Department of Gastroenterology and Hepatology

516  articles.  
* There may be some overlapped articles listed due to the difference of format.

  1. Keitaro Shibuya, Akiko Tamura, Daiki Yafuso, Ami Kawamoto, Shuji Hibiya, Kento Takenaka, Hiromichi Shimizu, Toshimitsu Fujii, Kazuo Ohtsuka, Ryuichi Okamoto: Case Report of a Rapidly Progressive Indolent T-Cell Lymphoma of the Gastrointestinal Tract. DEN Open. 2027.04; 7 e70340. ( PubMed , DOI )

  1. Kento Inada, Masato Miyoshi, Sei Kakinuma, Keiya Watakabe, Tomohiro Mochida, Taro Shimizu, Jun Tsuchiya, Tsubasa Nobusawa, Shun Kaneko, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Mina Nakagawa, Yasuhiro Asahina, Ryuichi Okamoto: Matrix stiffness shapes early transcriptional trajectories during hepatic stellate cell activation. Hepatol Int. 2026.09; ( PubMed , DOI )

  2. Ryo Morikawa, Toshimitsu Fujii, Akiko Tamura, Ami Kawamoto, Shuji Hibiya, Kento Takenaka, Hiromichi Shimizu, Kazuo Ohtsuka, Ryuichi Okamoto: Real-world data on the effectiveness of risankizumab as induction therapy for ustekinumab-refractory ulcerative colitis. Intest Res. 2026.08; ( PubMed , DOI )

  3. Ryo Morikawa, Yuka Hachisu, Toshimitsu Fujii, Hiromi Kondo, Akifumi Mochizuki, Risa Onizawa, Iichiroh Onishi, Kazuo Ohtsuka, Ryuichi Okamoto: A case of immune-mediated adverse events enterocolitis and duodenitis with gastrointestinal bleeding successfully treated with ustekinumab. Clin J Gastroenterol. 2026.08; 19 (4): 817-821. ( PubMed , DOI )

  4. Ami Kawamoto, Kento Takenaka, Junichi Tsuchiya, Momo Wakui, Kazuo Ohtsuka, Ryuichi Okamoto: Post-treatment simplified MaRIA score predicts clinical outcome in Crohn's disease patients. Intest Res. 2026.07; ( PubMed , DOI )

  5. Kento Takenaka, Ami Kawamoto, Shuji Hibiya, Akiko Tamura, Ryo Morikawa, Hiromichi Shimizu, Toshimitsu Fujii, Kazuo Ohtsuka, Ryuichi Okamoto: Stricture dynamics and prognosis during biologic therapy in ileal Crohn's disease: a real-world cohort. Inflamm Bowel Dis. 2026.07; 32 (7): 1211-1218. ( PubMed , DOI )

  6. Shohei Kimura, Yutaka Yasui, Nobuharu Tamaki, Mayu Higuchi, Takuya Shima, Mina Taguchi, Yudai Yamazaki, Risa Seike, Naoki Uchihara, Yuki Tanaka, Ryohei Kobayashi, Junko Yagita, Yuka Kasano, Yasuyuki Komiyama, Kenta Takaura, Hitomi Takada, Shohei Tanaka, Chiaki Maeyashiki, Yuka Takahashi, Hiroyuki Nakanishi, Kaoru Tsuchiya, Namiki Izumi, Masayuki Kurosaki: Association Between Early and Long-Term Changes in Liver Stiffness in Patients with MASLD Undergoing Serial Magnetic Resonance Elastography. Diagnostics (Basel). 2026.06; 16 (12): ( PubMed , DOI )

  7. Akiko Tamura, Toshimitsu Fujii, Shun Fujiwara, Chiaki Maeyashiki, Ryo Morikawa, Ami Kawamoto, Shuji Hibiya, Kento Takenaka, Hiromichi Shimizu, Kazuo Ohtsuka, Ryuichi Okamoto: Efficacy and Rapid Response of Ustekinumab for Hospitalized Patients With Severe Ulcerative Colitis. Inflamm Bowel Dis. 2026.05; 32 (5): 1005-1008. ( PubMed , DOI )

  8. Yuki Tanaka, Nobuharu Tamaki, Hiroyuki Nakanishi, Takuya Shima, Mina Taguchi, Yudai Yamazaki, Naoki Uchihara, Risa Seike, Shohei Kimura, Junko Yagita, Ryohei Kobayashi, Yuka Kasano, Yasuyuki Komiyama, Kenta Takaura, Hitomi Takada, Shohei Tanaka, Chiaki Maeyashiki, Yutaka Yasui, Kaoru Tsuchiya, Yuka Takahashi, Namiki Izumi, Masayuki Kurosaki: Serum Zinc Threshold and the Prognostic Impact of Zinc Supplementation in Liver Cirrhosis. Nutrients. 2026.05; 18 (9): ( PubMed , DOI )

  9. Nobuharu Tamaki, Masayuki Kurosaki, Hironori Ochi, Hideki Fujii, Yuichiro Suzuki, Takuya Sho, Hayato Hikita, Hiroyuki Marusawa, Yasuhiro Asahina, Namiki Izumi, Tatsuya Kanto: Retreatment of Direct Acting Agents (DAAs) After Initial DAA Failure in Hepatitis C Patients. Hepatol Res. 2026.05; 56 (5): 778-783. ( PubMed , DOI )

  10. Takanori Suzuki, Kentaro Matsuura, Yuki Tahata, Hayato Hikita, Masaru Enomoto, Atsunori Tsuchiya, Daiki Miki, Hiroshi Yatsuhashi, Hidekatsu Kuroda, Taro Yamashita, Hitoshi Yoshiji, Nobuharu Tamaki, Seiichi Mawatari, Hisamitsu Miyaaki, Yasuhiro Asahina, Yoichi Hiasa, Yoshihito Uchida, Yasunari Nakamoto, Taro Takami, Takahiro Kodama, Tetsuo Takehara: Post-to Pretreatment Ratio of Serum CXCL10 Level Predicts Short-Term Liver Function Outcome in Compensated and Decompensated Cirrhotic Patients Due to Chronic Hepatitis C Virus Infection After Direct-Acting Antiviral Therapy. Hepatol Res. 2026.05; 56 (5): 840-852. ( PubMed , DOI )

  11. Morikawa R, Nitta K, Yasuda S, Kano Y, Noji R, Aoyama S, Sato S, Ikeda S, Okamoto R, Nagata M, Mori T, Suenaga M: Identification of risk factors for gastrointestinal immune-related adverse events associated with immune check point inhibitors. Expert opinion on drug safety. 2026.05; 25 (5): 881-888. ( PubMed , DOI )

  12. Yuichi Fukami, Nagako Nishihira, Kazuki Kawakami, Yuka Hayakawa, Yuki Matsui, Midori Wakiya, Masayoshi Fukuda, Hiromichi Shimizu, Kazuo Ohtsuka, Ryuichi Okamoto: A Case of Gastric Metastasis of Renal Cell Carcinoma Resected by Endoscopic Submucosal Dissection After Endoscopic Follow-up of Morphological Changes. DEN Open. 2026.04; 6 (1): e70257. ( PubMed , DOI )

  13. Takahiro Shin, Hiromune Katsuda, Daisuke Ban, Ryuichi Okamoto: Migrated Cholecystectomy Clip in a Case with Common Bile Duct Stones. Intern Med. 2026.04; ( PubMed , DOI )

  14. 米本有輝、山本くらら、岡本隆一: 【なんじゃこりゃ? part 3】大腸　直腸の黒色腫瘤 消化器内視鏡. 2026.04; 38 (4): 487-488.

  15. Ryo Morikawa, Ryosuke Kanaya, Hiromichi Shimizu, Masayoshi Fukuda, Yasuhiro Nemoto, Toshimitsu Fujii, Towako Taguchi, Kurara Yamamoto, Kazuo Ohtsuka, Ryuichi Okamoto: A Rare Case of Immune-related Adverse Events Localized to the Small Intestine. DEN Open. 2026.04; 6 (1): e70187. ( PubMed , DOI )

  16. Fujii S, Espenschied ST, Anand V, Bettencourt-Silva J, Han Y, Ito G, Koseki A, Kosugi A, Kozloski J, Matsumoto R, Meng S, Mulligan N, Musich RJ, Newhall KP, Oshina E, Sekiguchi S, Wang Y, Hu J, Ciorba M, Sibley LD, Okamoto R, Stappenbeck TS: Quantifying the fidelity of in vitro human cell culture systems using a biomedical foundation model. Proceedings of the National Academy of Sciences of the United States of America. 2026.03; 123 (12): e2520482123. ( PubMed , DOI )

  17. Hady Yuki Sugihara, Sayaka Nagata, Sho Kawasaki, Junichi Takahashi, Yui Hiraguri, Masayoshi Fukuda, Kohei Suzuki, Tatsuro Murano, Satoru Fujii, Toshimitsu Fujii, Hiromichi Shimizu, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto, Tomohiro Mizutani: Peptide-based Wnt signal activation enables scalable production of clinical-grade patient-derived intestinal organoids for regenerative cell therapy. Stem Cell Res Ther. 2026.03; ( PubMed , DOI )

  18. Hiromune Katsuda, Takahiro Shin, Ami Kawamoto, Ryuichi Okamoto: Severe Pancreatic Leakage post-EUS-TA Associated with Pancreatic Divisum. Intern Med. 2026.03; ( PubMed , DOI )

  19. Shohei Suzuki, Kentaro Miyamoto, Anna Tojo, Yusuke Yoshimatsu, Toshiaki Teratani, Hitoshi Uchida, Yasuhiro Nemoto, Ryuichi Okamoto, Andreas Michael Sihombing, Toshiro Sato, Jin Nakahara, Takanori Kanai, Tomohisa Sujino: Intestinal epithelial MHC class II induces encephalitogenic CD4 T cells and initiates central nervous system autoimmunity. Sci Immunol. 2026.03; 11 (117): eaec1627. ( PubMed , DOI )

  20. Tomohiko Taniai, Shu Shimada, Yoshimitsu Akiyama, Megumi Hatano, Koya Yasukawa, Yosuke Igarashi, Shu Tsukihara, Yoshiaki Tanji, Keita Kodera, Kohei Okazaki, Koichiro Haruki, Atsushi Nara, Kohei Yagi, Keiichi Akahoshi, Daisuke Ban, Yasuhiro Asahina, Toru Ikegami, Minoru Tanabe, Shinji Tanaka: Integrative transcriptome profiling elucidates molecular and immunovascular characteristics of macrotrabecular HCC. Hepatology. 2026.02; 83 (2): 231-248. ( PubMed , DOI )

  21. Minori Nishiya, Keito Suzuki, Miyako Murakawa, Shun Kaneko, Tsubasa Nobusawa, Kei Onodera, Yuko Kinowaki, Morito Kurata, Yasuhiro Asahina, Ryuichi Okamoto: Primary epithelioid angiosarcoma of the liver. Clin J Gastroenterol. 2026.02; 19 (1): 84-90. ( PubMed , DOI )

  22. Sakura Kirino, Fumiya Uefune, Kensuke Miyake, Nobuhiko Ogasawara, Sakurako Kobayashi, Satoshi Watanabe, Yui Hiraguri, Go Ito, Keiichi Akahoshi, Daisuke Ban, Johan H van Es, Hans Clevers, Mamoru Watanabe, Ryuichi Okamoto, Shiro Yui: Fetal reversion from diverse lineages sustains the intestinal stem cell pool and confers stress resilience. Commun Biol. 2026.01; ( PubMed , DOI )

  23. Yuta Myojin, Hayato Hikita, Yuki Tahata, Kenji Fukumoto, Seiya Kato, Yoichi Sasaki, Shusuke Kumazaki, Atsunori Tsuchiya, Masaru Enomoto, Daiki Miki, Hiroshi Yatsuhashi, Hidekatsu Kuroda, Yoshihito Uchida, Hitoshi Yoshiji, Taro Yamashita, Seiichi Mawatari, Nobuharu Tamaki, Hisamitsu Miyaaki, Yasuhiro Asahina, Goki Suda, Kentaro Matsuura, Yasunari Nakamoto, Yoichi Hiasa, Taro Takami, Kumiko Shirai, Kazuki Maesaka, Kazuhiro Murai, Yuki Makino, Yoshinobu Saito, Takahiro Kodama, Tomohide Tatsumi, Tetsuo Takehara: Serum Growth Differentiation Factor 15 Can Be a Novel Biomarker to Predict the Prognosis of Patients With Hepatitis C Virus Cirrhosis After Virus Elimination. Hepatol Res. 2026.01; 56 (1): 21-32. ( PubMed , DOI )

  24. Ami Kawamoto, Toshimitsu Fujii, Shohei Tanaka, Sho Watanabe, Shohei Tomii, Kento Takenaka, Shuji Hibiya, Ryo Morikawa, Akiko Tamura, Hiromichi Shimizu, Masayuki Kurosaki, Tsunehito Yauchi, Kazuo Ohtsuka, Ryuichi Okamoto: Leucine-Rich Alpha-2 Glycoprotein Is an Accurate Serum Marker for Endoscopic and Histological Remission in Ulcerative Colitis. Inflamm Intest Dis. 2026; 11 (1): 139-146. ( PubMed , DOI )

  25. Fumihiko Nakamura, Kentaro Ishii, Masahiko Kuroda, Yukako Nemoto: Successful Salvage Underwater Endoscopic Mucosal Resection for Early Colorectal Cancer with Unclear Horizontal and Vertical Margin after Cold Snare Polypectomy: Two Case Reports. J Anus Rectum Colon. 2026; 10 (3): 500-506. ( PubMed , DOI )

  26. Hiromune Katsuda, Go Ito, Franziska Kimmig, Tomohiro Muto, Neha Mishra, Joana Pimenta Bernardes, Yui Hiraguri, Hironari Yamashita, Akira Ito, Yuko Kinowaki, Takahiro Shin, Satoru Fujii, Masato Miyoshi, Masanori Kobayashi, Daisuke Asano, Yoshiya Ishikawa, Hiroki Ueda, Keiichi Akahoshi, Eriko Katsuta, Yoshihito Kano, Shiro Yui, Yasuhiro Nemoto, Atsushi Kudo, Daisuke Ban, Yasuhiro Asahina, Stefan Schreiber, Mamoru Watanabe, Philip Rosenstiel, Ryuichi Okamoto: DOCK10 Regulates Insulin Hypersecretion in Insulinoma and Serves as a Diagnostic and Therapeutic Target. Cell Mol Gastroenterol Hepatol. 2026; 20 (5): 101705. ( PubMed , DOI )

  1. Morikawa R, Fujii T, Tamura A, Kawamoto A, Hibiya S, Takenaka K, Shimizu H, Kano Y, Suenaga M, Hamamoto Y, Ohtsuka K, Okamoto R: Diagnostic Performance of Fecal Biomarkers and Their Correlation with Endoscopic Severity in Immune Checkpoint Inhibitor- Related Colitis. Digestion. 2025.12; 1-14. ( PubMed , DOI )

  2. Masatsugu Ohara, Goki Suda, Risako Kohya, Yutaka Yasui, Kaoru Tsuchiya, Masayuki Kurosaki, Joji Tani, Shinya Maekawa, Nobuyuki Enomoto, Makoto Chuma, Manabu Morimoto, Shun Kaneko, Mina Nakagawa, Yasuhiro Asahina, Atsumasa Komori, Yuki Kugiyama, Masaru Baba, Akihisa Nakamura, Jun Ito, Ren Yamada, Shunichi Hosoda, Yoshiya Yamamoto, Sonoe Yoshida, Takuya Sho, Takashi Sasaki, Tomoka Yoda, Akimitsu Meno, Naohiro Yasuura, Qingjie Fu, Zijian Yang, Osamu Maehara, Shunsuke Ohnishi, Yoshimasa Tokuchi, Takashi Kitagataya, Naoki Kawagishi, Masato Nakai, Koji Ogawa, Naoya Sakamoto: Three-year overall survival in unresectable hepatocellular carcinoma treated with atezolizumab plus bevacizumab. Hepatol Int. 2025.12; 19 (6): 1371-1381. ( PubMed , DOI )

  3. Edward Gane, Ewa Janczewska, Tetsuo Takehara, Wan-Long Chuang, Cheng-Yuan Peng, Maria Hlebowicz, Yasuhiro Asahina, Ting-Tsung Chang, Ronald Kalmeijer, John Jezorwski, Gloria Kim, Zacharias Anastasiou, Thomas N Kakuda, Thierry Verbinnen, Nonko Pehlivanov, Adam Bakala, Oliver Lenz, Michael Biermer: Corrigendum to "Peginterferon-alpha-2a add-on to treatment with siRNA JNJ-73763989 in virologically suppressed chronic hepatitis B: The phase II PENGUIN study" [JHEP Reports 2025 7(10) 101516]. JHEP Rep. 2025.12; 7 (12): 101662. ( PubMed , DOI )

  4. Shohei Kimura, Nobuharu Tamaki, Mayu Higuchi, Takuya Shima, Mina Taguchi, Yudai Yamazaki, Risa Seike, Naoki Uchihara, Yuki Tanaka, Ryohei Kobayashi, Junko Yagita, Yuka Kasano, Yasuyuki Komiyama, Kenta Takaura, Hitomi Takada, Shohei Tanaka, Chiaki Maeyashiki, Yutaka Yasui, Hiroyuki Nakanishi, Kaoru Tsuchiya, Namiki Izumi, Masayuki Kurosaki: Diagnostic Accuracy of FIB-4 Index and FIB-3 Index for Advanced Fibrosis in Chronic Liver Disease and Age-Specific Thresholds. J Clin Med. 2025.11; 14 (23): ( PubMed , DOI )

  5. Takanori Suzuki, Kentaro Matsuura, Yuki Tahata, Hayato Hikita, Ryotaro Sakamori, Norifumi Kawada, Nobuyuki Enomoto, Daiki Miki, Hiroshi Yatsuhashi, Hidekatsu Kuroda, Taro Yamashita, Hitoshi Yoshiji, Masayuki Kurosaki, Seiichi Mawatari, Hisamitsu Miyaaki, Yasuhiro Asahina, Yoichi Hiasa, Satoshi Mochida, Yasunari Nakamoto, Taro Takami, Takahiro Kodama, Tomohide Tatsumi, Tetsuo Takehara: Posttreatment serum CXCL10 level stratifies survival in compensated and decompensated cirrhotic patients due to chronic hepatitis C virus infection after direct-acting antiviral therapy. J Gastroenterol. 2025.10; 60 (10): 1272-1283. ( PubMed , DOI )

  6. Tsubasa Nobusawa, Shun Kaneko, Miyako Murakawa, Jun Tsuchiya, Masato Miyoshi, Fukiko Kawai-Kitahata, Mina Nakagawa, Sei Kakinuma, Yasuhiro Asahina, Ryuichi Okamoto: Immune-related adverse events in patients with low baseline serum IL-6 treated with durvalumab plus tremelimumab for hepatocellular carcinoma: a case series. Clin J Gastroenterol. 2025.10; 18 (5): 899-904. ( PubMed , DOI )

  7. Yasuaki Mohri, Jialiang Nie, Hironobu Morinaga, Tomoki Kato, Takahiro Aoto, Takashi Yamanashi, Daisuke Nanba, Hiroyuki Matsumura, Sakura Kirino, Kouji Kobiyama, Ken J Ishii, Masahiro Hayashi, Tamio Suzuki, Takeshi Namiki, Jun Seita, Emi K Nishimura: Antagonistic stem cell fates under stress govern decisions between hair greying and melanoma. Nat Cell Biol. 2025.10; 27 (10): 1647-1659. ( PubMed , DOI )

  8. Tomohiro Mochida, Masato Miyoshi, Sei Kakinuma, Taro Shimizu, Jun Tsuchiya, Keiya Watakabe, Kento Inada, Shun Kaneko, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Mina Nakagawa, Mamoru Watanabe, Yasuhiro Asahina, Ryuichi Okamoto: Crosstalk via ICAM-1 enhances supportive phenotype of stellate cells and drives hepatocyte proliferation in iPSC-derived hepatic organoids. Stem Cell Reports. 2025.10; 20 (10): 102642. ( PubMed , DOI )

  9. Edward Gane, Ewa Janczewska, Tetsuo Takehara, Wan-Long Chuang, Cheng-Yuan Peng, Maria Hlebowicz, Yasuhiro Asahina, Ting-Tsung Chang, Ronald Kalmeijer, John Jezorwski, Gloria Kim, Zacharias Anastasiou, Thomas N Kakuda, Thierry Verbinnen, Nonko Pehlivanov, Adam Bakala, Oliver Lenz, Michael Biermer: Peginterferon-alpha-2a add-on to treatment with siRNA JNJ-73763989 in virologically suppressed chronic hepatitis B: The phase II PENGUIN study. JHEP Rep. 2025.10; 7 (10): 101516. ( PubMed , DOI )

  10. Yoichi Nibe-Shirakihara, Shinya Honda, Satoko Arakawa, Satoru Torii, Hajime Tajima Sakurai, Hirofumi Yamaguchi, Shigeru Oshima, Ryuichi Okamoto, Michael Lazarou, Hideshi Kawakami, Shigeomi Shimizu: Optineurin is an adaptor protein for ubiquitinated substrates in Golgi membrane-associated degradation. Nature Communications. 2025.10; 16 (1): 8966. ( PubMed , DOI )

  11. Naoki Kawagishi, Goki Suda, Yuki Tahata, Hayato Hikita, Takahiro Kodama, Satoshi Mochida, Nobuyuki Enomoto, Seiichi Mawatari, Hidekatsu Kuroda, Daiki Miki, Masayuki Kurosaki, Yoichi Hiasa, Norifumi Kawada, Taro Yamashita, Hiroshi Yatsuhashi, Hitoshi Yoshiji, Naoya Kato, Taro Takami, Hisamitsu Miyaaki, Kentaro Matsuura, Yasuhiro Asahina, Yoshito Itoh, Ryosuke Tateishi, Yasunari Nakamoto, Eiji Kakazu, Shuji Terai, Masahito Shimizu, Yoshiyuki Ueno, Norio Akuta, Masatsugu Ohara, Naoya Sakamoto, Tetsuo Takehara: Pretreatment serum angiopoietin-2 predicts prognosis and liver functional reserve after successful HCV eradication with sofosbuvir and velpatasvir in patients with HCV-related decompensated cirrhosis. J Gastroenterol. 2025.09; 60 (9): 1145-1156. ( PubMed , DOI )

  12. Shun Kaneko, Yasuhiro Asahina: Editorial: Bridging the Gap Between Evidence and Practice in Hepatitis B Virus-Related Hepatocellular Carcinoma Prevention. Aliment Pharmacol Ther. 2025.09; 62 (6): 664-665. ( PubMed , DOI )

  13. Goki Suda, Masaya Sugiyama, Hayato Hikita, Akira Nishio, Tomohide Tatsumi, Tetsuo Takehara, Miyako Murakawa, Mina Nakagawa, Yasuhiro Asahina, Masashi Mizokami, Tatsuhiko Kakisaka, Yuzuru Sakamoto, Akinobu Taketomi, Koji Miyanishi, Yoshiyuki Ueno, Hiroaki Haga, Shinya Maekawa, Nobuyuki Enomoto, Masayuki Kurosaki, Motoyuki Kohjima, Makoto Nakamuta, Yasuhito Tanaka, Yoshiya Yamamoto, Masaru Baba, Hisatoshi Hanamatsu, Jun-Ichi Furukawa, Masatsugu Ohara, Takashi Kitagataya, Naoki Kawagishi, Masato Nakai, Takuya Sho, Koji Ogawa, Naoya Sakamoto: Long non-coding RNA PWRN4 associated with post-SVR hepatocellular carcinoma: a genome-wide association study. Biomark Res. 2025.09; 13 (1): 113. ( PubMed , DOI )

  14. Shun Kaneko, Yasuhiro Asahina, Miyako Murakawa, Shunsuke Ueyama, Hideki Watanabe, Chiaki Maeyashiki, Akiko Kusano-Kitazume, Ayako Sato, Kozue Uchidate, Taro Watabe, Takehito Asakawa, Sho Watanabe, Junko Fujiki, Isamu Shibata, Shinya Oooka, Hitoshi Kurata, Mao Tsuchiya, Takashi Fujii, Keiichi Akahoshi, Daisuke Ban, Kento Inada, Tsubasa Nobusawa, Tomohiro Mochida, Keiya Watakabe, Taro Shimizu, Jun Tsuchiya, Masato Miyoshi, Fukiko Kawai-Kitahata, Sayuri Nitta, Mina Nakagawa, Sei Kakinuma, Ryuichi Okamoto, : Effect of Immunotherapy on Late Elderly Patients With Unresectable Hepatocellular Carcinoma: A Real-World Clinical Study. Cancer Med. 2025.09; 14 (17): e71171. ( PubMed , DOI )

