Division of Visionary Life Science

813  articles.  
* There may be some overlapped articles listed due to the difference of format.

  1. Oikawa, T; Hasegawa, J; Handa, H; Ohnishi, N; Onodera, Y; Hashimoto, A; Sasaki, J; Sasaki, T; Ueda, K; Sabe, H: p53 ensures the normal behavior and modi fi cation of G1/S-speci fi c histone H3.1 in the nucleus LIFE SCIENCE ALLIANCE. 2024.09; 7 (9): ( PubMed , DOI )

  2. Takafumi Kawai, Shin Morioka, Haruhiko Miyata, Rizki Tsari Andriani, Sharmin Akter, Gabriel Toma, Tatsuya Nakagawa, Yuki Oyama, Rie Iida-Norita, Junko Sasaki, Masahiko Watanabe, Kenji Sakimura, Masahito Ikawa, Takehiko Sasaki, Yasushi Okamura: The significance of electrical signals in maturing spermatozoa for phosphoinositide regulation through voltage-sensing phosphatase. Nat Commun. 2024.08; 15 (1): 7289. ( PubMed , DOI )

  3. Satoshi Kofuji, Kara Wolfe, Kazutaka Sumita, Shun Kageyama, Hirofumi Yoshino, Yoshihisa Hirota, Aki Ogawa-Iio, Hirotaka Kanoh, Mika Sasaki, Kaori Kofuji, Mindy I Davis, Rajan Pragani, Min Shen, Matthew B Boxer, Fubito Nakatsu, Kiyomi Nigorikawa, Takehiko Sasaki, Koh Takeuchi, Toshiya Senda, Seong M Kim, Aimee L Edinger, Anton Simeonov, Atsuo T Sasaki: A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion. Biochem Biophys Res Commun. 2024.07; 718 149981. ( PubMed , DOI )

  4. Tarapongpun T, Onlamoon N, Tabu K, Chuthapisith S, Taga T: The optimized priming effect of FGF-1 and FGF-2 enhances preadipocyte lineage commitment in human adipose-derived mesenchymal stem cells. Genes to cells. 2024.03; 29 (3): 231-253. ( PubMed , DOI )

  5. Riki Ishibashi, Ritsuko Maki, Fumiko Toyoshima: Gene targeting in adult organs using in vivo cleavable donor plasmids for CRISPR-Cas9 and CRISPR-Cas12a Scientific Reports. 2024.03; 14 (1): 7615. ( DOI )

  1. Satoshi Kozuki, Mio Kabata, Satoko Sakurai, Keiko Iwaisako, Tomomi Nishimura, Masakazu Toi, Takuya Yamamoto, Fumiko Toyoshima: Periportal hepatocyte proliferation at midgestation governs maternal glucose homeostasis in mice Communications Biology. 2023.12; 6 (1): 1226. ( DOI )

  2. Pu J, Kofuji S, Okamoto-Uchida Y, Danzaki K, Yu R, Suzuki A, Kitajima S, Nishina H: Lethal Phenotype-Based Database Screening Identifies Ceramide as a Negative Regulator of Primitive Streak Formation. Stem cells (Dayton, Ohio). 2023.10; 41 (12): 1142-1156. ( PubMed , DOI )

  3. Arihisa Wataru, Kondo Takeshi, Yamaguchi Katsushi, Matsumoto Junya, Nakanishi Hiroki, Kunii Yasuto, Akatsu Hiroyasu, Hino Mizuki, Hashizume Yoshio, Sato Shumpei, Sato Shinji, Niwa Shin-ichi, Yabe Hirooki, Sasaki Takehiko, Shigenobu Shuji, Setou Mitsutoshi: トランスクリプトームにおける脂質関連変化は日本人統合失調症患者の死後前頭前皮質における数種の特定経路で強化されている(Lipid-correlated alterations in the transcriptome are enriched in several specific pathways in the postmortem prefrontal cortex of Japanese patients with schizophrenia) Neuropsychopharmacology Reports. 2023.09; 43 (3): 403-413. ( ichushi )

  4. Yoshitaka Murota, Mariko Nagane, Mei Wu, Mithun Santra, Seshasailam Venkateswaran, Shinji Tanaka, Mark Bradley, Tetsuya Taga, Kouichi Tabu : A niche-mimicking polymer hydrogel-based approach to identify molecular targets for tackling human pancreatic cancer stem cells Inflammation and Regeneration. 2023.09; 43 (1): 46. ( PubMed , DOI )

  5. Nishita M, Kamizaki K, Hoshi K, Aruga K, Nishikaku I, Shibuya H, Matsumoto K, Minami Y: Rho family small GTPase Rif regulates Wnt5a-Ror1-Dvl2 signaling and promotes lung adenocarcinoma progression. The Journal of biological chemistry. 2023.09; 299 (10): 105248. ( PubMed , DOI )

  6. Murota Y, Nagane M, Wu M, Santra M, Venkateswaran S, Tanaka S, Bradley M, Taga T, Tabu K: A niche-mimicking polymer hydrogel-based approach to identify molecular targets for tackling human pancreatic cancer stem cells. Inflammation and regeneration. 2023.09; 43 (1): 46. ( PubMed , DOI )

  7. Arihisa W, Kondo T, Yamaguchi K, Matsumoto J, Nakanishi H, Kunii Y, Akatsu H, Hino M, Hashizume Y, Sato S, Sato S, Niwa SI, Yabe H, Sasaki T, Shigenobu S, Setou M: Lipid-correlated alterations in the transcriptome are enriched in several specific pathways in the postmortem prefrontal cortex of Japanese patients with schizophrenia. Neuropsychopharmacology reports. 2023.09; 43 (3): 403-413. ( PubMed , DOI )

  8. Melig G, Nobuhisa I, Saito K, Tsukahara R, Itabashi A, Kanai Y, Kanai-Azuma M, Osawa M, Oshima M, Iwama A, Taga T: A Sox17 downstream gene Rasip1 is involved in the hematopoietic activity of intra-aortic hematopoietic clusters in the midgestation mouse embryo. Inflamm Regen. 2023.08; 43 (1): 41. ( PubMed , DOI )

  9. Ikeda Y, Davis MI, Sumita K, Zheng Y, Kofuji S, Sasaki M, Hirota Y, Pragani R, Shen M, Boxer MB, Takeuchi K, Senda T, Simeonov A, Sasaki AT: Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and biophysical research communications. 2023.08; 679 116-121. ( PubMed , DOI )

  10. Tamara A M Chessa, Piotr Jung, Arqum Anwar, Sabine Suire, Karen E Anderson, David Barneda, Anna Kielkowska, Barzan A Sadiq, Ieng Wai Lai, Sergio Felisbino, Daniel J Turnham, Helen B Pearson, Wayne A Phillips, Junko Sasaki, Takehiko Sasaki, David Oxley, Dominik Spensberger, Anne Segonds-Pichon, Michael Wilson, Simon Walker, Hanneke Okkenhaug, Sabina Cosulich, Phillip T Hawkins, Len R Stephens: PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate. Mol Cell. 2023.08; 83 (16): 2991-3009.e13. ( PubMed , DOI )

  11. Hajime Tajima Sakurai, Hidefumi Iwashita, Satoko Arakawa, Alifu Yikelamu, Mizuki Kusaba, Satoshi Kofuji, Hiroshi Nishina, Munetaka Ishiyama, Yuichiro Ueno, Shigeomi Shimizu: Development of small fluorescent probes for the analysis of autophagy kinetics. iScience. 2023.07; 26 (7): 107218. ( PubMed , DOI )

  12. Dang Minh Tran, Nozomu Yoshioka, Norihisa Bizen, Yukiko Mori-Ochiai, Masato Yano, Shogo Yanai, Junya Hasegawa, Satoshi Miyashita, Mikio Hoshino, Junko Sasaki, Takehiko Sasaki, Hirohide Takebayashi: Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity. Dis Model Mech. 2023.07; 16 (7): ( PubMed , DOI )

  13. Noriyuki Azuma, Tadashi Yokoi, Taku Tanaka, Emiko Matsuzaka, Yuki Saida, Sachiko Nishina, Miho Terao, Shuji Takada, Maki Fukami, Kohji Okamura, Kayoko Maehara, Tokiwa Yamasaki, Jun Hirayama, Hiroshi Nishina, Hiroshi Handa, Yuki Yamaguchi: Integrator complex subunit 15 controls mRNA splicing and is critical for eye development. Hum Mol Genet. 2023.06; 32 (12): 2032-2045. ( PubMed , DOI )

  14. Goto Toshiyasu, Michiue Tatsuo, Shibuya Hiroshi: ccl19 and ccl21 affect cell movements and differentiation in early Xenopus development DEVELOPMENT GROWTH & DIFFERENTIATION. 2023.04; 65 (3): 175-189. ( PubMed , DOI )

  15. Yusuke Kiyoki, Takayasu Kato, Sakura Kito, Takashi Matsuzaka, Shin Morioka, Junko Sasaki, Kenichi Makishima, Tatsuhiro Sakamoto, Hidekazu Nishikii, Naoshi Obara, Mamiko Sakata-Yanagimoto, Takehiko Sasaki, Hitoshi Shimano, Shigeru Chiba: The fatty acid elongase Elovl6 is crucial for hematopoietic stem cell engraftment and leukemia propagation. Leukemia. 2023.04;

  16. Akihiro Iguchi, Sho Takatori, Shingo Kimura, Hiroki Muneto, Kai Wang, Hayato Etani, Genta Ito, Haruaki Sato, Yukiko Hori, Junko Sasaki, Takashi Saito, Takaomi C Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomita: INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model. iScience. 2023.04; 26 (4): 106375. ( PubMed , DOI )

  17. Yusuke Kiyoki, Takayasu Kato, Sakura Kito, Takashi Matsuzaka, Shin Morioka, Junko Sasaki, Kenichi Makishima, Tatsuhiro Sakamoto, Hidekazu Nishikii, Naoshi Obara, Mamiko Sakata-Yanagimoto, Takehiko Sasaki, Hitoshi Shimano, Shigeru Chiba: The fatty acid elongase Elovl6 is crucial for hematopoietic stem cell engraftment and leukemia propagation. Leukemia. 2023.03; ( PubMed , DOI )

  18. Kashiwagi Taichi, Takazawa Yuuki, Kagawa Tetsushi, Taga Tetsuya: Organization of self-advantageous niche by neural stem/progenitor cells during development via autocrine VEGF-A under hypoxia Inflammation and Regeneration. 2023.02; 43 (1): 8. ( PubMed , DOI )

  19. Takahito Miyake, Yuichi Inoue, Xinyan Shao, Takehito Seta, Yuto Aoki, Khanh Tien Nguyen Pham, Yuichi Shichino, Junko Sasaki, Takehiko Sasaki, Masahito Ikawa, Yoshiaki Yamaguchi, Hitoshi Okamura, Shintaro Iwasaki, Masao Doi: Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm. Cell Rep. 2023.02; 112157. ( PubMed , DOI )

  20. Jing Pu, Satoshi Kofuji, Yoshimi Okamoto-Uchida, Keiko Danzaki, Ruoxing Yu, Akira Suzuki, Satoshi Kitajima and Hiroshi Nishina: Lethal phenotype-based database screening identifies ceramide as a negative regulator of primitive streak formation Stem Cells. 2023;

  21. Jing Pu, Satoshi Kofuji, Yoshimi Okamoto-Uchida, Keiko Danzaki, Ruoxing Yu, Akira Suzuki, Satoshi Kitajima and Hiroshi Nishina: Lethal phenotype-based database screening identifies ceramide as a negative regulator of primitive streak formation. Stem Cells. 2023;

  22. Jing Pu, Satoshi Kofuji, Yoshimi Okamoto-Uchida, Keiko Danzaki, Ruoxing Yu, Akira Suzuki, Satoshi Kitajima, Hiroshi Nishina: Lethal Phenotype-Based Database Screening Identifies Ceramide as a Negative Regulator of Primitive Streak Formation Stem Cells. 2023;

  1. Oda C, Kamimura K, Shibata O, Morita S, Tanaka Y, Setsu T, Abe H, Yokoo T, Sakamaki A, Kamimura H, Kofuji S, Wakai T, Nishina H, Terai S: HBx and YAP expression could promote tumor development and progression in HBV-related hepatocellular carcinoma. Biochemistry and biophysics reports. 2022.12; 32 101352. ( PubMed , DOI )

  2. Miyata Y, Segawa K: Protocol to analyze lipid asymmetry in the plasma membrane. STAR protocols. 2022.12; 3 (4): 101870. ( PubMed , DOI )

  3. Goto Toshiyasu, Shibuya Hiroshi: maea affects head formation through beta-catenin degradation during early Xenopus laevis development DEVELOPMENT GROWTH & DIFFERENTIATION. 2022.12; ( PubMed , DOI )

  4. Wenqian Wang, Kouichi Tabu, Alapati Aimaitijiang, Tetsuya Taga: Therapy-resistant nature of cancer stem cells in view of iron metabolism Inflammation and Regeneration. 2022.11; 42 (1): 34.

