Department of Nephrology

191  articles.  
* There may be some overlapped articles listed due to the difference of format.

  1. Nakano Y, Mandai S*, Mori Y, Ando F, Susa K, Mori T, Iimori S, Naito S, Sohara E, Fushimi K, Uchida S.: Cognitive Impairment and Physical Dysfunction Associated With Unplanned Dialysis Initiation Kidney International Reports. 2025.04;

  2. Mori M, Mori Y, Nakao Y, Mandai S, Fujiki T, Kikuchi H, Ando F, Susa K, Mori T, Waseda Y, Yoshida S, Fujii Y, Sohara E, Uchida S: Development of Adult Renal Tubular Organoids from Different Human Individuals in a Single Medium. JMA journal. 2025.01; 8 (1): 191-197. ( PubMed , DOI )

  1. Takayasu Mori, Takuya Fujimaru, Chunyu Liu, Karynne Patterson, Kouhei Yamamoto, Takefumi Suzuki, Motoko Chiga, Akinari Sekine, Yoshifumi Ubara, Danny E Miller, Miranda P G Zalusky, Shintaro Mandai, Fumiaki Ando, Yutaro Mori, Hiroaki Kikuchi, Koichiro Susa, , Jessica X Chong, Michael J Bamshad, Yue-Qiu Tan, Feng Zhang, Shinichi Uchida, Eisei Sohara: CFAP47 is Implicated in X-Linked Polycystic Kidney Disease. Kidney Int Rep. 2024.12; 9 (12): 3580-3591. ( PubMed , DOI )

  2. Yuta Nakano, Shintaro Mandai, Yutaro Mori, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Soichiro Iimori, Shotaro Naito, Eisei Sohara, Kiyohide Fushimi, Shinichi Uchida: Nationwide mortality following acute type B aortic dissection and the survival advantage of obesity among dialysis patients in Japan. J Nephrol. 2024.11; ( PubMed , DOI )

  3. Yanagi, T; Kikuchi, H; Takeuchi, K; Susa, K; Mori, T; Chiga, M; Yamamoto, K; Furukawa, A; Kanazawa, T; Kato, Y; Takahashi, N; Suzuki, T; Mori, Y; Carter, BC; Mori, M; Nakano, Y; Fujiki, T; Hara, Y; Suzuki, S; Ando, F; Mandai, S; Honda, S; Torii, S; Shimizu, S; Tanaka, H; Fujii, Y; Rai, T; Uchida, S; Sohara, E: ULK1-regulated AMP sensing by AMPK and its application for the treatment of chronic kidney disease KIDNEY INTERNATIONAL. 2024.11; 106 (5): 887-906. ( PubMed , DOI )

  4. Fujimaru T, Mori T, Sekine A, Chiga M, Mandai S, Kikuchi H, Mori Y, Hara Y, Fujiki T, Ando F, Susa K, Iimori S, Naito S, Hanazawa R, Hirakawa A, Mochizuki T, Suwabe T, Ubara Y, Uchida S, Sohara E: Importance of IFT140 in Patients with Polycystic Kidney Disease Without a Family History. Kidney international reports. 2024.09; 9 (9): 2685-2694. ( PubMed , DOI )

  5. Adult renal tubular organoids can be produced from different human individuals in a completely same protocol 2024.08; 2024.08.11.24311846 ( DOI )

  6. Hara M, Mandai S*, Mori T, Maejima Y, Uchida S: Takayasu arteritis manifesting as acute kidney injury and congestion due to renal artery stenosis and myocarditis: a case report. Eur Heart J Case Rep. 2024.08; 8 (8): ytae347. ( PubMed , DOI )

  7. Yuta Nakano, Shintaro Mandai, Daiei Takahashi, Ken Ikenouchi, Yutaro Mori, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Soichiro Iimori, Shotaro Naito, Eisei Sohara, Kiyohide Fushimi, Shinichi Uchida: Sex disparities in the risk of urgent dialysis following acute aortic dissections in Japan. iScience. 2024.08; 27 (8): 110577. ( PubMed , DOI )

  8. Sex Disparities in the Risk of Urgent Dialysis Following Acute Aortic Dissections in Japan: A Real-World Naitionwide Study 2024.05; ( DOI )

  9. Fujimaru T, Mori T, Chiga M, Mandai S, Kikuchi H, Ando F, Mori Y, Susa K, Nakano Y, Shoji T, Fukudome Y, Inaba N, Kitamura K, Nakanishi T, Uchida K, Kimura T, Tamura T, Ozawa K, Uchida S, Sohara E: Genetic Diagnosis of Adult Hemodialysis Patients With Unknown Etiology. Kidney international reports. 2024.04; 9 (4): 994-1004. ( PubMed , DOI )

  10. Mori T, Fujimaru T, Liu C, Patterson K, Yamamoto K, Suzuki T, Chiga M, Sekine A, Ubara Y, Miller DE, Zalusky MP, Mandai S, Ando F, Mori Y, Kikuchi H, Susa K, University of Washington Center for Rare Disease Research, Chong JX, Bamshad MJ, Tan YQ, Zhang F, Uchida S, Sohara E: CFAP47 is a novel causative gene implicated in X-linked polycystic kidney disease. medRxiv : the preprint server for health sciences. 2024.04; ( PubMed , DOI )

  11. Nobuhisa Morimoto, Shingo Shioji, Yuichiro Akagi, Tamami Fujiki, Shintaro Mandai, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Shotaro Naito, Eisei Sohara, Tatsuhiko Anzai, Kunihiko Takahashi, Wataru Akita, Akihito Ohta, Shinichi Uchida, Soichiro Iimori: Associations between dietary potassium intake from different food sources and hyperkalemia in patients with chronic kidney disease. Journal of Renal Nutrition. 2024.04; ( PubMed , DOI )

  12. Yuki Nakao, Yutaro Mori, Makiko Mori, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida: Recapitulation of Cellular Senescence, Inflammation, and Fibrosis in Human Kidney-Derived Tubuloids by Repeated Cisplatin Treatment medRxiv. 2024.03; 2024.03.17.24304404. ( DOI )

  13. Ikenouchi K, Takahashi D, Mandai S*, Watada M, Koyama S, Hoshino M, Takahashi N, Shoda W, Kuyama T, Mori Y, Ando F, Susa K, Mori T, Iimori S, Naito S, Sohara E, Fushimi K, Uchida S: Impact of COVID-19 versus other pneumonia on in-hospital mortality and functional decline among Japanese dialysis patients: a retrospective cohort study. Sci Rep. 2024.03; 14 (1): 5177. ( PubMed , DOI )

  14. Rena Suzukawa, Shintaro Mandai, Yuta Nakano, Shunsuke Inaba, Hisazumi Matsuki, Yutaro Mori, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Shotaro Naito, Eisei Sohara, Tatemitsu Rai, Kiyohide Fushimi, Shinichi Uchida: Association between antihypertensive combinations and postoperative mortality and functional decline: a nationwide survey of Japanese adults undergoing major surgeries medRxiv. 2024.03; 2024.03.14.24304265.

  15. Hashimoto H, Mandai S*, Shikuma S, Kimura M, Toma H, Sakaguchi Y, Kimura M, Ota J, Chiba Y, Sakai K, Horiuchi S, Adachi S, Uchida S.: Hypoxia-inducible factor prolyl hydroxylase domain inhibitors may mitigate loss of skeletal muscle mass in haemodialysis patients JCSM Rapid Commun. 2024.01;

  1. Yanagawa H, Hara Y, Ando F, Suzuki S, Fujiki T, Oikawa D, Yui N, Mandai S, Mori Y, Susa K, Mori T, Sohara E, Tokunaga F, Uchida S: LRBA signalosomes activate vasopressin-induced AQP2 trafficking at recycling endosomes. The Journal of physiology. 2023.12; 601 (23): 5437-5451. ( PubMed , DOI )

  2. Yuta Nakano, Shintaro Mandai, Shotaro Naito, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Eisei Sohara, Shinichi Uchida: Effect of osteosarcopenia on longitudinal mortality risk and chronic kidney disease progression in older adults. Bone. 2023.11; 116975. ( PubMed , DOI )

  3. Hashimoto H, Mandai S*, Shikuma S, Kimura M, Toma H, Sakaguchi Y, Shiraishi S, Toshima N, Hoshino M, Kimura M, Ota J, Horiuchi S, Adachi S, Uchida S: The effect of antihypertensive therapy on skeletal muscle mass and bone mineral density in patients with end-stage kidney disease. J Ren Nutr. 2023.10; ( PubMed , DOI )

  4. Discovery of a Novel Candidate Gene Implicated in X-Linked Polycystic Kidney Disease 2023.10; 34 (Abstract Supplement): 941.

  5. Monoallelic IFT140 Pathogenic Variants in Adult Polycystic Kidney Disease Patients Without Family History 2023.10; 34 (Abstract Supplementtrack): 944.

  6. LRBA Signalosomes Activate Vasopressin-Induced AQP2 Trafficking at Recycling Endosomes 2023.10; 34 (Abstract Supplementppleme): 543.

  7. Screening for Small-Molecule Inhibitor for KIM-1 and Its Functional Validation in Kidney Fibrosis 2023.10; 34 (Abstract Supplementt): 840.

