ヘルスインテリジェンス部門

54  件  
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  1. Shunsuke Kasai, Akio Shiomi, Hideyuki Shimizu, Monami Aoba, Yusuke Kinugasa, Takuya Miura, Kay Uehara, Jun Watanabe, Kazushige Kawai, Yoichi Ajioka: Risk factors and development of machine learning diagnostic models for lateral lymph node metastasis in rectal cancer: multicentre study. BJS Open. 2024.07; 8 (4): ( PubMed , DOI )

  2. Yoriyuki Konno, Keiya Uriu, Takayuki Chikata, Toru Takada, Jun-Ichi Kurita, Mahoko Takahashi Ueda, Saiful Islam, Benjy Jek Yang Tan, Jumpei Ito, Hirofumi Aso, Ryuichi Kumata, Carolyn Williamson, Shingo Iwami, Masafumi Takiguchi, Yoshifumi Nishimura, Eiji Morita, Yorifumi Satou, So Nakagawa, Yoshio Koyanagi, Kei Sato: Two-step evolution of HIV-1 budding system leading to pandemic in the human population. Cell Reports. 2024.02; 43 (2): 113697. ( PubMed , DOI )

  1. DNA hypomethylation characterizes genes encoding tissue-dominant functional proteins in liver and skeletal muscle 2023.11; 13 (1): ( DOI )

  2. Hirofumi Aso, Jumpei Ito, Haruka Ozaki, Yukie Kashima, Yutaka Suzuki, Yoshio Koyanagi, Kei Sato: Single-cell transcriptome analysis illuminating the characteristics of species-specific innate immune responses against viral infections. GigaScience. 2023.10; 12 giad086. ( PubMed , DOI )

  3. Funasaki S, Hatano A, Nakatsumi H, Koga D, Sugahara O, Yumimoto K, Baba M, Matsumoto M, Nakayama KI: A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection. iScience. 2023.09; 26 (9): 107552. ( PubMed , DOI )

  4. Kodama M, Toyokawa G, (20名省略), Bamba T, Shimizu H, Yoshizumi T, Nakayama KI: Modulation of host glutamine anabolism enhances the sensitivity of small cell lung cancer to chemotherapy Cell Reports. 2023.08; 42 (8): 112899.

  5. Oka, T; Higa, T; Sugahara, O; Koga, D; Nakayama, S; Nakayama, KI: Ablation of p57+ Quiescent Cancer Stem Cells Suppresses Recurrence after Chemotherapy of Intestinal Tumors CANCER RESEARCH. 2023.05; 83 (9): 1393-1409. ( PubMed , DOI )

  6. Fujinuma S, Nakatsumi H, Shimizu H, Sugiyama S, Harada A, Goya T, Tanaka M, Kohjima M, Takahashi M, Izumi Y, Yagi M, Kang D, Kaneko M, Shigeta M, Bamba T, Ohkawa Y, Nakayama KI: FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation Cell Reports. 2023.05; 42 (5): 112530. ( DOI )

  7. Hozumi H, Shimizu H: Bayesian network enables interpretable and state-of-the-art prediction of immunotherapy responses in cancer patients PNAS Nexus. 2023.04; 2 (5): pgad133. ( PubMed , DOI )

  1. Shimizu H, Kodama M, Matsumoto M, Orba Y, Sasaki Y, Sato A, Sawa H, Nakayama KI: LIGHTHOUSE illuminates therapeutics for a variety of diseases including COVID-19 iScience. 2022.10; 25 (11): 105314. ( PubMed , DOI )

  2. Toshiya Kokaji, Miki Eto, Atsushi Hatano, Katsuyuki Yugi, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-Ichi Hironaka, Yuki Ito, Riku Egami, Saori Uematsu, Akira Terakawa, Yifei Pan, Hideki Maehara, Dongzi Li, Yunfan Bai, Takaho Tsuchiya, Haruka Ozaki, Hiroshi Inoue, Hiroyuki Kubota, Yutaka Suzuki, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda: In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states. Sci Rep. 2022.08; 12 (1): 13719. ( PubMed , DOI )

