分子細胞生物学分野

102  件  
※ 登録方法の違いにより重複して表示されている場合があります。

  1. Nishita M, Kamizaki K, Hoshi K, Aruga K, Nishikaku I, Shibuya H, Matsumoto K, Minami Y: Rho family small GTPase Rif regulates Wnt5a-Ror1-Dvl2 signaling and promotes lung adenocarcinoma progression. The Journal of biological chemistry. 2023.09; 299 (10): 105248. ( PubMed , DOI )

  2. Goto Toshiyasu, Michiue Tatsuo, Shibuya Hiroshi: ccl19 and ccl21 affect cell movements and differentiation in early Xenopus development DEVELOPMENT GROWTH & DIFFERENTIATION. 2023.04; 65 (3): 175-189. ( PubMed , DOI )

  1. Goto Toshiyasu, Shibuya Hiroshi: maea affects head formation through beta-catenin degradation during early Xenopus laevis development DEVELOPMENT GROWTH & DIFFERENTIATION. 2022.12; ( PubMed , DOI )

  2. Masahiro Shimizu, Hiroshi Shibuya: WNK1/HSN2 mediates neurite outgrowth and differentiation via a OSR1/GSK3β-LHX8 pathway. Sci Rep. 2022.09; 12 (1): ( PubMed , DOI )

  3. Goto T, Michiue T, Shibuya H: ccr7 affects both morphogenesis and differentiation during early Xenopus embryogenesis. Development, growth & differentiation. 2022.05; 64 (5): 254-260. ( PubMed , DOI )

  4. Shimizu M, Shibuya H, Tanaka N: Enhanced O-GlcNAc modification induced by the RAS/MAPK/CDK1 pathway is required for SOX2 protein expression and generation of cancer stem cells. Scientific reports. 2022.02; 12 (1): 2910. ( PubMed , DOI )

  1. Goto T, Keller R: Preparation of three-notochord explants for imaging analysis of the cell movements of convergent extension during early Xenopus morphogenesis. Development, growth & differentiation. 2021.10; ( PubMed , DOI )

  1. Sato Atsushi, Shimizu Masahiro, Goto Toshiyasu, Masuno Hiroyuki, Kagechika Hiroyuki, Tanaka Nobuyuki, Shibuya Hiroshi: WNK regulates Wnt signalling and beta-Catenin levels by interfering with the interaction between beta-Catenin and GID COMMUNICATIONS BIOLOGY. 2020.11; 3 (1): ( DOI )

  1. Shimizu M, Tanaka N: IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells. Oncogene. 2019.02; 38 (9): 1520-1533. ( PubMed , DOI )

  1. Nishita M., Nishikaku I., Yoshida E., Kamizaki K., Shibuya H., Matsumoto K., Minami Y.: Roil promotes invasion of lung adenocarcinoma cells through small GTPase Rif-mediated filopodia formation MOLECULAR BIOLOGY OF THE CELL. 2018.12; 29 (26): 231.

  2. Espiritu EB, Crunk AE, Bais A, Hochbaum D, Cervino AS, Phua YL, Butterworth MB, Goto T, Ho J, Hukriede NA, Cirio MC: The Lhx1-Ldb1 complex interacts with Furry to regulate microRNA expression during pronephric kidney development. Scientific reports. 2018.10; 8 (1): 16029. ( PubMed , DOI )

  3. Goto T, Ito Y, Michiue T.: Roles of Xenopus chemokine ligand CXCLh (XCXCLh) in early embryogenesis. Dev Growth Differ. . 2018.04; 60 226-238.

  4. Sato A, Shibuya H.: Glycogen synthase kinase 3ß functions as a positive effector in the WNK signaling pathway. PLoS One. 2018.03; 13 e0193204.