  8. Hisazumi Matsuki, Shintaro Mandai*, Hiroki Shiwaku, Takaaki Koide, Naohiro Takahashi, Tomoki Yanagi, Shunsuke Inaba, Saaya Ida, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Eisei Sohara, Hidehiko Takahashi, Shinichi Uchida: Chronic kidney disease causes blood-brain barrier breakdown via urea-activated matrix metalloproteinase-2 and insolubility of tau protein. Aging (Albany NY). 2023.10; 15 ( PubMed , DOI )

  9. Association Among Bone Mass, Muscle Mass and Strength, Mortality, and CKD Progression in Older Adults 2023.10; 34 (Abstract Supplement): 125.

  10. Tubuloids on Primary Human Renal Tubular Epithelial Cells (hRTECs) Recapitulates Cisplatin-Induced Kidney Injury 2023.10; 34 (Abstract Supplement): 722.

  11. The Transcriptomic Landscape of microRNAs Encapsulated in Circulat- ing Extracellular Vesicles and CKD Progression in Japanese Adults 2023.10; 34 (Abstract Supplement): 663.

  12. Hisazumi Matsuki, Taku Genma, Shintaro Mandai*, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Shotaro Naito, Eisei Sohara, Tatemitsu Rai, Kiyohide Fushimi, Shinichi Uchida: National Trends in Mortality and Urgent Dialysis after Acute Hypertension in Japan From 2010 Through 2019. Hypertension. 2023.10; ( PubMed , DOI )

  13. Shintaro Mandai, Takaaki Koide, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Soichiro Iimori, Shotaro Naito, Eisei Sohara, Shinichi Uchida, Kiyohide Fushimi, Tatemitsu Rai: Association of Admission Functional Status and Body Mass Index with Mortality in Patients Receiving Chronic Dialysis: A Nationwide Observational Cohort Study. JMA J. 2023.10; 6 (4): 404-413. ( PubMed , DOI )

  14. National Trends in Mortality and Urgent Dialysis after Admission for Acute Hypertension in Japan from 2010 through 2019 2023.08; 2023.08.07.23293627. ( DOI )

  15. ULK1-regulated AMP sensing by AMPK and its application for the treatment of chronic kidney disease 2023.08; 2023.08.09.552390. ( DOI )

  16. Fumiaki Ando, Yu Hara, Shinichi Uchida: Identification of protein kinase A signalling molecules in renal collecting ducts. J Physiol. 2023.04; 602 (13): 3057-3067. ( PubMed , DOI )

  17. Morimoto N, Mori T, Shioji S, Taguchi T, Watanabe H, Sakai K, Mori K, Yamamura A, Hanioka A, Akagi Y, Fujiki T, Mandai S, Mori Y, Ando F, Susa K, Iimori S, Naito S, Sohara E, Ohashi K, Uchida S: Rapidly progressive IgA nephropathy with membranoproliferative glomerulonephritis-like lesions in an elderly man following the third dose of an mRNA COVID-19 vaccine: a case report. BMC nephrology. 2023.04; 24 (1): 108. ( PubMed , DOI )

  18. Nobuhisa Morimoto, Takayasu Mori, Shingo Shioji, Hatsumi Watanabe, Keigo Sakai, Katsuo Mori, Ayumi Yamamura, Asami Hanioka, Yuichiro Akagi, Tamami Fujiki, Shintaro Mandai, Yutaro Mori, Fumiaki Ando, Koichiro Susa, Soichiro Iimori, Shotaro Naito, Eisei Sohara, Shinichi Uchida: Thrombocytopenia during avacopan administration: A case report. International Journal of Rheumatic Diseases. 2023.03; ( PubMed , DOI )

  19. Soichiro Suzuki, Fumiaki Ando, Sae Kitagawa, Yu Hara, Tamami Fujiki, Shintaro Mandai, Koichiro Susa, Takayasu Mori, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida: ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells. Commun Biol. 2023.01; 6 (1): 29. ( PubMed , DOI )

  20. Takaaki Koide, Shintaro Mandai*, Reo Kitaoka, Hisazumi Matsuki, Motoko Chiga, Kouhei Yamamoto, Kotaro Yoshioka, Yohsuke Yagi, Soichiro Suzuki, Tamami Fujiki, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Shotaro Naito, Eisei Sohara, Tatemitsu Rai, Takanori Yokota, Shinichi Uchida: Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease. Circ Res. 2023.01; ( PubMed , DOI )

  21. Susa K, Kobayashi K, Galichon P, Matsumoto T, Tamura A, Hiratsuka K, Gupta NR, Yazdi IK, Bonventre JV, Morizane R: ATP/ADP biosensor organoids for drug nephrotoxicity assessment. Frontiers in cell and developmental biology. 2023; 11 1138504. ( PubMed , DOI )

  22. Kurimoto Junki, Takagi Hiroshi, Miyata Takashi, Kawaguchi Yohei, Hodai Yuichi, Tsumura Tetsuro, Hagiwara Daisuke, Kobayashi Tomoko, Yasuda Yoshinori, Sugiyama Mariko, Onoue Takeshi, Iwama Shintaro, Suga Hidetaka, Banno Ryoichi, Katsuki Takeshi, Ando Fumiaki, Uchida Shinichi, Arima Hiroshi: Mineralocorticoids induce polyuria by reducing apical aquaporin-2 expression of the kidney in partial vasopressin deficiency ENDOCRINE JOURNAL. 2023; 70 (3): 295-304.

  1. Erfinanda, L; Zou, L; Gutbier, B; Kneller, L; Weidenfeld, S; Michalick, L; Lei, DS; Reppe, K; Alves, LGT; Schneider, B; Zhang, Q; Li, CH; Fatykhova, D; Schneider, P; Liedtke, W; Sohara, E; Mitchell, TJ; Gruber, AD; Hocke, A; Hippenstiel, S; Suttorp, N; Olschewski, A; Mall, MA; Witzenrath, M; Kuebler, WM: Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation SCIENCE TRANSLATIONAL MEDICINE. 2022.12; 14 (674): eabg8577. ( PubMed , DOI )

  2. Maho Hatano, Tomohiro Udagawa, Toru Kanamori, Akito Sutani, Takayasu Mori, Eisei Sohara, Shinichi Uchida, Tomohiro Morio, Masato Nishioka: A novel SLC5A2 heterozygous variant in a family with familial renal glucosuria Hum Genome Var. 2022.12; 9 (1): 42. ( PubMed , DOI )

  3. Yanagi T, Kikuchi H, Susa K, Takahashi N, Bamba H, Suzuki T, Nakano Y, Fujiki T, Mori Y, Ando F, Mandai S, Mori T, Takeuchi K, Honda S, Torii S, Shimizu S, Rai T, Uchida S, Sohara E: Absence of ULK1 decreases AMPK activity in the kidney, leading to chronic kidney disease progression. Genes to cells. 2022.11; 28 (1): 5-14. ( PubMed , DOI )

  4. Kidney Injury Molecule-1 (KIM-1) Shapes the Kidney Immune Microenvironment via Lymphotoxin Beta Receptor (LTbR) Signaling 2022.10; 33 (Abstract Supplement): 22.

  5. Underlying Genetic Causes of Adult Patients With ESKD Undergoing Hemodialysis Therapy 2022.10; 33 (Abstract Supplement): 755.

  6. Small Molecule Screening Identifies TW-37 as a KIM-1 Inhibitor and Potential Anti-Fibrotic Molecule 2022.10; 33 (Abstract Supplement): 106.

  7. Nakano Y, Mandai S*, Genma T, Akagi Y, Fujiki T, Ando F, Susa K, Mori T, Iimori S, Naito S, Sohara E, Uchida S, Fushimi K, Rai T*.: Nationwide mortality associated with perioperative acute dialysis requirement in major surgeries. Int J Surg. 2022.08; 104 106816. ( PubMed , DOI )

  8. Hara Y, Ando F, Oikawa D, Ichimura K, Yanagawa H, Sakamaki Y, Nanamatsu A, Fujiki T, Mori S, Suzuki S, Yui N, Mandai S, Susa K, Mori T, Sohara E, Rai T, Takahashi M, Sasaki S, Kagechika H, Tokunaga F, Uchida S: LRBA is essential for urinary concentration and body water homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 2022.07; 119 (30): e2202125119. ( PubMed , DOI )

  9. Iio K, Mori T, Bessho S, Imai Y, Hatanaka M, Omori H, Kouhara H, Chiga M, Sohara E, Uchida S, Kaimori JY: Gitelman syndrome with a novel frameshift variant in SLC12A3 gene accompanied by chronic kidney disease and type 2 diabetes mellitus. CEN case reports. 2022.05; 11 (2): 191-195. ( PubMed , DOI )

  10. Gupta N, Matsumoto T, Hiratsuka K, Garcia Saiz E, Galichon P, Miyoshi T, Susa K, Tatsumoto N, Yamashita M, Morizane R: Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair. Science translational medicine. 2022.03; 14 (634): eabj4772. ( PubMed , DOI )

  11. Jialing Liu, Yi Li, Lingna Lyu, Liang Xiao, Aliza A Memon, Xin Yu, Arvin Halim, Shivani Patel, Abdikheyre Osman, Wenqing Yin, Jie Jiang, Said Naini, Kenneth Lim, Aifeng Zhang, Jonathan D Williams, Ruth Koester, Kevin Z Qi, Quynh-Anh Fucci, Lai Ding, Steven Chang, Ankit Patel, Yutaro Mori, Advika Chaudhari, Aaron Bao, Jia Liu, Tzong-Shi Lu, Andrew Siedlecki: Integrin α5 Is Regulated by miR-218-5p in Endothelial Progenitor Cells. J Am Soc Nephrol. 2022.03; 33 (3): 565-582. ( PubMed , DOI )

