Takeshi Tsubata. Regulation of B cells and autoimmune diseases. The 48th Annual Meeting of the Japanese Society for Immunology (JSI) 2019.12.13 Hamamatsu, SHIZUOKA

安達貴弘、渡部太郎、永石宇司、渡邉 守、烏山 一、吉川宗一郎. IgA deficiency causes spontaneous enteritis. 第48回日本免疫学会学術集会、浜松 2019.12.13

安達貴弘、渡部太郎、永石宇司、渡邉 守、烏山 一、吉川宗一郎. IgA deficiency causes spontaneous enteritis. 第48回日本免疫学会学術集会、浜松 2019.12.13

Adachi, T., Watabe, T., Nagaishi, T, Watanabe, M., Karasuyama, H., Yoshikawa,S.. IgA deficiency causes spontaneous enteritis . The 48th Annual Meeting of the Japanese Society for Immunology (JSI) 2019.12.13 Hamamatsu, SHIZUOKA

Chizuru Akatsu, Quan-Zhen Li, Hideharu Sekine, Teizo Fujita, Takeshi Tsubata. The inhibitory B cell co-receptor CD72 recognizes various lupus self-antigens including C1q and inhibits B cell responses to these self-antigen . The 48th Annual Meeting of the Japanese Society for Immunology (JSI) 2019.12.12 Hamamatsu, SHIZUOKA

Ying Wang, Jun Liu, Ermeng Xiong, Chizuru Akatsu, Takeshi Tsubata, Ji-Yang Wang. LAPTM5 mediates anti-IgM-induced apoptosis in immature B cells. The 48th Annual Meeting of the Japanese Society for Immunology (JSI) 2019.12.12 Hamamatsu, SHIZUOKA

Yang-Yang Feng, Jun Liu, Ji-Yang Wang, Takeshi Tsubata . Essential role of late redoxosome in BCR ligation-induced B cell activation. The 48th Annual Meeting of the Japanese Society for Immunology (JSI) 2019.12.12 Hamamatsu, SHIZUOKA

Kyoko Nishida, Akihiro Kimura, Takeshi Tsubata, Harumi Suzuki. The anti-oxidative enzyme NAD(P)H quinone oxidoreductase1 promotes Th17 cells differentiation by protecting oxidative stress. The 48th Annual Meeting of the Japanese Society for Immunology (JSI) 2019.12.12 Hamamatsu, SHIZUOKA

Liu, J., Qian, J., Xiong, E., Zhang, L., Wang, Y., Chu, Y., Tsubata, T. and Wang, J.-Y.. Role of the IgM Fc receptor in marginal zone B cell development and function. The 48th Annual Meeting of the Japanese Society for Immunology (JSI) 2019.12.12 Hamamatsu, SHIZUOKA

Xiong, E., Cui, C., Min, Q., Liu, J., Lai, N., Wang, Y., Matsumoto, R., Takahashi, D., Hase, K., Shinkura, R., Tsubata, T. and Wang, J.-Y.. MZB1 promotes the secretion of J chain-containing IgA and is critical for the suppression of gut inflammation. The 48th Annual Meeting of the Japanese Society for Immunology (JSI) 2019.12.12 Hamamatsu, SHIZUOKA

Tang, Y., Lai, N., Xiong, E., Ouchida, R., Sun, J., Hikida, M., Tsubata, T., Wang, Y. and Wang, J.-Y.. Distinct roles of B cell novel protein 1 in B cell development and activation. The 48th Annual Meeting of the Japanese Society for Immunology (JSI) 2019.12.12 Hamamatsu, SHIZUOKA

Naoya Tsugawa, Takashi Nagaishi, Daiki Yamada, Toshimitsu Fujii, Yudai Kojima, Arisa Tokai, Taro Watabe, Shuang Wang, Michio Onizawa, Takahiro Adachi, Mamoru Watanabe. BCR signaling in the activated B cells may be regulated by the long isoform of Ceacam1. The 48th Annual Meeting of the Japanese Society for Immunology 2019.12.11 Hamamatsu（Japan）

福田陽大 ,越阪部奈緒美,安達貴弘. Elucidation of recognition mechanism of dorsal root ganglion for food factors. 第9回The international conference on food factors(ICoFF2019) 2019.12.03

福田陽大 ,越阪部奈緒美,安達貴弘. Elucidation of recognition mechanism of dorsal root ganglion for food factors. 第9回The international conference on food factors(ICoFF2019) 2019.12.03

Fukuda, Y., Osakabe, N., Adachi,, T.. Elucidation of recognition mechanism of dorsal root ganglion for food factors. The international conference on food factors(ICoFF2019) 2019.12.03 Kobe

Takeshi Tsubata. Regulation of the immune response to nucleic acids and systemic lupuserythematosus. The 1st “Wuxi talents” Symposium of Experimental Research Center of the First People’s Hospital of Huaihua 2019.11.29 Huaihua, CHINA

Takeshi Tsubata. SHP-1 (PTPN6) regulates development of SLE through CD72. The 4th Taiwan-Japan Bilateral Conference on Protein Phosphatase 2019.11.15 Taipei,TAIWAN

Takeshi Tsubata. Inhibitory B cell co-receptors and autoimmune diseases. Mini-symposium on Protein Structure and Function 2019.10.03 Taipei,TAIWAN

YangYang Feng, Miao Tang, Mitsuhiro Suzuki, Chinthika Gunasekara, Yuki Anbe, Yuichi Hiraoka, Jun Liu, JiYang Wang, Takeshi Tsubata. Essential role of NOX3-mediated endosomal production of ROS in maintenance of sustained B cell receptor signaling and B cell proliferation. The 92nd Annual Meeting of the Japanese Biochemical Society 2019.09.18 Yokohama, KANAGAWA

Daiki Yamada, Takashi Nagaishi, Taro Watabe, Naoya Tsugawa, Yudai Kojima, Takahiro Adachi, Mamoru Watanabe. Analysis of Ileocecal Immune Response in an Animal Model of Colitis. ICMI2019 2019.07.17 Brisbane（Australia）

Yang-Yang Feng, Miao Tang, Mitsuhiro Suzuki, Chinthika Gunasekara, Yuki Anbe, Yuichi Hiraoka, Jun Liu, Helmut Grasberger, Mamoru Ohkita, Yasuo Matsumura, Ji-Yang Wang, and Takeshi Tsubata. Essential role of NADPH oxidase-dependent production of reactive oxygen species in maintenance of sustained B cell receptor signaling and B cell proliferation. The 28th Annual Meeting of the Japanese Society for Cell Death Research 2019.07.13 TOKYO

Long　Wang、Endo　Ayaka、Takematsu　Hiromu、Fedder　Thomas、Tsubata　Takeshi. Development of anti-CD22 antibody that inhibits ligand binding of CD22. The Regular Meeting of the Japanese Biochemical Society Kanto Branch 2019.06.22 Yokohama, KANAGAWA

Yota FUKUDA, Naomi OSAKABE, Takahiro ADACHI. Establishment of intravital imaging method to evaluate the sensing mechanism in the gastrointestinal tract of food factors. 2019.03.26

Masanori ITAKURA, Eita SASAKI, Takahiro ADACHI, Koji UCHIDA. Dehydroascorbic acid-modified serum albumin activate innate immunity. 2019.03.26

Yota FUKUDA, Naomi OSAKABE, Takahiro ADACHI. Establishment of intravital imaging method to evaluate the sensing mechanism in the gastrointestinal tract of food factors. 2019.03.26

Ryunosuke ENDO, Masanori ITAKURA, Eita SASAKI, Takahiro ADACHI, Koji UCHIDA. The analysis of IgM producing mechanism induced by acrolein-modified protein. 2019.03.26

Ryunosuke ENDO, Masanori ITAKURA, Eita SASAKI, Takahiro ADACHI, Koji UCHIDA. The analysis of IgM producing mechanism induced by acrolein-modified protein. 2019.03.26

Masanori ITAKURA, Eita SASAKI, Takahiro ADACHI, Koji UCHIDA. Dehydroascorbic acid-modified serum albumin activate innate immunity. 2019.03.26

Toshihiko KUMAZAWA, Atsuhisa NISHIMURA, Noriyuki ASAI, Takahiro ADACHI. Isolation of immune-regulatory Tetragenococcus halophilus from miso. 2019.03.24

Toshihiko KUMAZAWA, Atsuhisa NISHIMURA, Noriyuki ASAI, Takahiro ADACHI. Isolation of immune-regulatory Tetragenococcus halophilus from miso. 2019.03.24

Yangyang Feng, Jun Liu, Helmut Grasberger, Ji-Yang Wang, Takeshi Tsubata. Essential role of NADPH oxidase-dependent production of reactive oxygen species in maintenance of sustained B cell receptor signaling and B cell proliferation . The 47th Annual Meeting of the Japanese Society for Immunology 2018.12.10 Fukuoka

