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92  articles.  
* There may be some overlapped articles listed due to the difference of format.

  1. Yamashita Yasunobu, Itoh Yukihiro, Takada Yuri, Suzuki Takayoshi: アルツハイマー病治療薬としてのエピジェネティック阻害薬(Frontiers in Alzheimer's and Dementia Research　Epigenetic Inhibitors as Alzheimer's Disease Therapeutic Agents) Chemical & Pharmaceutical Bulletin. 2024.07; 72 (7): 630-637. ( ichushi )

  2. Iida Tetsuya, Itoh Yukihiro, Takahashi Yukari, Miyake Yuka, Zamani Farzad, Yamashita Yasunobu, Takada Yuri, Akiyama Toshiki, Ibaraki Jun, Okuda Kyoka, Tokuda Yuto, Nishimura Tomoka, Hidaka Koto, Mori Hiiro, Oba Makoto, Suzuki Takayoshi: リジンデメチラーゼ5に対する蛋白質分解標的キメラ(PROTAC)の同定とその神経突起伸展促進活性(Frontiers in Alzheimer's and Dementia Research　Identification of Proteolysis Targeting Chimeras(PROTACs) for Lysine Demethylase 5 and Their Neurite Outgrowth-Promoting Activity) Chemical & Pharmaceutical Bulletin. 2024.07; 72 (7): 638-647. ( ichushi )

  3. Identification of a novel histone H2A mono-ubiquitination-inhibiting cell-active small molecule. 2024.06; 105 129759. ( PubMed , DOI )

  4. Nurani Atika, Yamashita Yasunobu, Taki Yuuki, Takada Yuri, Itoh Yukihiro, Suzuki Takayoshi: 機械学習を基盤とした薬物スクリーニングを介したヒストン脱アセチル化酵素8阻害剤の同定(Advanced Medicinal Chemistry in Academia　Identification of a Histone Deacetylase 8 Inhibitor through Drug Screenings Based on Machine Learning) Chemical & Pharmaceutical Bulletin. 2024.02; 72 (2): 173-178. ( ichushi )

  5. Design, synthesis, and biological evaluation of phenylcyclopropylamine-entinostat conjugates that selectively target cancer cells. 2024.02; 100 117632. ( PubMed , DOI )

  6. Takada Yuri, Adachi Kyohei, Fujinaga Yuka, Yamashita Yasunobu, Itoh Yukihiro, Suzuki Takayoshi: リジン特異的脱メチル化酵素1阻害剤としてのSNAIL1ペプチドの構造活性相関研究(Advanced Medicinal Chemistry in Academia　A Structure-Activity Relationship Study of SNAIL1 Peptides as Inhibitors of Lysine-Specific Demethylase 1) Chemical & Pharmaceutical Bulletin. 2024.02; 72 (2): 155-160. ( ichushi )

  7. Structural optimization of a lysine demethylase 5 inhibitor for improvement of its cellular activity. 2024.01; 98 117579. ( PubMed , DOI )

  8. Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice. 2024.01; ( PubMed , DOI )

  9. Epigenetic Inhibitors as Alzheimer's Disease Therapeutic Agents. 2024; 72 (7): 630-637. ( PubMed , DOI )

  10. Identification of a Histone Deacetylase 8 Inhibitor through Drug Screenings Based on Machine Learning. 2024; 72 (2): 173-178. ( PubMed , DOI )

  11. A Structure-Activity Relationship Study of SNAIL1 Peptides as Inhibitors of Lysine-Specific Demethylase 1. 2024; 72 (2): 155-160. ( PubMed , DOI )

  1. Origin of the kinetic HDAC2 ‐selectivity of an HDAC inhibitor 2023.04; 44 (18): 1604-1609. ( PubMed , DOI )

  1. Cancer-Cell-Selective Targeting by Arylcyclopropylamine-Vorinostat Conjugates. 2022.10; 13 (10): 1568-1573. ( PubMed , DOI )

