Department of Molecular Craniofacial Embryology and Oral Histology

121  articles.  
* There may be some overlapped articles listed due to the difference of format.

  1. Hiroyuki Koike, Miho Sugimura, Rie Ouchi, Yuki Yoshimoto, Ichiro Manabe, Yumiko Oishi: Macrophage Subpopulation Promotes Skeletal Muscle Regeneration Through HGF/MET Signaling-Mediated Skeletal Muscle Stem Cell Proliferation. Aging Cell. 2025.06; 24 (6): e70042. ( PubMed , DOI )

  2. Xinyi Yu, Ryosuke Kawakami, Shinsei Yambe, Yuki Yoshimoto, Takako Sasaki, Shinnosuke Higuchi, Hitomi Watanabe, Haruhiko Akiyama, Shigenori Miura, Kadi Hu, Gen Kondoh, Ramu Sagasaki, Masafumi Inui, Taiji Adachi, Denitsa Docheva, Takeshi Imamura, Chisa Shukunami: Dynamic interactions between cartilaginous and tendinous/ligamentous primordia during musculoskeletal integration. Development. 2025.03; 152 (6): ( PubMed , DOI )

  1. Kurosawa, T; Ikemoto-Uezumi, M; Yoshimoto, Y; Minato, K; Kaji, N; Chaen, T; Hase, E; Minamikawa, T; Yasui, T; Horiguchi, K; Iino, S; Hori, M; Uezumi, A: Tissue-specific functions of MSCs are linked to homeostatic muscle maintenance and alter with aging Aging Cell. 2024.11; 23 (11): e14299. ( PubMed , DOI )

  2. Hoshino Y, Liu S, Furutera T, Yamada T, Koyabu D, Nukada Y, Miyazawa M, Yoda T, Ichimura K, Iseki S, Tasaki J, Takechi M.: Pharmacological Inhibition of the Spliceosome SF3b Complex by Pladienolide-B Elicits Craniofacial Developmental Defects in Mouse and Zebrafish. Birth Defects Research. 2024.11; 116 (11): e2404. ( PubMed , DOI )

  3. Miyaki T, Homma N, Kawasaki Y, Kishi M, Yamaguchi J, Kakuta S, Shindo T, Sugiura M, Oliva Trejo JA, Kaneda H, Omotehara T, Takechi M, Negishi-Koga T, Ishijima M, Aoto K, Iseki S, Kitamura K, Muto S, Amagasa M, Hotchi S, Ogura K, Shibata S, Sakai T, Suzuki Y, Ichimura K: Ultrastructural analysis of whole glomeruli using array tomography Journal of Cell Science. 2024.10; 137 (20): jcs262154. ( PubMed , DOI )

  4. Yambe, S; Yoshimoto, Y; Ikeda, K; Maki, K; Takimoto, A; Tokuyama, A; Higuchi, S; Yu, XY; Uchibe, K; Miura, S; Watanabe, H; Sakuma, T; Yamamoto, T; Tanimoto, K; Kondoh, G; Kasahara, M; Mizoguchi, T; Docheva, D; Adachi, T; Shukunami, C: Sclerostin modulates mineralization degree and stiffness profile in the fibrocartilaginous enthesis for mechanical tissue integrity Frontiers in Cell and Developmental Biology. 2024.06; 12 1360041. ( PubMed , DOI )

  1. Fukuma Y, Tokunaga T, Tanimura S, Yoshimoto Y, Mashimo T, Kaneko T, Tian X, Ideo K, Yonemitsu R, Matsushita K, Sugimoto K, Yugami M, Hisanaga S, Nakamura T, Uehara Y, Masuda T, Shukunami C, Karasugi T, Miyamoto T: Potential function of Scx+/Sox9+ cells as progenitor cells in rotator cuff tear repair in rats. Biochemical and biophysical research communications. 2023.07; 676 84-90. ( PubMed , DOI )

  2. Yuki Yoshimoto, Yumiko Oishi: Mechanisms of skeletal muscle-tendon development and regeneration/healing as potential therapeutic targets. Pharmacol Ther. 2023.03; 243 108357. ( PubMed , DOI )

  3. Fuiten Allison M., Yoshimoto Yuki, Shukunami Chisa, Stadler H. Scott: Digits in a dish: An in vitro system to assess the molecular genetics of hand/foot development at single-cell resolution FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2023.03; 11 1135025. ( PubMed , DOI )

  4. Hoshino Yukiko, Takechi Masaki, Moazen Mehran, Steacy Miranda, Koyabu Daisuke, Furutera Toshiko, Ninomiya Youichirou, Nuri Takashi, Pauws Erwin, Iseki Sachiko: Synchondrosis fusion contributes to the progression of postnatal craniofacial dysmorphology in syndromic craniosynostosis JOURNAL OF ANATOMY. 2023.03; 242 (3): 387-401. ( DOI )

  5. Lou Yixin, Matsumoto Yoshiro, Iseki Sachiko, Ono Takashi: Difference in apical resorption activity during rat molar root formation in response to mechanical force EUROPEAN JOURNAL OF ORTHODONTICS. 2023.02; ( DOI )

  6. Yamazaki S, Hirayama R, Ikeda Y, Iseki S, Yoda T, Ikeda MA: Hyaluronic acid hydrogels support to generate integrated bone formation through endochondral ossification in vivo using mesenchymal stem cells. PloS one. 2023.02; 18 (2): e0281345. ( PubMed , DOI )

