Bin Li, Natsuko Murakami, Cangyou Xie, Yuki Mouri, Hitomi Matsuno, Hisami Okawara, Kazuhiro Aoki, Noriyuki Wakabayashi: Effects of tensile and compressive stress on bone resorption and formation parameters surrounding dental implants Journal of the Mechanical Behavior of Biomedical Materials. 2025.02; 165 106928. ( DOI )
Involvement of metformin and aging in salivary expression of ACE2 and TMPRSS2. 2025; 51 (1): e2154. ( PubMed , DOI )
Kazutaka Nakamura, Masayuki Tsukasaki, Takaaki Tsunematsu, Minglu Yan, Yutaro Ando, Nam Cong-Nhat Huynh, Kyoko Hashimoto, Qiao Gou, Ryunosuke Muro, Ayumi Itabashi, Takahiro Iguchi, Kazuo Okamoto, Takashi Nakamura, Kenta Nakano, Tadashi Okamura, Tomoya Ueno, Kosei Ito, Naozumi Ishimaru, Kazuto Hoshi, Hiroshi Takayanagi: The periosteum provides a stromal defence against cancer invasion into the bone. Nature. 2024.10; 634 (8033): 474-481. ( PubMed , DOI )
Aota Keiko, Kani Koichi, Ono Shinji, Naniwa Kohei, Momota Yukihiro, Fukui Makoto, Ishimaru Naozumi, Azuma Masayuki: Activation of Janus kinase 2 contributes to the autoimmune pathology in the salivary glands of patients with Sjoegren's syndrome(タイトル和訳中) Oral Science International. 2024.09; 21 (3): 415-424. ( ichushi )
Hajime Tanaka, Yuki Fukawa, Kouhei Yamamoto, Kousuke Tanimoto, Akira Takemoto, Takayasu Mori, Hisashi Hasumi, Mayumi Kinoshita, Takumi Kanazawa, Asuka Furukawa, Koichiro Kimura, Hiroyuki Sato, Akihiro Hirakawa, Shohei Fukuda, Yuma Waseda, Soichiro Yoshida, Steven C Campbell, Yasuhisa Fujii: Prognostic impact and genomic backgrounds of renal parenchymal infiltration or micronodular spread in non-metastatic clear cell renal cell carcinoma. Mod Pathol. 2024.08; 100590. ( PubMed , DOI )
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Daishiro Kobayashi, Masaya Deda, Junya Hayashi, Kota Hidaka, Yutaka Kohmura, Takaaki Tsunematsu, Kohei Nishino, Harunori Yoshikawa, Kento Ohkawachi, Kiyomi Nigorikawa, Tetsuro Yoshimaru, Naozumi Ishimaru, Wataru Nomura, Toyomasa Katagiri, Hidetaka Kosako, Akira Otaka: Sulfoxide-Mediated Cys-Trp-Selective Bioconjugation that Enables Protein Labeling and Peptide Heterodimerization. Chem Eur. 2024.07; e202400014.
Herdiantoputri RR, Komura D, Ochi M, Fukawa Y, Kayamori K, Tsuchiya M, Kikuchi Y, Ushiku T, Ikeda T, Ishikawa S: Benchmarking Deep Learning-Based Image Retrieval of Oral Tumor Histology. Cureus. 2024.06; 16 (6): e62264. ( PubMed , DOI )
Akiko Yamada, Akira Watanabe, Atsushi Nara, Naozumi Ishimaru, Kosuke Maeda, Yusuke Ido, Kazumasa Kotake, Masatake Asano, Yasuo Shinohara, Takenori Yamamoto: Longitudinal Analysis of Mitochondrial Function in a Choline-Deficient L-Amino Acid-Defined High-Fat Diet-Induced Metabolic Dysfunction-Associated Steatohepatitis Mouse Model. Int J Mol Sci. 2024.06; 25 (11): ( PubMed , DOI )
Aya Ushio, Mami Matsuda-Lennikov, Felix Kalle-Youngoue, Akihide Shimizu, Abdalla Abdelmaksoud, Michael C Kelly, Naozumi Ishimaru, Yousuke Takahama: Functionally diverse thymic medullary epithelial cells interplay to direct central tolerance. Cell Rep. 2024.04; 43 (4): 114072. ( PubMed , DOI )
Hiroaki Tawara, Takaaki Tsunematsu, Shojiro Kitajima, Ruka Nagao, Shigefumi Matsuzawa, Kunihiro Otsuka, Aya Ushio, Naozumi Ishimaru: The noncanonical function of borealin, a component of chromosome passenger complex, promotes glycolysis via stabilization of survivin in squamous cell carcinoma cells. Biochem Biophys Res Commun. 2024.04; 706 149741. ( PubMed , DOI )
Keiko Aota, Koichi Kani, Shinji Ono, Kohei Naniwa, Yukihiro Momota, Makoto Fukui, Naozumi Ishimaru, Masayuki Azuma: Activation of Janus kinase 2 contributes to the autoimmune pathology in the salivary glands of patients with Sjögren's syndrome Oral Science International . 2024.03; (21): 415-424. ( DOI )
Iwasaki T, Harazono Y, Fukawa Y, Kaida A, Kayamori K, Sasaki Y, Harada H, Yoda T: Retrospective analysis of odontogenic myxoma and odontogenic myxofibroma in the oral and maxillofacial region: a fibrous tissue-related differentiation. The British journal of oral & maxillofacial surgery. 2024.02; 62 464-470. ( PubMed , DOI )
がん特殊化リボソームの同定と機能解析(Identification and characterization of cancer-specialized ribosomes) 2024.02; 113 (1): 295. ( ichushi )
シェーグレン症候群の病態形成に対するT細胞の共抑制性受容体の役割の解析(Analysis of the role of co-inhibitory receptors on T cells to the pathogenesis of Sjogren's syndrome) 2024.02; 113 (1): 297. ( ichushi )
Borealin-Survivin複合体は頭頸部扁平上皮癌の分化を直接的に制御する(Borealin-Survivin complex directly regulates keratinocyte differentiation in HNSCC) 2024.02; 113 (1): 296. ( ichushi )
多層カーボンナノチューブが免疫システムに及ぼす影響(The influence of multi-walled carbon nanotube for immune systems) 2024.02; 113 (1): 370. ( ichushi )
CRTC1::MAML2融合遺伝子の検出で確定診断に至った粘表皮癌の2例(Detection of the CRTC1::MAML2 fusion gene in two atypical cases of mucoepidermoid carcinoma) 2024.02; 113 (1): 346. ( ichushi )
