Tomoya Sakuma , Yuki Otani , Hideyuki Shimizu: Geometric-Evolutionary Deep Learning Decodes the Human GPCR-Metabolome Interactome and Enables Systematic De-Orphanization bioRxiv. 2026.02; ( DOI )

Takumi Ito, Kohei Ota, Hidekazu Hishinuma, Hideyuki Shimizu: A Functional Atlas of the Tardigrade Resistome Reveals a Diverse Molecular Toolkit for Extremotolerance bioRxiv. 2025.06; ( DOI )

Takumi Ito, Satoshi Ohno, Yiran Wang, Saori Uematsu, Shinya Kuroda, Hideyuki Shimizu: MetDeeCINE: Deciphering Metabolic Regulation through Deep Learning and Multi-Omics 2025.03; ( DOI )

Molecular characteristic analysis of single-nucleotide polymorphisms in SLC16A9/hMCT9. 2023.12; 334 122205. ( PubMed , DOI )

Atorvastatin Exerts More Selective Inhibitory Effects on hMCT2 than on hMCT1 and hMCT4. 2023.07; 43 (7): 3015-3022. ( PubMed , DOI )

Monocarboxylate transporter 4 involves in energy metabolism and drug sensitivity in hypoxia. 2023.01; 13 (1): 1501. ( PubMed , DOI )

Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l-lactate transport in the hepatocellular carcinoma cell line. 2022.10; 43 (5): 183-191. ( PubMed , DOI )

Pan–Pharmacological Drug–Target Interaction Prediction with 3D–Informed Protein Encoding at Scale 2026.04;

Tomoya Sakuma, Yuki Otani, Hideyuki Shimizu: High-Resolution Mapping of the Human E3-Substrate Interactome using Ubicon Uncovers Network Architecture and Cancer Vulnerabilities bioRxiv. 2025.04; ( DOI )

Yuki Otani, Daisuke Koga, Yasunari Wakizaka, Hideyuki Shimizu: BaCNet: Deep Learning Accelerates Novel Antibiotic Discovery Against Resistant Pathogens bioRxiv. 2025.03; ( DOI )

Yuki Otani, Daisuke Koga, Yasunari Wakizaka, Hideyuki Shimizu: AMP-Atlas: Comprehensive Atlas of Antimicrobial Peptides to Combat Multidrug-resistant Bacteria bioRxiv. 2025.03; ( DOI )

Monocarboxylate Transporters 1 and 2 Are Responsible for L-Lactate Uptake in Differentiated Human Neuroblastoma SH-SY5Y Cells 2024.04; 47 (4): 764-770. ( DOI )