1. Hitoshi Okazawa. DEVELOPMENT OF ANTI-HMGB1 ANTIBODY FOR DEMENTIAS. ADPD2024 2024.03.08 LisbonCongressCentre(Lisbon, Portugal)

  1. Hitoshi Okazawa. Development of HMGB1 antibody therapy against neurodegenerative dementias. The 42nd Annual Meeting of Japan Society for Dementia Research 2023.11.24 Nara Prefectural Convention Center(Nara)

  2. Hikari Tanaka, Xiaocen Jin, Meihua Jin, Kyota Fujita, Hidenori Homma, Miako Inotsume, Huang Yong, Kenichi Umeda, Noriyuki Kodera, Toshio Ando, Hitoshi Okazawa. PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions. 2023.08.04 Sendai International Center (Miyagi Sendai)

  3. Kyota Fujita, Hitoshi Okazawa. DNA damage repair and neurodegeneration. 64th Annual Meeting of the Japanese Society of Neurology 2023.06.02 MakuhariMesse(Chiba)

  4. Hitoshi Okazawa. Neuroinflammation and neurodegeneration. 64th Annual Meeting of the Japanese Society of Neurology 2023.06.02 MakuhariMesse(Chiba)

  5. Xiaocen Jin, Hikari Tanaka, Meihua Jin, Kyota Fujita, Hidenori Homma, Maiko Inotsume, Huang Yong, Kenichi Umeda, Noriyuki Kodera, Toshio Ando, Hitoshi Okazawa. PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions. The 15th CBIR Symposium Inspiring the Next Generation (online) 2023.02.17

  1. Hitoshi Okazawa. Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation. The 51st Annual Meeting of the Japanese Society for Immunology(JSI2022) 2022.12.08 Kumamoto-Jo Hall(Kumamoto)

  2. Tanaka Hikari, Homma Hidenori, Fujita Kyota, Kondo Kanoh, Jin Xiaocen, Jin Meihua, Yoshioka Yuki, Takayama Sumire, Tagawa Kazuhiko, Okazawa Hitoshi. アルツハイマー病病態における超早期のYAP依存性壊死の影響(Effect of YAP-dependent necrosis in the ultra early stage on Alzheimer's disease pathology). 臨床神経学 2022.10.01

  3. 田中 ひかり, 金 美花, 塩飽 裕紀, 吉岡 優希, 金 キョウシン, 近藤 和, 藤田 慶大, 本間 秀典, 岡澤 均. 脳炎症における知的障害原因遺伝子PQBP1の役割. Dementia Japan 2022.10.01

  4. Hikari Tanaka, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuhiko Tagawa, Xiaocen Jin, Meihua Jin, Yuki Yoshioka, Sumire Takayama, Hitoshi Okazawa. HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology. NEURO2022 2022.07.03

  5. Hikari Tanaka, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuhiko Tagawa, Xiaocen Jin, Meihua Jin, Yuki Yoshioka, Sumire Takayama, Hitoshi Okazawa. HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology. NEURO2022 2022.07.03 Okinawa Convention Center(Okinawa)

  6. Meihua Jin, Hiroki Shiwaku, Hikari Tanaka, Yuki Yoshioka, Xiaocen Jin, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Hitoshi Okazawa. Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation. NEURO2022 2022.07.01

  7. Meihua Jin, Hiroki Shiwaku, Hikari Tanaka, Yuki Yoshioka, Xiaocen Jin, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Hitoshi Okazawa. Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation. NEURO2022 2022.07.01 Okinawa Convention Center(Okinawa)

  8. Hikari Tanaka, Hidenori Homma, Kyota Fujita, Kanoh Kondo, Xiaocen Jin, Meihua Jin, Yuki Yoshioka, Sumire Takayama, Kazuhiko Tagawa, Hitoshi Okazawa. Effect of YAP-dependent necrosis in the ultra early stage on Alzheimer's disease pathology. 第63回日本神経学会学術大会 2022.05.20

  9. Kyota Fujita, Hidenori Homma, Hikari Tanaka, Meihua Jin, Xiaocen Jin, Yong Huang, Yuki Yoshioka, Kanoh Kondo, Hiroki Shiwaku, Kazuhiko Tagawa, Hitoshi Okazawa. DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis. 第63回日本神経学会学術大会 2022.05.20

  10. Kyota Fujita, Hidenori Homma, Hikari Tanaka, Meihua Jin, Xiaocen Jin, Yong Huang, Yuki Yoshioka, Kanoh Kondo, Hiroki Shiwaku, Kazuhiko Tagawa, Hitoshi Okazawa. DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis. 63rd Annual Meeting of the Japanese Society of Neurology 2022.05.20 Tokyo International Forum(Tokyo)

  11. Hikari Tanaka, Hidenori Homma, Kyota Fujita, Kanoh Kondo, Xiaocen Jin, Meihua Jin, Yuki Yoshioka, Sumire Takayama, Kazuhiko Tagawa, Hitoshi Okazawa. Effect of YAP-dependent necrosis in the ultra early stage on Alzheimer's disease pathology. 63rd Annual Meeting of the Japanese Society of Neurology 2022.05.20 Tokyo International Forum(Tokyo)

