Department of Biodefense Research

151  articles.  
* There may be some overlapped articles listed due to the difference of format.

  1. Akiyama M, Kanayama M, Umezawa Y, Nagao T, Izumi Y, Yamamoto M, Ohteki T: An early regulatory mechanism of hyperinflammation by restricting monocyte contribution. Frontiers in immunology. 2024.07; 15 1398153. ( PubMed , DOI )

  2. Akiyama M, Kanayama M, Umezawa Y, Nagao T, Izumi Y, Yamamoto M, Ohteki T.: An early regulatory mechanism of hyperinflammation by restricting monocyte contribution Front Immunol.. 2024.07; 15 1398153.

  3. Manabu S, Nawa N, Noguchi Y, Taki A, Kashimada A, Honda I, Koyama A, Okazaki K, Kondo M, Miyahara H, Ito K, Yamauchi T, Kondo T, Honda-Ozaki F, Kusuda S, Morioka C, Fujiwara T, Morio T, Kashimada K: Stage III Chorioamnionitis Is Associated with Reduced Risk of Severe Retinopathy of Prematurity. The Journal of pediatrics. 2024.05; 114085. ( PubMed , DOI )

  4. Kamii Y, Hayashizaki K, Kanno T, Chiba A, Ikegami T, Saito M, Akeda Y, Ohteki T, Kubo M, Yoshida K, Kawakami K, Oishi K, Araya J, Kuwano K, Kronenberg M, Endo Y, Kinjo Y.: IL-27 regulates the differentiation of follicular helper NKT cells via metabolic adaptation of mitochondria. Proc Natl Acad Sci USA.. 2024.02; 121 e2313964121.

  5. Ohara D, Takeuchi Y, Watanabe H, Lee Y, Mukoyama H, Ohteki T, Kondoh G, Hirota K.: Notch2 with retinoic acid license IL-23 expression by intestinal EpCAM+ DCIR2+ cDC2s in mice J Exp Med.. 2024.02; 221 e20230923.

  6. Miyamoto T, Izawa K, Masui S, Yamazaki A, Yamasaki Y, Matsubayashi T, Shiraki M, Ohnishi H, Yasumura J, Tomohiro K, Miyamae T, Matsubara T, Arakawa N, Ishige T, Takizawa T, Shimbo A, Shimizu M, Kimura N, Maeda Y, Maruyama Y, Shigemura T, Furuta J, Sato S, Tanaka H, Izumikawa M, Yamamura M, Hasegawa T, Kaneko H, Nakagishi Y, Nakano N, Iida Y, Nakamura T, Wakiguchi H, Hoshina T, Kawai T, Murakami K, Akizuki S, Morinobu A, Ohmura K, Eguchi K, Sonoda M, Ishimura M, Furuno K, Kashiwado M, Mori M, Kawahata K, Hayama K, Shimoyama K, Sasaki N, Ito T, Umebayashi H, Omori T, Nakamichi S, Dohmoto T, Hasegawa Y, Kawashima H, Watanabe S, Taguchi Y, Nakaseko H, Iwata N, Kohno H, Ando T, Ito Y, Kataoka Y, Saeki T, Kaneko U, Murase A, Hattori S, Nozawa T, Nishimura K, Nakano R, Watanabe M, Yashiro M, Nakamura T, Komai T, Kato K, Honda Y, Hiejima E, Yonezawa A, Bessho K, Okada S, Ohara O, Takita J, Yasumi T, Nishikomori R, Japan CAPS working group: Clinical characteristics of cryopyrin-associated periodic syndrome and long-term real-world efficacy and tolerability of canakinumab in Japan: results of a nationwide survey. Arthritis & rheumatology (Hoboken, N.J.). 2024.01; ( PubMed , DOI )

  1. Shinya Abe, Takuma Asahi, Takahiro Hara, Guangwei Cui, Akihiro Shimba, Shizue Tani-Ichi, Kohei Yamada, Kazuko Miyazaki, Hitoshi Miyachi, Satsuki Kitano, Naotoshi Nakamura, Junichi Kikuta, Alexis Vandenbon, Masaki Miyazaki, Ryo Yamada, Toshiaki Ohteki, Masaru Ishii, Veronika Sexl, Takashi Nagasawa, Koichi Ikuta: Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow. Cell Rep. 2023.09; 42 (9): 113127. ( PubMed , DOI )

  2. Ziegler-Heitbrock L, Ohteki T, Ginhoux F, Shortman K, Spits H.: Reply to 'Reclassifying plasmacytoid dendritic cells as innate lymphocytes is premature'. Nat Rev Immunol. 2023.05; 23 (5): 338-339.

  3. Masashi Kanayama, Yuta Izumi, Megumi Akiyama, Toyoki Hayashi, Koji Atarashi, Axel Roers, Taku Sato, Toshiaki Ohteki: Myeloid-like B cells boost emergency myelopoiesis through IL-10 production during infection. J Exp Med. 2023.04; 220 (4): e20221221. ( PubMed , DOI )

  1. Loems Ziegler-Heitbrock, Toshiaki Ohteki, Florent Ginhoux, Ken Shortman, Hergen Spits: Reclassifying plasmacytoid dendritic cells as innate lymphocytes. Nat Rev Immunol. 2022.10; 23 (1): 1-2. ( PubMed , DOI )

  2. Guangwei Cui, Akihiro Shimba, Jianshi Jin, Taisaku Ogawa, Yukiko Muramoto, Hitoshi Miyachi, Shinya Abe, Takuma Asahi, Shizue Tani-Ichi, Johannes M Dijkstra, Yayoi Iwamoto, Kirill Kryukov, Yuanbo Zhu, Daichi Takami, Takahiro Hara, Satsuki Kitano, Yan Xu, Hajime Morita, Moyu Zhang, Lynn Zreka, Keishi Miyata, Takashi Kanaya, Shinya Okumura, Takashi Ito, Etsuro Hatano, Yoshimasa Takahashi, Hiroshi Watarai, Yuichi Oike, Tadashi Imanishi, Hiroshi Ohno, Toshiaki Ohteki, Nagahiro Minato, Masato Kubo, Georg A Holländer, Hideki Ueno, Takeshi Noda, Katsuyuki Shiroguchi, Koichi Ikuta: A circulating subset of iNKT cells mediates antitumor and antiviral immunity. Sci Immunol. 2022.10; 7 (76): eabj8760. ( PubMed , DOI )

  3. Sonn I, Honda-Ozaki F, Yoshimatsu S, Morimoto S, Watanabe H, Okano H: Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia. Inflammation and regeneration. 2022.07; 42 (1): 20. ( PubMed , DOI )

  4. Sonn Iki, Honda-Ozaki Fumiko, Yoshimatsu Sho, Morimoto Satoru, Watanabe Hirotaka, Okano Hideyuki: 一つの転写因子が高い効率でヒト人工多能性幹細胞を機能性ミクログリアに誘導する(Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia) Inflammation and Regeneration. 2022.06; 42 1 of 20-20 of 20. ( ichushi )