  15. Yasuhiro Nemoto, Ryo Morikawa, Yuki Yonemoto, Shohei Tanaka, Yuria Takei, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Tetsuya Nakamura, Kento Takenaka, Kazuo Ohtsuka, Xigui Chen, Hitoshi Okazawa, Ryuichi Okamoto, Mamoru Watanabe, Ulrich H von Andrian: Intestinal CD4-CD8αβ-TCRαβ+ T cells function as tolerogenic antigen presenting cells in mice. Nature Communications. 2025.08; 16 (1): 7072. ( PubMed , DOI )

  16. Kawai-Kitahata Fukiko, Asahina Yasuhiro, Kakinuma Sei, Inada Kento, Mochida Tomohiro, Watakabe Keiya, Nobusawa Tsubasa, Shimizu Taro, Tsuchiya Jun, Miyoshi Masato, Kaneko Shun, Murakawa Miyako, Nitta Sayuri, Nakagawa Mina, Kinowaki Yuko, Ban Daisuke, Tanaka Shinji, Anzai Tatsuhiko, Takano Shinichi, Maekawa Shinya, Enomoto Nobuyuki, Okamoto Ryuichi: Genetic alterations in hepatocellular carcinoma after sustained virological response in relation to the molecular characterization of metabolic diseases(タイトル和訳中) Hepatology Research. 2025.08; 55 (8): 1193-1203. ( ichushi )

  17. Fukiko Kawai-Kitahata, Yasuhiro Asahina, Sei Kakinuma, Kento Inada, Tomohiro Mochida, Keiya Watakabe, Tsubasa Nobusawa, Taro Shimizu, Jun Tsuchiya, Masato Miyoshi, Shun Kaneko, Miyako Murakawa, Sayuri Nitta, Mina Nakagawa, Yuko Kinowaki, Daisuke Ban, Shinji Tanaka, Tatsuhiko Anzai, Shinichi Takano, Shinya Maekawa, Nobuyuki Enomoto, Ryuichi Okamoto: Genetic alterations in hepatocellular carcinoma after sustained virological response in relation to the molecular characterization of metabolic diseases. Hepatol Res. 2025.08; 55 (8): 1193-1203. ( PubMed , DOI )

  18. Shoen Kume, Yoichi Tagawa, Ryuichi Okamoto, Hiroshi Kawasaki: Editorial - Advances in cell, tissue, organ engineering, and organoid technology. Eur J Cell Biol. 2025.06; 151499. ( PubMed , DOI )

  19. Taro Shimizu, Masato Miyoshi, Sei Kakinuma, Jun Tsuchiya, Daisuke Yamane, Keiya Watakabe, Tomohiro Mochida, Kento Inada, Kaho Yamada, Kotomi Shinozaki, Ayako Sato, Shun Kaneko, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Mina Nakagawa, Mamoru Watanabe, Yasuhiro Asahina, Ryuichi Okamoto: Bile acid-FXR signaling facilitates the long-term maintenance of hepatic characteristics in human iPSC-derived organoids. Cell Rep. 2025.05; 44 (5): 115675. ( PubMed , DOI )

  20. Risako Kohya, Goki Suda, Masatsugu Ohara, Shunichi Hosoda, Takuya Sho, Makoto Chuma, Atsumasa Komori, Yuki Kugiyama, Yutaka Yasui, Kaoru Tsuchiya, Masayuki Kurosaki, Joji Tani, Shun Kaneko, Mina Nakagawa, Yasuhiro Asahina, Shinya Maekawa, Nobuyuki Enomoto, Yoshiya Yamamoto, Masaru Baba, Ren Yamada, Takashi Sasaki, Tomoka Yoda, Sonoe Yoshida, Qingjie Fu, Zijian Yang, Osamu Maehara, Shunsuke Ohnishi, Yoshimasa Tokuchi, Takashi Kitagataya, Naoki Kawagishi, Masato Nakai, Mitsuteru Natsuizaka, Koji Ogawa, Naoya Sakamoto: Serum FGF21 as a predictor of response to atezolizumab and bevacizumab in HCC. JHEP Rep. 2025.05; 7 (5): 101364. ( PubMed , DOI )

  21. Hisatoshi Hanamatsu, Goki Suda, Masatsugu Ohara, Koji Ogawa, Nobuharu Tamaki, Hayato Hikita, Hiroaki Haga, Shinya Maekawa, Masaya Sugiyama, Tatsuhiko Kakisaka, Masato Nakai, Takuya Sho, Nobuaki Miura, Masayuki Kurosaki, Yasuhiro Asahina, Akinobu Taketomi, Yoshiyuki Ueno, Tetsuo Takehara, Takashi Nishikaze, Jun-Ichi Furukawa, Naoya Sakamoto: Elevated A2F bisect N-glycans of serum IgA reflect progression of liver fibrosis in patients with MASLD. J Gastroenterol. 2025.04; 60 (4): 456-468. ( PubMed , DOI )

  22. Makoto Naganuma, Hisashi Shiga, Masayuki Shimoda, Minoru Matsuura, Kento Takenaka, Toshimitsu Fujii, Shojiro Yamamoto, Mao Matsubayashi, Taku Kobayashi, Nobuo Aoyama, Daisuke Saito, Kaoru Yokoyama, Kei Moriya, Kiichiro Tsuchiya, Shunsuke Shibui, Ami Kawamoto, Hiromichi Shimizu, Ryuichi Okamoto, Kazuki Sakamoto, Katsuki Yaguchi, Reiko Kunisaki, Shintaro Akiyama, Ryohei Hayashi, Keisuke Hasui, Shuji Kanmura, Shigeki Bamba, Yoshiyuki Mishima, Kazuki Kakimoto, Shinya Sugimoto, Atsushi Nakazawa, Takayuki Abe, Haruhiko Ogata, Tadakazu Hisamatsu, : First-line biologics as a treatment for ulcerative colitis: a multicenter randomized control study. J Gastroenterol. 2025.04; 60 (4): 430-441. ( PubMed , DOI )

  23. Ryosuke Hamamura, Masanori Kobayashi, Ryuichi Okamoto: Endoscopic transpapillary gallbladder drainage using a novel cholangioscope. Dig Endosc. 2025.04; 37 (4): 434-435. ( PubMed , DOI )

  24. Eri Oshina, Masanori Kobayashi, Ryuichi Okamoto: Functional Gallbladder Disorder: Characteristic Hepatobiliary Scintigraphy Findings. Intern Med. 2025.04; 64 (7): 1119-1120. ( PubMed , DOI )

  25. Akiko Tamura, Hiromichi Shimizu, Toshimitsu Fujii, Ami Kawamoto, Ryo Morikawa, Shuji Hibiya, Kento Takenaka, Masakazu Nagahori, Kazuo Ohtsuka, Ryuichi Okamoto: Comparative short-term efficacy of upadacitinib versus tofacitinib for ulcerative colitis: a 24-week real-world study in Japan. Intest Res. 2025.03; ( PubMed , DOI )

  26. Hady Yuki Sugihara, Ryuichi Okamoto, Tomohiro Mizutani: Intestinal organoids: The path towards clinical application. Eur J Cell Biol. 2025.03; 104 (1): 151474. ( PubMed , DOI )

  27. Shintaro Akiyama, Hiromichi Shimizu, Akiko Tamura, Kaoru Yokoyama, Toshiyuki Sakurai, Mariko Kobayashi, Makoto Eizuka, Shunichi Yanai, Kei Nomura, Tomoyoshi Shibuya, Masahiro Takahara, Sakiko Hiraoka, Minako Sako, Atsushi Yoshida, Kozo Tsuruta, Shinichiro Yoshioka, Miki Koroku, Teppei Omori, Masayuki Saruta, Takayuki Matsumoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Toshimitsu Fujii: Comparative Efficacy and Safety of Three Janus Kinase Inhibitors in Ulcerative Colitis: A Real-World Multicentre Study in Japan. Aliment Pharmacol Ther. 2025.02; 61 (3): 524-537. ( PubMed , DOI )

  28. H Katsuda, M Kobayashi, R Okamoto: Gastrointestinal: Rupture of a pancreaticoduodenal artery aneurysm after endoscopic sphincterotomy in a case of median arcuate ligament syndrome. J Gastroenterol Hepatol. 2025.01; 40 (1): 8-9. ( PubMed , DOI )

  29. Jun Tsuchiya, Masato Miyoshi, Sei Kakinuma, Fukiko Kawai-Kitahata, Akihide Kamiya, Taro Shimizu, Ayako Sato, Keiya Watakabe, Tomohiro Mochida, Kento Inada, Rion Kamimae, Shun Kaneko, Miyako Murakawa, Sayuri Nitta, Mina Nakagawa, Mamoru Watanabe, Yasuhiro Asahina, Ryuichi Okamoto: Hepatitis B Virus-KMT2B Integration Drives Hepatic Oncogenic Processes in a Human Gene-edited Induced Pluripotent Stem Cells-derived Model. Cell Mol Gastroenterol Hepatol. 2025; 19 (2): 101422. ( PubMed , DOI )

  30. Tsubasa Ishikawa, Tomoaki Tashima, Tomonori Kawasaki, Kankei Fujimoto, Kei Sugimoto, Takahiro Shin, Takahiro Muramatsu, Yumi Mashimo, Shomei Ryozawa: Red dichromatic imaging enhances submucosal visibility during endoscopic submucosal dissection: Pilot study. Endosc Int Open. 2025; 13 a25923546. ( PubMed , DOI )

  31. Kenta Takaura, Kaoru Tsuchiya, Mina Taguchi, Yuzuki Tokunaga, Naoki Uchihara, Shohei Kimura, Yuuki Tanaka, Junko Yagita, Haruka Miyamoto, Taisei Keitoku, Risa Okada, Mayu Higuchi, Shohei Tanaka, Chiaki Maeyashiki, Nobuharu Tamaki, Yutaka Yasui, Yuka Takahashi, Hiroyuki Nakanishi, Namiki Izumi, Masayuki Kurosaki: Clinical outcome of radiofrequency ablation in patients with hepatocellular carcinoma aged 80 years and older. PLoS One. 2025; 20 (10): e0334712. ( PubMed , DOI )

  32. Ryo Morikawa, Toshimitsu Fujii, Akiko Tamura, Ami Kawamoto, Shuji Hibiya, Kento Takenaka, Hiromichi Shimizu, Kazuo Ohtsuka, Ryuichi Okamoto: Real-World Data on the Effectiveness of Ustekinumab and Risankizumab for Crohn's Disease. Inflamm Intest Dis. 2025; 10 (1): 285-289. ( PubMed , DOI )

  33. Shintaro Akiyama, Hiromichi Shimizu, Akiko Tamura, Kaoru Yokoyama, Toshiyuki Sakurai, Mariko Kobayashi, Makoto Eizuka, Shunichi Yanai, Kei Nomura, Tomoyoshi Shibuya, Masahiro Takahara, Sakiko Hiraoka, Minako Sako, Atsushi Yoshida, Kozo Tsuruta, Shinichiro Yoshioka, Miki Koroku, Teppei Omori, Masayuki Saruta, Takayuki Matsumoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Toshimitsu Fujii: Efficacy and Safety of Three Janus Kinase Inhibitors in Ulcerative Colitis Patients over and under 65 Years of Age: A Real-World Comparative Analysis. Inflamm Intest Dis. 2025; 10 (1): 180-186. ( PubMed , DOI )

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  2. Yotaro Motomura, Kota Yoshifuji, Keisuke Tanaka, Chizuko Sakashita, Yoshihiro Umezawa, Toshikage Nagao, Sayuri Nitta, Yasuhiro Asahina, Takehiko Mori, Masahide Yamamoto: Hepatitis C virus-related hepatitis flare after immunochemotherapy in a patient with follicular lymphoma. J Clin Exp Hematop. 2024.12; 64 (4): 313-317. ( PubMed , DOI )

  3. Tomohiro Mizutani, Matteo Boretto, Sangho Lim, Jarno Drost, Diego Montiel González, Rurika Oka, Maarten H Geurts, Harry Begthel, Jeroen Korving, Johan H van Es, Ruben van Boxtel, Hans Clevers: Recapitulating the adenoma-carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids. Nat Cancer. 2024.12; 5 (12): 1852-1867. ( PubMed , DOI )

  4. Yuki Tanisaka, Masafumi Mizuide, Akashi Fujita, Takahiro Shin, Kei Sugimoto, Ryuhei Jinushi, Shomei Ryozawa: Peroral cholangioscopy-guided lithotripsy using a novel thin cholangioscope under balloon enteroscopy for Roux-en-Y anastomosis. Endoscopy. 2024.12; 56 (S 01): E360-E361. ( PubMed , DOI )

  5. Yuki Tanisaka, Masafumi Mizuide, Akashi Fujita, Takahiro Shin, Kei Sugimoto, Ryuhei Jinushi, Shomei Ryozawa: Successful cannulation using a novel rotatable sphincterotome in a hepaticojejunal anastomotic stricture with a steep angle. Endoscopy. 2024.12; 56 (S 01): E336-E337. ( PubMed , DOI )

  6. Yuki Tanisaka, Masafumi Mizuide, Akashi Fujita, Takahiro Shin, Kei Sugimoto, Ryuhei Jinushi, Shomei Ryozawa: Successful cholangioscopy-guided cannulation using a novel slim cholangioscope in a patient with Roux-en-Y gastrectomy. Endoscopy. 2024.12; 56 (S 01): E158-E159. ( PubMed , DOI )

  7. Yuki Tanisaka, Masafumi Mizuide, Akashi Fujita, Takahiro Shin, Kei Sugimoto, Ryuhei Jinushi, Shomei Ryozawa: Inspection of intraductal papillary mucinous neoplasm via the papilla using a novel slim pancreatoscope under balloon enteroscopy. Endoscopy. 2024.12; 56 (S 01): E80-E82. ( PubMed , DOI )

  8. Yuki Tanisaka, Masafumi Mizuide, Akashi Fujita, Takahiro Shin, Kei Sugimoto, Ryuhei Jinushi, Shomei Ryozawa: Successful cholangioscopy-guided biopsy using a novel thin cholangioscope under balloon enteroscopy in a patient with Roux-en-Y gastrectomy. Endoscopy. 2024.12; 56 (S 01): E256-E257. ( PubMed , DOI )

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  10. Kento Takenaka, Tadakazu Hisamatsu, Taku Kobayashi, Hironori Yamamoto, Naoki Ohmiya, Ryohei Hayashi, Katsuyoshi Matsuoka, Masayuki Saruta, Akira Andoh, Norimasa Fukata, Kenji Watanabe, Hiroyuki Imaeda, Fumihito Hirai, Takayuki Matsumoto, Akihiro Hirakawa, Tomonori Yano, Minoru Matsuura, Ryuichi Okamoto, Kazuo Ohtsuka, Mamoru Watanabe: Inadequate Efficacy of Biologics for Treating Proximal Ileal Lesions in Crohn's Disease; A Prospective Multicenter Study. Clin Gastroenterol Hepatol. 2024.12; Online ahead of print ( PubMed , DOI )

  11. Murakawa Miyako, Nakagawa Mina, Nishimura Hisaaki, Kaneko Shun, Miyoshi Masato, Kawai-Kitahata Fukiko, Nitta Sayuri, Tsuchiya Jun, Shimizu Taro, Watakabe Keiya, Mochida Tomohiro, Inada Kento, Iizuka Yasuhiro, Sakai Hideki, Sakurai Yuki, Sato Ayako, Azuma Seishin, Kawamura Takahiro, Maeyashiki Chiaki, Kurosaki Masayuki, Kusano Fumihiko, Watanabe Hideki, Kurata Hitoshi, Karakama Yuko, Fujiwara Takeo, Nagata Yuki, Tanaka Toshihiro, Kakinuma Sei, Okamoto Ryuichi, Asahina Yasuhiro: High serum gamma-glutamyltransferase level after hepatitis C virus elimination is a risk factor for the development of hepatocellular carcinoma(タイトル和訳中) Hepatology Research. 2024.12; 54 (12): 1128-1138. ( ichushi )

  12. Hiromune Katsuda, Masanori Kobayashi, Go Ito, Ami Kawamoto, Susumu Krimura, Hiroyuki Sato, Akihiro Hirakawa, Keiichi Akahoshi, Atsushi Kudo, Kazuo Ohtsuka, Ryuichi Okamoto: Evaluating endoscopic ultrasound-guided tissue acquisition for diagnosis of small pancreatic neuroendocrine neoplasms. Endosc Int Open. 2024.11; 12 (11): E1379-E1385. ( PubMed , DOI )

  13. Shun Ishido, Masanori Kobayashi, Ryuichi Okamoto: Low-cost and reliable method for confirming residual bile duct stones utilizing a novel peroral cholangioscope. Dig Endosc. 2024.10; 36 (10): 1173-1175. ( PubMed , DOI )

  14. Yuki Tahata, Hayato Hikita, Satoshi Mochida, Nobuyuki Enomoto, Norifumi Kawada, Akio Ido, Daiki Miki, Masayuki Kurosaki, Hitoshi Yoshiji, Ryotaro Sakamori, Hidekatsu Kuroda, Hiroshi Yatsuhashi, Taro Yamashita, Yoichi Hiasa, Naoya Kato, Hisamitsu Miyaaki, Yoshiyuki Ueno, Yoshito Itoh, Kentaro Matsuura, Taro Takami, Yasuhiro Asahina, Goki Suda, Norio Akuta, Ryosuke Tateishi, Yasunari Nakamoto, Eiji Kakazu, Shuji Terai, Masahito Shimizu, Masanori Miyazaki, Yasutoshi Nozaki, Satoshi Sobue, Hiroki Yano, Tomokatsu Miyaki, Akihiro Moriuchi, Takeshi Hori, Kumiko Shirai, Kazuhiro Murai, Yoshinobu Saito, Takahiro Kodama, Tomohide Tatsumi, Tomomi Yamada, Tetsuo Takehara: Factors involved in gastroesophageal varix-related events in patients with hepatitis C virus-related compensated and decompensated cirrhosis after direct-acting antiviral therapy. Hepatol Res. 2024.10; ( PubMed , DOI )

  15. Yuki Tanisaka, Mamoru Takenaka, Masafumi Mizuide, Akashi Fujita, Ryuhei Jinushi, Takahiro Shin, Kei Sugimoto, Ken Kamata, Kosuke Minaga, Shunsuke Omoto, Tomohiro Yamazaki, Shomei Ryozawa: Efficacy of texture and color enhancement imaging for short-type single-balloon enteroscopy-assisted biliary cannulation in patients with Roux-en-Y gastrectomy: Multicenter study (with video). Dig Endosc. 2024.09; 36 (9): 1030-1040. ( PubMed , DOI )

  16. Masanori Kobayashi, Mao Niimi, Hiromune Katsuda, Keiichi Akahoshi, Yuko Kinowaki, Masanao Sasaki, Akihiro Hirakawa, Ukihide Tateishi, Minoru Tanabe, Ryuichi Okamoto: Optimization of Endoscopic Ultrasound Characteristics in the Diagnosis of Malignant Intraductal Papillary Mucinous Neoplasm. Pancreas. 2024.07; 53 (6): e521-e527. ( PubMed , DOI )

  17. Shimizu H, Aonuma Y, Hibiya S, Kawamoto A, Takenaka K, Fujii T, Saito E, Nagahori M, Ohtsuka K, Okamoto R: Long-term efficacy and safety of tofacitinib in patients with ulcerative colitis: 3-year results from a real-world study. Intestinal research. 2024.07; ( PubMed , DOI )

  18. Hiromune Katsuda, Masanori Kobayashi, Ryuichi Okamoto: Endoscopic recanalization of an occluded Braun anastomosis using an endoscopic injection needle. Dig Endosc. 2024.07; 36 (7): 851-852. ( PubMed , DOI )

  19. Haruki Uojima, Kazumi Yamasaki, Masaya Sugiyama, Masayoshi Kage, Norihiro Ishii, Ken Shirabe, Hisashi Hidaka, Chika Kusano, Miyako Murakawa, Yasuhiro Asahina, Takashi Nishimura, Hiroko Iijima, Kazumasa Sakamoto, Kiyoaki Ito, Keisuke Amano, Takumi Kawaguchi, Nobuharu Tamaki, Masayuki Kurosaki, Takanori Suzuki, Kentaro Matsuura, Akinobu Taketomi, Satoru Joshita, Takeji Umemura, Sohji Nishina, Keisuke Hino, Hidenori Toyoda, Hiroshi Yatsuhashi, Masashi Mizokami: Quantitative measurements of M2BPGi depend on liver fibrosis and inflammation. J Gastroenterol. 2024.07; 59 (7): 598-608. ( PubMed , DOI )

  20. Watakabe K, Miyoshi M, Kakinuma S, Sato A, Tsuchiya J, Shimizu T, Mochida T, Inada K, Kaneko S, Kawai-Kitahata F, Murakawa M, Nitta S, Nakagawa M, Oshima S, Watanabe M, Ma A, Asahina Y, Okamoto R: A20 in hepatic stellate cells suppresses chronic hepatitis by inhibiting DCLK1-JNK pathway-dependent chemokines. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2024.07; 38 (13): e23757. ( PubMed , DOI )

  21. Kazuma Saito, Masanori Kobayashi, Minato Yokoyama, Towako Taguchi, Koichiro Kimura, Takumi Akashi, Yasuhisa Fujii, Ryuichi Okamoto: Transjejunal fine-needle biopsy using a forward-viewing echoendoscope for diagnosis of a rare hereditary paraganglioma. VideoGIE. 2024.07; 9 (7): 329-332. ( PubMed , DOI )

  22. Kaneko Shun, Asahina Yasuhiro, Murakawa Miyako, Ueyama Shunsuke, Maeyashiki Chiaki, Watanabe Hideki, Kusano-Kitazume Akiko, Sato Ayako, Uchidate Kozue, Asakawa Takehito, Watanabe Sho, Iizuka Yasuhiro, Shibata Isamu, Oooka Shinya, Karakama Yuko, Fujii Takashi, Watabe Taro, Akahoshi Keiichi, Tanabe Minoru, Inada Kento, Mochida Tomohiro, Watakabe Keiya, Shimizu Taro, Tsuchiya Jun, Miyoshi Masato, Kitahata-Kawai Fukiko, Nitta Sayuri, Nakagawa Mina, Kakinuma Sei, Okamoto Ryuichi: Prognostic significance of C-reactive protein in unresectable hepatocellular carcinoma treated with atezolizumab and bevacizumab Hepatology Research. 2024.06; 54 (6): 562-574. ( ichushi )

  23. Shun Kaneko, Yasuhiro Asahina, Miyako Murakawa, Shunsuke Ueyama, Chiaki Maeyashiki, Hideki Watanabe, Akiko Kusano-Kitazume, Ayako Sato, Kozue Uchidate, Takehito Asakawa, Sho Watanabe, Yasuhiro Iizuka, Isamu Shibata, Shinya Oooka, Yuko Karakama, Takashi Fujii, Taro Watabe, Keiichi Akahoshi, Minoru Tanabe, Kento Inada, Tomohiro Mochida, Keiya Watakabe, Taro Shimizu, Jun Tsuchiya, Masato Miyoshi, Fukiko Kitahata-Kawai, Sayuri Nitta, Mina Nakagawa, Sei Kakinuma, Ryuichi Okamoto, : Prognostic significance of C-reactive protein in unresectable hepatocellular carcinoma treated with atezolizumab and bevacizumab. Hepatol Res. 2024.06; 54 (6): 562-574. ( PubMed , DOI )

  24. Tatsuya Suzuki, Yuka Hayakawa, Shun Kaneko, Kento Takenaka, Keiya Watakabe, Yuko Kinowaki, Akira Takemoto, Kazuo Ohtsuka, Yasuhiro Asahina, Ryuichi Okamoto: Granulomatous hepatitis with Crohn's disease: a case report. Clin J Gastroenterol. 2024.06; 17 (3): 551-556. ( PubMed , DOI )

  25. Shintaro Akiyama, Kaoru Yokoyama, Soichi Yagi, Shinichiro Shinzaki, Kozo Tsuruta, Shinichiro Yoshioka, Minako Sako, Hiromichi Shimizu, Mariko Kobayashi, Toshiyuki Sakurai, Kei Nomura, Tomoyoshi Shibuya, Masahiro Takahara, Sakiko Hiraoka, Kyohei Sugai, Shunichi Yanai, Atsushi Yoshida, Miki Koroku, Teppei Omori, Masayuki Saruta, Takayuki Matsumoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Toshimitsu Fujii: Efficacy and safety of filgotinib for ulcerative colitis: A real-world multicenter retrospective study in Japan. Aliment Pharmacol Ther. 2024.06; 59 (11): 1413-1424. ( PubMed , DOI )