  12. Nakano Y, Susa K, Yanagi T, Hiraoka Y, Suzuki T, Mori T, Ando F, Mandai S, Fujiki T, Rai T, Uchida S, Sohara E.: Generation of NPHP1 knockout human pluripotent stem cells by a practical biallelic gene deletion strategy using CRISPR/Cas9 and ssODN. In Vitro Cell Dev Biol Anim. 2022.02; 58 (2): 85-95. ( PubMed , DOI )

  13. Yutaro Mori, Corby Fink, Takaharu Ichimura, Keisuke Sako, Makiko Mori, Nathan N Lee, Philipp Aschauer, Krishna M Padmanabha Das, SoonGweon Hong, Minsun Song, Robert F Padera, Astrid Weins, Luke P Lee, Mahmoud L Nasr, Gregory A Dekaban, Jimmy D Dikeakos, Joseph V Bonventre: KIM-1/TIM-1 is a Receptor for SARS-CoV-2 in Lung and Kidney. medRxiv. 2022.01; 2020.09.16.20190694 ( PubMed , DOI )

  14. Adya Saran Sinha, Tianying Wang, Miho Watanabe, Yasushi Hosoi, Eisei Sohara, Tenpei Akita, Shinichi Uchida, Atsuo Fukuda: conductance in layer V pyramidal neurons of mouse medial prefrontal cortex. Front Mol Neurosci. 2022; 15 856262. ( PubMed , DOI )

  15. Shinichi Uchida, Takayasu Mori, Koichiro Susa, Eisei Sohara: NCC regulation by WNK signal cascade. Front Physiol. 2022; 13 1081261. ( PubMed , DOI )

  16. Suzuki Minami, Sekiguchi Yuta, Sasaki Masato, Inaba Shunsuke, Oyama Sakino, Inoue Yuichi, Warabi Masahiro, Ohashi Kenichi, Inoshita Seiji: Antineutrophil Cytoplasmic Antibody-associated Vasculitis after COVID-19 Vaccination with Pfizer-BioNTech. Intern Med. 2022; 61 (19): 2925-2929. ( PubMed , DOI )

  1. Shintaro Mandai, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Shotaro Naito, Eisei Sohara, Shinichi Uchida, Kiyohide Fushimi, Tatemitsu Rai: Burden of kidney disease on the discrepancy between reasons for hospital admission and death: An observational cohort study. PLoS One. 2021.11; 16 (11): e0258846. ( PubMed , DOI )

  2. Ando F: Activation of AQP2 water channels by protein kinase A: therapeutic strategies for congenital nephrogenic diabetes insipidus. Clinical and experimental nephrology. 2021.10; 25 (10): 1051-1056. ( PubMed , DOI )

  3. Kumagai A, Takeda S, Sohara E, Uchida S, Iijima H, Itakura A, Koya D, Kanasaki K: Dietary Magnesium Insufficiency Induces Salt-Sensitive Hypertension in Mice Associated With Reduced Kidney Catechol-O-Methyl Transferase Activity. Hypertension (Dallas, Tex. : 1979). 2021.07; 78 (1): 138-150. ( PubMed , DOI )

  4. Christian Wiraja, Yutaro Mori, Takaharu Ichimura, Jangsun Hwang, Chenjie Xu, Joseph V Bonventre: Nephrotoxicity Assessment with Human Kidney Tubuloids using Spherical Nucleic Acid-Based mRNA Nanoflares. Nano Lett. 2021.07; 21 (13): 5850-5858. ( PubMed , DOI )

  5. Nanamatsu A, Mori T, Ando F, Furusho T, Mandai S, Susa K, Sohara E, Rai T, Uchida S.: Vasopressin Induces Urinary Uromodulin Secretion By Activating PKA (Protein Kinase A). Hypertension. 2021.06; 77 (6): 1953-1963. ( PubMed , DOI )

  6. Shimohata H, Miyake Y, Yoshida Y, Usui J, Mori T, Sohara E, Uchida S, Hirayama K, Kobayashi M: LMX1B-associated nephropathy that showed myelin figures on electron microscopy. CEN case reports. 2021.06; 10 (4): 588-591. ( PubMed , DOI )

  7. Li Li, Pierre Galichon, Xiaoyan Xiao, Ana C Figueroa-Ramirez, Diana Tamayo, Jake J-K Lee, Marian Kalocsay, David Gonzalez-Sanchez, Maria S Chancay, Kyle W McCracken, Nathan N Lee, Takaharu Ichimura, Yutaro Mori, M Todd Valerius, Julia Wilflingseder, Dario R Lemos, Elazer R Edelman, Joseph V Bonventre: Orphan nuclear receptor COUP-TFII enhances myofibroblast glycolysis leading to kidney fibrosis. EMBO Rep. 2021.06; 22 (6): e51169. ( PubMed , DOI )

  8. Takuya Fujimaru, Kunio Kawanishi, Takayasu Mori, Eikan Mishima, Akinari Sekine, Motoko Chiga, Masayuki Mizui, Noriaki Sato, Motoko Yanagita, Yuki Ooki, Kiyotaka Nagahama, Yuko Ohnuki, Naoto Hamano, Saki Watanabe, Toshio Mochizuki, Katsushi Nagatsuji, Kenichi Tanaka, Tatsuo Tsukamoto, Hideo Tsushima, Mamiko Shimamoto, Takahiro Tsuji, Tamaki Kuyama, Shinya Kawamoto, Kenji Maki, Ai Katsuma, Mariko Oishi, Kouhei Yamamoto, Shintaro Mandai, Hiroaki Kikuchi, Fumiaki Ando, Yutaro Mori, Koichiro Susa, Soichiro Iimori, Shotaro Naito, Tatemitsu Rai, Junichi Hoshino, Yoshifumi Ubara, Mariko Miyazaki, Michio Nagata, Shinichi Uchida, Eisei Sohara: Genetic Background and Clinicopathologic Features of Adult-onset Nephronophthisis. Kidney Int Rep. 2021.05; 6 (5): 1346-1354. ( PubMed , DOI )

  9. Takahashi Naohiro, Kikuchi Hiroaki, Usui Ayaka, Furusho Taisuke, Fujimaru Takuya, Fujiki Tamami, Yanagi Tomoki, Matsuura Yoshiaki, Asano Kenichi, Yamamoto Kouhei, Ando Fumiaki, Susa Koichiro, Mandai Shintaro, Mori Takayasu, Rai Tatemitsu, Uchida Shinichi, Arita Makoto, Sohara Eisei: Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD2 in the kidney Clinical and Experimental Nephrology. 2021.05; 25 (5): 445-455. ( ichushi )

  10. Takedani K, Notsu M, Koike S, Yamauchi M, Mori T, Sohara E, Yamauchi A, Yoshikane K, Ito T, Kanasaki K: Osteomalacia caused by atypical renal tubular acidosis with vitamin D deficiency: a case report. CEN case reports. 2021.05; 10 (2): 294-300. ( PubMed , DOI )

  11. Yutaro Mori, Amrendra K Ajay, Jae-Hyung Chang, Shan Mou, Huiping Zhao, Seiji Kishi, Jiahua Li, Craig R Brooks, Sheng Xiao, Heung-Myong Woo, Venkata S Sabbisetti, Suetonia C Palmer, Pierre Galichon, Li Li, Joel M Henderson, Vijay K Kuchroo, Julie Hawkins, Takaharu Ichimura, Joseph V Bonventre: KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease. Cell Metab. 2021.05; 33 (5): 1042-1061.e7. ( PubMed , DOI )

  12. Mandai S, Yamada T, Uchihara T, Iida T, Ito T, Sato H, Sato K, Chida Y, Hirokawa K, Noda Y: Severe Dialysis-Related Amyloidosis Spared the Brain: An Autopsy Case of a Patient Receiving Hemodialysis for 41 Years. Journal of neuropathology and experimental neurology. 2021.03; ( PubMed , DOI )

  13. Takahashi N, Kikuchi H, Usui A, Furusho T, Fujimaru T, Fujiki T, Yanagi T, Matsuura Y, Asano K, Yamamoto K, Ando F, Susa K, Mandai S, Mori T, Rai T, Uchida S, Arita M, Sohara E: Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD2 in the kidney. Clinical and experimental nephrology. 2021.02; ( PubMed , DOI )

  14. Hashimoto H, Shikuma S, Mandai S*, Adachi S, Uchida S.: Calcium-based phosphate binder use is associated with lower risk of osteoporosis in hemodialysis patients SCIENTIFIC REPORTS. 2021.01; 11 (1): 1648. ( PubMed , DOI )

  1. Takayasu Mori, Motoko Chiga, Takuya Fujimaru, Ryosuke Kawamoto, Shintaro Mandai, Azuma Nanamatsu, Naohiro Nomura, Fumiaki Ando, Koichiro Susa, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida: Phenotypic differences of mutation-negative cases in Gitelman syndrome clinically diagnosed in adulthood. Hum Mutat. 2020.12; ( PubMed , DOI )