  12. Meihua Jin, Hiroki Shiwaku, Hikari Tanaka, Takayuki Obita, Sakurako Ohuchi, Yuki Yoshioka, Xiaocen Jin, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuyuki Nakajima, Mineyuki Mizuguchi, Hitoshi Okazawa. Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain Inflammation. The 14th CBIR Symposium Inspiring the Next Generation(online) 2022.02.17

  1. Hitoshi Okazawa. Big data-driven research of neurodegenerative diseases. 62nd Annual Meeting of the Japanese Society of Neurology 2021.05.20 ICCKyoto(Kyoto)

  2. Hitoshi Okazawa. Deciphering and tacking the ultra-early phase pathology of Alzheimer’s disease. The 15th International Conference on Alzheimer’s and Parkinson’s Diseases (online) 2021.03.11

  1. Tanaka Hikari, Kondo Kanoh, Chen Xigui, Homma Hidenori, Tagawa Kazuhiko, Saido Takaomi, Muramatsu Shin-ichi, Fujita Kyota, Okazawa Hitoshi. 超早期アルツハイマー病においてSRRM2リン酸化はシナプス病理を誘発する(Phosphorylation of SRRM2 leads to synaptic pathology at ultra-early phase of Alzheimer's disease). 臨床神経学 2020.11.01

  2. Tanaka Hikari, Kondo Kanoh, Chen Xigui, Homma Hidenori, Tagawa Kazuhiko, Saido Takaomi, Muramatsu Shin-ichi, Fujita Kyota, Okazawa Hitoshi. 超早期アルツハイマー病においてSRRM2リン酸化はシナプス病理を誘発する(Phosphorylation of SRRM2 leads to synaptic pathology at ultra-early phase of Alzheimer's disease). 臨床神経学 2020.11.01

  3. Tanaka. H, Kondo. K, Chen. X, Homma. H, Tagawa. K, Saido. T, Muramatsu. S, Fujita. K, Okazawa. H. Phosphorylation of SRRM2 leads to synaptic pathology at ultra-early phase of Alzheimer's disease.. 61st Annual Meeting of the Japanese Society of Neurology 2020.09.02

  4. Hikari Tanaka, Kanoh Kondo, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Takaomi Saido, Shin-ichi Muramatsu, Kyota Fujita, Hitoshi Okazawa. Phosphorylation of SRRM2 leads to synaptic pathology at ultra-early phase of Alzheimer's disease. 61st Annual Meeting of the Japanese Society of Neurology 2020.09.02 Okayama Convention Center(Okayama)

  5. Tanaka. H, Homma. H, Fujita. K, Kondo. K, Jin. X, Tagawa. K, Okazawa. H. YAP-dependent necrosis regulates early stages of Alzheimer’s disease pathology. The 43rd Annual Meeting of the Japan Neuroscience Society 2020.07.31

  6. Hitoshi Okazawa. Discovery of new pathologies and development of new therapeutics based on molecular network analysis against Alzheimer's disease. The 43rd Annual Meeting of the Japan Neuroscience Society(online) 2020.07.31

  7. Hikari Tanaka, Hidenori Homma, Kyota Fujita, Kanoh Kondo, Jin Xiaocen, Kazuhiko Tagawa, Hitoshi Okazawa. YAP-dependent necrosis regulates early stages of Alzheimer’s disease pathology. The 43rd Annual Meeting of the Japan Neuroscience Society(online) 2020.07.31

  8. Hitoshi Okazawa. Development of gene therapies of neurodegenerative diseases targeting new pathological mechanisms. AMED -Gene & Cell Therapy Symposium 2020.02.22 Nihonbashi Life Science Building(Tokyo)

  1. Hitoshi Okazawa. Ultra-early phase pathology of neurodegeneration. China-Japan High-end Forum on Medical and Health Cooperation 2019.12.21 Jinan University (Guangzhou, China)

  2. Hitoshi Okazawa. Alzheimer's disease and Autophagy. The 38th Annual Meeting of Japan Society for Dementia Research 2019.11.07 Keio Plaza Hotel(Tokyo)

  3. Hitoshi Okazawa. New therapeutics development against ultra-early phase AD pathology. The 38th Annual Meeting of Japan Society for Dementia Research 2019.11.07 Keio Plaza Hotel(Tokyo)

  4. Hitoshi Okazawa. HMGB1 and Neurodegeneration. 9th International DAMPs and Alarmins Symposium 2019.11.06 Okayama University Shikata Campus(Okayama)

  5. Fujita Kyota, Chen Xigui, Homma Hidenori, Tagawa Kazuhiko, Okazawa Hitoshi. Tyro3を治療標的とすることでタウを介したシナプス病理によりPGRN変異体FTLD-TDPモデルに改善を認めた(Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology). 臨床神経学 2019.11.01

  6. Fujita Kyota, Chen Xigui, Homma Hidenori, Tagawa Kazuhiko, Okazawa Hitoshi. Tyro3を治療標的とすることでタウを介したシナプス病理によりPGRN変異体FTLD-TDPモデルに改善を認めた(Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology). 臨床神経学 2019.11.01

