Department of Medical Biochemistry

81  articles.  
* There may be some overlapped articles listed due to the difference of format.

  1. 大石由美子: 脂質代謝による老化関連自然免疫シグナルの制御 The Lipid. 2025.10; 36 (2):

  2. Lin Liu, Tomoki Chiba, Takahide Matsushima, Maiko Inotsume, Tomomi Kato, Yuichi Hiraoka, Hiroshi Asahara: Gene dosage-dependent roles of Mkx in postnatal tendon development and maintenance revealed by conditional deletion. Dev Biol. 2025.10; 526 15-25. ( PubMed , DOI )

  3. Azusa Honda, Hiroyuki Koike, Teruyuki Dohi, Eri Toyohara, Sumio Hayakawa, Kazuyuki Tobe, Ichiro Manabe, Rei Ogawa, Yumiko Oishi: CD206+ macrophages facilitate wound healing through interactions with Gpnmbhi fibroblasts EMBO Rep. 2025.07; 26 (14): 3679-3704. ( PubMed , DOI )

  4. Hiroyuki Koike, Miho Sugimura, Rie Ouchi, Yuki Yoshimoto, Ichiro Manabe, Yumiko Oishi: Macrophage Subpopulation Promotes Skeletal Muscle Regeneration Through HGF/MET Signaling-Mediated Skeletal Muscle Stem Cell Proliferation. Aging Cell. 2025.06; 24 (6): e70042. ( PubMed , DOI )

  1. Otomo K, Omura T, Nozawa Y, Edwards SJ, Sato Y, Saito Y, Yagishita S, Uchida H, Watakabe Y, Naitou K, Yanai R, Sahara N, Takagi S, Katayama R, Iwata Y, Shiokawa T, Hayakawa Y, Otsuka K, Watanabe-Takano H, Haneda Y, Fukuhara S, Fujiwara M, Nii T, Meno C, Takeshita N, Yashiro K, Rosales Rocabado JM, Kaku M, Yamada T, Oishi Y, Koike H, Cheng Y, Sekine K, Koga JI, Sugiyama K, Kimura K, Karube F, Kim H, Manabe I, Nemoto T, Tainaka K, Hamada A, Brismar H, Susaki EA: descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques. Nature communications. 2024.06; 15 (1): 4941. ( PubMed , DOI )

  2. Mao Kuriki, Amaury Korb, Glenda Comai, Shahragim Tajbakhsh: Interplay between Pitx2 and Pax7 temporally governs specification of extraocular muscle stem cells. PLoS Genet. 2024.06; 20 (6): e1010935. ( PubMed , DOI )

  3. Narai-Kanayama A, Hayakawa S, Yoshino T, Honda F, Matsuda H, Oishi Y: Differential effects of theasinensins and epigallocatechin-3-O-gallate on phospholipid bilayer structure and liposomal aggregation. Biochimica et biophysica acta. Biomembranes. 2024.04; 1866 (5): 184312. ( PubMed , DOI )

  4. Oishi, Y; Koike, H; Kumagami, N; Nakagawa, Y; Araki, M; Taketomi, Y; Miki, Y; Matsuda, S; Kim, H; Matsuzaka, T; Ozawa, H; Shimano, H; Murakami, M; Manabe, I: Macrophage SREBP1 regulates skeletal muscle regeneration (vol 14, 1251784, 2024) FRONTIERS IN IMMUNOLOGY. 2024.04; 15 1382077. ( PubMed , DOI )

  5. Daniela Di Girolamo, Maria Benavente-Diaz, Melania Murolo, Alexandre Grimaldi, Priscilla Thomas Lopes, Brendan Evano, Mao Kuriki, Stamatia Gioftsidi, Vincent Laville, Jean-Yves Tinevez, Gaëlle Letort, Sebastian Mella, Shahragim Tajbakhsh, Glenda Comai: Extraocular muscle stem cells exhibit distinct cellular properties associated with non-muscle molecular signatures. Development. 2024.02; 151 (4): ( PubMed , DOI )