  2. Yohei Arai, Kenichi Asano, Shintaro Mandai, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Naohiro Nomura, Tatemitsu Rai, Masato Tanaka, Shinichi Uchida, Eisei Sohara: WNK1-TAK1 signaling suppresses lipopolysaccharide-induced cytokine production and classical activation in macrophages. Biochem Biophys Res Commun. 2020.12; 533 (4): 1290-1297. ( PubMed , DOI )

  3. Umene Ryusuke, Kitamura Mineaki, Arai Hideyuki, Matsumura Kazuki, Ishimaru Yuka, Maeda Kanenori, Uramatsu Tadashi, Obata Yoko, Mori Takayasu, Sohara Eisei, Uchida Shinichi, Nishino Tomoya: Bartter syndrome representing digenic-based salt-losing tubulopathies presumably accelerated by renal insufficiency(和訳中) CEN Case Reports. 2020.11; 9 (4): 375-379. ( ichushi )

  4. Takashi Iijima, Takayasu Mori, Eisei Sohara, Tatsuya Suwabe, Junichi Hoshino, Yoshifumi Ubara: A patient with congenital nephrogenic diabetes insipidus due to AVPR2 mutation complicated by persisting polydipsia under hemodialysis treatment. CEN Case Rep. 2020.10; ( PubMed , DOI )

  5. Ishii T, Fujimaru T, Nakano E, Takahashi O, Nakayama M, Yamauchi T, Komatsu Y: Association between chronic kidney disease and mortality in stage IV cancer. International journal of clinical oncology. 2020.09; 25 (9): 1587-1595. ( PubMed , DOI )

  6. Furusho T, Uchida S, Sohara E: The WNK signaling pathway and salt-sensitive hypertension Hypertension Research. 2020.08; 43 (8): 733-743. ( ichushi )

  7. Yutaro Mori, Amrendra K. Ajay, Jae-Hyung Chang, Shan Mou, Huiping Zhao, Seiji Kishi, Jiahua Li, Craig R. Brooks, Sheng Xiao, Heung-Myong Woo, Venkata S. Sabbisetti, Suetonia C. Palmer, Pierre Galichon, Li Li, Joel M. Henderson, Vijay K. Kuchroo, Takaharu Ichimura, Joseph V. Bonventre: KIM-1 Mediated Tubular Fatty Acid Uptake Leads to Progressive Diabetic Kidney Disease SSRN Electronic Journal (Sneak Peek 2.0, Cell Metabolism). 2020.07; ( DOI )

  8. Noda S, Mandai S*, Oda T, Shinoto T, Sato H, Sato K, Hirokawa K, Noda Y, Uchida S.: Asymptomatic sinusitis as an origin of infection-related glomerulonephritis manifesting steroid-resistant nephrotic syndrome: A case report. Medicine (Baltimore). 2020.06; 99 (25): e20572. ( PubMed , DOI )

  9. Li Li;Pierre Galichon;Xiaoyan Xiao;Ana C Figueroa-Ramirez;Diana Tamayo;Jake June-Koo Lee;Marian Kalocsay;David Gonzalez-Sanchez;Maria S Chancay;Kyle McCracken;Dario Lemos;Nathan Lee;Takaharu Ichimura;Yutaro Mori;M. Todd Valerius;Xiaoming Sun;Elazer R Edelman;Joseph V Bonventre: Orphan nuclear receptor COUP-TFII drives the myofibroblast metabolic shift leading to fibrosis bioRxiv. 2020.06; 2020.06.05.135889. ( DOI )

  10. Fujimaru Takuya, Sohara Eisei: Copy Number Variation: A New Genetic Form of Polycystic Kidney and Liver Disease KIDNEY INTERNATIONAL REPORTS. 2020.05; 5 (5): 575-576. ( PubMed , DOI )

  11. Xiaojie Wang, Jialing Liu, Wenqing Yin, Farhiya Abdi, Paul D Pang, Quynh-Anh Fucci, Molly Abbott, Steven L Chang, Graeme Steele, Ankit Patel, Yutaro Mori, Aifeng Zhang, Shikai Zhu, Tzong-Shi Lu, Adam S Kibel, Bin Wang, Kenneth Lim, Andrew M Siedlecki: miR-218 Expressed in Endothelial Progenitor Cells Contributes to the Development and Repair of the Kidney Microvasculature. Am J Pathol. 2020.03; 190 (3): 642-659. ( PubMed , DOI )

  12. Furusho T, Sohara E, Mandai S, Kikuchi H, Takahashi N, Fujimaru T, Hashimoto H, Arai Y, Ando F, Zeniya M, Mori T, Susa K, Isobe K, Nomura N, Yamamoto K, Okado T, Rai T, Uchida S: Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease. Kidney Int. 2020.02; 97 (4): 713-727. ( PubMed , DOI )

  13. Saito D, Fujimaru T, Inoue Y, Hirayama T, Ezaki I, Kin H, Shuo T, Nakayama M, Komatsu Y: Serial measurement of electrolyte and citrate concentrations in blood-primed continuous hemodialysis circuits during closed-circuit dialysis. Pediatric nephrology (Berlin, Germany). 2020.01; 35 (1): 127-133. ( PubMed , DOI )

  14. Mandai S, Sato H, Iimori S, Naito S, Tanaka H, Ando F, Susa K, Isobe K, Mori T, Nomura N, Sohara E, Okado T, Uchida S, Fushimi K, Rai T: Nationwide in-hospital mortality following major fractures among hemodialysis patients and the general population: An observational cohort study. Bone. 2020.01; 130 115122. ( PubMed , DOI )

  15. Shoda W, Nomura N, Ando F, Tagashira H, Iwamoto T, Ohta A, Isobe K, Mori T, Susa K, Sohara E, Rai T, Uchida S: Sodium-calcium exchanger 1 is the key molecule for urinary potassium excretion against acute hyperkalemia. PloS one. 2020; 15 (6): e0235360. ( PubMed , DOI )

  16. Fujimaru T, Shimada K, Hamada T, Watanabe K, Ito Y, Nagahama M, Taki F, Isokawa S, Hifumi T, Otani N, Nakayama M: Development of acute kidney injury with massive granular casts and microscopic hematuria in patients with COVID-19: two case presentations with literature review. Renal replacement therapy. 2020; 6 (1): 59. ( PubMed , DOI )

  1. Furuto Y, Kawamura M, Namikawa A, Takahashi H, Shibuya Y, Mori T, Sohara E: Non-urate transporter 1, non-glucose transporter member 9-related renal hypouricemia and acute renal failure accompanied by hyperbilirubinemia after anaerobic exercise: a case report. BMC nephrology. 2019.11; 20 (1): 433. ( PubMed , DOI )

  2. Seiji Kishi, Craig R Brooks, Kensei Taguchi, Takaharu Ichimura, Yutaro Mori, Akinwande Akinfolarin, Navin Gupta, Pierre Galichon, Bertha C Elias, Tomohisa Suzuki, Qian Wang, Leslie Gewin, Ryuji Morizane, Joseph V Bonventre: Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses. J Clin Invest. 2019.11; 129 (11): 4797-4816. ( PubMed , DOI )

  3. Ohkubo Atsushi, Okado Tomokazu, Sakurasawa Takatoshi, Maeda Takuma, Itagaki Ayako, Yamamoto Hiroko, Miyamoto Satoko, Seshima Hiroshi, Kurashima Naoki, Mori Takayasu, Iimori Soichiro, Sohara Eisei, Rai Tatemitsu, Uchida Shinichi, Naito Shotaro: Removal Characteristics of Immunoadsorption with the Tryptophan-Immobilized Column Using Conventional and Selective Plasma Separators in the Treatment of Myasthenia Gravis Therapeutic Apheresis and Dialysis. 2019.06; 23 (3): 271-278. ( ichushi )

  4. Fujiki T, Ando F*, Murakami K, Isobe K, Mori T, Susa K, Nomura N, Sohara E, Rai T, Uchida S: Tolvaptan activates the Nrf2/HO-1 antioxidant pathway through PERK phosphorylation Scientific Reports. 2019.06; 9 (1): 9245.

  5. Suzuki S, Naito S, Numasawa Y, Asada M, Shoji N, Zeniya M, Takahashi D, Sato H, Iimori S, Nomura N, Sohara E, Okado T, Ishiwata Y, Nagata M, Rai T, Yokota T, Uchida S: Encephalopathy Induced by High Plasma and Cerebrospinal Fluid Ceftriaxone Concentrations in a Hemodialysis Patient. Internal medicine (Tokyo, Japan). 2019.02; ( PubMed , DOI )

  6. Sekine A, Fujimaru T, Hoshino J, Suwabe T, Oguro M, Mizuno H, Kawada M, Sumida K, Hiramatsu R, Hasegawa E, Yamanouchi M, Hayami N, Mandai S, Chiga M, Kikuchi H, Ando F, Mori T, Sohara E, Uchida S, Sawa N, Takaichi K, Ubara Y: Genotype-Clinical Correlations in Polycystic Kidney Disease with No Apparent Family History. American journal of nephrology. 2019.02; 49 (3): 233-240. ( PubMed , DOI )

  1. Yoshida Sayaka, Araki Yuya, Mori Takayasu, Sasaki Emi, Kasagi Yuri, Isobe Kiyoshi, Susa Koichiro, Inoue Yuichi, Bomont Pascale, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi, Sohara Eisei: Decreased KLHL3 expression is involved in the pathogenesis of pseudohypoaldosteronism type II caused by cullin 3 mutation in vivo Clinical and Experimental Nephrology. 2018.12; 22 (6): 1251-1257. ( ichushi )