  1. Michiue T, Yamamoto T, Yasuoka Y, Goto T, Ikeda T, Nagura K, Nakayama T, Taira M, Kinoshita T.: High variability of expression profiles of homeologous genes for Wnt, Hh, Notch, and Hippo signaling pathways in Xenopus laevis. Dev Biol.. 2017.06; 426 (2): 270-290. ( PubMed , DOI )

  1. Toshiyasu Goto, Junhei Matsuzawa, Shun-Ichiro Iemura, Tohru Natsume, Hiroshi Shibuya: WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway. FEBS Lett.. 2016.05; 590 (9): 1291-1303. ( PubMed , DOI )

  2. Takashi Fukuzono, Strahil Iv Pastuhov, Okinobu Fukushima, Chun Li, Ayuna Hattori, Shun-Ichiro Iemura, Tohru Natsume, Hiroshi Shibuya, Hiroshi Hanafusa, Kunihiro Matsumoto, Naoki Hisamoto: Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi. Genes Cells. 2016.04; 21 (4): 311-324. ( PubMed , DOI )

  3. Isao Kii, Yuto Sumida, Toshiyasu Goto, Rie Sonamoto, Yukiko Okuno, Suguru Yoshida, Tomoe Kato-Sumida, Yuka Koike, Minako Abe, Yosuke Nonaka, Teikichi Ikura, Nobutoshi Ito, Hiroshi Shibuya, Takamitsu Hosoya, Masatoshi Hagiwara: Selective inhibition of the kinase DYRK1A by targeting its folding process. Nat Commun. 2016; 7 11391. ( PubMed , DOI )

  1. Nobuyuki Shimizu, Shizuka Ishitani, Atsushi Sato, Hiroshi Shibuya, Tohru Ishitani: Hipk2 and PP1c cooperate to maintain Dvl protein levels required for Wnt signal transduction. Cell Rep. 2014.09; 8 (5): 1391-1404. ( PubMed , DOI )

  1. Toshiyasu Goto, Atsushi Sato, Shungo Adachi, Shun-ichiro Iemura, Tohru Natsume, Hiroshi Shibuya: IQGAP1 protein regulates nuclear localization of β-catenin via importin-β5 protein in Wnt signaling. J. Biol. Chem.. 2013.12; 288 (51): 36351-36360. ( PubMed , DOI )

  2. Masahiro Shimizu, Toshiyasu Goto, Atsushi Sato, Hiroshi Shibuya: WNK4 is an essential effector of anterior formation in FGF signaling. Genes Cells. 2013.06; 18 (6): 442-449. ( PubMed , DOI )

  3. Goto T., Michiue T., Ito Y., Asashima M.: Characterization of CXC-type chemokine molecules in early Xenopus laevis development. Int. J. Dev. Biol.. 2013.03; 57 41-47. ( PubMed , DOI )

  4. Atsushi Sato, Hiroshi Shibuya: WNK signaling is involved in neural development via Lhx8/Awh expression. PLoS ONE. 2013; 8 (1): e55301. ( PubMed , DOI )

  5. Toshiyasu Goto, Atsushi Sato, Masahiro Shimizu, Shungo Adachi, Kiyotoshi Satoh, Shun-ichiro Iemura, Tohru Natsume, Hiroshi Shibuya: IQGAP1 functions as a modulator of dishevelled nuclear localization in Wnt signaling. PLoS ONE. 2013; 8 (4): e60865. ( PubMed , DOI )

  1. Goto T., Asashima M.: Chemokine ligand Xenopus CXCLC (XCXCLC) regulates cell movements during early morphogenesis. Dev. Growth Differ.. 2011.12; 53 971-981.. ( PubMed , DOI )

  2. Hiroshi Hanafusa, Kouki Ishikawa, Shin Kedashiro, Tsukasa Saigo, Shun-Ichiro Iemura, Tohru Natsume, Masayuki Komada, Hiroshi Shibuya, Atsuki Nara, Kunihiro Matsumoto: Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor. Nat Commun. 2011.01; 2 158. ( PubMed , DOI )

  1. Toshiyasu Goto, Akimasa Fukui, Hiroshi Shibuya, Ray Keller, Makoto Asashima: Xenopus furry contributes to release of microRNA gene silencing. Proc. Natl. Acad. Sci. U.S.A.. 2010.11; 107 (45): 19344-19349. ( PubMed , DOI )

  2. Ogawa Y., Nonaka Y., Goto T., Ohnishi E., Hiramatsu T., Kii I., Yoshida M., Ikura T., Onogi H., Shibuya H., Hosoya T., Ito N., Hagiwara M.: Development of a novel selective inhibitor of the Downsyndrome-related kinase Dyrk1A. Nat. Commun.. 2010.10; ( PubMed , DOI )