  7. Hitoshi Okazawa. Targeting HMGB1-mediated expansion of neurodegeneration at the ultra-early phase pathology of Alzheimer’s disease. AsCNP2019 2019.10.12 Fukuoka Sunpalace Hotel and Hall (Fukuoka)

  8. Kyota Fujita, Hidenori Homma, Kanoh Kondo, Kazuhiko Tagawa, Hitoshi Okazawa. Ser46-phosphorylated MARCKS is a common mechanism of pre-aggregation neurite degeneration in across multiple dementia. NEURO2019 2019.07.27 Toki Messe(Niigata)

  9. Hikari Tanaka, Kanoh Kondo, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Aurelian Kerever, Shigeki Aoki, Takashi Saito, Takaomi Saido, Shin-ichi Muramatsu, Kyota Fujita, Hitoshi Okazawa. The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology. NEURO2019 2019.07.27 Toki Messe(Niigata)

  10. Kyota Fujita, Hidenori Homma, Kanoh Kondo, Kazuhiko Tagawa, Hitoshi Okazawa . Ser46-phosphorylated MARCKS is a common mechanism of pre-aggregation neurite degeneration in across multiple dementia. NEURO2019 2019.07.27 Toki Messe (新潟県新潟市)

  11. Hitoshi Okazawa. Research and development of neurodegenerative diseases based on the all Japan Brain Bank Network. NEURO2019 2019.07.25 Toki Messe(Niigata)

  12. Hitoshi Okazawa. Gene therapy for spinocerebellar ataxia. The 25th Annual Meeting of Japan Society of Gene and Cell Therapy(JSGCT2019) 2019.07.21 The University of Tokyo(Tokyo)

  13. Hitoshi Okazawa. Gene therapy against SCA1 based on the molecular pathomechanism. 60th Annual Meeting Of The Japanese Society of Neurology 2019.05.25 Osaka International Convention Center(Osaka)

  14. Kyota Fujita, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Hitoshi Okazawa. Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology. 60th annual meeting of the japanese society of neurology 2019.05.22 Osaka International Convention Center(Osaka)

  15. Kyota Fujita, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Hitoshi Okazawa. Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology. 第60回日本神経学会学術大会 2019.05.22 大阪国際会議場(大阪府大阪市)

  16. Hitoshi Okazawa. New Treatment Strategies in Huntington's Disease and Other Chorea. The 6th Asian and Oceanian Parkinson's Disease and Movement Disorders Congress 2019 2019.04.13 InterContinental-Hangzhou(Hangzhou, China)

  1. Hitoshi Okazawa. Developmental YAPdeltaC determines adult pathology of spinocerebellar ataxia type 1. The 75th Fujihara Seminar 2018.12.03 Tokyo Medical and Dental University(Tokyo)

  2. Fujita Kyota, Mao Ying, Uchida Shigenori, Chen Xigui, Shiwaku Hiroki, Tamura Takuya, Ito Hikaru, Homma Hidenori, Tagawa Kazuhiko, Okazawa Hitoshi. 発達期のYAPdeltaCは脊髄小脳失調症1型モデルマウスにおける成体の病理を決定する(Developmental YAPdeltaC determines adult pathology in a mouse model of spinocerebellar ataxia type 1). 臨床神経学 2018.12.01

  3. Fujita Kyota, Mao Ying, Uchida Shigenori, Chen Xigui, Shiwaku Hiroki, Tamura Takuya, Ito Hikaru, Homma Hidenori, Tagawa Kazuhiko, Okazawa Hitoshi. 発達期のYAPdeltaCは脊髄小脳失調症1型モデルマウスにおける成体の病理を決定する(Developmental YAPdeltaC determines adult pathology in a mouse model of spinocerebellar ataxia type 1). 臨床神経学 2018.12.01

  4. 藤田慶大、陳西貴、本間秀典、田川一彦、岡澤均. アルツハイマー病と前頭側頭葉変性症に共通する異常タウリン酸化とシナプス障害. 第37回日本認知症学会学術集会 2018.10.12 ロイトン札幌・札幌市教育文化会館(北海道 札幌市)

  5. Hitoshi Okazawa. Symptomatic and Disease Modifying Treatments for Chorea and Huntington’s Disease. MDS2018 International Congress 2018.10.07 HongKong Convention and Exhibition Centre(Hong Kong, China)

  6. Hitoshi Okazawa. Comprehensive proteome analysis reveals ultra-early phase pathologies of neurodegenerative diseases. ICN 2018 Tokyo 2018.09.27 Keio Plaza Hotel(Tokyo)

  7. Hitoshi Okazawa. Novel Hippo pathway-dependent necrosis, TRIAD and Huntington’s disease. ICN 2018 Tokyo 2018.09.24 Keio Plaza Hotel(Tokyo)

  8. Seika Inoue, Kanehiro Hayashi, Kyota Fujita, Kazuhiko Tagawa, Hitoshi Okazawa, Ken-ichiro Kubo,Kazunori Nakajima. Reelin-DBNL signaling regulates neuronal migration via N-cadherin/α -N-catenin complex in the intermediate zone and multipolar cell accumulate zone of the developing mouse cerebral neocortex. The Joint Congress of the 40th Annual Meeting of Japanese Society of Biological Psychiatry and the 61st Annual Meeting of the Japanese Society for Neurochemistry 2018.09.07 Kobe Convention Center (Hyogo Kobe)