  2. Hiroaki Kikuchi, Eiichiro Kanda, Takayasu Mori, Hidehiko Sato, Soichiro Iimori, Naohiro Nomura, Shotaro Naito, Eisei Sohara, Tomokazu Okado, Shinichi Uchida, Kiyohide Fushimi, Tatemitsu Rai: Short-term prognosis of emergently hospitalized dialysis-independent chronic kidney disease patients: A nationwide retrospective cohort study in Japan. PLoS ONE. 2018.11; 13 (11): e0208258. ( PubMed , DOI )

  3. Kikuchi H, Sasaki E, Nomura N, Mori T, Minamishima YA, Yoshizaki Y, Takahashi N, Furusho T, Arai Y, Mandai S, Yamashita T, Ando F, Maejima Y, Isobe K, Okado T, Rai T, Uchida S, Sohara E: Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease. Kidney International. 2018.11; ( PubMed , DOI )

  4. Ayumi Matsumoto, Isao Matsui, Takayasu Mori, Yusuke Sakaguchi, Masayuki Mizui, Yoshiyasu Ueda, Atsushi Takahashi, Yohei Doi, Karin Shimada, Satoshi Yamaguchi, Keiichi Kubota, Nobuhiro Hashimoto, Tatsufumi Oka, Yoshitsugu Takabatake, Eisei Sohara, Takayuki Hamano, Shinichi Uchida, Yoshitaka Isaka: A Case of Severe Osteomalacia with Dent Disease Caused by a Novel Intronic Mutation of the CLCN5 gene. Intern. Med.. 2018.08; 57 (24): 3603-3610. ( PubMed , DOI )

  5. Fujimaru T, Mori T, Sekine A, Mandai S, Chiga M, Kikuchi H, Ando F, Mori Y, Nomura N, Iimori S, Naito S, Okado T, Rai T, Hoshino J, Ubara Y, Uchida S, Sohara E: Kidney enlargement and multiple liver cyst formation implicate mutations in PKD1/2 in adult sporadic polycystic kidney disease Clin Genet. 2018.07; 94 (1): 125-131. ( DOI )

  6. Mandai S, Mori T, Nomura N, Furusho T, Arai Y, Kikuchi H, Sasaki E, Sohara E, Rai T, Uchida S.: WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO4. Scientific Reports. 2018.06; 8 (1): 9101. ( PubMed , DOI )

  7. Sayaka Yoshida, Yuya Araki, Takayasu Mori, Emi Sasaki, Yuri Kasagi, Kiyoshi Isobe, Koichiro Susa, Yuichi Inoue, Pascale Bomont, Tomokazu Okado, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara: Decreased KLHL3 expression is involved in the pathogenesis of pseudohypoaldosteronism type II caused by cullin 3 mutation in vivo. Clin. Exp. Nephrol.. 2018.06; 22 (6): 1251-1257. ( PubMed , DOI )

  8. Satoko Miyamoto, Atsushi Ohkubo, Hiroshi Seshima, Hiroko Yamamoto, Ayako Itagaki, Takuma Maeda, Naoki Kurashima, Takayasu Mori, Soichiro Iimori, Shotaro Naito, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida, Tomokazu Okado: Removal Dynamics of Autoantibodies, Immunoglobulins, and Coagulation Factors by Selective Plasma Exchange on Three Consecutive Days. Ther Apher Dial. 2018.06; 22 (3): 255-260. ( PubMed , DOI )

  9. Lemos DR, McMurdo M, Karaca G, Wilflingseder J, Leaf IA, Gupta N, Miyoshi T, Susa K, Johnson BG, Soliman K, Wang G, Morizane R, Bonventre JV, Duffield JS: Interleukin-1β Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis. Journal of the American Society of Nephrology : JASN. 2018.06; 29 (6): 1690-1705. ( PubMed , DOI )

  10. Naoya Toriu, Hiroki Mizuno, Naoki Sawa, Keiichi Sumida, Tatsuya Suwabe, Noriko Hayami, Akinari Sekine, Masayuki Yamanouchi, Junichi Hoshino, Kenmei Takaichi, Motoko Yanagita, Takuya Fujimaru, Takayasu Mori, Eisei Sohara, Shinichi Uchida, Yoshifumi Ubara: Everolimus Reduces the Size of Tuberous Sclerosis Complex-Related Huge Renal Angiomyolipomas Exceeding 20 cm in the Longest Diameter. Case Rep Oncol. 2018.05; 11 (2): 258-267. ( PubMed , DOI )

  11. Gupta N, Susa K, Yoda Y, Bonventre JV, Valerius MT, Morizane R: CRISPR/Cas9-based Targeted Genome Editing for the Development of Monogenic Diseases Models with Human Pluripotent Stem Cells. Current protocols in stem cell biology. 2018.05; 45 (1): e50. ( PubMed , DOI )

  12. Ando F, Mori S, Yui N, Morimoto T, Nomura N, Sohara E, Rai T, Sasaki S, Kondo Y, Kagechika H, Uchida S.: AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus Nature Communications. 2018.04; 9 (1): 1411.

  13. Ando F, Mori S, Yui N, Morimoto T, Nomura N, Sohara E, Rai T, Sasaki S, Kondo Y, Kagechika H, Uchida S: AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus Nat Commun. 2018.04; 9 (1): 1411. ( PubMed , DOI )

  14. Yohei Arai, Eiichiro Kanda, Soichiro Iimori, Shotaro Naito, Yumi Noda, Sei Sasaki, Eisei Sohara, Tomokazu Okado, Tatemitsu Rai, Shinichi Uchida: Low white blood cell count is independently associated with chronic kidney disease progression in the elderly: the CKD-ROUTE study. Clinical and Experimental Nephrology. 2018.04; 22 (2): 291-298. ( PubMed , DOI )

  15. Toshiyuki Makino, Yoshitatsu Ohara, Namiko Kobayashi, Yohei Kono, Ayumu Nomizu, Mariko Ichijo, Yutaro Mori, Noriaki Matsui, Dai Kishida, Takayuki Toda: Atypical familial Mediterranean fever developed in a long-term hemodialysis patient. Hemodial Int. 2018.04; 22 (2): E19-E22. ( PubMed , DOI )

  16. Takada Daisuke, Sekine Akinari, Yabuuchi Junko, Kogure Yuta, Ueno Toshiharu, Yamanouchi Masayuki, Sumida Keiichi, Suwabe Tatsuya, Hayami Noriko, Hoshino Junichi, Takaichi Kenmei, Kinowaki Keiichi, Fujii Takeshi, Ohashi Kenichi, Mori Takayasu, Sohara Eisei, Uchida Shinichi, Ubara Yoshifumi: Renal histology and MRI in a 25-year-old Japanese man with nephronophthisis 4. Clin Nephrol. 2018.03; 89 (3): 223-228. ( PubMed , DOI )

  17. Hashimoto Hiroko, Nomura Naohiro, Shoda Wakana, Isobe Kiyoshi, Kikuchi Hiroaki, Yamamoto Kouhei, Fujimaru Takuya, Ando Fumiaki, Mori Takayasu, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi, Sohara Eisei: Metformin increases urinary sodium excretion by reducing phosphorylation of the sodium- chloride cotransporter. Metabolism. 2018.03; 85 23-31. ( PubMed , DOI )

  18. Wang Y,Nomura N,Zeniya M,Mori Y,Takahashi D,Naito S,Rai T,Uchida S,Sohara E: High potassium concentration regulates the WNK3–SPAK–NKCC1 phosphorylation cascade via kelch-like protein 2 in mouse vascular smooth muscle cells Journal of Medical and Dental Sciences. 2018.03; 65 (1): 35-44. ( DOI )

  19. Mandai S, Sato H, Iimori S, Naito S, Mori T, Takahashi D, Zeniya M, Nomura N, Sohara E, Okado T, Uchida S, Fushimi K, Rai T.: Dialysis Case Volume Associated With In-Hospital Mortality in Maintenance Dialysis Patients. Kidney International Reports. 2018.03; 3 (2): 356-363. ( PubMed , DOI )

  20. Soichiro Iimori, Shotaro Naito, Yumi Noda, Hidehiko Sato, Naohiro Nomura, Eisei Sohara, Tomokazu Okado, Sei Sasaki, Shinichi Uchida, Tatemitsu Rai: Prognosis of chronic kidney disease with normal-range proteinuria: The CKD-ROUTE study. PLoS ONE. 2018.01; 13 (1): e0190493. ( PubMed , DOI )

  1. Gupta N, Susa K, Morizane R: Regenerative Medicine, Disease Modeling, and Drug Discovery in Human Pluripotent Stem Cell-derived Kidney Tissue. European Medical Journal. Reproductive health. 2017.08; 3 (1): 57-67. ( PubMed )

  2. Miyamoto Satoko, Ohkubo Atsushi, Seshima Hiroshi, Komori Shigeto, Yamamoto Motoki, Maeda Takuma, Itagaki Ayako, Yamamoto Hiroko, Nojima Kohei, Iimori Soichiro, Naito Shotaro, Kurashima Naoki, Sohara Eisei, Rai Tatemitsu, Uchida Shinichi, Okado Tomokazu: 尋常性天疱瘡における選択的血漿交換法による抗デスモグレイン自己抗体、フィブリノゲン、凝固第XIII因子の除去(Selective Plasma Exchange for the Removal of Pemphigus Autoantibodies, Fibrinogen, and Factor XIII in Pemphigus Vulgaris) Therapeutic Apheresis and Dialysis. 2017.06; 21 (3): 226-231. ( ichushi )