  7. Taro Nojiri, Ingmar Werneburg, Vuong Tan Tu, Dai Fukui, Masaki Takechi, Sachiko Iseki,Toshiko Furutera, Daisuke Koyabu: Timing of organogenesis underscores the evolution of neonatal life histories and powered flight in bats PROCEEDINGS OF THE ROYAL SOCIETY B . 2023.01; 290 20221928. ( PubMed , DOI )

  8. Namangkalakul W, Nagai S, Jin C, Nakahama KI, Yoshimoto Y, Ueha S, Akiyoshi K, Matsushima K, Nakashima T, Takechi M, Iseki S: Augmented effect of fibroblast growth factor 18 in bone morphogenetic protein 2-induced calvarial bone healing by activation of CCL2/CCR2 axis on M2 macrophage polarization. Journal of tissue engineering. 2023.01; 14 20417314231187960. ( PubMed , DOI )

  9. Kawakami J, Hisanaga S, Yoshimoto Y, Mashimo T, Kaneko T, Yoshimura N, Shimada M, Tateyama M, Matsunaga H, Shibata Y, Tanimura S, Takata K, Arima T, Maeda K, Fukuma Y, Uragami M, Ideo K, Sugimoto K, Yonemitsu R, Matsushita K, Yugami M, Uehara Y, Nakamura T, Tokunaga T, Karasugi T, Sueyoshi T, Shukunami C, Okamoto N, Masuda T, Miyamoto T: Remnant tissue enhances early postoperative biomechanical strength and infiltration of Scleraxis-positive cells within the grafted tendon in a rat anterior cruciate ligament reconstruction model. PloS one. 2023; 18 (11): e0293944. ( PubMed , DOI )

  1. Lu Zhao, Yoshiro Matsumoto, Sachiko Iseki, Takashi Ono: Effects of short-term orthodontic force application on the root at different developmental stages in rat maxillary molars Am J Orthod Dentofacial Orthop. 2022.12; 163 (4): 531-539.e2. ( PubMed , DOI )

  2. Kano Sakurako, Higashihori Norihisa, Thiha Phyo, Takechi Masaki, Iseki Sachiko, Moriyama Keiji: The role of the histone methyltransferase SET domain bifurcated 1 during palatal development BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2022.04; 598 74-80. ( DOI )

  3. Ikemoto-Uezumi M, Zhou H, Kurosawa T, Yoshimoto Y, Toyoda M, Kanazawa N, Nakazawa T, Morita M, Tsuchida K, Uezumi A: Increased MFG-E8 at neuromuscular junctions is an exacerbating factor for sarcopenia-associated denervation. Aging cell. 2022.01; 21 (1): e13536. ( PubMed , DOI )

  4. Nuri Takashi, Ota Masato, Ueda Koichi, Iseki Sachiko: Quantitative Morphologic Analysis of Cranial Vault in Twist1(+/-) Mice: Implications in Craniosynostosis PLASTIC AND RECONSTRUCTIVE SURGERY. 2022.01; 149 (1): 28E-37E. ( DOI )

  1. Keitaro Minato, Yuki Yoshimoto, Tamaki Kurosawa, Kei Watanabe, Hiroyuki Kawashima, Madoka Ikemoto-Uezumi, Akiyoshi Uezumi: Measurement of Lateral Transmission of Force in the Extensor Digitorum Longus Muscle of Young and Old Mice. Int J Mol Sci. 2021.11; 22 (22): ( PubMed , DOI )

  2. Masayoshi Kawatsu, Nobuo Takeshita, Aki Takimoto, Yuki Yoshimoto, Masahiro Seiryu, Arata Ito, Seiji Kimura, Tadafumi Kawamoto, Yuji Hiraki, Chisa Shukunami, Teruko Takano-Yamamoto: Scleraxis upregulated by transforming growth factor-β1 signaling inhibits tension-induced osteoblast differentiation of priodontal ligament cells via ephrin A2. Bone. 2021.08; 149 115969. ( PubMed , DOI )

  3. Saadat KASM, Lestari W, Pratama E, Ma T, Iseki S, Tatsumi M, Ikeda MA: Distinct and overlapping roles of ARID3A and ARID3B in regulating E2F‑dependent transcription via direct binding to E2F target genes. International journal of oncology. 2021.04; 58 (4): ( PubMed , DOI )

  4. Guo L, Iida A, Bhavani GS, Gowrishankar K, Wang Z, Xue J, Wang J, Miyake N, Matsumoto N, Hasegawa T, Iizuka Y, Matsuda M, Nakashima T, Takechi M, Iseki S, Yambe S, Nishimura G, Koseki H, Shukunami C, Girisha KM, Ikegawa S: Deficiency of TMEM53 causes a previously unknown sclerosing bone disorder by dysregulation of BMP-SMAD signaling. Nature Communications. 2021.04; 12 (1): 2046. ( PubMed , DOI )

  5. Takenoshita M, Takechi M (Co-first), Vu TH, Furutera T, Akagawa C, Namangkalakul W, Aoto K Kume T, Miyashin M, Iwamoto T, Iseki S: Cell lineage- and expression-based inference of the roles of forkhead box transcription factor Foxc2 in craniofacial development. Developmental Dynamics. 2021.03; ( PubMed , DOI )

  6. Akiyoshi Uezumi, Madoka Ikemoto-Uezumi, Heying Zhou, Tamaki Kurosawa, Yuki Yoshimoto, Masashi Nakatani, Keisuke Hitachi, Hisateru Yamaguchi, Shuji Wakatsuki, Toshiyuki Araki, Mitsuhiro Morita, Harumoto Yamada, Masashi Toyoda, Nobuo Kanazawa, Tatsu Nakazawa, Jun Hino, So-Ichiro Fukada, Kunihiro Tsuchida: Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia. J Clin Invest. 2021.01; 131 (1): ( PubMed , DOI )