  3. Takeshi Maruyama, Hisae Kadowaki, Noriaki Okamoto, Atsushi Nagai, Isao Naguro, Atsushi Matsuzawa, Hiroshi Shibuya, Keiji Tanaka, Shigeo Murata, Kohsuke Takeda, Hideki Nishitoh, Hidenori Ichijo: CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response. EMBO J.. 2010.08; 29 (15): 2501-2514. ( PubMed , DOI )

  4. Akira Nifuji, Hisashi Ideno, Yoshio Ohyama, Rieko Takanabe, Ryoko Araki, Masumi Abe, Masaki Noda, Hiroshi Shibuya: Nemo-like kinase (NLK) expression in osteoblastic cells and suppression of osteoblastic differentiation. Exp. Cell Res.. 2010.04; 316 (7): 1127-1136. ( PubMed , DOI )

  5. Goto T., Ohnishi E., Sato A.(The first three authors contributed equally), Kim M., Iemura S., Ishitani T., Natsume T., Ohnishi J.and Shibuya H.: Nemo-like kinase, an essential effector of anterior formation, functions downstream of p38 MAP kinase. Mol. Cell. Biol.. 2010.02; 30 675-683. ( PubMed , DOI )

  6. Eriko Ohnishi, Toshiyasu Goto, Atsushi Sato, Mi-Sun Kim, Shun-Ichiro Iemura, Tohru Ishitani, Tohru Natsume, Junji Ohnishi, Hiroshi Shibuya: Nemo-like kinase, an essential effector of anterior formation, functions downstream of p38 mitogen-activated protein kinase. Mol. Cell. Biol.. 2010.02; 30 (3): 675-683. ( PubMed , DOI )

  7. Yukihide Watanabe, Susumu Itoh, Toshiyasu Goto, Eriko Ohnishi, Masako Inamitsu, Fumiko Itoh, Kiyotoshi Satoh, Eliza Wiercinska, Weiwen Yang, Liang Shi, Aya Tanaka, Naoko Nakano, A Mieke Mommaas, Hiroshi Shibuya, Peter Ten Dijke, Mitsuyasu Kato: TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling. Mol. Cell. 2010.01; 37 (1): 123-134. ( PubMed , DOI )

  1. Goto T., Keller R. and Asashima M.: Concentrations of TBP-type genes affect chordamesodermal gene expression. Int. J. Dev. Biol.. 2008.03; 52 371-375. ( PubMed , DOI )

  2. Kawasaki A., Kumasaka M., Satoh A., Suzuki M., Tamura K., Goto T., Asashima M., Yamamoto H.: Mitf contributes to melanosome distribution and melanophore dendricity. Pigment Cell Melanoma Res.. 2008.02; 21 56-62. ( PubMed , DOI )

  3. Hisamoto N, Moriguchi T, Urushiyama S, Mitani S, Shibuya H, Matsumoto K: Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity. EMBO Rep. 2008.01; 9 (1): 70-75. ( PubMed , DOI )

  1. Satoh K, Ohnishi J, Sato A, Takeyama M, Iemura S, Natsume T, Shibuya H: Nemo-like kinase-myocyte enhancer factor 2A signaling regulates anterior formation in Xenopus development. Mol Cell Biol. 2007.11; 27 (21): 7623-7630. ( PubMed , DOI )

  2. Yang Sung-Sen, Morimoto Tetsuji, Rai Tatemitsu, Chiga Motoko, Sohara Eisei, Ohno Mayuko, Uchida Keiko, Lin Shih-Hua, Moriguchi Tetsuo, Shibuya Hiroshi, Kondo Yoshiaki, Sasaki Sei, Uchida Shinichi: Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab. 2007.05; 5 (5): 331-344. ( PubMed , DOI )

  3. Suzawa K., Yukita A., Hayata T., Goto T., Danno H., Michiue T., Cho K.W., Asashima M.: Xenopus glucose transporter 1 (xGLUT1) is required for gastrulation movement in Xenopus laevis. Int. J. Dev. Biol.. 2007.03; 51 183-190. ( PubMed , DOI )

