Kobayakawa T, Arioka M, Yamamoto K, Tsuji K, Tamamura H: Diastereoselective synthesis of (Z)-fluoroalkene dipeptide isosteres utilizing chiral auxiliaries Org Biomol Chem. 2025.05; 23 (18): 4333-4336. ( PubMed , DOI )

Takuya Kobayakawa, Kenichi Yamamoto, Aiichiro Fukutome, Marisa Arioka, Kohei Tsuji, Hirokazu Tamamura: Design and synthesis of a C2-symmetric cyclic decapeptide and its peptidomimetic as potential inhibitors against amyloid-beta aggregation. SYNLETT. 2025.04; 36 (17): 2948-2952. ( DOI )

Shinohara K, Kobayakawa T, Tsuji K, Takamatsu Y, Mitsuya H, Tamamura H: Naphthalen-1-ylethanamine-containing small molecule inhibitors of the papain-like protease of SARS-CoV-2. European journal of medicinal chemistry. 2024.12; 280 116963. ( PubMed , DOI )

Kobayakawa Takuya, Yokoyama Masaru, Tsuji Kohei, Boku Sayaka, Kurakami Masaki, Fujino Masayuki, Ishii Takahiro, Miura Yutaro, Nishimura Soshi, Shinohara Kouki, Yamamoto Kenichi, Bolah Peter, Kotani Osamu, Murakami Tsutomu, Sato Hironori, Tamamura Hirokazu: HIV-1カプシド蛋白質を標的とする低分子抗HIV-1薬の開発(Development of Small-Molecule Anti-HIV-1 Agents Targeting HIV-1 Capsid Proteins) Chemical & Pharmaceutical Bulletin. 2024.01; 72 (1): 41-47. ( ichushi )

Kobayakawa T, Yokoyama M, Tsuji K, Boku S, Kurakami M, Fujino M, Ishii T, Miura Y, Nishimura S, Shinohara K, Yamamoto K, Bolah P, Kotani O, Murakami T, Sato H, Tamamura H: Development of Small-Molecule Anti-HIV-1 Agents Targeting HIV-1 Capsid Proteins. Chemical & pharmaceutical bulletin. 2024; 72 (1): 41-47. ( PubMed , DOI )

Kohei Tsuji, Takuya Kobayakawa, Takahiro Ishii, Nobuyo Higashi-Kuwata, Chika Azuma, Kouki Shinohara, Yutaro Miura, Kenichi Yamamoto, Soshi Nishimura, Shin-ichiro Hattori, Haydar Bulut, Hiroaki Mitsuya, Hirokazu Tamamura: Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement. Chemical and Pharmaceutical Bulletin. 2023.12; 71 (12): 879-886. ( PubMed , DOI )

Tsuji Kohei, Kobayakawa Takuya, Ishii Takahiro, Higashi-Kuwata Nobuyo, Azuma Chika, Shinohara Kouki, Miura Yutaro, Yamamoto Kenichi, Nishimura Soshi, Hattori Shin-ichiro, Bulut Haydar, Mitsuya Hiroaki, Tamamura Hirokazu: ハロゲン導入およびアミド結合置換によるSARS-CoV-2のメインプロテアーゼに有効な阻害薬の探索研究(Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement) Chemical & Pharmaceutical Bulletin. 2023.12; 71 (12): 879-886. ( ichushi )

Takuya Kobayakawa, Masayuki Amano, Miyuki Nakayama, Kohei Tsuji, Takahiro Ishii, Yutaro Miura, Kouki Shinohara, Kenichi Yamamoto, Masao Matsuoka, Hirokazu Tamamura: Development of anti-HBV agents targeting HBV capsid proteins. RSC Medicinal Chemistry. 2023.10; 14 (10): 1973-1980. ( PubMed , DOI )

Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Kouki Shinohara, Chika Azuma, Yutaro Miura, Hiroki Nakano, Naoya Wada, Shin-ichiro Hattori, Haydar Bulut, Hiroaki Mitsuya, Hirokazu Tamamura: Structure-Activity Relationship Studies of SARS-CoV-2 Main Protease Inhibitors Containing 4-Fluorobenzothiazole-2-carbonyl Moieties. Journal of Medicinal Chemistry. 2023.10; 66 (19): 13516-13529. ( PubMed , DOI )

Tsuji K, Baffour-Awuah Owusu K, Miura Y, Ishii T, Shinohara K, Kobayakawa T, Emi A, Nakano T, Suzuki Y, Tamamura H: Dimerized fusion inhibitor peptides targeting the HR1-HR2 interaction of SARS-CoV-2. RSC advances. 2023.03; 13 (13): 8779-8793. ( PubMed , DOI )

Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nobuyo Higashi-Kuwata, Chika Azuma, Miyuki Nakayama, Takato Onishi, Hiroki Nakano, Naoya Wada, Miki Hori, Kouki Shinohara, Yutaro Miura, Takuma Kawada, Hironori Hayashi, Shin-Ichiro Hattori, Haydar Bulut, Debananda Das, Nobutoki Takamune, Naoki Kishimoto, Junji Saruwatari, Tadashi Okamura, Kenta Nakano, Shogo Misumi, Hiroaki Mitsuya, Hirokazu Tamamura: Potent and biostable inhibitors of the main protease of SARS-CoV-2. iScience. 2022.11; 105365. ( PubMed , DOI )