  7. Vu TH, Takechi M (Co-first), Shimizu M, Kitazawa T, Higashiyama H, Iwase A, Kurihara H, Iseki S: Dlx5-augmentation in neural crest cells reveals early development and differentiation potential of mouse apical head mesenchyme. Scientific Reports. 2021.01; 11 (1): 2092. ( PubMed , DOI )

  1. Rajendan Arun Kumar, Arisaka Yoshinori, Yui Nobuhiko, Iseki Sachiko: Polyrotaxanes as emerging biomaterials for tissue engineering applications: a brief review INFLAMMATION AND REGENERATION. 2020.11; 40 (1): 27. ( PubMed , DOI )

  2. Rajendan Arun Kumar, Arisaka Yoshinori, Yui Nobuhiko, Iseki Sachiko: 組織工学応用のための注目されつつある生体医療材料としてのpolyrotaxane　簡易レビュー(Polyrotaxanes as emerging biomaterials for tissue engineering applications: a brief review) Inflammation and Regeneration. 2020.11; 40 1 of 8-8 of 8. ( ichushi )

  3. Rajendan Arun Kumar, Arisaka Yoshinori, Yui Nobuhiko, Iseki Sachiko: Polyrotaxanes as emerging biomaterials for tissue engineering applications: a brief review(和訳中) Inflammation and Regeneration. 2020.11; 40 1 of 8-8 of 8.

  4. Date Yuki, Kondo Hisatomo, Yamashita Atsuko, Iseki Sachiko, Kasugai Shohei, Ota Masato S.: Combined in silico analysis identified a putative tooth root formation-related gene, Chd3, which regulates DNA synthesis in HERS01a cells(和訳中) Odontology. 2020.07; 108 (3): 386-395. ( ichushi )

  5. Sanchez J, Miyake R, Cheng A, Liu T, Iseki S, Kume T. : Conditional inactivation of Foxc1 and Foxc2 in neural crest cells leads to cardiac abnormalities Genesis. 2020.07; 58 (7): e23364. ( DOI )

  6. Ohki S, Oka K, Ogata K, Okuhara S, Rikitake M, Toda-Nakamura M, Tamura S, Masao Ozaki, Iseki S, Sakai T. : Transforming Growth Factor-Beta and Sonic Hedgehog Signaling in Palatal Epithelium Regulate Tenascin-C Expression in Palatal Mesenchyme During Soft Palate Development Frontiers in Physiology. 2020.06; 11 532. ( DOI )

  7. Mao Kuriki, Fuminori Sato, Hiroyuki N Arai, Maina Sogabe, Mari Kaneko, Hiroshi Kiyonari, Koichi Kawakami, Yuki Yoshimoto, Chisa Shukunami, Atsuko Sehara-Fujisawa: Transient and lineage-restricted requirement of Ebf3 for sternum ossification. Development. 2020.05; 147 (9): ( PubMed , DOI )

  8. Yamada T, Takechi M, Yokoyama N, Hiraoka Y, Ishikubo H, Usami T, Furutera T, Taga Y, Hirate Y, Kanai-Azuma M, Yoda T, Ogawa-Goto K, Iseki S. : Heterozygous mutation of the splicing factor Sf3b4 affects development of the axial skeleton and forebrain in mouse. Developmental Dynamics. 2020.05; 249 (5): 622-635. ( DOI )

  9. Yuki Yoshimoto, Madoka Ikemoto-Uezumi, Keisuke Hitachi, So-Ichiro Fukada, Akiyoshi Uezumi: Methods for Accurate Assessment of Myofiber Maturity During Skeletal Muscle Regeneration. Front Cell Dev Biol. 2020; 8 267. ( PubMed , DOI )

  10. Katsumasa Ideo, Takuya Tokunaga, Chisa Shukunami, Aki Takimoto, Yuki Yoshimoto, Ryuji Yonemitsu, Tatsuki Karasugi, Hiroshi Mizuta, Yuji Hiraki, Takeshi Miyamoto: Role of Scx+/Sox9+ cells as potential progenitor cells for postnatal supraspinatus enthesis formation and healing after injury in mice. PLoS One. 2020; 15 (12): e0242286. ( PubMed , DOI )

  1. Shigeru Okuhara, Anahid A. Birjandi, Hadeel Adel Al-Lami, Tomoko Sagai, Takanori Amano, Toshihiko Shiroishi, Guilherme M. Xavier, Karen J. Liu, Martyn T. Cobourne, Sachiko Iseki: Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature Development. 2019.11; 146 (21): ( DOI )

  2. Hiroyuki N Arai, Fuminori Sato, Takuya Yamamoto, Knut Woltjen, Hiroshi Kiyonari, Yuki Yoshimoto, Chisa Shukunami, Haruhiko Akiyama, Ralf Kist, Atsuko Sehara-Fujisawa: Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate. Cell Rep. 2019.10; 29 (3): 603-616.e5. ( PubMed , DOI )

  3. Cobourne MT, Iseki S, Birjandi AA, Adel Al-Lami H, Thauvin-Robinet C, Xavier GM, Liu KJ.: How to make a tongue: Cellular and molecular regulation of muscle and connective tissue formation during mammalian tongue development. Semin. Cell Dev. Biol.. 2019.07; 91 45-54. ( DOI )

  4. Zhao L, Matsumoto Y, Ono T, Iseki S.: Effects of mechanical force application on the developing root apex in rat maxillary molars. Arch Oral Biol.. 2019.05; 101 64-76. ( DOI )