  3. Ohkubo Atsushi, Okado Tomokazu, Miyamoto Satoko, Hashimoto Yurie, Komori Shigeto, Yamamoto Motoki, Maeda Takuma, Itagaki Ayako, Yamamoto Hiroko, Seshima Hiroshi, Kurashima Naoki, Iimori Soichiro, Naito Shotaro, Sohara Eisei, Uchida Shinichi, Rai Tatemitsu: 選択的血漿交換におけるフィブリノゲンの減少は膜ファウリングに起因する(Fibrinogen Reduction During Selective Plasma Exchange due to Membrane Fouling) Therapeutic Apheresis and Dialysis. 2017.06; 21 (3): 232-237. ( ichushi )

  4. Arai Yohei, Kanda Eiichiro, Iimori Soichiro, Naito Shotaro, Noda Yumi, Kawasaki Tomoki, Sato Hidehiko, Ando Ryoichi, Sasaki Sei, Sohara Eisei, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi: ステージ4・5慢性腎臓病に対するビタミンD類似体の使用は好ましい腎予後と独立して関連する　CKD-ROUTE研究(The use of vitamin D analogs is independently associated with the favorable renal prognosis in chronic kidney disease stages 4-5: the CKD-ROUTE study) Clinical and Experimental Nephrology. 2017.06; 21 (3): 481-487. ( ichushi )

  5. Ito Sakuya, Taguchi Kensei, Nakayama Yosuke, Kaida Yusuke, Sohara Eisei, Uchida Shinichi, Fukami Kei: INCREASED SODIUM CHLORIDE COTRANSPORTER EXPRESSION IN A RAT REMNANT KIDNEY MODEL NEPHROLOGY DIALYSIS TRANSPLANTATION. 2017.05; 32

  6. Sasaki E, Susa K, Mori T, Isobe K, Araki Y, Inoue Y, Yoshizaki Y, Ando F, Mori Y, Mandai S, Zeniya M, Takahashi D, Nomura N, Rai T, Uchida S, Sohara E: KLHL3 knockout mice reveal the physiological role of KLHL3 and the pathophysiology of pseudohypoaldosteronism type II caused by mutant KLHL3. Mol Cell Biol. 2017.04; 37 (7): ( PubMed , DOI )

  7. Takahashi D, Mori T, Sohara E, Tanaka M, Chiga M, Inoue Y, Nomura N, Zeniya M, Ochi H, Takeda S, Suganami T, Rai T, Uchida S: WNK4 is an adipogenic factor and its deletion reduces diet-induced obesity in mice. EBioMedicine. 2017.04; 18 118-127. ( PubMed , DOI )

  8. Mandai S, Furukawa S, Kodaka M, Hata Y, Mori T, Nomura N, Ando F, Mori Y, Takahashi D, Yoshizaki Y, Kasagi Y, Arai Y, Sasaki E, Yoshida S, Furuichi Y, Fujii NL, Sohara E, Rai T, Uchida S.: Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy. Scientific Reports. 2017.04; 7 46369. ( PubMed , DOI )

  9. Sinha Adya Saran, Hosoi Yasushi, Sohara Eisei, Mutoh Hiroki, Akita Tenpei, Uchida Shinichi, Fukuda Atsuo: 前頭前野の第V層錐体神経細胞におけるWNK3の興奮に関する役割(Excitatory roles of WNK3 in layer V pyramidal neurons in the prefrontal cortex) The Journal of Physiological Sciences. 2017.03; 67 (Suppl.1): S116. ( ichushi )

  10. Shoda W, Nomura N, Ando F, Mori Y, Mori T, Sohara E, Rai T, Uchida S: Calcineurin inhibitors block sodium-chloride cotransporter dephosphorylation in response to high potassium intake. Kidney Int. 2017.02; 91 (2): 402-411. ( PubMed , DOI )

  11. Mandai S, Kanda E, Iimori S, Naito S, Noda Y, Kikuchi H, Akazawa M, Oi K, Toda T, Sohara E, Okado T, Sasaki S, Rai T, Uchida S.: Association of serum chloride level with mortality and cardiovascular events in chronic kidney disease: the CKD-ROUTE study. Clin. Exp. Nephrol.. 2017.02; 21 (1): 104-111. ( PubMed , DOI )

  12. Kikuchi Hiroaki, Kanda Eiichiro, Mandai Shintaro, Akazawa Masanobu, Iimori Soichiro, Oi Katsuyuki, Naito Shotaro, Noda Yumi, Toda Takayuki, Tamura Teiichi, Sasaki Sei, Sohara Eisei, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi: 低いBMIと血清アルブミン値の組み合わせは慢性腎疾患進行と関連する　chronic kidney-research of outcomes in treatment and epidemiology(CKD-ROUTE)研究(Combination of low body mass index and serum albumin level is associated with chronic kidney disease progression: the chronic kidney disease-research of outcomes in treatment and epidemiology(CKD-ROUTE) study) Clinical and Experimental Nephrology. 2017.02; 21 (1): 55-62. ( ichushi )

  13. Mandai Shintaro, Kanda Eiichiro, Iimori Soichiro, Naito Shotaro, Noda Yumi, Kikuchi Hiroaki, Akazawa Masanobu, Oi Katsuyuki, Toda Takayuki, Sohara Eisei, Okado Tomokazu, Sasaki Sei, Rai Tatemitsu, Uchida Shinichi: 慢性腎疾患における血清塩化物濃度と死亡率および心血管イベントとの関連　CKD-ROUTE研究(Association of serum chloride level with mortality and cardiovascular events in chronic kidney disease: the CKD-ROUTE study) Clinical and Experimental Nephrology. 2017.02; 21 (1): 104-111. ( ichushi )

  14. Mori Takayasu, Hosomichi Kazuyoshi, Chiga Motoko, Mandai Shintaro, Nakaoka Hirofumi, Sohara Eisei, Okado Tomokazu, Rai Tatemitsu, Sasaki Sei, Inoue Ituro, Uchida Shinichi: カスタムパネルによる次世代シーケンシングを用いた主要な遺伝性腎疾患に対する包括的遺伝子検査手法(Comprehensive genetic testing approach for major inherited kidney diseases, using next-generation sequencing with a custom panel) Clinical and Experimental Nephrology. 2017.02; 21 (1): 63-75. ( ichushi )

  1. Ando F, Sohara E, Morimoto T, Yui N, Nomura N, Kikuchi E, Takahashi D, Mori T, Vandewalle A, Rai T, Sasaki S, Kondo Y, Uchida S: Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway. Nat Commun. 2016.11; 7 13636. ( PubMed , DOI )

  1. Mandai S, Mori T, Sohara E, Rai T, Uchida S: Generation of hypertension-associated STK39 polymorphism knockin cell lines with the clustered regularly interspaced short palindromic repeats/Cas9 system. Hypertension. 2015.12; 66 (6): 1199-1206. ( PubMed , DOI )

  2. Zeniya M, Morimoto N, Takahashi D, Mori Y, Mori T, Ando F, Araki Y, Yoshizaki Y, Inoue Y, Isobe K, Nomura N, Oi K, Nishida H, Sasaki S, Sohara E, Rai T, Uchida S: Kelch-Like Protein 2 mediates angiotensin II-With No Lysine 3 signaling in the regulation of vascular tonus. J Am Soc Nephrol. 2015.09; 26 (9): 2129-2138. ( PubMed , DOI )

  3. Kuwahara M, Mandai S, Kasagi Y, Kusaka K, Tanaka T, Shikuma S, Akita W.: Responsiveness to erythropoiesis-stimulating agents and renal survival in patients with chronic kidney disease. Clin Exp Nephrol. 2015.08; 19 (4): 598-605. ( PubMed , DOI )

  4. Kikuchi E, Mori T, Zeniya M, Isobe K, Ishigami-Yuasa M, Fujii S, Kagechika H, Ishihara T, Mizushima T, Sasaki S, Sohara E, Rai T, Uchida S: Discovery of novel SPAK inhibitors that block WNK kinase signaling to cation chloride transporters. J Am Soc Nephrol. 2015.07; 26 (7): 1525-1536. ( PubMed , DOI )

  1. Inoue Y, Sohara E, Kobayashi K, Chiga M, Rai T, Ishibashi K, Horie S, Su X, Zhou J, Sasaki S, Uchida S: Aberrant glycosylation and localization of polycystin-1 cause polycystic kidney in an AQP11 knockout model. J Am Soc Nephrol. 2014.12; 25 (12): 2789-2799. ( PubMed , DOI )

  2. Mandai S*, Kasagi Y, Kusaka K, Shikuma S, Akita W, Kuwahara M.: Helicobacter cinaedi kidney cyst infection and bacteremia in a patient with autosomal dominant polycystic kidney disease J Infect Chemother. 2014.11; 20 (11): 732-734. ( PubMed , DOI )

  3. Kuwahara M, Hasumi S, Mandai S, Tanaka T, Shikuma S, Akita W, Mori Y, Sasaki S.: Effects of three kinds of erythropoiesis-stimulating agents on renal anemia in Japanese non-dialysis chronic kidney disease patients. Clin Exp Nephrol. 2014.10; 18 (5): 755-762. ( PubMed , DOI )