  4. Goto T., Fukui A. (The first two authors contributed equally), Kitamoto J., Homma M., Asashima M.: SDF-1 alpha regulates mesendodermal cell migration during frog gastrulation. Biochem. Biophys. Res. Commun.. 2007.03; 354 422-427. ( PubMed , DOI )

  5. Matsubara Y, Kawasaki I, Urushiyama S, Yasuda T, Shirakata M, Iino Y, Shibuya H, Yamanashi Y: The adaptor-like protein ROG-1 is required for activation of the Ras-MAP kinase pathway and meiotic cell cycle progression in Caenorhabditis elegans. Genes Cells. 2007.03; 12 (3): 407-420. ( PubMed , DOI )

  1. Yamada M, Ohnishi J, Ohkawara B, Iemura S, Satoh K, Hyodo-Miura J, Kawachi K, Natsume T, Shibuya H: NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF). J Biol Chem. 2006.07; 281 (30): 20749-20760. ( PubMed , DOI )

  2. Honma M, Higuchi O, Shirakata M, Yasuda T, Shibuya H, Iemura S, Natsume T, Yamanashi Y: Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases. Genes Cells. 2006.02; 11 (2): 143-151. ( PubMed , DOI )

  1. Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H: WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J Biol Chem. 2005.12; 280 (52): 42685-42693. ( PubMed , DOI )

  2. Ohnishi J, Ohnishi E, Shibuya H, Takahashi T: Functions for proteinases in the ovulatory process. Biochim Biophys Acta. 2005.08; 1751 (1): 95-109. ( PubMed , DOI )

  3. Goto T., Davidson L., Asashima M., Keller R.: Planar cell polarity genes regulate polarized extracellular matrix deposition during frog gastrulation. Curr. Biol.. 2005.04; 15 787-793. ( PubMed , DOI )

  1. Adachi S, Jigami T, Yasui T, Nakano T, Ohwada S, Omori Y, Sugano S, Ohkawara B, Shibuya H, Nakamura T, Akiyama T: Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling. Cancer Res. 2004.12; 64 (23): 8496-8501. ( PubMed , DOI )

  2. Aoyama Y, Urushiyama S, Yamada M, Kato C, Ide H, Higuchi S, Akiyama T, Shibuya H: MFB-1, an F-box-type ubiquitin ligase, regulates TGF-beta signalling. Genes Cells. 2004.11; 9 (11): 1093-1101. ( PubMed , DOI )

  3. Muraki M, Ohkawara B, Hosoya T, Onogi H, Koizumi J, Koizumi T, Sumi K, Yomoda J, Murray MV, Kimura H, Furuichi K, Shibuya H, Krainer AR, Suzuki M, Hagiwara M: Manipulation of alternative splicing by a newly developed inhibitor of Clks. J Biol Chem. 2004.06; 279 (23): 24246-24254. ( PubMed , DOI )

  4. Ohkawara B, Shirakabe K, Hyodo-Miura J, Matsuo R, Ueno N, Matsumoto K, Shibuya H: Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction. Genes Dev. 2004.02; 18 (4): 381-386. ( PubMed , DOI )

  1. Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K: Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. EMBO J. 2003.12; 22 (23): 6277-6288. ( PubMed , DOI )

  2. Yamada M, Ohkawara B, Ichimura N, Hyodo-Miura J, Urushiyama S, Shirakabe K, Shibuya H: Negative regulation of Wnt signalling by HMG2L1, a novel NLK-binding protein. Genes Cells. 2003.08; 8 (8): 677-684. ( PubMed )

  3. Oishi I, Suzuki H, Onishi N, Takada R, Kani S, Ohkawara B, Koshida I, Suzuki K, Yamada G, Schwabe GC, Mundlos S, Shibuya H, Takada S, Minami Y: The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells. 2003.07; 8 (7): 645-654. ( PubMed )

  4. Suzawa M, Takada I, Yanagisawa J, Ohtake F, Ogawa S, Yamauchi T, Kadowaki T, Takeuchi Y, Shibuya H, Gotoh Y, Matsumoto K, Kato S: Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade. Nat Cell Biol. 2003.03; 5 (3): 224-230. ( PubMed , DOI )

