Integrative Molecular Biomedicine

56  articles.  
* There may be some overlapped articles listed due to the difference of format.

  1. Obata Y, Natsume M, Shiina I, Takahashi T, Nishida T.: Golgi retention of KIT in gastrointestinal stromal tumour cells is phospholipase D activity-dependent bioRxiv. 2025.03;

  2. Electrically Driven, Bioluminescent Compliant Devices for Soft Robotics. ACS Appl Mater Interfaces. 2025.02;

  3. Akimi Yonezawa, Kana Shimomura, Koji Okamoto & Haruna Takeda: Inhibition of BRD4 attenuated IFNγ-induced apoptosis in colorectal cancer organoids. BMC Cancer. 2025.01; ( DOI )

  1. Disruption of cotranscriptional splicing suggests that RBM39 is a therapeutic target in acute lymphoblastic leukemia. Blood. 2024.12;

  2. Mechanistic insights into lethal hyper progressive disease induced by PD-L1 inhibitor in metastatic urothelial carcinoma. NPJ Precis Oncol. 2024.09;

  3. Knockdown of CDX2 Induces microRNA-221 Up-regulation in Human Colon Cancer Cells. Anticancer Res. 2024.08;

  4. Ishitani, R; Takemoto, M; Tomii, K: Protein ligand binding site prediction using graph transformer neural network PLOS ONE. 2024.08; 19 (8): e0308425. ( PubMed , DOI )

  5. Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization. Nat Commun. 2024.08;

  6. Iyoda S, Yoshida K, Shoji K, Ito N, Tanaka M, Nannya Y, Yamato G, Tsujimoto S, Shiba N, Hayashi Y, Shiozawa Y, Shiraishi Y, Chiba K, Okada A, Tanaka H, Miyano S, Koga Y, Goto H, Moritake H, Terui K, Ito E, Kiyokawa N, Tomizawa D, Taga T, Tawa A, Takita J, Nishikori M, Adachi S, Ogawa S, Matsuo H: KRAS G12 mutations as adverse prognostic factors in KMT2A-rearranged acute myeloid leukemia. Leukemia. 2024.07; 38 (7): 1609-1612. ( PubMed , DOI )

  7. Natsume M, Niwa M, Ichikawa S, Okamoto T, Tsutsui H, Usukura D, Murata T, Abe R, Shimonaka M, Nishida T, Shiina I & Obata Y: Brefeldin A and M-COPA block the export of RTKs from the endoplasmic reticulum via simultaneous inactivation of ARF1, ARF4, and ARF5 J. Biol. Chem.. 2024.06; 300 (6): 107327.

  8. Sato T, Yoshida K, Toki T, Kanezaki R, Terui K, Saiki R, Ojima M, Ochi Y, Mizuno S, Yoshihara M, Uechi T, Kenmochi N, Tanaka S, Matsubayashi J, Kisai K, Kudo K, Yuzawa K, Takahashi Y, Tanaka T, Yamamoto Y, Kobayashi A, Kamio T, Sasaki S, Shiraishi Y, Chiba K, Tanaka H, Muramatsu H, Hama A, Hasegawa D, Sato A, Koh K, Karakawa S, Kobayashi M, Hara J, Taneyama Y, Imai C, Hasegawa D, Fujita N, Yoshitomi M, Iwamoto S, Yamato G, Saida S, Kiyokawa N, Deguchi T, Ito M, Matsuo H, Adachi S, Hayashi Y, Taga T, Saito AM, Horibe K, Watanabe K, Tomizawa D, Miyano S, Takahashi S, Ogawa S, Ito E: Landscape of driver mutations and their clinical effects on Down syndrome-related myeloid neoplasms. Blood. 2024.06; 143 (25): 2627-2643. ( PubMed , DOI )

  9. Metabolic reprogramming regulated by TRAF6 contributes to the leukemia progression. Leukemia. 2024.04;

  10. Naoko Iida, Yukari Muranaka, Jun Won Park, Shigeki Sekine, Neal G. Copeland, Nancy A. Jenkins, Yuichi Shiraishi, Masanobu Oshima, Haruna Takeda: Sleeping Beauty transposon mutagenesis in mouse intestinal organoids identifies genes involved in tumor progression and metastasis Cancer Gene Therapy . 2024.01; ( DOI )