  9. Kazuhiko Tagawa, Kyota Fujita Ying Mao, Shigenori Uchida, Xigui Chen, Kei Watase, Hidenori Homma, Marius Sudol, Hitoshi Okazawa. Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1. The 41st Annual Meeting of the Japan Neuroscience Society 2018.07.28 Kobe Convention Center (Hyogo Kobe)

  10. Hikari Tanaka, Ying Mao, Takuya Tamura, Yoshie Yuki, Daisu Abe, Hidenori Homma,Kazuhiko Tagawa, Hitoshi Okazawa. The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing. The 41st Annual Meeting of the Japan Neuroscience Society 2018.07.28 Kobe Convention Center(Hyogo Kobe)

  11. 4. Hikari Tanaka, Ying Mao, Takuya Tamura, Yoshie Yuki, Daisu Abe, Hidenori Homma, Kazuhiko Tagawa, Hitoshi Okazawa. The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing. 第41回日本神経科学大会 2018.07.28

  12. Kazuhiko Tagawa, Kyota Fujita Ying Mao, Shigenori Uchida, Xigui Chen, Kei Watase, Hidenori Homma, Marius Sudol, Hitoshi Okazawa. Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1. 第41回日本神経科学大会 2018.07.28

  13. 2. 藤田 慶大、Ying Mao、陳 西貴、山西 恵美子、本間 秀典、田川 一彦、岡澤 均. ハンチントン病における新規ネクローシスTRIADの分子病態. 第41回日本神経科学大会 2018.07.28

  14. 3. Kazuhiko Tagawa, Kyota Fujita Ying Mao, Shigenori Uchida, Xigui Chen, Kei Watase, Hidenori Homma, Marius Sudol, Hitoshi Okazawa. Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1. 第41回日本神経科学大会 2018.07.28

  15. 藤田 慶大、Ying Mao、陳 西貴、山西 恵美子、本間 秀典、田川 一彦、岡澤 均 . 「ハンチントン病における新規ネクローシスTRIADの分子病態. 第41回日本神経科学大会 2018.07.28 神戸国際会議場(神戸)

  16. Kanoh Kondo, Xigui Chen, Kazumi Motoki, Hidenori Homma, Hitoshi Okazawa. In vivo imaging of intracellular organelle in neurons of Alzheimer's disease and other neurodegenerative disease model. The 41st Annual Meeting of the Japan Neuroscience Society 2018.07.27 Kobe Convention Center (Hyogo Kobe)

  17. 5. Kanoh Kondo, Xigui Chen, Kazumi Motoki, Hidenori Homma, Hitoshi Okazawa. In vivo imaging of intracellular organelle in neurons of Alzheimer's disease and other neurodegenerative disease model.. 第41回日本神経科学大会 2018.07.27

  18. Hitoshi Okazawa. Comprehensive analyses reveal new concepts of neurodegeneration in time axis. The 41st Annual Meeting of the Japanese Neuroscience Society  JNS-JSN Joint Symposium 2018.07.26 Kobe Convention Center (Hyogo Kobe)

  19. 藤田 慶大、毛 ?、内田 成則、陳 西貴、塩飽 裕紀、田村 拓也、伊藤 日加瑠、本間 秀典、田川 一彦、岡澤 均. Developmental YAPdeltaC determines adult pathology in a mouse model of spinocerebellarataxia type 1.. 第59回日本神経学会学術大会 2018.05.23

  20. 藤田 慶大、毛 瀅、内田 成則、陳 西貴、塩飽 裕紀、田村 拓也、伊藤 日加瑠、本間 秀典、田川 一彦、岡澤 均. Developmental YAPdeltaC determines adult pathology in a mouse model of spinocerebellarataxia type 1.”. 第59回日本神経学会学術大会 2018.05.23 ロイトン札幌・さっぽろ芸術文化の館・札幌市教育文化会館(札幌)

  21. 6. 藤田 慶大、毛 瀅、内田 成則、陳 西貴、塩飽 裕紀、田村 拓也、伊藤 日加瑠、本間 秀典、田川 一彦、岡澤 均. Developmental YAPdeltaC determines adult pathology in a mouse model of spinocerebellarataxia type 1.. 第59回日本神経学会学術大会 2018.05.23

  22. Hitoshi Okazawa. New Molecularly Targeted Therapeutics Deduced from Unbiased Approaches. 21st US-Japan Cellular and Gene Therapy Conference 2018.03.01 FDA White Oak Campus(Maryland, USA)

  1. Hitoshi Okazawa. Common pathologies across multiple neurodegenerative diseases revealed from unbiased approaches. 12th International Symposium of the Institute Network 2017.11.28 The Institute of Medical Science, The University Of Tokyo(Tokyo)

  2. Hitoshi Okazawa. HMGB1 and Neurodegeneration. 8th International DAMPs and Alarmins Symposium (iDEAs) 2017.11.06 Cold Spring Harbor Laboratory (NewYork, USA)