Yosuke Harazono, Hiroyuki Yoshitake, Yuki Fukawa, Tohru Ikeda, Tetsuya Yoda: Osteoblastoma in the mandible of an older adult patient without FOS gene rearrangement: A case report and literature review Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2024.01;
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Naoya Kinoshita, Hideaki Hirai, Yuki Fukawa, Yuko Yamagata, Yoshihisa Kashima, Masaru Sato, Tohru Ikeda, Hiroyuki Harada.: A case of dentinogenic ghost cell tumor of the mandible with a review of the literature Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2023.11; 35 (6): 545-549. ( ichushi )
Sugimoto A, Iwata K, Kurogoushi R, Tanaka M, Nakashima Y, Yamakawa Y, Oishi A, Yoshizaki K, Fukumoto S, Yamamoto A, Ishimaru N, Iwamoto T: C-terminus of PIEZO1 governs Ca(2+) influx and intracellular ERK1/2 signaling pathway in mechanotransduction. Biochemical and biophysical research communications. 2023.11; 682 39-45. ( PubMed , DOI )
Involvement of the OTUB1-YAP1 axis in driving malignant behaviors of head and neck squamous cell carcinoma. 2023.11; 12 (24): 22156-22169. ( PubMed , DOI )
頭頸部扁平上皮癌(HNSCC)の進行における脱ユビキチン化酵素OTUB1の役割(The role of deubiquitinating enzyme, OTUB1 in head and neck squamous cell carcinoma(HNSCC) progression) 2023.09; 82回 1084. ( ichushi )
Shiori Watabe, Yukari Aruga, Ryoko Kato, Genji Kawade, Yuki Kubo, Anna Tatsuzawa, Iichiroh Onishi, Yuko Kinowaki, Sachiko Ishibashi, Masumi Ikeda, Yuki Fukawa, Keiichi Akahoshi, Minoru Tanabe, Morito Kurata, Kenichi Ohashi, Masanobu Kitagawa, Kouhei Yamamoto: Regulation of 4-HNE via SMARCA4 Is Associated with Worse Clinical Outcomes in Hepatocellular Carcinoma. Biomedicines. 2023.08; 11 (8): ( PubMed , DOI )
CD4+ T-cell-dependent differentiation of CD23+ follicular B cells contributes to the pulmonary pathology in a primary Sjögren’s syndrome mouse model 2023.07; 14 1217492. ( PubMed , DOI )
Cangyou Xie, Fatma Rashed, Yosuke Sasaki, Masud Khan, Jia Qi, Yuri Kubo, Yoshiro Matsumoto, Shinichi Sawada, Yoshihiro Sasaki, Takashi Ono, Tohru Ikeda, Kazunari Akiyoshi and Kazuhiro Aoki: Comparison of Osteoconductive Ability of Two Types of Cholesterol-Bearing Pullulan (CHP) Nanogel-Hydrogels Impregnated with BMP-2 and RANKL-Binding Peptide: Bone Histomorphometric Study in a Murine Calvarial Defect Model 2023.06; 24 (11): ( DOI )
シェーグレン症候群疾患モデルマウスにおけるMucin19の異常と病態との関連性の解析(Relation between Disfunction of Mucin 19 and Pathogenesis in a Mouse Model of Sjogren's Syndrome) 2023.03; 112 (1): 377. ( ichushi )
Anrizandy Narwidina, Aya Miyazaki, Kokoro Iwata, Rika Kurogoushi, Asuna Sugimoto, Yasusei Kudo, Keita Kawarabayashi, Yoshihito Yamakawa, Yuki Akazawa, Takamasa Kitamura, Hiroshi Nakagawa, Kimiko Yamaguchi-Ueda, Tomokazu Hasegawa, Keigo Yoshizaki, Satoshi Fukumoto, Akihito Yamamoto, Naozumi Ishimaru, Tomonori Iwasaki, Tsutomu Iwamoto: Iroquois homeobox 3 regulates odontoblast proliferation and differentiation mediated by Wnt5a expression. Biochem Biophys Res Commun. 2023.02; 650 47-54. ( PubMed , DOI )
Hajime Tanaka, Shohei Fukuda, Koichiro Kimura, Yuki Fukawa, Kouhei Yamamoto, Hiroshi Fukushima, Shingo Moriyama, Yosuke Yasuda, Sho Uehara, Yuma Waseda, Soichiro Yoshida, Minato Yokoyama, Yoh Matsuoka, Kazutaka Saito, Ukihide Tateishi, Steven C Campbell, Yasuhisa Fujii: Defining Tumour Shape Irregularity for Preoperative Risk Stratification of Clinically Localised Renal Cell Carcinoma. Eur Urol Open Sci. 2023.02; 48 36-43. ( PubMed , DOI )
Hata C, Fukawa Y, Motoi T, Kinowaki Y, Akashi T, Ohashi K, Ishikawa Y, Waseda Y, Fujii Y, Kakuta R, Ikeda S, Onishi I: A Primary Kidney Giant Cell Tumor of Soft Tissue Caused Peritoneal Dissemination, Considered to Be Malignant Transformation: A Case Report. Diagnostics (Basel, Switzerland). 2023.02; 13 (4): ( PubMed , DOI )
Yuki Fukawa, Kou Kayamori, Maiko Tsuchiya, Tohru Ikeda: IL-1 Generated by Oral Squamous Cell Carcinoma Stimulates Tumor-Induced and RANKL-Induced Osteoclastogenesis: A Possible Mechanism of Bone Resorption Induced by the Infiltration of Oral Squamous Cell Carcinoma. Int J Mol Sci. 2023.01; 24 (1): ( PubMed , DOI )
Cancer cell-derived novel periostin isoform promotes invasion in head and neck squamous cell carcinoma. 2023.01; 12 (7): 8510-8525. ( PubMed , DOI )
Kinoshita N, Tomioka H, Oikawa Y, Fukawa Y, Ikeda T, Harada H: A case of sclerosing odontogenic carcinoma of the mandible with a review of the literature. Journal of oral science. 2023; 65 (4): 281-283. ( PubMed , DOI )
Continuous infiltration of small peritoneal macrophages in the mouse peritoneum through CCR2-dependent and -independent routes during fibrosis and mesothelioma development induced by a multiwalled carbon nanotube, MWNT-7. 2023; 48 (12): 617-639. ( PubMed , DOI )
Short-chain fatty acids profiling in biological samples from a mouse model of Sjögren's syndrome based on derivatized LC-MS/MS assay. 2022.11; 1210 123432. ( PubMed , DOI )
