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Dan Tomomasa, Claire Booth, Jack J Bleesing, Takeshi Isoda, Chie Kobayashi, Kazutoshi Koike, Takeshi Taketani, Akihisa Sawada, Akihiro Tamura, Rebecca A Marsh, Tomohiro Morio, Andrew R Gennery, Hirokazu Kanegane: Preemptive hematopoietic cell transplantation for asymptomatic patients with X-linked lymphoproliferative syndrome type 1 Clin Immunol. 2022.03; 237 108993. ( PubMed , DOI )

Yuki Ichimura, Risa Konishi, Miwako Shobo, Sae Inoue, Mari Okune, Akemi Maeda, Ryota Tanaka, Noriko Kubota, Isao Matsumoto, Akiko Ishii, Akira Tamaoka, Asami Shimbo, Masaaki Mori, Tomohiro Morio, Takayuki Kishi, Takako Miyamae, Jantima Tanboon, Michio Inoue, Ichizo Nishino, Manabu Fujimoto, Toshifumi Nomura, Naoko Okiyama: Anti-nuclear matrix protein 2 antibody-positive inflammatory myopathies represent extensive myositis without dermatomyositis-specific rash. Rheumatology (Oxford). 2022.03; 61 (3): 1222-1227. ( PubMed , DOI )

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Hiroki Matsuda, Yoichi Nibe-Shirakihara, Akiko Tamura, Emi Aonuma, Satoko Arakawa, Kana Otsubo, Yasuhiro Nemoto, Takashi Nagaishi, Kiichiro Tsuchiya, Shigeomi Shimizu, Averil Ma, Mamoru Watanabe, Motohiro Uo, Ryuichi Okamoto, Shigeru Oshima: Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice. Biochem Biophys Res Commun. 2022.02; 592 74-80. ( PubMed , DOI )

Dan Tomomasa, Kay Tanita, Seishi Higashi, Yuri Tasaka, Takashi Shimamura, Urara Sakurai, Tomoyo Matsubara, Satoshi Okada, Tomohiro Morio, Hirokazu Kanegane: Early diagnosis of partial interferon-γ receptor 1 deficiency prevents the development of Bacille de Calmette et Guérin osteomyelitis Clin Immunol. 2022.02; 235 108933. ( PubMed , DOI )

Teppei Ohkawa, Akira Nishimura, Kenjiro Kosaki, Yuki Aoki-Nogami, Daisuke Tomizawa, Kenichi Kashimada, Tomohiro Morio, Motohiro Kato, Shuki Mizutani, Masatoshi Takagi: PAX3/7-FOXO1 fusion-negative alveolar rhabdomyosarcoma in Schuurs-Hoeijmakers syndrome. J Hum Genet. 2022.01; 67 (1): 51-54. ( PubMed , DOI )

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Sho Hosaka, Takahiro Kido, Kazuo Imagawa, Hiroko Fukushima, Tomohiro Morio, Shigeaki Nonoyama, Hidetoshi Takada: Vaccination for Patients with Inborn Errors of Immunity: a Nationwide Survey in Japan J Clin Immunol. 2022.01; 43 (1): 183-194. ( PubMed , DOI )

Yusuke Noguchi, Tsunanori Shidei, Chikako Morioka, Kenichi Kashimada, Tomohiro Morio: A suspected case of heterotopic glia in an MM-twin discordant for anencephaly Pediatr Int. 2022.01; 64 (1): e15027. ( PubMed , DOI )

Etsushi Toyofuku, Kozue Takeshita, Hidenori Ohnishi, Yuko Kiridoshi, Hiroaki Masuoka, Tomonori Kadowaki, Ryuta Nishikomori, Kenichi Nishimura, Chie Kobayashi, Takasuke Ebato, Tomonari Shigemura, Yuzaburo Inoue, Wataru Suda, Masahira Hattori, Tomohiro Morio, Kenya Honda, Hirokazu Kanegane: Dysregulation of the Intestinal Microbiome in Patients With Haploinsufficiency of A20. Front Cell Infect Microbiol. 2022.01; 11 787667. ( PubMed , DOI )

Dan Tomomasa, Takeshi Sato, Tomonobu Hasegawa, Tomohiro Morio, Hirokazu Kanegane: Cartilage-hair hypoplasia with T-cell dysfunction. Pediatr Int. 2022.01; 64 (1): e15080. ( PubMed , DOI )

Akihiro Hoshino, Etsushi Toyofuku, Noriko Mitsuiki, Motoi Yamashita, Keisuke Okamoto, Michio Yamamoto, Kenji Kanda, Genki Yamato, Dai Keino, Yuri Yoshimoto-Suzuki, Junji Kamizono, Yasuhiro Onoe, Takuya Ichimura, Mika Nagao, Masaru Yoshimura, Koji Tsugawa, Toru Igarashi, Kanako Mitsui-Sekinaka, Yujin Sekinaka, Takehiko Doi, Takahiro Yasumi, Yozo Nakazawa, Masatoshi Takagi, Kohsuke Imai, Shigeaki Nonoyama, Tomohiro Morio, Sylvain Latour, Hirokazu Kanegane: Clinical Courses of IKAROS and CTLA4 Deficiencies: A Systematic Literature Review and Retrospective Longitudinal Study Front Immunol. 2022.01; 12 784901. ( PubMed , DOI )

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Maki Gau, Ryota Suga, Atsushi Hijikata, Ayako Kashimada, Masatoshi Takagi, Ryuichi Nakagawa, Kei Takasawa, Tsuyoshi Shirai, Kenichi Kashimada, Tomohiro Morio: A novel variant of NR5A1, p.R350W implicates potential interactions with unknown co-factors or ligands. Front Endocrinol (Lausanne). 2022; 13 1033074. ( PubMed , DOI )

Kensuke Miyake, Junya Ito, Hajime Karasuyama: Role of Basophils in a Broad Spectrum of Disorders. Front Immunol. 2022; 13 902494. ( PubMed , DOI )

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Tsubasa Okano, Akira Nishimura, Kento Inoue, Takuya Naruto, Shown Tokoro, Takahiro Tomoda, Takahiro Kamiya, Asami Simbo, Yuko Akutsu, Keisuke Okamoto, Tzuwen Yeh, Takeshi Isoda, Masakatsu Yanagimachi, Michiko Kajiwara, Kohsuke Imai, Hirokazu Kanegane, Masaaki Mori, Tomohiro Morio, Masatoshi Takagi: Somatic mutation in RUNX1 underlies mucocutaneus inflammatory manifestations. Rheumatology (Oxford). 2021.12; 60 (12): e429-e431. ( PubMed , DOI )

Hye Sun Kuehn, Jingjie Chang, Motoi Yamashita, Julie E Niemela, Chengcheng Zou, Kazuki Okuyama, Junji Harada, Jennifer L Stoddard, Cristiane J Nunes-Santos, Brigette Boast, Ryan M Baxter, Elena W Y Hsieh, Mary Garofalo, Thomas A Fleisher, Tomohiro Morio, Ichiro Taniuchi, Cullen M Dutmer, Sergio D Rosenzweig: T and B cell abnormalities, pneumocystis pneumonia, and chronic lymphocytic leukemia associated with an AIOLOS defect in patients. J Exp Med. 2021.12; 218 (12): ( PubMed , DOI )

Karasuyama Hajime, Shibata Sho, Yoshikawa Soichiro, Miyake Kensuke: 免疫系において軽視されてきた非主流派の好塩基球はついに脚光を浴びる場所にやってきた(Basophils, a neglected minority in the immune system, have come into the limelight at last) International Immunology. 2021.12; 33 (12): 809-813. ( 医中誌 )

Tomomasa D, Isoda T, Mitsuiki N, Yamashita M, Morishita A, Tomoda T, Okano T, Endo A, Kamiya T, Yanagimachi M, Imai K, Kanegane H, Takagi M, Morio T : Successful ruxolitinib administration for a patient with steroid-refractory idiopathic pneumonia syndrome following hematopoietic stem cell transplantation: A case report and literature review. Clin Case Rep. 2021.12; 9 (12): e05242. ( PubMed , DOI )

Ishii T, Nawa N, Morio T, Fujiwara T: Association between nationwide introduction of public-access defibrillation and sudden cardiac death in Japan: An interrupted time-series analysis. International journal of cardiology. 2021.12; ( PubMed , DOI )

Saori Noguchi, Shigeomi Shimizu: Molecular mechanisms and biological roles of GOMED FEBS Journal. 2021.11; ( DOI )

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Miwako Toyohara, Yuko Kajiho, Etsushi Toyofuku, Chie Takahashi, Keiho Owada, Shoichiro Kanda, Yutaka Harita, Hidenori Ohnishi, Taizo Wada, Kohsuke Imai, Hirokazu Kanegane, Tomohiro Morio, Akira Oka: An infant with X-linked anhidrotic ectodermal dysplasia with immunodeficiency presenting with Pneumocystis pneumonia: A case report Clin Case Rep. 2021.11; 9 (11): e05093. ( PubMed , DOI )

Yukako Oda, Chisato Takahashi, Shota Harada, Shun Nakamura, Daxiao Sun, Kazumi Kiso, Yuko Urata, Hitoshi Miyachi, Yoshinori Fujiyoshi, Alf Honigmann, Seiichi Uchida, Yasushi Ishihama, Fumiko Toyoshima: Discovery of anti-inflammatory physiological peptides that promote tissue repair by reinforcing epithelial barrier formation. Sci Adv. 2021.11; 7 (47): eabj6895. ( PubMed , DOI )

Kei Takasawa, Hirokazu Kanegane, Kenichi Kashimada, Tomohiro Morio: Endocrinopathies in Inborn Errors of Immunity Front Immunol. 2021.11; 12 786241. ( PubMed , DOI )

Mitsuru Mizuno, Kentaro Endo, Hisako Katano, Naoki Amano, Masaki Nomura, Yoshinori Hasegawa, Nobutake Ozeki, Hideyuki Koga, Naoko Takasu, Osamu Ohara, Tomohiro Morio, Ichiro Sekiya: Transplantation of human autologous synovial mesenchymal stem cells with trisomy 7 into the knee joint and 5 years of follow-up. Stem Cells Transl Med. 2021.11; 10 (11): 1530-1543. ( PubMed , DOI )

Satoshi Miyamoto, Katsutsugu Umeda, Mio Kurata, Akira Nishimura, Masakatsu Yanagimachi, Masataka Ishimura, Maho Sato, Tomonari Shigemura, Motohiro Kato, Yoji Sasahara, Akihiro Iguchi, Takashi Koike, Yoshiyuki Takahashi, Michiko Kajiwara, Masami Inoue, Yoshiko Hashii, Hiromasa Yabe, Koji Kato, Yoshiko Atsuta, Kohsuke Imai, Tomohiro Morio: Hematopoietic Cell Transplantation for Severe Combined Immunodeficiency Patients: a Japanese Retrospective Study. J Clin Immunol. 2021.11; 41 (8): 1865-1877. ( PubMed , DOI )

Yuko Ishii, Aiko Sato-Otsubo, Junko Takita, Tomohiro Morio, Masatoshi Takagi: Copy number alteration analysis for neuroblastoma using droplet digital polymerase chain reaction. Pediatr Int. 2021.10; 63 (10): 1192-1197. ( PubMed , DOI )

Yoko Saito, Kei Takasawa, Maki Gau, Takeru Yamauchi, Ryuichi Nakagawa, Yuichi Miyakawa, Akito Sutani, Atsumi Hosokawa-Tsuji, Shigeru Takishima, Yohei Matsubara, Tomohiro Morio, Kenichi Kashimada: Adrenal suppression and anthropometric data at two years of age was not influenced by the initial hydrocortisone dose in patients with 21-hydroxylase deficiency. Clin Pediatr Endocrinol. 2021.10; 30 (4): 155-161. ( PubMed , DOI )

Motoi Yamashita, Tomohiro Morio: Another Exciting Data-HCT Successfully Cured Patients with DADA2 : A commentary on "Hematopoietic cell transplantation cures adenosine deaminase 2 deficiency: report on 30 patients" by Hashem H et al. J Clin Immunol. 2021.10; 41 (7): 1443-1445. ( PubMed , DOI )

Keisuke Okamoto, Tomohiro Morio: Inborn errors of immunity with eosinophilia. Allergol Int. 2021.10; 70 (4): 415-420. ( PubMed , DOI )

Koji Kato, Hiromasa Yabe, Nobuyuki Shimozawa, Souichi Adachi, Mineo Kurokawa, Yoshiko Hashii, Atsushi Sato, Nao Yoshida, Makiko Kaga, Osamu Onodera, Shunichi Kato, Yoshiko Atsuta, Tomohiro Morio: Stem cell transplantation for pediatric patients with adrenoleukodystrophy: A nationwide retrospective analysis in Japan. Pediatr Transplant. 2021.10; e14125. ( PubMed , DOI )

Shintaro Ono, Kozue Takeshita, Yuko Kiridoshi, Motohiro Kato, Takahiro Kamiya, Akihiro Hoshino, Masakatsu Yanagimachi, Katsuhiro Arai, Ichiro Takeuchi, Nariaki Toita, Toshihiko Imamura, Yoji Sasahara, Junichi Sugita, Kazuko Hamamoto, Masanobu Takeuchi, Shoji Saito, Masaei Onuma, Hiroshi Tsujimoto, Masahiro Yasui, Takashi Taga, Yuki Arakawa, Yuichi Mitani, Nobuyuki Yamamoto, Kohsuke Imai, Wataru Suda, Masahira Hattori, Osamu Ohara, Tomohiro Morio, Kenya Honda, Hirokazu Kanegane: Hematopoietic cell transplantation rescues inflammatory bowel disease and dysbiosis of gut microbiota in XIAP deficiency. J Allergy Clin Immunol Pract. 2021.10; 9 (10): 3767-3780. ( PubMed , DOI )

Kasai S, Li X, Torii S, Yasumoto KI, Sogawa K: Direct protein-protein interaction between Npas4 and IPAS mutually inhibits their critical roles in neuronal cell survival and death. Cell death discovery. 2021.10; 7 (1): 300. ( PubMed , DOI )

Takuto Tokuhiro, Akane Ishikawa, Haruka Sato, Shunya Takita, Ayuri Yoshikawa, Ryoko Anzai, Shinichi Sato, Ryohei Aoyagi, Makoto Arita, Yasuaki Aratani, Shigeomi Shimizu, Masato Tanaka, Satoshi Yotsumoto: Oxidized phospholipids and neutrophil elastase coordinately play critical roles in NET formation Frontiers in Cell and Developmental Biology. 2021.09; ( DOI )

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Toshihisa Nagao, Yoshinori Yamanishi, Kensuke Miyake, Mio Teranishi, Saori Takahashi, Soichiro Yoshikawa, Yohei Kawano, Hajime Karasuyama: Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice. Int. Immunol.. 2019.02; 31 (1): 41-49. ( PubMed , DOI )

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Muraoka Naoto, Nara Kaori, Tamura Fumiya, Kojima Hidenori, Yamakawa Hiroyuki, Sadahiro Taketaro, Miyamoto Kazutaka, Isomi Mari, Haginiwa Sho, Tani Hidenori, Kurotsu Shota, Osakabe Rina, Torii Satoru, Shimizu Shigeomi, Okano Hideyuki, Sugimoto Yukihiko, Fukuda Keiichi, Ieda Masaki: Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming NATURE COMMUNICATIONS. 2019.02; 10 ( DOI )

Kei Takasawa, Atsumi Tsuji-Hosokawa, Shigeru Takishima, Yasunori Wada, Keisuke Nagasaki, Sumito Dateki, Chikahiko Numakura, Atsushi Hijikata, Tsuyoshi Shirai, Kenichi Kashimada, Tomohiro Morio: Clinical characteristics of adolescent cases with Type A insulin resistance syndrome caused by heterozygous mutations in the β-subunit of the insulin receptor (INSR) gene. J Diabetes. 2019.01; 11 (1): 46-54. ( PubMed , DOI )

Keiichi Iwanami, Tsubasa Okano, Osamu Ohara, Tomohiro Morio: Recurrent Acute Abdomen as the Main Manifestation of Hereditary Angioedema. Intern Med. 2019.01; 58 (2): 213-216. ( PubMed , DOI )

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Nagao Toshihisa, Yamanishi Yoshinori, Miyake Kensuke, Teranishi Mio, Takahashi Saori, Yoshikawa Soichiro, Kawano Yohei, Karasuyama Hajime: マウスにて好塩基球媒介性アレルギー誘発相において、蛋白質の凝集によって蛋白質がアレルゲン化する(Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice) International Immunology. 2019.01; 31 (1): 41-49. ( 医中誌 )

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Mari Kubota-Tanaka, Tomoo Osumi, Shouko Miura, Hiroshi Tsujimoto, Toshihiko Imamura, Akira Nishimura, Kentaro Oki, Kozue Nakamura, Satoshi Miyamoto, Kento Inoue, Maiko Inoue, Takahiro Kamiya, Masakatsu Yanagimachi, Tsubasa Okano, Noriko Mitsuiki, Takeshi Isoda, Kohsuke Imai, Hirokazu Kanegane, Tomohiro Morio, Shinji Kounami, Mikiya Endo, Motohiro Kato, Masatoshi Takagi: B-lymphoblastic lymphoma with the TCF3-PBX1 fusion gene. Haematologica. 2019.01; 104 (1): 35-37. ( PubMed , DOI )

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Yamaguchi Hiroki, Kamegawa Akiko, Nakata Kunio, Kashiwagi Tatsuki, Mizukoshi Toshimi, Fujiyoshi Yoshinori, Tani Kazutoshi: Structural insights into thermostabilization of leucine dehydrogenase from its atomic structure by cryo-electron microscopy JOURNAL OF STRUCTURAL BIOLOGY. 2019.01; 205 (1): 11-21. ( PubMed , DOI )

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Masatsune Tsujioka, Taro Q P Uyeda, Yoshiaki Iwadate, Hitesh Patel, Keitaro Shibata, Tenji Yumoto, Shigenobu Yonemura: Actin-binding domains mediate the distinct distribution of two Dictyostelium Talins through different affinities to specific subsets of actin filaments during directed cell migration. PLoS ONE. 2019; 14 (4): e0214736. ( PubMed , DOI )

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Hajime Karasuyama, Yuya Tabakawa, Takuya Ohta, Takeshi Wada, Soichiro Yoshikawa: Crucial Role for Basophils in Acquired Protective Immunity to Tick Infestation. Front Physiol. 2018.12; 9 1769. ( PubMed , DOI )

Sho Shibata, Kensuke Miyake, Tomoya Tateishi, Soichiro Yoshikawa, Yoshinori Yamanishi, Yasunari Miyazaki, Naohiko Inase, Hajime Karasuyama: Basophils trigger emphysema development in a murine model of COPD through IL-4-mediated generation of MMP-12-producing macrophages. Proc. Natl. Acad. Sci. U.S.A.. 2018.12; 115 (51): 13057-13062. ( PubMed , DOI )

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Nagatsuma M, Takasawa K, Yamauchi T, Nakagawa R, Mizuno T, Tanaka E, Yamamoto K, Uemura N, Kashimada K, Morio T: A postzygotic KRAS mutation in a patient with Schimmelpenning syndrome presenting with lipomatosis, renovascular hypertension, and diabetes mellitus. Journal of human genetics. 2018.11; ( PubMed , DOI )

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Tsurusaki Shinya, Matsuda Michitaka, Shimizu Shigeomi, Nakano Hiroyasu, Miyajima Atsushi, Tanaka Minoru: Elucidation of the Type of Cell Death at the Onset of Non-Alcoholic Steatohepatitis (NASH) HEPATOLOGY. 2018.10; 68 1023A-1024A.

Chikako Kamae, Kohsuke Imai, Tamaki Kato, Tsubasa Okano, Kenichi Honma, Noriko Nakagawa, Tzu-Wen Yeh, Emiko Noguchi, Akira Ohara, Tomonari Shigemura, Hiroshi Takahashi, Shunichi Takakura, Masatoshi Hayashi, Aoi Honma, Seiichi Watanabe, Tomoko Shigemori, Osamu Ohara, Hiroyuki Sasaki, Takeo Kubota, Tomohiro Morio, Hirokazu Kanegane, Shigeaki Nonoyama: Clinical and Immunological Characterization of ICF Syndrome in Japan. J. Clin. Immunol.. 2018.10; 38 (8): 927-937. ( PubMed , DOI )

Chelisa Cardinez, Bahar Miraghazadeh, Kay Tanita, Elizabeth da Silva, Akihiro Hoshino, Satoshi Okada, Rochna Chand, Takaki Asano, Miyuki Tsumura, Kenichi Yoshida, Hidenori Ohnishi, Zenichiro Kato, Masahide Yamazaki, Yusuke Okuno, Satoru Miyano, Seiji Kojima, Seishi Ogawa, T Daniel Andrews, Matthew A Field, Gaetan Burgio, Tomohiro Morio, Carola G Vinuesa, Hirokazu Kanegane, Matthew C Cook: Gain-of-function IKBKB mutation causes human combined immune deficiency. J. Exp. Med.. 2018.10; 215 (11): 2715-2724. ( PubMed , DOI )

Akihiro Hoshino, Xi Yang, Kay Tanita, Kenichi Yoshida, Toshiaki Ono, Naonori Nishida, Yusuke Okuno, Takeyuki Kanzaki, Kumiko Goi, Hisanori Fujino, Koichi Ohshima, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seishi Ogawa, Seiji Kojima, Tomohiro Morio, Hirokazu Kanegane: Modification of cellular and humoral immunity by somatically reverted T cells in X-linked lymphoproliferative syndrome type 1. J. Allergy Clin. Immunol.. 2018.10; 413 (1): 421-424. ( PubMed , DOI )

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Nobuhiro Fujikake, Minkyoung Shin, Shigeomi Shimizu: Association Between Autophagy and Neurodegenerative Diseases. Front Neurosci. 2018.09; 12 255. ( PubMed , DOI )

Karasuyama Hajime, Miyake Kensuke, Yoshikawa Soichiro, Kawano Yohei, Yamanishi Yoshinori: 好塩基球はいかにしてTh2細胞分化およびアレルギー反応に寄与するか?(How do basophils contribute to Th2 cell differentiation and allergic responses?) International Immunology. 2018.09; 30 (9): 391-396. ( 医中誌 )

Karasuyama Hajime, Miyake Kensuke, Yoshikawa Soichiro, Kawano Yohei, Yamanishi Yoshinori: How do basophils contribute to T(h)2 cell differentiation and allergic responses? INTERNATIONAL IMMUNOLOGY. 2018.09; 30 (9): 391-396. ( PubMed , DOI )

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Hajime Karasuyama, Kensuke Miyake, Soichiro Yoshikawa, Yoshinori Yamanishi: Multifaceted roles of basophils in health and disease. J. Allergy Clin. Immunol.. 2018.08; 142 (2): 370-380. ( PubMed , DOI )

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Yuya Tabakawa, Takuya Ohta, Soichiro Yoshikawa, Elisabeth J Robinson, Kayoko Yamaji, Kenji Ishiwata, Yohei Kawano, Kensuke Miyake, Yoshinori Yamanishi, Hiroshi Ohtsu, Takahiro Adachi, Naohiro Watanabe, Hirotaka Kanuka, Hajime Karasuyama: Histamine Released From Skin-Infiltrating Basophils but Not Mast Cells Is Crucial for Acquired Tick Resistance in Mice. Front Immunol. 2018.07; 9 1540. ( PubMed , DOI )

Akihiro Hoshino, Kay Tanita, Kenji Kanda, Ken-Ichi Imadome, Yoshiaki Shikama, Takahiro Yasumi, Kohsuke Imai, Masatoshi Takagi, Tomohiro Morio, Hirokazu Kanegane: High frequencies of asymptomatic Epstein-Barr virus viremia in affected and unaffected individuals with CTLA4 mutations. Clin. Immunol.. 2018.07; 195 45-48. ( PubMed , DOI )

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Asami Shimbo, Kei Takasawa, Masato Nishioka, Tomohiro Morio, Masayuki Shimohira: Complications of Listeria meningitis in two immunocompetent children. Pediatr Int. 2018.05; 60 (5): 491-492. ( PubMed , DOI )