  5. Tabu Kouichi, Taga Tetsuya: Cancer ego-system in glioma: an iron-replenishing niche network systemically self-organized by cancer stem cells Inflammation and Regeneration. 2022.11; 42 (1): 54. ( PubMed , DOI )

  6. Kobayashi Sakurako, Ogasawara Nobuhiko, Watanabe Satoshi, Yoneyama Yosuke, Kirino Sakura, Hiraguri Yui, Inoue Masami, Nagata Sayaka, Okamoto-Uchida Yoshimi, Kofuji Satoshi, Shimizu Hiromichi, Ito Go, Mizutani Tomohiro, Yamauchi Shinichi, Kinugasa Yusuke, Kano Yoshihito, Nemoto Yasuhiro, Watanabe Mamoru, Tsuchiya Kiichiro, Nishina Hiroshi, Okamoto Ryuichi, Yui Shiro: Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation(タイトル和訳中) Inflammation and Regeneration. 2022.11; 42 1 of 18-18 of 18. ( ichushi )

  7. Sakurako Kobayashi, Nobuhiko Ogasawara, Satoshi Watanabe, Yosuke Yoneyama, Sakura Kirino, Yui Hiraguri, Masami Inoue, Sayaka Nagata, Yoshimi Okamoto-Uchida, Satoshi Kofuji, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Shinichi Yamauchi, Yusuke Kinugasa, Yoshihito Kano, Yasuhiro Nemoto, Mamoru Watanabe, Kiichiro Tsuchiya, Hiroshi Nishina, Ryuichi Okamoto, Shiro Yui: Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation. Inflamm Regen. 2022.11; 42 (1): 49. ( PubMed , DOI )

  8. Ishibashi R, Maki R, Kitano S, Miyachi H, Toyoshima F.: Development of an in vivo cleavable donor plasmid for targeted transgene integration by CRISPR-Cas9 and CRISPR-Cas12a Scientific Reports. 2022.10; 12 (1): ( DOI )

  9. Tomonori Ayukawa, Masakazu Akiyama, Yasukazu Hozumi, Kenta Ishimoto, Junko Sasaki, Haruki Senoo, Takehiko Sasaki, Masakazu Yamazaki: Tissue flow regulates planar cell polarity independently of the Frizzled core pathway. Cell Rep. 2022.09; 40 (12): 111388. ( PubMed , DOI )

  10. Masahiro Shimizu, Hiroshi Shibuya: WNK1/HSN2 mediates neurite outgrowth and differentiation via a OSR1/GSK3β-LHX8 pathway. Sci Rep. 2022.09; 12 (1): ( PubMed , DOI )

  11. Ichijo R, Maki K, Kabata M, Murata T, Nagasaka A, Ishihara S, Haga H, Honda T, Adachi T, Yamamoto T, Toyoshima F.: Vasculature atrophy causes a stiffened microenvironment that augments epidermal stem cell differentiation in aged skin Nature Aging. 2022.07; 2 (7): ( DOI )

  12. Hirotoshi Soyama, Miki Nishio, Junji Otani, Toshiko Sakuma, Shintaro Takao, Shigeo Hara, Takaaki Masuda, Koshi Mimori, Shinya Toyokuni, John P Lydon, Kazuwa Nakao, Hiroshi Nishina, Takumi Fukumoto, Tomohiko Maehama, Akira Suzuki: Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers. Proc Natl Acad Sci U S A. 2022.07; 119 (29): e2123134119. ( PubMed , DOI )

  13. Hiroshi Nishina: Physiological and pathological roles of the Hippo-YAP/TAZ signaling pathway in liver formation, homeostasis, and tumorigenesis. Cancer Sci. 2022.06; 113 (6): 1900-1908. ( PubMed , DOI )

  14. Yoshitaka Murota, Kouichi Tabu, Tetsuya Taga: Cancer Stem Cell-Associated Immune Microenvironment in Recurrent Glioblastomas Cells. 2022.06; 11 (13): 2054.

  15. Hashimoto Daiki, Fujimoto Kota, Morioka Shin, Ayabe Shinya, Kataoka Tomoya, Fukumura Ryutaro, Ueda Yuko, Kajimoto Mizuki, Hyuga Taiju, Suzuki Kentaro, Hara Isao, Asamura Shinichi, Wakana Shigeharu, Yoshiki Atsushi, Gondo Yoichi, Tamura Masaru, Sasaki Takehiko, Yamada Gen: 誘導性持続勃起症様表現型を示すマウス系統の樹立(Establishment of mouse line showing inducible priapism-like phenotypes) Reproductive Medicine and Biology. 2022.06; 21 (1): 1 of 11-11 of 11. ( ichushi )

  16. Takeaki Shibata, Hiroki Kawana, Yuri Nishino, Yoshiko Ito, Hiroyasu Sato, Hirofumi Onishi, Kuniyuki Kano, Asuka Inoue, Yoshitaka Taketomi, Makoto Murakami, Satoshi Kofuji, Hiroshi Nishina, Atsuo Miyazawa, Nozomu Kono, Junken Aoki: Abnormal male reproduction and embryonic development induced by downregulation of a phospholipid fatty acid-introducing enzyme Lpgat1 in zebrafish. Sci Rep. 2022.05; 12 (1): 7312. ( PubMed , DOI )

  17. Goto T, Michiue T, Shibuya H: ccr7 affects both morphogenesis and differentiation during early Xenopus embryogenesis. Development, growth & differentiation. 2022.05; 64 (5): 254-260. ( PubMed , DOI )

  18. Ochiai Y, Suzuki C, Segawa K, Uchiyama Y, Nagata S: Inefficient development of syncytiotrophoblasts in the Atp11a-deficient mouse placenta. Proceedings of the National Academy of Sciences of the United States of America. 2022.05; 119 (18): e2200582119. ( PubMed , DOI )

  19. Sinclear Caleb Kwame, Maruyama Junichi, Nagashima Shunta, Arimoto-Matsuzaki Kyoko, Kuleape Joshua Agbemefa, Iwasa Hiroaki, Nishina Hiroshi, Hata Yutaka: Protein kinase Cα activation switches YAP1 from TEAD-mediated signaling to p73-mediated signaling(和訳中) Cancer Science. 2022.04; 113 (4): 1305-1320. ( ichushi )

  20. Caleb Kwame Sinclear, Junichi Maruyama, Shunta Nagashima, Kyoko Arimoto-Matsuzaki, Joshua Agbemefa Kuleape, Hiroaki Iwasa, Hiroshi Nishina, Yutaka Hata: Protein kinase Cα activation switches YAP1 from TEAD-mediated signaling to p73-mediated signaling. Cancer Sci. 2022.04; 113 (4): 1305-1320. ( PubMed , DOI )

  21. Hasegawa J, Tokuda E, Yao Y, Sasaki T, Inoki K, Weisman LS: PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity. Molecular biology of the cell. 2022.03; 33 (3): ar26. ( PubMed , DOI )

  22. Satoshi Kozuki, Satoko Sakurai, Atsushi Suzuki, Takuya Yamamoto, Fumiko Toyoshima: Delineation of biliary epithelial cell dynamics in maternal liver during pregnancy Genes to Cells. 2022.03; 27 (3): ( DOI )

  23. Miyata Yugo, Tokumoto Shoko, Arai Tomohiko, Shaikhutdinov Nurislam, Deviatiiarov Ruslan, Fuse Hiroto, Gogoleva Natalia, Garushyants Sofya, Cherkasov Alexander, Ryabova Alina, Gazizova Guzel, Cornette Richard, Shagimardanova Elena, Gusev Oleg, Kikawada Takahiro: Identification of Genomic Safe Harbors in the Anhydrobiotic Cell Line, Pv11 GENES. 2022.03; 13 (3): ( PubMed , DOI )

  24. High quality genome assembly of the anhydrobiotic midge provides insights on a single chromosome-based emergence of extreme desiccation tolerance 2022.03; 4 (2): ( DOI )

  25. Shimizu M, Shibuya H, Tanaka N: Enhanced O-GlcNAc modification induced by the RAS/MAPK/CDK1 pathway is required for SOX2 protein expression and generation of cancer stem cells. Scientific reports. 2022.02; 12 (1): 2910. ( PubMed , DOI )

  26. Joshua Agbemefa Kuleape, Shakhawoat Hossain, Caleb Kwame Sinclear, Takanobu Shimizu, Hiroaki Iwasa, Junichi Maruyama, Kyoko Arimoto-Matsuzaki, Hiroshi Nishina, Yutaka Hata: DNA Damage Triggers the Nuclear Accumulation of RASSF6 Tumor Suppressor Protein via CDK9 and BAF53 To Regulate p53 Target Gene Transcription. Mol Cell Biol. 2022.02; 42 (2): e0031021. ( PubMed , DOI )

  27. Morioka S, Nakanishi H, Yamamoto T, Hasegawa J, Tokuda E, Hikita T, Sakihara T, Kugii Y, Oneyama C, Yamazaki M, Suzuki A, Sasaki J, Sasaki T: A mass spectrometric method for in-depth profiling of phosphoinositide regioisomers and their disease-associated regulation. Nature communications. 2022.01; 13 (1): 83. ( PubMed , DOI )

  28. Asami Kawasaki, Akiko Sakai, Hiroki Nakanishi, Junya Hasegawa, Tomohiko Taguchi, Junko Sasaki, Hiroyuki Arai, Takehiko Sasaki, Michihiro Igarashi, Fubito Nakatsu: PI4P/PS countertransport by ORP10 at ER-endosome membrane contact sites regulates endosome fission. J Cell Biol. 2022.01; 221 (1): ( PubMed , DOI )

  29. Aimaitijiang Alapati, Tabu Kouichi, Wang Wenqian, Nobuhisa Ikuo, Taga Tetsuya: Glioma cells remotely promote erythropoiesis as a self-expanding strategy of cancer stem cells GENES TO CELLS. 2022.01; 27 (1): 25-42. ( PubMed , DOI )

  30. Shoko Miyata, Noriaki Saku, Saeko Akiyama, Palaksha Kanive Javaregowda, Kenta Ite, Nagisa Takashima, Masashi Toyoda, Kei Yura, Tohru Kimura, Hiroshi Nishina, Atsuko Nakazawa, Mureo Kasahara, Hidenori Nonaka, Tohru Kiyono, Akihiro Umezawa: Puromycin-based purification of cells with high expression of the cytochrome P450 CYP3A4 gene from a patient with drug-induced liver injury (DILI). Stem Cell Res Ther. 2022.01; 13 (1): 6. ( PubMed , DOI )

  31. Yazan Alwarawrah, Keiko Danzaki, Amanda G Nichols, Brian E Fee, Cheryl Bock, Gary Kucera, Laura P Hale, Gregory A Taylor, Nancie J MacIver: Irgm1 regulates metabolism and function in T cell subsets. Scientific Reports. 2022.01; 12 (1): 850. ( PubMed , DOI )

  1. Huang M, Koizumi A, Narita S, Nakanishi H, Sato H, Kashima S, Nara T, Kanda S, Numakura K, Saito M, Satoh S, Nanjo H, Sasaki T, Habuchi T: Altering phosphoinositides in high-fat diet-associated prostate tumor xenograft growth. MedComm. 2021.12; 2 (4): 756-764. ( PubMed , DOI )

  2. Cas9-mediated genome editing reveals a significant contribution of calcium signaling pathways to anhydrobiosis in Pv11 cells 2021.12; 11 (1): ( DOI )

  3. Ikeda Yoshiki, Hirayama Akiyoshi, Kofuji Satoshi, Hirota Yoshihisa, Kamata Ryo, Osaka Natsuki, Fujii Yuki, Sasaki Mika, Ikeda Satsuki, Smith Eric P., Bachoo Robert, Soga Tomoyoshi, Sasaki Atsuo T.: SI-MOIRAI: a new method to identify and quantify the metabolic fate of nucleotides(和訳中) The Journal of Biochemistry. 2021.12; 170 (6): 699-711. ( ichushi )

  4. Yukako Oda, Chisato Takahashi, Shota Harada, Shun Nakamura, Daxiao Sun, Kazumi Kiso, Yuko Urata, Hitoshi Miyachi, Yoshinori Fujiyoshi, Alf Honigmann, Seiichi Uchida, Yasushi Ishihama, Fumiko Toyoshima: Discovery of anti-inflammatory physiological peptides that promote tissue repair by reinforcing epithelial barrier formation. Sci Adv. 2021.11; 7 (47): eabj6895. ( PubMed , DOI )

  5. Goto T, Keller R: Preparation of three-notochord explants for imaging analysis of the cell movements of convergent extension during early Xenopus morphogenesis. Development, growth & differentiation. 2021.10; ( PubMed , DOI )

  6. Keisuke Nakatani, Tomohiko Maehama, Miki Nishio, Junji Otani, Keiko Yamaguchi, Miki Fukumoto, Hiroki Hikasa, Shinji Hagiwara, Hiroshi Nishina, Tak Wah Mak, Teruki Honma, Yasumitsu Kondoh, Hiroyuki Osada, Minoru Yoshida, Akira Suzuki: Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation. Cancer Sci. 2021.10; 112 (10): 4303-4316. ( PubMed , DOI )

  7. Nakatani Keisuke, Maehama Tomohiko, Nishio Miki, Otani Junji, Yamaguchi Keiko, Fukumoto Miki, Hikasa Hiroki, Hagiwara Shinji, Nishina Hiroshi, Mak Tak Wah, Honma Teruki, Kondoh Yasumitsu, Osada Hiroyuki, Yoshida Minoru, Suzuki Akira: アラントラクトンは活性酸素種の蓄積を促進することによりYAP1/TAZを強力に阻害する天然物である(Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation) Cancer Science. 2021.10; 112 (10): 4303-4316. ( ichushi )

  8. Alifu Yikelamu, Kofuji Satoshi, Sunaga Sachi, Kusaba Mizuki, Hirayama Jun, Nishina Hiroshi: The Light-Inducible Genes Per2, Cry1a, and Cry2a Regulate Oxidative Status in Zebrafish(和訳中) Biological & Pharmaceutical Bulletin. 2021.08; 44 (8): 1160-1165. ( ichushi )

  9. Alifu Y, Kofuji S, Sunaga S, Kusaba M, Hirayama J, Nishina H: The Light-Inducible Genes Per2, Cry1a, and Cry2a Regulate Oxidative Status in Zebrafish. Biological & pharmaceutical bulletin. 2021.08; 44 (8): 1160-1165. ( PubMed , DOI )