  1. Adachi A, Honda T, Dainichi T, Egawa G, Yamamoto Y, Nomura T, Nakajima S, Otsuka A, Maekawa M, Mano N, Koyanagi N, Kawaguchi Y, Ohteki T, Nagasawa T, Ikuta K, Kitoh A, Kabashima K.: Prolonged high-intensity exercise induces fluctuating immune responses to herpes simplex virus infection via glucocorticoids. J Allergy Clin Immunol. 2021.12;

  2. Ohteki T, Kawamura S, Onai N.: Commitment to dendritic cells and monocytes. Int Immunol.. 2021.11;

  3. Kase, N; Terashima, M; Ohta, A; Niwa, A; Honda-Ozaki, F; Kawasaki, Y; Nakahata, T; Kanazawa, N; Saito, MK: Pluripotent stem cell-based screening identifiesCUDC-907 as an effective compound for restoring the in vitro phenotype ofNakajo-Nishimurasyndrome STEM CELLS TRANSLATIONAL MEDICINE. 2021.03; 10 (3): 455-464. ( PubMed , DOI )

  4. Chikuma S, Yamanaka S, Nakagawa S, Ueda MT, Hayabuchi H, Tokifuji Y, Kanayama M, Okamura T, Arase H, Yoshimura A: TRIM28 Expression on Dendritic Cells Prevents Excessive T Cell Priming by Silencing Endogenous Retrovirus. Journal of immunology (Baltimore, Md. : 1950). 2021.02; 206 (7): 1528-1539. ( PubMed , DOI )

  5. Izumi Y, Kanayama M, Shen Z, Kai M, Kawamura S, Akiyama M, Yamamoto M, Nagao T, Okada K, Kawamata N, Toyota S, Ohteki T: An Antibody-Drug Conjugate That Selectively Targets Human Monocyte Progenitors for Anti-Cancer Therapy. Frontiers in immunology. 2021.02; 12 618081. ( PubMed , DOI )

  6. Izumi Y, Kanayama M, Shen Z, Kai M, Kawamura S, Akiyama M, Yamamoto M, Nagao T, Okada K, Kawamata N, Toyota S, Ohteki T.: An Antibody-Drug Conjugate That Selectively Targets Human Monocyte Progenitors for Anti-Cancer Therapy. Front Immunol.. 2021.02; 12 618081..

  1. Kana Minamide, Taku Sato, Yusuke Nakanishi, Hiroshi Ohno, Tamotsu Kato, Jumpei Asano, Toshiaki Ohteki: IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon. Sci Rep. 2020.09; 10 (1): 14639. ( PubMed , DOI )

  2. Kanayama M, Izumi Y, Yamauchi Y, Kuroda S, Shin T, Ishikawa S, Sato T, Kajita M, Ohteki T.: CD86-based analysis enables observation of bona fide hematopoietic responses Blood.. 2020.09; 136 (10): 1144-1154.

  3. Sato T, Ishikawa S, Asano J, Yamamoto H, Fujii M, Sato T, Yamamoto K, Kitagaki K, Akashi T, Okamoto R, Ohteki T.: Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages. Nat Cell Biol. . 2020.08; 22 (8): 919-926.

  4. Liang J, Zhang JJ, Huang HI, Kanayama M, Youssef N, Jin YJ, Reyes EY, Abram CL, Yang S, Lowell CA, Wang D, Shao L, Shinohara ML, Zhang JY, Hammer GE: The ubiquitin-modifying enzyme A20 terminates C-type lectin receptor signals and is a suppressor of host defense against systemic fungal infection. Infection and immunity. 2020.06; 88 (9): ( PubMed , DOI )

  5. Kanayama M, Izumi Y, Yamauchi Y, Kuroda S, Shin T, Ishikawa S, Sato T, Kajita M, Ohteki T: CD86-based analysis enables observation of bona fide hematopoietic responses. Blood. 2020.05; ( PubMed , DOI )

  6. Taku Sato, Miwako Sase, Shun Ishikawa, Mihoko Kajita, Jumpei Asano, Toshiro Sato, Yoshiyuki Mori, Toshiaki Ohteki: Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine. Sci Rep. 2020.05; 10 (1): 8308. ( PubMed , DOI )

  7. 泉 湧太, 金山 剛士, 秋山 めぐみ, 甲斐 正之, 沈 鐘楚子, 川又 紀彦, 樗木 俊聡: Targeting monocyte lineage-restricted antigen as a novel therapeutic strategy for monocytic leukemia(和訳中) 日本病理学会会誌. 2020.03; 109 (1): 304. ( ichushi )

  8. Jumpei Asano, Taku Sato, Toshiaki Ohteki: Autophagy Detection in Intestinal Stem Cells. Methods Mol Biol. 2020; 2171 115-125. ( PubMed , DOI )

  1. Kanayama Masashi, Izumi Yuta, Ohteki Toshiaki: Hematopoiesis and Immune Environment　Analysis with an alternative marker for Sca-1 revealed bona fide hematopoietic responses during infection(和訳中) 日本免疫学会総会・学術集会記録. 2019.11; 48 (Proceedings): 1-H. ( ichushi )

  2. Kunimoto Kayo, Honda-Ozaki Fumiko, Saito Megumu K., Furukawa Fukumi, Kanazawa Nobuo: 中條・西村症候群の小児症例に対するメトトレキサートの有益な作用(Beneficial effect of methotrexate on a child case of Nakajo-Nishimura syndrome) The Journal of Dermatology. 2019.10; 46 (10): e365-e367. ( ichushi )

  3. Hiroyuki Tezuka, Toshiaki Ohteki: Regulation of IgA Production by Intestinal Dendritic Cells and Related Cells. Front Immunol. 2019.08; 10 1891. ( PubMed , DOI )

  4. Kanazawa Nobuo, Honda-Ozaki Fumiko, Saito Megumu K.: 中條-西村症候群を再現した人工多能性幹細胞(Induced pluripotent stem cells representing Nakajo-Nishimura syndrome) Inflammation and Regeneration. 2019.05; 39 1 of 8-8 of 8. ( ichushi )

  5. Zi Wang, Soichiro Adachi, Lingling Kong, Daisuke Watanabe, Yusuke Nakanishi, Toshiaki Ohteki, Namiko Hoshi, Yuzo Kodama: Role of eosinophils in a murine model of inflammatory bowel disease. Biochem. Biophys. Res. Commun.. 2019.03; 511 (1): 99-104. ( PubMed , DOI )

  6. Adachi Takahiro, Yoshikawa Soichiro, Tezuka Hiroyuki, Tsuji Noriko M., Ohteki Toshiaki, Karasuyama Hajime, Kumazawa Toshihiko: Propolis induces Ca2+ signaling in immune cells BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH. 2019; 38 (4): 141-149. ( DOI )

  1. Shunsuke Kawamura, Toshiaki Ohteki: Monopoiesis in humans and mice. Int. Immunol.. 2018.10; 30 (11): 503-509. ( PubMed , DOI )

