Department of Biomolecular Pathogenesis

40  articles.  
* There may be some overlapped articles listed due to the difference of format.

  1. Yamano K, Kinefuchi H, Kojima W: Mitochondrial lipid dynamics regulated by MITOL-mediated ubiquitination. Journal of biochemistry. 2024.03; 175 (3): 217-219. ( PubMed , DOI )

  2. Cui M, Yamano K, Yamamoto K, Yamamoto-Imoto H, Minami S, Yamamoto T, Matsui S, Kaminishi T, Shima T, Ogura M, Tsuchiya M, Nishino K, Layden BT, Kato H, Ogawa H, Oki S, Okada Y, Isaka Y, Kosako H, Matsuda N, Yoshimori T, Nakamura S: HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence. Proceedings of the National Academy of Sciences of the United States of America. 2024.01; 121 (2): e2306454120. ( PubMed , DOI )

  3. Yamano K, Sawada M, Kikuchi R, Nagataki K, Kojima W, Endo R, Kinefuchi H, Sugihara A, Fujino T, Watanabe A, Tanaka K, Hayashi G, Murakami H, Matsuda N: Optineurin provides a mitophagy contact site for TBK1 activation. The EMBO journal. 2024.01; 43 (5): 754-779. ( PubMed , DOI )

  4. Kawasaki I, Sugiura K, Sasaki T, Matsuda N, Sato M, Sato K: MARC-3, a membrane-associated ubiquitin ligase, is required for fast polyspermy block in Caenorhabditis elegans. Nature communications. 2024.01; 15 (1): 792. ( PubMed , DOI )

  1. Yamano K, Kinefuchi H, Kojima W: Mitochondrial quality control via organelle and protein degradation. Journal of biochemistry. 2023.12; ( PubMed , DOI )

  2. Kurusu R, Fujimoto Y, Morishita H, Noshiro D, Takada S, Yamano K, Tanaka H, Arai R, Kageyama S, Funakoshi T, Komatsu-Hirota S, Taka H, Kazuno S, Miura Y, Koike M, Wakai T, Waguri S, Noda NN, Komatsu M: Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex. Developmental cell. 2023.07; 58 (13): 1189-1205.e11. ( PubMed , DOI )

  3. Akabane S, Watanabe K, Kosako H, Yamashita SI, Nishino K, Kato M, Sekine S, Kanki T, Matsuda N, Endo T, Oka T: TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria. Cell reports. 2023.05; 42 (5): 112454. ( PubMed , DOI )

  4. Yamano K, Sawada M, Kikuchi R, Nagataki K, Kojima W, Sugihara A, Fujino T, Tanaka K, Hayashi G, Murakami H, Matsuda N. : Optineurin provides a mitophagy contact site for TBK1 activation bioRxiv. 2023.02;

  5. Hayashida R, Kikuchi R, Imai K, Kojima W, Yamada T, Iijima M, Sesaki H, Tanaka K, Matsuda N, Yamano K: Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid-liquid phase separation-based method. The Journal of biological chemistry. 2023.02; 299 (2): 102822. ( PubMed , DOI )

  1. Bruno Barros Queliconi, Waka Kojima, Mayumi Kimura, Kenichiro Imai, Chisato Udagawa, Chie Motono, Takatsugu Hirokawa, Shinya Tashiro, Jose M M Caaveiro, Kouhei Tsumoto, Koji Yamano, Keiji Tanaka, Noriyuki Matsuda: Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-1. J Cell Sci. 2021.11; 134 (22): jcs258653. ( PubMed , DOI )

  2. Yamano K, Kojima W: Molecular functions of autophagy adaptors upon ubiquitin-driven mitophagy. Biochimica et biophysica acta. General subjects. 2021.10; 1865 (10): 129972. ( PubMed , DOI )

  3. Waka Kojima, Koji Yamano, Hidetaka Kosako, Kenichiro Imai, Reika Kikuchi, Keiji Tanaka, Noriyuki Matsuda: Mammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy. Autophagy. 2021.08; 17 (8): 2011-2036. ( PubMed , DOI )

  4. Yukiko Yoshida, Makoto Asahina, Arisa Murakami, Junko Kawawaki, Meari Yoshida, Reiko Fujinawa, Kazuhiro Iwai, Ryuichi Tozawa, Noriyuki Matsuda, Keiji Tanaka, Tadashi Suzuki: Loss of peptide N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase. Proc Natl Acad Sci U S A. 2021.07; 118 (27): e2102902118. ( PubMed , DOI )