  5. Rajendran AK, Arisaka Y, Iseki S, Yui N. : Sulfonated Polyrotaxane Surfaces with Basic Fibroblast Growth Factor Alter the Osteogenic Potential of Human Mesenchymal Stem Cells in Short-Term Culture. ACS Biomater. Sci. Eng.. 2019.02; ( DOI )

  1. Mya, N., Furutera, T., Okuhara, S., Kume, T., Takechi, M., Iseki, S: Transcription factor Foxc1 is involved in anterior part of cranial base formation. Congenital Anomalies. 2018.09; 58 (5): 158-166. ( PubMed , DOI )

  2. Charoenlarp, P, Rajendrana, AK, Fujihara, R, Kojima T, Nakahama K, Sasaki, Y, Akiyoshi K, Takechi M, Iseki S: The improvement of calvarial bone healing by durable nanogel-crosslinked materials Journal of Biomaterials Science, Polymer Edition. 2018.08; ( PubMed , DOI )

  3. Fujiwara N, Lee JW, Kumakami-Sakano M, Otsu K, Woo JT, Iseki S, Ota MS.: Harmine promotes molar root development via SMAD1/5/8 phosphorylation. Biochem. Biophys. Res. Commun.. 2018.03; 497 (3): 924-929. ( DOI )

  4. Chisa Shukunami, Aki Takimoto, Yuriko Nishizaki, Yuki Yoshimoto, Seima Tanaka, Shigenori Miura, Hitomi Watanabe, Tetsushi Sakuma, Takashi Yamamoto, Gen Kondoh, Yuji Hiraki: Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes. Sci Rep. 2018.02; 8 (1): 3155. ( PubMed , DOI )

  5. Ota MS, Kondo K, Li Y, Iseki S, Yamashita A, Gibson CW, Kondo T.: Amelogenin X impacts age-dependent increase of frequency and number in labial incisor grooves in C57BL/6. Biochem. Biophys. Res. Commun.. 2018.02; 496 (2): 324-327. ( DOI )

  1. Sivashanmugam A, Charoenlarp P, Deepthi S, Rajendran A, Nair SV, Iseki S, Jayakumar R.: Injectable Shear-Thinning CaSO4/FGF-18-Incorporated Chitin-PLGA Hydrogel Enhances Bone Regeneration in Mice Cranial Bone Defect Model. ACS Appl Mater Interfaces. ACS Applied Materials & Interfaces. 2017.12; 9 (49): 42639-42652.

  2. Furutera, T., Takechi, M. (Co-first, Corresponding author), Kitazawa, T., Takei, J., Yamada, T., Vu Hoang, T., Rijli, F. M., Kurihara, H., Kuratani, S., Iseki, S.: Differing contributions of the first and second pharyngeal arches to tympanic membrane formation in the mouse and chick. Development. 2017.09; 144 (18): 3315-3324. ( PubMed , DOI )

  3. Charoenlarp P., Arun Kumar R., Iseki S.: Role of Fibroblast Growth Factors in bone regeneration. Inflammation and Regeneration. 2017.08; 37 10. ( DOI )

  4. Yuki Yoshimoto, Aki Takimoto, Hitomi Watanabe, Yuji Hiraki, Gen Kondoh, Chisa Shukunami: Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system. Sci Rep. 2017.03; 7 45010. ( PubMed , DOI )

  5. Kriangkrai R., Chareonvit S., Iseki S., Limwonge V.: Pretreatment Effect of Folic Acid on 13-Cis-RA-Induced Cellular Damage of Developing Midfacial Processes in Cultured Rat Embryos. The Open Dentistry Journal . 2017.03; 11 200-221. ( DOI )

  6. Amin M.B., Miura M. Uddin M.K., Islam M.J., Yoshida N., Iseki S., Kume T. Trainor P.A., Saitsu H. Kazushi Aoto.: Foxc2CreERT2 knock-in mice mark stage-specific Foxc2-expressing cells during mouse organogenesis. Congenital Anomalies. 2017.01; 57 (1): 24-31.

  1. Otsuki Y., Ueda K., Satoh C., Maekawa R., Yoshiura K., Iseki S.: Intermediate phenotype between ADULT syndrome and EEC syndrome caused by R243Q mutation in TP63 Plastic and Reconstructive Surgery-Global Open. 2016.12; 4 (12): e1185.

  2. Chisa Shukunami, Yuki Yoshimoto, Aki Takimoto, Hiroshi Yamashita, Yuji Hiraki: Molecular characterization and function of tenomodulin, a marker of tendons and ligaments that integrate musculoskeletal components. Jpn Dent Sci Rev. 2016.11; 52 (4): 84-92. ( PubMed , DOI )

  3. Takechi, M., Kitazawa, T., Hirasawa, T., Hirai, T., Iseki, S., Kurihara, H., Kuratani, S.: Developmental mechanisms of the tympanic membrane in mammals and non-mammalian amniotes. Congenital Anomalies. 2016.01; 56 (1): 12-17. ( PubMed , DOI )

  1. Min Cui, Soshi Kanemoto, Xiang Cui, Masayuki Kaneko, Rie Asada, Koji Matsuhisa, Keiji Tanimoto, Yuki Yoshimoto, Chisa Shukunami, Kazunori Imaizumi: OASIS modulates hypoxia pathway activity to regulate bone angiogenesis. Sci Rep. 2015.11; 5 16455. ( PubMed , DOI )

  2. Thanit Prasitsak, Mya Nandar, Shigeru Okuhara, Shizuko Ichinose, Masato S Ota, Sachiko Iseki: Foxc1 is required for early stage telencephalic vascular development. Dev. Dyn.. 2015.05; 244 (5): 703-711. ( PubMed , DOI )

