3 in embryonic skin development during epidermal stratification 2017.03; 22 (3): 284-292. ( PubMed , DOI )

  6. Dormant Pluripotent Cells Emerge during Neural Differentiation of Embryonic Stem Cells in a FoxO3-Dependent Manner 2017.03; 37 (5): e00417-16. ( PubMed , DOI )

  1. Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1 2016.06; 7 ncomms11858. ( PubMed , DOI )

  2. c-Rel Regulates Inscuteable Gene Expression during Mouse Embryonic Stem Cell Differentiation 2016.02; 291 (7): 3333-3345. ( PubMed , DOI )

  1. PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2 2015.08; 17 (8): 1024-U360. ( PubMed , DOI )

  2. PCTK1 Regulates Integrin-Dependent Spindle Orientation via Protein Kinase A Regulatory Subunit KAP0 and Myosin X 2015.04; 35 (7): 1197-1208. ( PubMed , DOI )

  1. Pregnenolone Functions in Centriole Cohesion during Mitosis 2014.12; 21 (12): 1707-1721. ( PubMed , DOI )

  2. Inhibition of endocytic vesicle fusion by Plk1-mediated phosphorylation of vimentin during mitosis 2014.01; 13 (1): 126-137. ( PubMed , DOI )

  1. ABL1 regulates spindle orientation in adherent cells and mammalian skin 2012.01; 3 626. ( PubMed , DOI )

  2. ABL1 Joins the Cadre of Spindle Orientation Machinery 2012; 37 (2): 81-87. ( PubMed , DOI )

  1. Revolving movement of a dynamic cluster of actin filaments during mitosis 2010.11; 191 (3): 453-462. ( PubMed , DOI )

  1. Dual Role of Cdc42 in Spindle Orientation Control of Adherent Cells 2009.05; 29 (10): 2816-2827. ( PubMed , DOI )

  1. PtdIns(3,4,5)P3 regulates spindle orientation in adherent cells 2007.12; 13 (6): 796-811. ( PubMed , DOI )

  2. Spindle orientation in animal cell mitosis: Roles of integrin in the control of spindle axis 2007.11; 213 (2): 407-411. ( PubMed , DOI )

  3. Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1 2007.05; 282 (20): 15217-15227. ( PubMed , DOI )

  4. Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1-and myosin X-dependent manner 2007.03; 26 (6): 1487-1498. ( PubMed , DOI )

  1. Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate 2003.07; 278 (28): 25277-25280. ( PubMed , DOI )

  1. Nuclear translocation of Plk1 mediated by its bipartite nuclear localization signal 2002.12; 277 (50): 48884-48888. ( PubMed , DOI )

  2. Plk1 promotes nuclear translocation of human Cdc25C during prophase 2002.04; 3 (4): 341-348. ( PubMed , DOI )

  1. Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase 2001.03; 410 (6825): 215-220. ( PubMed , DOI )

  1. Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G(2) checkpoint 1998.05; 17 (10): 2728-2735. ( PubMed , DOI )

  1. A novel SAPK/JNK kinase, MKK7, stimulated by TNF alpha and cellular stresses 1997.12; 16 (23): 7045-7053. ( PubMed , DOI )

  2. Fas induces cytoplasmic apoptotic responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases 1997.11; 139 (4): 1005-1015. ( PubMed , DOI )

  1. Purification and identification of a major activator for p38 from osmotically shocked cells - Activation of mitogen-activated protein kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2 1996.10; 271 (43): 26981-26988. ( PubMed , DOI )

  1. 阿部　真也, 旭　拓真, 生田　宏一: グループ1ILCの分化と機能 実験医学. 2024.08; 42 (12): 1834-1839.

  2. 阿部　真也, 生田　宏一: 骨髄NK細胞は造血系細胞が産生するIL-15に依存して分化する 臨床免疫・アレルギー科. 2024.05; 81 (5): 517-522.

  3. 旭　拓真, 阿部　真也, 生田　宏一: 1型自然リンパ球の多様性と生体内微小環境 医学のあゆみ. 2024.01; 288 (1):

  1. 旭　拓真, 阿部　真也, 生田　宏一: 1型自然リンパ球とNK細胞の多様性 臨床免疫・アレルギー科. 2023.07; 80 (1): 1-7.

  1. Mechanisms for the oriented cell division in mammalian cells 2012; 84 (2): 81-91. ( PubMed )

  1. Toyoshima F: [Inositol phospholipid regulates spindle orientation in adherent cells]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 2008.09; 53 (11): 1345-1350. ( PubMed )

  1. Altered ontogeny and transcriptomic signatures of tissue-resident pulmonary interstitial macrophages ameliorate allergic airway hyperresponsiveness Frontiers in Immunology. 2024.06; 15: 1371764 ( DOI )

  1. Konkimalla A*, Konishi S*, Macadlo L*, Kobayashi Y, Farino ZJ, Miyashita N, Haddad LEI, Morowitz J, Barkauskas CE, Agarwal P, Souma T, ElMallah MK, Tata A, Tata PR. *Contributed equally: Transitional cell states sculpt tissue topology during lung regeneration Cell Stem Cell. 2023.11; 30 (11): 1486-1502.e9. ( DOI )

  1. Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair 2022.11; 41 (6): 111610. ( DOI )

  2. Multi-apical polarity of alveolar stem cells and their dynamics during lung development and regeneration 2022.09; 105114. ( DOI )

  3. Coupled myovascular expansion directs cardiac growth and regeneration 2022.09; 149 (18): ( DOI )

  4. Human distal lung maps and lineage hierarchies reveal a bipotent progenitor 2022.04; 604 (7904): 111-119. ( DOI )

  5. Epigenetic basis of oncogenic-Kras-mediated epithelial-cellular proliferation and plasticity 2022.02; 57 (3): 310-328.e9. ( DOI )

  1. Plate M, Kobayashi Y, Chambers RC, Tata PR: Lung Stem Cells in Development, Health and Disease - Epithelial stem cells at the intersection of tissue regeneration and pulmonary fibrosis European Respiratory Society Publications (ERS Monograph). 2021.04;

  2. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. 2021.03;

  1. A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics 2020.11; 9 ( DOI )

  2. Human lung stem cell-based alveolospheres provide insights into SARS-CoV-2 mediated interferon responses and pneumocyte dysfunction 2020.10; 27 (6): 890-904.e8. ( DOI )

  1. Uezu A, Hisey E, Kobayashi Y, Gao Y, Bradshaw TW, Devlin P, Rodriguiz R, Tata PR, Soderling S: Essential role for InSyn1 in dystroglycan complex integrity and cognitive behaviors in mice. eLife. 2019.12; 8 ( PubMed , DOI )

  1. Tata A, Kobayashi Y, Chow RD, Tran J, Desai A, Massri AJ, McCord TJ, Gunn MD, Tata PR: Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury. Cell Stem Cell. 2018.05; 22 (5): 668-683.e6. ( PubMed , DOI )

  2. Niche-mediated BMP/SMAD signaling regulates lung alveolar stem cell proliferation and differentiation 2018.05; 145 (9): dev163014. ( PubMed , DOI )

  3. Kobayashi Y, Tata PR: Pulmonary Neuroendocrine Cells: Sensors and Sentinels of the Lung. Developmental Cell. 2018.05; 45 (4): 425-426. ( PubMed , DOI )

  1. Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint 1998.05; 17 (10): 2728-2735. ( DOI )

  1. A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses 1997.12; 16 (23): 7045-7053. ( DOI )

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