  10. Sunaga S, Kofuji S, Nishina H: YAP drives cell competition by activating choline metabolism. Biochemical and biophysical research communications. 2021.08; 572 178-184. ( PubMed , DOI )

  11. Ikeda Y, Hirayama A, Kofuji S, Hirota Y, Kamata R, Osaka N, Fujii Y, Sasaki M, Ikeda S, Smith EP, Bachoo R, Soga T, Sasaki AT: SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides. Journal of biochemistry. 2021.07; 170 (6): 699-711. ( PubMed , DOI )

  12. Ichiro Fukunaga, Yoko Oe, Keiko Danzaki, Sayaka Ohta, Cheng Chen, Kyoko Shirai, Atsushi Kawano, Katsuhisa Ikeda, Kazusaku Kamiya: Modeling gap junction beta 2 gene-related deafness with human iPSC. Human Molecular Genetics. 2021.07; 30 (15): 1429-1442. ( PubMed , DOI )

  13. Takako Ooshio, Masahiro Yamamoto, Kiyonaga Fujii, Bing Xin, Kenji Watanabe, Masanori Goto, Yoko Okada, Akira Suzuki, Josef M Penninger, Hiroshi Nishina, Yuji Nishikawa: Hepatocyte Mitogen-Activated Protein Kinase Kinase 7 Contributes to Restoration of the Liver Parenchyma Following Injury in Mice. Hepatology. 2021.06; 73 (6): 2510-2526. ( PubMed , DOI )

  14. Genome-Wide Role of HSF1 in Transcriptional Regulation of Desiccation Tolerance in the Anhydrobiotic Cell Line, Pv11. 2021.05; 22 (11): ( PubMed , DOI )

  15. Nagashima S, Maruyama J, Honda K, Kondoh Y, Osada H, Nawa M, Nakahama KI, Ishigami-Yuasa M, Kagechika H, Sugimura H, Iwasa H, Arimoto-Matsuzaki K, Nishina H, Hata Y: CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells. The Journal of biological chemistry. 2021.05; 297 (1): 100803. ( PubMed , DOI )

  16. Ichiro Fukunaga, Yoko Oe, Keiko Danzaki, Sayaka Ohta, Cheng Chen, Madoka Iizumi, Takahiro Shiga, Rina Matsuoka, Takashi Anzai, Remi Hibiya-Motegi, Shori Tajima, Katsuhisa Ikeda, Wado Akamatsu, Kazusaku Kamiya: Generation of two iPSC lines from siblings of a homozygous patient with hearing loss and a heterozygous carrier with normal hearing carrying p.G45E/Y136X mutation in GJB2. Stem Cell Research. 2021.05; 53 102290. ( PubMed , DOI )

  17. Ichiro Fukunaga, Yoko Oe, Cheng Chen, Keiko Danzaki, Sayaka Ohta, Akito Koike, Katsuhisa Ikeda, Kazusaku Kamiya: Differentiation of Embryonic Stem Cells. Frontiers in Cell and Developmental Biology. 2021.04; 9 602197. ( PubMed , DOI )

  18. M Elizabeth Deerhake, Keiko Danzaki, Makoto Inoue, Emre D Cardakli, Toshiaki Nonaka, Nupur Aggarwal, William E Barclay, Ru-Rong Ji, Mari L Shinohara: Dectin-1 limits autoimmune neuroinflammation and promotes myeloid cell-astrocyte crosstalk via Card9-independent expression of Oncostatin M. Immunity. 2021.03; 54 (3): 484-498.e8. ( PubMed , DOI )

  19. Suzuki I, Yoshida S, Tabu K, Kusunoki S, Matsumura Y, Izumi H, Asanoma K, Yagi H, Onoyama I, Sonoda K, Kohno K, Taga T, Takeda S, Kato K: YBX2 and cancer testis antigen 45 contribute to stemness, chemoresistance and a high degree of malignancy in human endometrial cancer Scientific Reports. 2021.02; 11 (1): 4220.

  20. Ryo Ichijo, Mio Kabata, Hiroyasu Kidoya, Fumitaka Muramatsu, Riki Ishibashi, Kota Abe, Ko Tsutsui, Hirokazu Kubo, Yui Iizuka, Satsuki Kitano, Hitoshi Miyachi, Yoshiaki Kubota, Hironobu Fujiwara, Aiko Sada, Takuya Yamamoto, Fumiko Toyoshima: Vasculature-driven stem cell population coordinates tissue scaling in dynamic organs Science Advances. 2021.02; 7 (7): eabd2575. ( PubMed , DOI )

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  22. Xinliang Jiang, Junichi Maruyama, Hiroaki Iwasa, Kyoko Arimoto-Matsuzaki, Hiroshi Nishina, Yutaka Hata: Heat shock induces the nuclear accumulation of YAP1 via SRC. Exp Cell Res. 2021.02; 399 (1): 112439. ( PubMed , DOI )

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  24. Daiki Hashimoto, Tsuyoshi Hirashima, Hisao Yamamura, Tomoya Kataoka, Kota Fujimoto, Taiju Hyuga, Atsushi Yoshiki, Kazunori Kimura, Shunsuke Kuroki, Makoto Tachibana, Kentaro Suzuki, Nobuhiko Yamamoto, Shin Morioka, Takehiko Sasaki, Gen Yamada: Dynamic erectile responses of a novel penile organ model utilizing two photon excitation microscopy (TPEM)†. Biology of reproduction. 2021.01; ( PubMed , DOI )

  1. Anani M, Nobuhisa I, Taga T: Sry-related High Mobility Group Box 17 Functions as a Tumor Suppressor by Antagonizing the Wingless-related Integration Site Pathway. Journal of Cancer Prevention. 2020.12; 25 (4): 204-212. ( PubMed , DOI )

  2. Sato Atsushi, Shimizu Masahiro, Goto Toshiyasu, Masuno Hiroyuki, Kagechika Hiroyuki, Tanaka Nobuyuki, Shibuya Hiroshi: WNK regulates Wnt signalling and beta-Catenin levels by interfering with the interaction between beta-Catenin and GID COMMUNICATIONS BIOLOGY. 2020.11; 3 (1): ( DOI )

  3. Nishio Miki, To Yoko, Maehama Tomohiko, Aono Yukari, Otani Junji, Hikasa Hiroki, Kitagawa Akihiro, Mimori Koshi, Sasaki Takehiko, Nishina Hiroshi, Toyokuni Shinya, Lydon John P., Nakao Kazuwa, Mak Tak Wah, Kiyono Tohru, Katabuchi Hidetaka, Tashiro Hironori, Suzuki Akira: Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice(和訳中) Cancer Science. 2020.10; 111 (10): 3576-3587. ( ichushi )

  4. Kofuji Satoshi, Sasaki Atsuo T.: GTP metabolic reprogramming by IMPDH2: unlocking cancer cells' fuelling mechanism(和訳中) The Journal of Biochemistry. 2020.10; 168 (4): 319-328. ( ichushi )

  5. Taga T and Tabu K: Glioma progression and recurrence involving maintenance and expansion strategies of glioma stem cells by organizing self-advantageous niche microenvironments. Inflammation and Regeneration. 2020.09; 40 33. ( DOI )

  6. Hanayo Nakanishi, Tomohiro Nishizawa, Katsumori Segawa, Osamu Nureki, Yoshinori Fujiyoshi, Shigekazu Nagata, Kazuhiro Abe: Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM. Cell Rep. 2020.09; 32 (13): 108208. ( PubMed , DOI )

  7. Takahashi S, Nobuhisa I, Saito K, Melig G, Itabashi A, Harada K, Osawa M, Endo AT, Iwama A,Taga T: Sox17-mediated expression of adherent molecules is required for the maintenance of undifferentiated hematopoietic cluster formation in midgestation mouse embryos Differentiation. 2020.09; 115 53-61. ( DOI )

  8. Takanobu Shimizu, Takeshi Nakamura, Hironori Inaba, Hiroaki Iwasa, Junichi Maruyama, Kyoko Arimoto-Matsuzaki, Takao Nakata, Hiroshi Nishina, Yutaka Hata: The RAS-interacting chaperone UNC119 drives the RASSF6-MDM2-p53 axis and antagonizes RAS-mediated malignant transformation. J. Biol. Chem.. 2020.08; 295 (32): 11214-11230. ( PubMed , DOI )

  9. Yamamoto Eiji, Sasaki Junko, Sasaki Takehiko, Sansom Mark S. P.: Effect of lipid quality on the association of membrane bound proteins with phosphoinositidecontaining membranes(和訳中) 生物物理. 2020.08; 60 (Suppl.1-2): S225. ( ichushi )

  10. Riki Ishibashi, Kota Abe, Nanami Ido, Satsuki Kitano, Hitoshi Miyachi, Fumiko Toyoshima: Genome editing with the donor plasmid equipped with synthetic crRNA-target sequence Scientific Reports. 2020.08; 10 (1): ( DOI )

  11. Tabu K, Liu W, Kosaku A, Terashima K, Murota Y, Aimaitijiang A, Nobuhisa I, Hide T, Taga T: Glioma stem cell (GSC)-derived autoschizis-like products confer GSC niche properties involving M1-like tumor-associated macrophages. Stem cells (Dayton, Ohio). 2020.08; 38 (8): 921-935. ( PubMed , DOI )

  12. Hanayo Nakanishi, Katsumasa Irie, Katsumori Segawa, Kazuya Hasegawa, Yoshinori Fujiyoshi, Shigekazu Nagata, Kazuhiro Abe: Crystal structure of a human plasma membrane phospholipid flippase. J Biol Chem. 2020.07; 295 (30): 10180-10194. ( PubMed , DOI )

  13. Nishio M, To Y, Maehama T, Aono Y, Otani J, Hikasa H, Kitagawa A, Mimori K, Sasaki T, Nishina H, Toyokuni S, Lydon JP, Nakao K, Wah Mak T, Kiyono T, Katabuchi H, Tashiro H, Suzuki A: Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice. Cancer science. 2020.07; 111 (10): 3576-3587. ( PubMed , DOI )

  14. Kofuji S, Sasaki AT: GTP Metabolic Reprogramming by IMPDH2: Unlocking Cancer Cells' Fueling Mechanism. Journal of biochemistry. 2020.07; 168 (4): 319-328. ( PubMed , DOI )

  15. Ichiro Fukunaga, Kyoko Shirai, Yoko Oe, Keiko Danzaki, Sayaka Ohta, Takahiro Shiga, Cheng Chen, Katsuhisa Ikeda, Wado Akamatsu, Atsushi Kawano, Kazusaku Kamiya: Generation of two induced pluripotent stem cell lines from PBMCs of siblings carrying c.235delC mutation in the GJB2 gene associated with sensorineural hearing loss. Stem Cell Research. 2020.07; 47 101910. ( PubMed , DOI )

  16. Erika Ishihara, Yuya Nagaoka, Toshiaki Okuno, Satoshi Kofuji, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Kenya Kamimura, Shuji Terai, Takehiko Yokomizo, Yukihiko Sugimoto, Yasuyuki Fujita, Akira Suzuki, Hiroshi Nishina: Prostaglandin E2 and its receptor EP2 trigger signaling that contributes to YAP-mediated cell competition. Genes Cells. 2020.03; 25 (3): 197-214. ( PubMed , DOI )

  17. Hanzawa N, Hashimoto K, Yuan X, Kawahori K, Tsujimoto K, Hamaguchi M, Tanaka T, Nagaoka Y, Nishina H, Morita S, Hatada I, Yamada T, Ogawa Y: Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing. Scientific reports. 2020.03; 10 (1): 5181. ( PubMed , DOI )

  18. Kenya Kamimura, Takeshi Yokoo, Hiroyuki Abe, Norihiro Sakai, Takuro Nagoya, Yuji Kobayashi, Masato Ohtsuka, Hiromi Miura, Akira Sakamaki, Hiroteru Kamimura, Norio Miyamura, Hiroshi Nishina, Shuji Terai: Effect of Diphtheria Toxin-Based Gene Therapy for Hepatocellular Carcinoma. Cancers (Basel). 2020.02; 12 (2): ( PubMed , DOI )

  19. Shori Tajima, Keiko Danzaki, Katsuhisa Ikeda, Kazusaku Kamiya: Degradation and modification of cochlear gap junction proteins in the early development of age-related hearing loss. Experimental & Molecular Medicine. 2020.01; 52 (1): 166-175. ( PubMed , DOI )

  20. Manami Kodaka, Fengju Mao, Kyoko Arimoto-Matsuzaki, Masami Kitamura, Xiaoyin Xu, Zeyu Yang, Kentaro Nakagawa, Junichi Maruyama, Kana Ishii, Chihiro Akazawa, Takuya Oyaizu, Naoki Yamamoto, Mari Ishigami-Yuasa, Nozomi Tsuemoto, Shigeru Ito, Hiroyuki Kagechika, Hiroshi Nishina, Yutaka Hata: Characterization of a novel compound that promotes myogenesis via Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells. PLoS ONE. 2020; 15 (4): e0231265. ( PubMed , DOI )

  21. Hirofumi Omori, Miki Nishio, Muneyuki Masuda, Yosuke Miyachi, Fumihito Ueda, Takafumi Nakano, Kuniaki Sato, Koshi Mimori, Kenichi Taguchi, Hiroki Hikasa, Hiroshi Nishina, Hironori Tashiro, Tohru Kiyono, Tak Wah Mak, Kazuwa Nakao, Takashi Nakagawa, Tomohiko Maehama, Akira Suzuki: YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma. Sci Adv. 2020; 6 (12): eaay3324. ( PubMed , DOI )

  22. Okamoto-Uchida Yoshimi, Nishimura Akari, Izawa Junko, Hattori Atsuhiko, Suzuki Nobuo, Hirayama Jun: The Use of Chemical Compounds to Identify the Regulatory Mechanisms of Vertebrate Circadian Clocks CURRENT DRUG TARGETS. 2020; 21 (5): 425-432. ( PubMed , DOI )