  3. R Arun Kumar, A Sivashanmugam, S Deepthi, Sachiko Iseki, K P Chennazhi, Shantikumar V Nair, R Jayakumar: Injectable Chitin-Poly(ε-caprolactone)/Nanohydroxyapatite Composite Microgels Prepared by Simple Regeneration Technique for Bone Tissue Engineering. ACS Appl Mater Interfaces. 2015.05; 7 (18): 9399-9409. ( PubMed , DOI )

  4. Aki Takimoto, Masayoshi Kawatsu, Yuki Yoshimoto, Tadafumi Kawamoto, Masahiro Seiryu, Teruko Takano-Yamamoto, Yuji Hiraki, Chisa Shukunami: Scleraxis and osterix antagonistically regulate tensile force-responsive remodeling of the periodontal ligament and alveolar bone. Development. 2015.02; 142 (4): 787-796. ( PubMed , DOI )

  5. Michiko Yoshida, Kenji Hata, Rikako Takashima, Koichiro Ono, Eriko Nakamura, Yoshifumi Takahata, Tomohiko Murakami, Sachiko Iseki, Teruko Takano-Yamamoto, Riko Nishimura, Toshiyuki Yoneda: The transcription factor Foxc1 is necessary for Ihh-Gli2-regulated endochondral ossification. Nat Commun. 2015; 6 6653. ( PubMed , DOI )

  1. Sox9-and scleraxis-cre lineage fate mapping in aortic and mitral valve structures 2014.09; 1 (2): 163-176. ( DOI )

  2. Akihiko Machida, Shigeru Okuhara, Kiyoshi Harada, Sachiko Iseki: Difference in apical and basal growth of the frontal bone primordium in Foxc1ch/ch mice. Congenit Anom (Kyoto). 2014.08; 54 (3): 172-177. ( PubMed , DOI )

  1. Yoko Kameda, Takayoshi Saitoh, Noriko Nemoto, Tokio Katoh, Sachiko Iseki, Takao Fujimura: Hes1 is required for the development of pharyngeal organs and survival of neural crest-derived mesenchymal cells in pharyngeal arches. Cell Tissue Res.. 2013.07; 353 (1): 9-25. ( PubMed , DOI )

  2. Yuki Sugimoto, Aki Takimoto, Haruhiko Akiyama, Ralf Kist, Gerd Scherer, Takashi Nakamura, Yuji Hiraki, Chisa Shukunami: Scx+/Sox9+ progenitors contribute to the establishment of the junction between cartilage and tendon/ligament. Development. 2013.06; 140 (11): 2280-2288. ( PubMed , DOI )

  3. Tomoko Nagayama, Shigeru Okuhara, Masato S Ota, Noriko Tachikawa, Shohei Kasugai, Sachiko Iseki: FGF18 accelerates osteoblast differentiation by upregulating Bmp2 expression. Congenit Anom (Kyoto). 2013.06; 53 (2): 83-88. ( PubMed , DOI )

  4. Yuki Sugimoto, Aki Takimoto, Yuji Hiraki, Chisa Shukunami: Generation and characterization of ScxCre transgenic mice. Genesis. 2013.04; 51 (4): 275-283. ( PubMed , DOI )

  1. A Oshiro, S Iseki, M Miyauchi, T Terashima, Y Kawaguchi, Y Ikeda, T Shinomura: Lipopolysaccharide induces rapid loss of follicular dendritic cell-secreted protein in the junctional epithelium. J. Periodont. Res.. 2012.12; 47 (6): 689-694. ( PubMed , DOI )

  2. Fujioka-Kobayashi Masako, Ota Masato S, Shimoda Asako, Nakahama Ken-ichi, Akiyoshi Kazunari, Miyamoto Youji, Iseki Sachiko: Cholesteryl group- and acryloyl group-bearing pullulan nanogel to deliver BMP2 and FGF18 for bone tissue engineering. Biomaterials. 2012.10; 33 (30): 7613-7620. ( PubMed , DOI )

  3. Hiroyuki Suzuki, Naoto Suda, Momotoshi Shiga, Yukiho Kobayashi, Masataka Nakamura, Sachiko Iseki, Keiji Moriyama: Apert syndrome mutant FGFR2 and its soluble form reciprocally alter osteogenesis of primary calvarial osteoblasts. J. Cell. Physiol.. 2012.09; 227 (9): 3267-3277. ( PubMed , DOI )

  4. Yoko Kameda, Takayoshi Saitoh, Noriko Nemoto, Tokio Katoh, Sachiko Iseki: Hes1 is required for the development of the superior cervical ganglion of sympathetic trunk and the carotid body. Dev. Dyn.. 2012.08; 241 (8): 1289-1300. ( PubMed , DOI )

  5. Atsuko Taki, Mayumi Abe, Motohiro Komaki, Kikuko Oku, Sachiko Iseki, Shuki Mizutani, Ikuo Morita: Expression of angiogenesis-related factors and inflammatory cytokines in placenta and umbilical vessels in pregnancies with preeclampsia and chorioamnionitis/funisitis. Congenit Anom (Kyoto). 2012.06; 52 (2): 97-103. ( PubMed , DOI )

  6. Y Date, Y Yokoyama, H Kondo, S Kuroda, K Ohya, M S Ota, S Iseki, S Kasugai: Restricted expression of chromatin remodeling associated factor Chd3 during tooth root development. J. Periodont. Res.. 2012.04; 47 (2): 180-187. ( PubMed , DOI )

  7. Ryosuke Nagaoka, Shigeru Okuhara, Yutaka Sato, Teruo Amagasa, Sachiko Iseki: Effects of embryonic hypoxia on lip formation. Birth Defects Res. Part A Clin. Mol. Teratol.. 2012.04; 94 (4): 215-222. ( PubMed , DOI )