Xuexin Li, Soha Gomaa Ramadan Abdel Salam, Matthew Routledge, Yuki Hitomi, Susumu Kusunoki, Takeshi Tsubata. Significant associations of human SIGLEC10 polymorphisms with susceptibility to Guillain-Barré syndrome. The 47th Annual Meeting of the Japanese Society for Immunology 2018.12.10 Fukuoka

Kyoko Nishida, Akihiro Kimura, Takeshi Tsubata, Harumi Suzuki. NQO1 regulates pathogenisity of Th17 cells by suppressing IL-10 production. The 47th Annual Meeting of the Japanese Society for Immunology 2018.12.10 Fukuoka

Chizuru Akatsu, Quan-Zhen Li, and Takeshi Tsubata. Roles of CD72 in the regulation of autoantibody production and type 1 interferon production in autoimmune disease. The 47th Annual Meeting of the Japanese Society for Immunology 2018.12.10 Fukuoka

Chizuru Akatsu, Xuexin Li, Susumu Kusunoki, Takeshi Tsuabta. SHP-1-activating B lymphocyte co-receptors and autoimmune diseases. The 47th Annual Meeting of the Japanese Society for Immunology 2018.12.10 Fukuoka

Takeshi Tsuabta. Ligand recognition determines functional properties of inhibitory B cell co-receptors. International Symposium on B cells 2018.12.07 Shanghai,China

Yoshikawa Soichiro, Tabakawa Yuya, Ohta Takuya, Yamaji Kayoko, Ishiwata Kenji, Kawano Yohei, Yamanishi Yoshinori, Ohtsu Hiroshi, Adachi Takahiro, Watanabe Naohiro, Kanuka Hirotaka, Karasuyama Hajime. 肥満細胞と顆粒球　肥満細胞ではなく皮膚浸潤好塩基球から放出されるhistamineはマウスにおいてマダニ抵抗性の獲得に極めて重要である(Mast cells & granulocytes　Histamine released from skin-infiltrating basophils but not mast cells is crucial for acquired tick resistance in mice). 日本免疫学会総会・学術集会記録 2018.12.01

Adachi Takahiro, Karasuyama Hajime, Yoshikawa Soichiro. B細胞　疾患におけるB細胞の役割と調節　免疫細胞におけるCa2+シグナル伝達の動態は免疫疾患の素因と前病的状態を予測する(B cells-2:Roles and regulation of B cells in diseases　Kinetics of Ca2+ signaling in immune cells predict predisposition and pre-pathological conditions of the immune diseases). 日本免疫学会総会・学術集会記録 2018.12.01

Chinthika Gunasekara、Kozo Watanabe、Takeshi Tsubata. Reactive oxygen species play a role in endosomal B cell antigen receptor signaling. 7th Federation of Immunological Societies of Asia-Oceania (FIMSA) Congress 2018 2018.11.10 Bangkok,Thailand

Yang-Yang Feng, Miao Tang, Mitsuhiro Suzuki, Jun Liu, Helmut Grasberger, Ji-Yang Wang and Takeshi Tsubata. Essential role of NADPH oxidases in BCR signaling and B cell proliferation. Workshop on Frontiers in Phosphatase Research and Drug Discovery (ICPP13) 2018.10.23 Tokyo

Amin Alborzian Deh Sheikh, Chizuru Akatsu, Hideharu Ishida and Takeshi Tsubata. The role of ligand recognition of SHP-1 activating receptor CD22 in the regulation of B cell tonic signaling. Workshop on Frontiers in Phosphatase Research and Drug Discovery (ICPP13) 2018.10.23 Tokyo

Moe Endo, Chizuru Akatsu, Quan-Zhen Li, Chengsong Zhu, Teizo Fujita, Hideharu Sekine, Takeshi Tsubata. Ligand recognition of the SHP-1-activating inhibitory B cell co-receptor CD72. Workshop on Frontiers in Phosphatase Research and Drug Discovery (ICPP13) 2018.10.23 Tokyo

Chizuru Akatsu, Xuexin Li, Susumu Kusunoki, Takeshi Tsuabta. SHP-1-activating B lymphocyte co-receptors and autoimmune diseases. Workshop on Frontiers in Phosphatase Research and Drug Discovery (ICPP13) 2018.10.23 Tokyo

Takeshi Tsubata. Essential role of NADPH oxidase-dependent production of reactive oxygen species in maintenance of sustained B cell receptor signaling and B cell proliferation. 2018.06.25 Freiburg, Germany

Yang-Yang Feng, Miao Tang, Mitsuhiro Suzuki, Jun Liu, Helmut Grasberger, Mamoru Ohkita, Yasuo Matsumura, Ji-Yang Wang, and Takeshi Tsubata. Role of NADPH oxidases in BCR signaling and B cell proliferation. The Regular Meeting of the Japanese Biochemical Society Kanto Branchranch 2018.06.23 Saitama

Amin Alborzian Deh Sheikh, Chizuru Akatsu, Hideharu Ishida and Takeshi Tsubata. The role of CD22 glycan cis-ligands in the regulation of B cell tonic signaling. The Regular Meeting of the Japanese Biochemical Society Kanto Branch 2018.06.23 Saitama

Takeshi Tsubata. The Inhibitory B Cell Co-Receptor CD72 Regulates Tolerance to Self Nucleic Acids Crucial for Development of Systemic Lupus Erythematosus. Keystone Symposia, B cells: Mechanisms in Immunity and Autoimmunity 2018.06.21 Dresden, Germany

Takeshi Tsubata. Endogenous ligands of inhibitory B cell co-receptors. 2018.06.15 Berlin, Germany

Takeshi Tsubata. Endogenous ligands of inhibitory B lymphocyte co-receptors. 2018.06.14 Zürich, Switzerland

Takeshi Tsubata. Inhibitory B cell co-receptors and autoimmune diseases. 45th IMSUT Founding Commemorative Symposium "A new era of medical researches created by disease models" 2018.06.01 Tokyo

Takashi Nagaishi, Naoya Tsugawa, Taro Watabe, Akinori Hosoya, Nisha Jose, Yudai Kojima, Takahiro Adachi, Mamoru Watanabe. Verification of intestinal microflora-mediated mucosal homeostasis by immunoglobulin A. The 11th International Gastrointestinal Consensus Symposium 2018.02.10 Tokyo

Nagaishi Takashi, Watabe Taro, Hosoya Akinori, Nisha Jose, Kojima Yudai, Adachi Takahiro, Watanabe Mamoru. 免疫グロブリンAによる腸細菌叢介在性粘膜ホメオスタシスの検証(Verification of intestinal microflora-mediated mucosal homeostasis by immunoglobulin A). 日本消化管学会雑誌 2018.02.01

安達 貴弘. Intravital imaging of cellular signaling in immune cells．. Stem Cell Traits and Developmental Systems．KEY Forum 2018 2018.01.11

Takahiro Adachi. Intravital imaging of cellular signaling in immune cells．The 3rd International Symposium on Stem Cell Traits and Developmental Systems. KEY Forum 2018 2018.01.11 Kumamoto

安達 貴弘. Intravital imaging of cellular signaling in immune cells．. Stem Cell Traits and Developmental Systems．KEY Forum 2018 2018.01.11

安達 貴弘, 吉川 宗一郎, 烏山 一. Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice.. The 46th Annual Meeting of The Japanese Society for Immunology,Sendai 2017.12.14

Takahiro Adachi, Soichiro Yoshikawa, Hajime Karasuyama. Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai

MEDZHIDOV Nazim, TAKATA Toshitaro, SUZUKI Mitsuhiro, ICHINOSE Shizuko, YAMAGUCHI Hirofumi, ARAKAWA Satoko, SHIMIZU Shigeomi, TSUBATA Takeshi.. Role of poor B cell receptor ubiquitination in efficient antigen presentation. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai

Feng Yangyang, Rengarajan Sundararaman, Tang Miao, Tsubata Takeshi. Role of NADPH oxidases in BCR ligation-induced ROS production and activation. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai

Taro Watabe, Takashi Nagaishi, Akinori Hosoya, Nisha Jose, Naoya Tsugawa, Yudai Kojima, Soichiro Yoshikawa, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe. Analysis of ileocecal immune response in an experimental colitis model using intra-vital imaging. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai

Naoya Tsugawa, Takashi Nagaishi, Taro Watabe, Akinori Hosoya, Nisha Jose, Yudai Kojima, Soichiro Yoshikawa, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe. Verification of immunoglobulin A regulation of mucosal microflora and homeostasis. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai

Kyoko Nishida, Akihiro Kimura, Takeshi Tsubata, Harumi Suzuki. NQO1 play a pathogenic role in autoimmune diseases through the suppression of IL-10 production in Th17 cells. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.12 Sendai

Takeshi Tsubata, Hongrui Yang, Chizuru Akatsu. CD72 recognizes RNA-related self-antigens and prevents autoimmunity. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.12 Sendai

Tsugawa Naoya, Nagaishi Takashi, Watabe Taro, Jose Nisha, Hosoya Akinori, Kojima Yudai, Yoshikawa Soichiro, Karasuyama Hajime, Adachi Takahiro, Watanabe Mamoru. 粘膜皮膚免疫(2)　粘膜の細菌叢とホメオスタシスに対する免疫グロブリンAによる制御の検証(Mucosal-Skin Immunity(2)　Verification of immunoglobulin A regulation of mucosal microflora and homeostasis). 日本免疫学会総会・学術集会記録 2017.12.01

Watabe Taro, Nagaishi Takashi, Hosoya Akinori, Jose Nisha, Tsugawa Naoya, Kojima Yudai, Yoshikawa Soichiro, Karasuyama Hajime, Adachi Takahiro, Watanabe Mamoru. 組織特異的免疫疾患(III)　実験的結腸炎モデルにおける生体内イメージングによる回盲免疫反応の分析(Tissue-specific immune diseases(III)　Analysis of ileocecal immune response in an experimental colitis model using intra-vital imaging). 日本免疫学会総会・学術集会記録 2017.12.01

Chizuru Akatsu, Amin Alborzian Deh Sheikh, Takeshi Tsubata. Role of CD45 (PTPRC) in the regulation of SHP-1 (PTPN6)-activating receptor CD22. The 3rd Japan-Taiwan Bilateral Conference on Protein Phosphatase 2017.11.19 Sendai

Chizuru Akatsu, Hongrui Yang and Takeshi Tsubata,. The Inhibitory B Cell Co-Receptor CD72 Regulates B Cell Response to Self Nucleic Acids Crucial for Development of SLE. Korean Association of Immunologists (KAI) International Meeting 2017 2017.11.10 Seoul

Takeshi Tsubata. Inhibitory B cell co-receptor and autoimmunity. Seoul National University School of Dentistry 2017.11.08 Seoul

Naoya Tsugawa, Takashi Nagaishi, Taro Watabe, Nisha Jose, Akinori Hosoya, Yudai Kojima, Takahiro Adachi, Richard S. Blumberg, Mamoru Watanabe. Verification of Immunoglobulin A regulation of microflora and protection of intestinal mucosa.. UEGW 2017 2017.10.31 Barcelona

Takeshi Tsubata. Inhibitory B cell co-receptor CD72 regulates self-tolerance through SHP-1 activation. University of Freiburg 2017.10.11 Freiburg, Germany

Nobutaka Numoto,Chizuru Akatsu,Kenro Shinagawa,Takeshi Tsubata,Nobutoshi Ito. Charge distribution regulates the ligand-binding affinity of B cell inhibitory receptor CD72. The 55th Annual Meeting of the Biophysical Society of Japan 2017.09.20 Kumamoto

Takashi Nagaishi, Taro Watabe, Nisha Jose, Akinori Hosoya, Yudai Kojima, Naoya Tsugawa, Takahiro Adachi, Mamoru Watanabe.. Deficiency of IgA Induces Microflora Alteration and Ileal Inflammation.. ICMI 2017 2017.07.21 Washington DC

MEDZHIDOV Nazim, TAKATA Toshitaro, SUZUKI Mitsuhiro, ICHINOSE Shizuko, TSUBATA Takeshi. Distinct ubiquitination level and sorting of the B cell receptor. The Regular Meeting of the Japanese Biochemical Society, Kanto Branch 2017 2017.06.17 Tokyo

Amin Alborzian-Deh-Sheikh, Chizuru Akatsu, Hideharu Ishida2, and Takeshi Tsubata. Cis-ligand dependent and independent interaction of receptor type protein tyrosine phosphatase CD45 with B cell inhibitory receptor CD22. The Regular Meeting of the Japanese Biochemical Society, Kanto Branch 2017 2017.06.17 Tokyo

Feng Yangyang, Rengarajan Sundararaman, Tang Miao, Tsubata Takeshi. Role of prolonged ROS in B cell receptor signaling. The Regular Meeting of the Japanese Biochemical Society, Kanto Branch 2017 2017.06.17 Tokyo

Akinori Hosoya, Takashi Nagaishi, Taro Watabe, Naoya Tsugawa, Nisha Jose, Yudai Kojima, Takahiro Adachi, Mamoru Watanabe. Verification of immunoglobulin A protection of intestinal mucosa from microflora. The 5th Annual Meeting of AOCC 2017.06.17 Seoul

Takashi Nagaishi, Taro Watabe, Nisha Jose, Akinori Hosoya, Yudai Kojima, Naoya Tsugawa, Takahiro Adachi, Mamoru Watanabe. IgA Deficiency Induces Spontaneous Inflammation in the Ileum. FOCIS 2017 2017.06.14 Chicago

Taro Watabe, Takashi Nagaishi, Akinori Hosoya, Nisha Jose, Arisa Tokai, Yudai Kojima, Takahiro Adachi, Mamoru Watanabe. The lack of secreted IgA spontaneously induces the mucosal inflammation specifically in the ileum. DDW (AGA) 2017.05.09 Chicago

Mohammad Aslam, Martin Weigert and Takeshi Tsubata. Regulation of self-reactive B cells by CD72 and Fas . 11th International Symposium of The Institute Network"Frontiers in Biomedical Sciences" 2017.01.26 Tokushima

ADACHI Takahiro, KARASUYAMA Hajime , YOSHIKAWA Soichiro. Visualization of immune responses by intravital imaging of Ca2+ signals. The 45th Annual Meeting of The Japanese Society for Immunology (JSI) 2016.12.07 OKINAWA

Medzhidov Nazim, Takata toshitaro, Suzuki Mitsuhiro, Ichinose Shizuko, Tsubata Takeshi. Distinct ubiquitination level and sorting of B cell receptor. The 45th Annual Meeting of The Japanese Society for Immunology (JSI) 2016.12.06 OKINAWA

TSUJI Noriko M, KAMIYA Tomonori, WATANABE yohei,KAKUTA Shigeru, ADACHI Takahiro. Effects of fermented food on immune response and gut microbiota of human faecal flora-associated (HFA) mice. The 45th Annual Meeting of The Japanese Society for Immunology (JSI) 2016.12.05 OKINAWA

Takeshi Tsubata. Development of a novel glycomimetic with unique immunological activity. . 15th Surugadai International Symposium　"Current Status and Future of Drug Discovery" 2016.11.29 TOKYO

Takeshi Tsubata. B lymphocytes and autoimmunity. Fudan University School of Basic Medical Sciences, China 2016.11.07 SHANGHAI,CHINA

Tsuji Noriko M., Kamiya Tomonori, Watanabe Yohei, Kakuta Shigeru, Adachi Takahiro. ヒト免疫学　正常・疾患時ヒト免疫のモデリング　ヒト糞便フローラ(HFA)マウスの免疫反応および腸内微生物叢に発酵食品が及ぼす効果(Human Immunology: modeling normal and diseased human immunity　Effects of fermented food on immune response and gut microbiota of human faecal flora-associated(HFA) mice). 日本免疫学会総会・学術集会記録 2016.11.01

Adachi Takahiro, Karasuyama Hajime, Yoshikawa Soichiro. 免疫記憶　Ca2+シグナルの生体内造影による免疫応答の可視化(Immunological memory　Visualization of immune responses by intravital imaging of Ca2+ signals). 日本免疫学会総会・学術集会記録 2016.11.01

Watabe Taro, Nagaishi Takashi, Jose Nisha, Tokai Arisa, Hosoya Akinori, Kojima Yudai, Adachi Takahiro, Watanabe Mamoru. 皮膚免疫と粘膜免疫1　腸管粘膜免疫応答の制御　マウスのIgA遺伝子座におけるCRISPR/Cas9を介した変異とその特徴(Skin & mucosal immunity: Regulation of intestinal mucosal immune responses　CRISPR/Cas9-mediated mutations in mouse IgA locus and its characterization). 日本免疫学会総会・学術集会記録 2016.11.01

Chizuru Akatsu,Kenro Shinagawa, Nobutaka Numoto, Zhihong Liu, Mohommad Aslam, Nobutoshi Ito, Takeshi Tsubata. B cells reactive to Sm/RNP, a lupus-related self-antigen. 12th International Conference on Protein Phosphatase (ICPP12) 2016.10.28 OSAKA