  11. Noerenberg, D., Briest, F., Hennch, C., Yoshida, K., Hablesreiter, R., Takeuchi, Y., Ueno, H., Staiger, A. M., Ziepert, M., Asmar, F., Locher, B. N., Toth, E., Weber, T., Amini, R. M., Klapper, W., Bouzani, M., Poeschel, V., Rosenwald, A., Held, G., Campo, E., Ishaque, N., Stamatopoulos, K., Kanellis, G., Anagnostopoulos, I., Bullinger, L., Goldschmidt, N., Zinzani, P. L., Bodor, C., Rosenquist, R., Vassilakopoulos, T. P., Ott, G., Ogawa, S., Damm, F.: Genetic Characterization of Primary Mediastinal B-Cell Lymphoma: Pathogenesis and Patient Outcomes. J Clin Oncol. 2024; 42 (4): 452-466. ( PubMed , DOI )

  12. Aoki, T., Shiba, N., Tsujimoto, S., Yamato, G., Hara, Y., Kato, S., Yoshida, K., Ogawa, S., Hayashi, Y., Iwamoto, S., Taki, T., Shimada, A., Iijima-Yamashita, Y., Horibe, K., Tawa, A., Taga, T., Adachi, S., Tomizawa, D.: High IL2RA/CD25 expression is a prognostic stem cell biomarker for pediatric acute myeloid leukemia without a core-binding factor. Pediatr Blood Cancer. 2024; 71 (2): e30803. ( PubMed , DOI )

  1. Molecular Design Method Using a Reversible Tree Representation of Chemical Compounds and Deep Reinforcement Learning. 2022.09; 62 (17): 4032-4048. ( PubMed , DOI )

  2. Towards universal neural network potential for material discovery applicable to arbitrary combination of 45 elements. 2022.05; 13 (1): 2991. ( PubMed , DOI )

  3. Lateral access mechanism of LPA receptor probed by molecular dynamics simulation. 2022; 17 (2): e0263296. ( PubMed , DOI )

  1. Time-resolved serial femtosecond crystallography reveals early structural changes in channelrhodopsin. 2021.03; 10 ( PubMed , DOI )

  1. Structural biology of the multidrug and toxic compound extrusion superfamily transporters. 2020.12; 1862 (12): 183154. ( PubMed , DOI )

  2. Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation. 2020.05; 3 (1): 240. ( PubMed , DOI )

  3. Identification of Potent In Vivo Autotaxin Inhibitors that Bind to Both Hydrophobic Pockets and Channels in the Catalytic Domain. 2020.03; 63 (6): 3188-3204. ( PubMed , DOI )

  4. Author Correction: Structural basis for the drug extrusion mechanism by a MATE multidrug transporter. 2020.02; 578 (7794): E19. ( PubMed , DOI )

  5. Crystal structure of Drosophila Piwi. 2020.02; 11 (1): 858. ( PubMed , DOI )

  1. Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc. 2019.06; 26 (6): 510-517. ( PubMed , DOI )

  2. Structural basis for oligomerization of the prokaryotic peptide transporter PepTSo2. 2019.05; 75 (Pt 5): 348-358. ( PubMed , DOI )

  3. Structural basis for the promiscuous PAM recognition by Corynebacterium diphtheriae Cas9. 2019.04; 10 (1): 1968. ( PubMed , DOI )

  4. Crystal structure of plant vacuolar iron transporter VIT1. 2019.03; 5 (3): 308-315. ( PubMed , DOI )

  5. Structural Basis of H+-Dependent Conformational Change in a Bacterial MATE Transporter. 2019.02; 27 (2): 293-301. ( PubMed , DOI )

  6. Cap-specific terminal N 6-methylation of RNA by an RNA polymerase II-associated methyltransferase. 2019.01; 363 (6423): ( PubMed , DOI )

  1. Crystal structure of the Agrobacterium tumefaciens type VI effector-immunity complex. 2018.12; 74 (Pt 12): 810-816. ( PubMed , DOI )

  2. Vibrational and Molecular Properties of Mg2+ Binding and Ion Selectivity in the Magnesium Channel MgtE. 2018.10; 122 (42): 9681-9696. ( PubMed , DOI )

  3. An Atomistic Model of a Precursor State of Light-Induced Channel Opening of Channelrhodopsin. 2018.10; 115 (7): 1281-1291. ( PubMed , DOI )

  4. Kato K, Nishimasu H, Oikawa D, Hirano S, Hirano H, Kasuya G, Ishitani R, Tokunaga F, Nureki O: Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1. Nature communications. 2018.10; 9 (1): 4424. ( PubMed , DOI )

  5. Engineered CRISPR-Cas9 nuclease with expanded targeting space. 2018.09; 361 (6408): 1259-1262. ( PubMed , DOI )

  6. Free Energy Landscape for the Entire Transport Cycle of Triose-Phosphate/Phosphate Translocator. 2018.09; 26 (9): 1284-1296. ( PubMed , DOI )