  23. Low melting point agarose (LMPA)-immobilization method to improve functional assay of olfactory receptors in Sf9 cells 2020; ( DOI )

  1. Ryo Goto, Kenya Kamimura, Yoko Shinagawa-Kobayashi, Norihiro Sakai, Takuro Nagoya, Yusuke Niwa, Masayoshi Ko, Kohei Ogawa, Ryosuke Inoue, Takeshi Yokoo, Akira Sakamaki, Hiroteru Kamimura, Satoshi Abe, Hiroshi Nishina, Shuji Terai: Inhibition of sodium glucose cotransporter 2 (SGLT2) delays liver fibrosis in a medaka model of nonalcoholic steatohepatitis (NASH). FEBS Open Bio. 2019.12; 9 (4): 643-652. ( PubMed , DOI )

  2. 1. Kawai T, Miyata H, Nakanishi H, Sakata S, Morioka S, Sasaki J, Watanabe M, Sakimura K, Fujimoto T, Sasaki T, Ikawa M & Okamura Y.: PtdIns(4,5)P2 Distribution Mediated by a Voltage-Sensing Phosphatase (VSP) Regulates Sperm Motility. Proc. Natl. Acad. Sci. USA. 2019.12; 116 (51): 26020-26028. ( DOI )

  3. Takuro Nagoya, Kenya Kamimura, Ryo Goto, Yoko Shinagawa-Kobayashi, Yusuke Niwa, Atsushi Kimura, Norihiro Sakai, Masayoshi Ko, Hiroshi Nishina, Shuji Terai: Inhibition of sodium-glucose cotransporter 2 ameliorates renal injury in a novel medaka model of nonalcoholic steatohepatitis-related kidney disease. FEBS Open Bio. 2019.12; 9 (12): 2016-2024. ( PubMed , DOI )

  4. Fujioka Yoichiro, Satoh Aya O., Horiuchi Kosui, Fujioka Mari, Tsutsumi Kaori, Sasaki Junko, Nepal Prabha, Kashiwagi Sayaka, Paudel Sarad, Nishide Shinya, Nanbo Asuka, Sasaki Takehiko, Ohba Yusuke: A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection(和訳中) Cell Structure and Function. 2019.12; 44 (1-2): 61-74. ( ichushi )

  5. Ichiro Fukunaga, Takahiro Shiga, Cheng Chen, Yoko Oe, Keiko Danzaki, Sayaka Ohta, Rina Matsuoka, Takashi Anzai, Remi Hibiya-Motegi, Shori Tajima, Katsuhisa Ikeda, Wado Akamatsu, Kazusaku Kamiya: Generation of the induced pluripotent stem cell (hiPSC) line (JUFMDOi004-A) from a patient with hearing loss carrying GJB2 (p.V37I) mutation. Stem Cell Research. 2019.12; 43 101674. ( PubMed , DOI )

  6. Kawai T, Miyata H, Nakanishi H, Sakata S, Morioka S, Sasaki J, Watanabe M, Sakimura K, Fujimoto T, Sasaki T, Ikawa M, Okamura Y: Polarized PtdIns(4,5)P2 distribution mediated by a voltage-sensing phosphatase (VSP) regulates sperm motility. Proceedings of the National Academy of Sciences of the United States of America. 2019.11; ( PubMed , DOI )

  7. Nobuhisa Ikuo, Saito Kiyoka, Tsukahara Ryota, Azuma Koya, Melig Gerel, Itabashi Ayumi, Taga Tetsuya: Hematopoiesis and Immune Environment　Involvement of TET1 inthe maintenance of the hematopoietic capacity in hematopoietic cell clusters in the dorsal aorta in midgestation mouse embryo(和訳中) 日本免疫学会総会・学術集会記録. 2019.11; 48 (Proceedings): 1-H. ( ichushi )

  8. Naffouje R, Grover P, Yu H, Sendilnathan A, Wolfe K, Majd N, Smith EP, Takeuchi K, Senda T, Kofuji S, Sasaki AT: Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story. Cancers. 2019.09; 11 (9): ( PubMed , DOI )

  9. Koizumi A, Narita S, Nakanishi H, Ishikawa M, Eguchi S, Kimura H, Takasuga S, Huang M, Inoue T, Sasaki J, Yoshioka T, Habuchi T & Sasaki T.: Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression. Sci Rep. 2019.09; 9 (1): 13257. ( DOI )

  10. 成田 伸太郎, 中西 広樹, 松田 芳教, 小泉 淳, 江口 賢史, 高須賀 俊輔, 黄 明国, 井上 高光, 佐々木 純子, 南条 博, 羽渕 友則, 佐々木 雄彦: 腎癌におけるイノシトールリン脂質発現プロファイル(The expression profile of phosphatidylinositol phosphates in clinical renal cell carcinoma) 日本癌学会総会記事. 2019.09; 78回 P-1154. ( ichushi )

  11. McCormick Barry, Craig Helen E., Chu Julia Y., Carlin Leo M., Canel Marta, Wollweber Florian, Toivakka Matilda, Michael Melina, Astier Anne L., Norton Laura, Lilja Johanna, Felton Jennifer M., Sasaki Takehiko, Ivaska Johanna, Hers Ingeborg, Dransfield Ian, Rossi Adriano G., Vermeren Sonja: A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites JOURNAL OF IMMUNOLOGY. 2019.09; 203 (6): 1579-1588. ( PubMed , DOI )

  12. Koizumi Atsushi, Narita Shintaro, Nakanishi Hiroki, Ishikawa Masaki, Eguchi Satoshi, Kimura Hirotaka, Takasuga Shunsuke, Huang Mingguo, Inoue Takamitsu, Sasaki Junko, Yoshioka Toshiaki, Habuchi Tomonori, Sasaki Takehiko: Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression SCIENTIFIC REPORTS. 2019.09; 9 (1): 13257. ( PubMed , DOI )

  13. AIMAITIJIANG ALAPATI, 椨 康一, 田賀 哲也: グリオーマ幹細胞によるマウス骨髄赤芽球分化の促進(Glioma stem cells modulate erythropoiesis in mouse bone marrow) 日本癌学会総会記事. 2019.09; 78回 P-3065. ( ichushi )

  14. 椨 康一, 田賀 哲也: グリオーマの新規治療標的としての単球動員がん幹細胞の可視化と検証(Visualization and validation of monocyte-recruiting cells as a potential target of glioma stem cells) 日本癌学会総会記事. 2019.09; 78回 P-3064. ( ichushi )

  15. Wolfe K, Kofuji S, Yoshino H, Sasaki M, Okumura K, Sasaki AT: Dynamic compartmentalization of purine nucleotide metabolic enzymes at leading edge in highly motile renal cell carcinoma. Biochemical and biophysical research communications. 2019.08; 516 (1): 50-56. ( PubMed , DOI )

  16. Takemasu S, Nigorikawa K, Yamada M, Tsurumi G, Kofuji S, Takasuga S, Hazeki K: Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning. Journal of biochemistry. 2019.08; 166 (2): 175-185. ( PubMed , DOI )

  17. Kofuji S, Hirayama A, Eberhardt AO, Kawaguchi R, Sugiura Y, Sampetrean O, Ikeda Y, Warren M, Sakamoto N, Kitahara S, Yoshino H, Yamashita D, Sumita K, Wolfe K, Lange L, Ikeda S, Shimada H, Minami N, Malhotra A, Morioka S, Ban Y, Asano M, Flanary VL, Ramkissoon A, Chow LML, Kiyokawa J, Mashimo T, Lucey G, Mareninov S, Ozawa T, Onishi N, Okumura K, Terakawa J, Daikoku T, Wise-Draper T, Majd N, Kofuji K, Sasaki M, Mori M, Kanemura Y, Smith EP, Anastasiou D, Wakimoto H, Holland EC, Yong WH, Horbinski C, Nakano I, DeBerardinis RJ, Bachoo RM, Mischel PS, Yasui W, Suematsu M, Saya H, Soga T, Grummt I, Bierhoff H, Sasaki AT: IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma. Nature cell biology. 2019.08; 21 (8): 1003-1014. ( PubMed , DOI )

  18. Takemasu Shinya, Nigorikawa Kiyomi, Yamada Miho, Tsurumi Go, Kofuji Satoshi, Takasuga Shunsuke, Hazeki Kaoru: Erk/MAPKによるTMEM55Bのリン酸化はリソソームのポジショニングを制御する(Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning) The Journal of Biochemistry. 2019.08; 166 (2): 175-185. ( ichushi )

  19. Sasaki Junko, Eguchi Satoshi, Nakanishi Hiroki, Sasaki Takehiko: Regulation of cell functions by phosphoinositides　Molecular mechanisms of phosphoinositide signaling(和訳中) The Journal of Physiological Sciences. 2019.06; 69 (Suppl.1): S36. ( ichushi )

  20. Kawai Takafumi, Miyata Haruhiko, Nakanishi Hiroki, Sakata Souhei, Okochi Yoshifumi, Watanabe Masahiko, Sakimura Kenji, Sasaki Takehiko, Ikawa Masahito, Okamura Yasushi: Regulation of cell functions by phosphoinositides　Functional analysis of voltage-sensing phosphatase in mouse sperm(和訳中) The Journal of Physiological Sciences. 2019.06; 69 (Suppl.1): S36. ( ichushi )

  21. Nigorikawa Kiyomi, Matsumura Takuma, Sakamoto Hiromi, Morioka Shin, Kofuji Satoshi, Takasuga Shunsuke, Hazeki Kaoru: Sac1ホスホイノシチドホスファターゼは、マクロファージにおけるSR-A発現を調節することにより、泡沫細胞の形成を制御する(Sac1 Phosphoinositide Phosphatase Regulates Foam Cell Formation by Modulating SR-A Expression in Macrophages) Biological & Pharmaceutical Bulletin. 2019.06; 42 (6): 923-928. ( ichushi )

  22. Jennifer Rebeles, William D Green, Yazan Alwarawrah, Amanda G Nichols, William Eisner, Keiko Danzaki, Nancie J MacIver, Melinda A Beck: Obesity-Induced Changes in T-Cell Metabolism Are Associated With Impaired Memory T-Cell Response to Influenza and Are Not Reversed With Weight Loss. The Journal of Infectious Diseases. 2019.04; 219 (10): 1652-1661. ( PubMed , DOI )

  23. Fujioka Y, Satoh AO, Horiuchi K, Fujioka M, Tsutsumi K, Sasaki J, Nepal P, Kashiwagi S, Paudel S, Nishide S, Nanbo A, Sasaki T, Ohba Y: A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection. Cell structure and function. 2019.04; 44 (1): 61-74. ( PubMed , DOI )

  24. Takemasu S, Ito M, Morioka S, Nigorikawa K, Kofuji S, Takasuga S, Eguchi S, Nakanishi H, Matsuoka I, Sasaki J, Sasaki T, Hazeki K: Lysophosphatidylinositol-acyltransferase-1 is involved in cytosolic Ca2+ oscillations in macrophages. Genes to cells : devoted to molecular & cellular mechanisms. 2019.03; ( PubMed , DOI )

  25. Takemasu Shinya、Ito Masaki、Morioka Shin、Nigorikawa Kiyomi、Kofuji Satoshi、Takasuga Shunsuke、Eguchi Satoshi、Nakanishi Hiroki、Matsuoka Isao、Sasaki Junko、Sasaki Takehiko、 Hazeki Kaoru: Lysophosphatidylinositol-acyltransferase-1 is involved in cytosolic Ca2+ oscillations in macrophages. Genes to Cells. 2019.03; 24 (5): 366-376. ( DOI )

  26. Shimizu M, Tanaka N: IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells. Oncogene. 2019.02; 38 (9): 1520-1533. ( PubMed , DOI )

  27. Wang YH, Chen CB, Tassaneeyakul W, Saito Y, Aihara M, Choon SE, Lee HY, Chang MM, Roa FD, Wu CW, Zhang J, Nakkam N, Konyoung P, Okamoto-Uchida Y, Cheung CM, Huang JW, Ji C, Cheng B, Hui RC, Chu CY, Chen YJ, Wu CY, Hsu CK, Chiu TM, Huang YH, Lu CW, Yang CY, Lin YT, Chi MH, Ho HC, Lin JY, Yang CH, Chang YC, Su SC, Wang CW, Fan WL, Hung SI, Chung WH, Asian Severe Cutaneous Adverse Reaction Consortium.: The Medication Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Asians: The Major Drug Causality and Comparison With the US FDA Label. Clinical pharmacology and therapeutics. 2019.01; 105 (1): 112-120. ( PubMed , DOI )

  28. Isobe Y, Nigorikawa K, Tsurumi G, Takemasu S, Takasuga S, Kofuji S, Hazeki K: PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel. Journal of biochemistry. 2019.01; 165 (1): 75-84. ( PubMed , DOI )

  29. Hirayama J, Alifu Y, Hamabe R, Yamaguchi S, Tomita J, Maruyama Y, Asaoka Y, Nakahama KI, Tamaru T, Takamatsu K, Takamatsu N, Hattori A, Nishina S, Azuma N, Kawahara A, Kume K, Nishina H: The clock components Period2, Cryptochrome1a, and Cryptochrome2a function in establishing light-dependent behavioral rhythms and/or total activity levels in zebrafish. Scientific reports. 2019.01; 9 (1): 196. ( PubMed , DOI )

  30. Isobe Yuri, Nigorikawa Kiyomi, Tsurumi Go, Takemasu Shinya, Takasuga Shunsuke, Kofuji Satoshi, Hazeki Kaoru: PIKfyveはTRPML1活性化を介してファゴソーム酸性化を促進するが、Ca2+チャネルとは無関係に異常な空胞形成を阻止する(PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel) The Journal of Biochemistry. 2019.01; 165 (1): 75-84. ( ichushi )