Disturbed natural killer cell homeostasis in the salivary gland enhances autoimmune pathology via IFN-γ in a mouse model of primary Sjögren's syndrome. 2022.11; 9 1036787. ( PubMed , DOI )
脱ユビキチン化酵素OTUB1の頭頸部扁平上皮癌の進展における役割(The role of the deubiquitylating enzyme, OTUB1 in head and neck squamous cell carcinoma progression) 2022.09; 2022 165. ( ichushi )
Exposure to Multi-Wall Carbon Nanotubes Promotes Fibrous Proliferation by Production of Matrix Metalloproteinase-12 via NF-κB Activation in Chronic Peritonitis. 2022.08; 192 (11): 1559-1572. ( PubMed , DOI )
Xie Cangyou, Satake-Ozawa Michiko, Rashed Fatma, Khan Masud, Ikeda Masaomi, Hayashi Shunya, Sawada Shinichi, Sasaki Yoshihiro, Ikeda Tohru, Mori Yoshiyuki, Akiyoshi Kazunari, Aoki Kazuhiro: Perforated Hydrogels Consisting of Cholesterol-Bearing Pullulan (CHP) Nanogels: A Newly Designed Scaffold for Bone Regeneration Induced by RANKL-Binding Peptides and BMP-2 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022.07; 23 (14): 7768 (1)-7768 (15). ( PubMed , DOI )
Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren’s Syndrome 2022.07; 14 (7): 1474. ( PubMed , DOI )
Reversal of neuroinflammation in novel GS model mice by single i.c.v. administration of CHO-derived rhCTSA precursor protein. 2022.06; 25 297-310. ( PubMed , DOI )
The Priming Potential of Interferon Lambda-1 for Antiviral Defense in the Oral Mucosa. 2022.06; 45 (3): 1348-1361. ( PubMed , DOI )
Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity. 2022.05; 55 (5): 912-924. ( PubMed , DOI )
Terauchi Masahiko, Uo Motohiro, Fukawa Yuki, Yoshitake Hiroyuki, Tajima Rina, Ikeda Tohru, Yoda Tetsuya: Chemical Diagnosis of Calcium Pyrophosphate Deposition Disease of the Temporomandibular Joint: A Case Report DIAGNOSTICS. 2022.03; 12 (3): 651. ( PubMed , DOI )
PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity. 2022.03; 23 (3): 399-410. ( PubMed , DOI )
Kokoro Iwata, Keita Kawarabayashi, Keigo Yoshizaki, Tian Tian, Kan Saito, Asuna Sugimoto, Rika Kurogoushi, Aya Yamada, Akihito Yamamoto, Yasuei Kudo, Naozumi Ishimaru, Satoshi Fukumoto, Tsutomu Iwamoto: von Willebrand factor D and EGF domains regulate ameloblast differentiation and enamel formation Journal of Cellular Physiology. 2021.12; ( PubMed , DOI )
Conversion from epithelial to partial-EMT phenotype by Fusobacterium nucleatum infection promotes invasion of oral cancer cells 2021.12; 11 (1): 14943. ( PubMed , DOI )
ティーラウォン・チャンヤーヌット , 坂本 啓, 布川 裕規, 土谷 麻衣子, 栢森 高, 明石 巧, 濱垣 美和子, 富岡 博文, 黒嶋 雄志, 森田 圭一, 原田 浩之, 池田 通: 舌癌症例にみられるヒトパピローマウイルス(HPV)感染と無関係なp16免疫染色陽性反応(Immunohistochemical Positivity for p16 Unrelated to Human Papillomavirus(HPV) Infection in Lingual Squamous Cell Carcinomas) 口腔病学会雑誌. 2021.11; 88 (2-3): 115-126. ( ichushi )
Chen Shu, Tamaki Naofumi, Kudo Yasusei, Tsunematsu Takaaki, Miki Kaname, Ishimaru Naozumi, Ito Hiro-o: ヒト角化細胞における5-フルオロウラシル誘発性酸化ストレスおよび炎症反応に対するレスベラトロールの防御効果(Protective effects of resveratrol against 5-fluorouracil-induced oxidative stress and inflammatory responses in human keratinocytes) Journal of Clinical Biochemistry and Nutrition. 2021.11; 69 (3): 238-246. ( ichushi )
Protective effects of resveratrol against 5-fluorouracil-induced oxidative stress and inflammatory responses in human keratinocytes. 2021.11; 69 (3): 238-246. ( PubMed , DOI )
Shimada W, Tanaka H, Fukawa Y, Kimura K, Yamamoto K, Fukuda S, Fukushima H, Yasuda Y, Uehara S, Yoshida S, Yokoyama M, Matsuoka Y, Tateishi U, Campbell SC, Fujii Y: Infiltrative tumor interface with normal renal parenchyma in locally advanced renal cell carcinoma: Clinical relevance and pathological implications. International journal of urology : official journal of the Japanese Urological Association. 2021.08; 28 (12): 1233-1239. ( PubMed , DOI )
The life in Japan and status of private dental office at the times of COVID-19. 2021.04; 27 Suppl 3 (Suppl 3): 727-729. ( PubMed , DOI )
The thymoproteasome hardwires the TCR repertoire of CD8+ T cells in the cortex independent of negative selection. 2021.04; 218 (4): ( PubMed , DOI )
Yuki Fukawa, Kei Sakamoto, Takuma Kugimoto, Yasuyuki Michi, Hiroyuki Harada, Masahide Yamamoto, Masanobu Kitagawa, Tohru Ikeda, Kouhei Yamamoto: Nodular lymphocyte-predominant Hodgkin lymphoma involving the hard palate. Pathol Int. 2021.03; 71 (3): 213-215. ( PubMed , DOI )
Chemokines Up-Regulated in Epithelial Cells Control Senescence-Associated T Cell Accumulation in Salivary Glands of Aged and Sjögren's Syndrome Model Mice. 2021.02; 22 (5): ( PubMed , DOI )
頭頸部扁平上皮癌の予後を予測する新規システムの構築 2020.10; 79回 PJ14-2. ( ichushi )
Sento Shinya, Kudo Yasusei, Hibiya Kenji, Ishimaru Naozumi, Sasabe Eri, Kitamura Naoya, Yamamoto Tetsuya: 舌前方の唾液腺の硝子化明細胞癌 1症例報告と文献レビュー(Hyalinizing clear cell carcinoma of the anterior lingual salivary gland: A case report and review of the literature) Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2020.07; 32 (4): 267-274. ( ichushi )