  2. Zhe Wei, Hoshina Naomi, Itoh Yukihiro, Tojo Toshifumi, Suzuki Takayoshi, Hase Koji, Takahashi Daisuke: 新規HDAC1選択的阻害薬は炎症性サイトカイン産生阻害により自己免疫性関節炎を軽減する(A Novel HDAC1-Selective Inhibitor Attenuates Autoimmune Arthritis by Inhibiting Inflammatory Cytokine Production) Biological & Pharmaceutical Bulletin. 2022.09; 45 (9): 1364-1372. ( ichushi )

  3. Recent progress on small molecules targeting epigenetic complexes. 2022.04; 67 102130. ( PubMed , DOI )

  4. Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC). 2022.03; 58 (29): 4635-4638. ( PubMed , DOI )

  5. A Novel HDAC1-Selective Inhibitor Attenuates Autoimmune Arthritis by Inhibiting Inflammatory Cytokine Production. 2022; 45 (9): 1364-1372. ( PubMed , DOI )

  1. Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein Using a Fragment-Merging Approach. 2021.11; 64 (21): 15810-15824. ( PubMed , DOI )

  2. Identification of Novel Histone Deacetylase 6-Selective Inhibitors Bearing 3,3,3-Trifluorolactic Amide (TFLAM) Motif as a Zinc Binding Group. 2021.07; 22 (22): 3158-3163. ( PubMed , DOI )

  3. Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5 C Degraders 2021.02; 16 (10): 1609-1618. ( PubMed , DOI )

  1. Yeong KY, Khaw KY, Takahashi Y, Itoh Y, Murugaiyah V, Suzuki T: Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor. Bioorganic chemistry. 2020.01; 94 103403. ( PubMed , DOI )

  2. Itoh Yukihiro: 戦略的化学的アプローチに基づいたリシン修飾酵素のモジュレーターに関する創薬研究(Drug Discovery Researches on Modulators of Lysine-Modifying Enzymes Based on Strategic Chemistry Approaches) Chemical & Pharmaceutical Bulletin. 2020.01; 68 (1): 34-45. ( ichushi )

  3. Drug discovery researches on modulators of lysine-modifying enzymes based on strategic chemistry approaches 2020; 68 (1): 34-45. ( PubMed , DOI )

  4. Metabolic-Pathway-Oriented Screening Targeting S-Adenosyl- l -methionine Reveals the Epigenetic Remodeling Activities of Naturally Occurring Catechols 2020; 142 (1): 21-26. ( PubMed , DOI )

  1. Itoh Y, Nakashima Y, Tsukamoto S, Kurohara T, Suzuki M, Sakae Y, Oda M, Okamoto Y, Suzuki T: N+-C-H···O Hydrogen bonds in protein-ligand complexes. Scientific reports. 2019.12; 9 (1): 767. ( PubMed , DOI )

  2. Mellini P, Itoh Y, Elboray EE, Tsumoto H, Li Y, Suzuki M, Takahashi Y, Tojo T, Kurohara T, Miyake Y, Miura Y, Kitao Y, Kotoku M, Iida T, Suzuki T: Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NAD+-Binding Site. Journal of medicinal chemistry. 2019.06; 62 (12): 5844-5862. ( PubMed , DOI )

  3. Jaikhan P, Buranrat B, Itoh Y, Chotitumnavee J, Kurohara T, Suzuki T: Identification of ortho-hydroxy anilide as a novel scaffold for lysine demethylase 5 inhibitors. Bioorganic & medicinal chemistry letters. 2019.05; 29 (10): 1173-1176. ( PubMed , DOI )

  4. Ota Yosuke, Nakamura Arisa, Elboray Elghareeb E., Itoh Yukihiro, Suzuki Takayoshi: 創薬　近年の進歩と将来　5-フルオロウラシルとLSD1阻害薬の複合体のデザイン、合成および生物学的評価(Drug Discovery: Recent Progress and the Future: Design, Synthesis, and Biological Evaluation of a Conjugate of 5-Fluorouracil and an LSD1 Inhibitor) Chemical & Pharmaceutical Bulletin. 2019.03; 67 (3): 192-195. ( ichushi )