  26. Keito Suzuki, Yutaka Yasui, Kaoru Tsuchiya, Hiroaki Matsumoto, Yudai Yamazaki, Naoki Uchihara, Yuki Tanaka, Haruka Miyamoto, Michiko Yamada-Shimizu, Taisei Keitoku, Risa Okada, Mayu Higuchi, Kenta Takaura, Shohei Tanaka, Chiaki Maeyashiki, Nobuharu Tamaki, Hiroyuki Nakanishi, Yuka Takahashi, Yasuhiro Asahina, Ryuichi Okamoto, Masayuki Kurosaki, Namiki Izumi: Impact of immune-related adverse events in patients with hepatocellular carcinoma treated with atezolizumab plus bevacizumab. J Gastroenterol Hepatol. 2024.06; 39 (6): 1183-1189. ( PubMed , DOI )

  27. Yuki Tanisaka, Masafumi Mizuide, Akashi Fujita, Ryuhei Jinushi, Rie Shiomi, Takahiro Shin, Kei Sugimoto, Tomoaki Tashima, Yumi Mashimo, Shomei Ryozawa: 22-gauge Co-Cr versus stainless-steel Franseen needles for endoscopic ultrasound-guided tissue acquisition in patients with solid pancreatic lesions. Clin Endosc. 2024.03; 57 (2): 237-245. ( PubMed , DOI )

  28. Yuki Tanisaka, Masafumi Mizuide, Akashi Fujita, Takahiro Shin, Kei Sugimoto, Ryuhei Jinushi, Shomei Ryozawa: A novel balloon dilation catheter facilitating endoscopic papillary balloon dilation in patients with Roux-en-Y gastrectomy. VideoGIE. 2024.03; 9 (3): 137-140. ( PubMed , DOI )

  29. Nobuhiko Ogasawara, Yoshihito Kano, Yosuke Yoneyama, Sakurako Kobayashi, Satoshi Watanabe, Sakura Kirino, Fausto D Velez-Bravo, Yourae Hong, Aleksandra Ostapiuk, Pavlo Lutsik, Iichiroh Onishi, Shinichi Yamauchi, Yui Hiraguri, Go Ito, Yusuke Kinugasa, Kenichi Ohashi, Mamoru Watanabe, Ryuichi Okamoto, Sabine Tejpar, Shiro Yui: Discovery of non-genomic drivers of YAP signaling modulating the cell plasticity in CRC tumor lines. iScience. 2024.03; 27 (3): 109247. ( PubMed , DOI )

  30. Kaneko S, Asahina Y, Murakawa M, Azuma S, Inada K, Mochida T, Watakabe K, Shimizu T, Tsuchiya J, Miyoshi M, Kawai-Kitahata F, Nitta S, Takahashi M, Fujioka T, Kishino M, Anzai T, Kakinuma S, Nakagawa M, Okamoto R: Analysis of prognosis and background liver disease in non-advanced hepatocellular carcinoma in two decades. PLoS ONE. 2024.03; 19 (3): e0297882. ( PubMed , DOI )

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  32. Shun Fujiwara, Yoshihito Kano, Yasuhiro Maejima, Tomoyuki Fujioka, Kazuhiro Tamura, Susumu Kirimura, Satoshi Miyake, Ryuichi Okamoto: Clinical Response of Primary Malignant Pericardial Mesothelioma with Peritoneal Dissemination to Nivolumab. Intern Med. 2024.02; 63 (4): 513-519. ( PubMed , DOI )

  33. Ami Kawamoto, Kento Takenaka, Shuji Hibiya, Yoshio Kitazume, Hiromichi Shimizu, Toshimitsu Fujii, Eiko Saito, Kazuo Ohtsuka, Ryuichi Okamoto: Combination of leucine-rich alpha-2 glycoprotein and fecal markers detect Crohn's disease activity confirmed by balloon-assisted enteroscopy. Intest Res. 2024.01; 22 (1): 65-74. ( PubMed , DOI )

  34. Miwa Himuro, Yuka Wakabayashi, Tomomi Taguchi, Takehiro Katahira, Luka Suzuki, Hitoshi Iida, Takeshi Ogihara, Yuya Nishida, Shugo Sasaki, Francis C Lynn, Yuichi Hiraoka, Shigeru Oshima, Ryuichi Okamoto, Yoshio Fujitani, Hirotaka Watada, Takeshi Miyatsuka: Novel time-resolved reporter mouse reveals spatial and transcriptional heterogeneity during alpha cell differentiation. Diabetologia. 2024.01; 67 (1): 156-169. ( PubMed , DOI )

  35. Yuki Yonemoto, Yasuhiro Nemoto, Ryo Morikawa, Nana Shibayama, Shigeru Oshima, Takashi Nagaishi, Tomohiro Mizutani, Go Ito, Satoru Fujii, Ryuichi Okamoto: T cell subsets were increased in the small intestinal intraepithelial lymphocytes of aged mice. Front Immunol. 2024.01; 15 1340048. ( PubMed , DOI )

  36. Okamoto T, Ishizuka T, Shimizu R, Asahina Y, Nakamura H, Shimizu Y, Nishida Y, Yokota T, Lin Y, Sato W, Yamamura T: Efficacy and Safety of the Natural Killer T Cell-Stimulatory Glycolipid OCH-NCNP1 for Patients With Relapsing Multiple Sclerosis: Protocol for a Randomized Placebo-Controlled Clinical Trial. JMIR research protocols. 2024.01; 13 e46709. ( PubMed , DOI )

  37. Taniai T, Shimada S, Akiyama Y, Hatano M, Yasukawa K, Igarashi Y, Tsukihara S, Tanji Y, Kodera K, Okazaki K, Haruki K, Nara A, Yagi K, Akahoshi K, Ban D, Asahina Y, Ikegami T, Tanabe M, Tanaka S. : Integrative transcriptome profiling elucidates molecular and immunovascular characteristics of macrotrabecular hepatocellular carcinoma. Hepatology. 2024; in press.

  38. Shun Kaneko, Yasuhiro Asahina, Miyako Murakawa, Seishin Azuma, Kento Inada, Tomohiro Mochida, Keiya Watakabe, Taro Shimizu, Jun Tsuchiya, Masato Miyoshi, Fukiko Kawai-Kitahata, Sayuri Nitta, Marie Takahashi, Tomoyuki Fujioka, Mitsuhiro Kishino, Tatsuhiko Anzai, Sei Kakinuma, Mina Nakagawa, Ryuichi Okamoto: Analysis of prognosis and background liver disease in non-advanced hepatocellular carcinoma in two decades. PLoS One. 2024; 19 (3): e0297882. ( PubMed , DOI )

  39. Masanori Kobayashi, Hiromune Katsuda, Aya Maekawa, Keiichi Akahoshi, Ryosuke Watanabe, Yuko Kinowaki, Hisaaki Nishimura, Takeo Fujiwara, Minoru Tanabe, Ryuichi Okamoto: Development of an intraductal papillary mucinous neoplasm malignancy prediction scoring system. PLoS One. 2024; 19 (10): e0312234. ( PubMed , DOI )

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  2. Yuki Tanisaka, Masafumi Mizuide, Akashi Fujita, Rie Shiomi, Takahiro Shin, Kei Sugimoto, Shomei Ryozawa: Usefulness of a novel sphincterotome for transpancreatic biliary sphincterotomy to achieve selective biliary cannulation in patients with Roux-en-Y gastrectomy. Endoscopy. 2023.12; 55 (S 01): E651-E653. ( PubMed , DOI )

  3. Yuki Tanisaka, Masafumi Mizuide, Akashi Fujita, Rie Shiomi, Takahiro Shin, Masanori Yasuda, Shomei Ryozawa: Usefulness of texture and color enhancement imaging in peroral cholangioscopy. Endoscopy. 2023.12; 55 (S 01): E58-E59. ( PubMed , DOI )

  4. Yuki Tanisaka, Masafumi Mizuide, Akashi Fujita, Rie Shiomi, Takahiro Shin, Dai Hirata, Shomei Ryozawa: Texture and color enhancement imaging facilitates the identification of pancreatic and bile duct orifices after endoscopic papillectomy. Endoscopy. 2023.12; 55 (S 01): E22-E23. ( PubMed , DOI )

  5. Yuki Tanisaka, Masafumi Mizuide, Akashi Fujita, Rie Shiomi, Takahiro Shin, Dai Hirata, Shomei Ryozawa: Use of texture and color enhancement imaging to identify the pancreatic duct orifice in a patient with a pancreaticojejunal anastomotic stricture. Endoscopy. 2023.12; 55 (S 01): E88-E89. ( PubMed , DOI )

  6. Nanako Hashido, Masanori Kobayashi, Ami Kawamoto, Suguru Mabuchi, Hiromune Katsuda, Kazuo Ohtsuka, Yasuhiro Asahina, Masayoshi Hashimoto, Ryuichi Okamoto: Sphincter of Oddi dysfunction that could not be diagnosed with Rome IV: a case report. Clin J Gastroenterol. 2023.12; 16 (6): 913-918. ( PubMed , DOI )

  7. Haruki Uojima, Kadzuki Nakabayashi, Kazumi Yamasaki, Masaya Sugiyama, Norihiro Ishii, Ken Shirabe, Takuya Kyoutou, Koji Ueda, Yoichi Takahama, Nobuharu Tamaki, Masayuki Kurosaki, Hisashi Hidaka, Chika Kusano, Keisuke Amano, Takumi Kawaguchi, Akinobu Taketomi, Satoru Joshita, Takeji Umemura, Miyako Murakawa, Yasuhiro Asahina, Takanori Suzuki, Kentaro Matsuura, Takashi Nishimura, Hiroko Iijima, Kazumasa Sakamoto, Kiyoaki Ito, Sohji Nishina, Keisuke Hino, Hidenori Toyoda, Hiroshi Yatsuhashi, Masayoshi Kage, Masashi Mizokami: New chemiluminescent enzyme immunoassay for quantitative measurement of Mac-2 binding protein glycosylation isomer in chronic liver disease. J Gastroenterol. 2023.12; 58 (12): 1252-1260. ( PubMed , DOI )

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  9. Shuji Hibiya, Takashi Fujii, Toshimitsu Fujii, Shinji Suzuki, Mayumi Kondo, Shinya Ooka, Yohei Furumoto, Seishin Azuma, Kei Tanaka, Hitoshi Kurata, Shohei Tanaka, Masayuki Kurosaki, Kazuyoshi Nagayama, Fumihiko Kusano, Yasuhiro Iizuka, Takahiro Kawamura, Hidekazu Ikemiyagi, Shinya Sakita, Tsunehito Yauchi, Hideki Watanabe, Ami Kawamoto, Yusuke Matsuyama, Kazuo Ohtsuka, Ryuichi Okamoto: COVID-19 severity is associated with the risk of gastrointestinal bleeding. BMJ Open Gastroenterol. 2023.11; 10 (1): e001199. ( PubMed , DOI )

  10. Yuki Tanisaka, Masafumi Mizuide, Akashi Fujita, Rie Shiomi, Takahiro Shin, Kei Sugimoto, Shomei Ryozawa: Single-balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography in patients with surgically altered anatomy: a technical review. Clin Endosc. 2023.11; 56 (6): 716-725. ( PubMed , DOI )

  11. Kirino Sakura, Tamaki Nobuharu, Kurosaki Masayuki, Takahashi Yuka, Higuchi Mayu, Itakura Yoshie, Tanaka Yuki, Inada Kento, Ishido Shun, Yamashita Koji, Nobusawa Tsubasa, Matsumoto Hiroaki, Hayakawa Yuka, Kakegawa Tatsuya, Takaura Kenta, Tanaka Shohei, Maeyashiki Chiaki, Kaneko Shun, Yasui Yutaka, Tsuchiya Kaoru, Nakanishi Hiroyuki, Okamoto Ryuichi, Izumi Namiki: Detecting advanced liver fibrosis using ultrasound shear wave velocity measurement in the general population QUANTITATIVE IMAGING IN MEDICINE AND SURGERY. 2023.10; 13 (10): 6493-6502. ( PubMed , DOI )

  12. Masanori Kobayashi, Hiromune Katsuda, Kazuo Ohtsuka, Ryuichi Okamoto: Comparison of guidewires for successful cannulation of biliary stenosis and targeting of biliary branches in ERCP. Endosc Int Open. 2023.09; 11 (9): E805-E810. ( PubMed , DOI )

  13. Kentaro Miyamoto, Tomohisa Sujino, Yosuke Harada, Hiroshi Ashida, Yusuke Yoshimatsu, Yuki Yonemoto, Yasuhiro Nemoto, Michio Tomura, Hassan Melhem, Jan Hendrik Niess, Toshihiko Suzuki, Toru Suzuki, Shohei Suzuki, Yuzo Koda, Ryuichi Okamoto, Yohei Mikami, Toshiaki Teratani, Kenji F. Tanaka, Akihiko Yoshimura, Toshiro Sato, Takanori Kanai: The gut microbiota-induced kynurenic acid recruits GPR35-positive macrophages to promote experimental encephalitis. Cell Rep. 2023.08; 42 (8): 113005. ( PubMed , DOI )

  14. Takayuki Yamamoto, Hiroshi Nakase, Kenji Watanabe, Shinichiro Shinzaki, Noritaka Takatsu, Toshimitsu Fujii, Ryuichi Okamoto, Katsuyoshi Matsuoka, Akihiro Yamada, Reiko Kunisaki, Minoru Matsuura, Hisashi Shiga, Shigeki Bamba, Yohei Mikami, Takahiro Shimoyama, Satoshi Motoya, Takehiro Torisu, Taku Kobayashi, Naoki Ohmiya, Masayuki Saruta, Koichiro Matsuda, Takayuki Matsumoto, Atsuo Maemoto, Yoko Murata, Shinichi Yoshigoe, Shinya Nagasaka, Tsutomu Yajima, Tadakazu Hisamatsu, : Diagnosis and Clinical Features of Perianal Lesions in Newly Diagnosed Crohn's Disease: Subgroup Analysis from Inception Cohort Registry Study of Patients with Crohn's Disease (iCREST-CD). J Crohns Colitis. 2023.08; 17 (8): 1193-1206. ( PubMed , DOI )

  15. Morimoto K, Ueda H, Asano D, Ishikawa Y, Watanabe S, Akahoshi K, Ono H, Kobayashi M, Okamoto R, Tanaka S, Tanabe M: Incidence and Mechanism of Refractory Postoperative Cholangitis After Hepatectomy with Hepaticojejunostomy. J Gastrointest Surg. 2023.08; 27 (8): 1668-1676. ( PubMed , DOI )

  16. Watanabe Sho, Uchida Hitoshi, Fujii Ryosuke, Uga Misugi, Machida Tomoyo, Matsukawa Naoki, Kurihara Masamichi, Negi Mariko, Yauchi Tsunehito: ステロイド依存性好酸球性腸炎(EoN)成人患者に対するデュピルマブによる導入および維持療法の有効性(The efficacy of dupilumab in induction and maintenance of remission in an adult patient with steroid-dependent eosinophilic enteritis(EoN)) Clinical Journal of Gastroenterology. 2023.08; 16 (4): 527-531. ( ichushi )

  17. Yuki Tanisaka, Masafumi Mizuide, Akashi Fujita, Rie Shiomi, Takahiro Shin, Dai Hirata, Kei Sugimoto, Shomei Ryozawa: Usefulness of texture- and color-enhancement imaging for identifying the bleeding point in a patient with post-endoscopic sphincterotomy bleeding. VideoGIE. 2023.07; 8 (7): 269-271. ( PubMed , DOI )

  18. Ishido S, Tamaki N, Inada K, Itakura J, Takahashi Y, Uchihara N, Suzuki K, Tanaka Y, Miyamoto H, Yamada M, Matsumoto H, Nobusawa T, Keitoku T, Takaura K, Tanaka S, Maeyashiki C, Yasui Y, Tsuchiya K, Nakanishi H, Kurosaki M, Izumi N: Pemigatinib treatment for intrahepatic cholangiocarcinoma with FGFR2 fusion detected by a liquid comprehensive genomic profiling test. Clinical case reports. 2023.07; 11 (7): e7664. ( PubMed , DOI )

  19. Kento Takenaka, Ami Kawamoto, Yoshio Kitazume, Toshimitsu Fujii, Yumi Udagawa, Hiromichi Shimizu, Shuji Hibiya, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto: Transmural Remission Characterized by High Biologic Concentrations Demonstrates Better Prognosis in Crohn's Disease. J Crohns Colitis. 2023.06; 17 (6): 855-862. ( PubMed , DOI )

  20. Kento Takenaka, Yoshio Kitazume, Ami Kawamoto, Toshimitsu Fujii, Yumi Udagawa, Ryosuke Wanatabe, Hiromichi Shimizu, Shuji Hibiya, Masakazu Nagahori, Kazuo Ohtsuka, Hiroyuki Sato, Akihiro Hirakawa, Mamoru Watanabe, Ryuichi Okamoto: Serum Leucine-Rich α2 Glycoprotein: A Novel Biomarker for Transmural Inflammation in Crohn's Disease. Am J Gastroenterol. 2023.06; 118 (6): 1028-1035. ( PubMed , DOI )

  21. Ryuhei Jinushi, Sakue Masuda, Yuki Tanisaka, Sho Nishiguchi, Kento Shionoya, Ryo Sato, Kei Sugimoto, Takahiro Shin, Rie Shiomi, Akashi Fujita, Masafumi Mizuide, Shomei Ryozawa: Comparison of serum acylcarnitine levels in patients with myalgic encephalomyelitis/chronic fatigue syndrome and healthy controls: a systematic review and meta-analysis. J Transl Med. 2023.06; 21 (1): 398. ( PubMed , DOI )

  22. Ryuhei Jinushi, Masafumi Mizuide, Yuki Tanisaka, Sakue Masuda, Kazuya Koizumi, Akiko Sasaki, Yo Ishihara, Kento Shionoya, Ryo Sato, Kei Sugimoto, Takahiro Shin, Rie Shiomi, Akashi Fujita, Shomei Ryozawa, Tsutomu Yamazaki: Efficacy for diagnoses of scirrhous gastric cancer and safety of endoscopic ultrasound-guided fine-needle aspiration: A systematic review and meta-analysis. JGH Open. 2023.06; 7 (6): 403-409. ( PubMed , DOI )

  23. Katsuyoshi Matsuoka, Toshimitsu Fujii, Ryuichi Okamoto, Akihiro Yamada, Reiko Kunisaki, Minoru Matsuura, Kenji Watanabe, Hisashi Shiga, Noritaka Takatsu, Shigeki Bamba, Yohei Mikami, Takayuki Yamamoto, Takahiro Shimoyama, Satoshi Motoya, Takehiro Torisu, Taku Kobayashi, Naoki Ohmiya, Masayuki Saruta, Koichiro Matsuda, Takayuki Matsumoto, Hiroshi Nakase, Atsuo Maemoto, Shinichiro Shinzaki, Yoko Murata, Shinichi Yoshigoe, Ayako Sasaki, Tsutomu Yajima, Tadakazu Hisamatsu, : Correction: Characteristics of adult patients newly diagnosed with Crohn's disease: interim analysis of the nation-wide inception cohort registry study of patients with Crohn's disease in Japan (iCREST-CD). J Gastroenterol. 2023.06; 58 (6): 602-603. ( PubMed , DOI )

  24. Junichi Takahashi, Hady Yuki Sugihara, Shu Kato, Sayaka Nagata, Ryuichi Okamoto, Tomohiro Mizutani: Protocol to generate large human intestinal organoids using a rotating bioreactor. STAR Protocols. 2023.06; 4 (3): 102374. ( PubMed , DOI )

  25. Kaneko Shun, Asahina Yasuhiro, Nakagawa Mina, Murakawa Miyako, Miyazaki Yasunari, Asakage Takahiro, Fukuda Shohei, Namiki Takeshi, Kano Yoshihito, Nagata Masashi, Tsuchiya Jun, Miyoshi Masato, Kitahata-Kawai Fukiko, Nitta Sayuri, Itsui Yasuhiro, Kakinuma Sei, Okamoto Ryuichi: Factors associated with liver injury and prognosis in advanced cancer patients treated with immune checkpoint inhibitors(タイトル和訳中) Hepatology Research. 2023.05; 53 (5): 450-459. ( ichushi )

  26. Mina Nakagawa, Yasuhiro Asahina, Sei Kakinuma, Ryuichi Okamoto: Impact of eradication of hepatitis C virus on liver-related and -unrelated diseases: morbidity and mortality of chronic hepatitis C after SVR. J Gastroenterol. 2023.04; 58 (4): 299-310. ( PubMed , DOI )

  27. Hayakawa Yuka, Tamaki Nobuharu, Nakanishi Hiroyuki, Kurosaki Masayuki, Tanaka Yuki, Inada Kento, Ishido Shun, Kirino Sakura, Yamashita Koji, Nobusawa Tsubasa, Matsumoto Hiroaki, Kakegawa Tatsuya, Higuchi Mayu, Takaura Kenta, Tanaka Shohei, Maeyashiki Chiaki, Kaneko Shun, Yasui Yutaka, Takahashi Yuka, Tsuchiya Kaoru, Okamoto Ryuichi, Izumi Namiki: 治療抵抗性肝性脳症に対するリファキシミン追加投与の効果(Add-on Therapeutic Effects of Rifaximin on Treatment-resistant Hepatic Encephalopathy) Internal Medicine. 2023.04; 62 (7): 973-978. ( ichushi )

  28. Watanabe Satoshi, Ogasawara Nobuhiko, Kobayashi Sakurako, Kirino Sakura, Inoue Masami, Hiraguri Yui, Nagata Sayaka, Shimizu Hiromichi, Ito Go, Mizutani Tomohiro, Nemoto Yasuhiro, Tsuchiya Kiichiro, Okamoto Ryuichi, Watanabe Mamoru, Yui Shiro: 膜保護性スルホムチン濃縮セグメントを創製するための上皮シグネチャ設計のための新しいモダリティとしてのオルガノイド移植(Organoids transplantation as a new modality to design epithelial signature to create a membrane-protective sulfomucin-enriched segment) Journal of Gastroenterology. 2023.04; 58 (4): 379-393. ( ichushi )

  29. Satoshi Watanabe, Nobuhiko Ogasawara, Sakurako Kobayashi, Sakura Kirino, Masami Inoue, Yui Hiraguri, Sayaka Nagata, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Yasuhiro Nemoto, Kiichiro Tsuchiya, Ryuichi Okamoto, Mamoru Watanabe, Shiro Yui: Organoids transplantation as a new modality to design epithelial signature to create a membrane-protective sulfomucin-enriched segment. J Gastroenterol. 2023.04; 58 (4): 379-393. ( PubMed , DOI )

  30. Taisei Keitoku, Nobuharu Tamaki, Masayuki Kurosaki, Kento Inada, Sakura Kirino, Naoki Uchihara, Keito Suzuki, Yuki Tanaka, Haruka Miyamoto, Shun Ishido, Michiko Yamada, Tsubasa Nobusawa, Hiroaki Matsumoto, Mayu Higuchi, Kenta Takaura, Shohei Tanaka, Chiaki Maeyashiki, Shun Kaneko, Yutaka Yasui, Yuka Takahashi, Kaoru Tsuchiya, Hiroyuki Nakanishi, Yasuhiro Asahina, Ryuichi Okamoto, Namiki Izumi: Effect of fatty liver and fibrosis on hepatocellular carcinoma development in patients with chronic hepatitis B who received nucleic acid analog therapy. J Viral Hepat. 2023.04; 30 (4): 297-302. ( PubMed , DOI )

  31. Mina Nakagawa, Yasuhiro Asahina, Sei Kakinuma, Ryuichi Okamoto: Correction: Impact of eradication of hepatitis C virus on liver-related and -unrelated diseases: morbidity and mortality of chronic hepatitis C after SVR. J Gastroenterol. 2023.04; 58 (4): 311-312. ( PubMed , DOI )

  32. Fujiwara S, Kawamoto A, Motobayashi M, Hibiya S, Takenaka K, Shimizu H, Saito E, Fujii T, Nagahori M, Kawata D, Umezawa N, Hosoya T, Yasuda S, Ohtsuka K, Okamoto R: Hemorrhagic gastric ulcer in a patient with Behcet's disease successfully treated with infliximab. DEN open. 2023.04; 3 (1): e196. ( PubMed , DOI )

  33. Daiki Yamada, Yudai Kojima, Akinori Hosoya, Masahiro Suzuki, Taro Watabe, Tadahiko Inoue, Naoya Tsugawa, Takehito Asakawa, Yuki Yonemoto, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Motoyuki Shimonaka, Keiji Kuba, Junji Ishida, Akiyoshi Fukamizu, Josef M Penninger, Mamoru Watanabe, Ryuichi Okamoto, Takashi Nagaishi: Apelin expression is downregulated in T cells in a murine model of chronic colitis. Biochem Biophys Res Commun. 2023.03; 647 72-79. ( PubMed , DOI )

  34. Yuki Tanisaka, Masafumi Mizuide, Akashi Fujita, Ryuhei Jinushi, Rie Shiomi, Takahiro Shin, Dai Hirata, Rie Terada, Tomoaki Tashima, Yumi Mashimo, Shomei Ryozawa: Can endoscopic retrograde cholangiopancreatography-related procedures for resolving acute cholangitis be effectively and safely performed in patients with surgically altered anatomy? Comparison study to evaluate the timing of short-type single-balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography. Dig Endosc. 2023.03; 35 (3): 361-368. ( PubMed , DOI )