Ryuichi Nakagawa, Atsumi Hosokawa-Tsuji, Yuki Aoki, Kei Takasawa, Mitsue Maru, Keisuke Nakajima, Akito Sutani, Yuichi Miyakawa, Daisuke Tomizawa, Kenichi Kashimada, Tomohiro Morio: Total body irradiation for hematopoietic stem cell transplantation during early childhood is associated with the risk for diabetes mellitus. Endocrine. 2018.04; 61 (1): 76-82. ( PubMed , DOI )

Okano T, Tsujita Y, Kanegane H, Mitsui-Sekinaka K, Tanita K, Miyamoto S, Yeh TW, Yamashita M, Terada N, Ogura Y, Takagi M, Imai K, Nonoyama S, Morio T.: Droplet Digital PCR-Based Chimerism Analysis for Primary Immunodeficiency Diseases. J. Clin. Immunol.. 2018.04; ( PubMed , DOI )

Asano T, Okada S, Tsumura M, Yeh TW, Mitsui-Sekinaka K, Tsujita Y, Ichinose Y, Shimada A, Hashimoto K, Wada T, Imai K, Ohara O, Morio T, Nonoyama S, Kobayashi M.: Enhanced AKT Phosphorylation of Circulating B Cells in Patients With Activated PI3Kδ Syndrome. Front Immunol. 2018.04; 9 568. ( PubMed , DOI )

Akihiro Hoshino, Takehiro Takashima, Kenichi Yoshida, Akira Morimoto, Yuta Kawahara, Tzu-Wen Yeh, Tsubasa Okano, Motoi Yamashita, Noriko Mitsuiki, Kohsuke Imai, Takashi Sakatani, Atsuko Nakazawa, Yusuke Okuno, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seishi Ogawa, Seiji Kojima, Tomohiro Morio, Hirokazu Kanegane: Dysregulation of Epstein-Barr virus infection in hypomorphic ZAP70 mutation J. Infect. Dis.. 2018.04; 218 (5): 825-834. ( PubMed , DOI )

Tomonori Kadowaki, Hidenori Ohnishi, Norio Kawamoto, Tomohiro Hori, Kenichi Nishimura, Chie Kobayashi, Tomonari Shigemura, Shohei Ogata, Yuzaburo Inoue, Tomoki Kawai, Eitaro Hiejima, Masatoshi Takagi, Kohsuke Imai, Ryuta Nishikomori, Shuichi Ito, Toshio Heike, Osamu Ohara, Tomohiro Morio, Toshiyuki Fukao, Hirokazu Kanegane: Haploinsufficiency of A20 causes autoinflammatory and autoimmune disorders. J Allergy Clin Immunol. 2018.04; 141 (4): 1485-1488.e11. ( PubMed , DOI )

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Yasuyoshi Ishiwata, Masashi Nagata, Kohta Tsuge, Hiromitsu Takahashi, Sayo Suzuki, Kohsuke Imai, Masatoshi Takagi, Hirokazu Kanegane, Tomohiro Morio, Masato Yasuhara: Population Pharmacokinetics of Intravenous Busulfan in Japanese Pediatric Patients With Primary Immunodeficiency Diseases. J Clin Pharmacol. 2018.03; 58 (3): 327-331. ( PubMed , DOI )

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Yuji Sugawara, Kohsuke Imai, Ayako Kashimada, Kengo Moriyama, Shimpei Baba, Ryuta Nishikomori, Mizuho Motegi, Yasuo Takeuchi, Tomohiro Morio: Autoinflammatory phenotypes in Aicardi-Goutières syndrome with interferon upregulation and serological autoimmune features J. Allergy Clin. Immunol. 2018.03; 141 (3): 1135-1138. ( PubMed , DOI )

Taro Watabe, Takashi Nagaishi, Naoya Tsugawa, Yudai Kojima, Nisha Jose, Akinori Hosoya, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Tetsuya Nakamura, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe: B cell activation in the cecal patches during the development of an experimental colitis model. Biochem. Biophys. Res. Commun.. 2018.02; 496 (2): 367-373. ( PubMed , DOI )

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Takasawa Kei, Nakagawa Ryuichi, Takishima Shigeru, Moriyama Kengo, Watanabe Ken, Kiyohara Koji, Hasegawa Takeshi, Shimohira Masahiro, Kashimada Kenichi, Shimizu Norio, Morio Tomohiro: 迅速かつ網羅的なウイルス検査システムによって診断した日本人小児の急性脳炎/脳症の原因と臨床症状の違い(Cause of acute encephalitis/encephalopathy in Japanese children diagnosed by a rapid and comprehensive virological detection system and differences in their clinical presentations) Brain & Development. 2018.02; 40 (2): 107-115. ( 医中誌 )

Ryuichi Nakagawa, Kei Takasawa, Tzu-Wen Yeh, Kohsuke Imai, Kenichi Kashimada, Tomohiro Morio: Type 1 Diabetes Mellitus Associated with Activated Phosphoinositide-3-kinase Delta Syndrome, Type 2. J Diabetes. 2018.02; 10 (5): 421-422. ( PubMed , DOI )

Christophe Pellefigues, Barbara Dema, Yasmine Lamri, Fanny Saidoune, Nathalie Chavarot, Charlotte Lohéac, Emeline Pacreau, Michael Dussiot, Caroline Bidault, Florian Marquet, Mathieu Jablonski, Jonathan M Chemouny, Fanny Jouan, Antoine Dossier, Marie-Paule Chauveheid, Delphine Gobert, Thomas Papo, Hajime Karasuyama, Karim Sacré, Eric Daugas, Nicolas Charles: Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs. Nat Commun. 2018.02; 9 (1): 725. ( PubMed , DOI )

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Hidefumi Iwashita, Hajime Tajima Sakurai, Noriyoshi Nagahora, Munetaka Ishiyama, Kosei Shioji, Kazumi Sasamoto, Kentaro Okuma, Shigeomi Shimizu, Yuichiro Ueno: Small fluorescent molecules for monitoring autophagic flux. FEBS Lett.. 2018.02; 592 (4): 559-567. ( PubMed , DOI )

Tomokazu Yamaguchi, Takashi Suzuki, Teruki Sato, Akinori Takahashi, Hiroyuki Watanabe, Ayumi Kadowaki, Miyuki Natsui, Hideaki Inagaki, Satoko Arakawa, Shinji Nakaoka, Yukio Koizumi, Shinsuke Seki, Shungo Adachi, Akira Fukao, Toshinobu Fujiwara, Tohru Natsume, Akinori Kimura, Masaaki Komatsu, Shigeomi Shimizu, Hiroshi Ito, Yutaka Suzuki, Josef M Penninger, Tadashi Yamamoto, Yumiko Imai, Keiji Kuba: The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Sci Signal. 2018.02; 11 (516): ( PubMed , DOI )

Ayako Kashimada, Setsuko Hasegawa, Takeo Isagai, Tsuyoshi Uchiyama, Muneaki Matsuo, Motoharu Kawai, Masahide Goto, Tomohiro Morio, Yukiko K Hayashi, Masatoshi Takagi: Targeting the enhanced ER stress response in Marinesco-Sjögren syndrome J. Neurol. Sci.. 2018.02; 385 49-56. ( PubMed , DOI )

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Toshihiro Matsui, Takumi Matsumoto, Fumio Hirano, Fumika Tokunaga, Keisuke Okamoto, Shigeto Tohma, Tomohiro Morio, Hitoshi Kohsaka, Masaaki Mori: Survey of the awareness of adult rheumatologists regarding transitional care for patients with juvenile idiopathic arthritis in Japan Mod Rheumatol. 2018.01; 28 (6): 981-985. ( PubMed , DOI )

Kei Takasawa, Maki Igarashi, Makoto Ono, Akira Takemoto, Shuji Takada, Atsuyuki Yamataka, Tsutomu Ogata, Tomohiro Morio, Maki Fukami, Kenichi Kashimada: Phenotypic Variation in 46,XX Disorders of Sex Development due to the NR5A1 p.R92W Variant: A Sibling Case Report and Literature Review Sex Dev. 2018.01; 11 (5-6): 284-288. ( PubMed , DOI )

Kohno Takashi, Shimizu Shigeomi: New therapeutic ways for new precision cancer medicine: Vulnerability of cancer cells CANCER SCIENCE. 2018.01; 109 942.

Hirokazu Kanegane, Akihiro Hoshino, Tsubasa Okano, Takahiro Yasumi, Taizo Wada, Hidetoshi Takada, Satoshi Okada, Motoi Yamashita, Tzu-Wen Yeh, Ryuta Nishikomori, Masatoshi Takagi, Kohsuke Imai, Hans D Ochs, Tomohiro Morio: Flow cytometry-based diagnosis of primary immunodeficiency diseases Allergol Int. 2018.01; ( PubMed , DOI )

Atsumi Tsuji-Hosokawa, Kei Takasawa, Risa Nomura, Yuichi Miyakawa, Chikahiko Numakura, Atsushi Hijikata, Tsuyoshi Shirai, Yoshihiro Ogawa, Kenichi Kashimada, Tomohiro Morio: Molecular mechanisms of insulin resistance in 2 cases of primary insulin receptor defect-associated diseases. Pediatr Diabetes. 2017.12; ( PubMed , DOI )

Akiyama Shintaro, Mochizuki Wakana, Nibe Yoichi, Matsumoto Yuka, Sakamoto Kei, Oshima Shigeru, Watanabe Mamoru, Nakamura Tetsuya: マウス結腸杯細胞集団にて、CCN3発現は独特なスルホムチン非産生亜細胞集団を標識する(CCN3 Expression Marks a Sulfomucin-nonproducing Unique Subset of Colonic Goblet Cells in Mice) Acta Histochemica et Cytochemica. 2017.12; 50 (6): 159-168. ( 医中誌 )

Kojima Toshiyuki, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime: Mucosal-Skin Immunity(2) Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 3-F. ( 医中誌 )

Takahiro Adachi, Yoshikawa Soichiro, Karasuyama Hajime: B cell development and function Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 3-E. ( 医中誌 )

Karasuyama Hajime: Allergy: state-of-the-art Emerging roles of basophils in allergic inflammation and immune regulation(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): S1-4. ( 医中誌 )

Miyake Kensuke, Shiozawa Nozomu, Nagao Toshihisa, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime: Granulocyte & Mast cells Basophils exert antigen presentation via trogocytosis-mediated acquisition of peptide-MHC class II complexes from dendritic cells(DCs)(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 3-H. ( 医中誌 )

SHIBATA Sho, MIYAKE Kensuke, YOSHIKAWA Soichiro, KAWANO Yohei, YAMANISHI Yoshinori, KARASUYAMA Hajime: Allergy: Lower airway allergic inflammation Monocyte-derived macrophages in the lung contribute to the development of pulmonary emphysema through MMP-12 production in a mouse model of COPD(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 1-A. ( 医中誌 )

Yamanishi Yoshinori, Iki Misako, Tanaka Kensei, Deki Hayato, Fujimaki Mio, Miyake Kensuke, Yoshikawa Soichiro, Kawano Yohei, Sato Shingo, Karasuyama Hajime: Allergy: Allergic dermatitis, food allergy and allergic conjunctivitis Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 2-G. ( 医中誌 )

本田 真也, 清水 重臣: オートファジーは中心体数を制御することで腫瘍形成を抑制する 生命科学系学会合同年次大会. 2017.12; 2017年度 [1P-1001]. ( 医中誌 )

Aziz Bousfiha, Leïla Jeddane, Capucine Picard, Fatima Ailal, H Bobby Gaspar, Waleed Al-Herz, Talal Chatila, Yanick J Crow, Charlotte Cunningham-Rundles, Amos Etzioni, Jose Luis Franco, Steven M Holland, Christoph Klein, Tomohiro Morio, Hans D Ochs, Eric Oksenhendler, Jennifer Puck, Mimi L K Tang, Stuart G Tangye, Troy R Torgerson, Jean-Laurent Casanova, Kathleen E Sullivan: The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies. J. Clin. Immunol. 2017.12; 38 (1): 129-143. ( PubMed , DOI )

Capucine Picard, H Bobby Gaspar, Waleed Al-Herz, Aziz Bousfiha, Jean-Laurent Casanova, Talal Chatila, Yanick J Crow, Charlotte Cunningham-Rundles, Amos Etzioni, Jose Luis Franco, Steven M Holland, Christoph Klein, Tomohiro Morio, Hans D Ochs, Eric Oksenhendler, Jennifer Puck, Mimi L K Tang, Stuart G Tangye, Troy R Torgerson, Kathleen E Sullivan: International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity. J. Clin. Immunol. 2017.12; 38 (1): 96-128. ( PubMed , DOI )

Kazuo Takayama, Naoki Akita, Natsumi Mimura, Rina Akahira, Yukimasa Taniguchi, Makoto Ikeda, Fuminori Sakurai, Osamu Ohara, Tomohiro Morio, Kiyotoshi Sekiguchi, Hiroyuki Mizuguchi: Generation of safe and therapeutically effective human induced pluripotent stem cell-derived hepatocyte-like cells for regenerative medicine Hepatol Commun. 2017.12; 1 (10): 1058-1069. ( PubMed , DOI )

Masayuki Nagasawa, Noriko Mitsuiki, Yuki Aoki, Toshiaki Ono, Takeshi Isoda, Kohsuke Imai, Masatoshi Takagi, Michiko Kajiwara, Hirokazu Kanegane, Tomohiro Morio: Effect of reduced-intensity conditioning and the risk of late-onset non-infectious pulmonary complications in pediatric patients Eur. J. Haematol. 2017.12; 99 (6): 525-531. ( PubMed , DOI )

Yoichi Nibe, Shigeru Oshima, Masanori Kobayashi, Chiaki Maeyashiki, Yu Matsuzawa, Kana Otsubo, Hiroki Matsuda, Emi Aonuma, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Shinichiro Nakada, Mamoru Watanabe: Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by SQSTM1/p62. Autophagy. 2017.11; 14 (2): 1-43. ( PubMed , DOI )

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Satoshi Yotsumoto, Yuito Muroi, Tatsuya Chiba, Rio Ohmura, Maki Yoneyama, Megumi Magarisawa, Kosuke Dodo, Naoki Terayama, Mikiko Sodeoka, Ryohei Aoyagi, Makoto Arita, Satoko Arakawa, Shigeomi Shimizu, Masato Tanaka: Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation. Sci Rep. 2017.11; 7 (1): 16026. ( PubMed , DOI )

Miyamoto Satoshi, Takagi Masatoshi, Nishimura Akira, Tanaka Mari, Ono Shintaro, Ashiarai Miho, Mitsuiki Noriko, Hoshino Akihiro, Yanagimachi Masakatsu, Aoki Yuki, Tomizawa Daisuke, Imai Kohsuke, Kajiwara Michiko, Kanegane Hirokazu, Morio Tomohiro: A 7-year-old Girl who Maintains Complete Remission after Multiple Hematopoietic Cell Transplantation for Frequent Relapse of Infant Leukemia PEDIATRIC BLOOD & CANCER. 2017.11; 64 S92-S93.

Masatoshi Takagi, Misa Yoshida, Yoshino Nemoto, Hiroyuki Tamaichi, Rika Tsuchida, Masafumi Seki, Kumiko Uryu, Noriko Hoshino, Rina Nishii, Satoshi Miyamoto, Masahiro Saito, Toshiaki Shimizu, Ryoji Hanada, Hideo Kaneko, Toshiyuki Fukao, Takatoshi Koyama, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Yusuke Sato, Yoichi Fujii, Keisuke Kataoka, Yusuke Okuno, Kenichi Yoshida, Tomohiro Morio, Akira Oka, Miki Ohira, Yasuhide Hayashi, Akira Nakagawara, Seishi Ogawa, Shuki Mizutani, Junko Takita.: Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor. J. Natl. Cancer Inst.. 2017.11; 109 (11): ( PubMed , DOI )

Shuya Kasai, Mary Jane Elizabeth Richardson, Satoru Torii, Ken-Ichi Yasumoto, Hiroki Shima, Kazuhiko Igarashi, Ken Itoh, Kazuhiro Sogawa, Kazutaka Murayama: Increase in pro-apoptotic activity of inhibitory PAS domain protein via phosphorylation by MK2. FEBS Journal. 2017.10; 284 (23): 4115-4127. ( PubMed , DOI )

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Hidefumi Iwashita, Satoru Torii, Noriyoshi Nagahora, Munetaka Ishiyama, Kosei Shioji, Kazumi Sasamoto, Shigeomi Shimizu, Kentaro Okuma: Live Cell Imaging of Mitochondrial Autophagy with a Novel Fluorescent Small Molecule. ACS Chem. Biol.. 2017.10; 12 (10): 2546-2551. ( PubMed , DOI )

Kei Takasawa, Ryuichi Nakagawa, Shigeru Takishima, Kengo Moriyama, Ken Watanabe, Koji Kiyohara, Takeshi Hasegawa, Masahiro Shimohira, Kenichi Kashimada, Norio Shimizu, Tomohiro Morio: Cause of acute encephalitis/encephalopathy in Japanese children diagnosed by a rapid and comprehensive virological detection system and differences in their clinical presentations. Brain Dev. 2017.10; 40 (2): 107-115. ( PubMed , DOI )

Shimpei Baba, Ayumi Kobayashi, Haruna Yokoyama, Kengo Moriyama, Ayako Kashimada, Jun Oyama, Ayako Owada, Shoichi Oyama, Tomohiro Morio, Masatoshi Takagi: Slowly progressive leukodystrophy in an adolescent male with phosphoglycerate kinase deficiency. Brain Dev. 2017.10; 40 (2): 150-154. ( PubMed , DOI )

Tomohiro Morio: Recent advances in the study of immunodeficiency and DNA damage response. Int. J. Hematol. 2017.10; 106 (3): 357-365. ( PubMed , DOI )

Akira Endo, Miko Okamura, Shunsuke Yoshikawa, Yasuhiro Otomo, Tomohiro Morio: Multilateral Functional Alterations of Human Neutrophils in Sepsis: From the Point of Diagnosis to the Seventh Day. Shock. 2017.10; 48 (6): 629-637. ( PubMed , DOI )

Tsubasa Okano, Takuro Nishikawa, Eri Watanabe, Takashi Watanabe, Takehiro Takashima, Tzu-Wen Yeh, Motoi Yamashita, Mari Tanaka-Kubota, Satoshi Miyamoto, Noriko Mitsuiki, Masatoshi Takagi, Yoshifumi Kawano, Yoshiki Mochizuki, Kohsuke Imai, Hirokazu Kanegane, Tomohiro Morio: Maternal T and B cell engraftment in two cases of X-linked severe combined immunodeficiency with IgG1 gammopathy. Clin. Immunol. 2017.10; 183 112-120. ( PubMed , DOI )

清水 重臣: がん個別化医療の革新を目指す新規治療戦略　がんの脆弱性 オートファジー細胞死を誘導する新規抗がん剤の開発 日本癌学会総会記事. 2017.09; 76回 S18-1. ( 医中誌 )

Hidefumi Iwashita , Satoru Torii, Noriyoshi Nagahora, Munetaka Ishiyama, Kosei Shioji, Kazumi Sasamoto, Shigeomi Shimizu, and Kentaro Okuma: Live Cell Imaging of Mitochondrial Autophagy with a Novel Fluorescent Small Molecule ACS Chem. Biol.. 2017.09;

Jumpei Asano, Taku Sato, Shizuko Ichinose, Mihoko Kajita, Nobuyuki Onai, Shigeomi Shimizu, and Toshiaki Ohteki : Intrinsic autophagy is required for the maintenance of intestinal stem cells and for irradiation-induced intestinal regeneration Cell Reports. 2017.09;

Satoko Arakawa, Shinya Honda, Hirofumi Yamaguchi, Shigeomi Shimizu: Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy Proceedings of the Japan Academy, Series B. 2017.09;

Charline Miot, Kohsuke Imai, Chihaya Imai, Anthony J Mancini, Zeynep Yesim Kucuk, Tokomki Kawai, Ryuta Nishikomori, Etsuro Ito, Isabelle Pellier, Sophie Dupuis Girod, Jeremie Rosain, Shinya Sasaki, Shanmuganathan Chandrakasan, Jana Pachlopnik Schmid, Tsubasa Okano, Estelle Colin, Alberto Olaya-Vargas, Marco Yamazaki-Nakashimada, Waseem Qasim, Sara Espinosa Padilla, Andrea Jones, Alfons Krol, Nyree Cole, Stephen Jolles, Jack Bleesing, Thomas Vraetz, Andrew R Gennery, Mario Abinun, Tayfun Güngör, Beatriz Costa-Carvalho, Antonio Condino-Neto, Paul Veys, Steven M Holland, Gulbu Uzel, Despina Moshous, Benedicte Neven, Stéphane Blanche, Stephan Ehl, Rainer Döffinger, Smita Y Patel, Anne Puel, Jacinta Bustamante, Erwin W Gelfand, Jean-Laurent Casanova, Jordan S Orange, Capucine Picard: Hematopoietic stem cell transplantation in 29 patients hemizygous for hypomorphic IKBKG/NEMO mutations Blood. 2017.09; 130 (12): 1456-1467. ( PubMed , DOI )

Kanemoto K, Sugimura Y, Shimizu S, Yoshida S, Hosoya T: Rhodium-catalyzed odorless synthesis of diaryl sulfides from borylarenes and #IS#IR-aryl thiosulfonates. Chem Commun. 2017.09; 53 (77): 10640-10643. ( PubMed , DOI )

Johanna Schepp, Janet Chou, Andrea Skrabl-Baumgartner, Peter D Arkwright, Karin R Engelhardt, Sophie Hambleton, Tomohiro Morio, Ekkehard Röther, Klaus Warnatz, Raif Geha, Bodo Grimbacher: 14 Years after Discovery: Clinical Follow-up on 15 Patients with Inducible Co-Stimulator Deficiency. Front Immunol. 2017.08; 8 964. ( PubMed , DOI )

Jumpei Asano, Taku Sato, Shizuko Ichinose, Mihoko Kajita, Nobuyuki Onai, Shigeomi Shimizu, Toshiaki Ohteki: Intrinsic Autophagy Is Required for the Maintenance of Intestinal Stem Cells and for Irradiation-Induced Intestinal Regeneration. Cell Rep. 2017.08; 20 (5): 1050-1060. ( PubMed , DOI )

Barbara Dema, Yasmine Lamri, Christophe Pellefigues, Emeline Pacreau, Fanny Saidoune, Caroline Bidault, Hajime Karasuyama, Karim Sacré, Eric Daugas, Nicolas Charles: Basophils contribute to pristane-induced Lupus-like nephritis model. Sci Rep. 2017.08; 7 (1): 7969. ( PubMed , DOI )

Masayuki Nagasawa, Teppei Ohkawa, Masatoshi Takagi, Kohsuke Imai, Tomohiro Morio: A Stable Mixed Chimera After SCT with RIC in an Infant with IκBα Hypermorphic Mutation. J. Clin. Immunol.. 2017.07; 37 (5): 413-414. ( PubMed , DOI )

Yoshinori Yamanishi, Kensuke Miyake, Misako Iki, Hidemitsu Tsutsui, Hajime Karasuyama: Recent advances in understanding basophil-mediated Th2 immune responses. Immunol. Rev.. 2017.07; 278 (1): 237-245. ( PubMed , DOI )

Miyake Kensuke, Karasuyama Hajime: アレルギー性炎症における好塩基球の新たな役割(Beyond Th2, More than ILC2　Emerging roles of basophils in allergic inflammation) Allergology International. 2017.07; 66 (3): 382-391. ( 医中誌 )

Akihiro Hoshino, Satoshi Okada, Kenichi Yoshida, Naonori Nishida, Yusuke Okuno, Hiroo Ueno, Motoi Yamashita, Tsubasa Okano, Miyuki Tsumura, Shiho Nishimura, Sonoko Sakata, Masao Kobayashi, Haruna Nakamura, Junji Kamizono, Kanako Mitsui-Sekinaka, Takuya Ichimura, Shouichi Ohga, Yozo Nakazawa, Masatoshi Takagi, Kohsuke Imai, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seishi Ogawa, Seiji Kojima, Shigeaki Nonoyama, Tomohiro Morio, Hirokazu Kanegane: Abnormal hematopoiesis and autoimmunity in human subjects with germline IKZF1 mutations. J Allergy Clin Immunol. 2017.07; 140 (1): 223-231. ( PubMed , DOI )