  2. Honda-Ozaki F, Terashima M, Niwa A, Saiki N, Kawasaki Y, Ito H, Hotta A, Nagahashi A, Igura K, Asaka I, Li HL, Yanagimachi M, Furukawa F, Kanazawa N, Nakahata T, Saito MK: Pluripotent Stem Cell Model of Nakajo-Nishimura Syndrome Untangles Proinflammatory Pathways Mediated by Oxidative Stress. Stem cell reports. 2018.06; 10 (6): 1835-1850. ( PubMed , DOI )

  3. Y Nakanishi, T Sato, K Takahashi, T Ohteki: IFN-γ-dependent epigenetic regulation instructs colitogenic monocyte/macrophage lineage differentiation in vivo. Mucosal Immunol. 2018.05; 11 (3): 871-880. ( PubMed , DOI )

  1. Kanayama Masashi, Xu Shengjie, Gibson Jason R, Inoue Makoto, Gregory Simon G, Shinohara Mari L: Hematopoiesis and immune environments Balancing population sizes of myeloid and lymphoid cells by osteopontin isoforms(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 1-G. ( ichushi )

  2. Kanayama Masashi, Xu Shengjie, Danzaki Keiko, Gibson Jason R., Inoue Makoto, Gregory Simon G., Shinohara Mari L.: Skewing the population balance between lymphoid and myeloid cells by osteopontin isoforms CYTOKINE. 2017.12; 100 161.

  3. Nobuyuki Onai, Jumpei Asano, Rumiko Kurosaki, Shoko Kuroda, Toshiaki Ohteki: Flexible fate commitment of E2-2high common DC progenitors implies tuning in tissue microenvironments. Int. Immunol.. 2017.12; 29 (10): 443-456. ( PubMed , DOI )

  4. Nadya NA, Tezuka H, Ohteki T, Matsuda S, Azuma M, Nagai S: PI3K-Akt pathway enhances the differentiation of interleukin-27-induced type 1 regulatory T cells. Immunology. 2017.11; 152 (3): 507-516. ( PubMed , DOI )

  5. Kenshiro Matsuda, Noriko Okamoto, Masatoshi Kondo, Peter D Arkwright, Kaoru Karasawa, Saori Ishizaka, Shinichi Yokota, Akira Matsuda, Kyungsook Jung, Kumiko Oida, Yosuke Amagai, Hyosun Jang, Eiichiro Noda, Ryota Kakinuma, Koujirou Yasui, Uiko Kaku, Yasuo Mori, Nobuyuki Onai, Toshiaki Ohteki, Akane Tanaka, Hiroshi Matsuda: Mast cell hyperactivity underpins the development of oxygen-induced retinopathy. J. Clin. Invest.. 2017.11; 127 (11): 3987-4000. ( PubMed , DOI )

  6. Jumpei Asano, Taku Sato, Shizuko Ichinose, Mihoko Kajita, Nobuyuki Onai, Shigeomi Shimizu, Toshiaki Ohteki: Intrinsic Autophagy Is Required for the Maintenance of Intestinal Stem Cells and for Irradiation-Induced Intestinal Regeneration. Cell Rep. 2017.08; 20 (5): 1050-1060. ( PubMed , DOI )

  7. Masashi Kanayama, Shengjie Xu, Keiko Danzaki, Jason R Gibson, Makoto Inoue, Simon G Gregory, Mari L Shinohara: Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin. Nature Immunology. 2017.07; ( PubMed , DOI )

  8. Shunsuke Kawamura, Nobuyuki Onai, Fuyuki Miya, Taku Sato, Tatsuhiko Tsunoda, Kazutaka Kurabayashi, Satoshi Yotsumoto, Shoko Kuroda, Katsuto Takenaka, Koichi Akashi, Toshiaki Ohteki: Identification of a Human Clonogenic Progenitor with Strict Monocyte Differentiation Potential: A Counterpart of Mouse cMoPs. Immunity. 2017.05; 46 (5): 835-848.e4. ( PubMed , DOI )

  1. Takayuki Yokoi, Kentarou Yokoi, Kazumasa Akiyama, Takashi Higuchi, Yohta Shimada, Hiroshi Kobayashi, Taku Sato, Toshiaki Ohteki, Makoto Otsu, Hiromitsu Nakauchi, Hiroyuki Ida, Toya Ohashi: Non-myeloablative preconditioning with ACK2 (anti-c-kit antibody) is efficient in bone marrow transplantation for murine models of mucopolysaccharidosis type II. Mol. Genet. Metab.. 2016.11; 119 (3): 232-238. ( PubMed , DOI )

  2. Keiko Danzaki, Masashi Kanayama, Oscar Alcazar, Mari L Shinohara: Osteopontin has a protective role in prostate tumor development in mice. European journal of immunology. 2016.11; 46 (11): 2669-2678. ( PubMed , DOI )

  3. Masashi Kanayama, Keiko Danzaki, You-Wen He, Mari L Shinohara: Lung inflammation stalls Th17-cell migration en route to the central nervous system during the development of experimental autoimmune encephalomyelitis. Int. Immunol.. 2016.09; 28 (9): 463-469. ( PubMed , DOI )

  4. Jiajia Liu, Yong-Mei Guo, Nobuyuki Onai, Hideaki Ohyagi, Makoto Hirokawa, Naoto Takahashi, Hiroyuki Tagawa, Kumi Ubukawa, Isuzu Kobayashi, Hiroyuki Tezuka, Yoshihiro Minamiya, Toshiaki Ohteki, Kenichi Sawada: Cytosine-Phosphorothionate-Guanine Oligodeoxynucleotides Exacerbates Hemophagocytosis by Inducing Tumor Necrosis Factor-Alpha Production in Mice after Bone Marrow Transplantation. Biol Blood Marrow Transplant. 2016.04; 22 (4): 627-636. ( PubMed , DOI )

  5. Masashi Kanayama, Mari L Shinohara: Roles of Autophagy and Autophagy-Related Proteins in Antifungal Immunity. Front Immunol. 2016.02; 7 47. ( PubMed , DOI )

  6. Nobuyuki Onai, Toshiaki Ohteki: Isolation of Dendritic Cell Progenitor and Bone Marrow Progenitor Cells from Mouse. Methods Mol. Biol.. 2016.01; 1423 53-59. ( PubMed , DOI )

  1. Tsutomu Endo, Koyu Ito, Junko Morimoto, Masashi Kanayama, Daichi Ota, Masahiro Ikesue, Shigeyuki Kon, Daisuke Takahashi, Tomohiro Onodera, Norimasa Iwasaki, Toshimitsu Uede: Syndecan 4 Regulation of the Development of Autoimmune Arthritis in Mice by Modulating B Cell Migration and Germinal Center Formation. Arthritis & rheumatology (Hoboken, N.J.). 2015.09; 67 (9): 2512-2522. ( PubMed , DOI )