Kai Jin, Toshihiro Imada, Yusuke Izuta, Shigeru Nakamura, Takahiro Adachi, Kazuo Tsubota. IN VIVO VISUALIZATION OF Ca2+ DYNAMICS OF MYOEPITHELIAL CELLS IN LACRIMAL GLAND. 8th International Conference on the　Tea Film & Ocular Surface Basic Science and Clinical Relevance 2016.09.08 FRANCE

Tsubata, T.. B lymphocyte co-receptors and systemic lupus erythematosis. Fudan University 2015.12.16 Shainghai

Chizuru Akatsu, Mohammad Aslam, Takahiro Adachi, and Takeshi Tsubata . Interaction of CD72 and SLE-related antigen negatively regulates self-reactive B cells. The 44th JSI annual meeting 2015.11.20 Sapporo

Aslam, M., Adachi, T. and Tsubata, T.. CD72 regulates self-reactive B cells to nuclear antigens. The 44th Annual Meeting of The Japanese Society for Immunology 2015.11.20 Sapporo

Akatsu, C., Aslam, M., Adachi, T. and Tsubata, T.. Interaction of CD72 and SLE-related antigen negatively regulates self-reactive B cells. The 44th Annual Meeting of The Japanese Society for Immunology 2015.11.20 Sapporo

Onodera, T., Adachi, T., Tsubata, T., Ato, M. and Takahashi, Y.. Visualization of anti-nuclear Ab producing B cells by flow-cytometry in a SLE mouse model. The 44th Annual Meeting of The Japanese Society for Immunology 2015.11.18 Sapporo

Adachi Takahiro, Yoshikawa Soichiro, Karasuyama Hajime, Onodera Taishi, Takahashi Yoshimasa, Kikuta Junichi, Ishii Masaru, Tedder F. Thomas. 免疫記憶　Ca2+バイオセンサーYC3.60トランスジェニックマウスのリンパ球におけるCa2+シグナルの生体内イメージング(Immunological Memory　Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice). 日本免疫学会総会・学術集会記録 2015.10.01

Aslam Mohammad, Adachi Takahiro, Tsubata Takeshi. 全身性自己免疫性疾患(1)　CD72は核内抗原に対する自己反応性B細胞を制御する(Systemic autoimmune diseases(1)　CD72 regulates self-reactive B cells to nuclear antigens). 日本免疫学会総会・学術集会記録 2015.10.01

Onodera Taishi, Adachi Takahiro, Tsubata Takeshi, Ato Manabu, Takahashi Yoshimasa. 全身性自己免疫性疾患(1)　SLEマウスモデルにおけるフローサイトメトリーによる抗核Ab産生B細胞の可視化(Systemic autoimmune diseases(1)　Visualization of anti-nuclear Ab producing B cells by flow-cytometry in a SLE mouse model). 日本免疫学会総会・学術集会記録 2015.10.01

Tokai Arisa, Nagaishi Takashi, Watabe Taro, Jose Nisha, Yamazaki Motomi, Onizawa Michio, Suzuki Masahiro, Hosoya Akinori, Kawai Risa, Adachi Takahiro, Watanabe Mamoru. 皮膚と粘膜免疫の調節(2)　CD66aは活性化B細胞においてBCRシグナル伝達を調節する(Regulation of skin and mucosal immunity(2)　CD66a may regulate BCR signaling in the activated B cells). 日本免疫学会総会・学術集会記録 2015.10.01

Akatsu Chizuru, Aslam Mohammad, Adachi Takahiro, Tsubata Takeshi, Phoon S., Watanabe K., Shinagawa K., Ito N.. B細胞の生物学　CD72とSLE関連抗原の相互作用は自己反応性B細胞を負に調節する(B cell biology　Interaction of CD72 and SLE-related antigen negatively regulates self-reactive B cells). 日本免疫学会総会・学術集会記録 2015.10.01

Aslam, M., Adachi, T., Weigert, M. G. and Tsubata, T.. CD72 regulates self-reactive B cells to nuclear antigens. The 30th Autoimmune Conference 2015.07.11 Tokyo

Tsubata, T.. CD22-binding synthetic sialosides as a tool to elucidate the role of CD22 cis-ligand and as a novel immunostimulant. 2015.03.23 Freiburg

Tsubata, T.. CD22-binding synthetic sialosides as a tool to elucidate the role of CD22 cis-ligand and as a novel immunostimulant. TRR130 2015.03.18 Erlangen

Tsubata, T.. CD22-binding synthetic sialosides as a tool to elucidate the role of CD22 cis-ligand and as a novel immunostimulant. DRFZ 2015.03.16 Berlin

P. A. Koni., Ren, M., Tsubata, T., Khleif, S., Maverakis, E. and Shimoda, M.. A mouse model for chronic inflammatory diseases spontaneously develops CD4/CD8 double-positive T cell leukemia/lymphoma. . The 54th Midwinter Conference of Immunologists at Asilomar. 2015.01.24 Big Bear Lake, California (USA)

Adachi. T., Yoshikawa. S., Onodera. T., Takahashi. Y. and Karasuyama. H.. In vivo imaging of calcium signaling in B cells of mice expressing the genetically encoded YC3.60 calcium indicator. The 43rd Annual Meeting of the Japanese Society for Immunology 2014.12.08 Kyoto

Matsubara, N., Ishida, H. and Tsubata, T.. CD22-binding synthetic sialosides as a tool to elucidate the role of CD22 cis-ligand and as a novel immunostimulan. Medical Research Institute 40th Anniversary, 13th Surugadai International Symposium & Joint Usage/Research Program of Medical Research Institute International Symposium. 2014.11.28 Tokyo

Adachi. T., Yoshikawa. S., Onodera. T., Takahashi. Y. and Karasuyma. H.. In vivo imaging of calcium signaling in B cells of mice expressing the genetically encoded YC3.60 calcium indicator. The 37th Annual Meeting of the Molecular Biology Society of Japan 2014.11.26 Yokohama

Matsubara, N., Takematsu, H., Ishida, H., Tsubata, T.. Role of CD22/Siglec2 and its ligand in B lymphocyte activation. . Joint annual meeting of SFG &JSCR, Integrating Glycoscience from Biology and Chemistry to Medicine. 2014.11.16 Honolulu, Hawaii (USA)

Matsubara, N., Ishida, H. and Tsubata, T.. Synthetic sialosides that regulate CD22/Siglec-2, a B lymphocyte membrane molecule activating SH2-containing phosphatases.. 11th International Conference on Protein Phosphatase. 2014.11.12 Sendai

Adachi Takahiro, Yoshikawa Soichiro, Onodera Taishi, Takahashi Yoshimasa, Karasuyama Hajime. 免疫記憶　遺伝的にコード化されたYC3.60カルシウムインジケーターを発現するマウスのB細胞におけるカルシウムシグナル伝達のin vivo画像化(Immunological memory　In vivo imaging of calcium signaling in B cells of mice expressing the genetically encoded YC3.60 calcium indicator). 日本免疫学会総会・学術集会記録 2014.11.01

Yoshikawa Soichiro, Ohora Masatsugu, Miyake Kensuke, Li Lihua, Horiguchi Kayo, Ohta Takuya, Adachi Takahiro, Yamanishi Yoshinori, Karasuyama Hajime. 肥満細胞、好塩基細胞、好中球の細胞型特異的機能の調節機構　好塩基細胞におけるIgE/抗原刺激によるCa2+流入の根底にある分子機構(Regulatory mechanisms of cell type-specific functions of mast cells, basophils, and eosinophils　Molecular mechanism underlying Ca2+ influx due to IgE/antigen stimulation in basophils). 日本免疫学会総会・学術集会記録 2014.11.01

Onodera Taishi, Adachi Takahiro, Tsubata Takeshi, Kurosaki Tomohiro, Adachi Yu, Ato Manabu, Takahashi Yoshimasa. 発生中のB細胞調節の機構と免疫応答　インフルエンザワクチン接種後のCD273+免疫記憶B細胞は定常状態にある骨髄形質細胞を補充する(Mechanisms for B cell regulation during development and immune responses　CD273+ memory B cells replenish bone marrow plasma cells in the steady state after influenza vaccination). 日本免疫学会総会・学術集会記録 2014.11.01

Mohammad, A., Kishi Y., Weigert, M. G. and Tsubata, T.. Distinct tolerance mechanisms for anti-DNA and anti-Sm B cells.. The 29th Autoimmune Conference 2014.07.12

Li, Y., Hase, K., Tsubata, T. and Wang, J-Y.. Glia maturation factor-γ regulates marginal zone B cell migration and humoral immune responses.. Annual Meeting of the Japanese Society for Immunology 2013.12.11 Chiba.