  4. Susa K, Sohara E, Rai T, Zeniya M, Mori Y, Mori T, Chiga M, Nomura N, Nishida H, Takahashi D, Isobe K, Inoue Y, Takeishi K, Takeda N, Sasaki S, Uchida S: Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice. Hum Mol Genet. 2014.10; 23 (19): 5052-5060. ( PubMed , DOI )

  5. Kuwahara M, Hasumi S, Mandai S, Tanaka T, Shikuma S, Akita W, Mori Y, Sasaki S.: Rate of ankle-brachial index decline predicts cardiovascular mortality in hemodialysis patients. Ther Apher Dial. 2014.02; 18 (1): 9-18. ( PubMed , DOI )

  1. Mandai S*, Kuwahara M, Kasagi Y, Kusaka K, Tanaka T, Shikuma S, Akita W, Sasaki S.: Lower serum sodium level predicts higher risk of infection-related hospitalization in maintenance hemodialysis patients: an observational cohort study BMC Nephrol. 2013.12; 14 276. ( PubMed , DOI )

  2. Mori Takayasu, Kikuchi Eriko, Watanabe Yuko, Fujii Shinya, Ishigami-Yuasa Mari, Kagechika Hiroyuki, Sohara Eisei, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi: Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy. Biochem J. 2013.11; 455 (3): 339-345. ( PubMed , DOI )

  3. Isobe Kiyoshi, Mori Takayasu, Asano Takako, Kawaguchi Hiroyuki, Nonoyama Shigeaki, Kumagai Naonori, Kamada Fumiaki, Morimoto Tetsuji, Hayashi Matsuhiko, Sohara Eisei, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi: Development of enzyme-linked immunosorbent assays for urinary thiazide-sensitive Na-Cl cotransporter measurement. Am J Physiol Renal Physiol. 2013.11; 305 (9): F1374-F1381. ( PubMed , DOI )

  4. Zeniya Moko, Sohara Eisei, Kita Satomi, Iwamoto Takahiro, Susa Koichiro, Mori Takayasu, Oi Katsuyuki, Chiga Motoko, Takahashi Daiei, Yang Sung-Sen, Lin Shih-Hua, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi: Dietary salt intake regulates WNK3-SPAK-NKCC1 phosphorylation cascade in mouse aorta through angiotensin II. Hypertension. 2013.11; 62 (5): 872-878. ( PubMed , DOI )

  5. Nomura Naohiro, Kamiya Kazusaku, Ikeda Katsuhisa, Yui Naofumi, Chiga Motoko, Sohara Eisei, Rai Tatemitu, Sakaki Sei, Uchida Shinich: Treatment with 17-allylamino-17-demethoxygeldanamycin ameliorated symptoms of Bartter syndrome type IV caused by mutated Bsnd in mice. Biochem Biophys Res Commun. 2013.11; 441 (3): 544-549. ( PubMed , DOI )

  6. Ando Fumiaki, Okado Tomokazu, Sohara Eisei, Rai Tatemitsu, Uchida Shinichi, Sasaki Sei: Development of minimal-change glomerular disease and Hashimoto's thyroiditis during the treatment of sarcoidosis. CEN Case Rep. 2013.11; 2 (2): 248-251. ( PubMed , DOI )

  7. Ishimoto Ikue, Sohara Eisei, Ito Eisaku, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi: Fibronectin glomerulopathy. Clin Kidney J. 2013.10; 6 (5): 513-515. ( PubMed , DOI )

  8. Mori Yutaro, Wakabayashi Mai, Mori Takayasu, Araki Yuya, Sohara Eisei, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi: Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms. Biochem Biophys Res Commun. 2013.09; 439 (1): 30-34. ( PubMed , DOI )

  9. Takahashi Daiei, Mori Takayasu, Wakabayashi Mai, Mori Yutaro, Susa Koichiro, Zeniya Moko, Sohara Eisei, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi: KLHL2 interacts with and ubiquitinates WNK kinases. Biochem Biophys Res Commun. 2013.08; 437 (3): 457-462. ( PubMed , DOI )

  10. Mandai S*, Aoyagi M, Nagahama K, Arai Y, Hirasawa S, Aki S, Inaba N, Tanaka H, Tsuura Y, Tamura T, Sasaki S.: Post-staphylococcal infection Henoch-Schönlein purpura nephritis: a case report and review of the literature Ren Fail. 2013.07; 35 (6): 869-874. ( PubMed , DOI )

  11. Ando Fumiaki, Sohara Eisei, Ito Eisaku, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi, Sasaki Sei: Acute poststreptococcal glomerulonephritis with acute interstitial nephritis related to streptococcal pyrogenic exotoxin B. Clin Kidney J. 2013.06; 6 (3): 347-348. ( PubMed , DOI )

  12. Mandai S*, Kanda E, Arai Y, Hirasawa S, Hirai T, Aki S, Inaba N, Aoyagi M, Tanaka H, Ikeda T, Tamura T, Sasaki S.: Anti-centromere antibody is an independent risk factor for chronic kidney disease in patients with primary biliary cirrhosis Clin Exp Nephrol. 2013.06; 17 (3): 405-410. ( PubMed , DOI )

  13. Inoue Risako, Sohara Eisei, Rai Tatemitsu, Satoh Takahiro, Yokozeki Hiroo, Sasaki Sei, Uchida Shinichi: Immunolocalization and translocation of aquaporin-5 water channel in sweat glands. J Dermatol Sci. 2013.04; 70 (1): 26-33. ( PubMed , DOI )

  14. Wakabayashi Mai, Mori Takayasu, Isobe Kiyoshi, Sohara Eisei, Susa Koichiro, Araki Yuya, Chiga Motoko, Kikuchi Eriko, Nomura Naohiro, Mori Yutaro, Matsuo Hiroshi, Murata Tomohiro, Nomura Shinsuke, Asano Takako, Kawaguchi Hiroyuki, Nonoyama Shigeaki, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi: Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension. Cell Rep. 2013.03; 3 (3): 858-868. ( PubMed , DOI )

  1. Susa Koichiro, Sohara Eisei, Isobe Kiyoshi, Chiga Motoko, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi: WNK-OSR1/SPAK-NCC signal cascade has circadian rhythm dependent on aldosterone. Biochem Biophys Res Commun. 2012.11; 427 (4): 743-747. ( PubMed , DOI )

  2. Nishida Hidenori, Sohara Eisei, Nomura Naohiro, Chiga Motoko, Alessi Dario R, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi: Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice. Hypertension. 2012.10; 60 (4): 981-990. ( PubMed , DOI )

  3. Uchida Shinichi, Chiga Motoko, Sohara Eisei, Rai Tatemitsu, Sasaki Sei: Does a beta2-adrenergic receptor-WNK4-Na-Cl co-transporter signal cascade exist in the in vivo kidney? Nat Med. 2012.09; 18 (9): 1324-5; author reply 1325. ( PubMed , DOI )

  4. Susa Koichiro, Kita Satomi, Iwamoto Takahiro, Yang Sung-Sen, Lin Shih-Hua, Ohta Akihito, Sohara Eisei, Rai Tatemitsu, Sasaki Sei, Alessi Dario R, Uchida Shinichi: Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels. Clin Exp Nephrol. 2012.08; 16 (4): 530-538. ( PubMed , DOI )

  5. Hossain Khan Muhammad Zakir, Sohara Eisei, Ohta Akihito, Chiga Motoko, Inoue Yuichi, Isobe Kiyoshi, Wakabayashi Mai, Oi Katsuyuki, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi: Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination. Biochem Biophys Res Commun. 2012.08; 425 (2): 456-461. ( PubMed , DOI )

  6. Mandai S*, Arai Y, Hirasawa S, Hirai T, Aki S, Inaba N, Aoyagi M, Tanaka H, Tamura T, Sasaki S.: Anti-centromere antibody-positive subjects presenting with hypertensive emergency and renal dysfunction in the absence of skin manifestations: a variant of systemic sclerosis or a novel entity? Intern Med. 2012.06; 51 (12): 1567-1572. ( PubMed )

  7. Ohta Eriko, Akazawa Masanobu, Noda Yumi, Mandai Shintaro, Naito Shotaro, Ohta Akihito, Sohara Eisei, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi, Sasaki Sei: Severe hyperparathyroidism in a pre-dialysis chronic kidney disease patient treated with a very low protein diet. J Bone Miner Metab. 2012.03; 30 (2): 238-242. ( PubMed , DOI )

  8. Oi Katsuyuki, Sohara Eisei, Rai Tatemitsu, Misawa Moko, Chiga Motoko, Alessi Dario R, Sasaki Sei, Uchida Shinichi: A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo. Biol Open. 2012.02; 1 (2): 120-127. ( PubMed , DOI )

  9. Hara-Chikuma Mariko, Sugiyama Yoshinori, Kabashima Kenji, Sohara Eisei, Uchida Shinichi, Sasaki Sei, Inoue Shintaro, Miyachi Yoshiki: Involvement of aquaporin-7 in the cutaneous primary immune response through modulation of antigen uptake and migration in dendritic cells. FASEB J. 2012.01; 26 (1): 211-218. ( PubMed , DOI )