  3. Akira Terakawa, Yanhui Hu, Toshiya Kokaji, Katsuyuki Yugi, Keigo Morita, Satoshi Ohno, Yifei Pan, Yunfan Bai, Andrey A Parkhitko, Xiaochun Ni, John M Asara, Martha L Bulyk, Norbert Perrimon, Shinya Kuroda: Trans-omics analysis of insulin action reveals a cell growth subnetwork which co-regulates anabolic processes. iScience. 2022.05; 25 (5): 104231. ( PubMed , DOI )

  4. Habara M, Sato Y, Goshima T, Sakurai M, Imai H, Shimizu H, Katayama Y, Hanaki S, Masaki T, Morimoto M, Nishikawa S, Toyama T, Shimada M: FKBP52 and FKBP51 Differentially Regulate the Stability of Estrogen Receptor in Breast Cancer Proc Natl Acad Sci U S A. 2022.04; 119 (15): e2110256119. ( PubMed , DOI )

  5. Satoshi Ohno, Saori Uematsu, Shinya Kuroda: Quantitative metabolic fluxes regulated by trans-omic networks. Biochem J. 2022.03; 479 (6): 787-804. ( PubMed , DOI )

  6. Higa T, Okita Y, Matsumoto A, Nakayama S, Oka T, Sugahara O, Koga D, Takeishi S, Nakatsumi H, Hosen N, Robine S, Taketo MM, Sato T, Nakayama KI: Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium. Nature communications. 2022.03; 13 (1): 1500. ( PubMed , DOI )

  7. Kakiuchi, T; Eguchi, K; Koga, D; Eguchi, H; Nishi, M; Sonoda, M; Ishimura, M; Matsuo, M: Changes in bone marrow and peripheral blood lymphocyte subset findings with onset of hepatitis-associated aplastic anemia MEDICINE. 2022.02; 101 (8): e28953. ( PubMed , DOI )

  8. Saori Uematsu, Satoshi Ohno, Kaori Y Tanaka, Atsushi Hatano, Toshiya Kokaji, Yuki Ito, Hiroyuki Kubota, Ken-Ichi Hironaka, Yutaka Suzuki, Masaki Matsumoto, Keiichi I Nakayama, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda: Multi-omics-based label-free metabolic flux inference reveals obesity-associated dysregulatory mechanisms in liver glucose metabolism. iScience. 2022.02; 25 (2): 103787. ( PubMed , DOI )

  9. Mise S, Matsumoto A, Shimada K, Hosaka T, Takahashi M, Ichihara K, Shimizu H, Shiraishi C, Saito D, Suyama M, Yasuda T, Ide T, Izumi Y, Bamba T, Kimura-Someya T, Shirouzu M, Miyata H, Ikawa M, Nakayama KI: Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis. Nature communications. 2022.02; 13 (1): 1071. ( PubMed , DOI )

  1. Ichihara K, Matsumoto A, Nishida H, Kito Y, Shimizu H, Shichino Y, Iwasaki S, Imami K, Ishihama Y, Nakayama KI: Combinatorial analysis of translation dynamics reveals eIF2 dependence of translation initiation at near-cognate codons Nucleic Acids Research. 2021.07; 49 (13): 7298-7317. ( PubMed , DOI )

  2. Kosugi Y, Uriu K, Suzuki N, Yamamoto K, Nagaoka S, Kimura I, Konno Y, Aso H, Willett BJ, Kobayashi T, Koyanagi Y, Ueda MT, Ito J, Sato K: Comprehensive Investigation on the Interplay between Feline APOBEC3Z3 Proteins and Feline Immunodeficiency Virus Vif Proteins. Journal of virology. 2021.06; 95 (13): e0017821. ( PubMed , DOI )