Prognostic value of partial-EMT-related genes in head and neck squamous cell carcinoma by a bioinformatic analysis. 2020.04; ( PubMed , DOI )
Arakaki Rieko, Ushio Aya, Otsuka Kunihiro, Kudo Yasusei, Ishimaru Naozumi: マウスにおける少量の唾液を計測する新規方法(A novel method for measuring small amounts of saliva in mice) Oral Science International. 2019.12; 16 (3): 178-180. ( ichushi )
Otsuka K, Yamada A, Saito M, Ushio A, Sato M, Kisoda S, Shao W, Tsunematsu T, Kudo Y, Arakaki R, Ishimaru N: Achaete-Scute Homologue 2-Regulated Follicular Helper T Cells Promote Autoimmunity in a Murine Model for Sjögren Syndrome. The American journal of pathology. 2019.12; 189 (12): 2414-2427. ( PubMed , DOI )
A novel method for measuring small amounts of saliva in mice 2019.12; 16 (3): 178-180. ( DOI )
Yuyama K, Nakamura Y, Tateyama R, Arakaki R, Tsutsui T, Ishimaru N: Study of the pharmacokinetics of eriodictyol-6-C-β-d-glucoside, a flavonoid of rooibos (Aspalathus linearis) extract, after its oral administration in mice. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019.11; 1137 121881. ( PubMed , DOI )
Miyazaki A, Sugimoto A, Yoshizaki K, Kawarabayashi K, Iwata K, Kurogoushi R, Kitamura T, Otsuka K, Hasegawa T, Akazawa Y, Fukumoto S, Ishimaru N, Iwamoto T: Coordination of WNT signaling and ciliogenesis during odontogenesis by piezo type mechanosensitive ion channel component 1. Scientific reports. 2019.10; 9 (1): 14762. ( PubMed , DOI )
Shikama Y, Kurosawa M, Furukawa M, Ishimaru N, Matsushita K: Involvement of adiponectin in age-related increases in tear production in mice. Aging. 2019.10; 11 (19): 8329-8346. ( PubMed , DOI )
Arakaki Rieko, Ushio Aya, Kisoda Satoru, Sato Mami, Nakamura Yoshitaka, Yuyama Kanako, Tateyama Riho, Morishita Satoru, Monoi Noriyuki, Kudo Yasusei, Ishimaru Naozumi: マウスにおいて3型ムスカリン性アセチルコリン受容体を介した涙液分泌および唾液分泌に対するルイボス抽出物の新規作用(Novel effects of rooibos extract on tear and saliva secretion mediated by the muscarinic acetylcholine receptor 3 in mice) Journal of Oral Biosciences. 2019.09; 61 (3): 179-182. ( ichushi )
口腔癌におけるpartial EMTに関連する遺伝子の悪性度への関与(Involvement of partial EMT gene in malignant behavior of head and neck squamous cell carcinoma) 2019.09; 78回 J-1011. ( ichushi )
Arakaki R, Ushio A, Kisoda S, Sato M, Nakamura Y, Yuyama K, Tateyama R, Morishita S, Monoi N, Kudo Y, Ishimaru N: Novel effects of rooibos extract on tear and saliva secretion mediated by the muscarinic acetylcholine receptor 3 in mice. Journal of oral biosciences. 2019.09; 61 (3): 179-182. ( PubMed , DOI )
Nakatomi C, Nakatomi M, Matsubara T, Komori T, Doi-Inoue T, Ishimaru N, Weih F, Iwamoto T, Matsuda M, Kokabu S, Jimi E: Constitutive activation of the alternative NF-κB pathway disturbs endochondral ossification. Bone. 2019.04; 121 29-41. ( PubMed , DOI )
Otsuka Kunihiro, Yamada Akiko, Saito Masako, Ushio Aya, Tsunematsu Takaaki, Kisoda Satoru, Kudo Yasusei, Arakaki Rieko, Ishimaru Naozumi: 組織特異的免疫疾患 シェーグレン症候群マウスモデルの自己免疫における濾胞性ヘルパーT細胞の重要な役割(Tissue-specific immune diseases-2 A crucial role of follicular helper T cells in autoimmunity of a mouse model for Sjoegren's syndrome) 日本免疫学会総会・学術集会記録. 2018.12; 47 (Proceedings): 3-B. ( ichushi )
Ushio Aya, Arakaki Rieko, Otsuka Kunihiro, Yamada Akiko, Kudo Yasusei, Ishimaru Naozumi: 組織特異的免疫疾患 CCL22産生マクロファージはシェーグレン症候群の標的器官においてT細胞自己免疫を促進する(Tissue-specific immune diseases-2 CCL22-producing macrophages promote T cell autoimmunity in the target organ of Sjoegren's syndrome) 日本免疫学会総会・学術集会記録. 2018.12; 47 (Proceedings): 3-B. ( ichushi )
Aota K, Yamanoi T, Kani K, Nakashiro KI, Ishimaru N, Azuma M: Inverse correlation between the number of CXCR3+ macrophages and the severity of inflammatory lesions in Sjögren's syndrome salivary glands: A pilot study. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2018.08; 47 (7): 710-718. ( PubMed , DOI )
Invasion-Related Factors as Potential Diagnostic and Therapeutic Targets in Oral Squamous Cell Carcinoma-A Review. 2018.05; 19 (5): ( PubMed , DOI )
Distinct Regulation of CXCL10 Production by Cytokines in Human Salivary Gland Ductal and Acinar Cells 2018.03; 41 (4): 1-10. ( PubMed , DOI )
The microRNA-15a-PAI-2 axis in cholangiocarcinoma-associated fibroblasts promotes migration of cancer cells. 2018.01; 17 (1): 10. ( PubMed , DOI )
Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes. 2018; 13 (10): e0205702. ( PubMed , DOI )
Aurora Kinase Inhibitors in Head and Neck Cancer. 2018; 18 (3): 199-213. ( PubMed , DOI )
Ushio A, Arakaki R, Otsuka K, Yamada A, Tsunematsu T, Kudo Y, Aota K, Azuma M, Ishimaru N: CCL22-Producing Resident Macrophages Enhance T Cell Response in Sjögren's Syndrome. Frontiers in immunology. 2018; 9 2594. ( PubMed , DOI )
Contributions of CXCL12 and its receptor to the T cell autoimmune response in a Sjogren's syndrome murine model 2018; 36 (3): S299-S300.