  6. Sukhorukov VN, Khotina VA, Borodko DD, Ekta MB, Oishi Y, Omelchenko AV, Kolmychkova KI, Nikiforov NG, Sobenin IA, Orekhov AN: Evidence for the Involvement of Gene Regulation of Inflammatory Molecules in the Accumulation of Intracellular Cholesterol: The Mechanism of Foam Cell Formation in Atherosclerosis. Current medicinal chemistry. 2024.02; 32 (9): 1755-1769. ( PubMed , DOI )

  1. Yuki Yoshimoto, Yumiko Oishi: Mechanisms of skeletal muscle-tendon development and regeneration/healing as potential therapeutic targets. Pharmacol Ther. 2023.03; 243 108357. ( PubMed , DOI )

  2. Maiko Inotsume, Tomoki Chiba, Takahide Matsushima, Ryota Kurimoto, Mitsuyo Nakajima, Tomomi Kato, Kana Shishido, Lin Liu, Koichi Kawakami, Hiroshi Asahara: One-step generation of mice with gene editing by Tol2 transposon-dependent gRNA delivery. FEBS Lett. 2023.03; ( PubMed , DOI )

  3. Caspase-11 contributes to site-1 protease cleavage and SREBP1 activation in the inflammatory response of macrophages 2023.01; 14 1009973. ( PubMed , DOI )

  1. Cyclic stretch regulates immune responses via tank‐binding kinase 1 expression in macrophages 2022.12; 13 (1): 185-194. ( PubMed , DOI )

  2. Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration 2022.11; 13 (1): 7058. ( PubMed , DOI )

  3. Koike Hiroyuki, Manabe Ichiro, Oishi Yumiko: 骨格筋再生における協調的細胞間相互作用のメカニズム(Mechanisms of cooperative cell-cell interactions in skeletal muscle regeneration) Inflammation and Regeneration. 2022.11; 42 1 of 11-11 of 11. ( ichushi )

  4. Mechanisms of cooperative cell-cell interactions in skeletal muscle regeneration 2022.11; 42 (1): 48. ( PubMed , DOI )

  5. Sumio Hayakawa, Atsushi Tamura, Nikita Nikiforov, Hiroyuki Koike, Fujimi Kudo, Yinglan Cheng, Takuro Miyazaki, Marina Kubekina, Tatiana V. Kirichenko, Alexander N. Orekhov, Nobuhiko Yui, Ichiro Manabe, Yumiko Oishi: Activated metabolism of cholesterol and its binding to Myd88 via its CRAC domain are integral to the macrophage innate response. JCI Insight. 2022.10;

  6. Antitumor effect of memantine is related to the formation of the splicing isoform of GLG1, a decoy FGF‑binding protein. 2022.07; 61 (1): ( PubMed , DOI )

  7. Yuta Fujii, Lin Liu, Lisa Yagasaki, Maiko Inotsume, Tomoki Chiba, Hiroshi Asahara: Cartilage Homeostasis and Osteoarthritis. Int J Mol Sci. 2022.06; 23 (11): ( PubMed , DOI )

  1. Lin Liu, Hiroyuki Koike, Takehito Ono, Shinichiro Hayashi, Fujimi Kudo, Atsushi Kaneda, Hiroyuki Kagechika, Ichiro Manabe, Tomoki Nakashima, Yumiko Oishi: Identification of a KLF5-dependent program and drug development for skeletal muscle atrophy. Proc Natl Acad Sci U S A. 2021.08; 118 (35): ( PubMed , DOI )

  2. Yoshiaki Ito, Tokio Matsuzaki, Fumiaki Ayabe, Sho Mokuda, Ryota Kurimoto, Takahide Matsushima, Yusuke Tabata, Maiko Inotsume, Hiroki Tsutsumi, Lin Liu, Masahiro Shinohara, Yoko Tanaka, Ryo Nakamichi, Keiichiro Nishida, Martin K Lotz, Hiroshi Asahara: Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis. Nat Commun. 2021.07; 12 (1): 4148. ( PubMed , DOI )