  31. Miki Nishio, Yousuke Miyachi, Junji Otani, Shoji Tane, Hirofumi Omori, Fumihito Ueda, Hideru Togashi, Takehiko Sasaki, Tak Wah Mak, Kazuwa Nakao, Yasuyuki Fujita, Hiroshi Nishina, Tomohiko Maehama, Akira Suzuki: Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency. FASEB J.. 2019.01; 33 (4): fj201802005R. ( PubMed , DOI )

  32. Yoshino H, Yin G, Kawaguchi R, Popov KI, Temple B, Sasaki M, Kofuji S, Wolfe K, Kofuji K, Okumura K, Randhawa J, Malhotra A, Majd N, Ikeda Y, Shimada H, Kahoud ER, Haviv S, Iwase S, Asara JM, Campbell SL, Sasaki AT: Correction: Identification of lysine methylation in the core GTPase domain by GoMADScan. PloS one. 2019; 14 (10): e0224443. ( PubMed , DOI )

  33. Yoshino H, Yin G, Kawaguchi R, Popov KI, Temple B, Sasaki M, Kofuji S, Wolfe K, Kofuji K, Okumura K, Randhawa J, Malhotra A, Majd N, Ikeda Y, Shimada H, Kahoud ER, Haviv S, Iwase S, Asara JM, Campbell SL, Sasaki AT: Identification of lysine methylation in the core GTPase domain by GoMADScan. PloS one. 2019; 14 (8): e0219436. ( PubMed , DOI )

  34. Nigorikawa K, Matsumura T, Sakamoto H, Morioka S, Kofuji S, Takasuga S, Hazeki K: Sac1 Phosphoinositide Phosphatase Regulates Foam Cell Formation by Modulating SR-A Expression in Macrophages. Biological & pharmaceutical bulletin. 2019; 42 (6): 923-928. ( PubMed , DOI )

  35. The Physiological Functions of a Model Peptide of G3LEA in Living Cells 2019; ( DOI )

  36. Fujioka Yoichiro, Satoh Aya O., Horiuchi Kosui, Fujioka Mari, Tsutsumi Kaori, Sasaki Junko, Nepal Prabha, Kashiwagi Sayaka, Paudel Sarad, Nishide Shinya, Nanbo Asuka, Sasaki Takehiko, Ohba Yusuke: A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection CELL STRUCTURE AND FUNCTION. 2019; 44 (1): 61-74.

  37. Yu-Hsin Wang, Chun-Bing Chen, Wichittra Tassaneeyakul, Yoshiro Saito, Michiko Aihara, Siew Eng Choon, Haur Yueh Lee, Mimi Mee Chang, Francisca D Roa, Cheng-Wei Wu, Jing Zhang, Nontaya Nakkam, Parinya Konyoung, Yoshimi Okamoto-Uchida, Christina Man-Tung Cheung, Jin-Wen Huang, Chao Ji, Bo Cheng, Rosaline Chung-Yee Hui, Chia-Yu Chu, Yi-Ju Chen, Ching-Ying Wu, Chao-Kai Hsu, Tsu-Man Chiu, Yu-Huei Huang, Chun-Wei Lu, Chin-Yi Yang, Yi-Ting Lin, Min-Hui Chi, Hsin-Chun Ho, Jing-Yi Lin, Chih-Hsun Yang, Ya-Ching Chang, Shih-Chi Su, Chuang Wei Wang, Wen-Lang Fan, Shuen-Iu Hung, Wen-Hung Chung, : The Medication Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Asians: The Major Drug Causality and Comparison With the US FDA Label. Clin Pharmacol Ther. 2019; 105 (1): 112-120.

  1. Nishita M., Nishikaku I., Yoshida E., Kamizaki K., Shibuya H., Matsumoto K., Minami Y.: Roil promotes invasion of lung adenocarcinoma cells through small GTPase Rif-mediated filopodia formation MOLECULAR BIOLOGY OF THE CELL. 2018.12; 29 (26): 231.

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  3. Espiritu EB, Crunk AE, Bais A, Hochbaum D, Cervino AS, Phua YL, Butterworth MB, Goto T, Ho J, Hukriede NA, Cirio MC: The Lhx1-Ldb1 complex interacts with Furry to regulate microRNA expression during pronephric kidney development. Scientific reports. 2018.10; 8 (1): 16029. ( PubMed , DOI )

  4. 小泉 淳, 成田 伸太郎, 中西 広樹, 奈良 健平, 神田 壮平, 沼倉 一幸, 黄 明国, 齋藤 満, 井上 高光, 佐藤 滋, 吉岡 年明, 羽渕 友則, 佐々木 雄彦: 前立腺癌におけるホスファチジルイノシトールリン酸プロファイルの解析(Phosphatidylinositol phosphate profiles in pre-clinical and clinical prostate cancer) 日本癌学会総会記事. 2018.09; 77回 1444. ( ichushi )

  5. 椨 康一, 田賀 哲也: グリオーマにおける単球動員亜集団は幹細胞性と薬剤耐性を有する(A monocyte-recruiting phenotype defines functional heterogeneity of glioma cells with stemness and chemoresistance) 日本癌学会総会記事. 2018.09; 77回 2314. ( ichushi )

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  8. Hirotaka Kimura, Yasushi Matsuyama, Sachiko Araki, Atsushi Koizumi, Yumi Kariya, Shunsuke Takasuga, Satoshi Eguchi, Hiroki Nakanishi, Junko Sasaki, Takehiko Sasaki: The effect and possible clinical efficacy of in vivo inhibition of neutrophil extracellular traps by blockade of PI3K-gamma on the pathogenesis of microscopic polyangiitis. Mod Rheumatol. 2018.05; 28 (3): 530-541. ( PubMed , DOI )

  9. Marc C Liggins, Jessica L Flesher, Sohail Jahid, Priya Vasudeva, Victoria Eby, Shunsuke Takasuga, Junko Sasaki, Takehiko Sasaki, Raymond E Boissy, Anand K Ganesan: PIKfyve regulates melanosome biogenesis. PLoS Genet.. 2018.05; 14 (3): e1007290. ( PubMed , DOI )

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  1. Imatoh T, Sai K, Fukazawa C, Hinomura Y, Nakamura R, Okamoto-Uchida Y, Segawa K, Saito Y: Association between infection and severe drug adverse reactions: an analysis using data from the Japanese Adverse Drug Event Report database. European journal of clinical pharmacology. 2017.12; 73 (12): 1643-1653. ( PubMed , DOI )

  2. 齋藤 清香, 信久 幾夫, 田賀 哲也: マウス胎生中期AGM領域の未分化血球系細胞塊におけるSox17とTETファミリーによる未分化性維持機構の解明 生命科学系学会合同年次大会. 2017.12; 2017年度 [2P-0781]. ( ichushi )

  3. Ikuo Nobuhisa, Takahishi Satomi, Saito Kiyoka, Taga Tetsuya: 癌免疫療法における免疫応答　妊娠中期マウス胚の大動脈内造血細胞クラスター形成における転写因子Sox17によって誘導される接着分子の役割(Hematopoiesis and immune environments　Role of adhesion molecules induced by a transcription factor Sox17 in intra-aortic hematopoietic cell cluster formation in midgestation mouse embryos) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 1-G. ( ichushi )

  4. Mingguo Huang, Shintaro Narita, Takamitsu Inoue, Atsushi Koizumi, Mitsuru Saito, Hiroshi Tsuruta, Kazuyuki Numakura, Shigeru Satoh, Hiroshi Nanjo, Takehiko Sasaki, Tomonori Habuchi: Fatty acid binding protein 4 enhances prostate cancer progression by upregulating matrix metalloproteinases and stromal cell cytokine production. Oncotarget. 2017.12; 8 (67): 111780-111794. ( PubMed , DOI )

  5. 劉 瀟瀟, 合山 進, 四方 紫織, 林 康貴, 岩村 浩幸, 齊藤 基輝, 杉浦 悠毅, 滝澤 仁, 小藤 智史, 壽美田 一貴, 佐々木 敦朗, Schibler Janet, Mulloy James C., 北村 俊雄: IMPDH阻害剤による新規白血病治療法の開発 生命科学系学会合同年次大会. 2017.12; 2017年度 [1P-0963]. ( ichushi )

  6. Tatsuyuki Matsudaira, Kojiro Mukai, Taishin Noguchi, Junya Hasegawa, Tomohisa Hatta, Shun-Ichiro Iemura, Tohru Natsume, Norio Miyamura, Hiroshi Nishina, Jun Nakayama, Kentaro Semba, Takuya Tomita, Shigeo Murata, Hiroyuki Arai, Tomohiko Taguchi: Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells. Nat Commun. 2017.11; 8 (1): 1246. ( PubMed , DOI )

  7. Mouhannad Malek, Anna Kielkowska, Tamara Chessa, Karen E Anderson, David Barneda, Pınar Pir, Hiroki Nakanishi, Satoshi Eguchi, Atsushi Koizumi, Junko Sasaki, Véronique Juvin, Vladimir Y Kiselev, Izabella Niewczas, Alexander Gray, Alexandre Valayer, Dominik Spensberger, Marine Imbert, Sergio Felisbino, Tomonori Habuchi, Soren Beinke, Sabina Cosulich, Nicolas Le Novère, Takehiko Sasaki, Jonathan Clark, Phillip T Hawkins, Len R Stephens: PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K. Mol. Cell. 2017.11; 68 (3): 566-580.e10. ( PubMed , DOI )

  8. Okamoto-Uchida Yoshimi, Nakamura Ryosuke, Sai Kimie, Imatoh Takuya, Matsunaga Kayoko, Aihara Michiko, Saito Yoshiro: Stevens-Johnson症候群および中毒性表皮壊死症の病因に及ぼす感染症の影響(Effect of Infectious Diseases on the Pathogenesis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis) Biological & Pharmaceutical Bulletin. 2017.09; 40 (9): 1576-1580. ( ichushi )

  9. Tagawa Hiroyuki, Abe Fumito, Nakanishi Hiroki, Kitadate Akihiro, Ikeda Sho, Takahashi Naoto, Sasaki Takehiko: 脂質定量解析による悪性リンパ腫の新たな診断マーカーの同定(Phosphatidylinositol phosphates profile reveals novel diagnostic marker(s) in malignant lymphoma) 臨床血液. 2017.09; 58 (9): 1742. ( ichushi )

  10. 阿部 史人, 中西 広樹, 北舘 明宏, 池田 翔, 亀岡 吉弘, 高橋 直人, 佐々木 雄彦, 田川 博之: 悪性リンパ腫におけるイノシトールリン脂質プロファイル 日本癌学会総会記事. 2017.09; 76回 P-2236. ( ichushi )

  11. Ryo Ichijo, Hiroki Kobayashi, Saori Yoneda, Yui Iizuka, Hirokazu Kubo, Shigeru Matsumura, Satsuki Kitano, Hitoshi Miyachi, Tetsuya Honda, Fumiko Toyoshima: Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration NATURE COMMUNICATIONS. 2017.09; 8 (1): 508. ( PubMed , DOI )

  12. 室田 吉貴, 椨 康一, 田賀 哲也: p53ノックアウトマウスアストロサイトへのH-RasV12導入によるマウスグリオーマモデルの樹立 日本癌学会総会記事. 2017.09; 76回 P-2120. ( ichushi )

  13. 椨 康一, 室田 吉貴, 田賀 哲也: グリオーマ幹細胞のマクロファージを利用した鉄欠乏ストレスへの適応・生存戦略 日本癌学会総会記事. 2017.09; 76回 P-3156. ( ichushi )

  14. Okamoto-Uchida Yoshimi, Nakamura Ryosuke, Sai Kimie, Imatoh Takuya, Matsunaga Kayoko, Aihara Michiko, Saito Yoshiro: Stevens-Johnson症候群および中毒性表皮壊死症の病因に及ぼす感染症の影響(Effect of Infectious Diseases on the Pathogenesis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis) Biological & Pharmaceutical Bulletin. 2017.09; 40 (9): 1576-1580.