  5. Miyake Y, Itoh Y, Hatanaka A, Suzuma Y, Suzuki M, Kodama H, Arai Y, Suzuki T: Identification of novel lysine demethylase 5-selective inhibitors by inhibitor-based fragment merging strategy. Bioorganic & medicinal chemistry. 2019.03; 27 (6): 1119-1129. ( PubMed , DOI )

  6. Ota Y, Nakamura A, Elboray EE, Itoh Y, Suzuki T: Design, Synthesis, and Biological Evaluation of a Conjugate of 5-Fluorouracil and an LSD1 Inhibitor. Chemical & pharmaceutical bulletin. 2019; 67 (3): 192-195. ( PubMed , DOI )

  1. Itoh Y: Chemical Protein Degradation Approach and its Application to Epigenetic Targets. Chemical record (New York, N.Y.). 2018.12; 18 (12): 1681-1700. ( PubMed , DOI )

  2. Itoh Y, Suzuki M: Design, synthesis, and biological evaluation of novel ubiquitin-activating enzyme inhibitors. Bioorganic & medicinal chemistry letters. 2018.09; 28 (16): 2723-2727. ( PubMed , DOI )

  3. Tsukamoto S, Sakae Y, Itoh Y, Suzuki T, Okamoto Y: Computational analysis for selectivity of histone deacetylase inhibitor by replica-exchange umbrella sampling molecular dynamics simulations. The Journal of chemical physics. 2018.03; 148 (12): 125102. ( PubMed , DOI )

  4. Ota Y, Miyamura S, Araki M, Itoh Y, Yasuda S, Masuda M, Taniguchi T, Sowa Y, Sakai T, Itami K, Yamaguchi J, Suzuki T: Design, synthesis and evaluation of γ-turn mimetics as LSD1-selective inhibitors. Bioorganic & medicinal chemistry. 2018.02; 26 (3): 775-785. ( PubMed , DOI )

  5. Kakizawa T, Ota Y, Itoh Y, Suzuki T: Histone H3 peptides incorporating modified lysine residues as lysine-specific demethylase 1 inhibitors. Bioorganic & medicinal chemistry letters. 2018.01; 28 (2): 167-169. ( PubMed , DOI )

  6. Ota Y, Kakizawa T, Itoh Y, Suzuki T: Design, Synthesis, and In Vitro Evaluation of Novel Histone H3 Peptide-Based LSD1 Inactivators Incorporating α,α-Disubstituted Amino Acids with γ-Turn-Inducing Structures. Molecules (Basel, Switzerland). 2018; 23 (5): ( PubMed , DOI )

  1. Yukihiro Itoh, Keisuke Aihara, Paolo Mellini, Toshifumi Tojo, Yosuke Ota, Hiroki Tsumoto, Viswas Raja Solomon, Peng Zhan, Miki Suzuki, Daisuke Ogasawara, Akira Shigenaga, Tsubasa Inokuma, Hidehiko Nakagawa, Naoki Miyata, Tamio Mizukami, Akira Otaka, Takayoshi Suzuki: Design, synthesis and biological evaluation of SNAIL1 peptide-based lysine specific demethylase 1 inhibitors Peptide Science 2016. 2017.02; 165-166.

  1. Study of Ligand Binding Selectivity of Histone Deacetylases by Replica-Exchange Umbrella Sampling Molecular Dynamics Simulations 2016.02; 110 (3): 544A-545A.

  1. MEDI 150-Design and synthesis of histone deacetylase 6 selective inhibitors 2006.09; 232

  2. Suzuki Takayoshi, Kouketsu Akiyasu, Itoh Yukihiro, Hisakawa Shinya, Nakagawa Hidehiko, Miyata Naoki: P-440 DISCOVERY OF NOVEL HISTONE DEACETYLASE 6 SELECTIVE INHIBITORS International Symposium on the Chemistry of Natural Products. 2006.07; 2006 "P-440". ( DOI )

  1. Yamashita Yasunobu, Takada Yuri, Itoh Yukihiro, Suzuki Takayoshi: Discovery of HDAC8-selective inhibitors and their application to PROTACs MEDCHEM NEWS. 2023.11; 33 (4): 181-186. ( DOI )