  2. Masashi Kanayama, You-Wen He, Mari L Shinohara: The lung is protected from spontaneous inflammation by autophagy in myeloid cells. J. Immunol.. 2015.06; 194 (11): 5465-5471. ( PubMed , DOI )

  3. Hiroshi Kobayashi, Chiharu I Kobayashi, Ayako Nakamura-Ishizu, Daiki Karigane, Hiroshi Haeno, Kimiyo N Yamamoto, Taku Sato, Toshiaki Ohteki, Yoshihiro Hayakawa, Glen N Barber, Mineo Kurokawa, Toshio Suda, Keiyo Takubo: Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING. Cell Rep. 2015.04; 11 (1): 71-84. ( PubMed , DOI )

  4. Y Nakanishi, T Sato, T Ohteki: Commensal Gram-positive bacteria initiates colitis by inducing monocyte/macrophage mobilization. Mucosal Immunol. 2015.01; 8 (1): 152-160. ( PubMed , DOI )

  5. Masashi Kanayama, Makoto Inoue, Keiko Danzaki, Gianna Hammer, You-Wen He, Mari L Shinohara: Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. Nature Communications. 2015.01; 6 5779. ( PubMed , DOI )

  1. Daichi Ota, Masashi Kanayama, Yutaka Matsui, Koyu Ito, Naoyoshi Maeda, Goro Kutomi, Koichi Hirata, Toshihiko Torigoe, Noriyuki Sato, Akinori Takaoka, Ann F Chambers, Junko Morimoto, Toshimitsu Uede: Tumor-α9β1 integrin-mediated signaling induces breast cancer growth and lymphatic metastasis via the recruitment of cancer-associated fibroblasts. J. Mol. Med.. 2014.12; 92 (12): 1271-1281. ( PubMed , DOI )

  2. Shigeyuki Kon, Yosuke Nakayama, Naoki Matsumoto, Koyu Ito, Masashi Kanayama, Chiemi Kimura, Hitomi Kouro, Dai Ashitomi, Tadashi Matsuda, Toshimitsu Uede: A novel cryptic binding motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved osteopontin as a novel ligand for α9β1 integrin is involved in the anti-type II collagen antibody-induced arthritis. PLoS ONE. 2014.12; 9 (12): e116210. ( PubMed , DOI )

  3. Nobuyuki Onai, Toshiaki Ohteki: Bipotent or Oligopotent? A Macrophage and DC Progenitor Revisited. Immunity. 2014.07; 41 (1): 5-7. ( PubMed , DOI )

  4. A Yokota-Nakatsuma, H Takeuchi, Y Ohoka, C Kato, S-Y Song, T Hoshino, H Yagita, T Ohteki, M Iwata: Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells. Mucosal Immunol. 2014.07; 7 (4): 786-801. ( PubMed , DOI )

  5. Tsuyoshi Asano, Norimasa Iwasaki, Shigeyuki Kon, Masashi Kanayama, Junko Morimoto, Akio Minami, Toshimitsu Uede: α9β1 integrin acts as a critical intrinsic regulator of human rheumatoid arthritis. Rheumatology (Oxford). 2014.03; 53 (3): 415-424. ( PubMed , DOI )

  1. Takayuki Sato, Toshio Kitawaki, Haruyuki Fujita, Makoto Iwata, Tomonori Iyoda, Kayo Inaba, Toshiaki Ohteki, Suguru Hasegawa, Kenji Kawada, Yoshiharu Sakai, Hiroki Ikeuchi, Hiroshi Nakase, Akira Niwa, Akifumi Takaori-Kondo, Norimitsu Kadowaki: Human CD1c⁺ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D₃. J Immunol. 2013.09; 191 (6): 3152-3160. ( PubMed , DOI )

  2. Hideaki Ohyagi, Nobuyuki Onai, Taku Sato, Satoshi Yotsumoto, Jiajia Liu, Hisaya Akiba, Hideo Yagita, Koji Atarashi, Kenya Honda, Axel Roers, Werner Müller, Kazutaka Kurabayashi, Mayuka Hosoi-Amaike, Naoto Takahashi, Makoto Hirokawa, Kouji Matsushima, Kenichi Sawada, Toshiaki Ohteki: Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses. Immunity. 2013.09; 39 (3): 584-598. ( PubMed , DOI )

  3. Atsushi Hayashi, Toshiro Sato, Nobuhiko Kamada, Yohei Mikami, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Toshifumi Hibi, Axel Roers, Hideo Yagita, Toshiaki Ohteki, Akihiko Yoshimura, Takanori Kanai: A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice. Cell Host Microbe. 2013.06; 13 (6): 711-722. ( PubMed , DOI )

  4. Nobuyuki Onai, Kazutaka Kurabayashi, Mayuka Hosoi-Amaike, Noriko Toyama-Sorimachi, Kouji Matsushima, Kayo Inaba, Toshiaki Ohteki: A clonogenic progenitor with prominent plasmacytoid dendritic cell developmental potential. Immunity. 2013.05; 38 (5): 943-957. ( PubMed , DOI )

  5. Taku Sato, Mahoko Ikeda, Satoshi Yotsumoto, Yohta Shimada, Takashi Higuchi, Hiroshi Kobayashi, Takahiro Fukuda, Toya Ohashi, Toshio Suda, Toshiaki Ohteki: Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder. Blood. 2013.04; 121 (16): 3267-3273. ( PubMed , DOI )

  6. Akihiko Ichikawa, Keiji Kuba, Masayuki Morita, Shinsuke Chida, Hiroyuki Tezuka, Hiromitsu Hara, Takehiko Sasaki, Toshiaki Ohteki, V Marco Ranieri, Claudia C dos Santos, Yoshihiro Kawaoka, Shizuo Akira, Andrew D Luster, Bao Lu, Josef M Penninger, Stefan Uhlig, Arthur S Slutsky, Yumiko Imai: CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am J Respir Crit Care Med. 2013.01; 187 (1): 65-77. ( PubMed , DOI )

  1. Jiajia Liu, Yong-Mei Guo, Makoto Hirokawa, Keiko Iwamoto, Kumi Ubukawa, Yoshihiro Michishita, Naohito Fujishima, Hiroyuki Tagawa, Naoto Takahashi, Weiguo Xiao, Junsuke Yamashita, Toshiaki Ohteki, Kenichi Sawada: A synthetic double-stranded RNA, poly I:C, induces a rapid apoptosis of human CD34(+) cells. Exp Hematol. 2012.04; 40 (4): 330-341. ( PubMed , DOI )

  2. Keiko Danzaki, Yutaka Matsui, Masahiro Ikesue, Daichi Ohta, Koyu Ito, Masashi Kanayama, Daisuke Kurotaki, Junko Morimoto, Yoichiro Iwakura, Hideo Yagita, Hiroyuki Tsutsui, Toshimitsu Uede: Interleukin-17A deficiency accelerates unstable atherosclerotic plaque formation in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol.. 2012.02; 32 (2): 273-280. ( PubMed , DOI )