  15. Jun Negishi, Yuka Omori, Mami Shindo, Hayate Takanashi, Shiori Musha, Suminori Nagayama, Jun Hirayama, Hiroshi Nishina, Takashi Nakakura, Chihiro Mogi, Koichi Sato, Fumikazu Okajima, Yuta Mochimaru, Hideaki Tomura: Manganese and cobalt activate zebrafish ovarian cancer G-protein-coupled receptor 1 but not GPR4. J. Recept. Signal Transduct. Res.. 2017.08; 37 (4): 401-408. ( PubMed , DOI )

  16. Tokiwa Yamasaki, Norie Deki-Arima, Asahito Kaneko, Norio Miyamura, Mamiko Iwatsuki, Masato Matsuoka, Noriko Fujimori-Tonou, Yoshimi Okamoto-Uchida, Jun Hirayama, Jamey D Marth, Yuji Yamanashi, Hiroshi Kawasaki, Koji Yamanaka, Josef M Penninger, Shigenobu Shibata, Hiroshi Nishina: Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. Sci Rep. 2017.08; 7 (1): 7348. ( PubMed , DOI )

  17. Harada K, Nobuhisa I, Anani M, Saito K, Taga T: Thrombopoietin contributes to the formation and the maintenance of hematopoietic progenitor-containing cell clusters in the aorta-gonad-mesonephros region. Cytokine. 2017.07; 95 32-42. ( DOI )

  18. Norio Miyamura, Shoji Hata, Tohru Itoh, Minoru Tanaka, Miki Nishio, Michiko Itoh, Yoshihiro Ogawa, Shuji Terai, Isao Sakaida, Akira Suzuki, Atsushi Miyajima, Hiroshi Nishina: YAP determines the cell fate of injured mouse hepatocytes in vivo. Nat Commun. 2017.07; 8 16017. ( PubMed , DOI )

  19. K Otsubo, H Goto, M Nishio, K Kawamura, S Yanagi, W Nishie, T Sasaki, T Maehama, H Nishina, K Mimori, T Nakano, H Shimizu, T W Mak, K Nakao, Y Nakanishi, A Suzuki: MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation. Oncogene. 2017.07; 36 (29): 4201-4211. ( PubMed , DOI )

  20. Masashi Kanayama, Shengjie Xu, Keiko Danzaki, Jason R Gibson, Makoto Inoue, Simon G Gregory, Mari L Shinohara: Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin. Nature Immunology. 2017.07; ( PubMed , DOI )

  21. Yoshiko Iizuka-Hishikawa, Daisuke Hishikawa, Junko Sasaki, Keiyo Takubo, Motohito Goto, Katsuyuki Nagata, Hiroki Nakanishi, Hideo Shindou, Tadashi Okamura, Chizuru Ito, Kiyotaka Toshimori, Takehiko Sasaki, Takao Shimizu: Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis. J. Biol. Chem.. 2017.07; 292 (29): 12065-12076. ( PubMed , DOI )

  22. Hideo Shindou, Hideto Koso, Junko Sasaki, Hiroki Nakanishi, Hiroshi Sagara, Koh M Nakagawa, Yoshikazu Takahashi, Daisuke Hishikawa, Yoshiko Iizuka-Hishikawa, Fuyuki Tokumasu, Hiroshi Noguchi, Sumiko Watanabe, Takehiko Sasaki, Takao Shimizu: Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells. J. Biol. Chem.. 2017.07; 292 (29): 12054-12064. ( PubMed , DOI )

  23. Michiue T, Yamamoto T, Yasuoka Y, Goto T, Ikeda T, Nagura K, Nakayama T, Taira M, Kinoshita T.: High variability of expression profiles of homeologous genes for Wnt, Hh, Notch, and Hippo signaling pathways in Xenopus laevis. Dev Biol.. 2017.06; 426 (2): 270-290. ( PubMed , DOI )

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  25. A G-quadruplex structure at the 5' end of the H19 coding region regulates H19 transcription 2017.04; 7 45815. ( PubMed , DOI )

  26. Essential roles of Tbx3 in embryonic skin development during epidermal stratification 2017.03; 22 (3): 284-292. ( PubMed , DOI )

  27. Dormant Pluripotent Cells Emerge during Neural Differentiation of Embryonic Stem Cells in a FoxO3-Dependent Manner 2017.03; 37 (5): e00417-16. ( PubMed , DOI )

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  29. Seiichiro Mori, Takamasa Takeuchi, Yoshiyuki Ishii, Takashi Yugawa, Tohru Kiyono, Hiroshi Nishina, Iwao Kukimoto: Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor. J. Virol.. 2017.03; 91 (6): ( PubMed , DOI )

  30. Wang W, Tabu K, Hagiya Y, Sugiyama Y, Kokubu Y, Murota Y, Ogura SI, and Taga T: Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation. Sci Rep. 2017.02; 7 42070. ( PubMed , DOI )

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  33. Asaoka Yoichi, Nishina Hiroshi, Furutani-Seiki Makoto: 【発生時のサイズ】YAPは重力に抵抗性の3D器官形成にとって必須である(【Size in development】YAP is essential for 3D organogenesis withstanding gravity) Development, Growth & Differentiation. 2017.01; 59 (1): 52-58. ( ichushi )

  34. Hirotaka Kimura, Satoshi Eguchi, Junko Sasaki, Keiji Kuba, Hiroki Nakanishi, Shunsuke Takasuga, Masakazu Yamazaki, Akiteru Goto, Hiroyuki Watanabe, Hiroshi Itoh, Yumiko Imai, Akira Suzuki, Noboru Mizushima, Takehiko Sasaki: Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy. JCI Insight. 2017.01; 2 (1): e89462. ( PubMed , DOI )

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  1. Murota Y, Tabu K, and Taga T: Requirement of ABC transporter inhibition and Hoechst 33342 dye deprivation for the assessment of side population-defined C6 glioma stem cell metabolism using fluorescent probes. BMC Cancer. 2016.11; 16 847. ( PubMed , DOI )

  2. Okamoto-Uchida Y, Yu R, Miyamura N, Arima N, Ishigami-Yuasa M, Kagechika H, Yoshida S, Hosoya T, Nawa M, Kasama T, Asaoka Y, Alois RW, Elling U, Penninger JM, Nishina S, Azuma N, Nishina H: The mevalonate pathway regulates primitive streak formation via protein farnesylation. Sci Rep. 2016.11; 6 37697. ( PubMed , DOI )

  3. Keiko Danzaki, Masashi Kanayama, Oscar Alcazar, Mari L Shinohara: Osteopontin has a protective role in prostate tumor development in mice. European journal of immunology. 2016.11; 46 (11): 2669-2678. ( PubMed , DOI )

  4. 椨 康一, 王 文茜, 室田 吉貴, 田賀 哲也: C6グリオーマ幹細胞におけるマクロファージ誘導を介した鉄枯渇への適応 日本癌学会総会記事. 2016.10; 75回 J-1031. ( ichushi )

  5. Okamoto-Uchida Yoshimi, Nakamura Ryosuke, Matsuzawa Yumiko, Soma Megumi, Kawakami Hiroshi, Ishii-Watabe Akiko, Nishimaki-Mogami Tomoko, Teshima Reiko, Saito Yoshiro: アレルゲンの固定化に起因するIgE結合および架橋に基づいたアレルギー検査の異なる結果(Different Results of IgE Binding- and Crosslinking-Based Allergy Tests Caused by Allergen Immobilization) Biological & Pharmaceutical Bulletin. 2016.10; 39 (10): 1662-1666. ( ichushi )

  6. 王 文茜, 椨 康一, 萩谷 祐一郎, 室田 吉貴, 小倉 俊一郎, 田賀 哲也: アミノレブリン酸を用いたC6グリオーマ幹細胞の検出に対する鉄キレート剤による向上効果 日本癌学会総会記事. 2016.10; 75回 E-1107. ( ichushi )

  7. Masashi Kanayama, Keiko Danzaki, You-Wen He, Mari L Shinohara: Lung inflammation stalls Th17-cell migration en route to the central nervous system during the development of experimental autoimmune encephalomyelitis. Int. Immunol.. 2016.09; 28 (9): 463-469. ( PubMed , DOI )

  8. Shin Morioka, Kiyomi Nigorikawa, Junko Sasaki, Kaoru Hazeki, Yoshihiro Kasuu, Takehiko Sasaki, Osamu Hazeki: Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model. Innate Immun. 2016.08; 22 (6): 444-451. ( PubMed , DOI )

  9. Kimura T, Wang L, Tabu K, Tsuda M, Tanino M, Maekawa A, Nishihara H, Hiraga H, Taga T, Oda Y, and Tanaka S: Identification and analysis of CXCR4-positive synovial sarcoma-initiating cells. Oncogene. 2016.07; 35 3932-3943.

  10. Kimura T., Wang L., Tabu K., Tsuda M., Tanino M., Maekawa A., Nishihara H., Hiraga H., Taga T., Oda Y., Tanaka S.: Identification and analysis of CXCR4-positive synovial sarcoma-initiating cells ONCOGENE. 2016.07; 35 (30): 3932-3943. ( DOI )

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  12. Takanori Chiba, Erika Ishihara, Norio Miyamura, Rika Narumi, Mihoko Kajita, Yasuyuki Fujita, Akira Suzuki, Yoshihiro Ogawa, Hiroshi Nishina: MDCK cells expressing constitutively active Yes-associated protein (YAP) undergo apical extrusion depending on neighboring cell status. Sci Rep. 2016.06; 6 28383. ( PubMed , DOI )

  13. Shunta Nagashima, Junichi Maruyama, Shodai Kawano, Hiroaki Iwasa, Kentaro Nakagawa, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiroshi Nishina, Yutaka Hata: Validation of chemical compound library screening for transcriptional co-activator with PDZ-binding motif inhibitors using GFP-fused transcriptional co-activator with PDZ-binding motif. Cancer Sci.. 2016.06; 107 (6): 791-802. ( PubMed , DOI )

  14. Tabu K, Muramatsu N, Mangani C, Wu M, Zhang R, Kimura T, Terashima K, Bizen N, Kimura R, Wang W, Murota Y, Kokubu Y, Nobuhisa I, Kagawa T, Kitabayashi I, Bradley M, and Taga T: A synthetic polymer scaffold reveals the self-maintenance strategies of rat glioma stem cells by organization of the advantageous niche. Stem Cells. 2016.05; 34 1151-1162. ( PubMed , DOI )

  15. Toshiyasu Goto, Junhei Matsuzawa, Shun-Ichiro Iemura, Tohru Natsume, Hiroshi Shibuya: WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway. FEBS Lett.. 2016.05; 590 (9): 1291-1303. ( PubMed , DOI )

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  1. 齋藤 清香, 信久 幾夫, Anani Maha, 原田 果歩, 高橋 聡美, 田賀 哲也: マウス胎生期成体型造血の場AGM領域の未分化血球系細胞塊におけるSox17-Notch1-Hes1経路による未分化性維持 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015.12; 88回・38回 [1P0983]. ( ichushi )

  2. 椨 康一, 村松 希美, 田賀 哲也: 人工ニッチポリマーの応用による鉄貯蔵/腫瘍随伴マクロファージの誘導を介するグリオーマ幹細胞の環境適応戦略の解明 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015.12; 88回・38回 [1P1039]. ( ichushi )

  3. Katsumori Segawa, Shigekazu Nagata: An Apoptotic 'Eat Me' Signal: Phosphatidylserine Exposure. Trends Cell Biol. 2015.11; 25 (11): 639-650. ( PubMed , DOI )

  4. Franco H Falcone, Marcos J C Alcocer, Yoshimi Okamoto-Uchida, Ryosuke Nakamura: Use of humanized rat basophilic leukemia reporter cell lines as a diagnostic tool for detection of allergen-specific IgE in allergic patients: time for a reappraisal? Curr Allergy Asthma Rep. 2015.11; 15 (11): 67. ( PubMed , DOI )

  5. Yu. R.: Miyamura, N.; Okamoto-Uchida, Y.; Arima, N.; Ishigami-Yuasa, M.; Kagechika, H.; Nishina, H.: A Modified Murine Embryonic Stem Cell Test for Evaluating the Teratogenic Effects of Drugs on Early Embryogenesis Plos ONE. 2015.11; 10 e0145286. ( DOI )

  6. Kiyomi Nigorikawa, Kaoru Hazeki, Junko Sasaki, Yumio Omori, Mikiko Miyake, Shin Morioka, Ying Guo, Takehiko Sasaki, Osamu Hazeki: Inositol Polyphosphate-4-Phosphatase Type I Negatively Regulates Phagocytosis via Dephosphorylation of Phagosomal PtdIns(3,4)P2. PLoS ONE. 2015.11; 10 (11): e0142091. ( PubMed , DOI )

  7. 王 文茜, 椨 康一, 国分 康博, 萩谷 祐一郎, 小倉 俊一郎, 田賀 哲也: C6グリオーマ幹細胞を移植したマウスに観察された異常脾臓造血とその特性解明 日本癌学会総会記事. 2015.10; 74回 E-1146. ( ichushi )

  8. Nahoko Kaniwa, Mayumi Ueta, Ryosuke Nakamura, Yoshimi Okamoto-Uchida, Emiko Sugiyama, Keiko Maekawa, Yukitoshi Takahashi, Hirokazu Furuya, Akiko Yagami, Setsuko Matsukura, Zenro Ikezawa, Kayoko Matsunaga, Chie Sotozono, Michiko Aihara, Shigeru Kinoshita, Yoshiro Saito: Drugs causing severe ocular surface involvements in Japanese patients with Stevens-Johnson syndrome/toxic epidermal necrolysis. Allergol Int. 2015.10; 64 (4): 379-381. ( PubMed , DOI )

  9. Nobuhisa Ikuo, Saito Kiyoka, Takahashi Satomi, Harada Kaho, Anani Maha, Taga Tetsuya: 造血と免疫系微小環境　Sox17は、Notchシグナル伝達を介し、大動脈-性腺-中腎領域における大動脈内造血細胞クラスタの幹細胞集団を維持する(Hematopoiesis and microenvironments for immune system　Sox17 maintains the stem cell population of intra-aortic hematopoietic cell clusters in the aorta-gonad-mesonephros region through Notch signaling) 日本免疫学会総会・学術集会記録. 2015.10; 44 (Proceedings): 147. ( ichushi )

  10. Kaniwa Nahoko, Ueta Mayumi, Nakamura Ryosuke, Okamoto-Uchida Yoshimi, Sugiyama Emiko, Maekawa Keiko, Takahashi Yukitoshi, Furuya Hirokazu, Yagami Akiko, Matsukura Setsuko, Ikezawa Zenro, Matsunaga Kayoko, Sotozono Chie, Aihara Michiko, Kinoshita Shigeru, Saito Yoshiro: Stevens-Johnson症候群/中毒性表皮壊死症の日本人患者において重症眼表面疾患を引き起こした薬物(Drugs causing severe ocular surface involvements in Japanese patients with Stevens-Johnson syndrome/toxic epidermal necrolysis) Allergology International. 2015.10; 64 (4): 379-381. ( ichushi )

  11. Saito Kiyoka, Nobuhisa Ikuo, Anani Maha, Harada Kaho, Takahashi Satomi, Taga Tetsuya: MAINTENANCE OF HEMATOPOIETIC STEM AND PROGENITOR CELL PHENOTYPE OF INTRA-AORTIC CELL CLUSTERS IN THE AGM REGION THROUGH THE SOX17-NOTCH1-HES1 AXIS EXPERIMENTAL HEMATOLOGY. 2015.09; 43 (9): S92.