  5. Taiki Baba, Susumu Tanimura, Ayane Yamaguchi, Koichiro Horikawa, Masashi Yokozeki, Saki Hachiya, Shun-Ichiro Iemura, Tohru Natsume, Noriyuki Matsuda, Kohsuke Takeda: Cleaved PGAM5 dephosphorylates nuclear serine/arginine-rich proteins during mitophagy. Biochim Biophys Acta Mol Cell Res. 2021.07; 1868 (7): 119045. ( PubMed , DOI )

  6. Mashun Onishi, Koji Yamano, Miyuki Sato, Noriyuki Matsuda, Koji Okamoto: Molecular mechanisms and physiological functions of mitophagy. EMBO J. 2021.02; 40 (3): e104705. ( PubMed , DOI )

  1. Yamano K, Youle RJ: Two different axes CALCOCO2-RB1CC1 and OPTN-ATG9A initiate PRKN-mediated mitophagy. Autophagy. 2020.11; 16 (11): 2105-2107. ( PubMed , DOI )

  2. Matsuda Noriyuki, Yamano Koji: コインの裏表　損傷誘発性のPINK1とParkinのミトコンドリア局在性に関する生理的意義と分子機序(Two sides of a coin: Physiological significance and molecular mechanisms for damage-induced mitochondrial localization of PINK1 and Parkin) Neuroscience Research. 2020.10; 159 16-24. ( ichushi )

  3. Matsuda N, Yamano K: Two sides of a coin: Physiological significance and molecular mechanisms for damage-induced mitochondrial localization of PINK1 and Parkin. Neuroscience research. 2020.10; 159 16-24. ( PubMed , DOI )

  4. Yamano K, Kikuchi R, Kojima W, Hayashida R, Koyano F, Kawawaki J, Shoda T, Demizu Y, Naito M, Tanaka K, Matsuda N: Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy. The Journal of cell biology. 2020.09; 219 (9): ( PubMed , DOI )

  1. Koyano F, Yamano K, Kosako H, Kimura Y, Kimura M, Fujiki Y, Tanaka K, Matsuda N: Parkin-mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes. EMBO reports. 2019.12; 20 (12): e47728. ( PubMed , DOI )

  2. Koyano F, Yamano K, Kosako H, Tanaka K, Matsuda N: Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL. The Journal of biological chemistry. 2019.06; 294 (26): 10300-10314. ( PubMed , DOI )

  3. Yamaguchi Ayane, Ishikawa Hayate, Furuoka Mana, Yokozeki Masashi, Matsuda Noriyuki, Tanimura Susumu, Takeda Kohsuke: 切断型PGAM5はマイトファジー中のミトコンドリア外膜のプロテオソーム介在性断裂に応じてミトコンドリアから放出される(Cleaved PGAM5 is released from mitochondria depending on proteasome-mediated rupture of the outer mitochondrial membrane during mitophagy) The Journal of Biochemistry. 2019.01; 165 (1): 19-25. ( ichushi )

  4. Yamaguchi A, Ishikawa H, Furuoka M, Yokozeki M, Matsuda N, Tanimura S, Takeda K: Cleaved PGAM5 is released from mitochondria depending on proteasome-mediated rupture of the outer mitochondrial membrane during mitophagy. Journal of biochemistry. 2019.01; 165 (1): 19-25. ( PubMed , DOI )

  1. Yamano K, Lazarou M: YoungMito 2018: Report on the 1st International Mitochondria Meeting for Young Scientists. Genes to cells : devoted to molecular & cellular mechanisms. 2018.10; 23 (10): 822-827. ( PubMed , DOI )

  2. Tashiro S, Caaveiro JMM, Nakakido M, Tanabe A, Nagatoishi S, Tamura Y, Matsuda N, Liu D, Hoang QQ, Tsumoto K: Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1. ACS chemical biology. 2018.09; 13 (9): 2783-2793. ( PubMed , DOI )

  3. Okatsu K, Sato Y, Yamano K, Matsuda N, Negishi L, Takahashi A, Yamagata A, Goto-Ito S, Mishima M, Ito Y, Oka T, Tanaka K, Fukai S: Structural insights into ubiquitin phosphorylation by PINK1. Scientific reports. 2018.07; 8 (1): 10382. ( PubMed , DOI )

  4. Yamano K, Wang C, Sarraf SA, Münch C, Kikuchi R, Noda NN, Hizukuri Y, Kanemaki MT, Harper W, Tanaka K, Matsuda N, Youle RJ: Endosomal Rab cycles regulate Parkin-mediated mitophagy. eLife. 2018.01; 7 ( PubMed , DOI )