  3. Yukinori Tsukuda, Norimasa Iwasaki, Naoki Seito, Masashi Kanayama, Naoki Fujitani, Yasuro Shinohara, Yasuhiko Kasahara, Tomohiro Onodera, Koji Suzuki, Tsuyoshi Asano, Akio Minami, Tadashi Yamashita: Ganglioside GM3 has an essential role in the pathogenesis and progression of rheumatoid arthritis. PLoS ONE. 2012.01; 7 (6): e40136. ( PubMed , DOI )

  1. Masashi Kanayama, Junko Morimoto, Yutaka Matsui, Masahiro Ikesue, Keiko Danzaki, Daisuke Kurotaki, Koyu Ito, Toshimichi Yoshida, Toshimitsu Uede: α9β1 integrin-mediated signaling serves as an intrinsic regulator of pathogenic Th17 cell generation. J. Immunol.. 2011.12; 187 (11): 5851-5864. ( PubMed , DOI )

  2. Hirosato Mashima, Taku Sato, Yasuo Horie, Yuko Nakagawa, Itaru Kojima, Toshiaki Ohteki, Hirohide Ohnishi: Interferon regulatory factor-2 regulates exocytosis mechanisms mediated by SNAREs in pancreatic acinar cells. Gastroenterology. 2011.09; 141 (3): 1102-1113.e1. ( PubMed , DOI )

  3. 樗木俊聡: 腸管粘膜における樹状細胞の役割(The Role of dendritic cells in the intestinal mucosa) 日本耳鼻咽喉科学会会報　114. 2011.06; 107-113.

  4. Daisuke Kurotaki, Shigeyuki Kon, Kyeonghwa Bae, Koyu Ito, Yutaka Matsui, Yosuke Nakayama, Masashi Kanayama, Chiemi Kimura, Yoshinori Narita, Takashi Nishimura, Kazuya Iwabuchi, Matthias Mack, Nico van Rooijen, Shimon Sakaguchi, Toshimitsu Uede, Junko Morimoto: CSF-1-dependent red pulp macrophages regulate CD4 T cell responses. J. Immunol.. 2011.02; 186 (4): 2229-2237. ( PubMed , DOI )

  5. Hiroyuki Tezuka, Yukiko Abe, Jumpei Asano, Taku Sato, Jiajia Liu, Makoto Iwata, Toshiaki Ohteki: Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction. Immunity. 2011.02; 34 (2): 247-257. ( PubMed , DOI )

  1. Yoshitake Kanazawa, Yasuyuki Saito, Yana Supriatna, Hiroyuki Tezuka, Takenori Kotani, Yoji Murata, Hideki Okazawa, Hiroshi Ohnishi, Yoshitaka Kinouchi, Yoshihisa Nojima, Toshiaki Ohteki, Tooru Shimosegawa, Takashi Matozaki: Role of SIRPα in regulation of mucosal immunity in the intestine. Genes Cells. 2010.12; 15 (12): 1189-1200. ( PubMed , DOI )

  2. Hiroyuki Tezuka, Toshiaki Ohteki: A gas governing mucosal immunity. Vaccine. 2010.11; 28 (50): 8039-8040. ( PubMed , DOI )

  3. Yong-Mei Guo, Keiko Ishii, Makoto Hirokawa, Hiroyuki Tagawa, Hideaki Ohyagi, Yoshihiro Michishita, Kumi Ubukawa, Junsuke Yamashita, Toshiaki Ohteki, Nobuyuki Onai, Kazuyoshi Kawakami, Weiguo Xiao, Kenichi Sawada: CpG-ODN 2006 and human parvovirus B19 genome consensus sequences selectively inhibit growth and development of erythroid progenitor cells. Blood. 2010.06; 115 (22): 4569-4579. ( PubMed , DOI )

  4. Hiroyuki Tezuka, Toshiaki Ohteki: Regulation of intestinal homeostasis by dendritic cells. Immunol Rev. 2010.03; 234 (1): 247-258. ( PubMed , DOI )

  5. Jumpei Asano, Hiroyuki Tada, Nobuyuki Onai, Taku Sato, Yasuo Horie, Yukari Fujimoto, Koichi Fukase, Akira Suzuki, Tak W Mak, Toshiaki Ohteki: Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo. J Immunol. 2010.01; 184 (2): 736-745. ( PubMed , DOI )

  1. Takayuki Tomita, Takanori Kanai, Teruji Totsuka, Yasuhiro Nemoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Naoya Sakamoto, Toshiaki Ohteki, Toshifumi Hibi, Mamoru Watanabe: IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis. Eur J Immunol. 2009.10; 39 (10): 2737-2747. ( PubMed , DOI )

  2. Masashi Kanayama, Daisuke Kurotaki, Junko Morimoto, Tsuyoshi Asano, Yutaka Matsui, Yosuke Nakayama, Yoshinari Saito, Koyu Ito, Chiemi Kimura, Norimasa Iwasaki, Koji Suzuki, Tanenobu Harada, Hong Mei Li, Jun Uehara, Tadaaki Miyazaki, Akio Minami, Shigeyuki Kon, Toshimitsu Uede: Alpha9 integrin and its ligands constitute critical joint microenvironments for development of autoimmune arthritis. J. Immunol.. 2009.06; 182 (12): 8015-8025. ( PubMed , DOI )

  3. Taku Sato, Nobuyuki Onai, Hiroki Yoshihara, Fumio Arai, Toshio Suda, Toshiaki Ohteki: Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. Nat Med. 2009.06; 15 (6): 696-700. ( PubMed , DOI )

  4. Jun Yamada, Junji Hamuro, Atsuki Fukushima, Toshiaki Ohteki, Kazuto Terai, Yoichiro Iwakura, Hideo Yagita, Shigeru Kinoshita: MHC-matched corneal allograft rejection in an IFN-gamma/IL-17-independent manner in C57BL/6 mice. Invest Ophthalmol Vis Sci. 2009.05; 50 (5): 2139-2146. ( PubMed , DOI )

  5. Koyu Ito, Shigeyuki Kon, Yosuke Nakayama, Daisuke Kurotaki, Yoshinari Saito, Masashi Kanayama, Chiemi Kimura, Hongyan Diao, Junko Morimoto, Yutaka Matsui, Toshimitsu Uede: The differential amino acid requirement within osteopontin in alpha4 and alpha9 integrin-mediated cell binding and migration. Matrix Biol.. 2009.01; 28 (1): 11-19. ( PubMed , DOI )

  1. Fumi Miyagawa, Yutaka Tagaya, Brian S Kim, Hiral J Patel, Kazuto Ishida, Toshiaki Ohteki, Thomas A Waldmann, Stephen I Katz: IL-15 serves as a costimulator in determining the activity of autoreactive CD8 T cells in an experimental mouse model of graft-versus-host-like disease. J Immunol. 2008.07; 181 (2): 1109-1119. ( PubMed )