  5. Ishitani T, Kishida S, Hyodo-Miura J, Ueno N, Yasuda J, Waterman M, Shibuya H, Moon RT, Ninomiya-Tsuji J, Matsumoto K: The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol. 2003.01; 23 (1): 131-139. ( PubMed )

  1. Komatsu Y, Shibuya H, Takeda N, Ninomiya-Tsuji J, Yasui T, Miyado K, Sekimoto T, Ueno N, Matsumoto K, Yamada G: Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis. Mech Dev. 2002.12; 119 (2): 239-249. ( PubMed )

  2. Goto T., Wallingford J.B.(The first two authors contributed equally), Keller R., Harland R.M.: Cloning and expression of Xenopus Prickle, an orthologue of a Drosophila planar cell polarity gene. Mech. Dev.. 2002.08; 116 183-186. ( PubMed )

  3. Goto T. (corresponding author), Keller R.: The planar cell polarity gene strabismus regulates convergence and extension and neural fold closure in Xenopus. Dev. Biol.. 2002.07; 247 165-181. ( PubMed , DOI )

  4. Hyodo-Miura J, Urushiyama S, Nagai S, Nishita M, Ueno N, Shibuya H: Involvement of NLK and Sox11 in neural induction in Xenopus development. Genes Cells. 2002.05; 7 (5): 487-496. ( PubMed )

  1. Yanagisawa M, Nakashima K, Takeda K, Ochiai W, Takizawa T, Ueno M, Takizawa M, Shibuya H, Taga T: Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7. Genes Cells. 2001.12; 6 (12): 1091-1099. ( PubMed )

  2. Shirakabe K, Terasawa K, Miyama K, Shibuya H, Nishida E: Regulation of the activity of the transcription factor Runx2 by two homeobox proteins, Msx2 and Dlx5. Genes Cells. 2001.10; 6 (10): 851-856. ( PubMed )

  3. Sugawara K, Morita K, Ueno N, Shibuya H: BIP, a BRAM-interacting protein involved in TGF-beta signalling, regulates body length in Caenorhabditis elegans. Genes Cells. 2001.07; 6 (7): 599-606. ( PubMed )

  4. Ohnishi J, Ohnishi E, Jin M, Hirano W, Nakane D, Matsui H, Kimura A, Sawa H, Nakayama K, Shibuya H, Nagashima K, Takahashi T: Cloning and characterization of a rat ortholog of MMP-23 (matrix metalloproteinase-23), a unique type of membrane-anchored matrix metalloproteinase and conditioned switching of its expression during the ovarian follicular development. Mol Endocrinol. 2001.05; 15 (5): 747-764. ( PubMed )

  5. Morita K, Shimizu M, Shibuya H, Ueno N: A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta signaling. Proc Natl Acad Sci U S A. 2001.05; 98 (11): 6284-6288. ( PubMed , DOI )

  6. Goto T., Hasegawa K., Kinoshita T., Kubota H.Y.: A novel POZ/zinc finger protein, champignon, interferes with gastrulation movements in Xenopus. Dev. Dyn.. 2001.05; 221 14-25. ( PubMed , DOI )

  7. Noakes C.R., Goto T., Keller R., Periasamy A.: Does digital deconvolution improve two-photon microscopy in deep tissue imaging? Proc. SPIE. 2001.04; 4262 389-395. ( DOI )

  8. Masuda Y, Sasaki A, Shibuya H, Ueno N, Ikeda K, Watanabe K: Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function. J Biol Chem. 2001.02; 276 (7): 5331-5338. ( PubMed , DOI )

  1. Hanafusa H, Masuyama N, Kusakabe M, Shibuya H, Nishida E: The TGF-beta family member derriere is involved in regulation of the establishment of left-right asymmetry. EMBO Rep. 2000.07; 1 (1): 32-39. ( PubMed , DOI )

  2. Tago K, Nakamura T, Nishita M, Hyodo J, Nagai S, Murata Y, Adachi S, Ohwada S, Morishita Y, Shibuya H, Akiyama T: Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. Genes Dev. 2000.07; 14 (14): 1741-1749. ( PubMed )

  3. Goto T. (corresponding author), Katada T., Kinoshita T., Kubota H.Y.: Expression and characterization of Xenopus type I collagen alpha 1 (COL1A1) during embryonic development. Dev. Growth Differ.. 2000.06; 42 249-256. ( PubMed )