Xu. M., Hou. R., Sato-Hayashizaki. A., Man. R-Y., Zhu. C., Wakabayashi. C., Hirose. S., Adachi. T. and Tsubata. T.. Cd72c is a modifier gene that regulates Faslpr-induced autoimmune disease.. Annual Meeting of the Japanese Society for Immunology 2013.12.11 Chiba.

Mohammad, A. and Tsubata, T.. Distinct tolerance mechanisms for anti-DNA and anti-Sm B cells. . Annual Meeting of the Japanese Society for Immunology 2013.12.11 Chiba.

Tsubata, T.. Regulation of B lymphocyte responses and sialic acid-binding immunoglobulin-like lectins (Siglecs). . Glyco Medicine Seminar, IBMS, Academia Sinica, 2013.11.27 Taipei.

Tsubata, T.. SHP-1-activating Receptors in B lymphocytes. . The 2nd Taiwan-Japan Bilateral Conference on Protein Phosphatase 2013.11.27 Hsinchu.

Xu Miduo, Hirose Sachiko, Adachi Takahiro, Tsubata Takeshi, Hou Rong, Sato-Hayashizaki Aya, Man Rongyong, Zhu Chenghua, Wakabayashi Chisato. Cd72cはFaslpr誘発性自己免疫疾患を調節する変更遺伝子である(Cd72c is a modifier gene that regulates Faslpr-induced autoimmune disease). 日本免疫学会総会・学術集会記録 2013.11.01

Onodera Taishi, Adachi Takahiro, Tsubata Takeshi, Kurosaki Tomohiro, Adachi Yu, Ato Manabu, Takahashi Yoshimasa. 長寿命形質細胞の動員は、インフルエンザワクチン接種後の維持期において、CD4+T細胞により恒常的に制限される(Replenishment of Long-Live Plasma Cells is constitutively restricted by CD4+T cells in their maintenance phase after influenza vaccination). 日本免疫学会総会・学術集会記録 2013.11.01

Adachi Takahiro, Yoshikawa Soichiro, Karasuyama Hajime, Onodera Taishi. 遺伝的にコード化されたYC3.60カルシウムインジケータを発現するマウスのB細胞におけるカルシウムシグナル伝達のin vivoイメージング(In vivo imaging of calcium signaling in B cells of mice expressing the genetically encoded YC3.60 calcium indicator). 日本免疫学会総会・学術集会記録 2013.11.01

Yoshikawa Soichiro, Oh-hora Masatsugu, Miyake Kensuke, Li Lihua, Ohta Takuya, Adachi Takahiro, Horiguchi Kayo, Kawano Yohei, Karasuyama Hajime. STIM1介在性のストア作動性Ca2+流入はIgEによる慢性アレルギー性炎症における好塩基球動員に必須である(STIM1-mediated store operated Ca2+ entry is essential for basophil recruitment in IgE-mediated chronic allergic inflammation). 日本免疫学会総会・学術集会記録 2013.11.01

Tsubata, T.. Sialic acids and immune responses. Molecular Frontier Science Conference for Humboltians and DAAD Alumni 2013.09.20 上海

Shimoda. M., Bolduc. A., Takezaki. M., Tsubata. T. and Koni. P-A. . Excess B cell CD40/CD40L signaling promotes CD4 T cell-mediated encephalomyelitis in mice. . Immunology 2013 AAI Annual meeting. 2013.05.03 Honolulu.

Tsubata, T.. CD72c a hapolotype encoding the SHP-1-binding B lymphocyte molecule is a modifier gene for murine lupus. the 10th International Conference on Protein Phosphatase 2013.02.07 東京

Tsubata, T.. CD72C , a hapolotype encoding the SHP-1-binding B lymphocyte molecule, is a modifier gene for murine lupus. the 10th International Conference on Protein Phosphatase 2013.02.07 東京

Tang, M., Takata, T., Tsubata, T.. Time, place and pathway-specific involvement of reactive oxygen species in B cell antigen receptor signaling. . 日本免疫学会学術総会 2013.02.05 神戸

Watanabe Kozo, Adachi Takahiro, Tsubata Takeshi. B細胞活性化制御とシグナル　C型レクチン様ドメインを持つB細胞膜タンパク質CD72はスルファチドを認識し、抗スルファチド抗体産生を制御する(The C-type lectin-like domain containing B lymphocyte membrane protein CD72 recognizes sulfatide and regulates anti-sulfatiide antibody production). 日本免疫学会総会・学術集会記録 2012.11.01

Yoshikawa Soichiro, Egawa Mayumi, Oh-hora Masatsugu, Adachi Takahiro, Horiguchi Kayo, Li Lihua, Ohta Takuya, Kawano Yohei, Minegishi Yoshiyuki, Karasuyama Hajime. 炎症応答におけるマスト細胞と顆粒球の機能　STIM1はIgEを介する慢性アレルギー性炎症時の好塩基球動員において重要な役割を果たす(STIM1 plays an essential role in basophil recruitment during IgE-mediated chronic allergic inflammation). 日本免疫学会総会・学術集会記録 2012.11.01

Adachi Takahiro, Yoshikawa Soichiro, Karasuyama Hajime. 記憶T細胞とB細胞　遺伝的にコードされたカルシウム指示分子YC3.60レポーターマウス系におけるB細胞活性のin vivoイメージング(In vivo imaging of B cell activity in a genetically encoded calcium indicator YC3.60 reporter mouse line). 日本免疫学会総会・学術集会記録 2012.11.01

Suganuma, Y., Matsubara, N., Iwayama, Y., Ueki, A., Imamura, A., Ando, H., Tsubata, T., Ishida, H. and Kiso, M.. Synthesis and biological evaluation of the mimics of cis ligand for CD22. The 4th Asian Communication for Glycobiology and Glycotechnology (ACGG) 2012.10.28 Jeju, Korea

Tsubata, T.. Screening of chemical compounds that regulate antibody responses. . 中国医学科学院/北京協和医科大学 2012.03.14 北京、中国

Tsubata, T.. Molecular and Cellular aspects of Autoimmune Diseases. . 中国医科大学 2012.01.09 瀋陽、中国

Tang Miao、高田俊太朗、鍔田武志. Role of Reactive Oxygen Species in B Cell Antigen Receptor Signaling. 第40回日本免疫学会学術集会 2011.11.27 幕張

Matsunaga Syu, Takahashi Ken, Sakuramoto Masateru, Taguchi Jun, Adachi Takahiro, Hashimoto Kahoko. 抗原提示　プロフェッショナル抗原提示細胞におけるSec8分子の機能解析(The functional analysis of Sec8 molecules on professional antigen presenting cells). 日本免疫学会総会・学術集会記録 2011.11.01

Adachi Takahiro. B細胞免疫記憶　記憶B細胞における抗原受容体を介したシグナリング(Signaling through the antigen receptor on memory B cell). 日本免疫学会総会・学術集会記録 2011.11.01

Watanabe Kozo, Adachi Takahiro, Tsubata Takeshi. B細胞免疫反応の制御機構　B細胞特異的C型レクチン様分子CD72の硫酸化糖に対するCa2+非依存性のレクチン活性(The C-type lectin-like domain containing B lymphocyte membrane molecule CD72 shows Ca2+-independent lectin activity to sulfated glycans). 日本免疫学会総会・学術集会記録 2011.11.01

Tsubata, T.. Development of chemial compounds that regulate specific antibody production.. 中国医学科学院/北京協和医科大学 2011.03.17 北京、中国

Tsubata, T.. Apoptotic deletion of self-reactive B cells in the splenic marginal zone. . The Gwen Knapp Symposium “the Antigen Targets of Autoimmune Disease”, The University of Chicago 2010.10.08 Chicago, USA.

Tsubata, T.. Excess CD40L and autoimmunity.. Immunotherapy Center, Medical College of Georgia 2010.10.06 Augusta, USA.

Tsubata, T.. Apoptotic deletion of marginal zone B cells: a novel tolerance mechanism of pathogenic self-reactive B cells.. Deutsches Rheuma-Forschungszentrum Berlin (DRFZ) 2010.10.04 Berlin, Germany.

Tsubata, T.. Control of infectious diseases by functional modulation of B lymphocytes. . The 8th German-Japanese Immunology Symposium ”Regulation of Immune Response and Disease” 2010.09.26 Cuxhaven, Germany.

Tsubata, T.. Membrane-bound lectins and humoral immunity. International Summer Program 2010 ”Infection and Immunity”, Tokyo Medical and Dental University 2010.09.05 Tokyo.