  3. Hitoshi Okazawa. Conceptual merge between aging and neurodegeneration. 16th Surugadai International Symposium & Joint Usage/Research Program of Medical Research Institute International Symposium 2017.10.11 Tokyo Medical and Dental University(Tokyo)

  4. Hitoshi Okazawa. Gene Therapy Against Spinocerebellar Ataxia. XXIII World Congress of Neurology (WCN2017) 2017.09.19 Kyoto International Conference Center (Kyoto)

  5. 7. Juliana Bosso Taniguchi, Kanoh Kondo, Kyota Fujita, Xigui Chen, Hidenori Homma, Ying Mao, Kazuhiko Tagawa, Hitoshi Okazawa. “RPA1 AMELIORATES SYMPTOMS OF MUTANT ATAXIN-1 KNOCK-IN MICE AND ENHANCE DNA DAMAGE REPAIR. RPA1 AMELIORATES SYMPTOMS OF MUTANT ATAXIN-1 KNOCK-IN MICE AND ENHANCE DNA DAMAGE REPAIR. XXIII World Congress of Neurology (WCN 2017) 合同開催:第58回日本神経学会学術大会・第23回世界神経学会議 2017.09.17

  6. 8. Kyota Fujita, Kazumi Motoki, Kazuhiko Tagawa, Xigui Chen, Hiroshi Hama, Kazuyuki Nakajima, Hidenori Homma, Takuya Tamura, Atsushi Miyawaki, Hitoshi Okazawa. HMGB1 TRIGGERS NEURITE DEGENERATION VIA TLR4-MARCKS, AND IS A POTENTIAL THERAPEUTIC TARGET FOR ALZHEIMER’S DISEASE.. XXIII World Congress of Neurology (WCN 2017) 合同開催:第58回日本神経学会学術大会・第23回世界神経学会議 2017.09.17

  7. Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology. 9. Mao Ying, Xigui Chen, Xu Min, Kyota Fujita, Kazumi Motoki, Toshikazu Sasabe, Hidenori Homma, Miho Murata, Kazuhiko Tagawa, Takuya Tamura, Kaye Julia, Steven Finkbeiner, Giovanni Blandino, Marius Sudol, Kanoh Kondo, Hitoshi Okazawa. XXIII World Congress of Neurology (WCN 2017) 合同開催:第58回日本神経学会学術大会・第23回世界神経学会議 2017.09.17

  8. Juliana Bosso Taniguchi, Kanoh Kondo, Kyota Fujita, Xigui Chen, Hidenori Homma , Ying Mao , Kazuhiko Tagawa , Hitoshi Okazawa. RPA1 AMELIORATES SYMPTOMS OF MUTANT ATAXIN-1 KNOCK-IN MICE AND ENHANCE DNA DAMAGE REPAIR. XXIII World Congress of Neurology (WCN 2017) 2017.09.17 Kyoto International Conference Center (Kyoto)

  9. Kyota Fujita, Kazumi Motoki, Kazuhiko Tagawa, Xigui Chen, Hiroshi Hama, Kazuyuki Nakajima, Hidenori Homma, Takuya Tamura, Atsushi Miyawaki, Hitoshi Okazawa. HMGB1 TRIGGERS NEURITE DEGENERATION VIA TLR4-MARCKS, AND IS A POTENTIAL THERAPEUTIC TARGET FOR ALZHEIMER’S DISEASE. XXIII World Congress of Neurology (WCN 2017) 2017.09.17 Kyoto International Conference Center (Kyoto)

  10. Hitoshi Okazawa. Common pathologies across multiple neurodegenerative diseases revealed from unbiased approaches. MyNEURO 2017 2017.08.13 Hotel Istana(KualaLumpur, Malaysia)

  11. Xigui Chen, Mao Ying, Xu Min, Kyota Fujita, Kazumi Motoki, Toshikazu Sasabe, Hidenori Homma, Miho Murata, Kazuhiko Tagawa, Takuya Tamura, Kaye Julia, Steven Finkbeiner, Giovanni Blandino, Marius Sudol, Kanoh Kondo, Hitoshi Okazawa. Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology. The 40th Annual Meeting of the Japan Neuroscience Society 2017.07.22 Kyoto International Conference Center (Kyoto)

  12. 10. Mao Ying, Xigui Chen, Xu Min, Kyota Fujita, Kazumi Motoki, Toshikazu Sasabe, Hidenori Homma, Miho Murata, Kazuhiko Tagawa, Takuya Tamura, Kaye Julia, Steven Finkbeiner, Giovanni Blandino, Marius Sudol, Kanoh Kondo, Hitoshi Okazawa. Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology. 第40回日本神経科学大会 2017.07.22

  13. Masaki Sone, Koto Furotani, Taka-aki Yajima, Takuya Tamura, Hitoshi Okazawa. Effect of specific inhibition of synaptic delivery of APP by loss-of-function of yata on the Drosophila Alzheimer's disease model. The 40th Annual Meeting of the Japan Neuroscience Society 2017.07.21 Makuhari Messe(Chiba)