  1. Toru Komatsu, Yukihiro Itoh: Challenges of young chemists to be global Yakugaku Zasshi. 2019; 139 (2): 185-186. ( PubMed , DOI )

  1. Tsukamoto S., Sakae Y., Itoh Y., Suzuki T., Okamoto Y.: 22aPS-113 Study on the selectivity of the epigenetic enzyme inhibitor by generalized-ensemble molecular dynamics simulations Meeting Abstracts of the Physical Society of Japan. 2016; 71 3323. ( DOI )

  1. HDAC6-selective inhibitors 2008.01; 224 (1): 71-74.

  1. Anirban Mukherjee, Yasunobu Yamashita, Ryo Maeda, Toshiki Akiyama, Katsunori Endo, Yuri Takada, Hiroki Tsumoto, Yukiko Moriyama, Akihiro Ito, Fumiyuki Shirai, Makoto Tachibana, Yukihiro Itoh, Takayoshi Suzuki: A Novel PROTAC G9a/GLP Degrader that Inhibits, Similar to G9a siRNA, the Migration of MCF-7 Breast-Cancer Cells without Affecting Proliferation Journal of Medicinal Chemistry. 2025.09; 68 (17): 18258-18271. ( PubMed , DOI )

  2. Yasunobu Yamashita, Yuuki Taki, Yoshinori Wakabayashi, Junichiro Kanazawa, Paddy R. A. Melsen, Yuri Takada, Yukihiro Itoh, Masanobu Uchiyama, Takayoshi Suzuki: A Deep-Learning-Aided Drug Screening Based on Visualization of a Hidden Layer as Chemical Space ACS Medicinal Chemistry Letters. 2025.06; ( DOI )

  1. Tetsuya Iida, Yukihiro Itoh, Yukari Takahashi, Yuka Miyake, Farzad Zamani, Yasunobu Yamashita, Yuri Takada, Toshiki Akiyama, Jun Ibaraki, Kyoka Okuda, Yuto Tokuda, Tomoka Nishimura, Koto Hidaka, Hiiro Mori, Makoto Oba, Takayoshi Suzuki: Identification of Proteolysis Targeting Chimeras (PROTACs) for Lysine Demethylase 5 and Their Neurite Outgrowth-Promoting Activity Chemical and Pharmaceutical Bulletin. 2024.07; 72 (7): 638-647. ( DOI )

  2. 伊藤幸裕, 高田悠里, 山下泰信, 鈴木孝禎: Drug modalities for inhibition of protein-protein interactions 実験医学. 2024; 42 (2):

  1. Yukihiro Itoh, Peng Zhan, Toshifumi Tojo, Pattaporn Jaikhan, Yosuke Ota, Miki Suzuki, Ying Li, Zi Hui, Yukiko Moriyama, Yuri Takada, Yasunobu Yamashita, Makoto Oba, Shusaku Uchida, Mitsuharu Masuda, Shinji Ito, Yoshihiro Sowa, Toshiyuki Sakai, Takayoshi Suzuki: Discovery of Selective Histone Deacetylase 1 and 2 Inhibitors: Screening of a Focused Library Constructed by Click Chemistry, Kinetic Binding Analysis, and Biological Evaluation Journal of Medicinal Chemistry. 2023.10; 66 (22): 15171-15188. ( PubMed , DOI )

  1. Yuri Takada, Yasunobu Yamashita, Yukihiro Itoh, Takayoshi Suzuki: Medicinal Chemistry Research on Targeting Epigenetic Complexes Journal of Synthetic Organic Chemistry, Japan. 2022.07; 80 (7): 664-675. ( DOI )

  1. Yukihiro Itoh, Takashi Kurohara, Takayoshi Suzuki: N+-C-H…O Hydrogen Bonds in Protein-Ligand Complexes and their Application to Drug Design Journal of Synthetic Organic Chemistry, Japan. 2020.12; 78 (12): 1151-1162. ( DOI )

  2. Yuka Miyake, Yukihiro Itoh, Yoshinori Suzuma, Hidehiko Kodama, Takashi Kurohara, Yasunobu Yamashita, Remy Narozny, Yutaro Hanatani, Shusaku Uchida, Takayoshi Suzuki: Metalloprotein-Catalyzed Click Reaction for In Situ Generation of a Potent Inhibitor ACS Catalysis. 2020.04; 10 (10): 5383-5392. ( DOI )