井澤 俊, 新垣 理恵子, 田中 栄二, 石丸 直澄: 核内受容体AhRはRANK/c-Fosシグナル伝達経路を介して破骨細胞の分化を制御する 生命科学系学会合同年次大会. 2017.12; 2017年度 [2P-0943]. ( ichushi )
The nuclear receptor AhR controls bone homeostasis by regulating osteoclast differentiation via the RANK/c-Fos signaling axis 2017.12; 32 S346.
大東 いずみ, 石丸 直澄, 片貝 智哉, 高浜 洋介: T細胞の自己寛容性確立におけるCCL21の役割 生命科学系学会合同年次大会. 2017.12; 2017年度 [4P2T24-06(3P. ( ichushi )
Kurosawa M, Arakaki R, Yamada A, Tsunematsu T, Kudo Y, Sprent J, Ishimaru N: NF-κB2 Controls the Migratory Activity of Memory T Cells by Regulating Expression of CXCR4 in a Mouse Model of Sjögren's Syndrome. Arthritis & rheumatology (Hoboken, N.J.). 2017.11; 69 (11): 2193-2202. ( PubMed , DOI )
Preventive effects of mouthguard use while sleeping on recurrent aphthous stomatitis: Preliminary interventional study. 2017.10; 3 (5): 198-203. ( PubMed , DOI )
Mina Kozai, Yuki Kubo, Tomoya Katakai, Hiroyuki Kondo, Hiroshi Kiyonari, Karin Schaeuble, Sanjiv A. Luther, Naozumi Ishimaru, Izumi Ohigashi, Yousuke Takahama: Essential role of CCL21 in establishment of central self-tolerance in T cells The Journal of Experimental Medicine. 2017.07; Vol.214 (No.7): 1925-1935. ( PubMed , DOI )
Izawa T, author, Corresponding author, Arakaki R, Ishimaru N: Role of Fas and RANKL signaling in peripheral immune tolerance Journal of Clinical & Cellular Immunology. 2017.07; 8 (4): 512. ( DOI )
Establishment and characterization of a clear cell odontogenic carcinoma cell line with EWSR1-ATF1 fusion gene 2017.06; 69 46-55. ( PubMed , DOI )
Yamada Koichi, Arakaki Rieko, Yamada Akiko, Kudo Yasusei, Ishimaru Naozumi: 妊娠中のマウスにおける胸腺組織の遺伝子的変化および表現型上の変化(Genetic and Phenotypic Changes of Thymus Tissue in Mice during Pregnancy) Journal of Oral Health and Biosciences. 2017.06; 30 (1): 26-32. ( ichushi )
Ushio A, Arakaki R, Eguchi H, Hotta F, Yamada A, Kudo Y, Ishimaru N: Pathological Analysis of Ocular Lesions in a Murine Model of Sjögren's Syndrome. International journal of molecular sciences. 2017.06; 18 (6): ( PubMed , DOI )
Izawa T, author, Corresponding author, Arakaki R, Ishimaru N: Crosstalk between cytokine RANKL and AhR signalling in osteoclasts controls bone homeostasis Journal of Cytokine Biology. 2017.05; 2 (2): 114. ( DOI )
Dual role of Fas/FasL-mediated signal in peripheral immune tolerance 2017.04; 8 403. ( PubMed , DOI )
Shikama Y, Kudo Y, Ishimaru N, Funaki M: Potential Role of Free Fatty Acids in the Pathogenesis of Periodontitis and Primary Sjögren's Syndrome. International journal of molecular sciences. 2017.04; 18 (4): ( PubMed , DOI )
牛尾綾, LENNIKOV Mami, 大塚邦紘, 常松貴明, 石丸直澄, 高濱洋介: The layer protection of heterogeneous medullary thymic epithelial cells for autoimmune disease 日本病理学会会誌. 2023; 112 (1): 243. ( ichushi )
常松貴明, 俵宏彰, 佐藤真美, 永尾瑠佳, 福田一稀, 大塚邦紘, 牛尾綾, 石丸直澄: The acquired novel role of cancer cells induced by DNA damage signaling and its molecular mechanism 日本病理学会会誌. 2023; 112 (1): 277. ( ichushi )
俵宏彰, 常松貴明, 福田一稀, 永尾瑠佳, 佐藤真美, 大塚邦紘, 牛尾綾, 石丸直澄: Borealin-Survivin axis in components of CPC, regulate cancer metabolism in HNSCC 日本病理学会会誌. 2023; 112 (1): 264. ( ichushi )