  4. Kimura N, Matsuo R, Shibuya H, Nakashima K, Taga T: BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. J Biol Chem. 2000.06; 275 (23): 17647-17652. ( PubMed , DOI )

  5. Takatsu Y, Nakamura M, Stapleton M, Danos MC, Matsumoto K, O'Connor MB, Shibuya H, Ueno N: TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development. Mol Cell Biol. 2000.05; 20 (9): 3015-3026. ( PubMed )

  6. Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K: TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol Cell. 2000.04; 5 (4): 649-658. ( PubMed )

  7. 後藤利保: アフリカツメガエルの原腸陥入運動の分子機構に関する研究 2000.03; ( DOI )

  8. Nishita M, Hashimoto MK, Ogata S, Laurent MN, Ueno N, Shibuya H, Cho KW: Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer. Nature. 2000.02; 403 (6771): 781-785. ( PubMed , DOI )

  1. Nishita M, Ueno N, Shibuya H: Smad8B, a Smad8 splice variant lacking the SSXS site that inhibits Smad8-mediated signalling. Genes Cells. 1999.10; 4 (10): 583-591. ( PubMed )

  2. Hanafusa H, Ninomiya-Tsuji J, Masuyama N, Nishita M, Fujisawa J, Shibuya H, Matsumoto K, Nishida E: Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression. J Biol Chem. 1999.09; 274 (38): 27161-27167. ( PubMed )

  3. Ishitani T, Ninomiya-Tsuji J, Nagai S, Nishita M, Meneghini M, Barker N, Waterman M, Bowerman B, Clevers H, Shibuya H, Matsumoto K: The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF. Nature. 1999.06; 399 (6738): 798-802. ( PubMed , DOI )

  4. Miyama K, Yamada G, Yamamoto TS, Takagi C, Miyado K, Sakai M, Ueno N, Shibuya H: A BMP-inducible gene, dlx5, regulates osteoblast differentiation and mesoderm induction. Dev Biol. 1999.04; 208 (1): 123-133. ( PubMed , DOI )

  5. Masuyama N, Hanafusa H, Kusakabe M, Shibuya H, Nishida E: Identification of two Smad4 proteins in Xenopus. Their common and distinct properties. J Biol Chem. 1999.04; 274 (17): 12163-12170. ( PubMed )

  6. Goto T., Kinoshita T.: Maternal transcripts of mitotic checkpoint gene, Xbub3, are accumulated in the animal blastomeres of Xenopus early embryo. DNA Cell Biol.. 1999.03; 18 227-234. ( PubMed , DOI )

  7. Hamada F, Tomoyasu Y, Takatsu Y, Nakamura M, Nagai S, Suzuki A, Fujita F, Shibuya H, Toyoshima K, Ueno N, Akiyama T: Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin. Science. 1999.03; 283 (5408): 1739-1742. ( PubMed )

  8. Yamaguchi K, Nagai S, Ninomiya-Tsuji J, Nishita M, Tamai K, Irie K, Ueno N, Nishida E, Shibuya H, Matsumoto K: XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway. EMBO J. 1999.01; 18 (1): 179-187. ( PubMed , DOI )

  1. Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H: BRAM1, a BMP receptor-associated molecule involved in BMP signalling. Genes Cells. 1998.04; 3 (4): 257-264. ( PubMed )

  2. Shibuya H, Iwata H, Masuyama N, Gotoh Y, Yamaguchi K, Irie K, Matsumoto K, Nishida E, Ueno N: Role of TAK1 and TAB1 in BMP signaling in early Xenopus development. EMBO J. 1998.02; 17 (4): 1019-1028. ( PubMed , DOI )

  1. Gotou T., Kinoshita K., Kinoshita T.: Calcium ionophore affecting the invagination in early Xenopus development. Kwansei Gakuin University Natural Sciences Reviews. 1997.10; 2 35-48.