  12. Nobuhisa Ikuo, Osawa Mitsujiro, Uemura Mami, Harada Kaho, Anani Maha, Saito Kiyoka, Takagi Haruna, Takahashi Satomi, Kanai-Azuma Masami, Kanai Yoshiakira, Iwama Atsushi, Taga Tetsuya: SOX17 IS CRITICAL FOR THE MAINTENANCE OF STEM CELL PHENOTYPE OF INTRA-AORTIC HEMATOPOIETIC CLUSTERS OF CELLS IN THE AORTA-GONAD-MESONEPHROS REGION EXPERIMENTAL HEMATOLOGY. 2015.09; 43 (9): S85.

  13. PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2 2015.08; 17 (8): 1024-U360. ( PubMed , DOI )

  14. Chen Li Chew, Andrea Lunardi, Federico Gulluni, Daniel T Ruan, Ming Chen, Leonardo Salmena, Michiya Nishino, Antonella Papa, Christopher Ng, Jacqueline Fung, John G Clohessy, Junko Sasaki, Takehiko Sasaki, Roderick T Bronson, Emilio Hirsch, Pier Paolo Pandolfi: In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes. Cancer Discov. 2015.07; 5 (7): 740-751. ( PubMed , DOI )

  15. Satoshi Kofuji, Hirotaka Kimura, Hiroki Nakanishi, Hiroshi Nanjo, Shunsuke Takasuga, Hui Liu, Satoshi Eguchi, Ryotaro Nakamura, Reietsu Itoh, Noriko Ueno, Ken Asanuma, Mingguo Huang, Atsushi Koizumi, Tomonori Habuchi, Masakazu Yamazaki, Akira Suzuki, Junko Sasaki, Takehiko Sasaki: INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor. Cancer Discov. 2015.07; 5 (7): 730-739. ( PubMed , DOI )

  16. PCTK1 Regulates Integrin-Dependent Spindle Orientation via Protein Kinase A Regulatory Subunit KAP0 and Myosin X 2015.04; 35 (7): 1197-1208. ( PubMed , DOI )

  17. Sean Porazinski, Huijia Wang, Yoichi Asaoka, Martin Behrndt, Tatsuo Miyamoto, Hitoshi Morita, Shoji Hata, Takashi Sasaki, S.F. Gabby Krens, Yumi Osada, Satoshi Asaka, Akihiro Momoi, Sarah Linton, Joel B. Miesfeld, Brian A. Link, Takeshi Senga, Atahualpa Castillo-Morales, Araxi O. Urrutia, Nobuyoshi Shimizu, Hideaki Nagase, Shinya Matsuura, Stefan Bagby, Hisato Kondoh, Hiroshi Nishina, Carl-Philipp Heisenberg and Makoto Furutani-Seiki: YAP is essential for tissue tension to ensure vertebrate 3D body shape Nature. 2015.04;

  18. Laura R H Ip, George Poulogiannis, Felipe Cia Viciano, Junko Sasaki, Satoshi Kofuji, Victoria J Spanswick, Daniel Hochhauser, John A Hartley, Takehiko Sasaki, Christina A Gewinner: Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment. Oncotarget. 2015.04; 6 (12): 10548-10562. ( PubMed , DOI )

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  1. Pregnenolone Functions in Centriole Cohesion during Mitosis 2014.12; 21 (12): 1707-1721. ( PubMed , DOI )

  2. Y. Fujioka, M. Tsuda, A. Nanbo, T. Hattori, J. Sasaki, T. Sasaki, T. Miyazaki, Y. Ohba: Calcium signaling mediated influenza virus entry into host cells. MOLECULAR BIOLOGY OF THE CELL. 2014.12; 25

  3. Y. Fujioka, M. Tsuda, A. Nanbo, T. Hattori, J. Sasaki, T. Sasaki, T. Miyazaki, Y. Ohba: Calcium signaling mediated influenza virus entry into host cells. MOLECULAR BIOLOGY OF THE CELL. 2014.12; 25

  4. Hiroyuki Takatsu, Gaku Tanaka, Katsumori Segawa, Jun Suzuki, Shigekazu Nagata, Kazuhisa Nakayama, Hye-Won Shin: Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane. J Biol Chem. 2014.11; 289 (48): 33543-33556. ( PubMed , DOI )

  5. Inagaki Tetsunori, Kato Kiyoko, Kusunoki Soshi, Tabu Koichi, Okabe Hitomi, Yamada Izumi, Taga Tetsuya, Matsumoto Akemi, Takezawa Toshiaki, Makino Shintaro, Takeda Satoru: IDENTIFICATION AND CHARACTERIZATION OF HTR-8/SVNEO SP CELLS. PLACENTA. 2014.10; 35 (10): A6.

  6. Nobuyuki Shimizu, Shizuka Ishitani, Atsushi Sato, Hiroshi Shibuya, Tohru Ishitani: Hipk2 and PP1c cooperate to maintain Dvl protein levels required for Wnt signal transduction. Cell Rep. 2014.09; 8 (5): 1391-1404. ( PubMed , DOI )

  7. 椨 康一, 國分 康博, 田賀 哲也: 癌幹細胞ニッチの自己構築における自発的オートスキジスの関与の検討(Autoschizic cancer cell death and its implications to cancer stem cell niche) 日本癌学会総会記事. 2014.09; 73回 P-1167. ( ichushi )

  8. 國分 康博, 椨 康一, 王 文茜, バグダディ・ムハンマド , 地主 将久, 田賀 哲也: C6グリオーマ癌幹細胞由来GM-CSFはCD11c high CD204(+)腫瘍促進性マクロファージを誘導する(C6 glioma stem cell-derived GM-CSF induces CD11chighCD204(+) protumoral macrophages) 日本癌学会総会記事. 2014.09; 73回 P-1176. ( ichushi )

  9. 王 文茜, 椨 康一, 萩谷 祐一郎, 小倉 俊一郎, 田賀 哲也: 非癌幹細胞由来ヘムの赤血球分化へ与える影響(Roles of cancer-derived heme in erythropoiesis: implications for erythroid niche for cancer stem cells) 日本癌学会総会記事. 2014.09; 73回 P-1168. ( ichushi )

  10. Anani Maha, Nobuhisa Ikuo, Osawa Mitsujiro, Iwama Atsushi, Harada Kaho, Saito Kiyoka, Taga Tetsuya: 骨髄に限定された分化能を持つ調節因子候補としてのSox17(Sox17 as a candidate regulator of myeloid restricted differentiation potential) Development, Growth & Differentiation. 2014.08; 56 (6): 469-479. ( ichushi )

  11. Anani Maha, Nobuhisa Ikuo, Osawa Mitsujiro, Iwama Atsushi, Harada Kaho, Saito Kiyoka, Taga Tetsuya: Sox17 as a candidate regulator of myeloid restricted differentiation potential. Dev Growth Differ. 2014.08; 56 (6): 469-479. ( PubMed , DOI )

  12. Tomonori Ayukawa, Masakazu Akiyama, Jennifer L Mummery-Widmer, Thomas Stoeger, Junko Sasaki, Juergen A Knoblich, Haruki Senoo, Takehiko Sasaki, Masakazu Yamazaki: Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in Drosophila. Cell Rep. 2014.07; 8 (2): 610-621. ( PubMed , DOI )

  13. Katsumori Segawa, Sachiko Kurata, Yuichi Yanagihashi, Thijn R Brummelkamp, Fumihiko Matsuda, Shigekazu Nagata: Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure. Science. 2014.06; 344 (6188): 1164-1168. ( PubMed , DOI )

  14. Satoshi Toda, Katsumori Segawa, Shigekazu Nagata: MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands. Blood. 2014.06; 123 (25): 3963-3971. ( PubMed , DOI )

  15. Shuji Terai, Taro Takami, Naoki Yamamoto, Koichi Fujisawa, Tsuyoshi Ishikawa, Yohei Urata, Haruko Tanimoto, Takuya Iwamoto, Yuko Mizunaga, Takashi Matsuda, Takashi Oono, Miho Marumoto, Guzel Burganova, Luiz Fernando Quintanilha, Isao Hidaka, Yoshio Marumoto, Issei Saeki, Koichi Uchida, Takahiro Yamasaki, Kenji Tani, Yasuho Taura, Yasuhiko Fujii, Hiroshi Nishina, Kiwamu Okita, Isao Sakaida: Status and prospects of liver cirrhosis treatment by using bone marrow-derived cells and mesenchymal cells. Tissue Eng Part B Rev. 2014.06; 20 (3): 206-210. ( PubMed , DOI )

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  17. Nobuhisa Ikuo, Osawa Mitsujiro, Uemura Mami, Kishikawa Yoko, Anani Maha, Harada Kaho, Takagi Haruna, Saito Kiyoka, Kanai-Azuma Masami, Kanai Yoshiakira, Iwama Atsushi, Taga Tetsuya: Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters. Mol Cell Biol. 2014.06; 34 (11): 1976-1990. ( PubMed , DOI )

  18. Khajuria A., Tabu K., Taga T.: Glioma stem cells exploit host astrocytes to enhance tumour migratory and invasive capacity BRITISH JOURNAL OF SURGERY. 2014.05; 101 36-37.

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  20. Chihiro Nishi, Satoshi Toda, Katsumori Segawa, Shigekazu Nagata: Tim4- and MerTK-mediated engulfment of apoptotic cells by mouse resident peritoneal macrophages. Mol Cell Biol. 2014.04; 34 (8): 1512-1520. ( PubMed , DOI )

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  1. Toshiyasu Goto, Atsushi Sato, Shungo Adachi, Shun-ichiro Iemura, Tohru Natsume, Hiroshi Shibuya: IQGAP1 protein regulates nuclear localization of β-catenin via importin-β5 protein in Wnt signaling. J. Biol. Chem.. 2013.12; 288 (51): 36351-36360. ( PubMed , DOI )

  2. Nobuhisa Ikuo, Osawa Mitsujiro, Harada Kaho, Anani Maha, Saito Kiyoka, Takagi Haruna, Iwama Atsushi, Taga Tetsuya, Uemura Mami, Kanai Yoshiaki, Kanai-Azuma Masami: Sox17形質導入細胞移植マウスの骨髄細胞を移植したレシピエントの分析(Analysis of recipients transplantated with the bone marrow cells of Sox17-transduced cells-transplanted mice) 日本免疫学会総会・学術集会記録. 2013.11; 42 (Proceedings): 70. ( ichushi )

  3. Yoichiro Fujioka, Masumi Tsuda, Asuka Nanbo, Tomoe Hattori, Junko Sasaki, Takehiko Sasaki, Tadaaki Miyazaki, Yusuke Ohba: A Ca(2+)-dependent signalling circuit regulates influenza A virus internalization and infection. Nat Commun. 2013.11; 4 2763. ( PubMed , DOI )

  4. 椨 康一, 村松 希美, 田賀 哲也: 人工ポリマーを用いたC6グリオーマ幹細胞ニッチの同定(Polymer-based identification of cancer stem cell niche for C6 glioma) 日本癌学会総会記事. 2013.10; 72回 141. ( ichushi )

  5. Yoichi Asaoka, Shuji Terai, Isao Sakaida, Hiroshi Nishina: The expanding role of fish models in understanding non-alcoholic fatty liver disease. Dis Model Mech. 2013.07; 6 (4): 905-914. ( PubMed , DOI )

  6. Menno J Oudhoff, Spencer A Freeman, Amber L Couzens, Frann Antignano, Ekaterina Kuznetsova, Paul H Min, Jeffrey P Northrop, Bernhard Lehnertz, Dalia Barsyte-Lovejoy, Masoud Vedadi, Cheryl H Arrowsmith, Hiroshi Nishina, Michael R Gold, Fabio M V Rossi, Anne-Claude Gingras, Colby Zaph: Control of the hippo pathway by Set7-dependent methylation of Yap. Dev. Cell. 2013.07; 26 (2): 188-194. ( PubMed , DOI )

  7. Masahiro Shimizu, Toshiyasu Goto, Atsushi Sato, Hiroshi Shibuya: WNK4 is an essential effector of anterior formation in FGF signaling. Genes Cells. 2013.06; 18 (6): 442-449. ( PubMed , DOI )

  8. Norie Arima, Yoshimi Uchida, Ruoxing Yu, Koh Nakayama, Hiroshi Nishina: Acetylcholine receptors regulate gene expression that is essential for primitive streak formation in murine embryoid bodies. Biochem. Biophys. Res. Commun.. 2013.06; 435 (3): 447-453. ( PubMed , DOI )

  9. Kusunoki Soshi, Kato Kiyoko, Tabu Kouichi, Inagaki Tetsunori, Okabe Hitomi, Kaneda Hiroshi, Suga Shin, Terao Yasuhisa, Taga Tetsuya, Takeda Satoru: The inhibitory effect of salinomycin on the proliferation, migration and invasion of human endometrial cancer stem-like cells. Gynecol Oncol. 2013.06; 129 (3): 598-605. ( PubMed , DOI )

  10. Yasuo Horie, Shunsuke Takasuga, Hirosato Mashima, Takehiko Sasaki, Hirohide Ohnishi: Epithelial Mesenchymal Transition in Intestinal Epithelia Based on the Loss of Pipkiii Kinase Activity Induces Intestinal Fibrosis in Enterocyte-Specific Pipk III Deficient Mice GASTROENTEROLOGY. 2013.05; 144 (5): S669.

  11. Hideaki Morishita, Satoshi Eguchi, Hirotaka Kimura, Junko Sasaki, Yuriko Sakamaki, Michael L Robinson, Takehiko Sasaki, Noboru Mizushima: Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation. J. Biol. Chem.. 2013.04; 288 (16): 11436-11447. ( PubMed , DOI )

  12. Goto T., Michiue T., Ito Y., Asashima M.: Characterization of CXC-type chemokine molecules in early Xenopus laevis development. Int. J. Dev. Biol.. 2013.03; 57 41-47. ( PubMed , DOI )

  13. Asanuma Ken, Takasuga Shunsuke, Sasaki Junko, Sasaki Takehiko: PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE IS AN ESSENTIAL REGULATOR OF LYSOSOME MORPHOLOGY 秋田医学. 2013.03; 39 (3): 129-137.