Sumika Toyama, Naoko Okada, Akio Matsuda, Hideaki Morita, Hirohisa Saito, Takao Fujisawa, Susumu Nakae, Hajime Karasuyama, Kenji Matsumoto: Human eosinophils constitutively express a unique serine protease, PRSS33. Allergol Int. 2017.07; 66 (3): 463-471. ( PubMed , DOI )

Tomoyuki Bando, Setsuko Fujita, Naoko Nagano, Soichiro Yoshikawa, Yoshinori Yamanishi, Masashi Minami, Hajime Karasuyama: Differential usage of COX-1 and COX-2 in prostaglandin production by mast cells and basophils. Biochem Biophys Rep. 2017.07; 10 82-87. ( PubMed , DOI )

Taizo Wada, Satoshi Miyamoto, Hiroyuki Okamoto, Yusuke Matsuda, Tomoko Toma, Kohsuke Imai, Masatoshi Takagi, Tomohiro Morio, Akihiro Yachie: Prolonged neutropenia due to antihuman neutrophil antigen 2 (CD177) antibody after bone marrow transplantation Pediatr Blood Cancer. 2017.07; 64 (7): ( PubMed , DOI )

Kensuke Miyake, Hajime Karasuyama: Emerging roles of basophils in allergic inflammation. Allergol. Int.. 2017.07; 66 (3): 382-391. ( PubMed , DOI )

Ayumi Kobayashi, Reiko Takasawa, Kei Takasawa, Masato Nishioka, Masahide Kaneko, Hiroshi Ono, Takanobu Maekawa, Tomohiro Morio, Masayuki Shimohira: An infant case of severe hypereosinophilia and systemic symptoms with multiple drug hypersensitivity and reactivation of cytomegalovirus and BK virus. Allergol Int. 2017.07; 66 (3): 479-481. ( PubMed , DOI )

Takehiro Takashima, Miko Okamura, Tzu-Wen Yeh, Tsubasa Okano, Motoi Yamashita, Keisuke Tanaka, Akihiro Hoshino, Noriko Mitsuiki, Masatoshi Takagi, Eiichi Ishii, Kohsuke Imai, Hirokazu Kanegane, Tomohiro Morio: Multicolor Flow Cytometry for the Diagnosis of Primary Immunodeficiency Diseases J. Clin. Immunol. 2017.07; 37 (5): 486-495. ( PubMed , DOI )

Yujin Sekinaka, Noriko Mitsuiki, Kohsuke Imai, Miharu Yabe, Hiromasa Yabe, Kanako Mitsui-Sekinaka, Kenichi Honma, Masatoshi Takagi, Ayako Arai, Kenichi Yoshida, Yusuke Okuno, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Hideki Muramatsu, Seiji Kojima, Asuka Hira, Minoru Takata, Osamu Ohara, Seishi Ogawa, Tomohiro Morio, Shigeaki Nonoyama: Common Variable Immunodeficiency Caused by FANC Mutations. J. Clin. Immunol. 2017.07; 37 (5): 434-444. ( PubMed , DOI )

Satoko Arakawa, Masatsune Tsujioka, Tatsushi Yoshida, Hajime Tajima-Sakurai, Yuya Nishida, Yosuke Matsuoka, Ikuyo Yoshino, Yoshihide Tsujimoto, Shigeomi Shimizu: Role of Atg5-dependent cell death in the embryonic development of Bax/Bak double-knockout mice. Cell Death Differ.. 2017.06; 24 (9): 1598-1608. ( PubMed , DOI )

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Ikumi Hori, Takanobu Otomo, Mitsuko Nakashima, Fuyuki Miya, Yutaka Negishi, Hideaki Shiraishi, Yutaka Nonoda, Shinichi Magara, Jun Tohyama, Nobuhiko Okamoto, Takeshi Kumagai, Konomi Shimoda, Yoshiya Yukitake, Daigo Kajikawa, Tomohiro Morio, Ayako Hattori, Motoo Nakagawa, Naoki Ando, Ichizo Nishino, Mitsuhiro Kato, Tatsuhiko Tsunoda, Hirotomo Saitsu, Yonehiro Kanemura, Mami Yamasaki, Kenjiro Kosaki, Naomichi Matsumoto, Tamotsu Yoshimori, Shinji Saitoh: Defects in autophagosome-lysosome fusion underlie Vici syndrome, a neurodevelopmental disorder with multisystem involvement. Sci Rep. 2017.06; 7 (1): 3552. ( PubMed , DOI )

Arakawa Satoko, Honda Shinya, Yamaguchi Hirofumi, Shimizu Shigeomi: Atg5/Atg7非依存的代替オートファジーの分子機序と生理的役割(Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy) Proceedings of the Japan Academy Series B, Physical and Biological Sciences. 2017.06; 93 (6): 378-384. ( 医中誌 )

Yamanishi Yoshinori, Iki Misako, Tanaka Kensei, Deki Hayato, Fujimaki Mio, Sato Shingo, Yoshikawa Soichiro, Karasuyama Hajime: IgE介在性慢性アレルギー性炎症において好塩基球性トリプターゼmMCP-11は重要な役割を果たす(Basophil tryptase mMCP-11 plays a crucial role in the IgE-mediated chronic allergic inflammation) アレルギー. 2017.05; 66 (4-5): 520. ( 医中誌 )

Masatoshi Takagi, Yasuyoshi Ishiwata, Yuki Aoki, Satoshi Miyamoto, Akihiro Hoshino, Kazuaki Matsumoto, Akira Nishimura, Mari Tanaka, Masakatsu Yanagimachi, Noriko Mitsuiki, Kohsuke Imai, Hirokazu Kanegane, Michiko Kajiwara, Kanako Takikawa, Tsukasa Mae, Osamu Tomita, Junya Fujimura, Masato Yasuhara, Daisuke Tomizawa, Shuki Mizutani, Tomohiro Morio: HLA haploidentical hematopoietic cell transplantation using clofarabine and busulfan for refractory pediatric hematological malignancy. Int J Hematol. 2017.05; 105 (5): 686-691. ( PubMed , DOI )

Nienke J H van Os, Anne F M Jansen, Marcel van Deuren, Asgeir Haraldsson, Nieke T M van Driel, Amos Etzioni, Michiel van der Flier, Charlotte A Haaxma, Tomohiro Morio, Amit Rawat, Michiel H D Schoenaker, Annarosa Soresina, Alexander M R Taylor, Bart P C van de Warrenburg, Corry M R Weemaes, Nel Roeleveld, Michèl A A P Willemsen: Ataxia-telangiectasia: Immunodeficiency and survival. Clin. Immunol.. 2017.05; 178 45-55. ( PubMed , DOI )

Haruna Yokoyama, Shimpei Baba, Jun Oyama, Kengo Moriyama, Tomohiro Morio: Early hypoperfusion on arterial spin labeling may be a diagnostic marker for acute encephalopathy with biphasic seizures and late reduced diffusion. Brain Dev.. 2017.05; 39 (8): 722. ( PubMed , DOI )

Satoko Arakawa, Shinya Honda, Satoru Torii, Masatsune Tsujioka, Shigeomi Shimizu: Monitoring of Atg5-Independent Mitophagy. Methods Mol. Biol.. 2017.04; 1759 125-132. ( PubMed , DOI )

Kaori Mukai, Hajime Karasuyama, Kenji Kabashima, Masato Kubo, Stephen J Galli: Differences in the Importance of Mast Cells, Basophils, IgE, and IgG versus That of CD4+ T Cells and ILC2 Cells in Primary and Secondary Immunity to Strongyloides venezuelensis. Infect. Immun.. 2017.04; 85 (5): e00053-17. ( PubMed , DOI )

Shimpei Baba, Yuji Sugawara, Kengo Moriyama, Motoki Inaji, Taketoshi Maehara, Toshiyuki Yamamoto, Tomohiro Morio: Amelioration of intractable epilepsy by adjunct vagus nerve stimulation therapy in a girl with a CDKL5 mutation. Brain Dev. 2017.04; 39 (4): 341-344. ( PubMed , DOI )

Chiaki Maeyashiki, Shigeru Oshima, Kana Otsubo, Masanori Kobayashi, Yoichi Nibe, Yu Matsuzawa, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe: HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells. Biochem. Biophys. Res. Commun.. 2017.03; 484 (3): 636-641. ( PubMed , DOI )

Tatsuya Kozaki, Jun Komano, Daiki Kanbayashi, Michihiro Takahama, Takuma Misawa, Takashi Satoh, Osamu Takeuchi, Taro Kawai, Shigeomi Shimizu, Yoshiharu Matsuura, Shizuo Akira, Tatsuya Saitoh: Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response. Proc. Natl. Acad. Sci. U.S.A.. 2017.03; 114 (10): 2681-2686. ( PubMed , DOI )

Shinya Honda, Shigeomi Shimizu: Autophagy controls centrosome number. Oncotarget. 2017.02; 8 (9): 14277-14278. ( PubMed , DOI )

Bianca Balbino, Riccardo Sibilano, Philipp Starkl, Thomas Marichal, Nicolas Gaudenzio, Hajime Karasuyama, Pierre Bruhns, Mindy Tsai, Laurent L Reber, Stephen J Galli: Pathways of immediate hypothermia and leukocyte infiltration in an adjuvant-free mouse model of anaphylaxis. J. Allergy Clin. Immunol.. 2017.02; 139 (2): 584-596.e10. ( PubMed , DOI )

Chikako Morioka, Motohiro Komaki, Atsuko Taki, Izumi Honda, Naoki Yokoyama, Kengo Iwasaki, Sachiko Iseki, Tomohiro Morio, Ikuo Morita: Neuroprotective effects of human umbilical cord-derived mesenchymal stem cells on periventricular leukomalacia-like brain injury in neonatal rats. Inflamm Regen. 2017.01; 37 1. ( PubMed , DOI )

Shintaro Ono, Tsubasa Okano, Akihiro Hoshino, Masakatsu Yanagimachi, Kazuko Hamamoto, Yozo Nakazawa, Toshihiko Imamura, Masaei Onuma, Hidetaka Niizuma, Yoji Sasahara, Hiroshi Tsujimoto, Taizo Wada, Reiko Kunisaki, Masatoshi Takagi, Kohsuke Imai, Tomohiro Morio, Hirokazu Kanegane: Hematopoietic Stem Cell Transplantation for XIAP Deficiency in Japan. J. Clin. Immunol. 2017.01; 37 (1): 85-91. ( PubMed , DOI )

Atsumi Tsuji-Hosokawa, Nozomi Matsuda, Kenji Kurosawa, Kenichi Kashimada, Tomohiro Morio: A Case of MECP2 Duplication Syndrome with Gonadotropin-Dependent Precocious Puberty. Horm Res Paediatr. 2017.01; 87 (4): 217-216. ( PubMed , DOI )

Hidemitsu Tsutsui, Yoshinori Yamanishi, Hiromi Ohtsuka, Shingo Sato, Soichiro Yoshikawa, Hajime Karasuyama: The Basophil-specific Protease mMCP-8 Provokes an Inflammatory Response in the Skin with Microvascular Hyperpermeability and Leukocyte Infiltration. J. Biol. Chem.. 2017.01; 292 (3): 1061-1067. ( PubMed , DOI )

Kensuke Miyake, Nozomu Shiozawa, Toshihisa Nagao, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama: Trogocytosis of peptide-MHC class II complexes from dendritic cells confers antigen-presenting ability on basophils. Proc. Natl. Acad. Sci. U.S.A.. 2017.01; 114 (5): 1111-1116. ( PubMed , DOI )

Akiyama Shintaro, Mochizuki Wakana, Nibe Yoichi, Matsumoto Yuka, Sakamoto Kei, Oshima Shigeru, Watanabe Mamoru, Nakamura Tetsuya: CCN3 Expression Marks a Sulfomucin-nonproducing Unique Subset of Colonic Goblet Cells in Mice ACTA HISTOCHEMICA ET CYTOCHEMICA. 2017; 50 (6): 159-168. ( PubMed , DOI )

Arakawa S, Honda S, Yamaguchi H, Shimizu S.: Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy. Proceedinds of the Japan Academy,Series B.. 2017;

Katsutsugu Umeda, Souichi Adachi, Shiro Tanaka, Mizuka Miki, Keiko Okada, Yoshiko Hashii, Masami Inoue, Yuko Cho, Katsuyoshi Koh, Hiroaki Goto, Ryosuke Kajiwara, Nobuyuki Hyakuna, Koji Kato, Tomohiro Morio, Hiromasa Yabe, : Comparison of second transplantation and donor lymphocyte infusion for donor mixed chimerism after allogeneic stem cell transplantation for nonmalignant diseases. Pediatr Blood Cancer. 2016.12; 63 (12): 2221-2229. ( PubMed , DOI )

Akifumi Endo, Daisuke Tomizawa, Yuki Aoki, Tomohiro Morio, Shuki Mizutani, Masatoshi Takagi: EWSR1/ELF5 induces acute myeloid leukemia by inhibiting p53/p21 pathway. Cancer Sci.. 2016.12; 107 (12): 1745-1754. ( PubMed , DOI )

Yuki Tsujita, Kanako Mitsui-Sekinaka, Kohsuke Imai, Tzu-Wen Yeh, Noriko Mitsuiki, Takaki Asano, Hidenori Ohnishi, Zenichiro Kato, Yujin Sekinaka, Kiyotaka Zaha, Tamaki Kato, Tsubasa Okano, Takehiro Takashima, Kaoru Kobayashi, Mitsuaki Kimura, Tomoaki Kunitsu, Yoshihiro Maruo, Hirokazu Kanegane, Masatoshi Takagi, Kenichi Yoshida, Yusuke Okuno, Hideki Muramatsu, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seiji Kojima, Seishi Ogawa, Osamu Ohara, Satoshi Okada, Masao Kobayashi, Tomohiro Morio, Shigeaki Nonoyama: Phosphatase and tensin homolog (PTEN) mutation can cause activated phosphatidylinositol 3-kinase δ syndrome-like immunodeficiency. J. Allergy Clin. Immunol.. 2016.12; 138 (6): 1672-1680. ( PubMed , DOI )

Iki, M., Tanaka, K., Deki, H. Fujimaki, M., Sato, S., Yoshikawa, S., Yamanishi, Y., Karasuyama, K.: Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation in mice. Blood. 2016.12; 128 (25): 2909-2918. ( PubMed , DOI )

Shigeru Takishima, Keisuke Nakajima, Risa Nomura, Atsumi Tsuji-Hosokawa, Nozomi Matsuda, Yohei Matsubara, Makoto Ono, Kentaro Miyai, Kei Takasawa, Tomohiro Morio, Yukihiro Hasegawa, Kenichi Kashimada: Lower body weight and BMI at birth were associated with early adiposity rebound in 21-hydroxylase deficiency patients. Endocr. J.. 2016.11; 63 (11): 983-990. ( PubMed , DOI )

Toshiyuki Kojima, Kiichiro Tsuchiya, Shinji Ikemizu, Soichiro Yoshikawa, Yoshinori Yamanishi, Mamoru Watanabe, Hajime Karasuyama: Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R. Sci Rep. 2016.11; 6 36457. ( PubMed , DOI )

Satoru Torii, Tatsushi Yoshida, Satoko Arakawa, Shinya Honda, Akira Nakanishi, Shigeomi Shimizu: Identification of PPM1D as an essential Ulk1 phosphatase for genotoxic stress-induced autophagy. EMBO Rep.. 2016.11; 17 (11): 1552-1564. ( PubMed , DOI )

Yuichiro Watanabe, Shinya Honda, Akimitsu Konishi, Satoko Arakawa, Michiko Murohashi, Hirofumi Yamaguchi, Satoru Torii, Minoru Tanabe, Shinji Tanaka, Eiji Warabi, Shigeomi Shimizu: Autophagy controls centrosome number by degrading Cep63. Nat Commun. 2016.11; 7 13508. ( PubMed , DOI )

Masanori Kobayashi, Shigeru Oshima, Chiaki Maeyashiki, Yoichi Nibe, Kana Otsubo, Yu Matsuzawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe: The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development. Sci Rep. 2016.11; 6 36780. ( PubMed , DOI )

Venturelli, N., Lexmond, W. S., Ohsaki, A., Nurko, S., Karasuyama, H., Fiebiger, E., Oyoshi, M. K.: Allergic skin sensitization promotes eosinophilic esophagitis through the IL-33-basophil axis in mice. J. Allergy Clin. Immunol.. 2016.11; 138 (5): 1367-1380.e5. ( PubMed , DOI )

Shumpei Yokota, Yasuhiko Itoh, Tomohiro Morio, Hideki Origasa, Naokata Sumitomo, Minako Tomobe, Kunihiko Tanaka, Seiji Minota: Tocilizumab in systemic juvenile idiopathic arthritis in a real-world clinical setting: results from 1 year of postmarketing surveillance follow-up of 417 patients in Japan. Ann. Rheum. Dis.. 2016.10; 75 (9): 1654-1660. ( PubMed , DOI )

Takeshi Sato, Tsubasa Okano, Mari Tanaka-Kubota, Shunsuke Kimura, Satoshi Miyamoto, Shintaro Ono, Motoi Yamashita, Noriko Mitsuiki, Masatoshi Takagi, Kohsuke Imai, Michiko Kajiwara, Takasuke Ebato, Shohei Ogata, Hirotsugu Oda, Osamu Ohara, Hirokazu Kanegane, Tomohiro Morio: Novel compound heterozygous mutations in a Japanese girl with Janus kinase 3 deficiency. Pediatr Int. 2016.10; 58 (10): 1076-1080. ( PubMed , DOI )

Horiguchi, K., Yoshikawa, S., Saito, A., Haddad, S., Ohta, T., Miyake, K., Yamanishi, Y., Karasuyama, H.: Real-time imaging of mast cell degranulation in vitro and in vivo. Biochem. Biophys. Res. Commun.. 2016.10; 479 (3): 517-522. ( PubMed , DOI )

Schiechl, G., Hermann, F.J., Rodriguez Gomez, M., Kutzi, S., Schmidbauer, K., Talke, Y., Neumayer, S., Goebel, N., Renner, K., Brühl, H., Karasuyama, H., Obata-Ninomiya, K., K Utpatel, K., Evert, M., Hirt, S.W., Geissler, E.K., Fichtner-Feigl, S., Mack, M.: Basophils Trigger Fibroblast Activation in Cardiac Allograft Fibrosis Development. Am. J. Transplant.. 2016.09; 16 (9): 2574-2588. ( PubMed , DOI )

Yamanishi, Y., Karasuyama, H.: Basophils and mast cells in immunity and inflammation. Semin Immunopathol. 2016.09; 38 (5): 535-537. ( PubMed , DOI )

Yamanishi, Y., Karasuyama, H.: Basophil-derived IL-4 plays versatile roles in immunity. Semin Immunopathol. 2016.09; 38 (5): 615-622. ( PubMed , DOI )

Hirofumi Yamaguchi, Satoko Arakawa, Toku Kanaseki, Takeshi Miyatsuka, Yoshio Fujitani, Hirotaka Watada, Yoshihide Tsujimoto, Shigeomi Shimizu: Golgi membrane-associated degradation pathway in yeast and mammals. EMBO J.. 2016.09; 35 (18): 1991-2007. ( PubMed , DOI )

Akimitsu Konishi, Takashi Izumi, Shigeomi Shimizu: TRF2 Protein Interacts with Core Histones to Stabilize Chromosome Ends. J. Biol. Chem.. 2016.09; 291 (39): 20798-20810. ( PubMed , DOI )

Taichi Matsumoto, Wakana Mochizuki, Yoichi Nibe, Shintaro Akiyama, Yuka Matsumoto, Kengo Nozaki, Masayoshi Fukuda, Ayumi Hayashi, Tomohiro Mizutani, Shigeru Oshima, Mamoru Watanabe, Tetsuya Nakamura: Retinol Promotes In Vitro Growth of Proximal Colon Organoids through a Retinoic Acid-Independent Mechanism. PLoS ONE. 2016.08; 11 (8): e0162049. ( PubMed , DOI )

Uchiyama H, Uehara K, Nagashima T, Nakata A, Sato K, Mihara Y, Komatsu KI, Takanari J, Shimizu S, Wakame K: Global Liver Gene Expression Analysis on a Murine Metabolic Syndrome Model Treated by Low-molecular-weight Lychee Fruit Polyphenol (Oligonol®). Anticancer research. 2016.07; 36 (7): 3705-13. ( PubMed )

Tatsushi Yoshida, Masatsune Tsujioka, Shinya Honda, Masato Tanaka, Shigeomi Shimizu: Autophagy suppresses cell migration by degrading GEF-H1, a RhoA GEF. Oncotarget. 2016.06; 7 (23): 34420-34429. ( PubMed , DOI )

Yusuke Nasu, Alexander Benke, Satoko Arakawa, Go J Yoshida, Genki Kawamura, Suliana Manley, Shigeomi Shimizu, Takeaki Ozawa: In Situ Characterization of Bak Clusters Responsible for Cell Death Using Single Molecule Localization Microscopy. Sci Rep. 2016.06; 6 27505. ( PubMed , DOI )

Baba, T., Tanabe, Y., Yoshikawa, S., Yamanishi, Y., Morishita, S., Komatsu, N., Karasuyama, H., Hirao, A., Mukaida N.: MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice. Blood. 2016.05; 127 (21): 2607-2617. ( PubMed , DOI )

Masakatsu Yanagimachi, Takashi Ohya, Tomoko Yokosuka, Ryosuke Kajiwara, Fumiko Tanaka, Hiroaki Goto, Takehiro Takashima, Tomohiro Morio, Shumpei Yokota: The Potential and Limits of Hematopoietic Stem Cell Transplantation for the Treatment of Autosomal Dominant Hyper-IgE Syndrome. J. Clin. Immunol.. 2016.04; 36 (5): 511-516. ( PubMed , DOI )

Julie Toubiana, Satoshi Okada, Julia Hiller, Matias Oleastro, Macarena Lagos Gomez, Juan Carlos Aldave Becerra, Marie Ouachée-Chardin, Fanny Fouyssac, Katta Mohan Girisha, Amos Etzioni, Joris Van Montfrans, Yildiz Camcioglu, Leigh Ann Kerns, Bernd Belohradsky, Stéphane Blanche, Aziz Bousfiha, Carlos Rodriguez-Gallego, Isabelle Meyts, Kai Kisand, Janine Reichenbach, Ellen D Renner, Sergio Rosenzweig, Bodo Grimbacher, Frank L van de Veerdonk, Claudia Traidl-Hoffmann, Capucine Picard, Laszlo Marodi, Tomohiro Morio, Masao Kobayashi, Desa Lilic, Joshua D Milner, Steven Holland, Jean-Laurent Casanova, Anne Puel: Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype: an international survey of 274 patients from 167 kindreds. Blood. 2016.04; 127 (25): 3154-3164. ( PubMed , DOI )

T Muto, Y Takeda, S Tsukamoto, S Sakai, N Mimura, C Ohwada, M Takeuchi, E Sakaida, S Ota, T Iseki, N Shimizu, T Morio, C Nakaseko: Successful treatment of cytomegalovirus enteritis after unrelated allogeneic stem cell transplantation by the infusion of ex vivo-expanded CD4(+) lymphocytes derived from the recipient's peripheral blood donor cells. Transpl Infect Dis. 2016.02; 18 (1): 93-97. ( PubMed , DOI )

Kazuhiro Ikegame, Kohsuke Imai, Motoi Yamashita, Akihiro Hoshino, Hirokazu Kanegane, Tomohiro Morio, Katsuji Kaida, Takayuki Inoue, Toshihiro Soma, Hiroya Tamaki, Masaya Okada, Hiroyasu Ogawa: Allogeneic stem cell transplantation for X-linked agammaglobulinemia using reduced intensity conditioning as a model of the reconstitution of humoral immunity. J Hematol Oncol. 2016.02; 9 (1): 9. ( PubMed , DOI )