  35. Naoki Ikeda, Hiroaki Kubota, Risa Suzuki, Mitsuki Morita, Ayana Yoshimura, Yuya Osada, Keigo Kishida, Daiki Kitamura, Ayaka Iwata, Satoshi Yotsumoto, Daisuke Kurotaki, Koutarou Nishimura, Akira Nishiyama, Tomohiko Tamura, Takashi Kamatani, Tatsuhiko Tsunoda, Miyako Murakawa, Yasuhiro Asahina, Yoshihiro Hayashi, Hironori Harada, Yuka Harada, Asumi Yokota, Hideyo Hirai, Takao Seki, Makoto Kuwahara, Masakatsu Yamashita, Shigeyuki Shichino, Masato Tanaka, Kenichi Asano: The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis. Cell Rep. 2023.03; 42 (3): 112165. ( PubMed , DOI )

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  37. Yuki Tanisaka, Masafumi Mizuide, Akashi Fujita, Ryuhei Jinushi, Rie Shiomi, Takahiro Shin, Dai Hirata, Rie Terada, Tomoaki Tashima, Yumi Mashimo, Shomei Ryozawa: Endoscopic ultrasound‑guided biliary drainage in patients with surgically altered anatomy: a systematic review and Meta‑analysis. Scand J Gastroenterol. 2023.02; 58 (2): 107-115. ( PubMed , DOI )

  38. Shun Ishido, Kaoru Tsuchiya, Yoshihito Kano, Yutaka Yasui, Kenta Takaura, Naoki Uchihara, Keito Suzuki, Yuki Tanaka, Haruka Miyamoto, Michiko Yamada, Hiroaki Matsumoto, Tsubasa Nobusawa, Taisei Keitoku, Shohei Tanaka, Chiaki Maeyashiki, Nobuharu Tamaki, Yuka Takahashi, Hiroyuki Nakanishi, Urara Sakurai, Yasuhiro Asahina, Ryuichi Okamoto, Masayuki Kurosaki, Namiki Izumi: Clinical Utility of Comprehensive Genomic Profiling in Patients with Unresectable Hepatocellular Carcinoma. Cancers (Basel). 2023.01; 15 (3): 719. ( PubMed , DOI )

  39. Kaneko S, Asahina Y, Nakagawa M, Murakawa M, Miyazaki Y, Asakage T, Fukuda S, Namiki T, Kano Y, Nagata M, Tsuchiya J, Miyoshi M, Kitahata-Kawai F, Nitta S, Itsui Y, Kakinuma S, Okamoto R: Factors associated with liver injury and prognosis in advanced cancer patients treated with immune checkpoint inhibitors. Hepatology research : the official journal of the Japan Society of Hepatology. 2023.01; 53 (5): 450-459. ( PubMed , DOI )

  40. Kirino Sakura, Tamaki Nobuharu, Kurosaki Masayuki, Kaneko Shun, Inada Kento, Tanaka Yuki, Ishido Shun, Yamashita Koji, Nobusawa Tsubasa, Matsumoto Hiroaki, Hayakawa Yuka, Kakegawa Tatsuya, Higuchi Mayu, Takaura Kenta, Tanaka Shohei, Maeyashiki Chiaki, Yasui Yutaka, Takahashi Yuka, Tsuchiya Kaoru, Nakanishi Hiroyuki, Okamoto Ryuichi, Izumi Namiki: Alanine aminotransferase levels as therapeutic targets after nucleotide/nucleoside analog therapy in patient with chronic hepatitis B(タイトル和訳中) Hepatology Research. 2023.01; 53 (1): 35-42. ( ichushi )

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  42. Shokichi Takahama, Sachiyo Yoshio, Yuji Masuta, Hirotomo Murakami, Ryotaro Sakamori, Shun Kaneko, Takashi Honda, Miyako Murakawa, Masaya Sugiyama, Masayuki Kurosaki, Yasuhiro Asahina, Tetsuo Takehara, Victor Appay, Tatsuya Kanto, Takuya Yamamoto: T cell quality. Front Immunol. 2023; 14 1257113. ( PubMed , DOI )

  1. Takahashi J, Mizutani T, Sugihara HY, Nagata S, Kato S, Hiraguri Y, Takeoka S, Tsuchiya M, Kuno R, Kakinuma S, Watanabe M, Okamoto R: Suspension culture in a rotating bioreactor for efficient generation of human intestinal organoids. Cell Reports Methods. 2022.11; 2 (11): 100337. ( PubMed , DOI )

  2. Yamashita K, Kurosaki M, Nakanishi H, Tanaka Y, Ishido S, Inada K, Kirino S, Hayakawa Y, Matsumoto H, Nobusawa T, Kakegawa T, Higuchi M, Takaura K, Tanaka S, Maeyashiki C, Kaneko S, Tamaki N, Yasui Y, Tsuchiya K, Takahashi Y, Miyazaki R, Ashikaga T, Enomoto N, Izumi N: Simple algorithm to narrow down the candidates to receive echocardiography in patients with chronic liver disease for suspected pulmonary hypertension. JGH open : an open access journal of gastroenterology and hepatology. 2022.11; 6 (11): 774-781. ( PubMed , DOI )

  3. Kobayashi Sakurako, Ogasawara Nobuhiko, Watanabe Satoshi, Yoneyama Yosuke, Kirino Sakura, Hiraguri Yui, Inoue Masami, Nagata Sayaka, Okamoto-Uchida Yoshimi, Kofuji Satoshi, Shimizu Hiromichi, Ito Go, Mizutani Tomohiro, Yamauchi Shinichi, Kinugasa Yusuke, Kano Yoshihito, Nemoto Yasuhiro, Watanabe Mamoru, Tsuchiya Kiichiro, Nishina Hiroshi, Okamoto Ryuichi, Yui Shiro: Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation(タイトル和訳中) Inflammation and Regeneration. 2022.11; 42 1 of 18-18 of 18. ( ichushi )

  4. Katsuyoshi Matsuoka, Toshimitsu Fujii, Ryuichi Okamoto, Akihiro Yamada, Reiko Kunisaki, Minoru Matsuura, Kenji Watanabe, Hisashi Shiga, Noritaka Takatsu, Shigeki Bamba, Yohei Mikami, Takayuki Yamamoto, Takahiro Shimoyama, Satoshi Motoya, Takehiro Torisu, Taku Kobayashi, Naoki Ohmiya, Masayuki Saruta, Koichiro Matsuda, Takayuki Matsumoto, Hiroshi Nakase, Atsuo Maemoto, Shinichiro Shinzaki, Yoko Murata, Shinichi Yoshigoe, Ayako Sasaki, Tsutomu Yajima, Tadakazu Hisamatsu: Characteristics of adult patients newly diagnosed with Crohn's disease: interim analysis of the nation-wide inception cohort registry study of patients with Crohn's disease in Japan (iCREST-CD). J Gastroenterol. 2022.11; 57 (11): 867-878. ( PubMed , DOI )

  5. Ami Kawamoto, Kento Takenaka, Ryuichi Okamoto, Mamoru Watanabe, Kazuo Ohtsuka: Systematic review of artificial intelligence-based image diagnosis for inflammatory bowel disease. Dig Endosc. 2022.11; 34 (7): 1311-1319. ( PubMed , DOI )

  6. Sakurako Kobayashi, Nobuhiko Ogasawara, Satoshi Watanabe, Yosuke Yoneyama, Sakura Kirino, Yui Hiraguri, Masami Inoue, Sayaka Nagata, Yoshimi Okamoto-Uchida, Satoshi Kofuji, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Shinichi Yamauchi, Yusuke Kinugasa, Yoshihito Kano, Yasuhiro Nemoto, Mamoru Watanabe, Kiichiro Tsuchiya, Hiroshi Nishina, Ryuichi Okamoto, Shiro Yui: Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation. Inflamm Regen. 2022.11; 42 (1): 49. ( PubMed , DOI )

  7. Shuhei Sekiguchi, Kaoru Tsuchiya, Yutaka Yasui, Kento Inada, Sakura Kirino, Koji Yamashita, Yuka Hayakawa, Leona Osawa, Mayu Higuchi, Kenta Takaura, Chiaki Maeyashiki, Shun Kaneko, Nobuharu Tamaki, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Yasuhiro Asahina, Ryuichi Okamoto, Masayuki Kurosaki, Namiki Izumi: Clinical usefulness of geriatric assessment in elderly patients with unresectable hepatocellular carcinoma receiving sorafenib or lenvatinib therapy. Cancer Rep (Hoboken). 2022.11; 5 (11): e1613. ( PubMed , DOI )

  8. Fujiwara S, Kobayashi M, Ohtsuka K, Tanabe M, Okamoto R: The Double-Max method: a novel method for gallbladder epithelial biopsy. VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy. 2022.09; 7 (9): 334-336. ( PubMed , DOI )

  9. Hayakawa Y, Tamaki N, Nakanishi H, Kurosaki M, Tanaka Y, Inada K, Ishido S, Kirino S, Yamashita K, Nobusawa T, Matsumoto H, Kakegawa T, Higuchi M, Takaura K, Tanaka S, Maeyashiki C, Kaneko S, Yasui Y, Takahashi Y, Tsuchiya K, Okamoto R, Izumi N: Add-on Therapeutic Effects of Rifaximin on Treatment-resistant Hepatic Encephalopathy. Internal medicine (Tokyo, Japan). 2022.09; 62 (7): 973-978. ( PubMed , DOI )

  10. Kirino S, Tamaki N, Kurosaki M, Kaneko S, Inada K, Tanaka Y, Ishido S, Yamashita K, Nobusawa T, Matsumoto H, Hayakawa Y, Kakegawa T, Higuchi M, Takaura K, Tanaka S, Maeyashiki C, Yasui Y, Takahashi Y, Tsuchiya K, Nakanishi H, Okamoto R, Izumi N: Alanine aminotransferase levels as therapeutic targets after nucleotide/nucleoside analog therapy in patient with chronic hepatitis B. Hepatology research : the official journal of the Japan Society of Hepatology. 2022.09; 53 (1): 35-42. ( PubMed , DOI )

  11. Kimura S, Onishi I, Kobayashi M: A Rare Case of Esophageal Metastasis of Invasive Mucinous Adenocarcinoma of the Lung. ACG case reports journal. 2022.08; 9 (8): e00857. ( PubMed , DOI )

  12. Ami Kawamoto, Toshimitsu Fujii, Ryuji Mitani, Yasuhiro Suzuki, Tsunehito Yauchi, Ryuichi Okamoto: Serum Levels of Infliximab Biosimilar in a Child Delivered From a Mother Treated for Ulcerative Colitis. Inflamm Bowel Dis. 2022.08; 28 (8): 1298-1299. ( PubMed , DOI )

  13. Noji R, Tohyama K, Kugimoto T, Kuroshima T, Hirai H, Tomioka H, Michi Y, Tasaki A, Ohno K, Ariizumi Y, Onishi I, Suenaga M, Mori T, Okamoto R, Yoshimura R, Miura M, Asakage T, Miyake S, Ikeda S, Harada H, Kano Y: Comprehensive Genomic Profiling Reveals Clinical Associations in Response to Immune Therapy in Head and Neck Cancer. Cancers. 2022.07; 14 (14): ( PubMed , DOI )

  14. Hiroaki Matsumoto, Kaoru Tsuchiya, Hiroyuki Nakanishi, Yuka Hayakawa, Yutaka Yasui, Naoki Uchihara, Keito Suzuki, Yuki Tanaka, Haruka Miyamoto, Shun Ishido, Michiko Yamada, Taisei Keitoku, Tsubasa Nobusawa, Mayu Higuchi, Kenta Takaura, Shohei Tanaka, Chiaki Maeyashiki, Nobuharu Tamaki, Yuka Takahashi, Masayuki Kurosaki, Yasuhiro Asahina, Ryuichi Okamoto, Namiki Izumi: Clinical Usefulness of Monitoring Muscle Volume during Atezolizumab Plus Bevacizumab Therapy in Patients with Unresectable Hepatocellular Carcinoma. Cancers (Basel). 2022.07; 14 (14): ( PubMed , DOI )

  15. Leona Osawa, Hiroyuki Nakanishi, Masayuki Kurosaki, Sakura Kirino, Kento Inada, Koji Yamashita, Yuka Hayakawa, Shuhei Sekiguchi, Wan Wang, Mao Okada, Mayu Higuchi, Yasuyuki Komiyama, Kenta Takaura, Hitomi Takada, Shun Kaneko, Chiaki Maeyashiki, Nobuharu Tamaki, Yutaka Yasui, Kaoru Tsuchiya, Jun Itakura, Yuka Takahashi, Nobuyuki Enomoto, Namiki Izumi: Plasma Renin Activity Predicts Prognosis and Liver Disease-Related Events in Liver Cirrhosis Patients with Ascites Treated by Tolvaptan. Digestive Diseases. 2022.07; 40 (4): 479-488. ( PubMed , DOI )

  16. Kazumi Takishima, Yasuharu Maeda, Noriyuki Ogata, Masashi Misawa, Yuichi Mori, Mayumi Homma, Tetsuo Nemoto, Yuki Miyata, Yoshika Akimoto, Kentaro Mochida, Yuki Takashina, Kenta Tanaka, Katsuro Ichimasa, Hiroki Nakamura, Seiko Sasanuma, Toyoki Kudo, Takemasa Hayashi, Kunihiko Wakamura, Hideyuki Miyachi, Toshiyuki Baba, Fumio Ishida, Kazuo Ohtsuka, Shin-Ei Kudo: Beyond complete endoscopic healing: Goblet appearance using an endocytoscope to predict future sustained clinical remission in ulcerative colitis. Dig Endosc. 2022.07; 34 (5): 1030-1039. ( PubMed , DOI )

  17. Watanabe Sho, Uchida Hitoshi, Nanke Ittoku, Uchidate Kozue, Machida Tomoyo, Igarashi Akira, Kobashi Kenichiro, Negi Mariko, Fujii Takashi, Yauchi Tsunehito: 長期経過観察中に早期大腸癌およびCMV関連潰瘍を併発した大腸限局野生型ATTRアミロイドーシスの一例(A case of localized colorectal wild-type ATTR amyloidosis complicated by early stage colorectal cancer and a CMV-associated ulcer during the long-term follow-up) Clinical Journal of Gastroenterology. 2022.06; 15 (3): 603-610. ( ichushi )

  18. Kaneko S, Tsuchiya K, Yasui Y, Tanaka Y, Inada K, Ishido S, Kirino S, Yamashita K, Hayakawa Y, Nobusawa T, Matsumoto H, Kakegawa T, Higuchi M, Takaura K, Tanaka S, Maeyashiki C, Tamaki N, Takahashi Y, Nakanishi H, Irie T, Ariizumi SI, Kurosaki M, Izumi N: Conversion surgery for hepatocellular carcinoma after tyrosine kinase inhibitor treatment. JGH open : an open access journal of gastroenterology and hepatology. 2022.05; 6 (5): 301-308. ( PubMed , DOI )

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  20. Kento Inada, Nobuharu Tamaki, Masayuki Kurosaki, Sakura Kirino, Koji Yamashita, Yuka Hayakawa, Mayu Higuchi, Kenta Takaura, Shun Kaneko, Chiaki Maeyashiki, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Namiki Izumi: Validation of magnetic resonance elastography plus fibrosis-4 for significant fibrosis in nonalcoholic fatty liver disease. Journal of Gastroenterology and Hepatology. 2022.05; 37 (9): 1726-1731. ( PubMed , DOI )

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  4. Shun Kaneko, Kaoru Tsuchiya, Yutaka Yasui, Kento Inada, Sakura Kirino, Koji Yamashita, Leona Osawa, Yuka Hayakawa, Shuhei Sekiguchi, Mayu Higuchi, Kenta Takaura, Chiaki Maeyashiki, Nobuharu Tamaki, Takaya Takeguchi, Yuko Takeguchi, Takuya Nagano, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Yoshiro Himeno, Akihiko Hoshi, Masayuki Kurosaki, Namiki Izumi: Strategy for advanced hepatocellular carcinoma based on liver function and portal vein tumor thrombosis. Hepatol Res. 2020.12; 50 (12): 1375-1385. ( PubMed , DOI )

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  9. Yasuhiro Asahina, Chun-Jen Liu, Edward Gane, Yoshito Itoh, Norifumi Kawada, Yoshiyuki Ueno, Jin Youn, Chen-Yu Wang, Joe Llewellyn, Takuma Matsuda, Anuj Gaggar, Hongmei Mo, Hadas Dvory-Sobol, Gerald Crans, Wan-Long Chuang, Pei-Jer Chen, Nobuyuki Enomoto: Twelve weeks of ledipasvir/sofosbuvir all-oral regimen for patients with chronic hepatitis C genotype 2 infection: Integrated analysis of three clinical trials. Hepatol Res. 2020.10; 50 (10): 1109-1117. ( PubMed , DOI )

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  1. Fukiko Kawai-Kitahata, Yasuhiro Asahina, Shun Kaneko, Jun Tsuchiya, Ayako Sato, Masato Miyoshi, Tomoyuki Tsunoda, Emi Inoue-Shinomiya, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Sei Kakinuma, Minoru Tanabe, Emiko Sugawara, Akira Takemoto, Hidenori Ojima, Michiie Sakamoto, Masaru Muraoka, Shinichi Takano, Shinya Maekawa, Nobuyuki Enomoto, Mamoru Watanabe: Comprehensive genetic analysis of cholangiolocellular carcinoma with a coexistent hepatocellular carcinoma-like area and metachronous hepatocellular carcinoma. Hepatol Res. 2019.12; 49 (12): 1466-1474. ( PubMed , DOI )

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  3. Joosten SPJ, Mizutani T, Spaargaren M, Clevers H, Pals ST: MET Signaling Overcomes Epidermal Growth Factor Receptor Inhibition in Normal and Colorectal Cancer Stem Cells Causing Drug Resistance. Gastroenterology. 2019.10; 157 (4): 1153-1155.e1. ( PubMed , DOI )

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  7. Nobuharu Tamaki, Mayu Higuchi, Masayuki Kurosaki, Sakura Kirino, Leona Osawa, Keiya Watakabe, Wan Wang, Mao Okada, Takao Shimizu, Kenta Takaura, Hitomi Takada, Shun Kaneko, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Nobuyuki Enomoto, Namiki Izumi: Wisteria floribunda agglutinin-positive mac-2 binding protein as an age-independent fibrosis marker in nonalcoholic fatty liver disease. Sci Rep. 2019.07; 9 (1): 10109. ( PubMed , DOI )

  8. Nobuharu Tamaki, Mayu Higuchi, Masayuki Kurosaki, Sakura Kirino, Leona Osawa, Keiya Watakabe, Wan Wang, Mao Okada, Takao Shimizu, Kenta Takaura, Hitomi Takada, Shun Kaneko, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Nobuyuki Enomoto, Namiki Izumi: Risk assessment of hepatocellular carcinoma development by magnetic resonance elastography in chronic hepatitis C patients who achieved sustained virological responses by direct-acting antivirals. J. Viral Hepat.. 2019.07; 26 (7): 893-899. ( PubMed , DOI )

  9. Tomoyuki Tsunoda, Sei Kakinuma, Masato Miyoshi, Akihide Kamiya, Shun Kaneko, Ayako Sato, Jun Tsuchiya, Sayuri Nitta, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Tsuyoshi Sogo, Haruki Komatsu, Ryutaro Mukouchi, Ayano Inui, Tomoo Fujisawa, Hiromitsu Nakauchi, Yasuhiro Asahina, Mamoru Watanabe: Loss of fibrocystin promotes interleukin-8-dependent proliferation and CTGF production of biliary epithelium. J. Hepatol.. 2019.07; 71 (1): 143-152. ( PubMed , DOI )

  10. Hiromichi Shimizu, Kohei Suzuki, Mamoru Watanabe, Ryuichi Okamoto: Stem cell-based therapy for inflammatory bowel disease. Intest Res. 2019.07; 17 (3): 311-316. ( PubMed , DOI )

  11. Sander PJ Joosten, Tomohiro Mizutani, Marcel Spaargaren, Hans Clevers, Steven T Pals: MET signaling overcomes epidermal growth factor receptor inhibition in normal and colorectal cancer stem cells causing drug resistance. Gastroenterology. 2019.06; 157 1153-1155.

  12. Emi Inoue-Shinomiya, Miyako Murakawa, Yasuhiro Asahina, Mina Nakagawa, Jun Tsuchiya, Ayako Sato, Tomoyuki Tsunoda, Masato Miyoshi, Sayuri Nitta, Fukiko Kawai-Kitahata, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Kazumoto Murata, Masashi Mizokami, Mamoru Watanabe: Association of serum interferon-λ3 levels with hepatocarcinogenesis in chronic hepatitis C patients treated with direct-acting antiviral agents. Hepatol. Res.. 2019.05; 49 (5): 500-511. ( PubMed , DOI )

  13. Akira Doi, Hayato Hikita, Yugo Kai, Yuki Tahata, Yoshinobu Saito, Tasuku Nakabori, Ryoko Yamada, Takahiro Kodama, Ryotaro Sakamori, Asako Murayama, Sayuri Nitta, Yasuhiro Asahina, Hiroshi Suemizu, Tomohide Tatsumi, Takanobu Kato, Tetsuo Takehara: Combinations of two drugs among NS3/4A inhibitors, NS5B inhibitors and non-selective antiviral agents are effective for hepatitis C virus with NS5A-P32 deletion in humanized-liver mice. J. Gastroenterol.. 2019.05; 54 (5): 449-458. ( PubMed , DOI )

  14. Emi Inoue-Shinomiya, Miyako Murakawa, Yasuhiro Asahina, Mina Nakagawa, Jun Tsuchiya, Ayako Sato, Tomoyuki Tsunoda, Masato Miyoshi, Sayuri Nitta, Fukiko Kawai-Kitahata, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Kazumoto Murata, Masashi Mizokami, Mamoru Watanabe: Association of serum interferon-λ3 levels with hepatocarcinogenesis in chronic hepatitis C patients treated with direct-acting antiviral agents. Hepatol Res. 2019.05; 49 (5): 500-511. ( ichushi )

  15. Sho Watanabe, Kiichiro Tsuchiya, Ryu Nishimura, Tomoaki Shirasaki, Nobuhiro Katsukura, Shuji Hibiya, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe: Mutation by CRISPR System Enhances the Malignant Potential of Colon Cancer. Mol. Cancer Res.. 2019.04; ( PubMed , DOI )

  16. Shun Kaneko, Masayuki Kurosaki, Nobuharu Tamaki, Jun Itakura, Tsuguru Hayashi, Sakura Kirino, Leona Osawa, Keiya Watakabe, Mao Okada, Wan Wang, Takao Shimizu, Mayu Higuchi, Kenta Takaura, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Yuka Takahashi, Mamoru Watanabe, Namiki Izumi: Tenofovir alafenamide for hepatitis B virus infection including switching therapy from tenofovir disoproxil fumarate. J. Gastroenterol. Hepatol.. 2019.04; 34 (11): 2004-2010. ( PubMed , DOI )

  17. Sayuri Nitta, Yasuhiro Asahina, Takanobu Kato, Jun Tsuchiya, Emi Inoue-Shinomiya, Ayako Sato, Tomoyuki Tsunoda, Masato Miyoshi, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Sei Kakinuma, Hayato Hikita, Tetsuo Takehara, Mamoru Watanabe: Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-experienced patients. Sci Rep. 2019.04; 9 (1): 5722. ( PubMed , DOI )

  18. Ami Kawamoto, Sayaka Nagata, Sho Anzai, Junichi Takahashi, Mao Kawai, Minami Hama, Daichi Nogawa, Kouhei Yamamoto, Reiko Kuno, Kohei Suzuki, Hiromichi Shimizu, Yui Hiraguri, Shiro Yui, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Ohtsuka, Masanobu Kitagawa, Ryuichi Okamoto, Mamoru Watanabe: Ubiquitin D is upregulated by synergy of notch signalling and TNF-α in the inflamed intestinal epithelia of IBD patients. J Crohns Colitis. 2019.03; 13 (4): 495-509. ( PubMed , DOI )

  19. Masato Miyoshi, Sei Kakinuma, Akihide Kamiya, Tomoyuki Tsunoda, Jun Tsuchiya, Ayako Sato, Shun Kaneko, Sayuri Nitta, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Hiromitsu Nakauchi, Yasuhiro Asahina, Mamoru Watanabe: LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells. Sci Rep. 2019.02; 9 (1): 2072. ( PubMed , DOI )

  20. Seishin Azuma, Yasuhiro Asahina, Sei Kakinuma, Keiko Azuma, Masato Miyoshi, Emi Inoue, Tomoyuki Tsunoda, Ayako Sato, Shun Kaneko, Hiroko Nagata, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Makoto Tomita, Mina Nakagawa, Mamoru Watanabe: Diabetic Retinopathy as a Risk Factor Associated with the Development of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease. [Epub ahead of print] Dig Dis. 2019.01; 1-8. ( PubMed , DOI )