  1. Keiichiro Okuhira, Takuji Shoda, Risa Omura, Nobumichi Ohoka, Takayuki Hattori, Norihito Shibata, Yosuke Demizu, Ryo Sugihara, Asato Ichino, Haruka Kawahara, Yukihiro Itoh, Minoru Ishikawa, Yuichi Hashimoto, Masaaki Kurihara, Susumu Itoh, Hiroyuki Saito, Mikihiko Naito: Targeted degradation of proteins localized in subcellular compartments by hybrid small molecules Molecular Pharmacology. 2017.03; 91 (3): 159-166. ( PubMed , DOI )

  2. Paolo Mellini, Yukihiro Itoh, Hiroki Tsumoto, Ying Li, Miki Suzuki, Natsuko Tokuda, Taeko Kakizawa, Yuri Miura, Jun Takeuchi, Maija Lahtela-Kakkonen, Takayoshi Suzuki: Potent mechanism-based sirtuin-2-selective inhibition by an: In situ -generated occupant of the substrate-binding site, "selectivity pocket" and NAD+-binding site Chemical Science. 2017; 8 (9): 6400-6408. ( PubMed , DOI )

  3. Yukihiro Itoh, Takayoshi Suzuki: “Drug" discovery with the help of organic chemistry Yakugaku Zasshi. 2017; 137 (3): 283-292. ( PubMed , DOI )

  4. Youhei Sohma, Yukihiro Itoh: Chemical biology for pharmaceutical sciences (novel ideas for “drug" discovery) Yakugaku Zasshi. 2017; 137 (3): 281-282. ( PubMed , DOI )

  1. Fumihiro Higuchi, Shusaku Uchida, Hirotaka Yamagata, Naoko Abe-Higuchi, Teruyuki Hobara, Kumiko Hara, Ayumi Kobayashi, Tatsushi Shintaku, Yukihiro Itoh, Takayoshi Suzuki, Yoshifumi Watanabe: Hippocampal microRNA-124 enhances chronic stress resilience in mice Journal of Neuroscience. 2016.07; 36 (27): 7253-7267. ( PubMed , DOI )

  2. Taeko Kakizawa, Tamio Mizukami, Yukihiro Itoh, Makoto Hasegawa, Ryuzo Sasaki, Takayoshi Suzuki: Evaluation of phenylcyclopropylamine compounds by enzymatic assay of lysine-specific demethylase 2 in the presence of NPAC peptide Bioorganic and Medicinal Chemistry Letters. 2016.02; 26 (4): 1193-1195. ( PubMed , DOI )

  3. Yukihiro Itoh, Keisuke Aihara, Paolo Mellini, Toshifumi Tojo, Yosuke Ota, Hiroki Tsumoto, Viswas Raja Solomon, Peng Zhan, Miki Suzuki, Daisuke Ogasawara, Akira Shigenaga, Tsubasa Inokuma, Hidehiko Nakagawa, Naoki Miyata, Tamio Mizukami, Akira Otaka, Takayoshi Suzuki: Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators Journal of Medicinal Chemistry. 2016.02; 59 (4): 1531-1544. ( PubMed , DOI )

  4. Yukihiro Itoh, Miki Suzuki, Taiji Matsui, Yosuke Ota, Zi Hui, Kazunori Tsubaki, Takayoshi Suzuki: False HDAC inhibition by aurone compound Chemical and Pharmaceutical Bulletin. 2016; 64 (8): 1124-1128. ( PubMed , DOI )

  5. Shin Miyamura, Misaho Araki, Yosuke Ota, Yukihiro Itoh, Shusuke Yasuda, Mitsuharu Masuda, Tomoyuki Taniguchi, Yoshihiro Sowa, Toshiyuki Sakai, Takayoshi Suzuki, Kenichiro Itami, Junichiro Yamaguchi: C-H activation enables a rapid structure-activity relationship study of arylcyclopropyl amines for potent and selective LSD1 inhibitors Organic and Biomolecular Chemistry. 2016; 14 (36): 8576-8585. ( PubMed , DOI )