A Arai, C Sakashita, C Hirose, K-I Imadome, M Yamamoto, M Jinta, S Fujiwara, M Tomita, N Shimizu, T Morio, O Miura: Hematopoietic stem cell transplantation for adults with EBV-positive T- or NK-cell lymphoproliferative disorders: efficacy and predictive markers. Bone Marrow Transplant.. 2016.02; 51 (6): 879-882. ( PubMed , DOI )

Yumiko Nakano, Takeshi Hayashi, Kentaro Deguchi, Kota Sato, Nozomi Hishikawa, Toru Yamashita, Yasuyuki Ohta, Yoshiki Takao, Tomohiro Morio, Koji Abe: Two young stroke patients associated with regular intravenous immunoglobulin (IVIg) therapy. J. Neurol. Sci.. 2016.02; 361 9-12. ( PubMed , DOI )

Kei Takasawa, Sayaka Takeda, Masato Nishioka, Hiroshi Sakuma, Tomohiro Morio, Masayuki Shimohira: Steroid-responsive Status Epilepticus Caused by Human Parvovirus B19 Encephalitis. Pediatr. Infect. Dis. J.. 2016.02; 35 (2): 227-228. ( PubMed , DOI )

Seiichi Hayakawa, Satoshi Okada, Miyuki Tsumura, Sonoko Sakata, Yoshitaka Ueno, Kohsuke Imai, Tomohiro Morio, Osamu Ohara, Kazuaki Chayama, Masao Kobayashi: A Patient with CTLA-4 Haploinsufficiency Presenting Gastric Cancer. J. Clin. Immunol.. 2016.01; 36 (1): 28-32. ( PubMed , DOI )

Yoshikawa, S., Usami, T., Kikuta, J., Ishii, M., Sasano, T., Sugiyama, K., Furukawa, T., Nakasho, E., Takayanagi, H., Tedder, T. F., Karasuyama, H., Miyawaki, A., Adachi, T.: Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset. Sci Rep. 2016.01; 6 18738. ( PubMed , DOI )

Laura Gámez-Díaz, Dietrich August, Polina Stepensky, Shoshana Revel-Vilk, Markus G Seidel, Mitsuiki Noriko, Tomohiro Morio, Austen J J Worth, Jacob Blessing, Frank Van de Veerdonk, Tobias Feuchtinger, Maria Kanariou, Annette Schmitt-Graeff, Sophie Jung, Suranjith Seneviratne, Siobhan Burns, Bernd H Belohradsky, Nima Rezaei, Shahrzad Bakhtiar, Carsten Speckmann, Michael Jordan, Bodo Grimbacher: The extended phenotype of LPS-responsive beige-like anchor protein (LRBA) deficiency. J. Allergy Clin. Immunol.. 2016.01; 137 (1): 223-230. ( PubMed , DOI )

Yuki Aoki, Reiji Miyawaki, Kohsuke Imai, Masatoshi Takagi, Michiko Kajiwara, Yasuyoshi Ishiwata, Masato Yasuhara, Tomohiro Morio, Shuki Mizutani, Daisuke Tomizawa: Haploidentical Bone Marrow Transplantation With Clofarabine and Busulfan Conditioning for a Child With Multiple Recurrent Acute Lymphoblastic Leukemia. J. Pediatr. Hematol. Oncol.. 2016.01; 38 (1): 39-41. ( PubMed , DOI )

T Wada, Toma T, M Yasui, M Inoue, K Kawa, K Imai, T Morio, A Yachie: Different Clinical Phenotypes in 2 Siblings With X-Linked Severe Combined Immunodeficiency. J Investig Allergol Clin Immunol. 2016; 26 (1): 63-65. ( PubMed )

Adachi, T., Kakuta, S., Aihara, Y., Kamiya, T., Watanabe, Y., Osakabe, N., Hazato, N., Miyawaki, A., Yoshikawa, S., Usami, T., Karasuyama, H., Kimoto-Nira, H., Hirayama, K., M Tsuji, N.: Visualization of Probiotic-Mediated Ca(2+) Signaling in Intestinal Epithelial Cells In Vivo. Front Immunol. 2016; 7 601. ( PubMed , DOI )

Tomohiro Kohmoto, Atsumi Tsuji, Kei-Ichi Morita, Takuya Naruto, Kiyoshi Masuda, Kenichi Kashimada, Keisuke Enomoto, Tomohiro Morio, Hiroyuki Harada, Issei Imoto: A novel COL11A1 missense mutation in siblings with non-ocular Stickler syndrome. Hum Genome Var. 2016; 3 16003. ( PubMed , DOI )

Kotaro Kai, Maki Sumida, Yaeko Motoyoshi, Yuichi Ogawa, Katsuyuki Miki, Kazuhiro Iwadoh, Akihito Sannomiya, Toru Murakami, Ichiro Koyama, Kumiko Kitajima, Ichiro Nakajima, Tomohiro Morio, Shohei Fuchinoue: Successful Long-term Graft Survival of a Renal Transplantation Patient with Wiskott-Aldrich Syndrome. Intern. Med.. 2016; 55 (13): 1761-1763. ( PubMed , DOI )

Uchiyama H, Uehara K, Nagashima T, Nakata A, Sato K, Mihara Y, Komatsu K, Takanari J, Shimizu S, Wakame K.: Global Liver Gene Expression Analysisi on a Murine Metabolic Syndrome Model Treated by Low-molecular-weight Lychee Fruit Polyphenol. Anticancer Research.. 2016; 36 (7): 3705-3713.

Atsumi Tsuji, Kaoru Konishi, Satomi Hasegawa, Akira Anazawa, Toshikazu Onishi, Makoto Ono, Tomohiro Morio, Teruo Kitagawa, Kenichi Kashimada: Newborn screening for congenital adrenal hyperplasia in Tokyo, Japan from 1989 to 2013: a retrospective population-based study. BMC Pediatr. 2015.12; 15 (1): 209. ( PubMed , DOI )

遠藤彰,吉川俊輔,大友康裕,森尾友宏: 重症敗血症・敗血症性ショックにおける好中球機能の変化の検討 バイオメディカル. 2015.12; 25 2-8. ( 医中誌 )

LiHua, L., Yoshikawa, S., Ohta, T., Horiguchi, K., Kawano, Y., Ohtsu, H., Yamanishi, Y., and Karasuyama, H.: Large particulate allergens can elicit mast cell-mediated anaphylaxis without exit from blood vessels as efficiently as do small soluble allergens. Biochem. Biophys. Res. Commun. . 2015.11; 467 (6 (1)): 70-75. ( PubMed )

Keisuke Nakajima, Shinobu Hirai, Tomohiro Morio, Haruo Okado: Benzodiazepines induce sequelae in immature mice with inflammation-induced status epilepticus. Epilepsy Behav. 2015.10; 52 (Pt A): 180-186. ( PubMed , DOI )

Kei Takasawa, Shigeru Takishima, Chikako Morioka, Masato Nishioka, Hirofumi Ohashi, Yoko Aoki, Masayuki Shimohira, Kenichi Kashimada, Tomohiro Morio: Improved growth velocity of a patient with Noonan-like syndrome with loose anagen hair (NS/LAH) without growth hormone deficiency by low-dose growth hormone therapy. Am. J. Med. Genet. A. 2015.10; 167A (10): 2425-2429. ( PubMed , DOI )

Shinobu Tamura, Kohei Higuchi, Masaharu Tamaki, Chizuko Inoue, Ryoko Awazawa, Noriko Mitsuki, Yuka Nakazawa, Hiroyuki Mishima, Kenzo Takahashi, Osamu Kondo, Kohsuke Imai, Tomohiro Morio, Osamu Ohara, Tomoo Ogi, Fukumi Furukawa, Masami Inoue, Koh-Ichiro Yoshiura, Nobuo Kanazawa: Novel compound heterozygous DNA ligase IV mutations in an adolescent with a slowly-progressing radiosensitive-severe combined immunodeficiency. Clin. Immunol.. 2015.10; 160 (2): 255-260. ( PubMed , DOI )

Takao Hayakawa, Takashi Aoi, Christopher Bravery, Karin Hoogendoorn, Ivana Knezevic, Junichi Koga, Daisuke Maeda, Akifumi Matsuyama, James McBlane, Tomohiro Morio, John Petricciani, Mahendra Rao, Anthony Ridgway, Daisaku Sato, Yoji Sato, Glyn Stacey, Norihisa Sakamoto, Jean-Hugues Trouvin, Akihiro Umezawa, Masayuki Yamato, Kazuo Yano, Hiroyuki Yokote, Kentaro Yoshimatsu, Pierrette Zorzi-Morre: Report of the international conference on regulatory endeavors towards the sound development of human cell therapy products. Biologicals. 2015.09; 43 (5): 283-297. ( PubMed , DOI )

S Kasai, S Torii, A Kakita, K Sogawa: Inhibitory PAS domain protein is a substrate of PINK1 and Parkin and mediates cell death in a Parkinson's disease model. Cell Death Disease. 2015.09; 6 e1886. ( PubMed , DOI )

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S Torii, S Kasai, A Suzuki, Y Todoroki, K Yokozawa, K-I Yasumoto, N Seike, H Kiyonari, Y Mukumoto, A Kakita, K Sogawa: Involvement of inhibitory PAS domain protein in neuronal cell death in Parkinson's disease. Cell Death Discovery. 2015.08; 1 15015. ( PubMed , DOI )

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Yu Matsuzawa, Shigeru Oshima, Masahiro Takahara, Chiaki Maeyashiki, Yasuhiro Nemoto, Masanori Kobayashi, Yoichi Nibe, Kengo Nozaki, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Averil Ma, Mamoru Watanabe: TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy. Autophagy. 2015.06; 11 (7): 1052-1062. ( PubMed , DOI )

Tomoya Muto, Chikako Ohwada, Atsuko Yamazaki, Yasumasa Sugita, Shokichi Tsukamoto, Shio Sakai, Yusuke Takeda, Naoya Mimura, Masahiro Takeuchi, Emiko Sakaida, Tohru Iseki, Norio Shimizu, Tomohiro Morio, Chiaki Nakaseko: Long-term complete remission by infusion of ex vivo-expanded donor-derived CD4(+) lymphocytes for treating an early relapse of Hodgkin lymphoma after cord blood transplantation. Leuk. Lymphoma. 2015.05; 1-11. ( PubMed , DOI )

Yohei Matsubara, Tomoko Kato, Kenichi Kashimada, Hiromitsu Tanaka, Zhou Zhi, Shizuko Ichinose, Shuki Mizutani, Tomohiro Morio, Tomoki Chiba, Yoshiaki Ito, Yumiko Saga, Shuji Takada, Hirhoshi Asahara: TALEN-mediated gene disruption on Y Chromosome reveals Critical Role of EIF2S3Y in Mouse Spermatogenesis. Stem Cells Dev.. 2015.05; 24 (10): 1164-1170. ( PubMed , DOI )

Go Matsuda, Ken-Ichi Imadome, Fuyuko Kawano, Masashi Mochizuki, Nakaba Ochiai, Tomohiro Morio, Norio Shimizu, Shigeyoshi Fujiwara: Cellular immunotherapy with ex vivo expanded cord blood T cells in a humanized mouse model of EBV-associated lymphoproliferative disease. Immunotherapy. 2015.04; 7 (4): 335-341. ( PubMed , DOI )

Shumpei Yokota, Yasuhiko Itoh, Tomohiro Morio, Naokata Sumitomo, Kaori Daimaru, Seiji Minota: Macrophage Activation Syndrome in Patients with Systemic Juvenile Idiopathic Arthritis under Treatment with Tocilizumab. J. Rheumatol.. 2015.04; 42 (4): 712-722. ( PubMed , DOI )

Tamaki Kato, Elena Crestani, Chikako Kamae, Kenichi Honma, Tomoko Yokosuka, Takeshi Ikegawa, Naonori Nishida, Hirokazu Kanegane, Taizo Wada, Akihiro Yachie, Osamu Ohara, Tomohiro Morio, Luigi D Notarangelo, Kohsuke Imai, Shigeaki Nonoyama: RAG1 Deficiency May Present Clinically as Selective IgA Deficiency. J. Clin. Immunol.. 2015.04; 35 (3): 280-288. ( PubMed , DOI )

Noriko Mitsuiki, Xi Yang, Sophinus J W Bartol, Christina Grosserichter-Wagener, Yoshiyuki Kosaka, Hidetoshi Takada, Kohsuke Imai, Hirokazu Kanegane, Shuki Mizutani, Mirjam van der Burg, Menno C van Zelm, Osamu Ohara, Tomohiro Morio: Mutations in Bruton's tyrosine kinase impair IgA responses. Int. J. Hematol.. 2015.03; 101 (3): 305-313. ( PubMed , DOI )

Kanako Mitsui-Sekinaka, Kohsuke Imai, Hiroki Sato, Daisuke Tomizawa, Michiko Kajiwara, Masayuki Nagasawa, Tomohiro Morio, Shigeaki Nonoyama: Clinical features and hematopoietic stem cell transplantations for CD40 ligand deficiency in Japan. J. Allergy Clin. Immunol.. 2015.03; 136 (4): 1018-1024. ( PubMed , DOI )

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Teppei Ohkawa, Satoshi Miyamoto, Manabu Sugie, Daisuke Tomizawa, Kohsuke Imai, Masayuki Nagasawa, Tomohiro Morio, Shuki Mizutani, Masatoshi Takagi: Transient abnormal myelopoiesis in non-Down syndrome neonate. Pediatr Int. 2015.02; 57 (1): 14-17. ( PubMed , DOI )

Hikaru Ito, Kyota Fujita, Kazuhiko Tagawa, Xigui Chen, Hidenori Homma, Toshikazu Sasabe, Jun Shimizu, Shigeomi Shimizu, Takuya Tamura, Shin-ichi Muramatsu, Hitoshi Okazawa: HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice. EMBO Mol Med. 2015.01; 7 (1): 78-101. ( PubMed , DOI )

Yu Matsuzawa, Shigeru Oshima, Yoichi Nibe, Masanori Kobayashi, Chiaki Maeyashiki, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe: RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62. Biochem. Biophys. Res. Commun.. 2015.01; 456 (1): 298-304. ( PubMed , DOI )

Koichi Oshima, Kohsuke Imai, Michael H Albert, Tanja C Bittner, Gabriele Strauss, Alexandra H Filipovich, Tomohiro Morio, Neena Kapoor, Jignesh Dalal, Kirk R Schultz, James T Casper, Luigi D Notarangelo, Hans D Ochs, Shigeaki Nonoyama: Hematopoietic Stem Cell Transplantation for X-Linked Thrombocytopenia With Mutations in the WAS gene. J. Clin. Immunol.. 2015.01; 35 (1): 15-21. ( PubMed , DOI )

Yun-Wen Chen, Tianhuan Guo, Lijun Shen, Kai-Yau Wong, Qian Tao, William W. L. Choi, Rex K. H. Au-Yeung, Yuen-Piu Chan, Michelle L. Y. Wong, Johnny C. O. Tang, Wei-Ping Liu, Gan-Di Li, Norio Shimizu, Florence Loong, Eric Tse, Yok-Lam Kwong and Gopesh Srivastava. : Receptor-type tyrosine-protein phosphatase k directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma. Blood . 2015; 125 1589-1600.

Yoshimori M, Takada H, Imadome K, Kurata M, Yamamoto K, Koyama T, Shimizu N, Fujiwara S, Miura O, Arai A: P-glycoprotein is expressed and causes resistance to chemotherapy in EBV-positive T-cell lymphoproliferative diseases. Cancer Med. . 2015; 4 1494-1504.

Inazawa N, Hori T, Yamamoto M, Hatakeyama N, Yoto Y, Nojima M, Yasui H, Suzuki N, Shimizu N, Tsutsumi H. : HHV-6 encephalitis may complicate the early phase after allogeneic hematopoietic stem cell transplantation: Detection by qualitative multiplex PCR and subsequent quantitative real-time PCR. J Med Virol. 2015;

Inazawa N, Hori T, Hatakeyama N, Yamamoto M, Yoto Y, Nojima M, Suzuki N, Shimizu N, Tsutsumi H: Large-scale multiplex polymerase chain reaction assay for diagnosis of viral reactivations after allogeneic hematopoietic stem cell transplantation. J Med Virol. . 2015; 87 1427-1435.

S. Yoshida, Y. Sugimura, Y. Hazama, Y. Nishiyama, T. Yano, S. Shimizu, T.Hosoya. : A mild and facile synthesis of aryl and alkenyl sulfides via copper-catalyzed deborylthiolation of organoborons with thiosulfonates. Chemical Commun. 2015; 51 16613-16616.

S. Arakawa, I. Nakanomyo, Y. Kudo-Sakamoto, H. Akazawa, I. Komuro, S. Shimizu.: Identification of a novel compound that inhibits both mitochondria-mediated necrosis and apoptosis. Biochem. Biophys. Res. Commun. 2015; 467 1006-1011.

S. Yoshida, T. Yano, Y. Misawa, Y. Sugimura, K. Igawa, S. Shimizu, K. Tomooka, T. Hosoya. : Direct Thioamination of Arynes via Reaction with Sulfilimines and Migratory N-Arylation. J. Am. Chem. Soc. . 2015; 137 14071-14074.

Matsuda G, Imadome K, Kawano F, Mochizuki M, Ochiai N, Morio T, Shimizu N, Fujiwara S. : Cellular immunotherapy with ex vivo expanded cord blood T cells in a humanized mouse model of EBV-associated lymphoproliferative disease. Immunotherapy. Immunotherapy. . 2015; 7 335-341.

Tomohito Takimoto, Hidetoshi Takada, Masataka Ishimura, Makiko Kirino, Kenichiro Hata, Osamu Ohara, Tomohiro Morio, Toshiro Hara: Wiskott-Aldrich Syndrome in a Girl Caused by Heterozygous WASP Mutation and Extremely Skewed X-Chromosome Inactivation: A Novel Association with Maternal Uniparental Isodisomy 6. Neonatology. 2015; 107 (3): 185-190. ( PubMed , DOI )

Hajime Karasuyama, Yoshinori Yamanishi: Basophils have emerged as a key player in immunity. Curr. Opin. Immunol.. 2014.12; 31 1-7. ( PubMed , DOI )

Tae-Yoon Park, Sung-Dong Park, Jen-Young Cho, Jae-Seung Moon, Na-Yeon Kim, Kyungsoo Park, Rho Hyun Seong, Sang-Won Lee, Tomohiro Morio, Alfred L M Bothwell, Sang-Kyou Lee: RORγt-specific transcriptional interactomic inhibition suppresses autoimmunity associated with TH17 cells. Proc. Natl. Acad. Sci. U.S.A.. 2014.12; 111 (52): 18673-18678. ( PubMed , DOI )

Yasuhiro Yamazaki, Masafumi Yamada, Toshinao Kawai, Tomohiro Morio, Masafumi Onodera, Masahiro Ueki, Nobuyuki Watanabe, Hidetoshi Takada, Shunichiro Takezaki, Natsuko Chida, Ichiro Kobayashi, Tadashi Ariga: Two novel gain-of-function mutations of STAT1 responsible for chronic mucocutaneous candidiasis disease: impaired production of IL-17A and IL-22, and the presence of anti-IL-17F autoantibody. J. Immunol.. 2014.11; 193 (10): 4880-4887. ( PubMed , DOI )

Masaaki Mori, Masafumi Onodera, Akira Morimoto, Yoshiyuki Kosaka, Tomohiro Morio, Gerard F Notario, Shringi Sharma, Tsutomu Saji: Palivizumab use in Japanese infants and children with immunocompromised conditions. Pediatr. Infect. Dis. J.. 2014.11; 33 (11): 1183-1185. ( PubMed , DOI )

Laurent L Reber, Thomas Marichal, Jeremy Sokolove, Philipp Starkl, Nicolas Gaudenzio, Yoichiro Iwakura, Hajime Karasuyama, Lawrence B Schwartz, William H Robinson, Mindy Tsai, Stephen J Galli: Contribution of mast cell-derived interleukin-1β to uric acid crystal-induced acute arthritis in mice. Arthritis and Rheumatology (Hoboken, N.J.). 2014.10; 66 (10): 2881-2891. ( PubMed , DOI )

K Nakatani, K Imai, M Shigeno, H Sato, M Tezuka, T Okawa, N Mitsuiki, T Isoda, D Tomizawa, M Takagi, M Nagasawa, M Kajiwara, M Yamamoto, A Arai, O Miura, C Kamae, N Nakagawa, K Honma, S Nonoyama, S Mizutani, T Morio: Cord blood transplantation is associated with rapid B-cell neogenesis compared with BM transplantation. Bone Marrow Transplant.. 2014.09; 49 (9): 1155-1161. ( PubMed , DOI )

Masaaki Mori, Tomohiro Morio, Shuichi Ito, Akira Morimoto, Setsuo Ota, Koichi Mizuta, Tsutomu Iwata, Toshiro Hara, Tsutomu Saji: Risks and prevention of severe RS virus infection among children with immunodeficiency and Down's syndrome. J. Infect. Chemother.. 2014.08; 20 (8): 455-459. ( PubMed , DOI )

Akifumi Endo, Ken Watanabe, Tamae Ohye, Kyoko Suzuki, Tomoyo Matsubara, Norio Shimizu, Hiroki Kurahashi, Tetsushi Yoshikawa, Harutaka Katano, Naoki Inoue, Kohsuke Imai, Masatoshi Takagi, Tomohiro Morio, Shuki Mizutani: Molecular and Virological Evidence of Viral Activation From Chromosomally Integrated Human Herpesvirus 6A in a Patient With X-Linked Severe Combined Immunodeficiency. Clin. Infect. Dis.. 2014.08; 59 (4): 545-548. ( PubMed , DOI )

Akihiro Hoshino, Kohsuke Imai, Yusei Ohshima, Motoko Yasutomi, Masashi Kasai, Masaru Terai, Keiko Ishigaki, Tomohiro Morio, Toshio Miyawaki, Hirokazu Kanegane: Pneumothorax in patients with severe combined immunodeficiency. Pediatr Int. 2014.08; 56 (4): 510-514. ( PubMed , DOI )

Kei Takasawa, Makoto Ono, Atsushi Hijikata, Yohei Matsubara, Noriyuki Katsumata, Masatoshi Takagi, Tomohiro Morio, Osamu Ohara, Kenichi Kashimada, Shuki Mizutani: Two novel HSD3B2 missense mutations with diverse residual enzymatic activities for Δ5-steroids. Clin. Endocrinol. (Oxf). 2014.06; 80 (6): 782-789. ( PubMed , DOI )

Jungim Kim, Atsushi Mizokami, Minkyoung Shin, Kouji Izumi, Hiroyuki Konaka, Yoshifumi Kadono, Yasuhide Kitagawa, Evan T Keller, Jian Zhang, Mikio Namiki: SOD3 acts as a tumor suppressor in PC-3 prostate cancer cells via hydrogen peroxide accumulation. Anticancer Res.. 2014.06; 34 (6): 2821-2831. ( PubMed )

Mahbubul Morshed, Ruslan Hlushchuk, Dagmar Simon, Andrew F Walls, Kazushige Obata-Ninomiya, Hajime Karasuyama, Valentin Djonov, Alexander Eggel, Thomas Kaufmann, Hans-Uwe Simon, Shida Yousefi: NADPH oxidase-independent formation of extracellular DNA traps by basophils. J. Immunol.. 2014.06; 192 (11): 5314-5323. ( PubMed , DOI )

Shinya Honda, Satoko Arakawa, Yuya Nishida, Hirofumi Yamaguchi, Eiichi Ishii, Shigeomi Shimizu. : Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes. Nature Communications. 2014.06; 5 4004.