  2. Shoko Kuroda, Miki Nishio, Takehiko Sasaki, Yasuo Horie, Koichi Kawahara, Masato Sasaki, Miyuki Natsui, Takashi Matozaki, Hiroyuki Tezuka, Toshiaki Ohteki, Irmgard Förster, Tak W Mak, Toru Nakano, Akira Suzuki: Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages. Eur J Immunol. 2008.05; 38 (5): 1331-1340. ( PubMed , DOI )

  3. Magali Terme, Nathalie Chaput, Behazine Combadiere, Averil Ma, Toshiaki Ohteki, Laurence Zitvogel: Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells. J Immunol. 2008.04; 180 (7): 4679-4686. ( PubMed )

  1. Yoshinari Saito, Shigeyuki Kon, Yukio Fujiwara, Yosuke Nakayama, Daisuke Kurotaki, Naoki Fukuda, Chiemi Kimura, Masashi Kanayama, Koyu Ito, Hongyan Diao, Yutaka Matsui, Yasuo Komatsu, Eiko Ohtsuka, Toshimitsu Uede: Osteopontin small interfering RNA protects mice from fulminant hepatitis. Hum. Gene Ther.. 2007.12; 18 (12): 1205-1214. ( PubMed , DOI )

  2. Nobuyuki Onai, Aya Obata-Onai, Michael A Schmid, Toshiaki Ohteki, David Jarrossay, Markus G Manz: Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol. 2007.11; 8 (11): 1207-1216. ( PubMed , DOI )

  3. Toshiaki Ohteki: The dynamics of dendritic cell: mediated innate immune regulation. Allergol Int. 2007.09; 56 (3): 209-214. ( PubMed , DOI )

  4. Hiroyuki Tezuka, Yukiko Abe, Makoto Iwata, Hajime Takeuchi, Hiromichi Ishikawa, Masayuki Matsushita, Tetsuo Shiohara, Shizuo Akira, Toshiaki Ohteki: Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells. Nature. 2007.08; 448 (7156): 929-933. ( PubMed , DOI )

  5. Hiroyuki Kishimoto, Toshiaki Ohteki, Nobuyuki Yajima, Koichi Kawahara, Miyuki Natsui, Satoru Kawarasaki, Koichi Hamada, Yasuo Horie, Yoshiaki Kubo, Seiji Arase, Masaru Taniguchi, Bart Vanhaesebroeck, Tak Wah Mak, Toru Nakano, Shigeo Koyasu, Takehiko Sasaki, Akira Suzuki: The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells. Blood. 2007.04; 109 (8): 3316-3324. ( PubMed , DOI )

  1. Toshiaki Ohteki, Hiroyuki Tada, Kazuto Ishida, Taku Sato, Chikako Maki, Taketo Yamada, Junji Hamuro, Shigeo Koyasu: Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo. J Exp Med. 2006.10; 203 (10): 2329-2338. ( PubMed , DOI )

  2. Seiichi Kuwajima, Taku Sato, Kazuto Ishida, Hiroyuki Tada, Hiroyuki Tezuka, Toshiaki Ohteki: Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation. Nat Immunol. 2006.07; 7 (7): 740-746. ( PubMed , DOI )

  3. Noriko Kitanaka, Yuji Owada, Ryuhei Okuyama, Hiroyuki Sakagami, Mohammad Reza Nourani, Setsuya Aiba, Hiroshi Furukawa, Makoto Watanabe, Masao Ono, Toshiaki Ohteki, Hisatake Kondo: Epidermal-type fatty acid binding protein as a negative regulator of IL-12 production in dendritic cells. Biochem Biophys Res Commun. 2006.06; 345 (1): 459-466. ( PubMed , DOI )

  1. Hiroyuki Tada, Setsuya Aiba, Ken-Ichiro Shibata, Toshiaki Ohteki, Haruhiko Takada: Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells. Infect Immun. 2005.12; 73 (12): 7967-7976. ( PubMed , DOI )

  1. Kenya Honda, Shinya Sakaguchi, Chigusa Nakajima, Ai Watanabe, Hideyuki Yanai, Misako Matsumoto, Toshiaki Ohteki, Tsuneyasu Kaisho, Akinori Takaoka, Shizuo Akira, Tsukasa Seya, Tadatsugu Taniguchi: Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc Natl Acad Sci USA. 2003.09; 100 (19): 10872-10877. ( PubMed , DOI )

  2. Kaisa Holmberg, Sanjeev Mariathasan, Toshiaki Ohteki, Pamela S Ohashi, Nicholas R J Gascoigne: TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCR. J Immunol. 2003.09; 171 (5): 2427-2434. ( PubMed )

  3. Toshimasa Yamauchi, Junji Kamon, Yusuke Ito, Atsushi Tsuchida, Takehiko Yokomizo, Shunbun Kita, Takuya Sugiyama, Makoto Miyagishi, Kazuo Hara, Masaki Tsunoda, Koji Murakami, Toshiaki Ohteki, Shoko Uchida, Sato Takekawa, Hironori Waki, Nelson H Tsuno, Yoichi Shibata, Yasuo Terauchi, Philippe Froguel, Kazuyuki Tobe, Shigeo Koyasu, Kazunari Taira, Toshio Kitamura, Takao Shimizu, Ryozo Nagai, Takashi Kadowaki: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003.06; 423 (6941): 762-769. ( PubMed , DOI )

  4. Harumi Suzuki, Satoshi Matsuda, Yasuo Terauchi, Mari Fujiwara, Toshiaki Ohteki, Tomoichiro Asano, Timothy W Behrens, Taku Kouro, Kiyoshi Takatsu, Takashi Kadowaki, Shigeo Koyasu: PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction. Nat Immunol. 2003.03; 4 (3): 280-286. ( PubMed , DOI )

  5. Samuel D Saibil, Toshiaki Ohteki, Forest M White, Mark Luscher, Arsen Zakarian, Alisha Elford, Jeffery Shabanowitz, Hiroshi Nishina, Patrice Hugo, Josef Penninger, Brian Barber, Donald F Hunt, Pamela S Ohashi: Weak agonist self-peptides promote selection and tuning of virus-specific T cells. Eur J Immunol. 2003.03; 33 (3): 685-696. ( PubMed , DOI )

  1. Yukie Murata, Toshiaki Ohteki, Shigeo Koyasu, Junji Hamuro: IFN-gamma and pro-inflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension. Eur J Immunol. 2002.10; 32 (10): 2866-2873. ( PubMed , DOI )

  2. Toshiaki Ohteki: Critical role for IL-15 in innate immunity. Curr Mol Med. 2002.06; 2 (4): 371-380. ( PubMed )

  3. Kristine M Garza, Kim J McKall-Faienza, Toshiaki Otheki, Arsen Zakarian, Bernhard Odermatt, Pamela S Ohashi: Enhanced T cell responses contribute to the genetic predisposition of CD8-mediated spontaneous autoimmunity. Eur J Immunol. 2002.03; 32 (3): 885-894. ( PubMed , DOI )