  6. Yosuke Ota, Yukihiro Itoh, Asako Kaise, Kiminori Ohta, Yasuyuki Endo, Mitsuharu Masuda, Yoshihiro Sowa, Toshiyuki Sakai, Takayoshi Suzuki: Targeting Cancer with PCPA-Drug Conjugates: LSD1 Inhibition-Triggered Release of 4-Hydroxytamoxifen Angewandte Chemie - International Edition. 2016; 55 (52): 16115-16118. ( PubMed , DOI )

  7. Yukihiro Itoh, Takayoshi Suzuki: Molecular technology for controlling epigenetics: Regulation of histone acetylation and methylation by small molecules Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 2016; 74 (5): 441-452. ( DOI )

  1. Yukihiro Itoh, Hideyuki Sawada, Miki Suzuki, Toshifumi Tojo, Ryuzo Sasaki, Makoto Hasegawa, Tamio Mizukami, Takayoshi Suzuki: Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells ACS Medicinal Chemistry Letters. 2015.06; 6 (6): 665-670. ( PubMed , DOI )

  2. Taeko Kakizawa, Yosuke Ota, Yukihiro Itoh, Hiroki Tsumoto, Takayoshi Suzuki: Histone H3 peptide based LSD1-selective inhibitors Bioorganic and Medicinal Chemistry Letters. 2015.05; 25 (9): 1925-1928. ( PubMed , DOI )

  3. Mohammed Naseer Ahmed Khan, Hiroki Tsumoto, Yukihiro Itoh, Yosuke Ota, Miki Suzuki, Daisuke Ogasawara, Hidehiko Nakagawa, Tamio Mizukami, Naoki Miyata, Takayoshi Suzuki: Design, synthesis, and biological activity of N-alkylated analogue of NCL1, a selective inhibitor of lysine-specific demethylase 1 MedChemComm. 2015.03; 6 (3): 407-412. ( DOI )

  1. Peng Zhan, Yu'Ning Song, Yukihiro Itoh, Takayoshi Suzuki, Xinyong Liu: Recent advances in the structure-based rational design of TNKSIs Molecular BioSystems. 2014.11; 10 (11): 2783-2799. ( PubMed , DOI )

  2. Hiromi Sekizawa, Kazuma Amaike, Yukihiro Itoh, Takayoshi Suzuki, Kenichiro Itami, Junichiro Yamaguchi: Late-stage C-H coupling enables rapid identification of HDAC inhibitors: Synthesis and evaluation of NCH-31 analogues ACS Medicinal Chemistry Letters. 2014.05; 5 (5): 582-586. ( PubMed , DOI )

  3. Prima R. Tatum, Hideyuki Sawada, Yosuke Ota, Yukihiro Itoh, Peng Zhan, Naoya Ieda, Hidehiko Nakagawa, Naoki Miyata, Takayoshi Suzuki: Identification of novel SIRT2-selective inhibitors using a click chemistry approach Bioorganic and Medicinal Chemistry Letters. 2014.04; 24 (8): 1871-1874. ( PubMed , DOI )

  4. Takayoshi Suzuki, Nobusuke Muto, Masashige Bando, Yukihiro Itoh, Ayako Masaki, Masaki Ri, Yosuke Ota, Hidehiko Nakagawa, Shinsuke Iida, Katsuhiko Shirahige, Naoki Miyata: Design, synthesis, and biological activity of NCC149 derivatives as histone deacetylasea 8-selective inhibitors ChemMedChem. 2014.03; 9 (3): 657-664. ( PubMed , DOI )

  5. Yukihiro Itoh, Naoki Miyata, Takayoshi Suzuki: Target-guided synthesis: Medicinal chemistry strategy to allow target enzymes themselves to synthesize their own inhibitors Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 2014; 72 (6): 702-716. ( DOI )

  6. Yukihiro Itoh, Daisuke Ogasawara, Yosuke Ota, Tamio Mizukami, Takayoshi Suzuki: Synthesis, LSD1 inhibitory activity, and LSD1 Binding model of optically pure lysine-PCPA conjugates Computational and Structural Biotechnology Journal. 2014; 9 (14): e201402002. ( PubMed , DOI )