  3. Riku Egami, Toshiya Kokaji, Atsushi Hatano, Katsuyuki Yugi, Miki Eto, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-Ichi Hironaka, Saori Uematsu, Akira Terakawa, Yunfan Bai, Yifei Pan, Takaho Tsuchiya, Haruka Ozaki, Hiroshi Inoue, Shinsuke Uda, Hiroyuki Kubota, Yutaka Suzuki, Masaki Matsumoto, Keiichi I Nakayama, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda: Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle. iScience. 2021.03; 24 (3): 102217. ( PubMed , DOI )

  4. Shimizu H, Nakayama KI: A universal molecular prognostic score for gastrointestinal tumors. NPJ genomic medicine. 2021.02; 6 (1): 6. ( PubMed , DOI )

  1. Toshiya Kokaji, Atsushi Hatano, Yuki Ito, Katsuyuki Yugi, Miki Eto, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-Ichi Hironaka, Riku Egami, Akira Terakawa, Takaho Tsuchiya, Haruka Ozaki, Hiroshi Inoue, Shinsuke Uda, Hiroyuki Kubota, Yutaka Suzuki, Kazutaka Ikeda, Makoto Arita, Masaki Matsumoto, Keiichi I Nakayama, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda: Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity. Sci Signal. 2020.12; 13 (660): ( PubMed , DOI )

  2. Onoyama I, Nakayama S, Shimizu H, Nakayama KI: Loss of Fbxw7 Impairs Development of and Induces Heterogeneous Tumor Formation in the Mouse Mammary Gland. Cancer research. 2020.12; 80 (24): 5515-5530. ( PubMed , DOI )

  3. Young Sun Hwang, Shinnosuke Suzuki, Yasunari Seita, Jumpei Ito, Yuka Sakata, Hirofumi Aso, Kei Sato, Brian P Hermann, Kotaro Sasaki: Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells Nature Communications. 2020.11; 11 (1): 5656. ( PubMed , DOI )

  4. Satoshi Ohno, Lake-Ee Quek, James R Krycer, Katsuyuki Yugi, Akiyoshi Hirayama, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Tomoyoshi Soga, David E James, Shinya Kuroda: Kinetic Trans-omic Analysis Reveals Key Regulatory Mechanisms for Insulin-Regulated Glucose Metabolism in Adipocytes. iScience. 2020.09; 23 (9): 101479. ( PubMed , DOI )

  5. Nakano Y, Yamamoto K, Ueda MT, Soper A, Konno Y, Kimura I, Uriu K, Kumata R, Aso H, Misawa N, Nagaoka S, Shimizu S, Mitsumune K, Kosugi Y, Juarez-Fernandez G, Ito J, Nakagawa S, Ikeda T, Koyanagi Y, Harris RS, Sato K: A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans. PLoS pathogens. 2020.09; 16 (9): e1008812. ( PubMed , DOI )

  6. Hirofumi Aso, Shumpei Nagaoka, Eiryo Kawakami, Jumpei Ito, Saiful Islam, Benjy Jek Yang Tan, Shinji Nakaoka, Koichi Ashizaki, Katsuyuki Shiroguchi, Yutaka Suzuki, Yorifumi Satou, Yoshio Koyanagi, Kei Sato: Multiomics investigation revealing the characteristics of HIV-1-infected cells in vivo Cell Reports. 2020.07; 32 (2): 107887. ( PubMed , DOI )

  7. Yamauchi Y, Nita A, Nishiyama M, Muto Y, Shimizu H, Nakatsumi H, Nakayama KI.: Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development Genes Cells. 2020.06; 25 (6): 427-438. ( PubMed , DOI )

  8. Shimizu H, Nakayama KI: Artificial intelligence in oncology. Cancer science. 2020.05; 111 (5): 1452-1460. ( PubMed , DOI )

  9. Oshikawa K, Matsumoto M, Kodama M, Shimizu H, Nakayama KI: A fail-safe system to prevent oncogenesis by senescence is targeted by SV40 small T antigen. Oncogene. 2020.03; 39 (10): 2170-2186. ( PubMed , DOI )