Nadja Bakocevic, Carla Claser, Soichiro Yoshikawa, Leigh Ann Jones, Samantha Chew, Chi Ching Goh, Benoit Malleret, Anis Larbi, Florent Ginhoux, Maria Curotto de Lafaille, Hajime Karasuyama, Laurent Renia, Lai Guan Ng: CD41 is a reliable identification and activation marker for murine basophils in the steady state and during helminth and malarial infections. Eur. J. Immunol.. 2014.06; 44 (6): 1823-1834. ( PubMed , DOI )

Shimizu S, Honda S, Arakawa S, Yamaguchi H: Alternative macroautophagy and mitophagy. Int J Biochem Cell Biol. 2014.05; 50 64-66. ( PubMed , DOI )

Shin Fukuda, Toshihiro Nanki, Tomohiro Morio, Hisanori Hasegawa, Ryuji Koike, Nobuyuki Miyasaka: Recurrent mitral valve regurgitation with neutrophil infiltration in a patient with multiple aseptic abscesses. Mod Rheumatol. 2014.05; 24 (3): 537-539. ( PubMed , DOI )

Kei Takasawa, Kenichi Kashimada, Emanuele Pelosi, Masatoshi Takagi, Tomohiro Morio, Hiroshi Asahara, David Schlessinger, Shuki Mizutani, Peter Koopman: FOXL2 transcriptionally represses Sf1 expression by antagonizing WT1 during ovarian development in mice. FASEB J.. 2014.05; 28 (5): 2020-2028. ( PubMed , DOI )

Setsuko Hasegawa, Kohsuke Imai, Kenichi Yoshida, Yusuke Okuno, Hideki Muramatsu, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seiji Kojima, Seishi Ogawa, Tomohiro Morio, Shuki Mizutani, Masatoshi Takagi: Whole-exome sequence analysis of ataxia telangiectasia-like phenotype. J. Neurol. Sci.. 2014.05; 340 (1-2): 86-90. ( PubMed , DOI )

Yoko Mizoguchi, Miyuki Tsumura, Satoshi Okada, Osamu Hirata, Shizuko Minegishi, Kohsuke Imai, Nobuyuki Hyakuna, Hideki Muramatsu, Seiji Kojima, Yusuke Ozaki, Takehide Imai, Sachiyo Takeda, Tetsuya Okazaki, Tsuyoshi Ito, Shin'ichiro Yasunaga, Yoshihiro Takihara, Vanessa L Bryant, Xiao-Fei Kong, Sophie Cypowyj, Stéphanie Boisson-Dupuis, Anne Puel, Jean-Laurent Casanova, Tomohiro Morio, Masao Kobayashi: Simple diagnosis of STAT1 gain-of-function alleles in patients with chronic mucocutaneous candidiasis. J. Leukoc. Biol.. 2014.04; 95 (4): 667-676. ( PubMed , DOI )

Beatriz E Marciano, Chiung-Yu Huang, Gyan Joshi, Nima Rezaei, Beatriz Costa Carvalho, Zoe Allwood, Aydan Ikinciogullari, Shereen M Reda, Andrew Gennery, Vojtech Thon, Francisco Espinosa-Rosales, Waleed Al-Herz, Oscar Porras, Anna Shcherbina, Anna Szaflarska, Şebnem Kiliç, Jose L Franco, Andrea C Gómez Raccio, Persio Roxo, Isabel Esteves, Nermeen Galal, Anete Sevciovic Grumach, Salem Al-Tamemi, Alisan Yildiran, Julio C Orellana, Masafumi Yamada, Tomohiro Morio, Diana Liberatore, Yoshitoshi Ohtsuka, Yu-Lung Lau, Ryuta Nishikomori, Carlos Torres-Lozano, Juliana T L Mazzucchelli, Maria M S Vilela, Fabiola S Tavares, Luciana Cunha, Jorge A Pinto, Sara E Espinosa-Padilla, Leticia Hernandez-Nieto, Reem A Elfeky, Tadashi Ariga, Heike Toshio, Figen Dogu, Funda Cipe, Renata Formankova, M Enriqueta Nuñez-Nuñez, Liliana Bezrodnik, Jose Gonçalo Marques, María I Pereira, Viviana Listello, Mary A Slatter, Zohreh Nademi, Danuta Kowalczyk, Thomas A Fleisher, Graham Davies, Bénédicte Neven, Sergio D Rosenzweig: BCG vaccination in patients with severe combined immunodeficiency: complications, risks, and vaccination policies. J. Allergy Clin. Immunol.. 2014.04; 133 (4): 1134-1141. ( PubMed , DOI )

Shigeyoshi Fujiwara, Hiroshi Kimura, Ken-ichi Imadome, Ayako Arai, Eiichi Kodama, Tomohiro Morio, Norio Shimizu, Hiroshi Wakiguchi: Current research on chronic active Epstein-Barr virus infection in Japan. Pediatr Int. 2014.04; 56 (2): 159-166. ( PubMed , DOI )

S. Shimizu, S. Honda, S. Arakawa, H. Yamaguchi,: Alternative Macroautophagy and Mitophagy　 Int. J. Biochem. Cell Biol. . 2014.03; 50 64-66.

S. Shimizu, T. Yoshida, M. Tsujioka, S. Arakawa.: Autophagic Cell Death and Cancer. Int J Mol Sci.. 2014.02; 15 3145-3153.

Egawa, M., Mukai, K., and Karasuyama, H.: Basophil-derived IL-4 induces the differentiation of inflammatory monocytes into M2-type macrophages to dampen allergic inflammation. Allergic diseases: from mechanisms to cures.. 2014; 59-62.

Karasuyama H.: Basophils. Global Atlas of Allergy. 2014; 56-57.

U Koura, H Sakaki-Nakatsubo, K Otsubo, K Nomura, K Oshima, O Ohara, T Wada, A Yachie, K Imai, T Morio, T Miyawaki, H Kanegane: Successful treatment of systemic cytomegalovirus infection in severe combined immunodeficiency using allogeneic bone marrow transplantation followed by adoptive immunotherapy. J Investig Allergol Clin Immunol. 2014; 24 (3): 200-202. ( PubMed )

Yohei Matsubara, Tomoki Chiba, Kenichi Kashimada, Tomohiro Morio, Shuji Takada, Shuki Mizutani, Hiroshi Asahara: Transcription activator-like effector nuclease-mediated transduction of exogenous gene into IL2RG locus. Sci Rep. 2014; 4 5043. ( PubMed , DOI )

Satoru Torii, Kohei Sakaki, Miki Otomo, Kyohei Saka, Ken-ichi Yasumoto, Kazuhiro Sogawa: Nucleocytoplasmic shuttling of IPAS by its unique nuclear import and export signals unshared with other HIF-3α splice variants. Journal of Biochemistry. 2013.12; 154 (6): 561-567. ( PubMed , DOI )

Masayuki Nagasawa, Teppei Ohkawa, Akifumi Endo, Noriko Mitsuiki, Toshiaki Ono, Yuki Aoki, Takeshi Isoda, Daisuke Tomizawa, Masatoshi Takagi, Michiko Kajiwara, Tomohiro Morio, Shuki Mizutani: Early coagulation disorder after allogeneic stem cell transplantation is a strong prognostic factor for transplantation-related mortality, and intervention with recombinant human thrombomodulin improves the outcome: a single-center experience. Int. J. Hematol.. 2013.11; 98 (5): 533-542. ( PubMed , DOI )

Mitsuo Ofude, Atsushi Mizokami, Misako Kumaki, Kouji Izumi, Hiroyuki Konaka, Yoshifumi Kadono, Yasuhide Kitagawa, Minkyoung Shin, Jian Zhang, Evan T Keller, Mikio Namiki: Repression of cell proliferation and androgen receptor activity in prostate cancer cells by 2'-hydroxyflavanone. Anticancer Res.. 2013.10; 33 (10): 4453-4461. ( PubMed )

Satoru Kumaki, Yoji Sasahara, Yoshiro Kamachi, Hideki Muramatsu, Tomohiro Morio, Kumiko Goi, Kanji Sugita, Tomonari Urabe, Hidetoshi Takada, Seiji Kojima, Shigeru Tsuchiya, Toshirou Hara: B-cell function after unrelated umbilical cord blood transplantation using a minimal-intensity conditioning regimen in patients with X-SCID. Int. J. Hematol.. 2013.09; 98 (3): 355-360. ( PubMed , DOI )

Sunao Sugita, Manabu Ogawa, Norio Shimizu, Tomohiro Morio, Nobuyuki Ohguro, Kei Nakai, Kazuichi Maruyama, Kenji Nagata, Atsunobu Takeda, Yoshihiko Usui, Koh-Hei Sonoda, Masaru Takeuchi, Manabu Mochizuki: Use of a comprehensive polymerase chain reaction system for diagnosis of ocular infectious diseases. Ophthalmology. 2013.09; 120 (9): 1761-1768. ( PubMed , DOI )

Shizuka Machida, Daisuke Tomizawa, Hiroyuki Tamaichi, Teppei Okawa, Akifumi Endo, Kohsuke Imai, Masayuki Nagasawa, Tomohiro Morio, Shuki Mizutani, Masatoshi Takagi: Successful treatment of diffuse large B-cell lymphoma in a patient with ataxia telangiectasia using rituximab. J. Pediatr. Hematol. Oncol.. 2013.08; 35 (6): 482-485. ( PubMed , DOI )

Minkyoung Shin, Atsushi Mizokami, Jungim Kim, Mitsuo Ofude, Hiroyuki Konaka, Yoshifumi Kadono, Yasuhide Kitagawa, Sotaro Miwa, Misako Kumaki, Evan T Keller, Mikio Namiki: Exogenous SPARC suppresses proliferation and migration of prostate cancer by interacting with integrin β1. Prostate. 2013.08; 73 (11): 1159-1170. ( PubMed , DOI )

Junya Unno, Masatoshi Takagi, Jinhua Piao, Masataka Sugimoto, Fumiko Honda, Daisuke Maeda, Mitsuko Masutani, Tohru Kiyono, Fumiaki Watanabe, Tomohiro Morio, Hirobumi Teraoka, Shuki Mizutani: Artemis-dependent DNA double-strand break formation at stalled replication forks. Cancer Sci.. 2013.06; 104 (6): 703-710. ( PubMed , DOI )

Juhász G, Puertollano R, Shimizu S, Vaccaro MI: Autophagy researchers. Autophagy. 2013.06; 9 (6): 815-8. ( PubMed , DOI )

Ayami Yoshimi, Yoshiro Kamachi, Kosuke Imai, Nobuhiro Watanabe, Hisaya Nakadate, Takashi Kanazawa, Shuichi Ozono, Ryoji Kobayashi, Misa Yoshida, Chie Kobayashi, Asahito Hama, Hideki Muramatsu, Yoji Sasahara, Marcus Jakob, Tomohiro Morio, Stephan Ehl, Atsushi Manabe, Charlotte Niemeyer, Seiji Kojima: Wiskott-Aldrich syndrome presenting with a clinical picture mimicking juvenile myelomonocytic leukaemia. Pediatr Blood Cancer. 2013.05; 60 (5): 836-841. ( PubMed , DOI )

Taizo Wada, Masahiro Muraoka, Tomoko Toma, Tsuyoshi Imai, Tomonari Shigemura, Kazunaga Agematsu, Kohei Haraguchi, Hiroyuki Moriuchi, Tsutomu Oh-Ishi, Toshiyuki Kitoh, Osamu Ohara, Tomohiro Morio, Akihiro Yachie: Rapid detection of intracellular p47phox and p67phox by flow cytometry; useful screening tests for chronic granulomatous disease. J. Clin. Immunol.. 2013.05; 33 (4): 857-864. ( PubMed , DOI )

Takeshi Isoda, Noriko Mitsuiki, Teppei Ohkawa, Setsuko Kaneko, Akifumi Endo, Toshiaki Ono, Yuki Aoki, Daisuke Tomizawa, Michiko Kajiwara, Satoshi Araki, Masayuki Nagasawa, Tomohiro Morio, Masatoshi Takagi, Shuki Mizutani: Irreversible leukoencephalopathy after reduced-intensity stem cell transplantation in a dyskeratosis congenita patient with TINF2 mutation. J. Pediatr. Hematol. Oncol.. 2013.05; 35 (4): e178-e182. ( PubMed , DOI )

Chikako Kamae, Noriko Nakagawa, Hiroki Sato, Kenichi Honma, Noriko Mitsuiki, Osamu Ohara, Hirokazu Kanegane, Srdjan Pasic, Qiang Pan-Hammarström, Menno C van Zelm, Tomohiro Morio, Kohsuke Imai, Shigeaki Nonoyama: Common variable immunodeficiency classification by quantifying T-cell receptor and immunoglobulin κ-deleting recombination excision circles. J. Allergy Clin. Immunol.. 2013.05; 131 (5): 1437-40.e5. ( PubMed , DOI )

T. Mizushima, S. Arakawa, Y. Sanada, I. Yoshino, D. Miyazaki, H. Urushima, Y. Tsujimoto, T. Ito, S.Shimizu : Inhibition of epithelial cell death by Bcl-2 improved chronic colitis in IL10 KO mice American J Pathology. 2013.04; 183 1936-1944.

Tae-Yoon Park, Seung-Hyung Kim, Yoon-Chul Shin, Nae-Hyun Lee, Rae-Kyung Christina Lee, Jae-Hyuck Shim, Laurie H Glimcher, Inhee Mook-Jung, Eunji Cheong, Won-Ki Kim, Fumiko Honda, Tomohiro Morio, Jong-Soon Lim, Sang-Kyou Lee: Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin. J Control Release. 2013.03; 166 (3): 307-315. ( PubMed , DOI )

Chie Miyabe, Yoshishige Miyabe, Noriko N Miura, Kei Takahashi, Yuya Terashima, Etsuko Toda, Fumiko Honda, Tomohiro Morio, Naoko Yamagata, Naohito Ohno, Koichi Shudo, Jun-ichi Suzuki, Mitsuaki Isobe, Kouji Matsushima, Ryoji Tsuboi, Nobuyuki Miyasaka, Toshihiro Nanki: Am80, a retinoic acid receptor agonist, ameliorates murine vasculitis through the suppression of neutrophil migration and activation. Arthritis Rheum.. 2013.02; 65 (2): 503-512. ( PubMed , DOI )

Masaki Shimizu, Hirokazu Kanegane, Taizo Wada, Yaeko Motoyoshi, Tomohiro Morio, Fabio Candotti, Akihiro Yachie: Aberrant glycosylation of IgA in Wiskott-Aldrich syndrome and X-linked thrombocytopenia. J. Allergy Clin. Immunol.. 2013.02; 131 (2): 587-90.e1. ( PubMed , DOI )

Yukako Kawasaki, Hidemi Toyoda, Shoichiro Otsuki, Tadashi Iwasa, Shotaro Iwamoto, Eiichi Azuma, Naomi Itoh-Habe, Hideo Wada, Yoshihiro Fujimura, Tomohiro Morio, Kohsuke Imai, Noriko Mitsuiki, Osamu Ohara, Yoshihiro Komada: A novel Wiskott-Aldrich syndrome protein mutation in an infant with thrombotic thrombocytopenic purpura. Eur. J. Haematol.. 2013.02; 90 (2): 164-168. ( PubMed , DOI )

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Hida S, Yamasaki S, Sakamoto Y, Takamoto M, Obata K, Takai T, Karasuyama H, Sugane K, Saito T, Taki S: Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils. Nat Immunol. 2009.02; 10 (2): 214-222. ( PubMed , DOI )

Khodoun M, Strait R, Orekov T, Hogan S, Karasuyama H, Herbert DR, Kohl J, Finkelman FD: Peanuts can contribute to anaphylactic shock by activating complement. J Allergy Clin Immunol. 2009.02; 123 (2): 342-351. ( PubMed , DOI )

M Honda, M Takagi, L Chessa, T Morio, S Mizuatni: Rapid diagnosis of ataxia-telangiectasia by flow cytometric monitoring of DNA damage-dependent ATM phosphorylation. Leukemia. 2009.02; 23 (2): 409-414. ( PubMed , DOI )

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Karasuyama H, Mukai K, Tsujimura Y, Obata K: Newly discovered roles for basophils: a neglected minority gains new respect. Nat Rev Immunol. 2009.01; 9 (1): 9-13. ( PubMed , DOI )

Yoshikawa S, Kawano Y, Minegishi Y, Karasuyama H: The skewed heavy-chain repertoire in peritoneal B-1 cells is predetermined by the selection via pre-B cell receptor during B cell ontogeny in the fetal liver. Int Immunol. 2009.01; 21 (1): 43-52. ( PubMed , DOI )

Toshihiro Nanki, Kazuki Takada, Yukiko Komano, Tomohiro Morio, Hirokazu Kanegane, Atsuo Nakajima, Peter E Lipsky, Nobuyuki Miyasaka: Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis. Arthritis Res. Ther.. 2009; 11 (5): R149. ( PubMed , DOI )

Yuri Futagami, Sunao Sugita, Takuro Fujimaki, Toshiyuki Yokoyama, Tomohiro Morio, Manabu Mochizuki: Bilateral anterior granulomatous keratouveitis with sunset glow fundus in a patient with autoimmune polyglandular syndrome. Ocul. Immunol. Inflamm.. 2009; 17 (2): 88-90. ( PubMed , DOI )

Takada T, Shitara H, Matsuoka K, Kojima E, Ishii R, Kikkawa Y, Taya C, Karasuyama H, Kohno K, Yonekawa H: A novel hairless mouse model on an atopic dermatitis-prone genetic background generated by receptor-mediated transgenesis. Transgenic Res. 2008.12; 17 (6): 1155-1162. ( PubMed , DOI )

Watanabe M, Satoh T, Yamamoto Y, Kanai Y, Karasuyama H, Yokozeki H: Overproduction of IgE induces macrophage-derived chemokine (CCL22) secretion from basophils. J Immunol. 2008.10; 181 (8): 5653-5659. ( PubMed )

Minegishi Y, Karasuyama H: Genetic origins of hyper-IgE syndrome. Curr Allergy Asthma Rep. 2008.09; 8 (5): 386-391. ( PubMed )

S Sugita, N Shimizu, K Watanabe, M Mizukami, T Morio, Y Sugamoto, M Mochizuki: Use of multiplex PCR and real-time PCR to detect human herpes virus genome in ocular fluids of patients with uveitis. Br J Ophthalmol. 2008.07; 92 (7): 928-932. ( PubMed , DOI )

Inagaki R, Tagawa K, Qi ML, Enokido Y, Ito H, Tamura T, Shimizu S, Oyanagi K, Arai N, Kanazawa I, Wanker EE, Okazawa H: Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease. Eur. J. Neurosci. 2008.07; 28 (1): 30-40. ( PubMed , DOI )

Koichi Suzuki, Koji Tsugawa, Eishin Oki, Tomohiro Morio, Etsuro Ito, Hiroshi Tanaka: Vesical varices and telangiectasias in a patient with ataxia telangiectasia. Pediatr. Nephrol.. 2008.06; 23 (6): 1005-1008. ( PubMed , DOI )

Tsujimura Y, Obata K, Mukai K, Shindou H, Yoshida M, Nishikado H, Kawano Y, Minegishi Y, Shimizu T, Karasuyama H: Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity. 2008.04; 28 (4): 581-589. ( PubMed , DOI )

Yasuda T, Sanjo H, Pages G, Kawano Y, Karasuyama H, Pouyssegur J, Ogata M, Kurosaki T: Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity. 2008.04; 28 (4): 499-508. ( PubMed , DOI )

S Kido, S Sugita, S Horie, M Miyanaga, K Miyata, N Shimizu, T Morio, M Mochizuki: Association of varicella zoster virus load in the aqueous humor with clinical manifestations of anterior uveitis in herpes zoster ophthalmicus and zoster sine herpete. Br J Ophthalmol. 2008.04; 92 (4): 505-508. ( PubMed , DOI )

Min Kyoung Shin, Mi-Kyoung Kim, Yoe-Sik Bae, Inho Jo, Seung-Jin Lee, Chong-Pyoung Chung, Yoon-Jeong Park, Do Sik Min: A novel collagen-binding peptide promotes osteogenic differentiation via Ca2+/calmodulin-dependent protein kinase II/ERK/AP-1 signaling pathway in human bone marrow-derived mesenchymal stem cells. Cell. Signal.. 2008.04; 20 (4): 613-624. ( PubMed , DOI )

Changjong Moon, Heechul Kim, Seungjoon Kim, Yongduk Lee, Min Kyoung Shin, Do Sik Min, Taekyun Shin: Transient expression of phospholipase D1 during heart development in rats. J. Vet. Med. Sci.. 2008.04; 70 (4): 411-413. ( PubMed )

Masahiro Shinohara, Takako Koga, Kazuo Okamoto, Shinya Sakaguchi, Kimiko Arai, Hisataka Yasuda, Toshiyuki Takai, Tatsuhiko Kodama, Tomohiro Morio, Raif S Geha, Daisuke Kitamura, Tomohiro Kurosaki, Wilfried Ellmeier, Hiroshi Takayanagi: Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell. 2008.03; 132 (5): 794-806. ( PubMed , DOI )

Kajitani K, Fujihashi M, Kobayashi Y, Shimizu S, Tsujimoto Y, Miki K: Crystal structure of human cyclophilin D in complex with its inhibitor, cyclosporin A at 0.96-A resolution. Proteins. 2008.03; 70 (4): 1635-1639. ( PubMed , DOI )

Daiichiro Hasegawa, Masako Fukushima, Yuki Hosokawa, Hiroki Takeda, Keiichiro Kawasaki, Tomoyuki Mizukami, Hiroyuki Nunoi, Hiroshi Ochiai, Tomohiro Morio, Yoshiyuki Kosaka: Successful treatment of chronic granulomatous disease with fludarabine-based reduced-intensity conditioning and unrelated bone marrow transplantation. Int. J. Hematol.. 2008.01; 87 (1): 88-90. ( PubMed , DOI )

Sayaka Yamamoto, Sunao Sugita, Yoshiharu Sugamoto, Norio Shimizu, Tomohiro Morio, Manabu Mochizuki: Quantitative PCR for the detection of genomic DNA of Epstein-Barr virus in ocular fluids of patients with uveitis. Jpn. J. Ophthalmol.. 2008; 52 (6): 463-467. ( PubMed , DOI )

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Suzuki C, Isaka Y, Shimizu S, Tsujimoto Y, Takabatake Y, Ito T, Takahara S, Imai E: Bcl-2 protects tubular epithelial cells from ischemia reperfusion injury by inhibiting apoptosis. Cell Transplant. 2008; 17 (1-2): 223-229. ( PubMed )

Tomohiro Morio, Hyeyoung Kim: Ku, Artemis, and ataxia-telangiectasia-mutated: signalling networks in DNA damage. Int. J. Biochem. Cell Biol.. 2008; 40 (4): 598-603. ( PubMed , DOI )

Minegishi Y, Karasuyama H: Hyperimmunoglobulin E syndrome and tyrosine kinase 2 deficiency. Curr Opin Allergy Clin Immunol. 2007.12; 7 (6): 506-509. ( PubMed , DOI )

Kojima T, Obata K, Mukai K, Sato S, Takai T, Minegishi Y, Karasuyama H: Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner. J Immunol. 2007.11; 179 (10): 7093-7100. ( PubMed )

Morio T: Strategy to Combat Opportunistic Infections after Umbilical Cord Blood Transplantation (UCBT) - Monitoring of Multiple Pathogens with a Novel Multiplex PCR System and Infusion of Ex-vivo Expanded CD4 T-Cells (CD4-DLI). Biol Blood Marrow Tr. . 2007.11; 13 (11): 1400-1401.