  1. Yuji Matsuya, Yuta Kobayashi, Sayumi Uchida, Yukihiro Itoh, Hideyuki Sawada, Takayoshi Suzuki, Naoki Miyata, Kenji Sugimoto, Naoki Toyooka: Search for a novel SIRT1 activator: Structural modification of SRT1720 and biological evaluation Bioorganic and Medicinal Chemistry Letters. 2013.09; 23 (17): 4907-4910. ( PubMed , DOI )

  2. Takayoshi Suzuki, Hiroki Ozasa, Yukihiro Itoh, Peng Zhan, Hideyuki Sawada, Koshiki Mino, Louise Walport, Rei Ohkubo, Akane Kawamura, Masato Yonezawa, Yuichi Tsukada, Anthony Tumber, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, Christopher J. Schofield, Naoki Miyata: Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity Journal of Medicinal Chemistry. 2013.09; 56 (18): 7222-7231. ( PubMed , DOI )

  3. Daisuke Ogasawara, Yukihiro Itoh, Hiroki Tsumoto, Taeko Kakizawa, Koshiki Mino, Kiyoshi Fukuhara, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, Naoki Miyata, Takayoshi Suzuki: Lysine-specific demethylase 1-selective inactivators: Protein-targeted drug delivery mechanism Angewandte Chemie - International Edition. 2013.08; 52 (33): 8620-8624. ( PubMed , DOI )

  4. Takayoshi Suzuki, Yuki Kasuya, Yukihiro Itoh, Yosuke Ota, Peng Zhan, Kaori Asamitsu, Hidehiko Nakagawa, Takashi Okamoto, Naoki Miyata: Identification of Highly Selective and Potent Histone Deacetylase 3 Inhibitors Using Click Chemistry-Based Combinatorial Fragment Assembly PLoS ONE. 2013.07; 8 (7): e68669. ( PubMed , DOI )

  5. Yukihiro Itoh, Takayoshi Suzuki, Naoki Miyata: Small-molecular modulators of cancer-associated epigenetic mechanisms Molecular BioSystems. 2013.05; 9 (5): 873-896. ( PubMed , DOI )

  1. Takayoshi Suzuki, Yosuke Ota, Masaki Ri, Masashige Bando, Aogu Gotoh, Yukihiro Itoh, Hiroki Tsumoto, Prima R. Tatum, Tamio Mizukami, Hidehiko Nakagawa, Shinsuke Iida, Ryuzo Ueda, Katsuhiko Shirahige, Naoki Miyata: Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries Journal of Medicinal Chemistry. 2012.11; 55 (22): 9562-9575. ( PubMed , DOI )

  2. Yukihiro Itoh, Minoru Ishikawa, Risa Kitaguchi, Keiichiro Okuhira, Mikihiko Naito, Yuichi Hashimoto: Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist Bioorganic and Medicinal Chemistry Letters. 2012.07; 22 (13): 4453-4457. ( PubMed , DOI )

  3. Takayoshi Suzuki, Mohammed Naseer Ahmed Khan, Hideyuki Sawada, Erika Imai, Yukihiro Itoh, Katsura Yamatsuta, Natsuko Tokuda, Jun Takeuchi, Takuya Seko, Hidehiko Nakagawa, Naoki Miyata: Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors Journal of Medicinal Chemistry. 2012.06; 55 (12): 5760-5773. ( PubMed , DOI )

  1. Yukihiro Itoh, Risa Kitaguchi, Minoru Ishikawa, Mikihiko Naito, Yuichi Hashimoto: Design, synthesis and biological evaluation of nuclear receptor-degradation inducers Bioorganic and Medicinal Chemistry. 2011.11; 19 (22): 6768-6778. ( PubMed , DOI )

  2. Yukihiro Itoh, Minoru Ishikawa, Risa Kitaguchi, Shinichi Sato, Mikihiko Naito, Yuichi Hashimoto: Development of target protein-selective degradation inducer for protein knockdown Bioorganic and Medicinal Chemistry. 2011.05; 19 (10): 3229-3241. ( PubMed , DOI )