  8. Teng Ma, Shumpei Yamada, Solachuddin J A Ichwan, Sachiko Iseki, Kiyoshi Ohtani, Megumi Otsu, Masa-Aki Ikeda: Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient in p53Ser46 phosphorylation. Biochem. Biophys. Res. Commun.. 2012.01; 417 (3): 931-937. ( PubMed , DOI )

  9. Widya Lestari, Solachuddin J A Ichwan, Megumi Otsu, Shumpei Yamada, Sachiko Iseki, Shihoko Shimizu, Masa-Aki Ikeda: Cooperation between ARID3A and p53 in the transcriptional activation of p21WAF1 in response to DNA damage. Biochem. Biophys. Res. Commun.. 2012.01; 417 (2): 710-716. ( PubMed , DOI )

  1. Sachiko Iseki: Disintegration of the medial epithelial seam: is cell death important in palatogenesis? Dev. Growth Differ.. 2011.02; 53 (2): 259-268. ( PubMed , DOI )

  2. N Ebe, M Hara-Yokoyama, K Iwasaki, S Iseki, S Okuhara, K A Podyma-Inoue, K Terasawa, A Watanabe, T Akizuki, H Watanabe, M Yanagishita, Y Izumi: Pocket epithelium in the pathological setting for HMGB1 release. J. Dent. Res.. 2011.02; 90 (2): 235-240. ( PubMed , DOI )

  3. Okuhara S., Iseki S.: Epithelial integrity in palatal shelf elevation. Japanese Dental Science Review . 2011; 48 (1): 18-22.

  1. Noriaki Shimada, Kyoko Ohno-Matsui, Sachiko Iseki, Masato Koike, Yasuo Uchiyama, Jiying Wang, Takeshi Yoshida, Tetsuji Sato, Christoph Peters, Manabu Mochizuki, Ikuo Morita: Cathepsin L in bone marrow-derived cells is required for retinal and choroidal neovascularization. Am. J. Pathol.. 2010.05; 176 (5): 2571-2580. ( PubMed , DOI )

  2. Ayako Kimura, Hiroyuki Inose, Fumiko Yano, Koji Fujita, Toshiyuki Ikeda, Shingo Sato, Makiko Iwasaki, Tetsuya Jinno, Keisuke Ae, Seiji Fukumoto, Yasuhiro Takeuchi, Hiroshi Itoh, Takeshi Imamura, Hiroshi Kawaguchi, Ung-il Chung, James F Martin, Sachiko Iseki, Ken-ichi Shinomiya, Shu Takeda: Runx1 and Runx2 cooperate during sternal morphogenesis. Development. 2010.04; 137 (7): 1159-1167. ( PubMed , DOI )

  1. Ayako Mikura, Shigeru Okuhara, Masahiro Saito, Masato Ota, Koichi Ueda, Sachiko Iseki: Association of tenascin-W expression with mineralization in mouse calvarial development. Congenit Anom (Kyoto). 2009.06; 49 (2): 77-84. ( PubMed , DOI )

  2. Kazuto Yamanokuchi, Akira Yabuki, Yuki Yoshimoto, Ko Arai, Makoto Fujiki, Kazuhiro Misumi: Gene and protein expression of cartilage oligomeric matrix protein associated with oncogenesis in canine tumors. J Vet Med Sci. 2009.04; 71 (4): 499-503. ( PubMed , DOI )

  3. Mima Shikanai, Kinji Asahina, Sachiko Iseki, Kenichi Teramoto, Tomohiro Nishida, Keiko Shimizu-Saito, Masato Ota, Kazuhiro Eto, Hirobumi Teraoka: A novel method of mouse ex utero transplantation of hepatic progenitor cells into the fetal liver. Biochem. Biophys. Res. Commun.. 2009.04; 381 (2): 276-282. ( PubMed , DOI )

  4. Masayo Harada, Hirotaka Murakami, Akihiko Okawa, Noriaki Okimoto, Shuichi Hiraoka, Taka Nakahara, Ryogo Akasaka, Yo-Ichi Shiraishi, Noriyuki Futatsugi, Yoko Mizutani-Koseki, Atsushi Kuroiwa, Mikako Shirouzu, Shigeyuki Yokoyama, Makoto Taiji, Sachiko Iseki, David M Ornitz, Haruhiko Koseki: FGF9 monomer-dimer equilibrium regulates extracellular matrix affinity and tissue diffusion. Nat. Genet.. 2009.03; 41 (3): 289-298. ( PubMed , DOI )

  5. Ozono E, Komori H, Iwanaga R, Ikeda MA, Iseki S, Ohtani K: E2F-like elements in p27(Kip1) promoter specifically sense deregulated E2F activity. Genes Cells. 2009.01; 14 (1): 89-99. ( PubMed , DOI )

  1. B McBratney-Owen, S Iseki, S D Bamforth, B R Olsen, G M Morriss-Kay: Development and tissue origins of the mammalian cranial base. Dev. Biol.. 2008.10; 322 (1): 121-132. ( PubMed , DOI )

  2. Toshiyuki Yoshida, Philaiporn Vivatbutsiri, Gillian Morriss-Kay, Yumiko Saga, Sachiko Iseki: Cell lineage in mammalian craniofacial mesenchyme. Mech. Dev.. 2008.09; 125 (9-10): 797-808. ( PubMed , DOI )

  3. Philaiporn Vivatbutsiri, Shizuko Ichinose, Marjo Hytönen, Kirsi Sainio, Kazuhiro Eto, Sachiko Iseki: Impaired meningeal development in association with apical expansion of calvarial bone osteogenesis in the Foxc1 mutant. J. Anat.. 2008.05; 212 (5): 603-611. ( PubMed , DOI )