大塚邦紘, 大塚邦紘, 大塚邦紘, 近藤博之, 九十九伸一, 九十九伸一, 新垣理恵子, 永尾瑠佳, 佐藤真美, 牛尾綾, 石丸直澄, 安友康二, 安友康二: CD153-CD30 axis contributes to the autoimmune pathology in salivary glands of Sjogren's syndrome 日本病理学会会誌. 2023; 112 (1): 242-243. ( ichushi )
永尾瑠佳, 大塚邦紘, 山本安希子, 牛尾綾, 佐藤真美, 俵宏彰, 田中秀卓, 常松貴明, 石丸直澄: Analysis of the role of co-inhibitory receptors on T cells to the pathogenesis of Sjogren's syndrome 日本病理学会会誌. 2023; 112 (1): 293. ( ichushi )
常松貴明, 俵宏彰, 大塚邦紘, 牛尾綾, 石丸直澄: The role of deubiquitinating enzymes in human papillomavirus-positive cancers 口腔組織培養学会誌. 2022; 31 (2): 19-26. ( ichushi )
佐藤真美, 牛尾綾, 福田一稀, 大塚邦紘, 常松貴明, 新垣理恵子, 石丸直澄: Involvement of CCL6 in the pathogenesis of pulmonary lesion in a mouse model for Sjogren's syndrome 日本病理学会会誌. 2022; 111 (1): 276. ( ichushi )
佐藤真美, 牛尾綾, 新垣理恵子, 俵宏彰, 常松貴明, 石丸直澄: Analysis of lung lesions in Sjogren's syndrome model mice 日本病理学会会誌. 2021; 110 (1): 277. ( ichushi )
A role of follicular helper T cell in the pathogenesis of Sjogren's syndrome 2020.03; 73 (3): 241-248. ( ichushi )
佐藤真美, 新垣理恵子, 牛尾綾, 常松貴明, 工藤保誠, 石丸直澄: The role of IL-33 in target organs of Sjogren's syndrome 日本病理学会会誌. 2020; 109 (1): 408. ( ichushi )
新垣理恵子, 佐藤真美, 木曽田暁, SHAO Wenhua, 牛尾綾, 常松貴明, 工藤保誠, 石丸直澄: Effect of inhalation exposure to carbon nanotubes and titanium dioxide on alveolar macrophages 日本病理学会会誌. 2020; 109 (1): 308. ( ichushi )
牛尾 綾, 新垣 理恵子, 工藤 保誠, 石丸 直澄: 次世代歯学研究者のゆくえ 自己免疫疾患モデルにおける標的臓器常在型マクロファージの役割 Journal of Oral Biosciences Supplement. 2019.10; 2019 61. ( ichushi )
青田 桂子, 山ノ井 朋子, 可児 耕一, 石丸 直澄, 東 雅之: シェーグレン症候群の病態形成におけるCXCL10-CXCR3の役割 日本口腔科学会雑誌. 2019.07; 68 (2): 175-176. ( ichushi )
大塚 邦紘, 山田 安希子, 齋藤 雅子, 牛尾 綾, 常松 貴明, 木曽田 暁, 工藤 保誠, 新垣 理恵子, 石丸 直澄: Ascl2を介した濾胞ヘルパーT細胞分化異常による自己免疫疾患の病態形成を促進する 日本病理学会会誌. 2019.04; 108 (1): 317. ( ichushi )
新垣 理恵子, 牛尾 綾, 大塚 邦紘, 工藤 保誠, 石丸 直澄: 多層化カーボンナノチューブ吸入暴露初期の肺胞マクロファージの動態 日本病理学会会誌. 2019.04; 108 (1): 353. ( ichushi )
榊原 健人, 中川 貴之, 福田 直志, 栗尾 奈愛, 玉谷 哲也, 真野 隆充, 大塚 邦紘, 工藤 保誠, 石丸 直澄, 宮本 洋二: 下顎骨に発生した腺性歯原性嚢胞の1例 日本口腔科学会雑誌. 2019.03; 68 (1): 50. ( ichushi )
榊原 健人, 中川 貴之, 福田 直志, 栗尾 奈愛, 玉谷 哲也, 真野 隆充, 大塚 邦紘, 工藤 保誠, 石丸 直澄, 宮本 洋二: 下顎骨に発生した腺性歯原性嚢胞の1例 日本口腔科学会雑誌. 2019.03; 68 (1): 50. ( ichushi )
大塚邦紘, 山田安希子, 齋藤雅子, 牛尾綾, 木曽田暁, 常松貴明, 工藤保誠, 新垣理恵子, 石丸直澄: シェーグレン症候群疾患モデルの自己免疫病変における濾胞ヘルパーT細胞の役割 Journal of Oral Biosciences Supplement (Web). 2018.09; 2018 ROMBUNNO.P1‐106 (WEB ONLY)-326. ( ichushi )
牛尾綾, 大塚邦紘, 新垣理恵子, 工藤保誠, 石丸直澄: 口腔疾患のサイエンス【シェーグレン症候群研究の最前線】 月刊細胞. 2018.09; 50 (10): 528‐531-531. ( ichushi )
石丸 直澄: 口腔外科領域における感染症の病理 日本口腔外科学会雑誌. 2018.07; 64 (7): 390-393. ( ichushi )
新垣 理恵子, 牛尾 綾, 大塚 邦紘, 工藤 保誠, 石丸 直澄: 全身吸入曝露による多層化カーボンナノチューブの肺胞マクロファージへの影響 日本病理学会会誌. 2018.04; 107 (1): 413. ( ichushi )
石丸 直澄: 免疫病理学の新展開 シェーグレン症候群における自己反応性獲得機序の解明 日本病理学会会誌. 2018.04; 107 (1): 207. ( ichushi )
西條 早紀, 常松 貴明, 大塚 邦紘, 牛尾 綾, 山田 安希子, 新垣 理恵子, 工藤 保誠, 石丸 直澄: Emi1の過剰発現による人工口腔癌幹細胞の作成 日本病理学会会誌. 2018.04; 107 (1): 516-517. ( ichushi )
沼田 雪乃, 大塚 邦紘, 山田 安希子, 牛尾 綾, 常松 貴明, 工藤 保誠, 新垣 理恵子, 石丸 直澄: シェーグレン症候群疾患モデルにおけるNotchシグナルの役割 日本病理学会会誌. 2018.04; 107 (1): 522. ( ichushi )
中山 慎一朗, 新垣 理恵子, 牛尾 綾, 大塚 邦紘, 常松 貴明, 工藤 保誠, 石丸 直澄: シェーグレン症候群モデルマウス唾液腺におけるIL-33の発現とその役割 日本病理学会会誌. 2018.04; 107 (1): 519. ( ichushi )