  14. Juliana Bosso Taniguchi, Kanoh Kondo, Kyota Fujita, Chen Xigui, Hidenori Homma, Takeaki Sudo,Ying Mao, Kei Watase, Toshihiro Tanaka, Kazuhiko Tagawa, Takuya Tamura, Shin-Ichi Muramatsu, Hitoshi Okazawa. RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair. The 40th Annual Meeting of the Japan Neuroscience Society 2017.07.20 Makuhari Messe(Chiba)

  15. Kyota Fujita, Kazumi Motoki, Kazuhiko Tagawa, Xigui Chen, Hiroshi Hama, Kazuyuki Nakajima, Hidenori Homma, Takuya Tamura, Masahisa Katsuno, Takashi Saito, Takaomi Saido, Gen Sobue, Atsushi Miyawaki, Hitoshi Okazawa. HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease. The 40th Annual Meeting of the Japan Neuroscience Society 2017.07.20 Makuhari Messe(Chiba)

  16. 11. Kyota Fujita, Kazumi Motoki, Kazuhiko Tagawa, Xigui Chen, Hiroshi Hama, Kazuyuki Nakajima, Hidenori Homma, Takuya Tamura, Masahisa Katsuno, Takashi Saito, Takaomi Saido, Gen Sobue, Atsushi Miyawaki, Hitoshi Okazawa. HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease. 第40回日本神経科学大会 2017.07.20

  17. 12. Juliana Bosso Taniguchi, Kanoh Kondo, Kyota Fujita, Chen Xigui, Hidenori Homma, Takeaki Sudo,Ying Mao, Kei Watase, Toshihiro Tanaka, Kazuhiko Tagawa, Takuya Tamura, Shin-Ichi Muramatsu, Hitoshi Okazawa. RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair. 2017.07.20

  18. Hitoshi Okazawa. Impaired DNA Damage Repair in SCA1 and Other CAG Repeat Diseases. Gordon Research Conference - CAG Triplet Repeat Disorders 2017.06.06 Mount Snow Grand Summit Hotel (Vermont, USA)

  1. Furotani K, Yajima T, Toyokawa M, Nakayama M, Tamura T, Okazawa H, Sone M. Effect of inhibition of synaptic delivery of APP by loss-of-function of yata for the Drosophila Alzheimer's disease model. The 39th Annual Meeting of the Molecular Biology Society of Japan 2016.12.01 Rikkyo University (Tokyo)

  2. Okazawa H. Therapeutics development of Alzheimer’s disease targeting on Phase 0. 15th Surugadai International Symposium 2016.11.29 Tokyo Medical and Dental University (Tokyo)

  3. Furotani K, Yajima T, Toyokawa M, Nakayama M, Tamura T, Okazawa H, Sone M. Effect of inhibition of synaptic delivery of APP by loss-of-function of yata for the Drosophila Alzheimer's disease model. The 12th Japanese Drosophila Research Conference 2016.09.09 Rikkyo University (Tokyo)

  4. Mizuguchi M, Nabeshima Y, Obita T, Okazawa H. Interaction of spliceosomal proteins PQBP1, U5-15kD, and WBP11. The XXVIIth International Conference on Magnetic Resonance in Biological Systems 2016.08.22 International Conference Center Kyoto (Kyoto)

  5. Okazawa H. Gene therapy to conquer spinocerebellar ataxia. The 22nd Annual Meeting of Japan Society of Gene and Cell Therapy 2016.07.30 Toranomon Hills Forum (Tokyo)

  6. 13. Xigui Chen, Kanoh Kondo, Kazumi Motoki, Hidenori Homma, Hitoshi Okazawa. Fasting activates macroautophagy in neurons of Alzheimer’s disease mice but is insufficient to degrade amyloid-beta. 2016.07.21

  7. Mao Y, Tamura T, Yuki Y, Abe D, Tamada Y, Imoto S, Tanaka H, Homma H, Tagawa K, Miyano S, Okazawa H. The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing. The 39th Annual Meeting of the Japan Neuroscience Society 2016.07.20 Pacifico Yokohama (Kanagawa Yokohama)

  8. 14. Ying Mao, Takuya Tamura, Yoshie Yuki, Daisu Abe, Yoshinori Tamada, Seiya Imoto, Hikari Tanaka, Hidenori Homma, Kazuhiko Tagawa, Satoru Miyano, Hitoshi Okazawa. The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing. 第39回日本神経科学大会 2016.07.20

  9. Chen X, Kondo K, Motoki K, Homma H, Okazawa H. Fasting activates macroautophagy in neurons of AD mice but is insufficient to degrade amyloid-beta. The 57th Annual Meeting of the Japanese Society of Neurology 2016.05.19 Kobe International Exhibition Hall (Hyogo Kobe)

  10. Hikaru Ito, Kyota Fujita, Xigui Chen, Hitoshi Okazawa. Analysis of molecular mechanism and development of therapeutic methods in spinocerebellar ataxia type 1 (SCA1). 第57回日本神経学会学術大会 2016.05.18 神戸国際展示場(兵庫県神戸市)