Kishi, Y., Higuchi, T., Sakamaki, Y., Tsubata, T.. Overexpression of CD40L (CD154) breaks down self-tolerance in spleen in autoantibody-transgenic mice. . 14th International Congress of Immunology 2010.08.22 Kobe

Man, R.-Y., Onodera, T., Komatsu, E., Tsubata, T.. Augmented B Lymphocyte Response to Antigen in the Absence of Antigen-Induced B lymphocyte Signaling in an IgG-Transgenic Mouse Line. . 14th International Congress of Immunology 2010.08.22 Kobe

Hou, R., Sato, A., Lin, Q., Ohtsuji, M., Adachi, T., Hirose, S., Tsubata, T.. Effect of CD72c allotype on SLE susceptibility.. 15th International Congress of Immunology 2010.08.22 Kobe

Abdu-Allah, H. H. M., Ishida, H., Tsubata, T., Kelm, S., Paulson, J. C., Ando, H., Kiso, M.. Design and Synthesis of Novel Sialosides as potent and selective CD22-Inhibitors. . Sialoglyco Meeting 2010 2010.08.21 Potsdam, Germany.

Tsubata, T.. Control of Infectious Diseases by Functional Modulation of B Lymphocyte Lectins. . The 28th Naito Conference on ”Glycan Expression and Regulation [I]:Functions and Disease Mechanisms” 2010.07.27 Kanagawa.

Tsuiji. M., Tanaka. M., Imai. N., Hayashizaki. K., Tsubata. T.. The Immune Response against Capsular Polysaccharides of Streptococcus pneumoniae. . The 28th Naito Conference on ”Glycan Expression and Regulation [I]:Functions and Disease Mechanisms” 2010.07.27 Kanagawa.

Miduo Xu, Rong Hou, Mareki Ohtsuji, Naomi Ohtsuji, Takahiro Adachi, Sachiko Hirose, Takeshi Tsubata. CD72 modulates the development of lupus-like disease in B61pr/pr mice. 第39回日本免疫学会 2009.12.02 大阪

Rong Hou, Mareki Ohtsuji, Naommi Ohtsuji, Li Zhang, Takahiro Adachi, Sachiko Hirose, Takeshi Tsubata. Centromeric interval of chromosome4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD.CD72b congenic mice. 第39回日本免疫学会 2009.12.02 大阪

Man Rong-Yong, Taishi Onodera, Takeshi Tsubata. Ligand-independent high tonic signaling through IgG-BCR induces B-cell receptor signaling defect and enhances B cell response. 第39回日本免疫学会 2009.12.02 大阪

満栄勇、小野寺大志、鍔田武志. Increased tonic B cell antigen receptor signaling but reduced antigen-induced B cell response in transgenic B cells expressing IgG. 第38回日本免疫学会総会・学術集会 2009.12.01 京都

Tsubata, T.. B cell response augmentation by expression of IgG and deficiency in CD22. Annual Symposium of the Korean Association of Immunologists 2009.11.09 Seoul, Korea

Xu Miduo, Hou Rong, Ohtsuji Mareki, Ohtsuji Naomi, Adachi Takahiro, Hirose Sachiko, Tsubata Takeshi. 全身性自己免疫疾患　素因、病態、治療　CD72はB6lpr/lprマウスにおけるループス様疾患の形成を制御する(CD72 modulates the development of lupus-like disease in B6lpr/lpr mice). 日本免疫学会総会・学術集会記録 2009.11.01

Sato Aya, Hou Rong, Lin Qingshun, Ohtsuji Mareki, Adachi Takahiro, Hirose Sachiko, Tsubata Takeshi. 全身性自己免疫疾患　素因、病態、治療　CD72遺伝子多型と自己免疫疾患との関連(Role of CD72 polymorphism for autoimmune disease). 日本免疫学会総会・学術集会記録 2009.11.01

Hou Rong, Ohtsuji Mareki, Ohtsuji Naomi, Zhang Li, Adachi Takahiro, Hirose Sachiko, Tsubata Takeshi. 臓器特異的自己免疫疾患　C56BL/6由来の第四染色体セントロメア近傍の遺伝子による糖尿病の亢進(Centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD.CD72b congenic mice). 日本免疫学会総会・学術集会記録 2009.11.01

Adachi Takahiro. 記憶細胞の発達と活性化　記憶B細胞における抗原受容体を介したシグナリングの解析(Analysis of signaling through the B cell antigen receptor in memory B cells). 日本免疫学会総会・学術集会記録 2009.11.01

Tsubata, T.. Inhibitory B lymphocyte co-receptor CD72 and autoimmunity. C. M. U. (ジュネーブ大学医療センター) 2009.09.18 Geneva, Switzerland

Tsubata, T.. Membrane-bound lectins and humoral immunity. 2ndEuropean Congress of Immunology 2009.09.13 Berlin, Germany

N. Engels, L. M. Koening, C. Heemann, J. Lutz, Tsubata, T., S.Griep, V. Schrader, J. Wienands. The immunoglobulin tail tyrosine of surface IgG and IgE provides antigen receptor-intrinsic costimulation to class-switched B cells. 2ndEuropean Congress of Immunology 2009.09.13 Berlin, Germany

Tsubata, T.. How unresponse, slow response and rapid response of humoral immunity is determined? . ZIBI　International Summer School on Pathogen-Host-Interplay 2009.07.19 Berlin,　Germany

Tsubata, T.. Membrane-bound lectins and humoral immunity. CREST International Symposium “Acquired Immunity and Glycobiology” 2009.03.23 Kazusa, Japan

Wtanabe, K., Tsuchiya, Y., Kawaguchi, Y., Ayame, H., sawada, S., Akiyoshi, K., Tsubata, T.. Self-assembled cationic nanogel-mediated efficient protein delivery in mouse primary T cells. The 5th international Workshop of Kyoto Tcell conference 2009.01.01 Kyoto, Japan

Tsubata, T.. Molecular and cellular aspects of antibody production and its abnormality. China Medical University 2008.11.27 Shenyang, China

Tsubata, T.. Cell death, autophagy, cell senescence and their roles in diseases. 7th Surugadai International Symposium 2008.11.16 Tokyo

渡辺 幸造, 中島 権一, 今井 有香, 安達 貴弘, 佐藤 元彦, 林崎 浩史, 戸谷 希一郎, 伊藤 幸成, 鍔田 武志. B細胞特異的C型レクチン様分子CD72はオリゴマンノースに対してCa2+非依存性のレクチン活性を有する(Ca2+ independent lectin activity of C-type lectin-like domain-containing B lymphocyte membrane molecule CD72 for oligomannose). 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 2008.11.01

Watanabe Kozo, Adachi Takahiro, Tsubata Takeshi. B細胞分化とその活性化シグナル　B細胞特異的C型レクチン様分子CD72のオリゴマンノースに対するCa2+非依存性のレクチン活性(The C-type lectin-like domain-containing B lymphocyte membrane molecule CD72 carries a Ca2+-independent lectin activity to oligomannose). 日本免疫学会総会・学術集会記録 2008.11.01

Hitomi Yuki, Adachi Takahiro, Iwai Yoshiko, Tsuchiya Naoyuki, Honda Zen-ichiro, Tokunaga Katsushi, Tsubata Takeshi. B細胞分化とその活性化シグナル　SLE抵抗性を有するヒトCD72選択的スプライシングアイソフォームは小胞体ストレスによるアポトーシスを惹起する(Augmentation of ER stress-induced apoptosis by the alternatively spliced isoform of human CD72 responsible for resistance of individuals with CD72*2 to systemic lupus erythematosus). 日本免疫学会総会・学術集会記録 2008.11.01

Adachi Takahiro, Man Rong-Yong, Yakura Hidetaka, Tsubata Takeshi. B細胞分化とその活性化シグナル　CD22による糖鎖リガンド依存的および非依存的なB細胞抗原受容体シグナル伝達制御(Glycan ligand-dependent and -independent regulation of the B cell antigen receptor signaling by CD22). 日本免疫学会総会・学術集会記録 2008.11.01

Tsubata, T.. Endoplasmic reticulum stress and autoimmune diseases. Kongress der Deutschen Gesellschaft fur Rheumatologie 2008.09.24 Berlin, Germany

Tsubata, T.. Regulation of the B cell response by BCR and its co-receptors: Idling BCR engine model. Georg August University of Goettingen 2008.09.23 Goettingen, Germany

Tsubata, T.. Regulation of the B cell response by BCR and its co-receptors: Idling BCR engine model. Nikolaus Fiebiger Centre for Molecular Medicine, University of Erlangen-Nurnberg 2008.09.17 Erlangen, Germany,

Tsubata, T.. Regulation of the time course of B cell response by BCR and its co-receptors. Deutsches Rheuma-Forschungszentrum 2008.09.01 Berlin, Germany,

Tsubata, T.. Regulation of the B cell response by BCR and its co-receptors. MPI Immunobiology 2008.08.25 Freiburg, Germany,