中山 慎一朗, 新垣 理恵子, 牛尾 綾, 大塚 邦紘, 常松 貴明, 工藤 保誠, 石丸 直澄: シェーグレン症候群モデルマウス唾液腺におけるIL-33の発現とその役割 日本病理学会会誌. 2018.04; 107 (1): 519. ( ichushi )
梅田 将旭, 常松 貴明, 大塚 邦紘, 牛尾 綾, 山田 安希子, 新垣 理恵子, 工藤 保誠, 石丸 直澄: 口腔癌におけるPeriostinスプライシングバリアントの同定とその役割 日本病理学会会誌. 2018.04; 107 (1): 518. ( ichushi )
梅田 将旭, 常松 貴明, 大塚 邦紘, 牛尾 綾, 山田 安希子, 新垣 理恵子, 工藤 保誠, 石丸 直澄: 口腔癌におけるPeriostinスプライシングバリアントの同定とその役割 日本病理学会会誌. 2018.04; 107 (1): 518. ( ichushi )
牛尾 綾, 新垣 理恵子, 大塚 邦紘, 山田 安希子, 工藤 保誠, 石丸 直澄: CCL22産生唾液腺マクロファージはシェーグレン症候群の病態形成に関与する 日本病理学会会誌. 2018.04; 107 (1): 303. ( ichushi )
常松 貴明, 工藤 保誠, 新垣 理恵子, 大塚 邦紘, 牛尾 綾, 山田 安希子, 小川 博久, 常山 幸一, 石丸 直澄: DNAライセンシング因子CDT1の新規ユビキチン分解制御機構とその意義の解明 日本病理学会会誌. 2018.04; 107 (1): 340. ( ichushi )
大塚邦紘, 山田安希子, 齋藤雅子, 牛尾綾, 木曽田暁, 常松貴明, 新垣理恵子, 工藤保誠, 石丸直澄: シェーグレン症候群疾患モデルの自己免疫病変における濾胞ヘルパーT細胞の役割 日本シェーグレン症候群学会学術集会プログラム・抄録集. 2018; 27th 80-326. ( ichushi )
牛尾綾, 新垣理恵子, 大塚邦紘, 山田安希子, 工藤保誠, 石丸直澄: CCL22産生唾液腺マクロファージはシェーグレン症候群の病態に関与する 日本シェーグレン症候群学会学術集会プログラム・抄録集. 2018; 27th 85.
常松 貴明, 山田 安希子, 新垣 理恵子, 石丸 直澄, 工藤 保誠: タンパク質のユビキチン分解を介した細胞周期と分化の制御機構 生命科学系学会合同年次大会. 2017.12; 2017年度 [1P-0193]. ( ichushi )
四釜 洋介, 工藤 保誠, 石丸 直澄, 船木 真理: 飽和脂肪酸が歯周病の病態形成に関与する可能性 Journal of Oral Biosciences Supplement. 2017.09; 2017 56. ( ichushi )
石丸 直澄: 歯科基礎医学の臨床医歯学へ応用と展開 環境因子による自己反応性獲得機構の解明 自己免疫疾患の新たな病因論 Journal of Oral Biosciences Supplement. 2017.09; 2017 72. ( ichushi )
梅田 将旭, 常松 貴明, 山田 安希子, 新垣 理恵子, 工藤 保誠, 石丸 直澄: 口腔扁平上皮癌におけるPeriostinスプライシングバリアントの新たな役割 Journal of Oral Biosciences Supplement. 2017.09; 2017 392. ( ichushi )
常松 貴明, 工藤 保誠, 山田 安希子, 新垣 理恵子, 石丸 直澄: 多能性幹細胞におけるユビキチンプロテアソーム経路による未分化性維持機構 Journal of Oral Biosciences Supplement. 2017.09; 2017 372. ( ichushi )
青田 桂子, 山ノ井 朋子, 可児 耕一, 石丸 直澄, 東 雅之: シェーグレン症候群におけるCXCR3+マクロファージの動態 日本口腔科学会雑誌. 2017.07; 66 (2): 147-148. ( ichushi )
石丸 直澄: 【シェーグレン症候群の病因病態】 環境因子と免疫トレランスの破綻 臨床免疫・アレルギー科. 2017.04; 67 (4): 360-365. ( ichushi )
常松 貴明, 工藤 保誠, 山田 安希子, 新垣 理恵子, 小川 博久, 常山 幸一, 石丸 直澄: 胎児性癌細胞におけるユビキチンプロテアソーム経路による未分化性維持機構 日本病理学会会誌. 2017.03; 106 (1): 356. ( ichushi )
青田 桂子, 山ノ井 朋子, 可児 耕一, 石丸 直澄, 東 雅之: ヒト唾液腺細胞株におけるCXCL10の発現機能解析 口腔組織培養学会誌. 2017.03; 26 (1): 15-16. ( ichushi )
牛尾 綾, 新垣 理恵子, 山田 安希子, 大塚 邦紘, 鯨岡 聡子, 常松 貴明, 工藤 保誠, 石丸 直澄: シェーグレン症候群の唾液腺におけるマクロファージサブセットと病態への関与 日本病理学会会誌. 2017.03; 106 (1): 329. ( ichushi )
山田 安希子, 新垣 理恵子, 牛尾 綾, 大塚 邦紘, 黒澤 美愛, 工藤 保誠, 石丸 直澄: シェーグレン症候群における制御性T細胞の分化誘導メカニズムの解明 日本病理学会会誌. 2017.03; 106 (1): 473. ( ichushi )
大塚 邦紘, 山田 安希子, 齋藤 雅子, 牛尾 綾, 黒澤 実愛, 鯨岡 聡子, 常松 貴明, 工藤 保誠, 新垣 理恵子, 石丸 直澄: シェーグレン症候群モデルマウスにおける濾胞ヘルパーT細胞の解析 日本病理学会会誌. 2017.03; 106 (1): 324. ( ichushi )
鯨岡 聡子, 工藤 保誠, 常松 貴明, 牛尾 綾, 大塚 邦紘, 山田 安希子, 新垣 理恵子, 石丸 直澄: 歯原性明細胞癌細胞株の樹立とその性状解析 日本病理学会会誌. 2017.03; 106 (1): 349. ( ichushi )
梅田 将旭, 常松 貴明, 斎藤 雅子, 山田 安希子, 新垣 理恵子, 工藤 保誠, 石丸 直澄: 口腔癌におけるPeriostinスプライシングバリアントの新たな役割 日本病理学会会誌. 2017.03; 106 (1): 518. ( ichushi )
新垣 理恵子, 山田 耕一, 齋藤 雅子, 大塚 邦紘, 山本 安希子, 常松 貴明, 工藤 保誠, 菅野 純, 石丸 直澄: 多層化カーボンナノチューブ長期暴露による免疫システムへの影響 日本病理学会会誌. 2017.03; 106 (1): 415. ( ichushi )
大塚邦紘, 山田安希子, 齋藤雅子, 牛尾綾, 鯨岡聡子, 黒澤実愛, 常松貴明, 新垣理恵子, 工藤保誠, 石丸直澄: シェーグレン症候群疾患モデルにおける胚中心反応の解析 日本臨床口腔病理学会総会・学術大会プログラム・抄録集(Web). 2017; 28th 97 (WEB ONLY).