  1. Sato Y, Okatsu K, Saeki Y, Yamano K, Matsuda N, Kaiho A, Yamagata A, Goto-Ito S, Ishikawa M, Hashimoto Y, Tanaka K, Fukai S: Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30. Nature structural & molecular biology. 2017.11; 24 (11): 911-919. ( PubMed , DOI )

  2. Matsuda N, Kimura M, Queliconi BB, Kojima W, Mishima M, Takagi K, Koyano F, Yamano K, Mizushima T, Ito Y, Tanaka K: Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro. Scientific reports. 2017.10; 7 (1): 12816. ( PubMed , DOI )

  3. Izumikawa K, Nobe Y, Yoshikawa H, Ishikawa H, Miura Y, Nakayama H, Nonaka T, Hasegawa M, Egawa N, Inoue H, Nishikawa K, Yamano K, Simpson RJ, Taoka M, Yamauchi Y, Isobe T, Takahashi N: TDP-43 stabilises the processing intermediates of mitochondrial transcripts. Scientific reports. 2017.08; 7 (1): 7709. ( PubMed , DOI )

  4. Yoshida Y, Yasuda S, Fujita T, Hamasaki M, Murakami A, Kawawaki J, Iwai K, Saeki Y, Yoshimori T, Matsuda N, Tanaka K: Ubiquitination of exposed glycoproteins by SCF(FBXO27) directs damaged lysosomes for autophagy. Proceedings of the National Academy of Sciences of the United States of America. 2017.08; 114 (32): 8574-8579. ( PubMed , DOI )

  5. Unexpected mitochondrial matrix localization of Parkinson's disease-related DJ-1 mutants but not wild-type DJ-1 (vol 21, pg 772, 2016) 2017.01; 22 (1): 124. ( DOI )

  1. Noriyuki Matsuda: Current methods and problems to monitor mitophagy correctly - considered from Parkin study. Experimental Medicine. 2023.03; 41 (5): 682-687. ( ichushi )

  1. 平石 萌, 小谷野 史香, 久永 眞市, 中田 和人, 田中 啓二, 松田 憲之: Parkin機能喪失に由来するパーキンソン病モデルマウスの作製と解析 生命科学系学会合同年次大会. 2017.12; 2017年度 [2P-1068]. ( ichushi )

  2. 佐藤 裕介, 尾勝 圭, 佐伯 泰, 山野 晃史, 松田 憲之, 海保 愛, 山形 敦史, 伊藤 桜子, 石川 稔, 橋本 祐一, 田中 啓二, 深井 周也: ユビキチン・コード:細胞内の最も難解な暗号を読む USP30によるLys6結合型ユビキチン鎖特異的切断機構の構造的基盤 生命科学系学会合同年次大会. 2017.12; 2017年度 [4AW13-6]. ( ichushi )

  3. 小島 和華, 山野 晃史, 木村 まゆみ, Bruno Queliconi, 田中 啓二, 松田 憲之: DJ-1の局在解析から見出す非典型的ミトコンドリア局在化シグナル 生命科学系学会合同年次大会. 2017.12; 2017年度 [1P-0324]. ( ichushi )

  4. PINK1-PhosphoUbiquitin-Parkin axis for degradation of damaged mitochondria 2017.08; 262 (6): 603-608.

  5. 吉田雪子, 安田さや香, 藤田敏治, 濱崎万穂, 村上有沙, 川脇純子, 岩井一宏, 佐伯泰, 吉森保, 松田憲之, 田中啓二: SCFFBXO27による損傷リソソームから細胞質へ露出した糖蛋白質のユビキチン化はリソファジーの引き金となる 日本生化学会大会(Web). 2017; 90th ROMBUNNO.4LT01‐08(3P‐0149) (WEB ONLY)-0149)]. ( ichushi )

  1. Koji Yamano, Reika Kikuchi, Waka Kojima, Ryota Hayashida, Fumika Koyano, Junko Kawawaki, Takuji Shoda, Yosuke Demizu, Mikihiko Naito, Keiji Tanaka, Noriyuki Matsuda: Critical role of mitochondrial ubiquitination and the OPTN ATG9A axis in mitophagy Journal of Cell Biology. 2020.09; 219 (9): ( PubMed , DOI )

  1. 尾勝圭, 松田憲之, 深井周也: PINK1 activation by its unconventional localization to the outer mitochondrial membrane 日本分子生物学会年会プログラム・要旨集(Web). 2019; 42nd

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