Sunao Sugita, Norio Shimizu, Tastushi Kawaguchi, Nobuaki Akao, Tomohiro Morio, Manabu Mochizuki: Identification of human herpesvirus 6 in a patient with severe unilateral panuveitis. Arch. Ophthalmol.. 2007.10; 125 (10): 1426-1427. ( PubMed , DOI )

S Horibe, M Takagi, J Unno, M Nagasawa, T Morio, A Arai, O Miura, M Ohta, M Kitagawa, S Mizutani: DNA damage check points prevent leukemic transformation in myelodysplastic syndrome. Leukemia. 2007.10; 21 (10): 2195-2198. ( PubMed , DOI )

Seungjoon Kim, Heechul Kim, Yongduk Lee, Jin Won Hyun, Young Ho Lee, Min Kyoung Shin, Do Sik Min, Taekyun Shin: The expression and cellular localization of phospholipase D isozymes in the developing mouse testis. J. Vet. Sci.. 2007.09; 8 (3): 209-212. ( PubMed )

Obata K, Mukai K, Tsujimura Y, Ishiwata K, Kawano Y, Minegishi Y, Watanabe N, Karasuyama H: Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood. 2007.08; 110 (3): 913-920. ( PubMed , DOI )

Minegishi Y, Saito M, Tsuchiya S, Tsuge I, Takada H, Hara T, Kawamura N, Ariga T, Pasic S, Stojkovic O, Metin A, Karasuyama H: Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature. 2007.08; 448 (7157): 1058-1062. ( PubMed , DOI )

Do Sik Min, Jeong-Sun Choi, Ha-Young Kim, Min Kyoung Shin, Mi Kyoung Kim, Mun-Yong Lee: Ischemic preconditioning upregulates expression of phospholipase D2 in the rat hippocampus. Acta Neuropathol.. 2007.08; 114 (2): 157-162. ( PubMed , DOI )

H Okamoto, C Arii, F Shibata, T Toma, T Wada, M Inoue, Y Tone, Y Kasahara, S Koizumi, Y Kamachi, Y Ishida, J Inagaki, M Kato, T Morio, A Yachie: Clonotypic analysis of T cell reconstitution after haematopoietic stem cell transplantation (HSCT) in patients with severe combined immunodeficiency. Clin. Exp. Immunol.. 2007.06; 148 (3): 450-460. ( PubMed , DOI )

C Tono, Y Takahashi, K Terui, S Sasaki, T Kamio, S Tandai, T Sato, K Kudo, T Toki, N Tachibana, T Yoshioka, T Nakahata, T Morio, R Nishikomori, E Ito: Correction of immunodeficiency associated with NEMO mutation by umbilical cord blood transplantation using a reduced-intensity conditioning regimen. Bone Marrow Transplant.. 2007.06; 39 (12): 801-804. ( PubMed , DOI )

Mizuta T, Shimizu S, Matsuoka Y, Nakagawa T, Tsujimoto Y: A Bax/Bak-independent mechanism of cytochrome c release. J Biol Chem. 2007.06; 282 (22): 16623-16630. ( PubMed , DOI )

Tsujimoto Y, Shimizu S: Role of the mitochondrial membrane permeability transition in cell death. Apoptosis. 2007.05; 12 (5): 835-840. ( PubMed , DOI )

Yakata Kaya, Hiroaki Yoko, Ishibashi Kenichi, Sohara Eisei, Sasaki Sei, Mitsuoka Kaoru, Fujiyoshi Yoshinori: Aquaporin-11 containing a divergent NPA motif has normal water channel activity. Biochim Biophys Acta. 2007.03; 1768 (3): 688-693. ( PubMed , DOI )

Kumiko Ohnuma-Ishikawa, Tomohiro Morio, Takayuki Yamada, Yuji Sugawara, Makoto Ono, Masayuki Nagasawa, Akio Yasuda, Chikao Morimoto, Kei Ohnuma, Nam H Dang, Hajime Hosoi, Eric Verdin, Shuki Mizutani: Knockdown of XAB2 enhances all-trans retinoic acid-induced cellular differentiation in all-trans retinoic acid-sensitive and -resistant cancer cells. Cancer Res.. 2007.02; 67 (3): 1019-1029. ( PubMed , DOI )

Heechul Kim, Jeeyoung Lee, Seungjoon Kim, Min Kyoung Shin, Do Sik Min, Taekyun Shin: Differential expression of phospholipases D1 and D2 in mouse tissues. Cell Biol. Int.. 2007.02;

Satoru Watanabe, Kazuo Terashima, Shinrai Ohta, Shigeo Horibata, Misako Yajima, Yoko Shiozawa, M Zahidunnabi Dewan, Zhong Yu, Mamoru Ito, Tomohiro Morio, Norio Shimizu, Mitsuo Honda, Naoki Yamamoto: Hematopoietic stem cell-engrafted NOD/SCID/IL2Rgamma null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses. Blood. 2007.01; 109 (1): 212-218. ( PubMed , DOI )

Ochiai K, Katoh Y, Ikura T, Hoshikawa Y, Noda T, Karasuyama H, Tashiro S, Muto A, Igarashi K: Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells. J Biol Chem. 2006.12; 281 (50): 38226-38234. ( PubMed , DOI )

Jong Hwa Lee, Kyung Hwan Kim, Tomohiro Morio, Hyeyoung Kim: Ataxia-telangiectasia-mutated-dependent activation of Ku in human fibroblasts exposed to hydrogen peroxide. Ann. N. Y. Acad. Sci.. 2006.12; 1091 76-82. ( PubMed , DOI )

Minegishi Y, Saito M, Morio T, Watanabe K, Agematsu K, Tsuchiya S, Takada H, Hara T, Kawamura N, Ariga T, Kaneko H, Kondo N, Tsuge I, Yachie A, Sakiyama Y, Iwata T, Bessho F, Ohishi T, Joh K, Imai K, Kogawa K, Shinohara M, Fujieda M, Wakiguchi H, Pasic S, Abinun M, Ochs HD, Renner ED, Jansson A, Belohradsky BH, Metin A, Shimizu N, Mizutani S, Miyawaki T, Nonoyama S, Karasuyama H: Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity. 2006.11; 25 (5): 745-755. ( PubMed , DOI )

Shinichiro Y Koga, Satoru Kumaki, Ryo Ichinohasama, Mitsutoshi Munakata, Kazuhiro Haginoya, Yoshiyuki Ohashi, Yoshiko Tanaka, Osamu Sakamoto, Masayoshi Minegishi, Tomohiro Morio, Kazuie Iinuma, Shigeru Tsuchiya: The first infant case with hepatosplenic gammadelta T-cell lymphoma after acute disseminated encephalomyelitis (ADEM)-like exacerbation. J. Pediatr. Hematol. Oncol.. 2006.11; 28 (11): 741-745. ( PubMed , DOI )

Ryoji Kobayashi, Tadashi Ariga, Shigeaki Nonoyama, Hirokazu Kanegane, Shigeru Tsuchiya, Tomohiro Morio, Hiromasa Yabe, Yoshihisa Nagatoshi, Keisei Kawa, Ken Tabuchi, Masahiro Tsuchida, Toshio Miyawaki, Shunichi Kato: Outcome in patients with Wiskott-Aldrich syndrome following stem cell transplantation: an analysis of 57 patients in Japan. Br. J. Haematol.. 2006.11; 135 (3): 362-366. ( PubMed , DOI )

Simamura E, Hirai K, Shimada H, Koyama J, Niwa Y, Shimizu S: Furanonaphthoquinones cause apoptosis of cancer cells by inducing the production of reactive oxygen species by the mitochondrial voltage-dependent anion channel. Cancer Biol Ther. 2006.11; 5 (11): 1523-1529. ( PubMed )

Yamamoto M, Hayashi K, Nojima T, Matsuzaki Y, Kawano Y, Karasuyama H, Goitsuka R, Kitamura D: BASH-novel PKC-Raf-1 pathway of pre-BCR signaling induces kappa gene rearrangement. Blood. 2006.10; 108 (8): 2703-2711. ( PubMed , DOI )

Kawano Y, Yoshikawa S, Minegishi Y, Karasuyama H: Pre-B cell receptor assesses the quality of IgH chains and tunes the pre-B cell repertoire by delivering differential signals. J Immunol. 2006.08; 177 (4): 2242-2249. ( PubMed )

Satoru Torii, Takuya Yamamoto, Yoshiki Tsuchiya, Eisuke Nishida: ERK MAP kinase in G cell cycle progression and cancer. Cancer Science. 2006.08; 97 (8): 697-702. ( PubMed , DOI )

Ito K, Oji Y, Tatsumi N, Shimizu S, Kanai Y, Nakazawa T, Asada M, Jomgeow T, Aoyagi S, Nakano Y, Tamaki H, Sakaguchi N, Shirakata T, Nishida S, Kawakami M, Tsuboi A, Oka Y, Tsujimoto Y, Sugiyama H: Antiapoptotic function of 17AA(+)WT1 (Wilms' tumor gene) isoforms on the intrinsic apoptosis pathway. Oncogene. 2006.07; 25 (30): 4217-4229. ( PubMed , DOI )

Kubota T, Mukai K, Minegishi Y, Karasuyama H: Different stabilities of the structurally related receptors for IgE and IgG on the cell surface are determined by length of the stalk region in their alpha-chains. J Immunol. 2006.06; 176 (11): 7008-7014. ( PubMed )

Masahiko Kato, Hirokazu Kimura, Mitsuru Seki, Akira Shimada, Yasuhide Hayashi, Tomohiro Morio, Satoru Kumaki, Yasushi Ishida, Yoshiro Kamachi, Akihiro Yachie: Omenn syndrome--review of several phenotypes of Omenn syndrome and RAG1/RAG2 mutations in Japan. Allergol Int. 2006.06; 55 (2): 115-119. ( PubMed , DOI )

Masayuki Nagasawa, Takeshi Isoda, Sukeyuki Itoh, Michiko Kajiwara, Tomohiro Morio, Norio Shimizu, Kazuyuki Ogawa, Kinya Nagata, Masataka Nakamura, Shuki Mizutani: Analysis of serum granulysin in patients with hematopoietic stem-cell transplantation: its usefulness as a marker of graft-versus-host reaction. Am. J. Hematol.. 2006.05; 81 (5): 340-348. ( PubMed , DOI )

Y Tsuji, K Imai, M Kajiwara, Y Aoki, T Isoda, D Tomizawa, M Imai, S Ito, H Maeda, Y Minegishi, H Ohkawa, J Yata, N Sasaki, K Kogawa, M Nagasawa, T Morio, S Nonoyama, S Mizutani: Hematopoietic stem cell transplantation for 30 patients with primary immunodeficiency diseases: 20 years experience of a single team. Bone Marrow Transplant.. 2006.03; 37 (5): 469-477. ( PubMed , DOI )

Kohsuke Imai, Mitsunobu Shimadzu, Takeo Kubota, Tomohiro Morio, Takeshi Matsunaga, Young-Dong Park, Akira Yoshioka, Shigeaki Nonoyama: Female hyper IgM syndrome type 1 with a chromosomal translocation disrupting CD40LG. Biochim. Biophys. Acta. 2006.03; 1762 (3): 335-340. ( PubMed , DOI )

Jae-Ho Chang, Soo-Ki Kim, In-Hong Choi, Sang-Kyou Lee, Tomohiro Morio, Eun-Ju Chang: Apoptosis of macrophages induced by Trichomonas vaginalis through the phosphorylation of p38 mitogen-activated protein kinase that locates at downstream of mitochondria-dependent caspase activation. Int. J. Biochem. Cell Biol.. 2006; 38 (4): 638-647. ( PubMed , DOI )

Tsujimoto Y, Nakagawa T, Shimizu S: Mitochondrial membrane permeability transition and cell death. Biochim Biophys Acta. 2006; 1757 (9-10): 1297-1300. ( PubMed , DOI )

Daisuke Tomizawa, Yuki Aoki, Masayuki Nagasawa, Tomohiro Morio, Michiko Kajiwara, Teruaki Sekine, Norio Shimizu, Masahiko Kato, Akihiro Yachie, Shuki Mizutani: Novel adopted immunotherapy for mixed chimerism after unrelated cord blood transplantation in Omenn syndrome. Eur. J. Haematol.. 2005.11; 75 (5): 441-444. ( PubMed , DOI )

Tsujimoto Y, Shimizu S: Another way to die: autophagic programmed cell death. Cell Death Differ. 2005.11; 12 Suppl 2 1528-1534. ( PubMed , DOI )

Motohiko Okano, Keisei Kawa, Hiroshi Kimura, Akihiro Yachie, Hiroshi Wakiguchi, Akihiko Maeda, Shosuke Imai, Shouichi Ohga, Hirokazu Kanegane, Shigeru Tsuchiya, Tomohiro Morio, Masaaki Mori, Shumpei Yokota, Shinsaku Imashuku: Proposed guidelines for diagnosing chronic active Epstein-Barr virus infection. Am. J. Hematol.. 2005.09; 80 (1): 64-69. ( PubMed , DOI )

Yoichiro Tsuji, Sukeyuki Ito, Takeshi Isoda, Michiko Kajiwara, Masayuki Nagasawa, Tomohiro Morio, Shuki Mizutani: Successful nonmyeloablative cord blood transplantation for an infant with malignant infantile osteopetrosis. J. Pediatr. Hematol. Oncol.. 2005.09; 27 (9): 495-498. ( PubMed )

Ji Hoon Yu, Joo Weon Lim, Kyung Hwan Kim, Tomohiro Morio, Hyeyoung Kim: NADPH oxidase and apoptosis in cerulein-stimulated pancreatic acinar AR42J cells. Free Radic. Biol. Med.. 2005.09; 39 (5): 590-602. ( PubMed , DOI )

Mukai K, Matsuoka K, Taya C, Suzuki H, Yokozeki H, Nishioka K, Hirokawa K, Etori M, Yamashita M, Kubota T, Minegishi Y, Yonekawa H, Karasuyama H: Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity. 2005.08; 23 (2): 191-202. ( PubMed , DOI )

Takahashi N, Kobayashi S, Kajino S, Imai K, Tomoda K, Shimizu S, Okamoto T: Inhibition of the 53BP2S-mediated apoptosis by nuclear factor kappaB and Bcl-2 family proteins. Genes to cells : devoted to molecular & cellular mechanisms. 2005.08; 10 (8): 803-11. ( PubMed , DOI )

Elinder F, Akanda N, Tofighi R, Shimizu S, Tsujimoto Y, Orrenius S, Ceccatelli S: Opening of plasma membrane voltage-dependent anion channels (VDAC) precedes caspase activation in neuronal apoptosis induced by toxic stimuli. Cell Death Differ. 2005.08; 12 (8): 1134-1140. ( PubMed , DOI )

Kawano Y, Yoshikawa S, Minegishi Y, Karasuyama H: Selection of stereotyped VH81X-{micro}H chains via pre-B cell receptor early in ontogeny and their conservation in adults by marginal zone B cells. Int Immunol. 2005.07; 17 (7): 857-867. ( PubMed , DOI )

Chen C, Shimizu S, Tsujimoto Y, Motoyama N: Chk2 regulates transcription-independent p53-mediated apoptosis in response to DNA damage. Biochem Biophys Res Commun. 2005.07; 333 (2): 427-431. ( PubMed , DOI )

Kunio Kondoh, Satoru Torii, Eisuke Nishida: Control of MAP kinase signaling to the nucleus. Chromosoma. 2005.07; 114 (2): 86-91. ( PubMed , DOI )

Jimi E, Phillips RJ, Rincon M, Voll R, Karasuyama H, Flavell R, Ghosh S: Activation of NF-kappaB promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells. Int Immunol. 2005.06; 17 (6): 815-825. ( PubMed , DOI )

Kohsuke Imai, Yi Zhu, Patrick Revy, Tomohiro Morio, Shuki Mizutani, Alain Fischer, Shigeaki Nonoyama, Anne Durandy: Analysis of class switch recombination and somatic hypermutation in patients affected with autosomal dominant hyper-IgM syndrome type 2. Clin. Immunol.. 2005.06; 115 (3): 277-285. ( PubMed , DOI )

Omata N, Ohshima Y, Yasutomi M, Yamada A, Karasuyama H, Mayumi M: Ovalbumin-specific IgE modulates ovalbumin-specific T-cell response after repetitive oral antigen administration. J Allergy Clin Immunol. 2005.04; 115 (4): 822-827. ( PubMed , DOI )

Toyama-Sorimachi N, Omatsu Y, Onoda A, Tsujimura Y, Iyoda T, Kikuchi-Maki A, Sorimachi H, Dohi T, Taki S, Inaba K, Karasuyama H: Inhibitory NK receptor Ly49Q is expressed on subsets of dendritic cells in a cellular maturation- and cytokine stimulation-dependent manner. J Immunol. 2005.04; 174 (8): 4621-4629. ( PubMed )

Zhang L, Shimizu S, Tsujimoto Y: Two distinct Fas-activated signaling pathways revealed by an antitumor drug D609. Oncogene. 2005.04; 24 (18): 2954-2962. ( PubMed , DOI )

Nakagawa T, Shimizu S, Watanabe T, Yamaguchi O, Otsu K, Yamagata H, Inohara H, Kubo T, Tsujimoto Y: Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature. 2005.03; 434 (7033): 652-658. ( PubMed , DOI )

Shinohara H, Inoue A, Toyama-Sorimachi N, Nagai Y, Yasuda T, Suzuki H, Horai R, Iwakura Y, Yamamoto T, Karasuyama H, Miyake K, Yamanashi Y: Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling. J Exp Med. 2005.02; 201 (3): 333-339. ( PubMed , DOI )

Ling Chen, Tomohiro Morio, Yoshiyuki Minegishi, Shin-Ichiro Nakada, Masayuki Nagasawa, Kenshi Komatsu, Luciana Chessa, Anna Villa, Daniele Lecis, Domenico Delia, Shuki Mizutani: Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage. Cancer Sci.. 2005.02; 96 (2): 134-141. ( PubMed , DOI )

Masayuki Nagasawa, Yi Zhu, Takeshi Isoda, Daisuke Tomizawa, Sukeyuki Itoh, Michiko Kajiwara, Tomohiro Morio, Shigeaki Nonoyama, Norio Shimizu, Shuki Mizutani: Analysis of serum soluble CD40 ligand (sCD40L) in the patients undergoing allogeneic stem cell transplantation: platelet is a major source of serum sCD40L. Eur. J. Haematol.. 2005.01; 74 (1): 54-60. ( PubMed , DOI )

Ono M, Sawa Y, Ryugo M, Alechine AN, Shimizu S, Sugioka R, Tsujimoto Y, Matsuda H: BH4 peptide derivative from Bcl-xL attenuates ischemia/reperfusion injury thorough anti-apoptotic mechanism in rat hearts. Eur J Cardiothorac Surg. 2005.01; 27 (1): 117-121. ( PubMed , DOI )

Yoshikazu Ohtsuka, Toshiaki Shimizu, Kyoko Nishizawa, Risako Ohtaki, Tomonosuke Someya, Atsuko Noguchi, Naoto Shimura, Hyoiru Kim, Harunori Sugimoto, Hiroo Fujita, Tomohiro Morio, Yuichiro Yamashiro: Successful engraftment and decrease of cytomegalovirus load after cord blood stem cell transplantation in a patient with DiGeorge syndrome. Eur. J. Pediatr.. 2004.12; 163 (12): 747-748. ( PubMed , DOI )

Sugioka R, Shimizu S, Tsujimoto Y: Fzo1, a protein involved in mitochondrial fusion, inhibits apoptosis. J Biol Chem. 2004.12; 279 (50): 52726-52734. ( PubMed , DOI )

Shimizu S, Kanaseki T, Mizushima N, Mizuta T, Arakawa-Kobayashi S, Thompson CB, Tsujimoto Y: Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol. 2004.12; 6 (12): 1221-1228. ( PubMed , DOI )

Satoru Torii, Kei Nakayama, Takuya Yamamoto, Eisuke Nishida: Regulatory mechanisms and function of ERK MAP kinases. Journal of Biochemistry. 2004.11; 136 (5): 557-561. ( PubMed , DOI )

Jae-Ho Chang, Yong-Suk Ryang, Tomohiro Morio, Sang-Kyou Lee, Eun-Ju Chang: Trichomonas vaginalis inhibits proinflammatory cytokine production in macrophages by suppressing NF-kappaB activation. Mol. Cells. 2004.10; 18 (2): 177-185. ( PubMed )

Wook-Jin Chae, Heung-Kyu Lee, Jin-Hwan Han, Sang-Won Vincent Kim, Alfred L M Bothwell, Tomohiro Morio, Sang-Kyou Lee: Qualitatively differential regulation of T cell activation and apoptosis by T cell receptor zeta chain ITAMs and their tyrosine residues. Int. Immunol.. 2004.09; 16 (9): 1225-1236. ( PubMed , DOI )

Taguchi T, Kiyokawa N, Takenouch H, Matsui J, Tang WR, Nakajima H, Suzuki K, Shiozawa Y, Saito M, Katagiri YU, Takahashi T, Karasuyama H, Matsuo Y, Okita H, Fujimoto J: Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells. Immunology. 2004.08; 112 (4): 575-582. ( PubMed , DOI )

Zhang L, Shimizu S, Sakamaki K, Yonehara S, Tsujimoto Y: A caspase-8-independent signaling pathway activated by Fas ligation leads to exposure of the Bak N terminus. J Biol Chem. 2004.08; 279 (32): 33865-33874. ( PubMed , DOI )

Satoru Torii, Morioh Kusakabe, Takuya Yamamoto, Momoko Maekawa, Eisuke Nishida: Sef is a spatial regulator for Ras/MAP kinase signaling. Developmental Cell. 2004.07; 7 (1): 33-44. ( PubMed , DOI )

Daisuke Tomizawa, Kohsuke Imai, Sukeyuki Ito, Michiko Kajiwara, Yoshiyuki Minegishi, Masayuki Nagasawa, Tomohiro Morio, Shigeaki Nonoyama, Shuki Mizutani: Allogeneic hematopoietic stem cell transplantation for seven children with X-linked hyper-IgM syndrome: a single center experience. Am. J. Hematol.. 2004.05; 76 (1): 33-39. ( PubMed , DOI )

Hiroshi Hanafusa, Satoru Torii, Takayuki Yasunaga, Kunihiro Matsumoto, Eisuke Nishida: Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty. Journal of Biological Chemistry. 2004.05; 279 (22): 22992-22995. ( PubMed , DOI )

Kiyokawa N, Sekino T, Matsui T, Takenouchi H, Mimori K, Tang WR, Matsui J, Taguchi T, Katagiri YU, Okita H, Matsuo Y, Karasuyama H, Fujimoto J: Diagnostic importance of CD179a/b as markers of precursor B-cell lymphoblastic lymphoma. Mod Pathol. 2004.04; 17 (4): 423-429. ( PubMed , DOI )

Tsuruta F, Sunayama J, Mori Y, Hattori S, Shimizu S, Tsujimoto Y, Yoshioka K, Masuyama N, Gotoh Y: JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins. EMBO J. 2004.04; 23 (8): 1889-1899. ( PubMed , DOI )

Masayuki Nagasawa, Daisuke Tomizawa, Youichirou Tsuji, Michiko Kajiwara, Tomohiro Morio, Shigeaki Nonoyama, Minoru Asada, Shuki Mizutani: Pancytopenia presenting with monosomy 7 which disappeared after immunosuppressive therapy. Leuk. Res.. 2004.03; 28 (3): 315-319. ( PubMed )

Masayuki Nagasawa, Sukeyuki Itoh, Yasuyuki Sawada, Tomohiro Morio, Shigeaki Nonoyama, Shuki Mizutani: Coagulopathy in a patient with X-linked hyper-IgM syndrome who developed Kaposi's sarcoma. Am. J. Hematol.. 2004.02; 75 (2): 116-117. ( PubMed , DOI )

Noriko Shimasaki, Tetsuya Mori, Hiroyuki Shimada, Mayumi Sugita, Masataka Higuchi, Makio Mukai, Tomohiro Morio, Shinichiro Okamoto: Epstein-Barr virus-associated posttransplant lymphoproliferative disorder after a cord blood stem cell transplantation presenting with pulmonary nodules. J. Pediatr. Hematol. Oncol.. 2004.02; 26 (2): 124-127. ( PubMed )

Maezawa Y, Nakajima H, Seto Y, Suto A, Kumano K, Kubo S, Karasuyama H, Saito Y, Iwamoto I: IgE-dependent enhancement of Th2 cell-mediated allergic inflammation in the airways. Clin Exp Immunol. 2004.01; 135 (1): 12-18. ( PubMed )

Toyama-Sorimachi N, Tsujimura Y, Maruya M, Onoda A, Kubota T, Koyasu S, Inaba K, Karasuyama H: Ly49Q, a member of the Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture. Proc Natl Acad Sci U S A. 2004.01; 101 (4): 1016-1021. ( PubMed , DOI )

Kohsuke Imai, Tomohiro Morio, Yi Zhu, Yinzhu Jin, Sukeyuki Itoh, Michiko Kajiwara, Jun-Ichi Yata, Shuki Mizutani, Hans D Ochs, Shigeaki Nonoyama: Clinical course of patients with WASP gene mutations. Blood. 2004.01; 103 (2): 456-464. ( PubMed , DOI )