  2. Akiyama S, Katagiri T, Namiki M, Yamaji N, Yamamoto N, Miyama K, Shibuya H, Ueno N, Wozney JM, Suda T: Constitutively active BMP type I receptors transduce BMP-2 signals without the ligand in C2C12 myoblasts. Exp Cell Res. 1997.09; 235 (2): 362-369. ( PubMed , DOI )

  3. Shirakabe K, Yamaguchi K, Shibuya H, Irie K, Matsuda S, Moriguchi T, Gotoh Y, Matsumoto K, Nishida E: TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase. J Biol Chem. 1997.03; 272 (13): 8141-8144. ( PubMed )

  1. Moriguchi T, Kuroyanagi N, Yamaguchi K, Gotoh Y, Irie K, Kano T, Shirakabe K, Muro Y, Shibuya H, Matsumoto K, Nishida E, Hagiwara M: A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J Biol Chem. 1996.06; 271 (23): 13675-13679. ( PubMed )

  2. Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, Irie K, Nishida E, Matsumoto K: TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science. 1996.05; 272 (5265): 1179-1182. ( PubMed )

  1. Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, Taniguchi T, Nishida E, Matsumoto K: Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science. 1995.12; 270 (5244): 2008-2011. ( PubMed )

  1. Shibuya H, Kohu K, Yamada K, Barsoumian EL, Perlmutter RM, Taniguchi T: Functional dissection of p56lck, a protein tyrosine kinase which mediates interleukin-2-induced activation of the c-fos gene. Mol Cell Biol. 1994.09; 14 (9): 5812-5819. ( PubMed )

  1. Shibuya H, Yoneyama M, Ninomiya-Tsuji J, Matsumoto K, Taniguchi T: IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-myc. Cell. 1992.07; 70 (1): 57-67. ( PubMed )

  2. Shibuya H, Irie K, Ninomiya-Tsuji J, Goebl M, Taniguchi T, Matsumoto K: New human gene encoding a positive modulator of HIV Tat-mediated transactivation. Nature. 1992.06; 357 (6380): 700-702. ( PubMed , DOI )

  3. Hatakeyama M, Kawahara A, Mori H, Shibuya H, Taniguchi T: c-fos gene induction by interleukin 2: identification of the critical cytoplasmic regions within the interleukin 2 receptor beta chain. Proc Natl Acad Sci U S A. 1992.03; 89 (6): 2022-2026. ( PubMed )

  1. Shibuya H, Yoneyama M, Nakamura Y, Harada H, Hatakeyama M, Minamoto S, Kono T, Doi T, White R, Taniguchi T: The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignment. Nucleic Acids Res. 1990.07; 18 (13): 3697-3703. ( PubMed )

  1. Shibuya H, Taniguchi T: Identification of multiple cis-elements and trans-acting factors involved in the induced expression of human IL-2 gene. Nucleic Acids Res. 1989.11; 17 (22): 9173-9184. ( PubMed )

  2. Shibuya H, Yoneyama M, Taniguchi T: Involvement of a common transcription factor in the regulated expression of IL-2 and IL-2 receptor genes. Int Immunol. 1989; 1 (1): 43-49. ( PubMed )

  1. Fujita T, Shibuya H, Hotta H, Yamanishi K, Taniguchi T: Interferon-beta gene regulation: tandemly repeated sequences of a synthetic 6 bp oligomer function as a virus-inducible enhancer. Cell. 1987.05; 49 (3): 357-367. ( PubMed )

  2. Maruyama M, Shibuya H, Harada H, Hatakeyama M, Seiki M, Fujita T, Inoue J, Yoshida M, Taniguchi T: Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering. Cell. 1987.01; 48 (2): 343-350. ( PubMed )

  1. Fujita T, Shibuya H, Ohashi T, Yamanishi K, Taniguchi T: Regulation of human interleukin-2 gene: functional DNA sequences in the 5' flanking region for the gene expression in activated T lymphocytes. Cell. 1986.08; 46 (3): 401-405. ( PubMed )

  1. Sato Atsushi, Shibuya Hiroshi: Glycogen synthase kinase 3 beta functions as a positive effector in the WNK signaling pathway PLOS ONE. 2018.03; 13 (3): e0193204. ( PubMed , DOI )

  1. 清水 幹容, 田中 信之: ケモカインIL-8による糖代謝の制御機構とがん幹細胞への影響 生命科学系学会合同年次大会. 2017.12; 2017年度 [1P-1045]. ( 医中誌 )

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