  11. Tamura T, Shiraishi R, Sone M, Okazawa H. Systematic Analysis of Fly Models Elucidates Sleep disturbance in Huntington’s Disease. The 57th Annual Meeting of the Japanese Society of Neurology 2016.05.18 Kobe International Exhibition Hall (Hyogo Kobe)

  12. Ito H, Fujita K, Chen X, Okazawa H. Analysis of molecular mechanism and development of therapeutic methods in spinocerebellar ataxia type 1 (SCA1). The 57th Annual Meeting of the Japanese Society of Neurology 2016.05.18 Kobe International Exhibition Hall (Hyogo Kobe)

  13. Takuya Tamura, Risa Shiraishi, Masaki Sone, Hitoshi Okazawa. Systematic Analysis of Fly Models Elucidates Sleep disturbance in Huntington’s Disease. 第57回日本神経学会学術大会 2016.05.18 神戸国際展示場(兵庫県神戸市)

  1. Tagawa K, Homma H, Saito A, Murayama S, Iwatsubo T, Miyano S, Okazawa H. Comprehensive phosphoproteome analysis in preclinical Alzheimer's disease brain. The 56th Annual Meeting of the Japanese Society of Neurology 2015.05.21 TokiMesse(Niigata)

  2. Hitoshi Okazawa. In utero treatment for PQBP-1 gene mutations. The 10th International Meeting on Copy Number Variants and Genes in Intellectual Disability and Autism. 2015.04.16 La Cittadella dell'Oasi (Troina, Italy)

  1. Tamura, T., Barclay, S, S., Fujita, K., Ito, H., Motoki, K., Shimamura, T., Tagawa, K., Katsuta, A., Shiwaku, H., Sone, M., Tagawa, K., Imoto, S., Miyano, S., Okazawa, H.. Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1. Neuroscience2014 2014.09.13 Yokohama

  2. Fujita K, Nakamura Y, Oka T, Ito H, Tamura T, Tagawa K, Sasabe T, Katsuta A, Motoki K, Shiwaku H, Yoshida C, Sone M, Okazawa H. A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases.. The 37th Annual Meeting of the Japan Neuroscience Society (Neuroscience 2014) 2014.09.12 Pacifico Yokohama (Kanagawa Yokohama)

  3. Hitoshi Okazawa. Comprehensive Phosphoproteome Analysis Unravels the Core Signaling Network that Initiates the Earliest Synapse Pathology in Preclinical Alzheimer’s Disease Brain. ISP Symposium 2014 - Ageing and Metabolis 2014.08.28 東京医科歯科大学(東京)

  1. Hitoshi Okazawa. Morphological and molecular changes of synaptic spines in mouse models of PQBP1-linked intellectual disability. The 16th International Workshop on Fragile X 2013.09.17 Novotel Barossa Valley Resort (SA, Australia)

  2. Hitoshi Okazawa. Brain disease researches and brain bank. Neuro2013 Joint Conference of: The 36th annual Meeting of the Japan Neuroscience Society/ The 56th Annual Meeting of the Japanese Society for Neurochemistry/ The 23rd Annual Meeting of Japanese Neural Network Society 2013.06.22 Kyoto International Conference Center (Kyoto)

  3. Ito H, Tagawa K, Okazawa H. HMGB1 as a therapeutic molecule candidate for spinocerebellar ataxia type1 (SCA1). Neuro2013 Joint Conference of: The 36th annual Meeting of the Japan Neuroscience Society/ The 56th Annual Meeting of the Japanese Society for Neurochemistry/ The 23rd Annual Meeting of Japanese Neural Network Society 2013.06.21 Kyoto International Conference Center (Kyoto)

  4. Tamura T, Barclay SS, Fujita K, Ito H, Motoki K, Shimamura T, Tagawa K, Katsuta A, Sone M, Imoto S, Miyano S, Okazawa H. Causative pathway underlying in spinocellebelar ataxia type 1. 第36回日本神経科学大会・第56回日本神経化学会大会・第23回日本神経回路学会大会合同年会 2013.06.20 Kyoto International Conference Center(Kyoto)

  1. Hitoshi Okazawa. New Common Pathologies of Neurodegenerative Diseases. The 35th Annual Meeting ofthe Japan Neuroscience Society 2012.09.21 Nagoya Congress Center(Aichi Nagoya)

  1. Mutant alpha-synuclein propagates via the lymphatic system of the brain in the monomeric state. 2024.02.08

  1. Kyota Fujita, Ying Mao, Xigui Chen, Emiko Yamanishi, Hidenori Homma, Kazuhiko Tagawa, Hitoshi Okazawa . A novel form of necrosis, TRIAD, in Huntington's disease. The 41st Annual Meeting of the Japan Neuroscience Society 2018.07.28 Kobe Convention Center(Hyogo Kobe)

  1. Tagawa K, Homma H, Saito A, Murayama S, Iwatsubo T, Miyano S, Okazawa H. Comprehensive phosphoproteome analysis in preclinical Alzheimer's disease brain. The 38th Annual Meeting of the Japan Neuroscience Society 2015.07.30