Minami J, Eishi Y, Ishige Y, Kobayashi I, Ishige I, Kobayashi D, Ando N, Uchida K, Ikeda S, Sorimachi N, Karasuyama H, Takemura T, Takizawa T, Koike M: Pulmonary granulomas caused experimentally in mice by a recombinant trigger-factor protein of Propionibacterium acnes. J Med Dent Sci. 2003.12; 50 (4): 265-274. ( PubMed )

Sugioka R, Shimizu S, Funatsu T, Tamagawa H, Sawa Y, Kawakami T, Tsujimoto Y: BH4-domain peptide from Bcl-xL exerts anti-apoptotic activity in vivo. Oncogene. 2003.11; 22 (52): 8432-8440. ( PubMed , DOI )

Konishi A, Shimizu S, Hirota J, Takao T, Fan Y, Matsuoka Y, Zhang L, Yoneda Y, Fujii Y, Skoultchi AI, Tsujimoto Y: Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks. Cell. 2003.09; 114 (6): 673-688. ( PubMed )

Ji Yeon Song, Joo Weon Lim, Hyeyoung Kim, Tomohiro Morio, Kyung Hwan Kim: Oxidative stress induces nuclear loss of DNA repair proteins Ku70 and Ku80 and apoptosis in pancreatic acinar AR42J cells. J. Biol. Chem.. 2003.09; 278 (38): 36676-36687. ( PubMed , DOI )

Kawashima I, Yoshida Y, Taya C, Shitara H, Yonekawa H, Karasuyama H, Tada N, Furukawa K, Tai T: Expansion of natural killer cells in mice transgenic for IgM antibody to ganglioside GD2: demonstration of prolonged survival after challenge with syngeneic tumor cells. Int J Oncol. 2003.08; 23 (2): 381-388. ( PubMed )

Terauchi M, Koi H, Hayano C, Toyama-Sorimachi N, Karasuyama H, Yamanashi Y, Aso T, Shirakata M: Placental extravillous cytotrophoblasts persistently express class I major histocompatibility complex molecules after human cytomegalovirus infection. J Virol. 2003.08; 77 (15): 8187-8195. ( PubMed )

Maezawa Y, Nakajima H, Kumano K, Kubo S, Karasuyama H, Iwamoto I: Role of IgE in Th2 cell-mediated allergic airway inflammation. Int Arch Allergy Immunol. 2003.06; 131 Suppl 1 2-6. ( PubMed , DOI )

Yu Zhang, Hiroshi Nagata, Tatsuro Ikeuchi, Hiroyuki Mukai, Michiko K Oyoshi, Ayako Demachi, Tomohiro Morio, Hiroshi Wakiguchi, Nobuhiro Kimura, Norio Shimizu, Kohtaro Yamamoto: Common cytological and cytogenetic features of Epstein-Barr virus (EBV)-positive natural killer (NK) cells and cell lines derived from patients with nasal T/NK-cell lymphomas, chronic active EBV infection and hydroa vacciniforme-like eruptions. Br. J. Haematol.. 2003.06; 121 (5): 805-814. ( PubMed )

Masako Imai, Shuki Mizutani, Tomohiro Morio: Coordinated regulation of the promoter and enhancer regions of human CD23 gene by signal through IL-4R and CD40, and the role of Ku70/80 in the enhancer activity. J. Med. Dent. Sci.. 2003.06; 50 (2): 155-165. ( PubMed )

Michiko K Oyoshi, Hiroshi Nagata, Nobuhiro Kimura, Yu Zhang, Ayako Demachi, Toshiro Hara, Hirokazu Kanegane, Yoshinobu Matsuo, Tomohiro Yamaguchi, Tomohiro Morio, Atsuyoshi Hirano, Norio Shimizu, Kohtaro Yamamoto: Preferential Expansion of Vγ9-JγP/Vδ2-Jδ3 γδ T Cells in Nasal T-Cell Lymphoma and Chronic Active Epstein-Barr Virus Infection. Am. J. Pathol.. 2003.05; 162 (5): 1629-1638. ( PubMed )

Saijo K, Schmedt C, Su IH, Karasuyama H, Lowell CA, Reth M, Adachi T, Patke A, Santana A, Tarakhovsky A: Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol. 2003.03; 4 (3): 274-279. ( PubMed , DOI )

Yi Zhu, Shigeaki Nonoyama, Tomohiro Morio, Masamichi Muramatsu, Tasuku Honjo, Shuki Mizutani: Type two hyper-IgM syndrome caused by mutation in activation-induced cytidine deaminase. J. Med. Dent. Sci.. 2003.03; 50 (1): 41-46. ( PubMed )

Tsuchiya K, Kawano Y, Kojima T, Nagata K, Takao T, Okada M, Shinohara H, Maki K, Toyama-Sorimachi N, Miyasaka N, Watanabe M, Karasuyama H: Molecular cloning and characterization of TPP36 and its isoform TPP32, novel substrates of Abl tyrosine kinase. FEBS Lett. 2003.02; 537 (1-3): 203-209. ( PubMed )

Hiroshi Kimura, Tsuneo Morishima, Hirokazu Kanegane, Shouichi Ohga, Yo Hoshino, Akihiko Maeda, Shosuke Imai, Motohiko Okano, Tomohiro Morio, Shumpei Yokota, Shigeru Tsuchiya, Akihiro Yachie, Shinsaku Imashuku, Keisei Kawa, Hiroshi Wakiguchi, : Prognostic factors for chronic active Epstein-Barr virus infection. J. Infect. Dis.. 2003.02; 187 (4): 527-533. ( PubMed , DOI )

Sato E, Hirahara K, Wada Y, Yoshitomi T, Azuma T, Matsuoka K, Kubo S, Taya C, Yonekawa H, Karasuyama H, Shiraishi A: Chronic inflammation of the skin can be induced in IgE transgenic mice by means of a single challenge of multivalent antigen. J Allergy Clin Immunol. 2003.01; 111 (1): 143-148. ( PubMed )

Kubo S, Nakayama T, Matsuoka K, Yonekawa H, Karasuyama H: Long term maintenance of IgE-mediated memory in mast cells in the absence of detectable serum IgE. J Immunol. 2003.01; 170 (2): 775-780. ( PubMed )

Taguchi T, Kiyokawa N, Mimori K, Suzuki T, Sekino T, Nakajima H, Saito M, Katagiri YU, Matsuo N, Matsuo Y, Karasuyama H, Fujimoto J: Pre-B cell antigen receptor-mediated signal inhibits CD24-induced apoptosis in human pre-B cells. J Immunol. 2003.01; 170 (1): 252-260. ( PubMed )

Nomura M, Shimizu S, Sugiyama T, Narita M, Ito T, Matsuda H, Tsujimoto Y: 14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax. J Biol Chem. 2003.01; 278 (3): 2058-2065. ( PubMed , DOI )

Ayako Demachi, Hiroshi Nagata, Tomohiro Morio, Michiko K Oyoshi, Yu Zhang, Nobuko Tabata, Nobuhiro Kimura, Norio Shimizu, Kohtaro Yamamoto: Characterization of Epstein-Barr virus (EBV)-positive NK cells isolated from hydroa vacciniforme-like eruptions. Microbiol. Immunol.. 2003; 47 (7): 543-552. ( PubMed )

Hiroshi Hanafusa, Satoru Torii, Takayuki Yasunaga, Eisuke Nishida: Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway. Nature Cell Biology. 2002.11; 4 (11): 850-858. ( PubMed , DOI )

Akao Y, Maruyama W, Shimizu S, Yi H, Nakagawa Y, Shamoto-Nagai M, Youdim MB, Tsujimoto Y, Naoi M: Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan. J Neurochem. 2002.08; 82 (4): 913-923. ( PubMed )

Jae-Hyuck Shim, Heung-Kyu Lee, Eun-Ju Chang, Wook-Jin Chae, Jin-Hwan Han, Duck-Jong Han, Tomohiro Morio, Jung-Jin Yang, Alfred Bothwell, Sang-Kyou Lee: Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction. Proc. Natl. Acad. Sci. U.S.A.. 2002.08; 99 (16): 10617-10622. ( PubMed , DOI )

Sugiyama T, Shimizu S, Matsuoka Y, Yoneda Y, Tsujimoto Y: Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim. Oncogene. 2002.07; 21 (32): 4944-4956. ( PubMed , DOI )

Wang YH, Stephan RP, Scheffold A, Kunkel D, Karasuyama H, Radbruch A, Cooper MD: Differential surrogate light chain expression governs B-cell differentiation. Blood. 2002.04; 99 (7): 2459-2467. ( PubMed )

Tsujimoto Y, Shimizu S: The voltage-dependent anion channel: an essential player in apoptosis. Biochimie. 2002; 84 (2-3): 187-193. ( PubMed )

Stephan RP, Elgavish E, Karasuyama H, Kubagawa H, Cooper MD: Analysis of VpreB expression during B lineage differentiation in lambda5-deficient mice. J Immunol. 2001.10; 167 (7): 3734-3739. ( PubMed )

Kinoshita T, Nagata K, Sorimachi N, Karasuyama H, Sekiguchi T, Miyajima A: Oncostatin M suppresses generation of lymphoid progenitors in fetal liver by inhibiting the hepatic microenvironment. Exp Hematol. 2001.09; 29 (9): 1091-1097. ( PubMed )

Kubo S, Matsuoka K, Taya C, Kitamura F, Takai T, Yonekawa H, Karasuyama H: Drastic up-regulation of Fcepsilonri on mast cells is induced by IgE binding through stabilization and accumulation of Fcepsilonri on the cell surface. J Immunol. 2001.09; 167 (6): 3427-3434. ( PubMed )

Agematsu K, Nagumo H, Hokibara S, Mori T, Wada T, Yachie A, Kanegane H, Miyawaki T, Sugita K, Karasuyama H, Komiyama A: Complete arrest from pro- to pre-B cells in a case of B cell-negative severe combined immunodeficiency (SCID) without recombinase activating gene (RAG) mutations. Clin Exp Immunol. 2001.06; 124 (3): 461-464. ( PubMed )

Kouro T, Nagata K, Takaki S, Nisitani S, Hirano M, Wahl MI, Witte ON, Karasuyama H, Takatsu K: Bruton's tyrosine kinase is required for signaling the CD79b-mediated pro-B to pre-B cell transition. Int Immunol. 2001.04; 13 (4): 485-493. ( PubMed )

Toyama-Sorimachi N, Taguchi Y, Yagita H, Kitamura F, Kawasaki A, Koyasu S, Karasuyama H: Mouse CD94 participates in Qa-1-mediated self recognition by NK cells and delivers inhibitory signals independent of Ly-49. J Immunol. 2001.03; 166 (6): 3771-3779. ( PubMed )

Y Jin, S Nonoyama, T Morio, K Imai, H D Ochs, S Mizutani: Characterization of soluble CD40 ligand released from human activated platelets. J. Med. Dent. Sci.. 2001.03; 48 (1): 23-27. ( PubMed )

Kohara Y, Tanabe K, Matsuoka K, Kanda N, Matsuda H, Karasuyama H, Yonekawa H: A major determinant quantitative-trait locus responsible for atopic dermatitis-like skin lesions in NC/Nga mice is located on Chromosome 9. Immunogenetics. 2001.02; 53 (1): 15-21. ( PubMed )

Shimizu S, Matsuoka Y, Shinohara Y, Yoneda Y, Tsujimoto Y: Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells. J Cell Biol. 2001.01; 152 (2): 237-250. ( PubMed )

Shuichi Kubo, Kunie Matsuoka, Choji Taya, Fujiko Kitmura, Hiromichi Yonekawa, Hajime Karasuyama: IgE stabilizes its high affinity receptor (FcεRI) on mast cells in vitro and ex vivo Activating and inhibitory immunoglobulin-like receptors. 2001; 183-188.

Tsujimoto Y, Shimizu S: VDAC regulation by the Bcl-2 family of proteins. Cell Death Differ. 2000.12; 7 (12): 1174-1181. ( PubMed , DOI )

Ohnishi K, Shimizu T, Karasuyama H, Melchers F: The identification of a nonclassical cadherin expressed during B cell development and its interaction with surrogate light chain. J Biol Chem. 2000.10; 275 (40): 31134-31144. ( PubMed , DOI )

M Nagasawa, M Imai, K Imai, S Itoh, M Kajiwara, T Morio, S Nonoyama: In vivo class switch of B cells after cord blood stem cell transplantation in severe combined immune deficient (SCID) patient. Am. J. Hematol.. 2000.10; 65 (2): 176-177. ( PubMed )

S Kumaki, N Ishii, M Minegishi, Y Ohashi, I Hakozaki, S Nonoyama, K Imai, T Morio, I Tsuge, Y Sakiyama, A Miyanoshita, J Miura, M Mayumi, T Heike, K Katamura, H Takada, I Izumi, J Kamizono, S Hibi, H Sasaki, M Kimura, A Kikuta, Y Date, M Sako, H Tanaka, K Sano, K Sugamura, S Tsuchiya: Characterization of the gammac chain among 27 unrelated Japanese patients with X-linked severe combined immunodeficiency (X-SCID). Hum. Genet.. 2000.10; 107 (4): 406-408. ( PubMed )

Kusano H, Shimizu S, Koya RC, Fujita H, Kamada S, Kuzumaki N, Tsujimoto Y: Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC. Oncogene. 2000.10; 19 (42): 4807-4814. ( PubMed , DOI )

Shimizu S, Shinohara Y, Tsujimoto Y: Bax and Bcl-xL independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocator. Oncogene. 2000.09; 19 (38): 4309-4318. ( PubMed , DOI )

Nomura K, Kanegane H, Karasuyama H, Tsukada S, Agematsu K, Murakami G, Sakazume S, Sako M, Tanaka R, Kuniya Y, Komeno T, Ishihara S, Hayashi K, Kishimoto T, Miyawaki T: Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway. Blood. 2000.07; 96 (2): 610-617. ( PubMed )

Nagaoka H, Takahashi Y, Hayashi R, Nakamura T, Ishii K, Matsuda J, Ogura A, Shirakata Y, Karasuyama H, Sudo T, Nishikawa S, Tsubata T, Mizuochi T, Asano T, Sakano H, Takemori T: Ras mediates effector pathways responsible for pre-B cell survival, which is essential for the developmental progression to the late pre-B cell stage. J Exp Med. 2000.07; 192 (2): 171-182. ( PubMed )

Ellinger-Ziegelbauer H, Karasuyama H, Yamada E, Tsujikawa K, Todokoro K, Nishida E: Ste20-like kinase (SLK), a regulatory kinase for polo-like kinase (Plk) during the G2/M transition in somatic cells. Genes Cells. 2000.06; 5 (6): 491-498. ( PubMed )

Donohoe ME, Beck-Engeser GB, Lonberg N, Karasuyama H, Riley RL, Jack HM, Blomberg BB: Transgenic human lambda 5 rescues the murine lambda 5 nullizygous phenotype. J Immunol. 2000.05; 164 (10): 5269-5276. ( PubMed )

Tagawa K, Taya C, Hayashi Y, Nakagawa M, Ono Y, Fukuda R, Karasuyama H, Toyama-Sorimachi N, Katsui Y, Hata S, Ishiura S, Nonaka I, Seyama Y, Arahata K, Yonekawa H, Sorimachi H, Suzuki K: Myopathy phenotype of transgenic mice expressing active site-mutated inactive p94 skeletal muscle-specific calpain, the gene product responsible for limb girdle muscular dystrophy type 2A. Hum Mol Genet. 2000.05; 9 (9): 1393-1402. ( PubMed )

Koya RC, Fujita H, Shimizu S, Ohtsu M, Takimoto M, Tsujimoto Y, Kuzumaki N: Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release. J Biol Chem. 2000.05; 275 (20): 15343-15349. ( PubMed )

Maki K, Nagata K, Kitamura F, Takemori T, Karasuyama H: Immunoglobulin beta signaling regulates locus accessibility for ordered immunoglobulin gene rearrangements. J Exp Med. 2000.04; 191 (8): 1333-1340. ( PubMed )

Shimizu S, Ide T, Yanagida T, Tsujimoto Y: Electrophysiological study of a novel large pore formed by Bax and the voltage-dependent anion channel that is permeable to cytochrome c. J Biol Chem. 2000.04; 275 (16): 12321-12325. ( PubMed )

Shimizu S, Konishi A, Kodama T, Tsujimoto Y: BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death. Proc Natl Acad Sci USA. 2000.03; 97 (7): 3100-3105. ( PubMed )

Endo J, Toyama-Sorimachi N, Taya C, Kuramochi-Miyagawa S, Nagata K, Kuida K, Takashi T, Yonekawa H, Yoshizawa Y, Miyasaka N, Karasuyama H: Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes. FEBS Lett. 2000.02; 468 (2-3): 234-238. ( PubMed )

Shimizu S, Tsujimoto Y: Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity. Proc Natl Acad Sci USA. 2000.01; 97 (2): 577-582. ( PubMed )

S Itoh, S Nonoyama, T Morio, K Imai, H Okawa, H D Ochs, M Shimadzu, J Yata: Mutations of the WASP gene in 10 Japanese patients with Wiskott-Aldrich syndrome and X-linked thrombocytopenia. Int. J. Hematol.. 2000.01; 71 (1): 79-83. ( PubMed )

Tsujimoto Y, Shimizu S: Bcl-2 family: life-or-death switch. FEBS Lett. 2000.01; 466 (1): 6-10. ( PubMed )

Nomura M, Shimizu S, Ito T, Narita M, Matsuda H, Tsujimoto Y: Apoptotic cytosol facilitates Bax translocation to mitochondria that involves cytosolic factor regulated by Bcl-2. Cancer Res. 1999.11; 59 (21): 5542-5548. ( PubMed )

M Kajiwara, S Nonoyama, M Eguchi, T Morio, K Imai, H Okawa, M Kaneko, M Sako, S Ohga, M Maeda, S Hibi, H Hashimito, A Shibuya, H D Ochs, T Nakahata, J I Yata: WASP is involved in proliferation and differentiation of human haemopoietic progenitors in vitro. Br. J. Haematol.. 1999.11; 107 (2): 254-262. ( PubMed )

Bosma GC, Chang Y, Karasuyama H, Bosma MJ: Differential effect of an Ig mu transgene on development of pre-B cells in fetal and adult SCID mice. Proc Natl Acad Sci U S A. 1999.10; 96 (21): 11952-11957. ( PubMed )

T Morio, S H Hanissian, L B Bacharier, H Teraoka, S Nonoyama, M Seki, J Kondo, H Nakano, S K Lee, R S Geha, J Yata: Ku in the cytoplasm associates with CD40 in human B cells and translocates into the nucleus following incubation with IL-4 and anti-CD40 mAb. Immunity. 1999.09; 11 (3): 339-348. ( PubMed )

Miyazaki T, Kato I, Takeshita S, Karasuyama H, Kudo A: Lambda5 is required for rearrangement of the Ig kappa light chain gene in pro-B cell lines. Int Immunol. 1999.08; 11 (8): 1195-1202. ( PubMed )

Imazu T, Shimizu S, Tagami S, Matsushima M, Nakamura Y, Miki T, Okuyama A, Tsujimoto Y: Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability. Oncogene. 1999.08; 18 (32): 4523-4529. ( PubMed , DOI )

K Imai, S Nonoyama, H Miki, T Morio, K Fukami, Q Zhu, A Aruffo, H D Ochs, J Yata, T Takenawa: The pleckstrin homology domain of the Wiskott-Aldrich syndrome protein is involved in the organization of actin cytoskeleton. Clin. Immunol.. 1999.08; 92 (2): 128-137. ( PubMed , DOI )

Matsuoka K, Taya C, Kubo S, Toyama-Sorimachi N, Kitamura F, Ra C, Yonekawa H, Karasuyama H: Establishment of antigen-specific IgE transgenic mice to study pathological and immunobiological roles of IgE in vivo. Int Immunol. 1999.06; 11 (6): 987-994. ( PubMed )

Shimizu S, Narita M, Tsujimoto Y: Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature. 1999.06; 399 (6735): 483-487. ( PubMed , DOI )

Kuramochi S, Matsuda Y, Okamoto M, Kitamura F, Yonekawa H, Karasuyama H: Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues. Immunogenetics. 1999.05; 49 (5): 369-375. ( PubMed )

Eguchi Y, Srinivasan A, Tomaselli KJ, Shimizu S, Tsujimoto Y: ATP-dependent steps in apoptotic signal transduction. Cancer Res. 1999.05; 59 (9): 2174-2181. ( PubMed )

Tsuganezawa K, Kiyokawa N, Matsuo Y, Kitamura F, Toyama-Sorimachi N, Kuida K, Fujimoto J, Karasuyama H: Flow cytometric diagnosis of the cell lineage and developmental stage of acute lymphoblastic leukemia by novel monoclonal antibodies specific to human pre-B-cell receptor. Blood. 1998.12; 92 (11): 4317-4324. ( PubMed )

Okuno S, Shimizu S, Ito T, Nomura M, Hamada E, Tsujimoto Y, Matsuda H: Bcl-2 prevents caspase-independent cell death. J Biol Chem. 1998.12; 273 (51): 34272-34277. ( PubMed )

Narita M, Shimizu S, Ito T, Chittenden T, Lutz RJ, Matsuda H, Tsujimoto Y: Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc Natl Acad Sci USA. 1998.12; 95 (25): 14681-14686. ( PubMed )

Muto A, Hoshino H, Madisen L, Yanai N, Obinata M, Karasuyama H, Hayashi N, Nakauchi H, Yamamoto M, Groudine M, Igarashi K: Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer. EMBO J. 1998.10; 17 (19): 5734-5743. ( PubMed , DOI )

S Nonoyama, S Tsukada, T Yamadori, T Miyawaki, Y Z Jin, C Watanabe, T Morio, J Yata, H D Ochs: Functional analysis of peripheral blood B cells in patients with X-linked agammaglobulinemia. J. Immunol.. 1998.10; 161 (8): 3925-3929. ( PubMed )

Meffre E, Papavasiliou F, Cohen P, de Bouteiller O, Bell D, Karasuyama H, Schiff C, Banchereau J, Liu YJ, Nussenzweig MC: Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells. J Exp Med. 1998.08; 188 (4): 765-772. ( PubMed )

Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H, Su MS, Rakic P, Flavell RA: Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell. 1998.08; 94 (3): 325-337. ( PubMed )

Tanabe H, Eguchi Y, Shimizu S, Martinou JC, Tsujimoto Y: Death-signalling cascade in mouse cerebellar granule neurons. Eur J Neurosci. 1998.04; 10 (4): 1403-1411. ( PubMed )

Yoshimura S, Banno Y, Nakashima S, Takenaka K, Sakai H, Nishimura Y, Sakai N, Shimizu S, Eguchi Y, Tsujimoto Y, Nozawa Y: Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activation. J Biol Chem. 1998.03; 273 (12): 6921-6927. ( PubMed )

Shimizu S, Eguchi Y, Kamiike W, Funahashi Y, Mignon A, Lacronique V, Matsuda H, Tsujimoto Y: Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux. Proc Natl Acad Sci USA. 1998.02; 95 (4): 1455-1459. ( PubMed )

Yamabe K, Shimizu S, Kamiike W, Waguri S, Eguchi Y, Hasegawa J, Okuno S, Yoshioka Y, Ito T, Sawa Y, Uchiyama Y, Tsujimoto Y, Matsuda H: Prevention of hypoxic liver cell necrosis by in vivo human bcl-2 gene transfection. Biochem Biophys Res Commun. 1998.02; 243 (1): 217-223. ( PubMed )

Shimizu S, Tsujimoto Y: [Molecular mechanism of apoptosis]. Seikagaku. 1998.01; 70 (1): 14-21. ( PubMed )

Koyama M, Ishihara K, Karasuyama H, Cordell JL, Iwamoto A, Nakamura T: CD79 alpha/CD79 beta heterodimers are expressed on pro-B cell surfaces without associated mu heavy chain. Int Immunol. 1997.11; 9 (11): 1767-1772. ( PubMed )