  10. Kodama M, Oshikawa K, Shimizu H, Yoshioka S, Takahashi M, Izumi Y, Bamba T, Tateishi C, Tomonaga T, Matsumoto M, Nakayama KI: A shift in glutamine nitrogen metabolism contributes to malignant progression of cancer Nature Communications. 2020.03; 11 (1320):

  11. Lake-Ee Quek, James R Krycer, Satoshi Ohno, Katsuyuki Yugi, Daniel J Fazakerley, Richard Scalzo, Sarah D Elkington, Ziwei Dai, Akiyoshi Hirayama, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Jason W Locasale, Tomoyoshi Soga, David E James, Shinya Kuroda: Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin. iScience. 2020.02; 23 (2): 100855. ( PubMed , DOI )

  1. Shimizu H, Nakayama KI: A 23 gene-based molecular prognostic score precisely predicts overall survival of breast cancer patients. EBioMedicine. 2019.08; 46 150-159. ( PubMed , DOI )

  2. Rate-oriented trans-omics: integration of multiple omic data on the basis of reaction kinetics 2019.06; 15 109-120.

  3. Muto Y, Moroishi T, Ichihara K, Nishiyama M, Shimizu H, Eguchi H, Moriya K, Koike K, Mimori K, Mori M, Katayama Y, Nakayama KI: Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis Journal of Experimental Medicine. 2019.04; 216 (4): 950-965. ( PubMed , DOI )

  4. Hirofumi Aso, Jumpei Ito, Yoshio Koyanagi, Kei Sato: Comparative description of the expression profile of interferon-stimulated genes in multiple cell lineages targeted by HIV-1 infection Frontiers in Microbiology. 2019.03; 10 429. ( PubMed , DOI )

  5. Shimizu H, Takeishi S, Nakatsumi H, Nakayama KI: Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells. JCI insight. 2019.02; 4 (4): ( PubMed , DOI )

  6. Nakamura, T; Nishi, M; Rikitake, M; Koga, D; Eto, J; Tajima, D; Toda, S; Matsuo, M: A case of subacute combined degeneration of the spinal cord due to folic acid and copper deficiency BRAIN & DEVELOPMENT. 2019.01; 41 (1): 111-115. ( PubMed , DOI )

  1. Konno Y, Nagaoka S, Kimura I, Yamamoto K, Kagawa Y, Kumata R, Aso H, Ueda MT, Nakagawa S, Kobayashi T, Koyanagi Y, Sato K: New World feline APOBEC3 potently controls inter-genus lentiviral transmission. Retrovirology. 2018.04; 15 (1): 31. ( PubMed , DOI )

  2. Kei Sato, Naoko Misawa, Junko S Takeuchi, Tomoko Kobayashi, Taisuke Izumi, Hirofumi Aso, Shumpei Nagaoka, Keisuke Yamamoto, Izumi Kimura, Yoriyuki Konno, Yusuke Nakano, Yoshio Koyanagi: Experimental adaptive evolution of simian immunodeficiency virus SIVcpz to pandemic human immunodeficiency virus type 1 by using a humanized mouse model Journal of Virology. 2018.02; 92 (4): e01905-17. ( PubMed , DOI )

  1. James R Krycer, Katsuyuki Yugi, Akiyoshi Hirayama, Daniel J Fazakerley, Lake-Ee Quek, Richard Scalzo, Satoshi Ohno, Mark P Hodson, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Westa Domanova, Benjamin L Parker, Marin E Nelson, Sean J Humphrey, Nigel Turner, Kyle L Hoehn, Gregory J Cooney, Tomoyoshi Soga, Shinya Kuroda, David E James: Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism. Cell Rep. 2017.12; 21 (12): 3536-3547. ( PubMed , DOI )