  1. Lin Shih-Hua, Yu I-Shing, Jiang Si-Tse, Lin Shu-Wha, Chu Pauling, Chen Ann, Sytwu Huey-Kang, Sohara Eisei, Uchida Shinichi, Sasaki Sei, Yang Sung-Sen: Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome. Proc Natl Acad Sci U S A. 2011.10; 108 (42): 17538-17543. ( PubMed , DOI )

  2. Sohara Eisei, Rai Tatemitsu, Yang Sung-Sen, Ohta Akihito, Naito Shotaro, Chiga Motoko, Nomura Naohiro, Lin Shih-Hua, Vandewalle Alain, Ohta Eriko, Sasaki Sei, Uchida Shinichi: Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney. PLoS One. 2011.08; 6 (8): e24277. ( PubMed , DOI )

  3. Nomura Naohiro, Tajima Masato, Sugawara Noriko, Morimoto Tetsuji, Kondo Yoshiaki, Ohno Mayuko, Uchida Keiko, Mutig Kerim, Bachmann Sebastian, Soleimani Manoocher, Ohta Eriko, Ohta Akihito, Sohara Eisei, Okado Tomokazu, Rai Tatemitsu, Jentsch Thomas J, Sasaki Sei, Uchida Shinichi: Generation and analyses of R8L barttin knockin mouse. Am J Physiol Renal Physiol. 2011.08; 301 (2): F297-F307. ( PubMed , DOI )

  4. Mandai S*, Nagahama K, Tsuura Y, Hirai T, Yoshioka W, Takahashi D, Aki S, Aoyagi M, Tanaka H, Tamura T.: Recovery of renal function in a dialysis-dependent patient with microscopic polyangiitis and both myeloperoxidase anti-neutrophil cytoplasmic antibodies and anti-glomerular basement membrane antibodies Intern Med. 2011.08; 50 (15): 1599-1603. ( PubMed )

  5. Chiga Motoko, Rafiqi Fatema H, Alessi Dario R, Sohara Eisei, Ohta Akihito, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi: Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade. J Cell Sci. 2011.05; 124 (Pt 9): 1391-1395. ( PubMed , DOI )

  6. Naito Shotaro, Ohta Akihito, Sohara Eisei, Ohta Eriko, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi: Regulation of WNK1 kinase by extracellular potassium. Clin Exp Nephrol. 2011.04; 15 (2): 195-202. ( PubMed , DOI )

  1. Talati Gulibaha, Ohta Akihito, Rai Tatemitsu, Sohara Eisei, Naito Shotaro, Vandewalle Alain, Sasaki Sei, Uchida Shinichi: Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney. Biochem Biophys Res Commun. 2010.03; 393 (4): 844-848. ( PubMed , DOI )

  2. Noda Yumi, Sohara Eisei, Ohta Eriko, Sasaki Sei: Aquaporins in kidney pathophysiology. Nat Rev Nephrol. 2010.03; 6 (3): 168-178. ( PubMed , DOI )

  1. Ohta Eriko, Itoh Tomohiro, Nemoto Tomomi, Kumagai Jiro, Ko Shigeru B H, Ishibashi Kenichi, Ohno Mayuko, Uchida Keiko, Ohta Akihito, Sohara Eisei, Uchida Shinichi, Sasaki Sei, Rai Tatemitsu: Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis. Am J Physiol Cell Physiol. 2009.12; 297 (6): C1368-C1378. ( PubMed , DOI )

  2. Yui Naofumi, Okutsu Rie, Sohara Eisei, Rai Tatemitsu, Ohta Akihito, Noda Yumi, Sasaki Sei, Uchida Shinichi: FAPP2 is required for aquaporin-2 apical sorting at trans-Golgi network in polarized MDCK cells. Am J Physiol Cell Physiol. 2009.12; 297 (6): C1389-C1396. ( PubMed , DOI )

  3. Ohta Akihito, Rai Tatemitsu, Yui Naofumi, Chiga Motoko, Yang Sung-Sen, Lin Shih-Hua, Sohara Eisei, Sasaki Sei, Uchida Shinichi: Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. Hum Mol Genet. 2009.10; 18 (20): 3978-3986. ( PubMed , DOI )

  4. Sohara Eisei, Uchida Shinichi, Sasaki Sei: Function of aquaporin-7 in the kidney and the male reproductive system. Handb Exp Pharmacol. 2009.01; (190): 219-231. ( PubMed , DOI )

  1. Sohara Eisei, Luo Ying, Zhang Jingjing, Manning Danielle K, Beier David R, Zhou Jing: Nek8 regulates the expression and localization of polycystin-1 and polycystin-2. J Am Soc Nephrol. 2008.03; 19 (3): 469-476. ( PubMed , DOI )

  1. Yang Sung-Sen, Morimoto Tetsuji, Rai Tatemitsu, Chiga Motoko, Sohara Eisei, Ohno Mayuko, Uchida Keiko, Lin Shih-Hua, Moriguchi Tetsuo, Shibuya Hiroshi, Kondo Yoshiaki, Sasaki Sei, Uchida Shinichi: Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab. 2007.05; 5 (5): 331-344. ( PubMed , DOI )

  2. Sohara Eisei, Ueda Otoya, Tachibe Takanori, Hani Toshio, Jishage Kou-ichi, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi: Morphologic and functional analysis of sperm and testes in Aquaporin 7 knockout mice. Fertil Steril. 2007.03; 87 (3): 671-676. ( PubMed , DOI )

  3. Yakata Kaya, Hiroaki Yoko, Ishibashi Kenichi, Sohara Eisei, Sasaki Sei, Mitsuoka Kaoru, Fujiyoshi Yoshinori: Aquaporin-11 containing a divergent NPA motif has normal water channel activity. Biochim Biophys Acta. 2007.03; 1768 (3): 688-693. ( PubMed , DOI )

  1. Sohara Eisei, Rai Tatemitsu, Yang Sung-Sen, Uchida Keiko, Nitta Kosaku, Horita Shigeru, Ohno Mayuko, Harada Akihiro, Sasaki Sei, Uchida Shinichi: Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation. Proc Natl Acad Sci U S A. 2006.09; 103 (38): 14217-14222. ( PubMed , DOI )

  2. Sohara Eisei, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi: Physiological roles of AQP7 in the kidney: Lessons from AQP7 knockout mice. Biochim Biophys Acta. 2006.08; 1758 (8): 1106-1110. ( PubMed , DOI )

  3. Suda Shin, Rai Tatemitsu, Sohara Eisei, Sasaki Sei, Uchida Shinichi: Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter. Biochem Biophys Res Commun. 2006.05; 344 (1): 246-252. ( PubMed , DOI )

  4. Suzuki Tatsunori, Rai Tatemitsu, Hayama Atsushi, Sohara Eisei, Suda Shin, Itoh Tomohiro, Sasaki Sei, Uchida Shinichi: Intracellular localization of ClC chloride channels and their ability to form hetero-oligomers. J Cell Physiol. 2006.03; 206 (3): 792-798. ( PubMed , DOI )

  1. Sohara Eisei, Rai Tatemitsu, Miyazaki Jun-ichi, Verkman A S, Sasaki Sei, Uchida Shinichi: Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice. Am J Physiol Renal Physiol. 2005.12; 289 (6): F1195-F1200. ( PubMed , DOI )

  2. Uchida Shinichi, Sohara Eisei, Rai Tatemitsu, Ikawa Masahito, Okabe Masaru, Sasaki Sei: Impaired urea accumulation in the inner medulla of mice lacking the urea transporter UT-A2. Mol Cell Biol. 2005.08; 25 (16): 7357-7363. ( PubMed , DOI )

  3. Yamauchi Kozue, Yang Sung-Sen, Ohta Akihito, Sohara Eisei, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi: Apical localization of renal K channel was not altered in mutant WNK4 transgenic mice. Biochem Biophys Res Commun. 2005.07; 332 (3): 750-755. ( PubMed , DOI )

  4. Yang Sung-Sen, Yamauchi Kozue, Rai Tatemitsu, Hiyama Atsushi, Sohara Eisei, Suzuki Tatsunori, Itoh Tomohiro, Suda Shin, Sasaki Sei, Uchida Shinichi: Regulation of apical localization of the thiazide-sensitive NaCl cotransporter by WNK4 in polarized epithelial cells. Biochem Biophys Res Commun. 2005.05; 330 (2): 410-414. ( PubMed , DOI )

  5. Hara-Chikuma Mariko, Sohara Eisei, Rai Tatemitsu, Ikawa Masahito, Okabe Masaru, Sasaki Sei, Uchida Shinichi, Verkman A S: Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation. J Biol Chem. 2005.04; 280 (16): 15493-15496. ( PubMed , DOI )

  1. Yamauchi Kozue, Rai Tatemitsu, Kobayashi Katsuki, Sohara Eisei, Suzuki Tatsunori, Itoh Tomohiro, Suda Shin, Hayama Atsushi, Sasaki Sei, Uchida Shinichi: Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins. Proc Natl Acad Sci U S A. 2004.03; 101 (13): 4690-4694. ( PubMed , DOI )

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  1. Makiko Mori, Yutaro Mori, Corby Fink, Takaharu Ichimura, Keisuke Sako, Yuki Nakao, Astrid Weins, Shinichi Uchida, Joseph V. Bonven: Kidney Injury Molecule-1 Is an Independent Receptor from ACE2 for SARS-CoV-2 in Lung and Kidney Journal of the American Society of Nephrology. 2023.10; 34 (Abstract Supplementment): 715.

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