  4. Eleni Hjiantoniou, Mustafa Anayasa, Paschalis Nicolaou, Ioannis Bantounas, Masahiro Saito, Sachiko Iseki, James B Uney, Leonidas A Phylactou: Twist induces reversal of myotube formation. Differentiation. 2008.02; 76 (2): 182-192. ( PubMed , DOI )

  5. Ariko Kojima, Ken-Ichi Nakahama, Kyoko Ohno-Matsui, Noriaki Shimada, Keisuke Mori, Sachiko Iseki, Tetsuji Sato, Manabu Mochizuki, Ikuo Morita: Connexin 43 contributes to differentiation of retinal pigment epithelial cells via cyclic AMP signaling. Biochem. Biophys. Res. Commun.. 2008.02; 366 (2): 532-538. ( PubMed , DOI )

  1. Sachiko Iseki, Masako Ishii-Suzuki, Naoko Tsunekawa, Yoko Yamada, Kazuhiro Eto, Kunihiko Obata: Experimental induction of palate shelf elevation in glutamate decarboxylase 67-deficient mice with cleft palate due to vertically oriented palatal shelf. Birth Defects Res. Part A Clin. Mol. Teratol.. 2007.10; 79 (10): 688-695. ( PubMed , DOI )

  2. Yoko Kameda, Toshiyuki Nishimaki, Osamu Chisaka, Sachiko Iseki, Henry M Sucov: Expression of the epithelial marker E-cadherin by thyroid C cells and their precursors during murine development. J. Histochem. Cytochem.. 2007.10; 55 (10): 1075-1088. ( PubMed , DOI )

  3. T Yokoi, M Saito, T Kiyono, S Iseki, K Kosaka, E Nishida, T Tsubakimoto, H Harada, K Eto, T Noguchi, T Teranaka: Establishment of immortalized dental follicle cells for generating periodontal ligament in vivo. Cell Tissue Res.. 2007.02; 327 (2): 301-311. ( PubMed , DOI )

  1. Masayuki Tanaka, Shinichi Okudaira, Yasuhiro Kishi, Ryunosuke Ohkawa, Sachiko Iseki, Masato Ota, Sumihare Noji, Yutaka Yatomi, Junken Aoki, Hiroyuki Arai: Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid. J. Biol. Chem.. 2006.09; 281 (35): 25822-25830. ( PubMed , DOI )

  2. Rungarun Kriangkrai, Suconta Chareonvit, Koichi Yahagi, Michio Fujiwara, Kazuhiro Eto, Sachiko Iseki: Study of Pax6 mutant rat revealed the association between upper incisor formation and midface formation. Dev. Dyn.. 2006.08; 235 (8): 2134-2143. ( PubMed , DOI )

  3. Rungarun Kriangkrai, Sachiko Iseki, Kazuhiro Eto, Suconta Chareonvit: Dual odontogenic origins develop at the early stage of rat maxillary incisor development. Anat. Embryol.. 2006.03; 211 (2): 101-108. ( PubMed , DOI )

  1. Sayaka Nakamura, Tatsuo Terashima, Toshiyuki Yoshida, Sachiko Iseki, Yoshiro Takano, Isao Ishikawa, Tamayuki Shinomura: Identification of genes preferentially expressed in periodontal ligament: specific expression of a novel secreted protein, FDC-SP. Biochem. Biophys. Res. Commun.. 2005.12; 338 (2): 1197-1203. ( PubMed , DOI )

  2. Toshiyuki Yoshida, Leonidas A Phylactou, James B Uney, Isao Ishikawa, Kazuhiro Eto, Sachiko Iseki: Twist is required for establishment of the mouse coronal suture. J. Anat.. 2005.05; 206 (5): 437-444. ( PubMed , DOI )

  3. Bantounas I, Glover CP, Kelly S, Iseki S, Phylactou LA, Uney JB: Assessing adenoviral hammerhead ribozyme and small hairpin RNA cassettes in neurons: inhibition of endogenous caspase-3 activity and protection from apoptotic cell death. J Neurosci Res. 2005.03; 79 (5): 661-669. ( PubMed , DOI )

  1. Asami-Miyagishi R, Iseki S, Usui M, Uchida K, Kubo H, Morita I: Expression and function of PPARgamma in rat placental development. Biochem Biophys Res Commun. 2004.03; 315 (2): 497-501. ( PubMed , DOI )

  1. Fujino M, Osumi N, Ninomiya Y, Iseki S, Shibasaki Y, Eto K: Disappearance of epidermal growth factor receptor is essential in the fusion of the nasal epithelium. Anat Sci Int. 2003.03; 78 (1): 25-35. ( PubMed , DOI )

  2. Hjiantoniou E, Iseki S, Uney JB, Phylactou LA: DNazyme-mediated cleavage of Twist transcripts and increase in cellular apoptosis. Biochem Biophys Res Commun. 2003.01; 300 (1): 178-181. ( PubMed )

  1. Kubota K, Iseki S, Kuroda S, Oida S, Iimura T, Duarte WR, Ohya K, Ishikawa I, Kasugai S: Synergistic effect of fibroblast growth factor-4 in ectopic bone formation induced by bone morphogenetic protein-2. Bone. 2002.10; 31 (4): 465-471. ( PubMed )

  2. Jiang X, Iseki S, Maxson RE, Sucov HM, Morriss-Kay GM: Tissue origins and interactions in the mammalian skull vault. Dev Biol. 2002.01; 241 (1): 106-116. ( PubMed , DOI )

  1. Hall M, Gofflot F, Iseki S, Morriss-Kay GM: Effects of the curly tail genotype on neuroepithelial integrity and cell proliferation during late stages of primary neurulation. J Anat. 2001.12; 199 (Pt 6): 645-655. ( PubMed )

  2. Morriss-Kay GM, Iseki S, Johnson D: Genetic control of the cell proliferation-differentiation balance in the developing skull vault: roles of fibroblast growth factor receptor signalling pathways. Novartis Found Symp. 2001; 232 102-16; discussion 116-21. ( PubMed )

  3. Iseki S., Morriss-Kay G.M. and Eto K. : Study of Fibroblast Growth Factor Receptor Signalling during Skull Vault Development by Ex-Utero Surgery. J . Hard Tissue Biology. 2001; (10): 25-29.