Keiko Aota, Koichi Kani, Shinji Ono, Kohei Naniwa, Yukihiro Momota, Makoto Fukui, Naozumi Ishimaru, Masayuki Azuma: Activation of Janus kinase 2 contributes to the autoimmune pathology in the salivary glands of patients with Sjögren's syndrome Oral Science International. 2024.04; ( DOI )
Daishiro Kobayashi, Masaya Deda, Junya Hayashi, Kota Hidaka, Yutaka Kohmura, Takaaki Tsunematsu, Kohei Nishino, Harunori Yoshikawa, Kento Ohkawachi, Kiyomi Nigorikawa, Tetsuro Yoshimaru, Naozumi Ishimaru, Wataru Nomura, Toyomasa Katagiri, Hidetaka Kosako, Akira Otaka: Sulfoxide-mediated Cys-Trp-selective bioconjugation that enables protein labeling and peptide heterodimerization 2024.01; ( DOI )
Naozumi Ishimaru, Kunihiro Otsuka, Takaaki Tsunematsu, Yuhji Taquahashi, Jun Kanno: Chronic Immunotoxicity of Multi-Walled Carbon Nanotubes on Macrophages via MMP-12 Annals of Work Exposures and Health. 2023.05; 67 (Supplement_1): i74. ( DOI )
俵宏彰, 常松貴明, 永尾瑠佳, 松澤鎮史, 大塚邦紘, 牛尾綾, 石丸直澄: Borealin-Survivin axis regulates cancer metabolism through chromosome passenger complex in head and neck squamous cell carcinoma 日本臨床口腔病理学会総会・学術大会プログラム・抄録集(Web). 2023; 34th
永尾瑠佳, 山本安希子, 大塚邦紘, 牛尾綾, 俵宏彰, 松澤鎮史, 田村海, 川人祐樹, 常松貴明, 石丸直澄: Analysis of the role of Trat1 in the pathogenesis of Sjoegren's syndrome 日本臨床口腔病理学会総会・学術大会プログラム・抄録集(Web). 2023; 34th
常松貴明, 俵宏彰, 佐藤真実, 新垣理恵子, 大塚邦紘, 牛尾綾, 石丸直澄: The novel function of Borealin, which is a component of chromosome passenger complex, in head and neck squamous cell carcinoma Journal of Oral Biosciences Supplement (Web). 2022; 2022
Yuri Yoshikawa, Takashi Izawa, Yusaku Hamada, Hiroko Takenaga, Ziyi Wang, Naozumi Ishimaru, Hiroshi Kamioka: Roles for B[a]P and FICZ in subchondral bone metabolism and experimental temporomandibular joint osteoarthritis via the AhR/Cyp1a1 signaling axis Scientific Reports. 2021.12; 11 (1): ( DOI )
Mami Sato, Rieko Arakaki, Hiroaki Tawara, Takaaki Tsunematsu, Naozumi Ishimaru: Formation of Autoimmune Lesions Is Independent of Antibiotic Treatment in NOD Mice International Journal of Molecular Sciences. 2021.03; 22 (6): 3239. ( DOI )
ARAKAKI Rieko, TSUNEMATSU Takaaki, TAQUAHASHI Yuhji, KANNO Jun, ISHIMARU Naozumi: Pulmonary Immune Response and Molecular Mechanism of Fibrosis by Inhalation Exposure to Nanomaterials 日本免疫学会総会・学術集会記録(CD-ROM). 2021; 50
Naito KURIO, Kumiko KAMADA, Takumi KITAGAWA, Yasusei KUDO, Naozumi ISHIMARU, Yoji MIYAMOTO: A case of microcystic adnexal carcinoma arising in the upper gingiva Japanese Journal of Oral and Maxillofacial Surgery. 2020.09; 66 (9): 455-459. ( DOI )
Takaaki Tsunematsu, Rieko Arakaki, Hidehiko Kawai, Jan Ruppert, Koichi Tsuneyama, Naozumi Ishimaru, William C. Earnshaw, Michele Pagano, Yasusei Kudo: APC/CCdh1 is required for the termination of chromosomal passenger complex activity upon mitotic exit Journal of Cell Science. 2020.09; 133 (18): jcs251314. ( DOI )
Shinya Sento, Yasusei Kudo, Kenji Hibiya, Naozumi Ishimaru, Eri Sasabe, Naoya Kitamura, Tetsuya Yamamoto: Hyalinizing clear cell carcinoma of the anterior lingual salivary gland: A case report and review of the literature Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2020.07; 32 (4): 267-274. ( DOI )
大塚邦紘, 山田安希子, 齋藤雅子, 牛尾綾, 常松貴明, 工藤保誠, 新垣理恵子, 石丸直澄: A crucial role of follicular helper T cells in autoimmunity of a mouse model for Sjoegren's syndrome 日本臨床口腔病理学会総会・学術大会プログラム・抄録集(Web). 2018; 29th
Saito M, Otsuka K, Ushio A, Yamada A, Arakaki R, Kudo Y, Ishimaru N: Unique Phenotypes and Functions of Follicular Helper T Cell and Regulatory T Cell in Sjögren's Syndrome. Current rheumatology reviews. 2017.01; ( PubMed )
Ishimaru N: [Oral immune system and oral immune disorder.] Clinical calcium. 2017; 27 (10): 1363-1368. ( PubMed )