神経病理学分野

40  件  
※ 登録方法の違いにより重複して表示されている場合があります。

  1. Gall-Duncan T, Luo J, Jurkovic CM, Fischer LA, Fujita K, Deshmukh AL, Harding RJ, Tran S, Mehkary M, Li V, Leib DE, Chen R, Tanaka H, Mason AG, Lévesque D, Khan M, Razzaghi M, Prasolava T, Lanni S, Sato N, Caron MC, Panigrahi GB, Wang P, Lau R, Castel AL, Masson JY, Tippett L, Turner C, Spies M, La Spada AR, Campos EI, Curtis MA, Boisvert FM, Faull RLM, Davidson BL, Nakamori M, Okazawa H, Wold MS, Pearson CE: Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability. Cell. 2023.10; 186 (22): 4898-4919.e25. ( PubMed , DOI )

  2. Fujita K, Homma H, Jin M, Yoshioka Y, Jin X, Saito Y, Tanaka H, Okazawa H: Mutant α-synuclein propagates via the lymphatic system of the brain in the monomeric state. Cell Rep. 2023.08; 42 (8): 112962. ( PubMed , DOI )

  3. Jin X, Tanaka H, Jin M, Fujita K, Homma H, Inotsume M, Yong H, Umeda K, Kodera N, Ando T, Okazawa H: PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions. Nat Commun. 2023.01; 14 (1): 9. ( PubMed , DOI )

  1. Tanaka H, Okazawa H: PQBP1: The Key to Intellectual Disability, Neurodegenerative Diseases, and Innate Immunity. Int J Mol Sci. 2022.06; 23 (11): 6227. ( PubMed , DOI )

  2. Shiwaku H, Katayama S, Kondo K, Nakano Y, Tanaka H, Yoshioka Y, Fujita K, Tamaki H, Takebayashi H, Terasaki O, Nagase Y, Nagase T, Kubota T, Ishikawa K, Okazawa H, Takahashi H: Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice. Cell Rep Med. 2022.04; 3 (4): 100597. ( PubMed , DOI )

  1. Okazawa H, Tanaka H: Molecular Dissection and Therapeutic Application of SCA1 Pathologies Revealed by Comprehensive Approaches. Cerebellum as a CNS Hub. 2021.11; 479-486.

  2. Jin M, Shiwaku H, Tanaka H, Obita T, Ohuchi S, Yoshioka Y, Jin X, Kondo K, Fujita K, Homma H, Nakajima K, Mizuguchi M, Okazawa H: Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation. Nat Commun. 2021.11; 12 (1): 6565. ( PubMed , DOI )

  3. Tanaka H, Kondo K, Fujita K, Homma H, Tagawa K, Jin X, Jin M, Yoshioka Y, Takayama S, Masuda H, Tokuyama R, Nakazaki Y, Saito T, Saido T, Murayama S, Ikura T, Ito N, Yamamori Y, Tomii K, Bianchi ME, Okazawa H: HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology. Commun Biol. 2021.10; 4 (1): 1175. ( PubMed , DOI )

  4. Jin M, Jin X, Homma H, Fujita K, Tanaka H, Murayama S, Akatsu H, Tagawa K, Okazawa H: Prediction and verification of the AD-FTLD common pathomechanism based on dynamic molecular network analysis. Commun Biol. 2021.08; 4 (1): 961. ( PubMed , DOI )

  5. Kondo K, Ikura T, Tanaka H, Fujita K, Takayama S, Yoshioka Y, Tagawa K, Homma H, Liu S, Kawasaki R, Huang Y, Ito N, Tate SI, Okazawa H: Hepta-Histidine Inhibits Tau Aggregation. ACS Chem Neurosci. 2021.08; 12 (16): 3015-3027. ( PubMed , DOI )

  6. Homma H, Tanaka H, Jin M, Jin X, Huang Y, Yoshioka Y, Bertens CJ, Tsumaki K, Kondo K, Shiwaku H, Tagawa K, Akatsu H, Atsuta N, Katsuno M, Furukawa K, Ishiki A, Waragai M, Ohtomo G, Iwata A, Yokota T, Inoue H, Arai H, Sobue G, Sone M, Fujita K, Okazawa H: DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis. Life Sci Alliance. 2021.06; 4 (7): e202101022. ( PubMed , DOI )

  1. Tanaka Hikari, Kondo Kanoh, Chen Xigui, Homma Hidenori, Tagawa Kazuhiko, Saido Takaomi, Muramatsu Shin-ichi, Fujita Kyota, Okazawa Hitoshi: 超早期アルツハイマー病においてSRRM2リン酸化はシナプス病理を誘発する(Phosphorylation of SRRM2 leads to synaptic pathology at ultra-early phase of Alzheimer's disease) 臨床神経学. 2020.11; 60 (Suppl.): S345. ( 医中誌 )