  3. Keiichiro Okuhira, Nobumichi Ohoka, Kimie Sai, Tomoko Nishimaki-Mogami, Yukihiro Itoh, Minoru Ishikawa, Yuichi Hashimoto, Mikihiko Naito: Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein FEBS Letters. 2011.04; 585 (8): 1147-1152. ( PubMed , DOI )

  1. Shohei Hamada, Takayoshi Suzuki, Koshiki Mino, Koichi Koseki, Felix Oehme, Ingo Flamme, Hiroki Ozasa, Yukihiro Itoh, Daisuke Ogasawara, Haruka Komaarashi, Aiko Kato, Hiroki Tsumoto, Hidehiko Nakagawa, Makoto Hasegawa, Ryuzo Sasaki, Tamio Mizukami, Naoki Miyata: Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors Journal of Medicinal Chemistry. 2010.08; 53 (15): 5629-5638. ( PubMed , DOI )

  2. Yukihiro Itoh, Minoru Ishikawa, Mikihiko Naito, Yuichi Hashimoto: Protein knockdown using methyl bestatin-ligand hybrid molecules: Design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins Journal of the American Chemical Society. 2010.04; 132 (16): 5820-5826. ( PubMed , DOI )

  1. Shohei Hamada, Tae Dong Kim, Takayoshi Suzuki, Yukihiro Itoh, Hiroki Tsumoto, Hidehiko Nakagawa, Ralf Janknecht, Naoki Miyata: Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors Bioorganic and Medicinal Chemistry Letters. 2009.05; 19 (10): 2852-2855. ( PubMed , DOI )

  1. Takayoshi Suzuki, Sou Ichi Igari, Akira Hirasawa, Mie Hata, Masaji Ishiguro, Hiroki Fujieda, Yukihiro Itoh, Tatsuya Hirano, Hidehiko Nakagawa, Michitaka Ogura, Makoto Makishima, Gozoh Tsujimoto, Naoki Miyata: Identification of G protein-coupled receptor 120-selective agonists derived from PPARγ agonists Journal of Medicinal Chemistry. 2008.12; 51 (23): 7640-7644. ( PubMed , DOI )

  2. Yukihiro Itoh, Takayoshi Suzuki, Naoki Miyata: Isoform-selective histone deacetylase inhibitors Current Pharmaceutical Design. 2008.02; 14 (6): 529-544. ( PubMed , DOI )

  1. Yukihiro Itoh, Takayoshi Suzuki, Akiyasu Kouketsu, Nobuaki Suzuki, Satoko Maeda, Minoru Yoshida, Hidehiko Nakagawa, Naoki Miyata: Design, synthesis, structure-selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors Journal of Medicinal Chemistry. 2007.11; 50 (22): 5425-5438. ( PubMed , DOI )

  2. Takayoshi Suzuki, Shinya Hisakawa, Yukihiro Itoh, Nobuaki Suzuki, Katsumasa Takahashi, Masatoshi Kawahata, Kentaro Yamaguchi, Hidehiko Nakagawa, Naoki Miyata: Design, synthesis, and biological activity of folate receptor-targeted prodrugs of thiolate histone deacetylase inhibitors Bioorganic and Medicinal Chemistry Letters. 2007.08; 17 (15): 4208-4212. ( PubMed , DOI )

  3. Takayoshi Suzuki, Shinya Hisakawa, Yukihiro Itoh, Sakiko Maruyama, Mineko Kurotaki, Hidehiko Nakagawa, Naoki Miyata: Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor Bioorganic and Medicinal Chemistry Letters. 2007.03; 17 (6): 1558-1561. ( PubMed , DOI )

  1. Takayoshi Suzuki, Akiyasu Kouketsu, Yukihiro Itoh, Shinya Hisakawa, Satoko Maeda, Minoru Yoshida, Hidehiko Nakagawa, Naoki Miyata: Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate Journal of Medicinal Chemistry. 2006.08; 49 (16): 4809-4812. ( PubMed , DOI )

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