Nagata K, Nakamura T, Kitamura F, Kuramochi S, Taki S, Campbell KS, Karasuyama H: The Ig alpha/Igbeta heterodimer on mu-negative proB cells is competent for transducing signals to induce early B cell differentiation. Immunity. 1997.10; 7 (4): 559-570. ( PubMed )

Kuramochi S, Moriguchi T, Kuida K, Endo J, Semba K, Nishida E, Karasuyama H: LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes. J Biol Chem. 1997.09; 272 (36): 22679-22684. ( PubMed )

Ohtsu M, Sakai N, Fujita H, Kashiwagi M, Gasa S, Shimizu S, Eguchi Y, Tsujimoto Y, Sakiyama Y, Kobayashi K, Kuzumaki N: Inhibition of apoptosis by the actin-regulatory protein gelsolin. EMBO J. 1997.08; 16 (15): 4650-4656. ( PubMed , DOI )

Emoto K, Toyama-Sorimachi N, Karasuyama H, Inoue K, Umeda M: Exposure of phosphatidylethanolamine on the surface of apoptotic cells. Exp Cell Res. 1997.05; 232 (2): 430-434. ( PubMed , DOI )

Eguchi Y, Shimizu S, Tsujimoto Y: Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res. 1997.05; 57 (10): 1835-1840. ( PubMed )

Karasuyama H, Nakamura T, Nagata K, Kuramochi T, Kitamura F, Kuida K: The roles of preB cell receptor in early B cell development and its signal transduction. Immunol Cell Biol. 1997.04; 75 (2): 209-216. ( PubMed , DOI )

T Morio, T Chatila, R S Geha: HIV glycoprotein gp120 inhibits TCR-CD3-mediated activation of fyn and lck. Int. Immunol.. 1997.01; 9 (1): 53-64. ( PubMed )

Shimizu S, Eguchi Y, Kamiike W, Akao Y, Kosaka H, Hasegawa J, Matsuda H, Tsujimoto Y: Involvement of ICE family proteases in apoptosis induced by reoxygenation of hypoxic hepatocytes. Am J Physiol. 1996.12; 271 (6 Pt 1): G949-58. ( PubMed )

Kuida K, Zheng TS, Na S, Kuan C, Yang D, Karasuyama H, Rakic P, Flavell RA: Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature. 1996.11; 384 (6607): 368-372. ( PubMed , DOI )

K Kawabata, M Nagasawa, T Morio, H Okawa, J Yata: Decreased alpha/beta heterodimer among CD8 molecules of peripheral blood T cells in Wiskott-Aldrich syndrome. Clin. Immunol. Immunopathol.. 1996.11; 81 (2): 129-135. ( PubMed )

Morimoto Y, Kamiike W, Nishida T, Hatanaka N, Shimizu S, Huang TP, Hamada E, Uchiyama Y, Yoshida Y, Furuya E, Matsuda H: Improvement of rat liver graft function by insulin administration to donor. Gastroenterology. 1996.10; 111 (4): 1071-1080. ( PubMed )

Maki K, Sunaga S, Komagata Y, Kodaira Y, Mabuchi A, Karasuyama H, Yokomuro K, Miyazaki JI, Ikuta K: Interleukin 7 receptor-deficient mice lack gammadelta T cells. Proc Natl Acad Sci U S A. 1996.07; 93 (14): 7172-7177. ( PubMed )

Shimizu S, Eguchi Y, Kamiike W, Waguri S, Uchiyama Y, Matsuda H, Tsujimoto Y: Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors. Oncogene. 1996.07; 13 (1): 21-29. ( PubMed )

Shimizu S, Eguchi Y, Kamiike W, Matsuda H, Tsujimoto Y: Bcl-2 expression prevents activation of the ICE protease cascade. Oncogene. 1996.06; 12 (11): 2251-2257. ( PubMed )

Shimizu S, Eguchi Y, Kamiike W, Waguri S, Uchiyama Y, Matsuda H, Tsujimoto Y: Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: possible involvement of common mediators in apoptotic and necrotic signal transductions. Oncogene. 1996.05; 12 (10): 2045-2050. ( PubMed )

Shimizu S, Eguchi Y, Kamiike W, Itoh Y, Hasegawa J, Yamabe K, Otsuki Y, Matsuda H, Tsujimoto Y: Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL. Cancer Res. 1996.05; 56 (9): 2161-2166. ( PubMed )

Hasegawa J, Kamada S, Kamiike W, Shimizu S, Imazu T, Matsuda H, Tsujimoto Y: Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis. Cancer Res. 1996.04; 56 (8): 1713-1718. ( PubMed )

Karasuyama H, Rolink A, Melchers F: Surrogate light chain in B cell development. Adv Immunol. 1996; 63 1-41. ( PubMed )

T Morio, S Hanissian, R S Geha: Characterization of a 23-kDa protein associated with CD40. Proc. Natl. Acad. Sci. U.S.A.. 1995.12; 92 (25): 11633-11636. ( PubMed )

T Kondoh, K Hayashi, T Matsumoto, M Yoshimoto, T Morio, J Yata, Y Tsuji: Two sisters with clinical diagnosis of Wiskott-Aldrich syndrome: is the condition in the family autosomal recessive? Am. J. Med. Genet.. 1995.10; 60 (5): 364-369. ( PubMed , DOI )

N Ramesh, T Morio, R Fuleihan, M Worm, A Horner, E Tsitsikov, E Castigli, R S Geha: CD40-CD40 ligand (CD40L) interactions and X-linked hyperIgM syndrome (HIGMX-1). Clin. Immunol. Immunopathol.. 1995.09; 76 (3 Pt 2): S208-S213. ( PubMed )

Sawai H, Yamasaki N, Shigeta M, Komori S, Karasuyama H, Koyama K, Isojima S: Direct production of the Fab fragment derived from the sperm immobilizing antibody using polymerase chain reaction and cDNA expression vectors. Am J Reprod Immunol. 1995.07; 34 (1): 26-34. ( PubMed )

Rolink A, Ghia P, Grawunder U, Haasner D, Karasuyama H, Kalberer C, Winkler T, Melchers F: In-vitro analyses of mechanisms of B-cell development. Semin Immunol. 1995.06; 7 (3): 155-167. ( PubMed )

Y Mizuno, T Morio, T Hara: Peripheral expansion of V delta 1-J delta 1/J delta 2+ gamma delta T cells and large granular lymphocytes in a patient with Wiskott-Aldrich syndrome. Acta Paediatr Jpn. 1995.06; 37 (3): 394-398. ( PubMed )

Melchers F, Rolink A, Grawunder U, Winkler TH, Karasuyama H, Ghia P, Andersson J: Positive and negative selection events during B lymphopoiesis. Curr Opin Immunol. 1995.04; 7 (2): 214-227. ( PubMed )

Shimizu S, Eguchi Y, Kosaka H, Kamiike W, Matsuda H, Tsujimoto Y: Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL. Nature. 1995.04; 374 (6525): 811-813. ( PubMed , DOI )

Winkler TH, Rolink A, Melchers F, Karasuyama H: Precursor B cells of mouse bone marrow express two different complexes with the surrogate light chain on the surface. Eur J Immunol. 1995.02; 25 (2): 446-450. ( PubMed )

Shimizu S, Kamiike W, Hatanaka N, Yoshida Y, Tagawa K, Miyata M, Matsuda H: New method for measuring ICG Rmax with a clearance meter. World J Surg. 1995; 19 (1): 113-8; discussion 118. ( PubMed )

Fujikawa M, Kamiike W, Hatanaka N, Shimizu S, Akashi A, Miyata M, Kurosawa K, Yoshida Y, Tagawa K, Matsuda H: Changes in biliary glutathione level during ischemia-reperfusion of rat liver. J Surg Res. 1994.11; 57 (5): 569-573. ( PubMed , DOI )

Rolink A, Grawunder U, Winkler TH, Karasuyama H, Melchers F: IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development. Int Immunol. 1994.08; 6 (8): 1257-1264. ( PubMed )

M Nagasawa, T Morio, S Takagi, J Yata: Differences of LAK-activity and IL-2 responsiveness between alpha/beta and gamma/delta T cells which developed after thymus transplantation. Acta Paediatr Jpn. 1994.08; 36 (4): 396-403. ( PubMed )

Shimizu S, Kamiike W, Hatanaka N, Miyata M, Inoue T, Yoshida Y, Tagawa K, Matsuda H: Beneficial effects of cyclosporine on reoxygenation injury in hypoxic rat liver. Transplantation. 1994.06; 57 (11): 1562-1566. ( PubMed )

Karasuyama H, Rolink A, Shinkai Y, Young F, Alt FW, Melchers F: The expression of Vpre-B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice. Cell. 1994.04; 77 (1): 133-143. ( PubMed )

Hatanaka N, Kamiike W, Morimoto Y, Shimizu S, Miyata M, Yoshida Y, Matsuda H: Protective effects of feeding and of fructose against hypoxic damage in the perfused liver. Transplant Proc. 1994.04; 26 (2): 916-917. ( PubMed )

T Morio, R S Geha, T A Chatila: Engagement of MHC class II molecules by staphylococcal superantigens activates src-type protein tyrosine kinases. Eur. J. Immunol.. 1994.03; 24 (3): 651-658. ( PubMed , DOI )

Rolink A, Karasuyama H, Haasner D, Grawunder U, Martensson IL, Kudo A, Melchers F: Two pathways of B-lymphocyte development in mouse bone marrow and the roles of surrogate L chain in this development. Immunol Rev. 1994.02; 137 185-201. ( PubMed )

N S Trede, T Morio, P R Scholl, R S Geha, T Chatila: Early activation events induced by the staphylococcal superantigen toxic shock syndrome toxin-1 in human peripheral blood monocytes. Clin. Immunol. Immunopathol.. 1994.02; 70 (2): 137-144. ( PubMed )

C L Ren, T Morio, S M Fu, R S Geha: Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase Cγ2. J. Exp. Med.. 1994.02; 179 (2): 673-680. ( PubMed )

Melchers F, Haasner D, Grawunder U, Kalberer C, Karasuyama H, Winkler T, Rolink AG: Roles of IgH and L chains and of surrogate H and L chains in the development of cells of the B lymphocyte lineage. Annu Rev Immunol. 1994; 12 209-225. ( PubMed , DOI )

Kamiike W, Miyata M, Izukura M, Itoh T, Nezu R, Nakamuro M, Hatanaka N, Shimizu S, Takahashi T, Shimazaki Y: Simultaneous surgery for coronary artery disease and gastric cancer. World J Surg. 1994; 18 (6): 879-81; discussion 882. ( PubMed )

H Hamaguchi, Y Nakamura, K Nagata, S Shiba, H Arimura, K Muroga, S Miyake, Y Ohkawa, T Morio: Philadelphia-chromosome-positive, monosomy 7 biphenotypic acute mixed lineage leukemia in adults: a pluripotent stem cell disorder. Leukemia. 1993.11; 7 (11): 1752-1758. ( PubMed )

Karasuyama H, Rolink A, Melchers F: A complex of glycoproteins is associated with VpreB/lambda 5 surrogate light chain on the surface of mu heavy chain-negative early precursor B cell lines. J Exp Med. 1993.08; 178 (2): 469-478. ( PubMed )

Rolink A, Karasuyama H, Grawunder U, Haasner D, Kudo A, Melchers F: B cell development in mice with a defective lambda 5 gene. Eur J Immunol. 1993.06; 23 (6): 1284-1288. ( PubMed )

Sawai H, Yamasaki N, Komori S, Karasuyama H, Isojima S: Stable production of recombinant human sperm immobilizing antibody using cDNA expression vectors. Am J Reprod Immunol. 1993.03; 29 (2): 100-108. ( PubMed )

Melchers F, Karasuyama H, Haasner D, Bauer S, Kudo A, Sakaguchi N, Jameson B, Rolink A: The surrogate light chain in B-cell development. Immunol Today. 1993.02; 14 (2): 60-68. ( PubMed )

Uemura N, Ozawa K, Tojo A, Takahashi K, Okano A, Karasuyama H, Tani K, Asano S: Acquisition of interleukin-3 independence in FDC-P2 cells after transfection with the activated c-H-ras gene using a bovine papillomavirus-based plasmid vector. Blood. 1992.12; 80 (12): 3198-3204. ( PubMed )

Okawa H, Nagasawa M, Morio T, Takase K, Tanaka K, Yata J, Dan K, Nomura T, Sakamaki H, Onozawa Y, et al.: Peroxidase-negative and myelomonocytic antigen-positive acute leukemia. Int J Hematol. 1992.04; 55 (2): 165-171. ( PubMed )

Melchers F, Haasner D, Karasuyama H, Reininger L, Rolink A: Progenitor and precursor B lymphocytes of mice. Proliferation and differentiation in vitro and population, differentiation and turnover in SCID mice in vivo of normal and abnormal cells. Curr Top Microbiol Immunol. 1992; 182 3-12. ( PubMed )

T Morio, M Nagasawa, J Yata: Gamma-delta T cells in patients with primary immunodeficiency syndrome: their function and a possible role in the pathogenesis. Chem. Immunol.. 1992; 53 102-120. ( PubMed )

T Chatila, P Scholl, N Ramesh, N Trede, R Fuleihan, T Morio, R S Geha: Cellular and molecular mechanisms of immune activation by microbial superantigens: studies using toxic shock syndrome toxin-1. Chem. Immunol.. 1992; 55 146-171. ( PubMed )

Golumbek PT, Lazenby AJ, Levitsky HI, Jaffee LM, Karasuyama H, Baker M, Pardoll DM: Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4. Science. 1991.11; 254 (5032): 713-716. ( PubMed )

Yamamura Y, Kotani M, Chowdhury MI, Yamamoto N, Yamaguchi K, Karasuyama H, Katsura Y, Miyasaka M: Infection of human CD4+ rabbit cells with HIV-1: the possibility of the rabbit as a model for HIV-1 infection. Int Immunol. 1991.11; 3 (11): 1183-1187. ( PubMed )

Tanaka T, Tsudo M, Karasuyama H, Kitamura F, Kono T, Hatakeyama M, Taniguchi T, Miyasaka M: A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL-4 cells. J Immunol. 1991.10; 147 (7): 2222-2228. ( PubMed )

Suzuki T, Bessho M, Hirashima K, Tohda S, Nagata K, Morio T, Imai Y, Nara N: Enhancement by transforming growth factor-beta 1 (TGF-beta 1) of the proliferation of leukemic blast progenitors stimulated with IL-3. J Cell Physiol. 1991.09; 148 (3): 396-403. ( PubMed , DOI )

M Nagasawa, T Morio, S Takagi, J Yata: Generation and function of γδ T cells after allogeneic bone marrow transplantation in humans: comparison in absence or presence of HLA-matched or mismatched thymus. Acta Paediatr Jpn. 1991.04; 33 (2): 146-158. ( PubMed )

Rolink A, Kudo A, Karasuyama H, Kikuchi Y, Melchers F: Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo. EMBO J. 1991.02; 10 (2): 327-336. ( PubMed )

Tanaka T, Tsudo M, Karasuyama H, Toyama N, Hatakeyama M, Taniguchi T, Miyasaka M: Signal transduction through the human IL-2 receptor beta-chain expressed in IL-6-dependent mouse B cell hybridoma. Int Immunol. 1991.01; 3 (1): 105-108. ( PubMed )

Miyajima H, Hirano T, Hirose S, Karasuyama H, Okumura K, Ovary Z: Suppression by IL-2 of IgE production by B cells stimulated by IL-4. J Immunol. 1991.01; 146 (2): 457-462. ( PubMed )

Yamamura Y, Kotani M, Tsudo M, Karasuyama H, Seto A, Miyasaka M: IL-2 receptors on rabbit T-cell lines and their transfectants expressing the human IL-2 receptor alpha chain. Immunology. 1990.12; 71 (4): 502-507. ( PubMed )

Suzuki T, Morio T, Tohda S, Nagata K, Yamashita Y, Imai Y, Aoki N, Hirashima K, Nara N: Effects of interleukin-6 and granulocyte colony-stimulating factor on the proliferation of leukemic blast progenitors from acute myeloblastic leukemia patients. Jpn J Cancer Res. 1990.10; 81 (10): 979-986. ( PubMed )

Karasuyama H, Kudo A, Melchers F: The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain. J Exp Med. 1990.09; 172 (3): 969-972. ( PubMed )

Tohda S, Morio T, Suzuki T, Nagata K, Kamiyama T, Imai Y, Nara N, Aoki N: Richter syndrome with two B cell clones possessing different surface immunoglobulins and immunoglobulin gene rearrangements. Am J Hematol. 1990.09; 35 (1): 32-36. ( PubMed )

Tsudo M, Karasuyama H, Kitamura F, Tanaka T, Kubo S, Yamamura Y, Tamatani T, Hatakeyama M, Taniguchi T, Miyasaka M: The IL-2 receptor beta-chain (p70). Ligand binding ability of the cDNA-encoding membrane and secreted forms. J Immunol. 1990.07; 145 (2): 599-606. ( PubMed )

Nara N, Suzuki T, Nagata K, Tohda S, Yamashita Y, Nakamura Y, Imai Y, Morio T, Minamihisamatsu M: Granulocyte colony-stimulating factor-dependent growth of an acute myeloblastic leukemia cell line. Jpn J Cancer Res. 1990.06; 81 (6-7): 625-631. ( PubMed )

Tohyama N, Karasuyama H, Tada T: Growth autonomy and tumorigenicity of interleukin 6-dependent B cells transfected with interleukin 6 cDNA. J Exp Med. 1990.02; 171 (2): 389-400. ( PubMed )

Fearon ER, Pardoll DM, Itaya T, Golumbek P, Levitsky HI, Simons JW, Karasuyama H, Vogelstein B, Frost P: Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response. Cell. 1990.02; 60 (3): 397-403. ( PubMed )

T Morio, M Nagasawa, S Nonoyama, H Okawa, J Yata: Phenotypic profile and functions of T cell receptor-γδ-bearing cells from patients with primary immunodeficiency syndrome. J. Immunol.. 1990.02; 144 (4): 1270-1275. ( PubMed )

Sano K, Kishimoto H, Karasuyama H, Asano Y, Tada T: Cell division-associated expression of an epitope, KH17, on early developing thymocytes. Int Immunol. 1990; 2 (8): 725-733. ( PubMed )

Nara N, Tohda S, Suzuki T, Nagata K, Yamashita Y, Imai Y, Morio T, Bessho M, Shibuya A, Adachi Y: Terminal differentiation to mature neutrophils and eosinophils in suspension culture of the blast progenitors in acute myeloblastic leukemia. Hematol Pathol. 1990; 4 (3): 125-134. ( PubMed )

Tsudo M, Karasuyama H, Kitamura F, Nagasaka Y, Tanaka T, Miyasaka M: Reconstitution of a functional IL-2 receptor by the beta-chain cDNA. A newly acquired receptor transduces negative signal. J Immunol. 1989.12; 143 (12): 4039-4043. ( PubMed )

T Morio, S Nonoyama, J Yata: Suppression of in vitro immunoglobulin synthesis by CD16(Leu11a)+ CD56 (NKH1,Leu19)+non-T lineage NK cells; lack of suppression of cells from immunodeficient patients. Clin. Exp. Immunol.. 1989.11; 78 (2): 159-165. ( PubMed )

Sato T, Kohno S, Kobayashi H, Yoshida K, Karasuyama H, Tabata T: [Prosthetic application of a new measuring instrument of the dynamic periodontal function] Nihon Hotetsu Shika Gakkai Zasshi. 1989.10; 33 (5): 1202-1211. ( PubMed )

Tani K, Ozawa K, Ogura H, Takahashi T, Okano A, Watari K, Matsudaira T, Tajika K, Karasuyama H, Nagata S, et al.: Implantation of fibroblasts transfected with human granulocyte colony-stimulating factor cDNA into mice as a model of cytokine-supplement gene therapy. Blood. 1989.09; 74 (4): 1274-1280. ( PubMed )

Tonouchi N, Miwa K, Karasuyama H, Matsui H: Deletion of 3' untranslated region of human BSF-2 mRNA causes stabilization of the mRNA and high-level expression in mouse NIH3T3 cells. Biochem Biophys Res Commun. 1989.09; 163 (2): 1056-1062. ( PubMed )

T Morio, K Takase, H Okawa, M Oguchi, M Kanbara, F Hiruma, K Yoshino, T Kaneko, S Asamura, T Inoue: The increase of non-MHC-restricted cytotoxic cells (γδ-TCR-bearing T cells or NK cells) and the abnormal differentiation of B cells in Wiskott-Aldrich syndrome. Clin. Immunol. Immunopathol.. 1989.08; 52 (2): 279-290. ( PubMed )

Karasuyama H, Tohyama N, Tada T: Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene. J Exp Med. 1989.01; 169 (1): 13-25. ( PubMed )

Yagita H, Nakamura T, Karasuyama H, Okumura K: Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells. Proc Natl Acad Sci U S A. 1989.01; 86 (2): 645-649. ( PubMed )

Melchers F, Bauer SR, Berger C, Karasuyama H, Kudo A, Rolink A, Sakaguchi N, Strasser A, Thalmann P: Precursor B lymphocytes--specific monoclonal antibodies and genes. Adv Exp Med Biol. 1989; 254 87-93. ( PubMed )

Karasuyama H: [Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using high-copy cDNA expression vectors] Tanpakushitsu Kakusan Koso. 1988.11; 33 (14): 2527-2532. ( PubMed )

Kohno S, Karasuyama H, Yoshida K, Kobayashi H: [A study on the causative mechanism of occlusal interference on the balancing side] Nihon Hotetsu Shika Gakkai Zasshi. 1988.04; 32 (2): 505-513. ( PubMed )

Karasuyama H, Rolink A, Melchers F: Recombinant interleukin 2 or 5, but not 3 or 4, induces maturation of resting mouse B lymphocytes and propagates proliferation of activated B cell blasts. J Exp Med. 1988.04; 167 (4): 1377-1390. ( PubMed )

Karasuyama H, Melchers F: Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors. Eur J Immunol. 1988.01; 18 (1): 97-104. ( PubMed )

Asano Y, Nakayama T, Kubo M, Fujisawa I, Karasuyama H, Singer A, Hodes RJ, Tada T: Analysis of two distinct B cell activation pathways mediated by a monoclonal T helper cell. II. T helper cell secretion of interleukin 4 selectively inhibits antigen-specific B cell activation by cognate, but not noncognate, interactions with T cells. J Immunol. 1988.01; 140 (2): 419-426. ( PubMed )

Palacios R, Karasuyama H, Rolink A: Ly1+ PRO-B lymphocyte clones. Phenotype, growth requirements and differentiation in vitro and in vivo. EMBO J. 1987.12; 6 (12): 3687-3693. ( PubMed )

Staerz UD, Karasuyama H, Garner AM: Cytotoxic T lymphocytes against a soluble protein. Nature. 1987.10; 329 (6138): 449-451. ( PubMed , DOI )

Lernhardt W, Karasuyama H, Rolink A, Melchers F: Control of the cell cycle of murine B lymphocytes: the nature of alpha- and beta-B-cell growth factors and of B-cell maturation factors. Immunol Rev. 1987.10; 99 241-262. ( PubMed )

Karasuyama H, Kim M, Okumura K, Tada T: Heterogeneity of Igh-linked allotypic determinants expressed on functional T cell subsets as detected by monoclonal antibodies. Eur J Immunol. 1984.05; 14 (5): 413-420. ( PubMed )

Abe R, Karasuyama H, Yagi J, Tada T: Regulation of allotype-linked NPb idiotype by an idiotype-positive soluble factor derived from a T cell hybridoma. Coupling of the circuit regulation to the network concept. Int Arch Allergy Appl Immunol. 1984; 74 (4): 289-296. ( PubMed )

Tada T, Okumura K, Yamada S, Kitahara T, Karasuyama H, Ochi A, Yamauchi K: Regulation of tumor-specific immune response by T cell products. Prog Clin Biol Res. 1983; 132B 345-351. ( PubMed )

Tada T, Okumura K, Miyatani S, Ochi A, Nakauchi H, Karasuyama H: Restricting elements in the immunological circuitry: the role of I region-controlled determinants. Ann N Y Acad Sci. 1983; 418 189-197. ( PubMed )