  1. Kohei Suzuki, Tatsuro Murano, Hiromichi Shimizu, Go Ito, Toru Nakata, Satoru Fujii, Fumiaki Ishibashi, Ami Kawamoto, Sho Anzai, Reiko Kuno, Konomi Kuwabara, Junichi Takahashi, Minami Hama, Sayaka Nagata, Yui Hiraguri, Kento Takenaka, Shiro Yui, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto: Single cell analysis of Crohn's disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties. J. Gastroenterol.. 2018.09; 53 (9): 1035-1047. ( PubMed , DOI )

  2. Yasuhiro Asahina, Yoshito Itoh, Yoshiyuki Ueno, Yasushi Matsuzaki, Yasuhiro Takikawa, Hiroshi Yatsuhashi, Takuya Genda, Fusao Ikeda, Takuma Matsuda, Hadas Dvory-Sobol, Deyuan Jiang, Benedetta Massetto, Anu O Osinusi, Diana M Brainard, John G McHutchison, Norifumi Kawada, Nobuyuki Enomoto: Ledipasvir-sofosbuvir for treating Japanese patients with chronic hepatitis C virus genotype 2 infection. Liver Int. 2018.09; 38 (9): 1552-1561. ( PubMed , DOI )

  3. Wai-Kay Seto, Yasuhiro Asahina, Todd T Brown, Cheng-Yuan Peng, Carol Stanciu, Dzhamal Abdurakhmanov, Fehmi Tabak, Tuan T Nguyen, Wan-Long Chuang, Tetsuro Inokuma, Fusao Ikeda, Teresa Antonia Santantonio, François Habersetzer, Alnoor Ramji, Audrey H Lau, Vithika Suri, John F Flaherty, Hongyuan Wang, Anuj Gaggar, G Mani Subramanian, Shrikant Mukewar, Maurizia R Brunetto, Scott Fung, Henry Lik-Yuen Chan: Improved Bone Safety of Tenofovir Alafenamide Compared to Tenofovir Disoproxil Fumarate Over 2 Years in Patients With Chronic HBV Infection.[Epub ahead of print] Clin. Gastroenterol. Hepatol. 2018.06; ( PubMed , DOI )

  4. Maekawa Shinya, Sato Mitsuaki, Kuratomi Natsuhiko, Inoue Taisuke, Suzuki Yuichiro, Tatsumi Akihisa, Miura Mika, Matsuda Shuya, Muraoka Masaru, Nakakuki Natsuko, Amemiya Fumitake, Takano Shinichi, Fukasawa Mitsuharu, Nakayama Yasuhiro, Yamaguchi Tatsuya, Sato Tadashi, Sakamoto Minoru, Murakawa Miyako, Nakagawa Mina, Asahina Yasuhiro, Enomoto Nobuyuki: Association between alanine aminotransferase elevation and UGT1A1*6 polymorphisms in daclatasvir and asunaprevir combination therapy for chronic hepatitis C J. Gastroenterol. 2018.06; 53 (6): 780-786. ( ichushi )

  5. Yutaka Yasui, Kaoru Tsuchiya, Masayuki Kurosaki, Takaya Takeguchi, Yuko Takeguchi, Mao Okada, Wan Wang, Yohei Kubota, Tomoyuki Goto, Yasuyuki Komiyama, Mayu Higuchi, Kenta Takaura, Tsuguru Hayashi, Hitomi Takada, Nobuharu Tamaki, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Yasuhiro Asahina, Nobuyuki Enomoto, Yoshiro Himeno, Namiki Izumi: Up-to-seven criteria as a useful predictor for tumor downstaging to within Milan criteria and Child-Pugh grade deterioration after initial conventional transarterial chemoembolization. Hepatol. Res. 2018.05; 48 (6): 442-450. ( PubMed , DOI )

  6. Hiroko Nagata, Mina Nakagawa, Yasuhiro Asahina: Reply to: "Imaging Basis of AFP and WFA+M2BP as Indicators of the risk of HCC after SVR". J. Hepatol. 2018.03; 68 (3): 607-608. ( PubMed , DOI )

  7. Taro Watabe, Takashi Nagaishi, Naoya Tsugawa, Yudai Kojima, Nisha Jose, Akinori Hosoya, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Tetsuya Nakamura, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe: B cell activation in the cecal patches during the development of an experimental colitis model Biochem. Biophys. Res. Commun.. 2018.02; 496 (2): 367-373. ( PubMed , DOI )

  1. Fumiaki Ishibashi, Hiromichi Shimizu, Toru Nakata, Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Sho Anzai, Reiko Kuno, Sayaka Nagata, Go Ito, Tatsuro Murano, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe, Ryuichi Okamoto: Contribution of ATOH1+ Cells to the Homeostasis, Repair, and Tumorigenesis of the Colonic Epithelium. [Epub ahead of print] Stem Cell Reports. 2017.12; ( PubMed , DOI )

  2. Yoichi Nibe, Shigeru Oshima, Masanori Kobayashi, Chiaki Maeyashiki, Yu Matsuzawa, Kana Otsubo, Hiroki Matsuda, Emi Aonuma, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Shinichiro Nakada, Mamoru Watanabe: Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by SQSTM1/p62. Autophagy. 2017.11; 14 (2): 1-43. ( PubMed , DOI )

  3. Shinya Maekawa, Mitsuaki Sato, Natsuhiko Kuratomi, Taisuke Inoue, Yuichiro Suzuki, Akihisa Tatsumi, Mika Miura, Shuya Matsuda, Masaru Muraoka, Natsuko Nakakuki, Fumitake Amemiya, Shinichi Takano, Mitsuharu Fukasawa, Yasuhiro Nakayama, Tatsuya Yamaguchi, Tadashi Sato, Minoru Sakamoto, Miyako Murakawa, Mina Nakagawa, Yasuhiro Asahina, Nobuyuki Enomoto: Association between alanine aminotransferase elevation and UGT1A1*6 polymorphisms in daclatasvir and asunaprevir combination therapy for chronic hepatitis C. J. Gastroenterol.. 2017.11; ( PubMed , DOI )

  4. Hiroko Nagata, Mina Nakagawa, Yasuhiro Asahina, Ayako Sato, Yu Asano, Tomoyuki Tsunoda, Masato Miyoshi, Shun Kaneko, Satoshi Otani, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Toshihiko Nouchi, Hideki Sakai, Makoto Tomita, Mamoru Watanabe: Effect of interferon-based and -free therapy on early occurrence and recurrence of hepatocellular carcinoma in chronic hepatitis C. J. Hepatol. 2017.11; 67 (5): 933-939. ( PubMed , DOI )

  5. Kaneko Shun, Kakinuma Sei, Asahina Yasuhiro, Kamiya Akihide, Miyoshi Masato, Tsunoda Tomoyuki, Inoue-Shinomiya Emi, Nitta Sayuri, Sato Ayako, Asano Yu, Nagata Hiroko, Kawai-Kitahata Fukiko, Murakawa Miyako, Itsui Yasuhiro, Nakagawa Mina, Azuma Seishin, Watanabe Mamoru: A novel culture model for coinfection of hepatitis B and hepatitis C viruses using human induced pluripotent stem cell-derived hepatic cells for analyses of changes in host-innate immune responses HEPATOLOGY. 2017.10; 66 69A.

  6. Nakagawa Mina, Asahina Yasuhiro, Nagata Hiroko, Kaneko Shun, Kawai-Kitahata Fukiko, Murakawa Miyako, Nitta Sayuri, Itsui Yasuhiro, Azuma Seishin, Kakinuma Sei, Tanaka Yujiro, Watanabe Mamoru: Evaluation of an early occurrence and recurrence of hepatocellular carcinoma in chronic hepatitis C patients treated with All-Oral DAAs - propensity score-matched analysis of a prospective database HEPATOLOGY. 2017.10; 66 38A-39A.

  7. Nitta Sayuri, Murakawa Miyako, Kato Takanobu, Sato Ayako, Tsunoda Tomoyuki, Miyoshi Masato, Asano Yu, Kaneko Shun, Nagata Hiroko, Kawai-Kitahata Fukiko, Itsui Yasuhiro, Nakagawa Mina, Azuma Seishin, Kakinuma Sei, Asahina Yasuhiro: The analysis of NS5A Resistance-Associated Substitutions (RAS): In vitro study of NS5A recombinant hepatitis C in infectious cell culture system for various RAS detected after treatment failure in chronic hepatitis C patients HEPATOLOGY. 2017.10; 66 480A.

  8. Murakawa Miyako, Asahina Yasuhiro, Nakagawa Mina, Nitta Sayuri, Kawai-Kitahata Fukiko, Nagata Hiroko, Kaneko Syun, Asano Yu, Miyoshi Masato, Tsunoda Tomoyuki, Inoue-Shinomiya Emi, Sato Ayako, Itsui Yasuhiro, Kakinuma Sei, Azuma Seishin, Watanabe Mamoru: On-treatment higher levels of alpha-fetoprotein and M2BPGi are associated with development of hepatocellular carcinoma during nucleos(t)ide analog therapy in patients with HBV chronic infection HEPATOLOGY. 2017.10; 66 507A.

  9. Murakawa Miyako, Asahina Yasuhiro, Nagata Hiroko, Nakagawa Mina, Kakinuma Sei, Nitta Sayuri, Kawai-Kitahata Fukiko, Otani Satoshi, Kaneko Shun, Miyoshi Masato, Tsunoda Tomoyuki, Asano Yu, Sato Ayako, Itsui Yasuhiro, Azuma Seishin, Nouchi Toshihiko, Furumoto Yohei, Asano Tooru, Chuganji Yoshimichi, Tohda Shuji, Watanabe Mamoru: ITPA gene variation and ribavirin-induced anemia in patients with genotype 2 chronic hepatitis C treated with sofosbuvir plus ribavirin Hepatology Research. 2017.10; 47 (11): 1212-1218. ( ichushi )

  10. Asahina Yasuhiro, Itoh Yoshito, Ueno Yoshiyuki, Matsuzaki Yasushi, Takikawa Yasuhiro, Yatsuhashi Hiroshi, Genda Takuya, Ikeda Fusao, Matsuda Takuma, Huang K. C., Massetto Benedetta, Osinusi Anu O., Brainard Diana M., McHutchison John G., Kawada Norifumi, Enomoto Nobuyuki: Ledipasvir/Sofosbuvir in the Treatment of Japanese Patients with Chronic HCV Genotype 2 Infection HEPATOLOGY. 2017.10; 66 638A.

  11. Tatsuro Yoneyama, Midori A Arai, Ryuta Akamine, Kazune Koryudzu, Anna Tsuchiya, Samir K Sadhu, Firoj Ahmed, Motoyuki Itoh, Ryuichi Okamoto, Masami Ishibashi: Notch Inhibitors from Calotropis gigantea That Induce Neuronal Differentiation of Neural Stem Cells. J. Nat. Prod. 2017.09; 80 (9): 2453-2461. ( PubMed , DOI )

  12. Azuma Seishin, Asahina Yasuhiro, Kakinuma Sei, Azuma Keiko, Watanabe Mamoru: Diabetic retinopathy as a risk factor associated with development of hepatocellular carcinoma in non-alcoholic fatty liver disease JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. 2017.09; 32 158.

  13. Jarno Drost, Ruben van Boxtel, Francis Blokzijl, Tomohiro Mizutani, Nobuo Sasaki, Valentina Sasselli, Joep de Ligt, Sam Behjati, Judith E Grolleman, Tom van Wezel, Serena Nik-Zainal, Roland P Kuiper, Edwin Cuppen, Hans Clevers: Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer Science. 2017.09; 358 (6360): 234-238. ( PubMed , DOI )

  14. Tamaki N, Kurosaki M, Kusakabe A, Orito E, Joko K, Kojima Y, Kimura H, Uchida Y, Hasebe C, Asahina Y, Izumi N, Japanese Red Cross Hospital Liver Study Group.: Hepatitis B surface antigen reduction by switching from long-term nucleoside/nucleotide analogue administration to pegylated interferon. Journal of viral hepatitis. 2017.08; 24 (8): 672-678. ( PubMed , DOI )

  15. Goto Fumio, Kakinuma Sei, Miyoshi Masato, Tsunoda Tomoyuki, Kaneko Shun, Sato Ayako, Asano Yu, Otani Satoshi, Azuma Seishin, Nagata Hiroko, Kawai-Kitahata Fukiko, Murakawa Miyako, Nitta Sayuri, Itsui Yasuhiro, Nakagawa Mina, Asahina Yasuhiro, Watanabe Mamoru: Bone morphogenetic protein-4 modulates proliferation and terminal differentiation of fetal hepatic stem/progenitor cells Hepatology Research. 2017.08; 47 (9): 941-952. ( ichushi )

  16. Tomohiro Mizutani, Yoshiyuki Tsukamoto, Hans Clevers: Oncogene-inducible organoids as a miniature platform to assess cancer characteristics. J. Cell Biol. 2017.06; 216 (6): 1505-1507. ( PubMed , DOI )

  17. Shuji Hibiya, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Nobukatsu Horita, Sho Watanabe, Tomoaki Shirasaki, Ryu Nishimura, Natsuko Kimura, Tatsunori Nishimura, Noriko Gotoh, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe: Long-term Inflammation Transforms Intestinal Epithelial Cells of Colonic Organoids. J Crohns Colitis. 2017.05; 11 (5): 621-630. ( PubMed , DOI )

  18. Kentaro Matsuura, Hiromi Sawai, Kazuho Ikeo, Shintaro Ogawa, Etsuko Iio, Masanori Isogawa, Noritomo Shimada, Atsumasa Komori, Hidenori Toyoda, Takashi Kumada, Tadashi Namisaki, Hitoshi Yoshiji, Naoya Sakamoto, Mina Nakagawa, Yasuhiro Asahina, Masayuki Kurosaki, Namiki Izumi, Nobuyuki Enomoto, Atsunori Kusakabe, Eiji Kajiwara, Yoshito Itoh, Tatsuya Ide, Akihiro Tamori, Misako Matsubara, Norifumi Kawada, Ken Shirabe, Eiichi Tomita, Masao Honda, Shuichi Kaneko, Sohji Nishina, Atsushi Suetsugu, Yoichi Hiasa, Hisayoshi Watanabe, Takuya Genda, Isao Sakaida, Shuhei Nishiguchi, Koichi Takaguchi, Eiji Tanaka, Junichi Sugihara, Mitsuo Shimada, Yasuteru Kondo, Yosuke Kawai, Kaname Kojima, Masao Nagasaki, Katsushi Tokunaga, Yasuhito Tanaka, : Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection. Gastroenterology. 2017.05; 152 (6): 1383-1394. ( PubMed , DOI )

  19. Yoshimoto Nomura, Taro Yamashita, Naoki Oishi, Kouki Nio, Takehiro Hayashi, Mariko Yoshida, Tomoyuki Hayashi, Tomomi Hashiba, Yasuhiro Asahina, Hikari Okada, Hajime Sunagozaka, Hajime Takatori, Masao Honda, Shuichi Kaneko: Cancer Cells by Cytotoxic Agents in Human Hepatocellular Carcinoma. Transl Oncol. 2017.04; 10 (2): 184-189. ( PubMed , DOI )

  20. Chiaki Maeyashiki, Shigeru Oshima, Kana Otsubo, Masanori Kobayashi, Yoichi Nibe, Yu Matsuzawa, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe: HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells. Biochem. Biophys. Res. Commun.. 2017.03; 484 (3): 636-641. ( PubMed , DOI )

  21. Toru Nakata, Hiromichi Shimizu, Sayaka Nagata, Go Ito, Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Reiko Kuno, Sho Anzai, Tatsuro Murano, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe, Ryuichi Okamoto: Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine. Data Brief. 2017.02; 10 551-556. ( PubMed , DOI )

  22. Toru Nakata, Hiromichi Shimizu, Sayaka Nagata, Go Ito, Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Reiko Kuno, Sho Anzai, Tatsuro Murano, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe, Ryuichi Okamoto: Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors. Biochem. Biophys. Res. Commun.. 2017.01; 482 (4): 1296-1303. ( PubMed , DOI )

  23. Miyako Murakawa, Yasuhiro Asahina, Hiroko Nagata, Mina Nakagawa, Sei Kakinuma, Sayuri Nitta, Fukiko Kawai-Kitahata, Satoshi Otani, Shun Kaneko, Masato Miyoshi, Tomoyuki Tsunoda, Yu Asano, Ayako Sato, Yasuhiro Itsui, Seishin Azuma, Toshihiko Nouchi, Yohei Furumoto, Tooru Asano, Yoshimichi Chuganji, Shuji Tohda, Mamoru Watanabe: ITPA gene variation and ribavirin-induced anemia in patients with genotype 2 chronic hepatitis C treated with sofosbuvir plus ribavirin. Hepatol. Res.. 2017.01; ( PubMed , DOI )

  1. Miyako Murakawa, Yasuhiro Asahina, Fukiko Kawai-Kitahata, Mina Nakagawa, Sayuri Nitta, Satoshi Otani, Hiroko Nagata, Shun Kaneko, Yu Asano, Tomoyuki Tsunoda, Masato Miyoshi, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Yasuhito Tanaka, Sayuki Iijima, Kaoru Tsuchiya, Namiki Izumi, Shuji Tohda, Mamoru Watanabe: Hepatic IFNL4 expression is associated with non-response to interferon-based therapy through the regulation of basal interferon-stimulated gene expression in chronic hepatitis C patients. [Epub ahead of print] J. Med. Virol.. 2016.12; ( PubMed , DOI )

  2. Ryuichi Okamoto, Mamoru Watanabe: Functional relevance of intestinal epithelial cells in inflammatory bowel disease. Nihon Rinsho Meneki Gakkai Kaishi. 2016.11; 39 (6): 522-527. ( PubMed , DOI )

  3. Hitomi Takada, Kaoru Tsuchiya, Yutaka Yasui, Natsuko Nakakuki, Nobuharu Tamaki, Shoko Suzuki, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Masayuki Kurosaki, Yasuhiro Asahina, Nobuyuki Enomoto, Namiki Izumi: Irregular vascular pattern by contrast-enhanced ultrasonography and high serum Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein level predict poor outcome after successful radiofrequency ablation in patients with early-stage hepatocellular carcinoma. Cancer Med. 2016.11; 5 (11): 3111-3120. ( PubMed , DOI )

  4. Masanori Kobayashi, Shigeru Oshima, Chiaki Maeyashiki, Yoichi Nibe, Kana Otsubo, Yu Matsuzawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe: The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development. Sci Rep. 2016.11; 6 36780. ( PubMed , DOI )

  5. Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Toru Nakata, Tatsuro Murano, Go Ito, Hiromichi Shimizu, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Akihiro Araki, Kazuo Ohtsuka, Ryuichi Okamoto, Mamoru Watanabe: PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells. Sci Rep. 2016.11; 6 36795. ( PubMed , DOI )

  6. Sayuri Nitta, Yasuhiro Asahina, Mami Matsuda, Norie Yamada, Ryuichi Sugiyama, Takahiro Masaki, Ryosuke Suzuki, Nobuyuki Kato, Mamoru Watanabe, Takaji Wakita, Takanobu Kato: Effects of Resistance-Associated NS5A Mutations in Hepatitis C Virus on Viral Production and Susceptibility to Antiviral Reagents. Sci Rep. 2016.10; 6 34652. ( PubMed , DOI )

  7. Masato Miyoshi, Sei Kakinuma, Yoko Tanabe, Koji Ishii, Tian-Cheng Li, Takaji Wakita, Yukio Tsuura, Hideki Watanabe, Yasuhiro Asahina, Mamoru Watanabe, Takaaki Ikeda: Chronic Hepatitis E Infection in a Persistently Immunosuppressed Patient Unable to Be Eliminated after Ribavirin Therapy. Intern. Med. 2016.10; 55 (19): 2811-2817. ( PubMed , DOI )

  8. Miyoshi Masato, Kakinuma Sei, Tanabe Yoko, Ishii Koji, Li Tian-Cheng, Wakita Takaji, Tsuura Yukio, Watanabe Hideki, Asahina Yasuhiro, Watanabe Mamoru, Ikeda Takaaki: 恒常的免疫抑制患者における慢性E型肝炎感染はリバビリン療法後に排除することができない(Chronic Hepatitis E Infection in a Persistently Immunosuppressed Patient Unable to Be Eliminated after Ribavirin Therapy) Internal Medicine. 2016.10; 55 (19): 2811-2817. ( ichushi )

  9. Jun Itakura, Masayuki Kurosaki, Chitomi Hasebe, Yukio Osaki, Kouji Joko, Hitoshi Yagisawa, Shinya Sakita, Hiroaki Okushin, Takashi Satou, Hiroyuki Hisai, Takehiko Abe, Keiji Tsuji, Takashi Tamada, Haruhiko Kobashi, Akeri Mitsuda, Yasushi Ide, Chikara Ogawa, Syotaro Tsuruta, Kouichi Takaguchi, Miyako Murakawa, Yasuhiro Asahina, Nobuyuki Enomoto, Namiki Izumi: Complex Pattern of Resistance-Associated Substitutions of Hepatitis C Virus after Daclatasvir/Asunaprevir Treatment Failure. PLoS ONE. 2016.10; 11 (10): e0165339. ( PubMed , DOI )

  10. Fumio Goto, Sei Kakinuma, Masato Miyoshi, Tomoyuki Tsunoda, Shun Kaneko, Ayako Sato, Yu Asano, Satoshi Otani, Seishin Azuma, Hiroko Nagata, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Mina Nakagawa, Yasuhiro Asahina, Mamoru Watanabe: Bone morphogenetic protein-4 modulates proliferation and terminal differentiation of fetal hepatic stem/progenitor cells. Hepatol. Res. 2016.09; 47 (9): 941-952. ( PubMed , DOI )

  11. Ryuichi Okamoto, Mariko Negi, Syohei Tomii, Yoshinobu Eishi, Mamoru Watanabe: Diagnosis and treatment of microscopic colitis. Clin J Gastroenterol. 2016.08; 9 (4): 169-174. ( PubMed , DOI )

  12. Taichi Matsumoto, Wakana Mochizuki, Yoichi Nibe, Shintaro Akiyama, Yuka Matsumoto, Kengo Nozaki, Masayoshi Fukuda, Ayumi Hayashi, Tomohiro Mizutani, Shigeru Oshima, Mamoru Watanabe, Tetsuya Nakamura: Retinol Promotes In Vitro Growth of Proximal Colon Organoids through a Retinoic Acid-Independent Mechanism. PLoS ONE. 2016.08; 11 (8): e0162049. ( PubMed , DOI )

  13. Hiroko Nagata, Mina Nakagawa, Yuki Nishimura-Sakurai, Yu Asano, Tomoyuki Tsunoda, Masato Miyoshi, Shun Kaneko, Fumio Goto, Satoshi Otani, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Naoko Tojo, Shuji Tohda, Yasuhiro Asahina, Mamoru Watanabe, : Serial measurement of Wisteria floribunda agglutinin positive Mac-2-binding protein is useful for predicting liver fibrosis and the development of hepatocellular carcinoma in chronic hepatitis C patients treated with IFN-based and IFN-free therapy.[Epub ahead of print] Hepatol Int. 2016.07; ( PubMed , DOI )

  14. Shun Kaneko, Sei Kakinuma, Yasuhiro Asahina, Akihide Kamiya, Masato Miyoshi, Tomoyuki Tsunoda, Sayuri Nitta, Yu Asano, Hiroko Nagata, Satoshi Otani, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Hiromitsu Nakauchi, Hironori Nishitsuji, Saneyuki Ujino, Kunitada Shimotohno, Masashi Iwamoto, Koichi Watashi, Takaji Wakita, Mamoru Watanabe: Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus. Sci Rep. 2016.07; 6 29358. ( PubMed , DOI )

  15. Ryohei Hayashi, Kiichiro Tsuchiya, Keita Fukushima, Nobukatsu Horita, Shuji Hibiya, Keisuke Kitagaki, Mariko Negi, Eisaku Itoh, Takumi Akashi, Yoshinobu Eishi, Eriko Okada, Akihiro Araki, Kazuo Ohtsuka, Shinji Fukuda, Hiroshi Ohno, Ryuichi Okamoto, Tetsuya Nakamura, Shinji Tanaka, Kazuaki Chayama, Mamoru Watanabe: Reduced Human α-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease. Inflamm. Bowel Dis.. 2016.05; 22 (5): 1119-1128. ( PubMed , DOI )

  16. Ryuichi Okamoto, Mamoru Watanabe: Investigating cell therapy for inflammatory bowel disease. Expert Opin Biol Ther. 2016.04; 1-9. ( PubMed , DOI )