  1. T Ohteki, K Suzue, C Maki, T Ota, S Koyasu: Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response. Nat Immunol. 2001.12; 2 (12): 1138-1143. ( PubMed , DOI )

  2. T Ohteki, C Maki, S Koyasu: Overexpression of Bcl-2 differentially restores development of thymus-derived CD4-8+ T cells and intestinal intraepithelial T cells in IFN-regulatory factor-1-deficient mice. J Immunol. 2001.06; 166 (11): 6509-6513. ( PubMed )

  3. A Suzuki, M T Yamaguchi, T Ohteki, T Sasaki, T Kaisho, Y Kimura, R Yoshida, A Wakeham, T Higuchi, M Fukumoto, T Tsubata, P S Ohashi, S Koyasu, J M Penninger, T Nakano, T W Mak: T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity. 2001.05; 14 (5): 523-534. ( PubMed )

  4. T Ohteki, S Koyasu: Role of antigen-presenting cells in innate immune system. Arch Immunol Ther Exp (Warsz.). 2001.01; 49 Suppl 1 S47-S52. ( PubMed )

  1. T Ohteki, M Parsons, A Zakarian, R G Jones, L T Nguyen, J R Woodgett, P S Ohashi: Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3. J Exp Med. 2000.07; 192 (1): 99-104. ( PubMed )

  1. T Ohteki, A Hessel, M F Bachmann, A Zakarian, E Sebzda, M S Tsao, K McKall-Faienza, B Odermatt, P S Ohashi: Identification of a cross-reactive self ligand in virus-mediated autoimmunity. Eur J Immunol. 1999.09; 29 (9): 2886-2896. ( PubMed , DOI )

  2. T Ohteki, T Fukao, K Suzue, C Maki, M Ito, M Nakamura, S Koyasu: Interleukin 12-dependent interferon gamma production by CD8alpha+ lymphoid dendritic cells. J Exp Med. 1999.06; 189 (12): 1981-1986. ( PubMed )

  3. T Ohteki, C Maki, S Koyasu, T W Mak, P S Ohashi: Cutting edge: LFA-1 is required for liver NK1.1+TCR alpha beta+ cell development: evidence that liver NK1.1+TCR alpha beta+ cells originate from multiple pathways. J Immunol. 1999.04; 162 (7): 3753-3756. ( PubMed )

  4. E Sebzda, S Mariathasan, T Ohteki, R Jones, M F Bachmann, P S Ohashi: Selection of the T cell repertoire. Annu Rev Immunol. 1999.01; 17 829-874. ( PubMed , DOI )

  1. S Mariathasan, M F Bachmann, D Bouchard, T Ohteki, P S Ohashi: Degree of TCR internalization and Ca2+ flux correlates with thymocyte selection. J Immunol. 1998.12; 161 (11): 6030-6037. ( PubMed )

  2. T Ohteki, H Yoshida, T Matsuyama, G S Duncan, T W Mak, P S Ohashi: The transcription factor interferon regulatory factor 1 (IRF-1) is important during the maturation of natural killer 1.1+ T cell receptor-alpha/beta+ (NK1+ T) cells, natural killer cells, and intestinal intraepithelial T cells. J Exp Med. 1998.03; 187 (6): 967-972. ( PubMed )

  3. H Yoshida, H Nishina, H Takimoto, L E Marengère, A C Wakeham, D Bouchard, Y Y Kong, T Ohteki, A Shahinian, M Bachmann, P S Ohashi, J M Penninger, G R Crabtree, T W Mak: The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity. 1998.01; 8 (1): 115-124. ( PubMed )

  1. T Ohteki, S Ho, H Suzuki, T W Mak, P S Ohashi: Role for IL-15/IL-15 receptor beta-chain in natural killer 1.1+ T cell receptor-alpha beta+ cell development. J Immunol. 1997.12; 159 (12): 5931-5935. ( PubMed )

  2. M F Bachmann, T Ohteki, K M Faienza, A Zakarian, D Kägi, D E Speiser, P S Ohashi: Altered peptide ligands trigger perforin- rather than Fas-dependent cell lysis. J Immunol. 1997.11; 159 (9): 4165-4170. ( PubMed )

  3. M Shimamura, T Ohteki, U Beutner, H R MacDonald: Lack of directed V alpha 14-J alpha 281 rearrangements in NK1+ T cells. Eur J Immunol. 1997.06; 27 (6): 1576-1579. ( PubMed , DOI )

  4. M Shimamura, T Ohteki, P Launois, A M Garcia, H R MacDonald: Thymus-independent generation of NK1+ T cells in vitro from fetal liver precursors. J Immunol. 1997.04; 158 (8): 3682-3689. ( PubMed )

  5. U Beutner, P Launois, T Ohteki, J A Louis, H R MacDonald: Natural killer-like T cells develop in SJL mice despite genetically distinct defects in NK1.1 expression and in inducible interleukin-4 production. Eur J Immunol. 1997.04; 27 (4): 928-934. ( PubMed , DOI )

  1. DE Speiser, E Sebzda, T Ohteki, M F Bachmann, K Pfeffer, TW Mak, PS Ohashi: Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo. Eur. J. Immunol.. 1996.12; 26 (12): 3055-3060. ( PubMed , DOI )

  2. T Ohteki, H R MacDonald: Stringent V beta requirement for the development of NK1.1+ T cell receptor-alpha/beta+ cells in mouse liver. J. Exp. Med.. 1996.03; 183 (3): 1277-1282. ( PubMed )

  3. T Ohteki, A Wilson, S Verbeek, H R MacDonald, H Clevers: Selectively impaired development of intestinal T cell receptor gamma delta+ cells and liver CD4+ NK1+ T cell receptor alpha beta+ cells in T cell factor-1-deficient mice. Eur. J. Immunol.. 1996.02; 26 (2): 351-355. ( PubMed , DOI )

  1. P Launois, T Ohteki, K Swihart, H R MacDonald, J A Louis: In susceptible mice, Leishmania major induce very rapid interleukin-4 production by CD4+ T cells which are NK1.1-. Eur. J. Immunol.. 1995.12; 25 (12): 3298-3307. ( PubMed , DOI )

  2. P R Walker, T Ohteki, J A Lopez, H R MacDonald, J L Maryanski: Distinct phenotypes of antigen-selected CD8 T cells emerge at different stages of an in vivo immune response. J. Immunol.. 1995.10; 155 (7): 3443-3452. ( PubMed )

  3. T Ohteki, M Iwamoto, S Izui, H R MacDonald: Reduced development of CD4-8-B220+ T cells but normal autoantibody production in lpr/lpr mice lacking major histocompatibility complex class I molecules. Eur. J. Immunol.. 1995.01; 25 (1): 37-41. ( PubMed , DOI )

  1. T Ohteki, H R MacDonald: Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice. J. Exp. Med.. 1994.08; 180 (2): 699-704. ( PubMed )