Tsubata, T.. Functional role of inhibitory BCR co-receptors CD22 and CD72. 1st International Singapore symposium of immunology 2008.01.14 Singapore

Yu, J., Adachi, T., Gao, X., Takematsu, H., Tsubata, T. . 合成糖鎖リガンドによるＣＤ２２のＢ細胞受容体とのリピッドラフトでの共局在の阻害/ Synthetic glycan ligand excludes CD22 from antigen receptor-containing lipid rafts. . 第37回日本免疫学会総会・学術集会 2007.11.20 東京

Yan, B., Adachi, T., Tsubata, T.. 小胞体ストレスがＢ細胞抗原受容体を介したアポトーシスに関与する/ Unfolded protein response is involved in B cell antgen receptor-mediated apoptosis.. 第37回日本免疫学会総会・学術集会 2007.11.20 東京

Zhu, C., Adachi, T., Sato, M., Fujimoto, M., Tsubata, T. . An ITAM-like motif containing tyrosine 817 in CD22 together with an ITIM containing tyrosine 783 is sufficient for negative regulation of BCR signaling. . 第37回日本免疫学会総会・学術集会 2007.11.20 東京

戸田 宗豊, 圓山 浩二, 万木 肇, 秋田 薫, 井上 瑞江, 竹内 紀子, 安達 貴弘, 鍔田 武志, 中田 博. 腫瘍産生性ムチンとCD22との連鎖反応は脾臓辺縁帯B細胞を劇的に障害する(Ligation of tumor-produced mucin to CD22 dramatically impairs splenic marginal zone B cells). 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 2007.11.01

Zhu Chenghua, Adachi Takahiro, Sato Motohiko, Fujimoto Manabu, Tsubata Takeshi. CD22におけるITIM含有チロシン783とチロシン817を含有するITAMモチーフはBCRシグナル伝達の負制御に十分である(An ITAM-like motif containing tyrosine 817 in CD22 together with an ITIM containing tyrosine 783 is sufficient for negative regulation of BCR signaling). 日本免疫学会総会・学術集会記録 2007.10.01

Adachi Takahiro, Yu Jie, Onodera Taishi, Man Rong-Yong, Tsubata Takeshi. CD22によるアイソタイプ特異的抗原受容体シグナル伝達制御には多価の蛋白質抗原が必要である(CD22-mediated isotype specific B cell antigen receptor signaling regulation requires multivalent hapenated antigen). 日本免疫学会総会・学術集会記録 2007.10.01

Hitomi Yuki, Adachi Takahiro, Tsuchiya Naoyuki, Honda Zen-ichiro, Tokunaga Katsushi, Tsubata Takeshi. 全身性エリテマトーデスに対する耐性を付与するヒトCD72の選択的スプライシングアイソフォームはB細胞アポトーシスを制御する(The alternative spliced isoform of human CD72 that confer resistant against systemic lupus erythematosus regulate B lymphocyte apoptosis). 日本免疫学会総会・学術集会記録 2007.10.01

Yan Bincheng, Adachi Takahiro, Tsubata Takeshi. 小胞体ストレスがB細胞抗原受容体を介したアポトーシスに関与する(Unfolded protein response is involved in B cell antigen receptor-mediated apoptosis). 日本免疫学会総会・学術集会記録 2007.10.01

Yu Jie, Adachi Takahiro, Gao Xiaoming, Takematsu Hiromu, Tsubata Takeshi. 合成糖鎖リガンドによるCD22のB細胞受容体とのリピッドラフトでの共局在の阻害(Synthetic glycan ligand excludes CD22 from antigen receptor-containing lipid rafts). 日本免疫学会総会・学術集会記録 2007.10.01

Mohamed, A, A, H, H., Tsubata, T., Ishida, H. and Kiso, M. . Design and synthesis of novel sialosides as potential CD22-specific inhibitors. . XIX International Symposium on Glycoconjugates. (Glyco-19) 2007.07.15 Cairns, Australia.

A, A, H, H, Mohamed., Tsubata, T., Ishida, H. and Kiso, M.. Design and synthesis of novel sialosides as potential CD22-specific inhibitors. . The 2nd Annual meeting of Japanese society for chemical biology 2007.05.09 Kyoto

Yu, J. and Tsubata, T.. 糖鎖リガンド類似化合物によるBリンパ球活性化制御分子CD22の機能制御. 日本ケミカルバイオロジー研究会第２回年会 2007.05.09 京都

Tsubata, T.. Functional role of inhibitory BCR Co-receptors CD22 and CD72. . 1st International Singapore Symposium of Immunology. 2007.01.12 Biopolis, Singapore.

Zhu C, Sato M, Fujimoto M and Tsubata T. . The signal immunoreceptor tyrosine-based inhibition motif containing the tyrosine 783 in CD22 is sufficient for negative regulation of BCR signaling.. 第36回日本免疫学会総会学術集会 2006.12.11 大阪

Yu J, Adachi T, Gao X, Tsubata T.. Establishment of the screening for mouse CD22 inhibitors. . 第36回日本免疫学会総会学術集会 2006.12.11 大阪

厳斌成、安達貴弘、鍔田武志. B細胞抗原受容体を介したアポトーシスにおけるROSの役割. 第36回日本免疫学会総会学術集会 2006.12.11 大阪

Adachi Takahiro, Yan Bincheng, Tsubata Takeshi. アポトーシス　B細胞において細胞周期停止はROS介在性アポトーシスを誘導する(Cell cycle arrest induces ROS-mediated apoptosis in B cells). 日本免疫学会総会・学術集会記録 2006.11.01

Tsubata Takeshi, Yu Jie, Sato Motohiko, Onodera Taishi, Wakabayashi Chisato, Adachi Takahiro. 免疫認識、シグナル伝達、及びイメージング　B細胞表面上のBCR共受容体CD22及びCD72の制御された局在(Immune recognition, signaling and imaging　Regulated localization of BCR co-receptors CD22 and CD72 on the B cell surface). 日本免疫学会総会・学術集会記録 2006.11.01

Yu Jie, Adachi Takahiro, Gao Xiaoming, Tsubata Takeshi. B細胞の分化・活性化と情報伝達　B細胞活性化を制御する細胞内シグナル　マウスCD22阻害因子のスクリーニング法の確立(Establishment of the screening for mouse CD22 inhibitors). 日本免疫学会総会・学術集会記録 2006.11.01

Tsubata, T.. Immunoglobulin isotype-dependent regulation of B cell antigen receptor signaling mediated by Siglec2/CD22. . The 5th Sialoglycoscience 2006 International Conference 2006.08.27 Mishima

Sato Motohiko, Wakabayashi Chisato, Hokazono Yasuhisa, Onodera Taishi, Adachi Takahiro, Tsubata Takeshi. siglec2/CD22を介するB細胞抗原受容体信号伝達の免疫グロブリンイソ型依存性調節(Immunoglobulin Isotype-Dependent Regulation of B Cell Antigen Receptor Signaling Mediated by Siglec2/CD22). Trends in Glycoscience and Glycotechnology 2006.08.01

The single immunoreceptor tyrosine-based inhibition motif surrounding the tyrosine 783 in CD22 (siglec2) is sufficient for negative regulation of BCR signaling. 20th IUBMB International Congless of Biochemistry and Molecular Biology and 11th FAOBMB Congress. 2006.06.18 Kyoto 2006.06.18

Toda M, Takeuchi N, Inoue M, Adachi T, Matsubara J, Taketani S, Tsubata T, Murata T and Nakada H.. Immunosuppressive effect of mucin on B cell function in tumor-bearing state. . 20th IUBMB International Congless of Biochemistry and Molecular Biology and 11th FAOBMB Congress. 2006.06.18 Kyoto

Zhu C, Tsubata T and Adachi T. . The single immunoreceptor tyrosine-based inhibition motif surrounding the tyrosine 783 in CD22 (siglec2) is sufficient for negative regulation of BCR signaling.. 20th IUBMB International Congless of Biochemistry and Molecular Biology and 11th FAOBMB Congress. 2006.06.18 Kyoto

厳斌成、安達貴弘、鍔田武志. B細胞抗原受容体を介したアポトーシスにおけるROSの解析. 日本ケミカルバイオロジー研究会第一回年会 2006.05.08 東京

于潔、澤田敏彦、安達貴弘、Xiaoming Gao, 石田秀治、木曾真、鍔田武志. マウスCD22阻害剤のスクリーニング系の構築. 日本ケミカルバイオロジー研究会第一回年会 2006.05.08 東京

Tsubata, T.. B cell tolerance and autoimmunity. . FIMSA/IIS Advanced Course on Immunology 2006.03.01 New Delhi, India

mmunosuppressive effect of mucin on B cell function in tumor-bearing state.. . 20th IUBMB International Congless of Biochemistry and Molecular Biology and 11th FAOBMB Congress. 2006