  17. Ana M. Wielandt, Cynthia Villarroel, Claudia Hurtado, Kento Inada, Hiroshi Kawachi, Daniela Simian, Maria T. Vial, Marcela Figueroa, Magdalena Castro, Udo Kronberg, Francisco Lopez-Kostner: Expression levels of orexin receptor 1 in different stages of colorectal cancer Cancer Research. 2016.04; 76 (14_Supplement): 5167. ( DOI )

  18. Seishin Azuma, Yasuhiro Asahina, Yuki Nishimura-Sakurai, Sei Kakinuma, Shun Kaneko, Hiroko Nagata, Fumio Goto, Satoshi Ootani, Fukiko Kawai-Kitahata, Miki Taniguchi, Miyako Murakawa, Takako Watanabe, Megumi Tasaka-Fujita, Yasuhiro Itsui, Mina Nakagawa, Mamoru Watanabe: Efficacy of additional radiofrequency ablation after transcatheter arterial chemoembolization for intermediate hepatocellular carcinoma. Hepatol. Res.. 2016.04; 46 (4): 312-319. ( PubMed , DOI )

  19. Miki Taniguchi, Megumi Tasaka-Fujita, Mina Nakagawa, Takako Watanabe, Fukiko Kawai-Kitahata, Satoshi Otani, Fumio Goto, Hiroko Nagata, Shun Kaneko, Sayuri Nitta, Miyako Murakawa, Yuki Nishimura-Sakurai, Seishin Azuma, Yasuhiro Itsui, Kenichi Mori, Shintaro Yagi, Sei Kakinuma, Yasuhiro Asahina, Mamoru Watanabe: Evaluation of Interferon Resistance in Newly Established Genotype 1b Hepatitis C Virus Cell Culture System. J Clin Transl Hepatol. 2016.03; 4 (1): 5-11. ( PubMed , DOI )

  20. Kengo Nozaki, Wakana Mochizuki, Yuka Matsumoto, Taichi Matsumoto, Masayoshi Fukuda, Tomohiro Mizutani, Mamoru Watanabe, Tetsuya Nakamura: Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes. J. Gastroenterol. 2016.03; 51 (3): 206-213. ( PubMed , DOI )

  21. Yasuhiro Asahina, Namiki Izumi, Kumada Hiromitsu, Masayuki Kurosaki, Kazuhiko Koike, Fumitaka Suzuki, Hajime Takikawa, Atsushi Tanaka, Eiji Tanaka, Yasuhito Tanaka, Hirohito Tsubouchi, Norio Hayashi, Naoki Hiramatsu, Hiroshi Yotsuyanagi: JSH Guidelines for the Management of Hepatitis C Virus Infection: A 2016 update for genotype 1 and 2. Hepatol. Res. 2016.02; 46 (2): 129-165. ( PubMed , DOI )

  22. Satoshi Otani, Sei Kakinuma, Akihide Kamiya, Fumio Goto, Shun Kaneko, Masato Miyoshi, Tomoyuki Tsunoda, Yu Asano, Fukiko Kawai-Kitahata, Sayuri Nitta, Toru Nakata, Ryuichi Okamoto, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Yasuhiro Asahina, Tomoyuki Yamaguchi, Naohiko Koshikawa, Motoharu Seiki, Hiromitsu Nakauchi, Mamoru Watanabe: Matrix metalloproteinase-14 mediates formation of bile ducts and hepatic maturation of fetal hepatic progenitor cells. Biochem. Biophys. Res. Commun.. 2016.01; 469 (4): 1062-1068. ( PubMed , DOI )

  23. Yasuhiro Asahina, Mamoru Watanabe: Need for appropriate programs for prevention of hepatitis B infection: Lessons from the latest nationwide survey in Japan. J. Gastroenterol. Hepatol. 2016.01; 31 (1): 12-13. ( PubMed , DOI )

  24. Ryuichi Okamoto, Mamoru Watanabe: Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease. J. Gastroenterol. 2016.01; 51 (1): 11-21. ( PubMed , DOI )

  1. Megumi Tasaka-Fujita, Nao Sugiyama, Wonseok Kang, Takahiro Masaki, Asako Murayama, Norie Yamada, Ryuichi Sugiyama, Senko Tsukuda, Koichi Watashi, Yasuhiro Asahina, Naoya Sakamoto, Takaji Wakita, Eui-Cheol Shin, Takanobu Kato: Corrigendum: Amino Acid Polymorphisms in Hepatitis C Virus Core Affect Infectious Virus Production and Major Histocompatibility Complex Class I Molecule Expression. Sci Rep. 2015.12; 5 17208. ( PubMed , DOI )

  2. Fukiko Kawai-Kitahata, Yasuhiro Asahina, Shinji Tanaka, Sei Kakinuma, Miyako Murakawa, Sayuri Nitta, Takako Watanabe, Satoshi Otani, Miki Taniguchi, Fumio Goto, Hiroko Nagata, Shun Kaneko, Megumi Tasaka-Fujita, Yuki Nishimura-Sakurai, Seishin Azuma, Yasuhiro Itsui, Mina Nakagawa, Minoru Tanabe, Shinichi Takano, Mitsuharu Fukasawa, Minoru Sakamoto, Shinya Maekawa, Nobuyuki Enomoto, Mamoru Watanabe: Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features. J. Gastroenterol. 2015.11; ( PubMed , DOI )

  3. Megumi Tasaka-Fujita, Nao Sugiyama, Wonseok Kang, Takahiro Masaski, Asako Murayama, Norie Yamada, Ryuichi Sugiyama, Senko Tsukuda, Koichi Watashi, Yasuhiro Asahina, Naoya Sakamoto, Takaji Wakita, Eui-Cheol Shin, Takanobu Kato: Amino acid polymorphisms in hepatitis C virus core affect infectious virus production and major histocompatibility complex class I molecule expression. Sci Rep. 2015.09; 5 13994. ( PubMed , DOI )

  4. Nobuharu Tamaki, Masayuki Kurosaki, Mayu Higuchi, Hitomi Takada, Natsuko Nakakuki, Yutaka Yasui, Shoko Suzuki, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Shintaro Ogawa, Yasuhito Tanaka, Yasuhiro Asahina, Namiki Izumi: Genetic polymorphisms of IL28B and PNPLA3 are predictive for HCV related rapid fibrosis progression and identify patients who require urgent antiviral treatment with new regimens. PLoS ONE. 2015.09; 10 (9): e0137351. ( PubMed , DOI )

  5. Ryuichi Okamoto, Mamoru Watanabe: Perspectives for Regenerative Medicine in the Treatment of Inflammatory Bowel Diseases. Digestion. 2015.07; 92 (2): 73-77. ( PubMed , DOI )

  6. Yu Matsuzawa, Shigeru Oshima, Masahiro Takahara, Chiaki Maeyashiki, Yasuhiro Nemoto, Masanori Kobayashi, Yoichi Nibe, Kengo Nozaki, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Averil Ma, Mamoru Watanabe: TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy. Autophagy. 2015.06; 11 (7): 1052-1062. ( PubMed , DOI )

  7. Miyako Murakawa, Yasuhiro Asahina, Mina Nakagawa, Naoya Sakamoto, Sayuri Nitta, Akiko Kusano-Kitazume, Takako Watanabe, Fukiko Kawai-Kitahata, Satoshi Otani, Miki Taniguchi, Fumio Goto, Yuki Nishimura-Sakurai, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Mamoru Watanabe: Impaired induction of interleukin 28B and expression of interferon λ 4 associated with nonresponse to interferon-based therapy in chronic hepatitis C. J. Gastroenterol. Hepatol. 2015.06; 30 (6): 1075-1084. ( PubMed , DOI )

  8. Keita Fukushima, Kiichiro Tsuchiya, Yoshihito Kano, Nobukatsu Horita, Shuji Hibiya, Ryohei Hayashi, Keisuke Kitagaki, Mariko Negi, Eisaku Itoh, Takumi Akashi, Yoshinobu Eishi, Shigeru Oshima, Takashi Nagaishi, Okamoto Ryuichi, Tetsuya Nakamura, Mamoru Watanabe: Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line. Cancer Sci.. 2015.05; ( PubMed , DOI )

  9. Yu Matsuzawa, Shigeru Oshima, Yoichi Nibe, Masanori Kobayashi, Chiaki Maeyashiki, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe: RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62. Biochem. Biophys. Res. Commun. 2015.01; 456 (1): 298-304. ( PubMed , DOI )

  1. Nobutoshi Komatsu, Utaroh Motosugi, Shinya Maekawa, Kuniaki Shindo, Minoru Sakamoto, Mitsuaki Sato, Akihisa Tatsumi, Mika Miura, Fumitake Amemiya, Yasuhiro Nakayama, Taisuke Inoue, Mitsuharu Fukasawa, Tomoyoshi Uetake, Masahiko Ohtaka, Tadashi Sato, Yasuhiro Asahina, Masayuki Kurosaki, Namiki Izumi, Tomoaki Ichikawa, Tsutomu Araki, Nobuyuki Enomoto: Hepatocellular carcinoma risk assessment using gadoxetic acid-enhanced hepatocyte phase magnetic resonance imaging. Hepatol Res. 2014.12; 44 (13): 1339-1346. ( PubMed , DOI )

  2. Nobuharu Tamaki, Masayuki Kurosaki, Shuya Matsuda, Masaru Muraoka, Yutaka Yasui, Shoko Suzuki, Takanori Hosokawa, Ken Ueda, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Yasuhiro Asahina, Namiki Izumi: Non-invasive prediction of hepatocellular carcinoma development using serum fibrosis marker in chronic hepatitis C patients. J. Gastroenterol. 2014.11; 49 (11): 1495-1503. ( PubMed , DOI )

  3. Nobukatsu Horita, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Shuji Hibiya, Masayoshi Fukuda, Yoshihito Kano, Tomohiro Mizutani, Yasuhiro Nemoto, Shiro Yui, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe: Fluorescent labelling of intestinal epithelial cells reveals independent long-lived intestinal stem cells in a crypt. Biochem. Biophys. Res. Commun. 2014.10; 454 (4): 493-499. ( PubMed , DOI )

  4. Yoshihito Kano, Sei Kakinuma, Fumio Goto, Seishin Azuma, Yuki Nishimura-Sakurai, Yasuhiro Itsui , Mina Nakagawa, Atsushi Kudo, Minoru Tanabe, Susumu Kirimura, Tomonori Amano, Takashi Ito , Takumi Akashi, Yasuhiro Asahina, Mamoru Watanabe: Primary Hepatic Neuroendocrine Carcinoma with a Cholangiocellular Carcinoma Component in One Nodule. Clinical Journal of Gastroenterology. 2014.10; 7 449-454.

  5. Yoshihito Kano, Sei Kakinuma, Fumio Goto, Seishin Azuma, Yuki Nishimura-Sakurai, Yasuhiro Itsui, Mina Nakagawa, Atsushi Kudo, Minoru Tanabe, Susumu Kirimura, Tomonori Amano, Takashi Ito, Takumi Akashi, Yasuhiro Asahina, Mamoru Watanabe: Primary hepatic neuroendocrine carcinoma with a cholangiocellular carcinoma component in one nodule. Clin J Gastroenterol. 2014.10; 7 (5): 449-454. ( PubMed , DOI )

  6. Goki Suda, Yoshiya Yamamoto, Astushi Nagasaka, Ken Furuya, Mineo Kudo, Yoshimichi Chuganji, Yoko Tsukuda, Seiji Tsunematsu, Fumiyuki Sato, Katsumi Terasita, Masato Nakai, Hiromasa Horimoto, Takuya Sho, Mitsuteru Natsuizaka, Kouji Ogawa, Shunsuke Ohnishi, Makoto Chuma, Yasuyuki Fujita, Riichiro Abe, Miki Taniguchi, Mina Nakagawa, Yasuhiro Asahina, Naoya Sakamoto, : Serum granulysin levels as a predictor of serious telaprevir-induced dermatological reactions. Hepatol Res.. 2014.09; ( PubMed , DOI )

  7. Kaoru Tsuchiya, Yasuhiro Asahina, Masayuki Kurosaki, Nobuyuki Enomoto, Namiki Izumi: Reply: To PMID 24734314. Liver Transpl. 2014.09; 20 (9): 1152. ( PubMed , DOI )

  8. Yasuhiro Asahina, Kaoru Tsuchiya, Namiki Izumi: Reply: To PMID 23564522. Hepatology. 2014.08; 60 (2): 764. ( PubMed , DOI )

  9. Yasuhiro Iizuka, Hideki Sakai, Konomi Kobayashi, Kazue Iizuka, Eri Ito, Nahoko Mochizuki, Yasuhiro Asahina, Mamoru Watanabe: A case of chronic hepatitis B managed with continued adefovir despite treatment-related Fanconi syndrome and osteomalacia. Nihon Shokakibyo Gakkai Zasshi. 2014.08; 111 (8): 1618-1623. ( PubMed )

  10. Masayoshi Fukuda, Tomohiro Mizutani, Wakana Mochizuki, Taichi Matsumoto, Kengo Nozaki, Yuriko Sakamaki, Shizuko Ichinose, Yukinori Okada, Toshihiro Tanaka, Mamoru Watanabe, Tetsuya Nakamura: Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon. Genes Dev. 2014.08; 28 (16): 1752-1757. ( PubMed , DOI )

  11. Nobuharu Tamaki, Masayuki Kurosaki, Shuya Matsuda, Toru Nakata, Masaru Muraoka, Yuichiro Suzuki, Yutaka Yasui, Shoko Suzuki, Takanori Hosokawa, Takashi Nishimura, Ken Ueda, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Kotaro Matsunaga, Kazuhiro Taki, Yasuhiro Asahina, Namiki Izumi: Prospective comparison of real-time tissue elastography and serum fibrosis markers for the estimation of liver fibrosis in chronic hepatitis C patients. Hepatol Res. 2014.07; 44 (7): 720-727. ( PubMed , DOI )

  12. Yasuhiro Asahina, Kaoru Tsuchiya, Takashi Nishimura, Masaru Muraoka, Yuichiro Suzuki, Nobuharu Tamaki, Yutaka Yasui, Takanori Hosokawa, Ken Ueda, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Masayuki Kurosaki, Nobuyuki Enomoto, Mina Nakagawa, Sei Kakinuma, Mamoru Watanabe, Namiki Izumi: Genetic variation near interleukin 28B and the risk of hepatocellular carcinoma in patients with chronic hepatitis C. J. Gastroenterol. 2014.07; 49 (7): 1152-1162. ( PubMed , DOI )

  13. Hiromichi Shimizu, Ryuichi Okamoto, Go Ito, Satoru Fujii, Toru Nakata, Kohei Suzuki, Tatsuro Murano, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe: Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine. PeerJ. 2014.05; 2 (1): e370. ( PubMed , DOI )

  14. Hiroyuki Nakanishi, Masayuki Kurosaki, Kaoru Nakanishi, Kaoru Tsuchiya, Takamasa Noda, Nobuharu Tamaki, Yutaka Yasui, Takanori Hosokawa, Ken Ueda, Jun Itakura, Kimitaka Anami, Yasuhiro Asahina, Nobuyuki Enomoto, Teruhiko Higuchi, Namiki Izumi: Impaired brain activity in cirrhotic patients with minimal hepatic encephalopathy: Evaluation by near-infrared spectroscopy. Hepatol Res. 2014.03; 44 (3): 319-326. ( PubMed , DOI )

  15. Kaoru Tsuchiya, Yasuhiro Asahina, Nobuharu Tamaki, Yutaka Yasui, Takanori Hosokawa, Ken Ueda, Hiroyuki Nakanishi, Jun Itakura, Masayuki Kurosaki, Nobuyuki Enomoto, Namiki Izumi: Risk factors for exceeding the Milan criteria after successful radiofrequency ablation in patients with early-stage hepatocellular carcinoma. Liver Transpl. 2014.03; 20 (3): 291-297. ( PubMed )

  16. Masahiro Suzuki, Takashi Nagaishi, Motomi Yamazaki, Michio Onizawa, Taro Watabe, Yuriko Sakamaki, Shizuko Ichinose, Mamoru Totsuka, Shigeru Oshima, Ryuichi Okamoto, Motoyuki Shimonaka, Hideo Yagita, Tetsuya Nakamura, Mamoru Watanabe: Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis. PLoS ONE. 2014.02; 9 (2): e88369. ( PubMed , DOI )

  17. Nao Nishida, Hiromi Sawai, Koichi Kashiwase, Mutsuhiko Minami, Masaya Sugiyama, Wai-Kay Seto, Man-Fung Yuen, Nawarat Posuwan, Yong Poovorawan, Sang Hoon Ahn, Kwang-Hyub Han, Kentaro Matsuura, Yasuhito Tanaka, Masayuki Kurosaki, Yasuhiro Asahina, Namiki Izumi, Jong-Hon Kang, Shuhei Hige, Tatsuya Ide, Kazuhide Yamamoto, Isao Sakaida, Yoshikazu Murawaki, Yoshito Itoh, Akihiro Tamori, Etsuro Orito, Yoichi Hiasa, Masao Honda, Shuichi Kaneko, Eiji Mita, Kazuyuki Suzuki, Keisuke Hino, Eiji Tanaka, Satoshi Mochida, Masaaki Watanabe, Yuichiro Eguchi, Naohiko Masaki, Kazumoto Murata, Masaaki Korenaga, Yoriko Mawatari, Jun Ohashi, Minae Kawashima, Katsushi Tokunaga, Masashi Mizokami: New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia. PLoS ONE. 2014.02; 9 (2): e86449. ( PubMed , DOI )

  18. Asahina Y, HayashinN, Hiramatsu N, Izumi N, Koike K, Kumada H, Kurosaki M,Oketani M, Suzuki F, Takikawa H, Tanaka A, Tanaka E, Tanaka Y, Tsubouchi H,Yotsuyanagi H: JSH Guidelines for the Management of Hepatitis B Virus Infection. Hepatol Res. 2014.01; 44 Suppl S1 1-58. ( PubMed , DOI )

  19. Kaoru Tsuchiya, Yasuhiro Asahina, Shuya Matsuda, Masaru Muraoka, Toru Nakata, Yuichiro Suzuki, Nobuharu Tamaki, Yutaka Yasui, Shoko Suzuki, Takanori Hosokawa, Takashi Nishimura, Ken Ueda, Teiji Kuzuya, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Masayuki Kurosaki, Nobuyuki Enomoto, Namiki Izumi: Changes in plasma vascular endothelial growth factor at 8 weeks after sorafenib administration as predictors of survival for advanced hepatocellular carcinoma. Cancer. 2014.01; 120 (2): 229-237. ( PubMed , DOI )

  20. Tatsuro Murano, Ryuichi Okamoto, Go Ito, Toru Nakata, Shuji Hibiya, Hiromichi Shimizu, Satoru Fujii, Yoshihito Kano, Tomohiro Mizutani, Shiro Yui, Junko Akiyama-Morio, Yasuhiro Nemoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe: Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells. Biochem. Biophys. Res. Commun. 2014.01; 443 (3): 840-846. ( PubMed , DOI )

  21. Yasui Y, Kudo A, Kurosaki M, Matsuda S, Muraoka M, Tamaki N, Suzuki S, Hosokawa T, Ueda K, Matsunaga K, Nakanishi H, Tsuchiya K, Itakura J, Takahashi Y, Tanaka S, Asahina Y, Enomoto N, Arii S, Izumi N.: Reduced organic anion transporter expression is a risk factor for hepatocellular carcinoma in chronic hepatitis C patients: a propensity score matching study. Oncology. 2014.01; 86 (1): 53-62. ( PubMed , DOI )

  1. Okamoto R, Nagaori T, Watanabe M: Prespectives for IBD in Japan. AGA Perspectives. 2013.12; 9 (2): 18-19.

  2. Masahiro Takahara, Yasuhiro Nemoto, Shigeru Oshima, Yu Matsuzawa, Takanori Kanai, Ryuichi Okamoto, Kiichiro Tsuchiyaa, Tetsuy Nakamura, Kazuhide Yamamoto, Mamoru Watanabe.: IL-7 promotes long-term in vitro survival of unique long-lived memory subset generated from mucosal effector memory CD4+ T cells in chronic colitis mice. Immunol Lett. 2013.11; 156 (1-2): 82-93. ( PubMed , DOI )

  3. Go Ito, Ryuichi Okamoto, Tatsuro Murano, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Tomohiro Mizutani, Shiro Yui, Junko Akiyama-Morio, Yasuhiro Nemoto, Eriko Okada, Akihiro Araki, Kazuo Ohtsuka, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe: Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cells. PLoS ONE. 2013.11; 8 (11): e79693. ( PubMed , DOI )

  4. Yasuhiro Asahina, Kaoru Tsuchiya, Takashi Nishimura, Masaru Muraoka, Yuichiro Suzuki, Nobuharu Tamaki, Yutaka Yasui, Takanori Hosokawa, Ken Ueda, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Masayuki Kurosaki, Nobuyuki Enomoto, Mina Nakagawa, Sei Kakinuma, Mamoru Watanabe, Namiki Izumi: α-fetoprotein levels after interferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C. Hepatology. 2013.10; 58 (4): 1253-1262. ( PubMed , DOI )

  5. Yasuhiro Asahina, Mina Nakagawa, Sei Kakinuma, Mamoru Watanabe: Polymorphism Near the Interleukin-28B Gene and Anti-Hepatitis C Viral Response. J Clin Transl Hepatol. 2013.09; 1 (1): 39-44. ( PubMed , DOI )

  6. Yasuhiro Nemoto, Takanori Kanai, Masahiro Takahara, Shigeru Oshima, Tetsuya Nakamura, Ryuichi Okamoto, Kiichiro Tsuchiya, and Mamoru Watanabe.: Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells. Gut. 2013.08; 62 (8): 1142-1152. ( PubMed , DOI )

  7. Kei Kiyohashi, Sei Kakinuma, Akihide Kamiya, Naoya Sakamoto, Sayuri Nitta, Hideto Yamanaka, Kouhei Yoshino, Junko Fujiki, Miyako Murakawa, Akiko Kusano-Kitazume, Hiromichi Shimizu, Ryuichi Okamoto, Seishin Azuma, Mina Nakagawa, Yasuhiro Asahina, Naoki Tanimizu, Akira Kikuchi, Hiromitsu Nakauchi, Mamoru Watanabe: Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells in mice. Hepatology. 2013.06; 57 (6): 2502-2513. ( PubMed , DOI )

  8. Yasuhiro Nemoto, Takanori Kanai, Masahiro Takahara, Shigeru Oshima, Ryuichi Okamoto, Kiichiro Tsuchiya, Satoshi Matsumoto, Mamoru Watanabe: Th1/Th17-mediated interstitial pneumonia in chronic colitis mice independent of intestinal microbiota. J. Immunol.. 2013.06; 190 (12): 6616-6625. ( PubMed , DOI )

  9. Namiki Izumi, Yasuhiro Asahina, Masayuki Kurosaki, Gotaro Yamada, Tsutomu Kawai, Eiji Kajiwara, Yukishige Okamura, Takayuki Takeuchi, Osamu Yokosuka, Kazuya Kariyama, Joji Toyoda, Mie Inao, Eiji Tanaka, Hisataka Moriwaki, Hiroshi Adachi, Shinji Katsushima, Masatoshi Kudo, Kouichi Takaguchi, Yoichi Hiasa, Kazuaki Chayama, Hiroshi Yatsuhashi, Makoto Oketani, Hiromitsu Kumada: Inhibition of hepatocellular carcinoma by PegIFNα-2a in patients with chronic hepatitis C: a nationwide multicenter cooperative study. J Gastroenterol. 2013.03; 48 (3): 382-390. ( PubMed , DOI )

  10. Yoshihito Kano, Kiichiro Tsuchiya, Xiu Zheng, Nobukatsu Horita, Keita Fukushima, Shuji Hibiya, Yuhki Yamauchi, Tatsunori Nishimura, Kunihiko Hinohara, Noriko Gotoh, Shinji Suzuki, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe: The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein. Biochem. Biophys. Res. Commun. 2013.03; 432 (1): 175-181. ( PubMed , DOI )

  11. Sayuri Nitta, Naoya Sakamoto, Mina Nakagawa, Sei Kakinuma, Kako Mishima, Akiko Kusano-Kitazume, Kei Kiyohashi, Miyako Murakawa, Yuki Nishimura-Sakurai, Seishin Azuma, Megumi Tasaka-Fujita, Yasuhiro Asahina, Mitsutoshi Yoneyama, Takashi Fujita, Mamoru Watanabe: Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity. Hepatology. 2013.01; 57 (1): 46-58. ( PubMed , DOI )

  12. Akira Sato, Michio Sata, Kenji Ikeda, Takashi Kumada, Namiki Izumi, Yasuhiro Asahina, Yukio Osaki, Kazuaki Chayama, Shuichi Kaneko, Akito Sakai, Morikazu Onji, Yoichi Hiasa, Takumi Omura, Itaru Ozeki, Osamu Yokosuka, Shuichiro Shiina, Mariko Itsubo, Shuhei Nishiguchi, Katsuharu Hirano, Tatsuya Ide, Shotaro Sakisaka, Takahiro Yamasaki, Isao Hidaka, Masatoshi Tanaka, Soo Ryang Kim, Takafumi Ichida: Clinical characteristics of patients who developed hepatocellular carcinoma after hepatitis C virus eradication with interferon therapy: current status in Japan. Intern Med. 2013; 52 (24): 2701-2706. ( PubMed , DOI )