  3. Atsuo Iida, Kaori Sano, Mayu Inokuchi, Jumpei Nomura, Takayuki Suzuki, Mao Kuriki, Maina Sogabe, Daichi Susaki, Kaoru Tonosaki, Tetsu Kinoshita, Eiichi Hondo: Cubam receptor-mediated endocytosis in hindgut-derived pseudoplacenta of a viviparous teleost (Xenotoca eiseni). J Exp Biol. 2021.07; 224 (13): ( PubMed , DOI )

  4. Iwasaki Toshio, Miyajima-Nakano Yoshiharu, Fukazawa Risako, Lin Myat T., Matsushita Shin-ichi, Hagiuda Emi, Taguchi Alexander T., Dikanov Sergei A., Oishi Yumiko, Gennis Robert B.: 蛋白質の構造機能相関を調査するための大腸菌アミノ酸要求性発現宿主株(Escherichia coli amino acid auxotrophic expression host strains for investigating protein structure-function relationships) The Journal of Biochemistry. 2021.04; 169 (4): 387-394. ( ichushi )

  5. Plasma and follicular fluid osteopontin levels during ovarian cycle and their correlation with follicular fluid vascular endothelial growth factor levels. 2021.01; 11 (1): 286. ( PubMed , DOI )

  1. Higuchi Tadashi, Yamaguchi Fumio, Asakura Takayuki, Yoshida Daizo, Oishi Yumiko, Morita Akio: 超音波は神経膠腫細胞において蛍光強度とアミノレブリン酸に対するABCG2 mRNA反応を調節する(Ultrasound Modulates Fluorescence Strength and ABCG2 mRNA Response to Aminolevulinic Acid in Glioma Cells) Journal of Nippon Medical School. 2020.12; 87 (6): 310-317. ( ichushi )

  2. Kitazawa M, Hayashi S, Imamura M, Takeda S, Oishi Y, Kaneko-Ishino T, Ishino F: Deficiency and overexpression of Rtl1 in the mouse cause distinct muscle abnormalities related to Temple and Kagami-Ogata syndromes. Development (Cambridge, England). 2020.09; 147 (21): ( PubMed , DOI )

  3. A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activation. 2020.06; 117 (25): 14365-14375. ( PubMed , DOI )

  4. Mao Kuriki, Fuminori Sato, Hiroyuki N Arai, Maina Sogabe, Mari Kaneko, Hiroshi Kiyonari, Koichi Kawakami, Yuki Yoshimoto, Chisa Shukunami, Atsuko Sehara-Fujisawa: Transient and lineage-restricted requirement of Ebf3 for sternum ossification. Development. 2020.05; 147 (9): ( PubMed , DOI )

  5. Signaling Pathways Potentially Responsible for Foam Cell Formation: Cholesterol Accumulation or Inflammatory Response-What is First? 2020.04; 21 (8): 2716. ( PubMed , DOI )

  6. Ultrasound modulates fluorescence strength and ABCG2 mRNA response to aminolevulinic acid in glioma cells. 2020.03; 87 (6): 310-317. ( PubMed , DOI )

  7. Role of Phagocytosis in the Pro-Inflammatory Response in LDL-Induced Foam Cell Formation; a Transcriptome Analysis. 2020.01; 21 (3): 817. ( PubMed , DOI )

  8. Organ System Crosstalk in Cardiometabolic Disease in the Age of Multimorbidity. 2020; 7 64. ( PubMed , DOI )

  1. Oishi Yumiko, Manabe Ichiro: 炎症、修復、再生におけるマクロファージ(Macrophages in inflammation, repair and regeneration) International Immunology. 2018.11; 30 (11): 511-528. ( ichushi )

  2. Macrophages in inflammation, repair and regeneration. 2018.10; 30 (11): 511-528. ( PubMed , DOI )

  3. Kentaro Katayama, Mao Kuriki, Tomoyo Kamiya, Yuki Tochigi, Hiroetsu Suzuki: Giantin is required for coordinated production of aggrecan, link protein and type XI collagen during chondrogenesis. Biochem Biophys Res Commun. 2018.05; 499 (3): 459-465. ( PubMed , DOI )