  2. Tanaka H, Homma H, Fujita K, Kondo K, Yamada S, Jin X, Waragai M, Ohtomo G, Iwata A, Tagawa K, Atsuta N, Katsuno M, Tomita N, Furukawa K, Saito Y, Saito T, Ichise A, Shibata S, Arai H, Saido T, Sudol M, Muramatsu SI, Okano H, Mufson EJ, Sobue G, Murayama S, Okazawa H: YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology. Nat Commun . 2020.01; 11 (1): 507. ( PubMed , DOI )

  1. Fujita Kyota, Chen Xigui, Homma Hidenori, Tagawa Kazuhiko, Okazawa Hitoshi: Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology(和訳中) 臨床神経学. 2019.11; 59 (Suppl.): S213. ( 医中誌 )

  1. Fujita Kyota, Mao Ying, Uchida Shigenori, Chen Xigui, Shiwaku Hiroki, Tamura Takuya, Ito Hikaru, Homma Hidenori, Tagawa Kazuhiko, Okazawa Hitoshi: Developmental YAPdeltaC determines adult pathology in a mouse model of spinocerebellar ataxia type 1(和訳中) 臨床神経学. 2018.12; 58 (Suppl.): S200. ( 医中誌 )

  2. Tanaka H, Kondo K, Chen X, Homma H, Tagawa K, Kerever A, Aoki S, Saito T, Saido T, Muramatsu S, Fujita K, Okazawa H: The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology. Mol psychiatry. 2018.10; 23 (10): 2090-2110. ( PubMed , DOI )

  3. Fujita K, Homma H, Kondo K, Ikuno M, Yamakado H, Tagawa K, Murayama S, Takahashi R, Okazawa H: Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology. eNeuro. 2018.07; 5 (4): ( PubMed , DOI )

  4. Kyota Fujita, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Mutsuki Amano, Ayumu Saito, Seiya Imoto, Hiroyasu Akatsu, Yoshio Hashizume, Kozo Kaibuchi, Satoru Miyano, Hitoshi Okazawa: Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology. Nat Commun. 2018.01; 9 (1): 433. ( PubMed , DOI )

  1. Fujita K, Mao Y, Uchida S, Chen X, Shiwaku H, Tamura T, Ito H, Watase K, Homma H, Tagawa K, Sudol M, Okazawa H: Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1. Nat Commun. 2017.11; 8 (1): 1864. ( PubMed , DOI )

  2. Chen X., Mao Y., Xu M., Fujita K., Motoki K., Sasabe T., Homma H., Tagawa K., Tamura T., Okazawa H.: Targeting tead/yap-transcription-dependent necrosis, triad, ameliorates Huntington's disease pathology JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 219. ( DOI )

  3. Fujita K., Motoki K., Tagawa K., Chen X., Hama H., Nakajima K., Homma H., Tamura T., Miyawaki A., Okazawa H.: HMGB1 triggers neurite degeneration via TLR4-MARCKS, and is a potential therapeutic target for alzheimer's disease JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 64-65. ( DOI )

  1. Mao Y, Chen X, Xu M, Fujita K, Motoki K, Sasabe T, Homma H, Murata M, Tagawa K, Tamura T, Kaye J, Finkbeiner S, Blandino G, Sudol M, Okazawa H: Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology. Human molecular genetics. 2016.11; 25 (21): 4749-4770. ( PubMed , DOI )

  2. Taniguchi JB, Kondo K, Fujita K, Chen X, Homma H, Sudo T, Mao Y, Watase K, Tanaka T, Tagawa K, Tamura T, Muramatsu SI, Okazawa H: RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair. Hum Mol Genet. 2016.10; 25 (20): 4432-4447. ( PubMed , DOI )

  3. Imamura T, Fujita K, Tagawa K, Ikura T, Chen X, Homma H, Tamura T, Mao Y, Taniguchi JB, Motoki K, Nakabayashi M, Ito N, Yamada K, Tomii K, Okano H, Kaye J, Finkbeiner S, Okazawa H: Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries. Sci Rep. 2016.09; 6 33861. ( PubMed , DOI )

  4. Tomomi Imamura, Kyota Fujita, Kazuhiko Tagawa, Teikichi Ikura, Xigui Chen, Hidenori Homma, Takuya Tamura, Ying Mao, Juliana Bosso Taniguchi, Kazumi Motoki, Makoto Nakabayashi, Nobutoshi Ito, Kazunori Yamada, Kentaro Tomii, Hideyuki Okano, Julia Kaye, Steven Finkbeiner, Hitoshi Okazawa: Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries. Sci Rep. 2016.09; 6 33861. ( PubMed , DOI )

  5. Fujita K, Motoki K, Tagawa K, Chen X, Hama H, Nakajima K, Homma H, Tamura T, Watanabe H, Katsuno M, Matsumi C, Kajikawa M, Saito T, Saido T, Sobue G, Miyawaki A, Okazawa H: HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease. Scientific reports. 2016.08; 6 31895. ( PubMed , DOI )