  1. Yuichi Ono, Takanori Kanai, Tomohisa Sujino, Yasuhiro Nemoto, Yasumasa Kanai, Yohei Mikami, Atsushi Hayashi, Atsuhiro Matsumoto, Hiromasa Takaishi, Haruhiko Ogata, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Mamoru Watanabe, Toshifumi Hibi: T-helper 17 and interleukin-17-producing lymphoid tissue inducer-like cells make different contributions to colitis in mice. Gastroenterology. 2012.11; 143 (5): 1288-1297. ( PubMed , DOI )

  2. Akihiro Araki, Kiichiro Tsuchiya, Shigeru Oshima, Eriko Okada, Shinji Suzuki, Junko Morio Akiyama, Toshimitsu Fujii, Ryuichi Okamoto, Mamoru Watanabe: Endoscopic ultrasound with double-balloon endoscopy for the diagnosis of inverted Meckel's diverticulum: a case report. J Med Case Rep. 2012.09; 6 (1): 328. ( PubMed , DOI )

  3. Hiromi Sawai, Nao Nishida, Hamdi Mbarek, Koichi Matsuda, Yoriko Mawatari, Megumi Yamaoka, Shuhei Hige, Jong-Hon Kang, Koichi Abe, Satoshi Mochida, Masaaki Watanabe, Masayuki Kurosaki, Yasuhiro Asahina, Namiki Izumi, Masao Honda, Shuichi Kaneko, Eiji Tanaka, Kentaro Matsuura, Yoshito Itoh, Eiji Mita, Masaaki Korenaga, Keisuke Hino, Yoshikazu Murawaki, Yoichi Hiasa, Tatsuya Ide, Kiyoaki Ito, Masaya Sugiyama, Sang Hoon Ahn, Kwang-Hyub Han, Jun Yong Park, Man-Fung Yuen, Yusuke Nakamura, Yasuhito Tanaka, Masashi Mizokami, Katsushi Tokunaga: No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations. BMC Med Genet. 2012.06; 13 47. ( PubMed , DOI )

  4. Hiroko Shindo, Shinya Maekawa, Kazuki Komase, Ryota Sueki, Mika Miura, Makoto Kadokura, Kuniaki Shindo, Fumitake Amemiya, Takatoshi Kitamura, Yasuhiro Nakayama, Taisuke Inoue, Minoru Sakamoto, Shun-Ichi Okada, Yasuhiro Asahina, Namiki Izumi, Masao Honda, Shuichi Kaneko, Nobuyuki Enomoto: Characterization of naturally occurring protease inhibitor-resistance mutations in genotype 1b hepatitis C virus patients. Hepatol Int. 2012.04; 6 (2): 482-490. ( PubMed , DOI )

  5. Kusano-Kitazume A, Sakamoto N, Okuno Y, Sekine-Osajima Y, Nakagawa M, Kakinuma S, Kiyohashi K, Nitta S, Murakawa M, Azuma S, Nishimura-Sakurai Y, Hagiwara M, Watanabe M: Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication. Antimicrob Agents Chemother. 2012.03; 56 (3): 1315-1323. ( PubMed , DOI )

  6. Yui S, Nakamura T, Sato T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, Nagaishi T, Okamoto R, Tsuchiya K, Clevers H, Watanabe M.: Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell. Nat Med. 2012.03;

  7. Tomohiro Mizutani, Tetsuya Nakamura, Ryo Morikawa, Masayoshi Fukuda, Wakana Mochizuki, Yuhki Yamauchi, Kengo Nozaki, Shiro Yui, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Mamoru Watanabe: Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro. Biochem. Biophys. Res. Commun.. 2012.03; 419 (2): 238-243. ( PubMed , DOI )

  8. Shiro Yui, Tetsuya Nakamura, Toshiro Sato, Yasuhiro Nemoto, Tomohiro Mizutani, Xiu Zheng, Shizuko Ichinose, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Hans Clevers, Mamoru Watanabe: Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell. Nat. Med.. 2012.03; 18 (4): 618-623. ( PubMed , DOI )

  9. Osamu Yamaji, Takashi Nagaishi, Teruji Totsuka, Michio Onizawa, Masahiro Suzuki, Naoto Tsuge, Atsuhiko Hasegawa, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Hisashi Arase, Takanori Kanai, Mamoru Watanabe: The development of colitogenic CD4(+) T cells is regulated by IL-7 in collaboration with NK cell function in a murine model of colitis. J. Immunol.. 2012.03; 188 (6): 2524-2536. ( PubMed , DOI )

  10. Yasuhiro Asahina, Kaoru Tsuchiya, Masaru Muraoka, Keisuke Tanaka, Yuichiro Suzuki, Nobuharu Tamaki, Yoshihide Hoshioka, Yutaka Yasui, Tomoji Katoh, Takanori Hosokawa, Ken Ueda, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Masayuki Kurosaki, Nobuyuki Enomoto, Sayuri Nitta, Naoya Sakamoto, Namiki Izumi: Association of gene expression involving innate immunity and genetic variation in interleukin 28B with antiviral response. Hepatology. 2012.01; 55 (1): 20-29. ( PubMed , DOI )

  11. Nao Nishida, Hiromi Sawai, Kentaro Matsuura, Masaya Sugiyama, Sang Hoon Ahn, Jun Yong Park, Shuhei Hige, Jong-Hon Kang, Kazuyuki Suzuki, Masayuki Kurosaki, Yasuhiro Asahina, Satoshi Mochida, Masaaki Watanabe, Eiji Tanaka, Masao Honda, Shuichi Kaneko, Etsuro Orito, Yoshito Itoh, Eiji Mita, Akihiro Tamori, Yoshikazu Murawaki, Yoichi Hiasa, Isao Sakaida, Masaaki Korenaga, Keisuke Hino, Tatsuya Ide, Minae Kawashima, Yoriko Mawatari, Megumi Sageshima, Yuko Ogasawara, Asako Koike, Namiki Izumi, Kwang-Hyub Han, Yasuhito Tanaka, Katsushi Tokunaga, Masashi Mizokami: Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean. PLoS One. 2012; 7 (6): e39175. ( PubMed , DOI )

  1. Nemoto Y, Kanai T, Shinohara T, Ito T, Nakamura T, Okamoto R, Tsuchiya K, Lipp M, Eishi Y, Watanabe M.: Luminal CD4⁺ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation. Gastroenterology. 2011.12;

  2. Yasuhiro Nemoto, Takanori Kanai, Tamako Shinohara, Takashi Ito, Tetsuya Nakamura, Ryuichi Okamoto, Kiichiro Tsuchiya, Martin Lipp, Yoshinobu Eishi, Mamoru Watanabe: Luminal CD4⁺ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation. Gastroenterology. 2011.12; 141 (6): 2130-2139.e11. ( PubMed , DOI )

  3. Xiu Zheng, Kiichiro Tsuchiya, Ryuichi Okamoto, Michiko Iwasaki, Yoshihito Kano, Naoya Sakamoto, Tetsuya Nakamura, Mamoru Watanabe: Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis. Inflamm. Bowel Dis.. 2011.11; 17 (11): 2251-2260. ( PubMed , DOI )

  4. Funaoka Y, Sakamoto N, Suda G, Itsui Y, Nakagawa M, Kakinuma S, Watanabe T, Mishima K, Ueyama M, Onozuka I, Nitta S, Kitazume A, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, Watanabe M: Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 91. J Virol. 2011.06; 85 (12): 5986-5994. ( PubMed , DOI )

  5. Jun Itakura, Yasuhiro Asahina, Nobuharu Tamaki, Itsuko Hirayama, Yutaka Yasui, Tomohiro Tanaka, Mitsuaki Sato, Ken Ueda, Teiji Kuzuya, Kaoru Tsuchiya, Hiroyuki Nakanishi, Masayuki Kurosaki, Gretchen S Gabriel, George J Schneider, Namiki Izumi: Changes in hepatitis C viral load during first 14 days can predict the undetectable time point of serum viral load by pegylated interferon and ribavirin therapy. Hepatol Res. 2011.03; 41 (3): 217-224. ( PubMed , DOI )

  6. Sakamoto N, Nakagawa M, Tanaka Y, Sekine-Osajima Y, Ueyama M, Kurosaki M, Nishida N, Tamori A, Nishimura-Sakurai Y, Itsui Y, Azuma S, Kakinuma S, Hige S, Ito Y, Tanaka E, Hiasa Y, Izumi N, Tokunaga K, Mizokami M, Watanabe M: Association of IL28B variants with response to pegylated-interferon alpha plus ribavirin combination therapy reveals intersubgenotypic differences between genotypes 2a and 2b. J Med Virol. 2011.03; 83 871-878. ( PubMed , DOI )

  7. Masayuki Kurosaki, Yasuhito Tanaka, Nao Nishida, Naoya Sakamoto, Nobuyuki Enomoto, Masao Honda, Masaya Sugiyama, Kentaro Matsuura, Fuminaka Sugauchi, Yasuhiro Asahina, Mina Nakagawa, Mamoru Watanabe, Minoru Sakamoto, Shinya Maekawa, Akito Sakai, Shuichi Kaneko, Kiyoaki Ito, Naohiko Masaki, Katsushi Tokunaga, Namiki Izumi, Masashi Mizokami: Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors. J. Hepatol.. 2011.03; 54 (3): 439-448. ( PubMed , DOI )

  8. Yamamoto M, Sakamoto N, Nakamura T, Itsui Y, Nakagawa M, Nishimura-Sakurai Y, Kakinuma S, Azuma S, Tsuchiya K, Kato T, Wakita T, Watanabe M: Studies on virus kinetics using infectious fluorescence-tagged hepatitis C virus cell culture. Hepatol Res. 2011.03; 41 (3): 258-269. ( PubMed , DOI )

  9. Izumi Onozuka, Sei Kakinuma, Akihide Kamiya, Masato Miyoshi, Naoya Sakamoto, Kei Kiyohashi, Takako Watanabe, Yusuke Funaoka, Mayumi Ueyama, Mina Nakagawa, Naohiko Koshikawa, Motoharu Seiki, Hiromitsu Nakauchi, Mamoru Watanabe: Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice. Biochem. Biophys. Res. Commun.. 2011.03; 406 (1): 134-140. ( PubMed , DOI )

  10. Shinohara T*, Nemoto Y*, Kanai T, Kameyama K, Okamoto R, Tsuchiya K, Nakamura T, Totsuka T, Ikuta K, Watanabe M. *equally contributed: Upregulated IL-7 receptor α expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis. J Immunol. 2011.02;

  11. Tamako Shinohara, Yasuhiro Nemoto, Takanori Kanai, Kaori Kameyama, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Teruji Totsuka, Koichi Ikuta, Mamoru Watanabe: Upregulated IL-7 receptor α expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis. J. Immunol.. 2011.02; 186 (4): 2623-2632. ( PubMed , DOI )

  12. Teiji Kuzuya, Yasuhiro Asahina, Kaoru Tsuchiya, Keisuke Tanaka, Yuichiro Suzuki, Takahide Hoshioka, Shinji Tamaki, Tomoji Kato, Yutaka Yasui, Takahiro Hosokawa, Ken Ueda, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Masayuki Kurosaki, Namiki Izumi: Early decrease in α-fetoprotein, but not des-γ-carboxy prothrombin, predicts sorafenib efficacy in patients with advanced hepatocellular carcinoma. Oncology. 2011; 81 (3-4): 251-258. ( PubMed , DOI )

  13. Kaoru Tsuchiya, Mina Komuta, Yutaka Yasui, Nobuharu Tamaki, Takanori Hosokawa, Ken Ueda, Teiji Kuzuya, Jun Itakura, Hiroyuki Nakanishi, Yuka Takahashi, Masayuki Kurosaki, Yasuhiro Asahina, Nobuyuki Enomoto, Michiie Sakamoto, Namiki Izumi: Expression of keratin 19 is related to high recurrence of hepatocellular carcinoma after radiofrequency ablation. Oncology. 2011; 80 (3-4): 278-288. ( PubMed , DOI )

  14. Masayuki Kurosaki, Yasuhito Tanaka, Keisuke Tanaka, Yuichiro Suzuki, Yoshihide Hoshioka, Nobuharu Tamaki, Tomoji Kato, Yutaka Yasui, Takanori Hosokawa, Ken Ueda, Kaoru Tsuchiya, Teiji Kuzuya, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Yasuhiro Asahina, Kentaro Matsuura, Fuminaka Sugauchi, Nobuyuki Enomoto, Nao Nishida, Katsushi Tokunaga, Masashi Mizokami, Namiki Izumi: Relationship between polymorphisms of the inosine triphosphatase gene and anaemia or outcome after treatment with pegylated interferon and ribavirin. Antivir Ther. 2011; 16 (5): 685-694. ( PubMed , DOI )

  15. Ueyama M, Nakagawa M, Sakamoto N, Onozuka I, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Kitazume A, Murakawa M, Nishimura-Sakurai Y, Sekine-Osajima Y, Itsui Y, Azuma S, Kakinuma S, Watanabe M:: Serum interleukin-6 levels correlate with resistance to treatment of chronic hepatitis C infection with pegylated-interferon-α2b plus ribavirin. Antiviral Therapy. 2011; 16 1081-1091. ( PubMed , DOI )

  1. Iwasaki M, Tsuchiya K, Okamoto R, Zheng X, Kano Y, Okamoto E, Okada E, Araki A, Suzuki S, Sakamoto N, Kitagaki K, Akashi T, Eishi Y, Nakamura T, Watanabe M: Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4. J Gastroenterol. 2010.12; ( PubMed , DOI )

  2. Masakazu Nagahori, Sea Bong Hyun, Teruji Totsuka, Ryuichi Okamoto, Erika Kuwahara, Toru Takebayashi, Makoto Naganuma, Mamoru Watanabe: Prevalence of metabolic syndrome is comparable between inflammatory bowel disease patients and the general population. J. Gastroenterol.. 2010.10; 45 (10): 1008-1013. ( PubMed , DOI )

  3. Masayuki Kurosaki, Takanori Hosokawa, Kotaro Matsunaga, Itsuko Hirayama, Tomohiro Tanaka, Mitsuaki Sato, Yutaka Yasui, Nobuharu Tamaki, Ken Ueda, Kaoru Tsuchiya, Teiji Kuzuya, Hiroyuki Nakanishi, June Itakura, Yuka Takahashi, Yasuhiro Asahina, Nobuyuki Enomoto, Namiki Izumi: Hepatic steatosis in chronic hepatitis C is a significant risk factor for developing hepatocellular carcinoma independent of age, sex, obesity, fibrosis stage and response to interferon therapy. Hepatol Res. 2010.09; 40 (9): 870-877. ( PubMed , DOI )

  4. Kameyama K*, Nemoto Y*, Kanai T, Shinohara T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Totsuka T, Hibi T, Watanabe M. *equally contributed: IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitis. Eur J Immunol. 2010.09;

  5. Kaori Kameyama, Yasuhiro Nemoto, Takanori Kanai, Tamako Shinohara, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Naoya Sakamoto, Teruji Totsuka, Toshifumi Hibi, Mamoru Watanabe: IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitis. Eur J Immunol. 2010.09; 40 (9): 2423-2436. ( PubMed , DOI )

  6. Yasuhiro Asahina, Kaoru Tsuchiya, Nobuharu Tamaki, Itsuko Hirayama, Tomohiro Tanaka, Mitsuaki Sato, Yutaka Yasui, Takanori Hosokawa, Ken Ueda, Teiji Kuzuya, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Masayuki Kurosaki, Nobuyuki Enomoto, Namiki Izumi: Effect of aging on risk for hepatocellular carcinoma in chronic hepatitis C virus infection. Hepatology. 2010.08; 52 (2): 518-527. ( PubMed , DOI )

  7. Masayuki Kurosaki, Kotaro Matsunaga, Itsuko Hirayama, Tomohiro Tanaka, Mitsuaki Sato, Yutaka Yasui, Nobuharu Tamaki, Takanori Hosokawa, Ken Ueda, Kaoru Tsuchiya, Hiroyuki Nakanishi, Hiroki Ikeda, Jun Itakura, Yuka Takahashi, Yasuhiro Asahina, Megumu Higaki, Nobuyuki Enomoto, Namiki Izumi: A predictive model of response to peginterferon ribavirin in chronic hepatitis C using classification and regression tree analysis. Hepatol Res. 2010.04; 40 (4): 251-260. ( PubMed , DOI )

  8. Junko Akiyama, Ryuichi Okamoto, Michiko Iwasaki, Xiu Zheng, Shiro Yui, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe: Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells. Biochem. Biophys. Res. Commun. 2010.03; 393 (4): 662-667. ( PubMed , DOI )

  9. Jun Itakura, Masayuki Kurosaki, Yoshie Itakura, Sinya Maekawa, Yasuhiro Asahina, Namiki Izumi, Nobuyuki Enomoto: Reproducibility and usability of chronic virus infection model using agent-based simulation; comparing with a mathematical model. Biosystems. 2010.01; 99 (1): 70-78. ( PubMed , DOI )

  10. Namiki Izumi, Yasuhiro Asahina, Masayuki Kurosaki: Predictors of virological response to a combination therapy with pegylated interferon plus ribavirin including virus and host factors. Hepat Res Treat. 2010; 2010 703602. ( PubMed , DOI )

  1. Yasuhiro Itsui, Naoya Sakamoto, Sei Kakinuma, Mina Nakagawa, Yuko Sekine-Osajima, Megumi Tasaka-Fujita, Yuki Nishimura-Sakurai, Gouki Suda, Yuko Karakama, Kako Mishima, Machi Yamamoto, Takako Watanabe, Mayumi Ueyama, Yusuke Funaoka, Seishin Azuma, Mamoru Watanabe: Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein. Hepatology. 2009.12; 50 (6): 1727-1737. ( PubMed , DOI )

  2. Yasuhiro Nemoto, Takanori Kanai, Kaori Kameyama, Tamako Shinohara, Naoya Sakamoto, Teruji Totsuka, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Tetsuo Sudo, Satoshi Matsumoto, Mamoru Watanabe: Long-lived colitogenic CD4+ memory T cells residing outside the intestine participate in the perpetuation of chronic colitis. J. Immunol.. 2009.10; 183 (8): 5059-5068. ( PubMed , DOI )

  3. Nemoto Y, Kanai T, Kameyama K, Shinohara T, Sakamoto N, Totsuka T, Okamoto R, Tsuchiya K, Nakamura T, Sudo T, Matsumoto S, Watanabe M.: Long-lived colitogenic CD4+ memory T cells residing outside the intestine participate in the perpetuation of chronic colitis. J Immunol. 2009.10;

  4. Tomita T, Kanai T, Totsuka T, Nemoto Y, Okamoto R, Tsuchiya K, Sakamoto N, Ohteki T, Hibi T, Watanabe M.: IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis. Eur J Immunol. 2009.10;

  5. Takayuki Tomita, Takanori Kanai, Teruji Totsuka, Yasuhiro Nemoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Naoya Sakamoto, Toshiaki Ohteki, Toshifumi Hibi, Mamoru Watanabe: IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis. Eur J Immunol. 2009.10; 39 (10): 2737-2747. ( PubMed , DOI )

  6. Kanai T, Nemoto Y, Kamada N, Totsuka T, Hisamatsu T, Watanabe M, Hibi T.: Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease. Curr Opin Gastroenterol. 2009.07;

  7. Kanai T, Nemoto Y, Tomita T, Totsuka T, Watanabe M, Hibi T.: Persistent retention of colitogenic CD4+ memory T cells causes inflammatory bowel diseases to become intractable. Inflamm Bowel Dis. 2009.06;

  8. Teruji Totsuka, Takanori Kanai, Yasuhiro Nemoto, Takayuki Tomita, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Naoya Sakamoto, Hisaya Akiba, Ko Okumura, Hideo Yagita, Mamoru Watanabe: RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis. J. Immunol.. 2009.05; 182 (10): 6079-6087. ( PubMed , DOI )

  9. Totsuka T, Kanai T, Nemoto Y, Tomita T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Akiba H, Okumura K, Yagita H, Watanabe M.: RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis. J Immunol. 2009.05;

  10. Onizawa M, Nagaishi T, Kanai T, Nagano K, Oshima S, Nemoto Y, Yoshioka A, Totsuka T, Okamoto R, Nakamura T, Sakamoto N, Tsuchiya K, Aoki K, Ohya K, Yagita H, Watanabe M: Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis. Am J Physiol Gastrointest Liver Physiol. 2009.04; 296 (4): G850-9. ( PubMed , DOI )

  11. Yasuhiro Asahina, Hiroyuki Nakanishi, Namiki Izumi: Laparoscopic radiofrequency ablation for hepatocellular carcinoma. Dig Endosc. 2009.04; 21 (2): 67-72. ( PubMed , DOI )

  12. Onizawa M, Nagaishi T, Kanai T, Nagano K, Oshima S, Nemoto Y, Yoshioka A, Totsuka T, Okamoto R, Nakamura T, Sakamoto N, Tsuchiya K, Aoki K, Ohya K, Yagita H, Watanabe M.: Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis. Am J Physiol Gastrointest Liver Physiol. 2009.04;

  13. Minekazu Murayama, Ryuichi Okamoto, Kiichiro Tsuchiya, Junko Akiyama, Tetsuya Nakamura, Naoya Sakamoto, Takanori Kanai, Mamoru Watanabe: Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells. J. Gastroenterol.. 2009.03; 44 (3): 173-182. ( PubMed , DOI )

  14. Ryuichi Okamoto, Kiichiro Tsuchiya, Yasuhiro Nemoto, Junko Akiyama, Tetsuya Nakamura, Takanori Kanai, Mamoru Watanabe: Requirement of Notch activation during regeneration of the intestinal epithelia. Am J Physiol Gastrointest Liver Physiol. 2009.01; 296 (1): G23-G35. ( PubMed , DOI )

  15. Okamoto R, Tsuchiya K, Nemoto Y, Akiyama J, Nakamura T, Kanai T, Watanabe M.: Requirement of Notch activation during regeneration of the intestinal epithelia. Am J Physiol Gastrointest Liver Physiol. 2009.01;

  1. Toshimitsu Fujii, Takayuki Tomita, Takanori Kanai, Yasuhiro Nemoto, Teruji Totsuka, Naoya Sakamoto, Tetsuya Nakamura, Kiichiro Tsuchiya, Ryuichi Okamoto, Mamoru Watanabe: FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow. Eur J Immunol. 2008.12; 38 (12): 3290-3303. ( PubMed , DOI )

  2. Takayuki Tomita, Takanori Kanai, Yasuhiro Nemoto, Toshimitsu Fujii, Kengo Nozaki, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Naoya Sakamoto, Teruji Totsuka, Mamoru Watanabe: Colitogenic CD4+ effector-memory T cells actively recirculate in chronic colitic mice. Inflamm. Bowel Dis.. 2008.12; 14 (12): 1630-1640. ( PubMed , DOI )

  3. Fujii T, Tomita T, Kanai T, Nemoto Y, Totsuka T, Sakamoto N, Nakamura T, Tsuchiya K, Okamoto R, Watanabe M.: FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow. Eur J Immunol. 2008.12;

  4. Tomita T, Kanai T, Nemoto Y, Fujii T, Nozaki K, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Totsuka T, Watanabe M.: Colitogenic CD4+ effector-memory T cells actively recirculate in chronic colitic mice. Inflamm Bowel Dis. 2008.12;

  5. A Araki, K Tsuchiya, E Okada, S Suzuki, S Oshima, R Okamoto, T Kanai, M Watanabe: Single-operator method for double-balloon endoscopy: a pilot study. Endoscopy. 2008.11; 40 (11): 936-938. ( PubMed , DOI )

  6. Nemoto Y, Kanai T, Tohda S, Totsuka T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Fukuda T, Miura O, Yagita H, Watanabe M: Negative feedback regulation of colitogenic CD4+ T cells by increased granulopoiesis. Inflamm Bowel Dis. 2008.11; 14 (11): 1491-1503. ( PubMed , DOI )

  7. Nemoto Y, Kanai T, Tohda S, Totsuka T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Fukuda T, Miura O, Yagita H, Watanabe M.: Negative feedback regulation of colitogenic CD4+ T cells by increased granulopoiesis. Inflamm Bowel Dis. 2008.11;

  8. Atsushi Yoshioka, Ryuichi Okamoto, Shigeru Oshima, Junko Akiyama, Kiichiro Tsuchiya, Tetsuya Nakamura, Takanori Kanai, Mamoru Watanabe: Flagellin stimulation suppresses IL-7 secretion of intestinal epithelial cells. Cytokine. 2008.10; 44 (1): 57-64. ( PubMed , DOI )