  4. Oishi Y, Manabe I: Krüppel-Like Factors in Metabolic Homeostasis and Cardiometabolic Disease. Frontiers in cardiovascular medicine. 2018; 5 69. ( PubMed , DOI )

  5. In vitro and in silico studies of the molecular interactions of epigallocatechin-3-o-gallate (egcg) with proteins that explain the health benefits of green tea 2018; 23 (6): ( PubMed , DOI )

  1. Yumiko Oishi, Shinichiro Hayashi, Takayuki Isagawa, Motohiko Oshima, Atsushi Iwama, Shigeki Shimba, Hitoshi Okamura, Ichiro Manabe: Bmal1 regulates inflammatory responses in macrophages by modulating enhancer RNA transcription. Sci Rep. 2017.08; 7 (1): 7086. ( PubMed , DOI )

  2. Yumiko Oishi, Nathanael J Spann, Verena M Link, Evan D Muse, Tobias Strid, Chantle Edillor, Matthew J Kolar, Takashi Matsuzaka, Sumio Hayakawa, Jenhan Tao, Minna U Kaikkonen, Aaron F Carlin, Michael T Lam, Ichiro Manabe, Hitoshi Shimano, Alan Saghatelian, Christopher K Glass: SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism. Cell Metab.. 2017.02; 25 (2): 412-427. ( PubMed , DOI )

  1. Shinichiro Hayashi, Ichiro Manabe, Yumi Suzuki, Frédéric Relaix, Yumiko Oishi: Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice. Elife. 2016.10; 5 ( PubMed , DOI )

  2. Yumiko Oishi, Ichiro Manabe: Macrophages in age-related chronic inflammatory diseases Aging and Mechanisms of Disease. 2016.07; 2 16018. ( DOI )

  3. Rumi Hachiya, Takuya Shiihashi, Ibuki Shirakawa, Yorihiro Iwasaki, Yoshihiro Matsumura, Yumiko Oishi, Yukiteru Nakayama, Yoshihiro Miyamoto, Ichiro Manabe, Kozue Ochi, Miyako Tanaka, Nobuhito Goda, Juro Sakai, Takayoshi Suganami, Yoshihiro Ogawa: The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages. Sci Rep. 2016.06; 6 28845. ( PubMed , DOI )

  4. Yumiko Oishi, Ichiro Manabe: Integrated regulation of the cellular metabolism and function of immune cells in adipose tissue. Clin. Exp. Pharmacol. Physiol.. 2016.03; 43 (3): 294-303. ( PubMed , DOI )

  5. Sumio Hayakawa, Kieko Saito, Noriyuki Miyoshi, Tomokazu Ohishi, Yumiko Oishi, Mamoru Miyoshi, Yoriyuki Nakamura: Anti-Cancer Effects of Green Tea by Either Anti- or Pro- Oxidative Mechanisms. Asian Pac. J. Cancer Prev.. 2016.03; 17 (4): 1649-1654. ( PubMed )

  1. Yumiko Oishi, Ichiro Manabe: Immunometabolic control of homeostasis and inflammation Inflammation and Regeneration. 2015.09; 35 (4): 185-192.

  1. 小池博之, 大石由美子: Vitamin A derivative inhibits KLF5 function in the skeletal muscle atrophy pathogenesis 実験医学. 2022.05; 40 (7): 1027-1031. ( ichushi )

  1. Yumiko Oishi, Ichiro Manabe: B cells in adipose tissue inflammation The Medical Frontline. 2016.11; 71 (917): 2217-2221.

  2. Yumiko Oishi, Ichiro Manabe: parabiosis in aging science Anti-Aging medicine. 2016.10; 12 (5): 650-656.

  3. Yumiko Oishi, Ichiro Manabe: Macrophage lineages in atherosclerosis Journal of Clinical and Experimental Medicine. 2016.10; 259 (5): 475-479.