  2. Tagawa K, Homma H, Saito A, Murayama S, Iwatsubo T, Miyano S, Okazawa H. Comprehensive phosphoproteome analysis in preclinical Alzheimer's disease brain . The 56th Annual Meeting of the Japanese Society of Neuropathology 2015.06.04

  3. Ito H, Fujita K, Tagawa K, Chen X, Homma H, Sasabe T, Shimizu J, Shimizu S, Muramatsu S, Okazawa H. HMGB1 gene therapy ameliorates phenotype of mutant ataxin-1 knock-in mice. The 56th Annual Meeting of the Japanese Society of Neurology 2015.05.21

  1. Hitoshi Okazawa. Synapse Pathology. Comprehensive Brain Science Network Winter Workshop 2014.12.13 Tokyo

  2. Hitoshi Okazawa. Present and future of research on neurological and psychiatric diseases. Comprehensive Brain Science Network Winter Workshop 2014.12.11 Tokyo Medical and Dental University

  3. Ito H, Shiwaku H, Yoshida C, Honma H, Chen X, Fujita K, Okazawa H. Mutations in the PQBP1 gene prevent its interaction with the spliceosomal protein U5-15 kD. The 37th Annual Meeting of the Molecular Biology Society of Japan 2014.11.27 Pacifico Yokohama

  4. Tamura T, Barclay S S, Fujita K, Ito H, Motoki K, Shimamura T, Tagawa K, Katsuta A, Sone M, Imoto S, Miyano, S, Okazawa H. Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1 . The 37th Annual Meeting of the Molecular Biology Society of Japan 2014.11.26 Pacifico Yokohama

  5. Hitoshi Okazawa. DNA damage repair and neurodegenerative diseases. The 37th Annual Meeting of the Molecular Biology Society of Japan 2014.11.25 Pacifico Yokohama

  6. Yajima T, Tamura T, Okazawa H, Sone M. Regulation of the intracellular trafficking of APP by the yata gene in the Drosophila model of Alzheimer's disease. The 37th Annual Meeting of the Molecular Biology Society of Japan 2014.11.25 Pacifico Yokohama

  7. Tamura T, Barclay S S, Fujita K, Ito H, Motoki K, Shimamura T, Tagawa K, Katsuta A, Shiwaku H, Sone M, Imoto S, Miyano, S, Okazawa H. Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1 . The 37th Annual Meeting of the Japan Neuroscience Society (Neuroscience 2014) 2014.09.13 Pacifico Yokohama

  8. Fujita K, Nakamura Y, Oka T, Ito H, Tamura T, Tagawa K, Sasabe T, Katsuta A, Motoki K, Shiwaku H, Yoshida C, Sone M, Okazawa H. A functional deficiency of TERA/VCP/p97 contributes to impaired DNA danage repair in multiple polyglutamine diseases. The 37th Annual Meeting of the Japan Neuroscience Society (Neuroscience 2014) 2014.09.12 Pacifico Yokohama

  9. Tamura T, Okazawa H. Systematic analysis of fly models with multiple drivers reveals different effects of ataxin-1 and huntingtin in neuron subtype-specific expression. The 7th Japan Society for Molecular Science 2014.08.25 KKR Numazu

  10. Hitoshi Okazawa. Neurodegenerative diseases and intellectual disability -RNA related molecule PQBP1 for Microcephaly. The 1st TMDU Core Seminar 2014.08.20 Tokyo Medical and Dental University

  11. Tamura T, Barclay S S, Fujita K, Ito H, Motoki K, Shimamura T, Tagawa K, Katsuta A, Sone M, Imoto S, Miyano S, Okazawa H. Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1 . The 55th Annual Meeting of the Japanese Society of Neuropathology 2014.06.06 National Center of Sciences

  12. Fujita K, Nakamura Y, Oka T, Ito H, Tamura T, Tagawa K, Sasabe T, Katsuta A, Motoki K, Shiwaku H, Yoshida C, Sone M, Okazawa H. Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1 . The 55th Annual Meeting of the Japanese Society of Neuropathology 2014.06.06 National Center of Sciences

  13. Fujita K, Nakamura Y, Oka T, Ito H, Tamura T, Tagawa K, Sasabe T, Katsuta A, Motoki K, Shiwaku H, Yoshida C, Sone M, Okazawa H. A functional deficiency of TERA/VCP/p97 contributes to impaired DNA danage repair in multiple polyglutamine diseases. The 55th Annual Meeting of the Japanese Society of Neurology 2014.05.23 Fukuoka International Congress Center

  14. Tamura T, Barclay S S, Fujita K, Ito H, Motoki K, Shimamura T, Tagawa K, Katsuta A, Sone M, Imoto S, Miyano S, Okazawa H. Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1. The 55th Annual Meeting of the Japanese Society of Neurology 2014.05.23 Fukuoka International Congress Center

  1. Tamura T, Barclay SS, Ito H, Kurosu K, Shiwaku H, Shimamura T, Tagawa K, Katsuta A, Sone M, Imoto S, Miyano S, Okazawa H. Effect of DNA damage repair genes on spinocerebellar ataxia 1:in vivo screening. The 35th Annual Meeting ofthe Japan Neuroscience Society 2012.09.19 Nagoya Congress Center

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