  9. Kimihiro Hino, Kiichiro Tsuchiya, Taro Fukao, Kotaro Kiga, Ryuichi Okamoto, Takanori Kanai, Mamoru Watanabe: Inducible expression of microRNA-194 is regulated by HNF-1alpha during intestinal epithelial cell differentiation. RNA. 2008.07; 14 (7): 1433-1442. ( PubMed , DOI )

  10. Teruji Totsuka, Takanori Kanai, Yasuhiro Nemoto, Takayuki Tomita, Kiichiro Tsuchiya, Naoya Sakamoto, Ryuichi Okamoto, Mamoru Watanabe: Immunosenescent colitogenic CD4(+) T cells convert to regulatory cells and suppress colitis. Eur J Immunol. 2008.05; 38 (5): 1275-1286. ( PubMed , DOI )

  11. Takayuki Tomita, Takanori Kanai, Toshimitsu Fujii, Yasuhiro Nemoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Teruji Totsuka, Naoya Sakamoto, Mamoru Watanabe: Continuous generation of colitogenic CD4(+) T cells in persistent colitis. Eur J Immunol. 2008.05; 38 (5): 1264-1274. ( PubMed , DOI )

  12. Masayuki Kurosaki, Kotaro Matsunaga, Itsuko Hirayama, Tomohiro Tanaka, Mitsuaki Sato, Nobutoshi Komatsu, Naoki Umeda, Takanori Hosokawa, Ken Ueda, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Yasuhiro Asahina, Shozo Miyake, Nobuyuki Enomoto, Namiki Izumi: The presence of steatosis and elevation of alanine aminotransferase levels are associated with fibrosis progression in chronic hepatitis C with non-response to interferon therapy. J Hepatol. 2008.05; 48 (5): 736-742. ( PubMed , DOI )

  13. Yasuhiro Asahina, Namiki Izumi, Itsuko Hirayama, Tomohiro Tanaka, Mitsuaki Sato, Yutaka Yasui, Nobutoshi Komatsu, Naoki Umeda, Takanori Hosokawa, Ken Ueda, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Masayuki Kurosaki, Nobuyuki Enomoto, Megumi Tasaka, Naoya Sakamoto, Shozo Miyake: Potential relevance of cytoplasmic viral sensors and related regulators involving innate immunity in antiviral response. Gastroenterology. 2008.05; 134 (5): 1396-1405. ( PubMed , DOI )

  14. Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N, Watanabe M.: Continuous generation of colitogenic CD4(+) T cells in persistent colitis. Eur J Immunol. 2008.05;

  15. Totsuka T, Kanai T, Nemoto Y, Tomita T, Tsuchiya K, Sakamoto N, Okamoto R, Watanabe M.: Immunosenescent colitogenic CD4(+) T cells convert to regulatory cells and suppress colitis. Eur J Immunol. 2008.05;

  16. Takayuki Tomita, Takanori Kanai, Toshimitsu Fujii, Yasuhiro Nemoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Teruji Totsuka, Naoya Sakamoto, Shizuo Akira, Mamoru Watanabe: MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis. J. Immunol.. 2008.04; 180 (8): 5291-5299. ( PubMed )

  17. Mikayo Aragaki, Kiichiro Tsuchiya, Ryuichi Okamoto, Sanae Yoshioka, Tetsuya Nakamura, Naoya Sakamoto, Takanori Kanai, Mamoru Watanabe: Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer. Biochem. Biophys. Res. Commun. 2008.04; 368 (4): 923-929. ( PubMed , DOI )

  18. Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N, Akira S, Watanabe M.: MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis. J Immunol. 2008.04;

  19. Takayuki Tomita, Takanori Kanai, Yasuhiro Nemoto, Teruji Totsuka, Ryuichi Okamoto, Kiichiro Tsuchiya, Naoya Sakamoto, Mamoru Watanabe: Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis. J. Immunol.. 2008.01; 180 (1): 383-390. ( PubMed )

  20. Y Ito, T Kanai, T Totsuka, R Okamoto, K Tsuchiya, Y Nemoto, A Yoshioka, T Tomita, T Nagaishi, N Sakamoto, T Sakanishi, K Okumura, H Yagita, M Watanabe: Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis. Am J Physiol Gastrointest Liver Physiol. 2008.01; 294 (1): G199-G207. ( PubMed , DOI )

  21. Ito Y, Kanai T, Totsuka T, Okamoto R, Tsuchiya K, Nemoto Y, Yoshioka A, Tomita T, Nagaishi T, Sakamoto N, Sakanishi T, Okumura K, Yagita H, Watanabe M.: Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis. Am J Physiol Gastrointest Liver Physiol. 2008.01;

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  1. Noboru Shinkai, Yasuhito Tanaka, Kiyoaki Ito, Motokazu Mukaide, Izumi Hasegawa, Yasuhiro Asahina, Namiki Izumi, Hiroshi Yatsuhashi, Etsuro Orito, Takashi Joh, Masashi Mizokami: Influence of hepatitis B virus X and core promoter mutations on hepatocellular carcinoma among patients infected with subgenotype C2. J Clin Microbiol. 2007.10; 45 (10): 3191-3197. ( PubMed , DOI )

  2. Namiki Izumi, Yasuhiro Asahina, Kaoru Tsuchiya, Masayuki Kurosaki, Hiroyuki Nakanishi, Takatoshi Kitamura, Masakatsu Uchihara, Schozo Miyake: Repeated radiofrequency ablation for the distant recurrence in the liver in patients with chronic hepatitis C virus infection achieving long-term survival. Hepatol Res. 2007.09; 37 Suppl 2 S254-S263. ( PubMed , DOI )

  3. Teruji Totsuka, Takanori Kanai, Yasuhiro Nemoto, Shin Makita, Ryuichi Okamoto, Kiichiro Tsuchiya, Mamoru Watanabe: IL-7 Is essential for the development and the persistence of chronic colitis. J. Immunol.. 2007.04; 178 (8): 4737-4748. ( PubMed )

  4. Shin Makita, Takanori Kanai, Yasuhiro Nemoto, Teruji Totsuka, Ryuichi Okamoto, Kiichiro Tsuchiya, Masafumi Yamamoto, Hiroshi Kiyono, Mamoru Watanabe: Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation. J. Immunol.. 2007.04; 178 (8): 4937-4946. ( PubMed )

  5. Makita S, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Yamamoto M, Kiyono H, Watanabe M.: Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation. J Immunol. 2007.04;

  6. Totsuka T, Kanai T, Nemoto Y, Makita S, Okamoto R, Tsuchiya K, Watanabe M.: IL-7 Is essential for the development and the persistence of chronic colitis. J Immunol. 2007.04;

  7. Takanori Kanai, Shin Makita, Takahiro Kawamura, Yasuhiro Nemoto, Daisuke Kubota, Kazuyoshi Nagayama, Teruji Totsuka, Mamoru Watanabe: Extracorporeal elimination of TNF-alpha-producing CD14(dull)CD16(+) monocytes in leukocytapheresis therapy for ulcerative colitis. Inflamm Bowel Dis. 2007.03; 13 (3): 284-290. ( PubMed , DOI )

  8. Kanai T, Makita S, Kawamura T, Nemoto Y, Kubota D, Nagayama K, Totsuka T, Watanabe M.: Extracorporeal elimination of TNF-alpha-producing CD14(dull)CD16(+) monocytes in leukocytapheresis therapy for ulcerative colitis. Inflamm Bowel Dis. 2007.03;

  9. Nagawa F, Kishishita N, Shimizu K, Hirose S, Miyoshi M, Nezu J, Nishimura T, Nishizumi H, Takahashi Y, Hashimoto S, Takeuchi M, Miyajima A, Takemori T, Otsuka AJ, Sakano H: Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice. Nature immunology. 2007.02; 8 (2): 206-13. ( PubMed , DOI )

  10. Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Takanori Kanai, Mamoru Watanabe: Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer. Gastroenterology. 2007.01; 132 (1): 208-220. ( PubMed , DOI )

  11. Yasuhiro Nemoto, Takanori Kanai, Shin Makita, Ryuichi Okamoto, Teruji Totsuka, Kiyoshi Takeda, Mamoru Watanabe: Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis. Gastroenterology. 2007.01; 132 (1): 176-189. ( PubMed , DOI )

  12. Nemoto Y, Kanai T, Makita S, Okamoto R, Totsuka T, Takeda K, Watanabe M.: Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis. Gastroenterology. 2007.01;

  1. Yasuhito Tanaka, Motokazu Mukaide, Etsuro Orito, Man-Fung Yuen, Kiyoaki Ito, Fuat Kurbanov, Fuminaka Sugauchi, Yasuhiro Asahina, Namiki Izumi, Michio Kato, Ching-Lung Lai, Ryuzo Ueda, Masashi Mizokami: Specific mutations in enhancer II/core promoter of hepatitis B virus subgenotypes C1/C2 increase the risk of hepatocellular carcinoma. J Hepatol. 2006.11; 45 (5): 646-653. ( PubMed , DOI )

  2. R Fujii, T Kanai, Y Nemoto, S Makita, S Oshima, R Okamoto, K Tsuchiya, T Totsuka, M Watanabe: FTY720 suppresses CD4+CD44highCD62L- effector memory T cell-mediated colitis. Am J Physiol Gastrointest Liver Physiol. 2006.08; 291 (2): G267-G274. ( PubMed , DOI )

  3. Atsushi Ozasa, Yasuhito Tanaka, Etsuro Orito, Masaya Sugiyama, Jong-Hon Kang, Shuhei Hige, Tomoyuki Kuramitsu, Kazuyuki Suzuki, Eiji Tanaka, Shunichi Okada, Hajime Tokita, Yasuhiro Asahina, Kazuaki Inoue, Shinichi Kakumu, Takeshi Okanoue, Yoshikazu Murawaki, Keisuke Hino, Morikazu Onji, Hiroshi Yatsuhashi, Hiroshi Sakugawa, Yuzo Miyakawa, Ryuzo Ueda, Masashi Mizokami: Influence of genotypes and precore mutations on fulminant or chronic outcome of acute hepatitis B virus infection. Hepatology. 2006.08; 44 (2): 326-334. ( PubMed , DOI )

  4. Fujii R, Kanai T, Nemoto Y, Makita S, Oshima S, Okamoto R, Tsuchiya K, Totsuka T, Watanabe M.: FTY720 suppresses CD4+CD44highCD62L- effector memory T cell-mediated colitis. Am J Physiol Gastrointest Liver Physiol. 2006.08;

  5. Takanori Kanai, Koji Uraushihara, Teruji Totsuka, Yasuhiro Nemoto, Rei Fujii, Takahiro Kawamura, Shin Makita, Daisuke Sawada, Hideo Yagita, Ko Okumura, Mamoru Watanabe: Ameliorating effect of saporin-conjugated anti-CD11b monoclonal antibody in a murine T-cell-mediated chronic colitis. J Gastroenterol Hepatol. 2006.07; 21 (7): 1136-1142. ( PubMed , DOI )

  6. Kanai T, Uraushihara K, Totsuka T, Nemoto Y, Fujii R, Kawamura T, Makita S, Sawada D, Yagita H, Okumura K, Watanabe M.: Ameliorating effect of saporin-conjugated anti-CD11b monoclonal antibody in a murine T-cell-mediated chronic colitis. J Gastroenterol Hepatol. 2006.06;

  7. Ryuichi Okamoto, Tomoko Matsumoto, Mamoru Watanabe: Regeneration of the intestinal epithelia: regulation of bone marrow-derived epithelial cell differentiation towards secretory lineage cells. Hum. Cell. 2006.05; 19 (2): 71-75. ( PubMed , DOI )

  8. Kanai T, Tanimoto K, Nemoto Y, Fujii R, Makita S, Totsuka T, Watanabe M.: Naturally arising CD4+CD25+ regulatory T cells suppress the expansion of colitogenic CD4+CD44highCD62L- effector memory T cells. Am J Physiol Gastrointest Liver Physiol. 2006.05;

  9. Yasuhito Tanaka, Kazuaki Takahashi, Etsuro Orito, Yoshiyasu Karino, Jong-Hon Kang, Kazuyuki Suzuki, Atsushi Matsui, Akiko Hori, Hiroyuki Matsuda, Hiroshi Sakugawa, Yasuhiro Asahina, Tsuneo Kitamura, Masashi Mizokami, Shunji Mishiro: Molecular tracing of Japan-indigenous hepatitis E viruses. J Gen Virol. 2006.04; 87 (Pt 4): 949-954. ( PubMed , DOI )

  10. Takanori Kanai, Takahiro Kawamura, Taeko Dohi, Shin Makita, Yasuhiro Nemoto, Teruji Totsuka, Mamoru Watanabe: TH1/TH2-mediated colitis induced by adoptive transfer of CD4+CD45RBhigh T lymphocytes into nude mice. Inflamm Bowel Dis. 2006.02; 12 (2): 89-99. ( PubMed , DOI )

  11. Kanai T, Kawamura T, Dohi T, Makita S, Nemoto Y, Totsuka T, Watanabe M.: TH1/TH2-mediated colitis induced by adoptive transfer of CD4+CD45RBhigh T lymphocytes into nude mice. Inflamm Bowel Dis. 2006.02;

  1. Masayuki Kurosaki, Namiki Izumi, Yuko Onuki, Yuki Nishimura, Ken Ueda, Kaoru Tsuchiya, Hiroyuki Nakanishi, Takatoshi Kitamura, Yasuhiro Asahina, Masakatsu Uchihara, Shozo Miyake: Serum KL-6 as a novel tumor marker for hepatocellular carcinoma in hepatitis C virus infected patients. Hepatol Res. 2005.11; 33 (3): 250-257. ( PubMed , DOI )

  2. Ryuichi Okamoto, Mamoru Watanabe: Cellular and molecular mechanisms of the epithelial repair in IBD. Dig. Dis. Sci.. 2005.10; 50 Suppl 1 S34-S38. ( PubMed , DOI )

  3. Yasuhiro Asahina, Namiki Izumi, Nobuyuki Enomoto, Masakatsu Uchihara, Masayuki Kurosaki, Yuko Onuki, Yuki Nishimura, Ken Ueda, Kaoru Tsuchiya, Hiroyuki Nakanishi, Takatoshi Kitamura, Shozo Miyake: Mutagenic effects of ribavirin and response to interferon/ribavirin combination therapy in chronic hepatitis C. J Hepatol. 2005.10; 43 (4): 623-629. ( PubMed , DOI )

  4. Hamano K, Sakamoto N, Enomoto N, Izumi N, Asahina Y, Kurosaki M, Ueda E, Tanabe Y, Maekawa S, Itakura J, Watanabe H, Kakinuma S, Watanabe M: Mutations in the NS5B region of the hepatitis C virus genome correlate with clinical outcomes of interferon-alpha plus ribavirin combination therapy. J Gastroenterol Hepatol. 2005.09; 20 (9): 1401-1409. ( PubMed , DOI )

  5. Teruji Totsuka, Takanori Kanai, Shin Makita, Rei Fujii, Yasuhiro Nemoto, Shigeru Oshima, Ryuichi Okamoto, Akemi Koyanagi, Hisaya Akiba, Ko Okumura, Hideo Yagita, Mamoru Watanabe: Regulation of murine chronic colitis by CD4+CD25- programmed death-1+ T cells. Eur J Immunol. 2005.06; 35 (6): 1773-1785. ( PubMed , DOI )

  6. Matsumoto T, Okamoto R, Yajima T, Mori T, Okamoto S, Ikeda Y, Mukai M, Yamazaki M, Oshima S, Tsuchiya K, Nakamura T, Kanai T, Okano H, Inazawa J, Hibi T, Watanabe M: Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine. Gastroenterology. 2005.06; 128 (7): 1851-1867. ( PubMed , DOI )

  7. Totsuka T, Kanai T, Makita S, Fujii R, Nemoto Y, Oshima S, Okamoto R, Koyanagi A, Akiba H, Okumura K, Yagita H, Watanabe M.: Regulation of murine chronic colitis by CD4+CD25- programmed death-1+ T cells. Eur J Immunol. 2005.06;

  8. Shin Namiki, Tetsuya Nakamura, Shigeru Oshima, Motomi Yamazaki, Yuko Sekine, Kiichiro Tsuchiya, Ryuichi Okamoto, Takanori Kanai, Mamoru Watanabe: IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome. FEBS Lett.. 2005.05; 579 (13): 2781-2787. ( PubMed , DOI )

  9. Eriko Okada, Motomi Yamazaki, Masanobu Tanabe, Tsutomu Takeuchi, Masanobu Nanno, Shigeru Oshima, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Takanori Kanai, Toshifumi Hibi, Mamoru Watanabe: IL-7 exacerbates chronic colitis with expansion of memory IL-7Rhigh CD4+ mucosal T cells in mice. Am J Physiol Gastrointest Liver Physiol. 2005.04; 288 (4): G745-G754. ( PubMed , DOI )

  10. Hiroyuki Nakanishi, Masayuki Kurosaki, Yasuhiro Asahina, Yuko Onuki, Ken Ueda, Yuki Nishimura, Kaoru Tsuchiya, Takatoshi Kitamura, Masakatsu Uchihara, Shozo Miyake, Nobuyuki Enomoto, Namiki Izumi: Polymerase domain B mutation is associated with hepatitis relapse during long-term lamivudine therapy for chronic hepatitis B. Intervirology. 2005; 48 (6): 381-388. ( PubMed , DOI )

  11. Namiki Izumi, Asahina Yasuhiro, Masayuki Kurosaki, Yuko Onuki, Yuki Nishimura, Kazunari Inoue, Ken Ueda, Kaoru Tsuchiya, Hiroyuki Nakanishi, Masakatsu Uchihara, Shozo Miyake: Development of hepatocellular carcinoma after interferon therapy in chronic hepatitis C. Is it possible to reduce the incidence by ribanirin and IFN combination therapy? Intervirology. 2005; 48 (1): 59-63. ( PubMed , DOI )

  1. Kanazawa N, Kurosaki M, Sakamoto N, Enomoto N, Itsui Y, Yamashiro T, Tanabe Y, Maekawa S, Nakagawa M, Chen CH, Kakinuma S, Oshima S, Nakamura T, Kato T, Wakita T, Watanabe M: Regulation of hepatitis C virus replication by interferon regulatory factor 1. J Virol. 2004.09; 78 (18): 9713-9720. ( PubMed , DOI )

  2. Jun Itakura, Namiki Izumi, Yuki Nishimura, Kazunari Inoue, Ken Ueda, Hiroyuki Nakanishi, Kaoru Tsuchiya, Kosei Hamano, Yasuhiro Asahina, Masayuki Kurosaki, Masakatsu Uchihara, Shozo Miyake: Prospective randomized crossover trial of combination therapy with bezafibrate and UDCA for primary biliary cirrhosis. Hepatol Res. 2004.08; 29 (4): 216-222. ( PubMed , DOI )

  3. Oshima S, Nakamura T, Namiki S, Okada E, Tsuchiya K, Okamoto R, Yamazaki M, Yokota T, Aida M, Yamaguchi Y, Kanai T, Handa H, Watanabe M: Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. Mol Cell Biol. 2004.07; 24 (14): 6298-6310. ( PubMed , DOI )

  4. Kenichi Ishii, Takanori Kanai, Teruji Totsuka, Koji Uraushihara, Takahiro Ishikura, Motomi Yamazaki, Ryuichi Okamoto, Akihiro Araki, Tatsuya Miyata, Katsuaki Tezuka, Tetsuya Nakamura, Mamoru Watanabe: Hyperexpression of inducible costimulator on lamina propria mononuclear cells in rat dextran sulfate sodium colitis. J. Gastroenterol. Hepatol.. 2004.02; 19 (2): 174-181. ( PubMed )

  5. Ryuichi Okamoto, Mamoru Watanabe: Molecular and clinical basis for the regeneration of human gastrointestinal epithelia. J. Gastroenterol.. 2004.01; 39 (1): 1-6. ( PubMed , DOI )

  6. Namiki Izumi, Yasuhiro Asahina, Masayuki Kurosaki, Masakatsu Uchihara, Yuki Nishimura, Kazunari Inoue, Ken Ueda, Kaoru Tsuchiya, Kousei Hamano, Jun Itakura, Shozo Miyake: A comparison of the exponential decay slope between PEG-IFN alfa-2b/ribavirin and IFN alfa-2b/ribavirin combination therapy in patients with chronic hepatitis C genotype 1b infection and a high viral load. Intervirology. 2004; 47 (2): 102-107. ( PubMed , DOI )

  1. Yasuhiro Asahina, Namiki Izumi, Masakatsu Uchihara, Osamu Noguchi, Yuki Nishimura, Kazunari Inoue, Ken Ueda, Kaoru Tsuchiya, Kosei Hamano, Jun Itakura, Shozo Miyake: Core promoter/pre-core mutations are associated with lamivudine-induced HBeAg loss in chronic hepatitis B with genotype C. J Hepatol. 2003.12; 39 (6): 1063-1069. ( PubMed , DOI )

  2. Yasuhiro Asahina, Namiki Izumi, Masakatsu Uchihara, Osamu Noguchi, Ken Ueda, Kazunari Inoue, Yuki Nishimura, Kaoru Tsuchiya, Kosei Hamano, Jun Itakura, Yoshiro Himeno, Morio Koike, Shozo Miyake: Assessment of Kupffer cells by ferumoxides-enhanced MR imaging is beneficial for diagnosis of hepatocellular carcinoma: comparison of pathological diagnosis and perfusion patterns assessed by CT hepatic arteriography and CT arterioportography. Hepatol Res. 2003.11; 27 (3): 196-204. ( PubMed , DOI )

  3. Ryuichi Okamoto, Mamoru Watanabe: Prospects for regeneration of gastrointestinal epithelia with donor derived cells. Trends Mol Med. 2003.09; 9 (7): 286-290.

  4. Yasuhiro Asahina, Namiki Izumi, Masakatsu Uchihara, Osamu Noguchi, Yuki Nishimura, Kazunari Inoue, Ken Ueda, Kaoru Tsuchiya, Kosei Hamano, Jun Itakura, Shozo Miyake: Interferon-stimulated gene expression and hepatitis C viral dynamics during different interferon regimens. J Hepatol. 2003.09; 39 (3): 421-427. ( PubMed , DOI )

  5. Motomi Yamazaki, Tomoharu Yajima, Masanobu Tanabe, Kazuto Fukui, Eriko Okada, Ryuichi Okamoto, Shigeru Oshima, Tetsuya Nakamura, Takanori Kanai, Masahiro Uehira, Tsutomu Takeuchi, Hiromichi Ishikawa, Toshifumi Hibi, Mamoru Watanabe: Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis. J. Immunol.. 2003.08; 171 (3): 1556-1563. ( PubMed )

  6. Ryuichi Okamoto, Mamoru Watanabe: Prospects for regeneration of gastrointestinal epithelia using bone-marrow cells. Trends Mol Med. 2003.07; 9 (7): 286-290. ( PubMed , DOI )

  7. Mamoru Watanabe, Motomi Yamazaki, Ryuichi Okamoto, Shinya Ohoka, Akihiro Araki, Tetsuya Nakamura, Takanori Kanai: Therapeutic approaches to chronic intestinal inflammation by specific targeting of mucosal IL-7/IL-7R signal pathway. Curr Drug Targets Inflamm Allergy. 2003.06; 2 (2): 119-123. ( PubMed )

  8. Teruji Totsuka, Takanori Kanai, Ryoichi Iiyama, Koji Uraushihara, Motomi Yamazaki, Ryuichi Okamoto, Toshifumi Hibi, Katsunari Tezuka, Miyuki Azuma, Hisaya Akiba, Hideo Yagita, Ko Okumura, Mamoru Watanabe: Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis. Gastroenterology. 2003.02; 124 (2): 410-421. ( PubMed , DOI )

  1. Nobuhiko Kanazawa, Namiki Izumi, Kaoru Tsuchiya, Kaoru Sakurai, Kosei Hamano, Jun Itakura, Yasuhiro Asahina, Osamu Noguchi, Masakatsu Uchihara, Shozo Miyake, Naoto Miyakawa, Yasuhiro Kawachi, Hidetoshi Shiotsu, Kazuhiro Taki, Yoshiro Himeno, Nobuyuki Enomoto, Mamoru Watanabe, Takahiro Sakai: A case of primary leiomyoma of the liver in a patient without evidence of immunosuppression. Hepatol Res. 2002.09; 24 (1): 80. ( PubMed , DOI )

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  1. Takanori Kanai, Mamoru Watanabe, Akira Okazawa, Toshiro Sato, Motomi Yamazaki, Susumu Okamoto, Hiromasa Ishii, Teruji Totsuka, Ryoichi Iiyama, Ryuichi Okamoto, Masao Ikeda, Masashi Kurimoto, Kiyoshi Takeda, Shizuo Akira, Toshifumi Hibi: Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease. Gastroenterology. 2001.10; 121 (4): 875-888. ( PubMed )

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