  4. Yumiko Oishi, Ichiro Manabe: Zinc-finger transcription factors 2016.08; 175-180.

  5. Yumiko Oishi, Ichiro Manabe: Transcriptional, epigenetic, and transcriptome analysis of macrophage Journal of Clinical and Experimental Medicine. 2016.06; 257 (6): 733-737.

  6. Yumiko Oishi, Ichiro Manabe: Immune system in the organ crosstalk and metabolism Journal of Clinical and Experimental Medicine. 2016.05; 257 (6): 597-600.

  7. Yumiko Oishi, Ichiro Manabe: Chronic inflammation and atherosclerosis 2016.01; 45 (1): 12-17.

  1. Yumiko Oishi: Coordinated regulation of inflammatory response and cellular metabolism in macrophage Endocrinology, Diabetology & Metabolism. 2015.09; 41 (3): 230-234.

  1. Shigeru Matsuda, Yoshimitsu Kuwabara, Yoshitaka Taketomi, Yuki Nagasaki, Yosuke Sugita, Shunji Suzuki, Ichiro Manabe, Makoto Murakami, Yumiko Oishi: Impaired SREBP1-mediated regulation of lipid metabolism promotes inflammation in chronic endometritis Frontiers in Immunology. 2025.06; 16 ( DOI )

  1. Yumiko Oishi, Yahya Sohrabi, Peng Xiao: Metabolic regulation of macrophage functions in inflammation Frontiers in Immunology. 2024.02; 15 1369896. ( PubMed , DOI )

  2. Yumiko Oishi, Hiroyuki Koike, Naoki Kumagami, Yoshimi Nakagawa, Masaya Araki, Yoshitaka Taketomi, Yoshimi Miki, Shigeru Matsuda, Takashi Matsuzaka, Hitoshi Ozawa, Hitoshi Shimano, Makoto Murakami, Ichiro Manabe: Macrophage SREBP1 regulates skeletal muscle regeneration Frontiers in Immunology. 2024.01; 14 1251784-1382077. ( PubMed , DOI )

  3. 大石由美子: Muscle regeneration control by immune cells 医学のあゆみ. 2024; 289 (10):

  4. 新谷雄太郎, 早川清雄, 大倉定之, 田村篤志, 大石由美子, 佐藤卓: Intracellular cholesterol regulation contributes to the anti-HSV-1 activity 日本ウイルス学会学術集会プログラム・予稿集(Web). 2024; 71st

  5. 大石由美子, 大石由美子: Chronic inflammation in the pathogenesis of sarcopenia Bio Clinica. 2024;

  1. Yosuke Sugita, Yoshimitsu Kuwabara, Akira Katayama, Shigeru Matsuda, Ichiro Manabe, Shunji Suzuki, Yumiko Oishi: Characteristic impairment of progesterone response in cultured cervical fibroblasts obtained from patients with refractory cervical insufficiency Scientific Reports. 2023.07; 13 (1): ( DOI )

  2. Aiko Watanabe, Hiroyuki Koike, Naoki Kumagami, Shigeki Shimba, Ichiro Manabe, Yumiko Oishi: Arntl deficiency in myeloid cells reduces neutrophil recruitment and delays skeletal muscle repair Scientific Reports. 2023.04; 13 (1): 6747. ( PubMed , DOI )

  3. 大石由美子: Novel Atherosclerosis Treatment Targeting Intracellular Cholesterol Metabolism 日本分子生物学会年会プログラム・要旨集(Web). 2023; 46th

  1. Sumio Hayakawa, Tomokazu Ohishi, Yumiko Oishi, Mamoru Isemura, Noriyuki Miyoshi: Contribution of Non-Coding RNAs to Anticancer Effects of Dietary Polyphenols: Chlorogenic Acid, Curcumin, Epigallocatechin-3-Gallate, Genistein, Quercetin and Resveratrol Antioxidants. 2022.11; 11 (12): 2352. ( DOI )

  2. 吉本由紀, 大石由美子: Muscle disease and chronic inflammation 医学のあゆみ. 2022.07; 282 (1): 43-48.