  7. Cryo-EM structures of the human volume-regulated anion channel LRRC8. 2018.09; 25 (9): 797-804. ( PubMed , DOI )

  8. Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR. 2018.04; 7 ( PubMed , DOI )

  1. Structural basis for xenobiotic extrusion by eukaryotic MATE transporter. 2017.11; 8 (1): 1633. ( PubMed , DOI )

  2. Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel. 2017.10; 8 (1): 876. ( PubMed , DOI )

  3. Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity. 2017.10; 3 (10): 825-832. ( PubMed , DOI )

  4. Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6. 2017.08; 548 (7667): 356-360. ( PubMed , DOI )

  5. Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1. 2017.08; 67 (4): 633-645. ( PubMed , DOI )

  6. ATP-dependent modulation of MgtE in Mg2+ homeostasis. 2017.07; 8 (1): 148. ( PubMed , DOI )

  7. Structural Basis for the Altered PAM Recognition by Engineered CRISPR-Cpf1. 2017.07; 67 (1): 139-147. ( PubMed , DOI )

  8. Kato Kazuki, Omura Hiroki, Ishitani Ryuichiro, Nureki Osamu: Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA. Annu Rev Biochem. 2017.06; 86 541-566. ( PubMed , DOI )

  9. Structural insights into the nucleotide base specificity of P2X receptors. 2017.03; 7 45208. ( PubMed , DOI )

  10. Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems. 2017.03; 65 (6): 1109-1121. ( PubMed , DOI )

  11. Correction: Breakpoint Cluster Region-Mediated Inflammation Is Dependent on Casein Kinase II. 2017.01; 198 (2): 971. ( PubMed , DOI )

  1. Halik, A., Tilgner, M., Silva, P., Estrada, N., Altwasser, R., Jahn, E., Heuser, M., Hou, H. A., Pratcorona, M., Hills, R. K., Metzeler, K. H., Fenwarth, L., Dolnik, A., Terre, C., Kopp, K., Blau, O., Szyska, M., Christen, F., Kronke, J., Vasseur, L., Lowenberg, B., Esteve, J., Valk, P. J. M., Duchmann, M., Chou, W. C., Linch, D. C., Dohner, H., Gale, R. E., Dohner, K., Bullinger, L., Yoshida, K., Damm, F.: Genomic characterization of AML with aberrations of chromosome 7: a multinational cohort of 519 patients. J Hematol Oncol. 2004; 17 (1): 70. ( PubMed , DOI )

  1. Ishitani Ryuuitirou: Deep Learning for Drug Discovery Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2019; 92 3-CS4-3. ( DOI )

  1. 田中良樹, 氏原一哉, 坂井直樹, 山田悠介, 武本瑞貴, 森脇寛智, 佐藤匡史, STANFIELD Joshua Kyle, 梅本直, 平田邦生, 引田理英, 石谷隆一郎, 加藤龍一, 千田俊哉, 山本雅貴, 力丸健太郎, 西ヶ谷有輝: Structure Based Discovery of Novel ALS Inhibitors 日本農薬学会大会講演要旨集(CD-ROM). 2023; 48th

  1. 田中良樹, 氏原一哉, 坂井直樹, 武本瑞貴, 森脇寛智, 佐藤匡史, STANFIELD JK, 平田邦生, 竹下浩平, 石谷隆一郎, 山本雅貴, 力丸健太郎, 西ヶ谷有輝: Structure Based Discovery of Novel ALS Inhibitors 日本農薬学会大会講演要旨集(CD-ROM). 2022; 47th

  1. 小野田浩宜, 石谷隆一郎, 仙石徹, 森脇由隆: The Impact of AlphaFold on Molecular Biology 日本分子生物学会年会プログラム・要旨集(Web). 2021; 44th

  2. 石谷隆一郎, 石谷隆一郎, 武本瑞貴: AlphaFold from the perspective of structural biology and deep learning 日本分子生物学会年会プログラム・要旨集(Web). 2021; 44th

  1. Taniguchi Reiya, Inoue Asuka, Sayama Misa, Yamashita Keitaro, Hirata Kunio, Yoshida Masahito, Nakada-Nakura Yoshiko, Otani Yuko, Kato Hideaki, Nishizawa Tomohiro, Doi Takayuki, Ohwada Tomohiko, Ishitani Ryuichiro, Aoki Junken, Nureki Osamu: Toward Structural Understanding of Ligand Recognition by Lysophosphatidic Acid Receptor Lpa6 PROTEIN SCIENCE. 2018.11; 27 235-236.

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