  2. J P Rosat, M Schreyer, T Ohteki, G A Waanders, H R MacDonald, J A Louis: Selective expansion of activated V delta 4+ cells during experimental infection of mice with Leishmania major. Eur. J. Immunol.. 1994.02; 24 (2): 496-499. ( PubMed , DOI )

  1. N Koyamada, T Ohteki, T Abo, T Fukumori, N Ohkouchi, S Satomi, Y Taguchi, A Kusumi, S Mori, K Kumagai: Induction of specific tolerance by hepatic double-negative CD4-8- alpha beta T cells of mice immunized with allogeneic cells via the portal vein in vivo [corrected]. Cell. Immunol.. 1993.06; 149 (1): 107-116. ( PubMed )

  2. T Ohteki, H R MacDonald: Expression of the CD28 costimulatory molecule on subsets of murine intestinal intraepithelial lymphocytes correlates with lineage and responsiveness. Eur. J. Immunol.. 1993.06; 23 (6): 1251-1255. ( PubMed , DOI )

  3. T Ohteki, S Okamoto, M Nakamura, E Nemoto, K Kumagai: Elevated production of interleukin 6 by hepatic MNC correlates with ICAM-1 expression on the hepatic sinusoidal endothelial cells in autoimmune MRL/lpr mice. Immunol. Lett.. 1993.05; 36 (2): 145-152. ( PubMed )

  4. T Ohteki, T Abo, A Kusumi, T Sasaki, S Shibata, S Seki, K Kumagai: Age-associated increase of CD5+ B cells in the liver of autoimmune (NZB x NZW) F1 mice. Microbiol. Immunol.. 1993.01; 37 (3): 221-228. ( PubMed )

  1. T Iiai, H Watanabe, S Seki, K Sugiura, K Hirokawa, M Utsuyama, H Takahashi-Iwanaga, T Iwanaga, T Ohteki, T Abo: Ontogeny and development of extrathymic T cells in mouse liver. Immunology. 1992.12; 77 (4): 556-563. ( PubMed )

  2. A Kusumi, T Abo, T Masuda, K Sugiura, S Seki, T Ohteki, R Okuyama, K Kumagai: Lymphotoxin activates hepatic T cells and simultaneously induces profound thymic atrophy. Immunology. 1992.10; 77 (2): 177-184. ( PubMed )

  3. T Ohteki, R Okuyama, S Seki, T Abo, K Sugiura, A Kusumi, T Ohmori, H Watanabe, K Kumagai: Age-dependent increase of extrathymic T cells in the liver and their appearance in the periphery of older mice. J. Immunol.. 1992.09; 149 (5): 1562-1570. ( PubMed )

  4. T Abo, A Kusumi, S Seki, T Ohteki, K Sugiura, T Masuda, H Rikiishi, T Iiai, K Kumagai: Activation of extrathymic T cells in the liver and reciprocal inactivation of intrathymic T cells by bacterial stimulation. Cell. Immunol.. 1992.06; 142 (1): 125-136. ( PubMed )

  5. R Okuyama, T Abo, S Seki, T Ohteki, K Sugiura, A Kusumi, K Kumagai: Estrogen administration activates extrathymic T cell differentiation in the liver. J. Exp. Med.. 1992.03; 175 (3): 661-669. ( PubMed )

  6. H Watanabe, K Ohtsuka, M Kimura, Y Ikarashi, K Ohmori, A Kusumi, T Ohteki, S Seki, T Abo: Details of an isolation method for hepatic lymphocytes in mice. J. Immunol. Methods. 1992.02; 146 (2): 145-154. ( PubMed )

  1. T Masuda, T Ohteki, T Abo, S Seki, S Nose, H Nagura, K Kumagai: Expansion of the population of double negative CD4-8- T alpha beta-cells in the liver is a common feature of autoimmune mice. J. Immunol.. 1991.11; 147 (9): 2907-2912. ( PubMed )

  2. S Seki, T Abo, K Sugiura, T Ohteki, T Kobata, H Yagita, K Okumura, H Rikiishi, T Masuda, K Kumagai: Reciprocal T cell responses in the liver and thymus of mice injected with syngeneic tumor cells. Cell. Immunol.. 1991.10; 137 (1): 46-60. ( PubMed )

  3. T Abo, T Ohteki, S Seki, N Koyamada, Y Yoshikai, T Masuda, H Rikiishi, K Kumagai: The appearance of T cells bearing self-reactive T cell receptor in the livers of mice injected with bacteria. J. Exp. Med.. 1991.08; 174 (2): 417-424. ( PubMed )

  4. S Seki, T Abo, T Ohteki, K Sugiura, K Kumagai: Unusual alpha beta-T cells expanded in autoimmune lpr mice are probably a counterpart of normal T cells in the liver. J. Immunol.. 1991.08; 147 (4): 1214-1221. ( PubMed )

  5. T Ohteki, T Abo, S Seki, T Kobata, H Yagita, K Okumura, K Kumagai: Predominant appearance of gamma/delta T lymphocytes in the liver of mice after birth. Eur. J. Immunol.. 1991.07; 21 (7): 1733-1740. ( PubMed , DOI )

  1. J Satoh, H Seino, S Shintani, S Tanaka, T Ohteki, T Masuda, T Nobunaga, T Toyota: Inhibition of type 1 diabetes in BB rats with recombinant human tumor necrosis factor-alpha. J. Immunol.. 1990.09; 145 (5): 1395-1399. ( PubMed )

  2. S Seki, T Abo, T Masuda, T Ohteki, A Kanno, K Takeda, H Rikiishi, H Nagura, K Kumagai: Identification of activated T cell receptor gamma delta lymphocytes in the liver of tumor-bearing hosts. J. Clin. Invest.. 1990.08; 86 (2): 409-415. ( PubMed , DOI )

  3. T Ohteki, S Seki, T Abo, K Kumagai: Liver is a possible site for the proliferation of abnormal CD3+4-8- double-negative lymphocytes in autoimmune MRL-lpr/lpr mice. J. Exp. Med.. 1990.07; 172 (1): 7-12. ( PubMed )

  4. Toshiaki Ohteki: Analysis of lymphoproliferative disorders in autoimmune model mouse (MRL-lpr/lpr) accompanying Sjögren’s syndrome. Tohoku Univ Dent J. 1990.01; 9 73-82.

  1. J Satoh, H Seino, T Abo, S Tanaka, S Shintani, S Ohta, K Tamura, T Sawai, T Nobunaga, T Oteki: Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice. J. Clin. Invest.. 1989.10; 84 (4): 1345-1348. ( PubMed , DOI )

  1. Masashi Kanayama, Mari L. Shinohara: Balancing population sizes of myeloid and lymphoid cells by osteopontin isoforms 2018.03; 63 (3): 219-224.

  2. Toshiaki Ohteki: Identification of a human progenitor strictly committed to monocytic differentiation: a counterpart of mouse cMoPs. Rinsho Ketsueki. 2018; 59 (6): 812-818. ( PubMed , DOI )

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