  2. Yusuke Nakano, Hirofumi Aso, Andrew Soper, Eri Yamada, Miyu Moriwaki, Guillermo Juarez-Fernandez, Yoshio Koyanagi, Kei Sato: A conflict of interest: the evolutionary arms race between mammalian APOBEC3 and lentiviral Vif Retrovirology. 2017.05; 14 (1): 31. ( PubMed , DOI )

  3. Andrew Soper, Guillermo Juarez-Fernandez, Hirofumi Aso, Miyu Moriwaki, Eri Yamada, Yusuke Nakano, Yoshio Koyanagi, Kei Sato: Various plus unique: Viral protein U as a plurifunctional protein for HIV-1 replication Experimental Biology and Medicine. 2017.04; 242 (8): 850-858. ( PubMed , DOI )

  1. Takanori Sano, Kentaro Kawata, Satoshi Ohno, Katsuyuki Yugi, Hiroaki Kakuda, Hiroyuki Kubota, Shinsuke Uda, Masashi Fujii, Katsuyuki Kunida, Daisuke Hoshino, Atsushi Hatano, Yuki Ito, Miharu Sato, Yutaka Suzuki, Shinya Kuroda: Selective control of up-regulated and down-regulated genes by temporal patterns and doses of insulin. Sci Signal. 2016.11; 9 (455): ra112. ( PubMed , DOI )

  1. Kento Tokuyama, Satoshi Ohno, Katsunori Yoshikawa, Takashi Hirasawa, Shotaro Tanaka, Chikara Furusawa, Hiroshi Shimizu: Increased 3-hydroxypropionic acid production from glycerol, by modification of central metabolism in Escherichia coli. Microbial Cell Factories. 2014.05; 13 64. ( PubMed , DOI )

  2. Satoshi Ohno, Hiroshi Shimizu, Chikara Furusawa: FastPros: screening of reaction knockout strategies for metabolic engineering. Bioinformatics. 2014.04; 30 (7): 981-987. ( PubMed , DOI )

  3. Nobutaka Nakashima, Satoshi Ohno, Katsunori Yoshikawa, Hiroshi Shimizu, Tomohiro Tamura: A vector library for silencing central carbon metabolism genes with antisense RNAs in Escherichia coli. Applied and Environmental Microbiology. 2014.01; 80 (2): 564-573. ( PubMed , DOI )

  1. Satoshi Ohno, Chikara Furusawa, Hiroshi Shimizu: In silico screening of triple reaction knockout Escherichia coli strains for overproduction of useful metabolites. J Biosci Bioeng. 2013.02; 115 (2): 221-228. ( PubMed , DOI )

  1. Yuriko Saiki, Yuki Yoshino, Hiroko Fujimura, Tatsuya Manabe, Yuki Kudo, Miki Shimada, Nariyasu Mano, Tomohiro Nakano, Yoonha Lee, Shinjiro Shimizu, Shinya Oba, Sho Fujiwara, Hideyuki Shimizu, Na Chen, Zhaleh Kashkouli Nezhad, Guo Jin, Shinichi Fukushige, Makoto Sunamura, Masaharu Ishida, Fuyuhiko Motoi, Shinichi Egawa, Michiaki Unno, Akira Horii: DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells Biochem Biophys Res Commun.. 2012.04; 421 (1): 98-104. ( PubMed , DOI )

  1. Shimizu H, Horii A, Sunamura M, Motoi F, Egawa S, Unno M, Fukushige S: Identification of epigenetically silenced genes in human pancreatic cancer by a novel method "microarray coupled with methyl-CpG targeted transcriptional activation" (MeTA-array) Biochem Biophys Res Commun.. 2011.07; 411 (1): 162-167. ( PubMed , DOI )

  1. 代謝フラックスの定量によるトランスオミクスネットワークの理解 2022;

  1. 大腸菌による有用物質生産に向けた 3 重反応破壊の in silico スクリーニング (2014 生物工学論文賞) 2015;

  1. Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity 2024.03; 27 (3): 109121. ( DOI )

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