安達 貴弘. Screening of the genes related to the cell cycle arrest-induced apoptosis... International Symposium on Life of Proteins 2005.10.30 Awajishi 2005.10.30

Adachi, T., Bin-Cheng Yan., Tsubata, T.. Screening of the genes related to the cell cycle arrest-induced apoptosis. . International Symposium on Life of Proteins 2005.10.30 Awajishi

Akagawa Mitsugu, Ito Sohei, Takasaki Yoshinari, Hattori Nobutaka, Adachi Takahiro, Matuda Tsukasa, Uchida Koji. タンパク質に結合した脂質過酸化物は全身性紅斑性狼瘡の特徴である抗DNA自己抗体の標的となる(Protein-bound lipid peroxidation products are targeted by anti-DNA autoantibodies, the hallmark of systemic lupus erythematosus). 生化学 2005.08.01

Toda Munetoyo, Takeuchi Noriko, Adachi Takahiro, Nakanishi Katsuyuki, Matsubara Jyunko, Taketani Shigeru, Tsubata Takeshi, Murata Takeomi, Nakada Hiroshi. 担ガン状態におけるB細胞機能に対するムチンの免疫抑制効果(Immunosupressive effect of mucin on B cell function in tumor-bearing state). 生化学 2005.08.01

Tsubata, T.. Cell cycle control of lymphocyte apoptosis. . Conference on “Cell Death, Cell Cycle and Cell Senescence” 2004.11.17 Kisarazu,

Tsubata, T.. Molecular switches regulating activation of naive and memory B lymphocytes. The Japan-China Cooperative Life Science Symposium in Kumamoto 2004.11.12 Kumamoto

Tsubata, T.. Molecular switches governing activation of naive and memory B lymphocytes.. National Center for AIDS/STD Control and Prevention (NCAIDS) 2004.09.22 Beijing

鍔田武志. Molecular switches determining activation vs. apoptosis of antigen-stimulated B lymphocytes. 理化学研究所和光本所 2004.09.02 和光市

Satoh Motohiko, Adachi Takahiro, Wakabayashi Chisato, Tsubata Takeshi. 免疫グロブリンアイソタイプの違いによるB細胞反応性の差異におけるSiglec-2/CD22の役割(Role of Siglec-2/CD22 in class-specific regulation of B lymphocyte activation). 生化学 2004.08.01

Tsubata, T.. Isotype-specific regulation of B lymphocyte activation by siglec 2/CD22.. 21st International Lectin Meeting 2004.05.23 Shonan

Tsubata, T.. The level of c-Myc determines survival vs. apoptosis upon cell cycling.. UK-Japan Cell Cycle Workshop 2004.05.13 Nara

Wakabayashi Chisato, Adachi Takahiro, Sato Motohito, Hokazono Yasuhisa, Tsubata Takeshi. siglec 2/CD22によるBリンパ球活性化のアイソタイプ特異的調節(Isotype-Specific Regulation of B Lymphocyte Activation by Siglec 2/CD22). Trends in Glycoscience and Glycotechnology 2004.05.01

Tsubata, T.. From BCR signal regulation to better vaccination strategies. . China-Japan Planning Meeting for Cooperative Study on SARS 2004.02.21 Tokyo

Tsubata, T.. Immunoglobulin isotype-specific regulation of B cell antigen receptor signaling. Keystone Symposia 2004.01.08 Steamboat Springs

Adachi, T., Hokazono, Y., Matthias Wabl, Tsubata, T.. Inhibitory co-receptors activated by antigens but not by Anti-immunoglobulin heavy chain antibodies Install requirement of co-stimulation through CD40 for survival and proliferation of B cells. Keystone Symposia 2004 “Lymphocyte activation and signaling” 2004.01.08 Steamboat Springs

Tsubata, T.. Immunoglobulin isotype-specific regulation of B cell antigen receptor signaling.. Keystone Symposia 2004 “Lymphocyte activation and signaling” 2004.01.08 Steamboat Springs

Tsubata, T.. Regulation of antigen receptor signaling in B lymphocytes –Towards understanding of the molecular basis of vaccination-. . Symposium “From Genome Science to Medicine” 2003.11.29 東京

Tsubata, T.. Regulation of B lymphocyte activation by inhibitory BCR co-receptors CD22 and CD72. University of Bielefeld, 2003.11.11 Bielefeld

Tsubata, T.. Immunoglobulin isotype-specific regulation of B cell antigen receptor signaling. . Joint Meeting of STS and FZI 2003.11.06 Weimar

Tsubata, T.. Regulation of B lymphocyte activation by inhibitory BCR co-receptors CD22 and CD72. DRFZ 2003.11.04 Berlin

Hirai Hiroyuki, Adachi Takahiro, Tsubata Takeshi. CDK阻害剤の発現により誘導されたアポトーシスをc-Mycは制御する(c-Myc regulates apoptosis induced by expression of a CDK inhibitor). 生化学 2003.08.01

Wakabayashi Chisato, Adachi Takahiro, Tsubata Takeshi. 免疫細胞活性化・分化のシグナル伝達とその制御　Immunoglobulin Isotype特異的シグナリング経路を制御するBリンパ球の活性化(Signal transduction regulating activation and differentiation of immune cells: Immunoglobulin isotype-specific signaling pathway regulating B lymphocyte activation). 生化学 2003.08.01

Adachi Takahiro, Wakabayashi Chisato, Tsubata Takeshi. Bリンパ球活性化のクラス特異性制御におけるSiglec-2/CD22 の役割(Role of Siglec-2/CD22 in class-specific regulation of B lymphocyte activation). 生化学 2003.08.01

Tsubata, T.. CD40 signaling perturbs peripheral deletion of self-reactive B cells.. Workshop on the Genetics and Mechanisms of Autoimmunity, Princeton 2003.03.21 Princeton

饗場祐一、樋口哲也、西岡清、鍔田武志. CD40リガンドの異所性発現による末梢B細胞トレランス破綻機構の解析　. 第36回日本免疫学会総会 2002.12.04 東京

Y. Aiba, T. Higuch and T. Tsubata . Role of CD40 signaling in selection and maturation of B cells in vivo . 12th KTCC 2002.08.03 京都

Tsubata Takeshi, Adachi Takahiro, Wakabayashi Chisato, Higuchi Tetsuya, Aiba Yuichi. B細胞に関する共受容体及び補助的刺激受容体による液性免疫反応の調節(Regulation of humoral immune responses by co-receptors and costimulatory receptors on B cells). 日本免疫学会総会・学術集会記録 2001.12.01

Hirai Hiroyuki, Adachi Takahiro, Tsubata Takeshi. サイクリンキナーゼ阻害剤Kip1とc-MycのBリンパ球アポトーシスにおける役割(ROLE OF CKI KIP1 AND C-MYC IN B LYMPHOCYTES APOPTOSIS). Cell Structure and Function 2001.10.01

Tsubata ,T.. CD40 signaling abrogates clonal deletion of dsDNA-reactive B cells and induces lupus-like autoimmune disease.. The 7th International Workshop on Autoantibodies and Autoimmunity. 2001.09.26 Awaji

Tsubata, T., Aiba, Y., Higuchi, T., Furukawa, k., Honjo, T.. CD40 signaling regulates selection of selfreactive B cells and maturation of gerninal center B cells in vivo. . 11th international congress of immunology. 2001.07.22 Stockholm,

Tsubata ,T.. Regulation of self-reactive B cells by CD40 signaling.. 17th DGfI spring meeting. 2001.01.21 Innsbruck

Tsubata, T.. Studies on B cell selection in CD40 ligand-transgenic mice.. South Florida University 2001.01.18 USA

Tsubata, T.. Studies on B cell selection in CD40 ligand-transgenic mice.. Duke University 2001.01.17 USA

Tsubata ,T., Higuchi,T., Aiba, Y., Honjo, T., and Martin Weigert. . Ectopic expression of CD40L on B cells abrogates self-tolerance and induces lupus-like autoimmune disease. . Keystone Symposia, Regulation of Immunity and Autoimminity. 2001.01.10 Keystone,

Aiba, Y., Higuchi, T., Takamori, T., Honjo,T., and Tsubata, T.. Transgenic expression of CD40 ligand promotes maturation of germinal center B cells in vibvo. Keystone Symposia. Regulation of Immunity and Autoimminity. 2001.01.10 Keystone,

Tsubata Takeshi, Wakabayashi Chisato, Wienands Juergen, Yakura Hidetaka, Reth Michael, Adachi Takahiro. Bリンパ球の抑制性Co-receptors. 日本免疫学会総会・学術集会記録 1999.10.01