  1. Johnson D, Iseki S, Wilkie AO, Morriss-Kay GM: Expression patterns of Twist and Fgfr1, -2 and -3 in the developing mouse coronal suture suggest a key role for twist in suture initiation and biogenesis. Mech Dev. 2000.03; 91 (1-2): 341-345. ( PubMed )

  1. Iseki S, Wilkie AO, Morriss-Kay GM: Fgfr1 and Fgfr2 have distinct differentiation- and proliferation-related roles in the developing mouse skull vault. Development. 1999.12; 126 (24): 5611-5620. ( PubMed )

  2. Oldridge M, Zackai EH, McDonald-McGinn DM, Iseki S, Morriss-Kay GM, Twigg SR, Johnson D, Wall SA, Jiang W, Theda C, Jabs EW, Wilkie AO: De novo alu-element insertions in FGFR2 identify a distinct pathological basis for Apert syndrome. Am J Hum Genet. 1999.02; 64 (2): 446-461. ( PubMed , DOI )

  1. Iseki S, Wilkie AO, Heath JK, Ishimaru T, Eto K, Morriss-Kay GM: Fgfr2 and osteopontin domains in the developing skull vault are mutually exclusive and can be altered by locally applied FGF2. Development. 1997.09; 124 (17): 3375-3384. ( PubMed )

  2. Osumi-Yamashita N, Kuratani S, Ninomiya Y, Aoki K, Iseki S, Chareonvit S, Doi H, Fujiwara M, Watanabe T, Eto K: Cranial anomaly of homozygous rSey rat is associated with a defect in the migration pathway of midbrain crest cells. Dev Growth Differ. 1997.02; 39 (1): 53-67. ( PubMed )

  1. Koyama E, Yamaai T, Iseki S, Ohuchi H, Nohno T, Yoshioka H, Hayashi Y, Leatherman JL, Golden EB, Noji S, Pacifici M: Polarizing activity, Sonic hedgehog, and tooth development in embryonic and postnatal mouse. Dev Dyn. 1996.05; 206 (1): 59-72. ( PubMed , DOI )

  2. Iseki S, Araga A, Ohuchi H, Nohno T, Yoshioka H, Hayashi F, Noji S: Sonic hedgehog is expressed in epithelial cells during development of whisker, hair, and tooth. Biochem Biophys Res Commun. 1996.01; 218 (3): 688-693. ( PubMed , DOI )

  1. Iseki S, Osumi-Yamashita N, Miyazono K, Franzen P, Ichijo H, Ohtani H, Hayashi Y, Eto K: Localization of transforming growth factor-beta type I and type II receptors in mouse development. Exp Cell Res. 1995.08; 219 (2): 339-347. ( PubMed , DOI )

  1. Matsuo T, Osumi-Yamashita N, Noji S, Ohuchi H, Koyama E, Myokai F, Matsuo N, Taniguchi S, Doi H, Iseki S, et al.: A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cells. Nat Genet. 1993.04; 3 (4): 299-304. ( PubMed , DOI )

  2. Iseki S: [Expression of glucocorticoid receptor gene during development of mouse embryos] Kokubyo Gakkai Zasshi. 1993.03; 60 (1): 66-80. ( PubMed )

  1. Osumi-Yamashita N., Iseki S., Noji S., Koyama E., Taniguchi S., Doi H. and Eto K. : Retinoic acid treatment induces the ectopic expression of retionoic acid receptor b and excessive cell death in the embryonic mouse face. Dev. Growth Differ. 1992; 34 (2): 199-209.

  1. Yuki Yoshimoto, Akiyoshi Uezumi, Madoka Ikemoto-Uezumi, Kaori Tanaka, Xinyi Yu, Tamaki Kurosawa, Shinsei Yambe, Kazumitsu Maehara, Yasuyuki Ohkawa, Yusuke Sotomaru, Chisa Shukunami: Tenogenic Induction From Induced Pluripotent Stem Cells Unveils the Trajectory Towards Tenocyte Differentiation. Frontiers in cell and developmental biology. 2022.03; 10 780038. ( PubMed , DOI )

  1. Shinsei Yambe, Yuki Yoshimoto, Kazutaka Ikeda, Koichiro Maki, Aki Takimoto, Shinnosuke Higuchi, Xinyi Yu, Kenta Uchibe, Shigenori Miura, Hitomi Watanabe, Tetsushi Sakuma, Takashi Yamamoto, Kotaro Tanimoto, Gen Kondoh, Denitsa Docheva, Taiji Adachi, Chisa Shukunami: Sclerostin modulates the degree of mineralization and the stiffness profile of the fibrocartilaginous enthesis for mechanical tissue integrity 2023.11; ( DOI )

  1. 上住円, 吉本由紀, 上住聡芳: The role of mesenchymal progenitor cells in maintenance of skeletal muscle 実験医学. 2020; 38 (16):

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