  6. Mao Y, Tamura T, Yuki Y, Abe D, Tamada Y, Imoto S, Tanaka H, Homma H, Tagawa K, Miyano S, Okazawa H: The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing. Cell Death Dis. 2016.04; 7 (4): e2207. ( PubMed , DOI )

  1. Chen X, Kondo K, Motoki K, Homma H, Okazawa H: Fasting activates macroautophagy in neurons of Alzheimer's disease mouse model but is insufficient to degrade amyloid-beta. Scientific Reports. 2015.07; 5 12115. ( PubMed , DOI )

  2. Hikaru Ito, Kyota Fujita, Kazuhiko Tagawa, Xigui Chen, Hidenori Homma, Toshikazu Sasabe, Jun Shimizu, Shigeomi Shimizu, Takuya Tamura, Shin-ichi Muramatsu, Hitoshi Okazawa: HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice. EMBO Mol Med. 2015.01; 7 (1): 78-101. ( PubMed , DOI )

  1. Tagawa, K., Homma, H., Saito, A., Fujita, K., Chen, X., Imoto, S., Oka, T., Ito, H., Motoki, K., Yoshida, C., Hatsuta, H., Murayama, S., Iwatsubo, T., Miyano, S., Okazawa, H.: Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain. Hum Mol Genet. 2014.09; ( PubMed , DOI )

  2. Ito, H., Shiwaku, H., Yoshida, C., Homma, H., Luo, H., Chen, X., Fujita, K., Musante, L., Fischer, U., Frints, S G M., Romano, C., Ikeuchi, Y., Shimamura, T., Imoto, S., Miyano, S., Muramatsu, S-I., Kawauchi, T., Hoshino, M., Sudol, M., Arumughan, A., Wanker, E E., Rich, T., Schwartz, C., Matsuzaki, F., Bonni, A., Kalscheuer, V M., Okazawa, H.: In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells. Mol Psychiatry. 2014.07; 20 (4): 459-71. ( PubMed , DOI )

  1. 田中 ひかり, 近藤 和, 陳 西貴, 本間 秀典, 田川 一彦, 藤田 慶大, 岡澤 均: 発達障害原因遺伝子PQBP1はアルツハイマー病態を制御する Dementia Japan. 2020.10; 34 (4): 527. ( 医中誌 )

  2. 田中 ひかり, 本間 秀典, 藤田 慶大, 近藤 和, Jin Xiaocen, 田川 一彦, 岡澤 均: YAP依存的ネクローシスは超早期アルツハイマー病態を制御する Dementia Japan. 2020.10; 34 (4): 473. ( 医中誌 )

  3. 田中 ひかり, 岡澤 均: 【神経変性疾患の治療開発の現状-新たな戦略構築の基盤をめざして】各分野の動向　ダウンストリームを治療する　神経細胞死 医学のあゆみ. 2020.04; 273 (1): 93-97. ( 医中誌 )

  4. 田中 ひかり, 岡澤 均: 【よくわかる遺伝子治療-実用化の現状と展望】遺伝子治療各論　脊髄小脳失調症 Clinical Neuroscience. 2020.03; 38 (3): 365-368. ( 医中誌 )

  1. 田中 ひかり, 近藤 和, 陳 西貴, 田川 一彦, Kerever Aurelian, 青木 茂樹, 斉藤 貴志, 西道 隆臣, 村松 慎一, 藤田 慶大, 岡澤 均: 発達障害原因遺伝子PQBP1はアルツハイマー病態を制御する 臨床神経学. 2019.11; 59 (Suppl.): S461. ( 医中誌 )

  1. 藤田 慶大, 陳 西貴, 本間 秀典, 田川 一彦, 岡澤 均: アルツハイマー病と前頭側頭葉変性症に共通する異常タウリン酸化とシナプス障害 Dementia Japan. 2018.09; 32 (3): 431. ( 医中誌 )

  2. 本間 秀典, 岡澤 均: 【ニューロジェネティクス新時代 次世代シークエンサーが拓く新しい世界】筋疾患・神経疾患のジェネティクス ハンチントン病 Clinical Neuroscience. 2018.02; 36 (2): 213-215. ( 医中誌 )

  3. 本間 秀典, 岡澤 均: 【ニューロジェネティクス新時代　次世代シークエンサーが拓く新しい世界】 筋疾患・神経疾患のジェネティクス　ハンチントン病 Clinical Neuroscience. 2018.02; 36 (2): 213-215. ( 医中誌 )

  1. 藤田 慶大, 本木 和美, 田川 一彦, 陳 西貴, 本間 秀典, 岡澤 均: アルツハイマー病において神経突起変性を誘発するHMGB1-MARCKSリン酸化シグナル Dementia Japan. 2017.10; 31 (4): 562. ( 医中誌 )

このページの先頭へ▲