  3. Ryo Yuzawa, Hiroyuki Koike, Ichiro Manabe, Yumiko Oishi: VDR regulates simulated microgravity-induced atrophy in C2C12 myotubes Scientific Reports. 2022.01; 12 (1): ( DOI )

  4. 大石由美子: Cellular Cholesterol Metabolism as a Novel Therapeutic Target of Atherosclerosis 日本循環器学会学術集会(Web). 2022; 86th

  5. 大石由美子: Interlellular network that operates muscle regeneration and repair 日本分子生物学会年会プログラム・要旨集(Web). 2022; 45th

  1. Toshio Iwasaki, Yoshiharu Miyajima-Nakano, Risako Fukazawa, Myat T Lin, Shin-ichi Matsushita, Emi Hagiuda, Alexander T Taguchi, Sergei A Dikanov, Yumiko Oishi, Robert B Gennis: Escherichia coli amino acid auxotrophic expression host strains for investigating protein structure–function relationships The Journal of Biochemistry. 2021.04; 169 (4): 387-394. ( DOI )

  2. 大石由美子, 小池博之: Diversity of skeletal muscle macrophages to lead regeneration and repair after muscle injury 日本分子生物学会年会プログラム・要旨集(Web). 2021; 44th

  3. 小池博之, 大石由美子: Single cell RNA sequence analysis for skeletal muscle tissue regeneration 医学のあゆみ. 2021; 276 (5):

  4. 高田賢, 小池博之, 佐藤日向, 大石由美子: SREBP1a in macrophage regulates tumor growth. 日本分子生物学会年会プログラム・要旨集(Web). 2021; 44th

  5. 大石由美子: How Diversity Makes Us Better, Smarter and Happier? 日本循環器学会学術集会(Web). 2021; 85th

  1. Sumio Hayakawa, Tomokazu Ohishi, Noriyuki Miyoshi, Yumiko Oishi, Yoriyuki Nakamura, Mamoru Isemura: Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid Molecules. 2020.10; 25 (19): 4553. ( DOI )

  1. 劉琳, 劉琳, 小池博之, 林晋一郎, 大石由美子, 淺原弘嗣: Zinc-finger transcription factor KLF5 is involved in the pathogenesis of muscle atrophy 日本筋学会学術集会プログラム・抄録集. 2019; 5th

  2. 成英瀾, 早川清雄, 大石由美子: Participation of inflammatory caspase to regulate cholesterol synthesis in macrophage 日本生化学会大会(Web). 2019; 92nd

  3. 大石由美子: Coordinated Regulation of Inflammatory Response and Lipid Metabolism in Macrophages 日本循環器学会学術集会(Web). 2019; 83rd

  1. Orekhov AN, Pushkarsky T, Oishi Y, Nikiforov NG, Zhelankin AV, Dubrovsky L, Makeev VJ, Foxx K, Jin X, Kruth HS, Sobenin IA, Sukhorukov VN, Zakiev ER, Kontush A, Le Goff W, Bukrinsky M: HDL activates expression of genes stimulating cholesterol efflux in human monocyte-derived macrophages. Experimental and molecular pathology. 2018.10; 105 (2): 202-207. ( PubMed , DOI )

  2. Orekhov AN, Oishi Y, Nikiforov NG, Zhelankin AV, Dubrovsky L, Sobenin IA, Kel A, Stelmashenko D, Makeev VJ, Foxx K, Jin X, Kruth HS, Bukrinsky M: Modified Ldl Particles Activate Inflammatory Pathways In Monocyte-Derived Macrophages: Transcriptome Analysis. Current pharmaceutical design. 2018; 24 (26): 3143-3151. ( PubMed , DOI )

  1. Oishi Y, Manabe I: [Adipose stem cell system.] Clinical calcium. 2017; 27 (6): 795-801. ( PubMed )

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