  14. Chida Shinsuke, Itoh Reietsu, Kofuji Satoshi, Eguchi Satoshi, Takasuga Shunsuke, Sasaki Junko, Sasaki Takehiko: SHIP1 DELETION ENHANCES ROS PRODUCTION AND DECREASES SURVIVAL OF THE S. AUREUS INFECTED MICE 秋田医学. 2013.03; 39 (3): 95-101.

  15. Uemura Mami, Ozawa Aisa, Nagata Takumi, Kurasawa Kaoruko, Tsunekawa Naoki, Nobuhisa Ikuo, Taga Tetsuya, Hara Kenshiro, Kudo Akihiko, Kawakami Hayato, Saijoh Yukio, Kurohmaru Masamichi, Kanai-Azuma Masami, Kanai Yoshiakira: Sox17 haploinsufficiency results in perinatal biliary atresia and hepatitis in C57BL/6 background mice. Development. 2013.02; 140 (3): 639-648. ( PubMed , DOI )

  16. Shunsuke Takasuga, Yasuo Horie, Junko Sasaki, Ge-Hong Sun-Wada, Nobuyuki Kawamura, Ryota Iizuka, Katsunori Mizuno, Satoshi Eguchi, Satoshi Kofuji, Hirotaka Kimura, Masakazu Yamazaki, Chihoko Horie, Eri Odanaga, Yoshiko Sato, Shinsuke Chida, Kenji Kontani, Akihiro Harada, Toshiaki Katada, Akira Suzuki, Yoh Wada, Hirohide Ohnishi, Takehiko Sasaki: Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc. Natl. Acad. Sci. U.S.A.. 2013.01; 110 (5): 1726-1731. ( PubMed , DOI )

  17. Essential role of class II phosphatidylinositol-3-kinase-C2α in sphingosine 1-phosphate receptor-1-mediated signaling and migration in endothelial cells. The Journal of biological chemistry. 2013.01; 288 (4): 2325-2339. ( PubMed , DOI )

  18. Atsushi Sato, Hiroshi Shibuya: WNK signaling is involved in neural development via Lhx8/Awh expression. PLoS ONE. 2013; 8 (1): e55301. ( PubMed , DOI )

  19. Toshiyasu Goto, Atsushi Sato, Masahiro Shimizu, Shungo Adachi, Kiyotoshi Satoh, Shun-ichiro Iemura, Tohru Natsume, Hiroshi Shibuya: IQGAP1 functions as a modulator of dishevelled nuclear localization in Wnt signaling. PLoS ONE. 2013; 8 (4): e60865. ( PubMed , DOI )

  20. Tabu Kouichi, Bizen Norihisa, Taga Tetsuya, Tanaka Shinya: Gene Regulation of Prominin-1 (CD133) in Normal and Cancerous Tissues. Adv Exp Med Biol. 2013; 777 73-85. ( PubMed , DOI )

  1. Miki Nishio, Koichi Hamada, Kohichi Kawahara, Masato Sasaki, Fumihito Noguchi, Shuhei Chiba, Kensaku Mizuno, Satoshi O Suzuki, Youyi Dong, Masaaki Tokuda, Takumi Morikawa, Hiroki Hikasa, Jonathan Eggenschwiler, Norikazu Yabuta, Hiroshi Nojima, Kentaro Nakagawa, Yutaka Hata, Hiroshi Nishina, Koshi Mimori, Masaki Mori, Takehiko Sasaki, Tak W Mak, Toru Nakano, Satoshi Itami, Akira Suzuki: Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J. Clin. Invest.. 2012.12; 122 (12): 4505-4518. ( PubMed , DOI )

  2. Hyeon-Cheol Lee, Takao Inoue, Junko Sasaki, Takuya Kubo, Shinji Matsuda, Yasuko Nakasaki, Mitsuharu Hattori, Fumiharu Tanaka, Osamu Udagawa, Nozomu Kono, Toshiki Itoh, Hideo Ogiso, Ryo Taguchi, Makoto Arita, Takehiko Sasaki, Hiroyuki Arai: LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice. Mol. Biol. Cell. 2012.12; 23 (24): 4689-4700. ( PubMed , DOI )

  3. Masahiro Shinohara, Masaki Nakamura, Hironari Masuda, Jun Hirose, Yuho Kadono, Mitsuyasu Iwasawa, Yuuichi Nagase, Kohjiro Ueki, Takashi Kadowaki, Takehiko Sasaki, Shigeaki Kato, Hiroaki Nakamura, Sakae Tanaka, Hiroshi Takayanagi: Class IA Phosphatidylinositol 3-Kinase Regulates Osteoclastic Bone Resorption Through Protein Kinase B-Mediated Vesicle Transport JOURNAL OF BONE AND MINERAL RESEARCH. 2012.12; 27 (12): 2464-2475. ( PubMed , DOI )

  4. Nobuhisa Ikuo, Osawa Mitsujiro, Harada Kaho, Takagi Haruna, Iwama Atsushi, Taga Tetsuya: 造血系の発生とリンパ血液系へのコミットメント　大動脈-性腺-中腎領域からの造血細胞クラスターはSox17の過剰発現により長期再構築能を示す(Hematopoietic cell clusters from the aorta-gonad-mesonephros region exhibited long-term repopulating ability by overexpression of Sox17) 日本免疫学会総会・学術集会記録. 2012.11; 41 126. ( ichushi )

  5. G Gregory Neely, Shuan Rao, Michael Costigan, Norbert Mair, Ildiko Racz, Giedre Milinkeviciute, Arabella Meixner, Swetha Nayanala, Robert S Griffin, Inna Belfer, Feng Dai, Shad Smith, Luda Diatchenko, Stefano Marengo, Bernhard J Haubner, Maria Novatchkova, Dustin Gibson, William Maixner, J Andrew Pospisilik, Emilio Hirsch, Ian Q Whishaw, Andreas Zimmer, Vaijayanti Gupta, Junko Sasaki, Yasunori Kanaho, Takehiko Sasaki, Michaela Kress, Clifford J Woolf, Josef M Penninger: Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. PLoS Genet.. 2012.11; 8 (12): e1003071. ( PubMed , DOI )

  6. Kagawa T., Kinoshita S., Phillips G., Tomiyoshi S., Bizen N., Shimizu T., Taga T.: Role of glycogen synthase kinase 3 beta in neuronal migration during corticogenesis JOURNAL OF NEUROCHEMISTRY. 2012.10; 123 39.

  7. Kazuaki Yoshioka, Kotaro Yoshida, Hong Cui, Tomohiko Wakayama, Noriko Takuwa, Yasuo Okamoto, Wa Du, Xun Qi, Ken Asanuma, Kazushi Sugihara, Sho Aki, Hidekazu Miyazawa, Kuntal Biswas, Chisa Nagakura, Masaya Ueno, Shoichi Iseki, Robert J Schwartz, Hiroshi Okamoto, Takehiko Sasaki, Osamu Matsui, Masahide Asano, Ralf H Adams, Nobuyuki Takakura, Yoh Takuwa: Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function. Nat. Med.. 2012.10; 18 (10): 1560-1569. ( PubMed , DOI )

  8. Masanori Miyanishi, Katsumori Segawa, Shigekazu Nagata: Synergistic effect of Tim4 and MFG-E8 null mutations on the development of autoimmunity. Int Immunol. 2012.09; 24 (9): 551-559. ( PubMed , DOI )

  9. Ryosuke Nakamura, Ayano Ishiwatari, Masakazu Higuchi, Yoshimi Uchida, Rika Nakamura, Hiroshi Kawakami, Atsuo Urisu, Reiko Teshima: Evaluation of the luciferase assay-based in vitro elicitation test for serum IgE. Allergol Int. 2012.09; 61 (3): 431-437. ( PubMed , DOI )

  10. Nakamura Ryosuke, Ishiwatari Ayano, Higuchi Masakazu, Uchida Yoshimi, Nakamura Rika, Kawakami Hiroshi, Urisu Atsuo, Teshima Reiko: ルシフェラーゼアッセイに基づいた血清中IgEのin vitro惹起試験の評価(Evaluation of the Luciferase Assay-Based In Vitro Elicitation Test for Serum IgE) Allergology International. 2012.09; 61 (3): 431-437. ( ichushi )

  11. Hiroshi Nishina: hDlk-1: a cell surface marker common to normal hepatic stem/progenitor cells and carcinomas. J. Biochem.. 2012.08; 152 (2): 121-123. ( PubMed , DOI )

  12. 椨 康一, 田賀 哲也: 人工ニッチを用いた腫瘍幹細胞の不均一性の解析(Functional heterogeneity within a tumor stem cell population identified by the synthetic polymer niche) 日本癌学会総会記事. 2012.08; 71回 316. ( ichushi )

  13. 村松 希美, 椨 康一, 田賀 哲也: C6グリオーマSP細胞はマウス骨髄由来単球系細胞のマクロファージへの分化を誘導する(C6 glioma side population cells induce differentiation of bone marrow-derived monocyte lineage cells into macrophages) 日本癌学会総会記事. 2012.08; 71回 289. ( ichushi )

  14. Shoji Hata, Jun Hirayama, Hiroaki Kajiho, Kentaro Nakagawa, Yutaka Hata, Toshiaki Katada, Makoto Furutani-Seiki, Hiroshi Nishina: A novel acetylation cycle of transcription co-activator Yes-associated protein that is downstream of Hippo pathway is triggered in response to SN2 alkylating agents. J. Biol. Chem.. 2012.06; 287 (26): 22089-22098. ( PubMed , DOI )

  15. Tatsuki Kurokawa, Shunsuke Takasuga, Souhei Sakata, Shinji Yamaguchi, Shigeo Horie, Koichi J Homma, Takehiko Sasaki, Yasushi Okamura: 3' Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] by voltage-sensing phosphatase (VSP). Proc. Natl. Acad. Sci. U.S.A.. 2012.06; 109 (25): 10089-10094. ( PubMed , DOI )

  16. Kimura T, Wang L, Tabu K, Nishihara H, Mashita Y, Kikuchi N, Tanino M, Hiraga H, Tanaka S: CD133 negatively regulates tumorigenicity via AKT pathway in synovial sarcoma. Cancer investigation. 2012.06; 30 (5): 390-7. ( PubMed , DOI )

  17. Ken Okada, Akihide Kamiya, Keiichi Ito, Ayaka Yanagida, Hidenori Ito, Hiroki Kondou, Hiroshi Nishina, Hiromitsu Nakauchi: Prospective isolation and characterization of bipotent progenitor cells in early mouse liver development. Stem Cells Dev.. 2012.05; 21 (7): 1124-1133. ( PubMed , DOI )

  18. Toshiyuki Oishi, Shuji Terai, Shinya Kuwashiro, Koichi Fujisawa, Toshihiko Matsumoto, Hiroshi Nishina, Isao Sakaida: Ezetimibe reduces fatty acid quantity in liver and decreased inflammatory cell infiltration and improved NASH in medaka model. Biochem. Biophys. Res. Commun.. 2012.05; 422 (1): 22-27. ( PubMed , DOI )

  19. Yasuo Horie, Shunsuke Takasuga, Takehiko Sasaki, Hirohide Ohnishi: Contribution of Intestinal Bacteria and Epithelial Mesenchymal Transition to Intestinal Inflammation and Fibrosis in Enterocyte-Specific Pipk III Deficient Mice GASTROENTEROLOGY. 2012.05; 142 (5): S689.

  20. Tanino M, Kohsaka S, Kimura T, Tabu K, Nishihara H, Sawa H, Kawami H, Kamada H, Shimizu M, Tanaka S: A case of clear cell variant of solid-pseudopapillary tumor of the pancreas in an adult male patient. Annals of diagnostic pathology. 2012.04; 16 (2): 134-40. ( PubMed , DOI )

  21. Nobuhisa Ikuo, Yamasaki Shoutarou, Ramadan Ahmed, Taga Tetsuya: CD45(low)c-Kit(high) cells have hematopoietic properties in the mouse aorta-gonad-mesonephros region. Exp Cell Res. 2012.04; 318 (6): 705-715. ( PubMed , DOI )

  22. Akira Suzuki, Ryunosuke Kogo, Kohichi Kawahara, Masato Sasaki, Miki Nishio, Tomohiko Maehama, Takehiko Sasaki, Koshi Mimori, Masaki Mori: A new PICTure of nucleolar stress CANCER SCIENCE. 2012.04; 103 (4): 632-637. ( PubMed , DOI )

  23. Takuya Iwamoto, Shuji Terai, Yuko Mizunaga, Naoki Yamamoto, Kaoru Omori, Koichi Uchida, Takahiro Yamasaki, Yasuhiko Fujii, Hiroshi Nishina, Isao Sakaida: Splenectomy enhances the anti-fibrotic effect of bone marrow cell infusion and improves liver function in cirrhotic mice and patients. J. Gastroenterol.. 2012.03; 47 (3): 300-312. ( PubMed , DOI )

  24. Yoshimi Uchida, Tomomi Osaki, Tokiwa Yamasaki, Tadanori Shimomura, Shoji Hata, Kazumasa Horikawa, Shigenobu Shibata, Takeshi Todo, Jun Hirayama, Hiroshi Nishina: Involvement of stress kinase mitogen-activated protein kinase kinase 7 in regulation of mammalian circadian clock. J. Biol. Chem.. 2012.03; 287 (11): 8318-8326. ( PubMed , DOI )

  25. Rieko Imae, Takao Inoue, Yasuko Nakasaki, Yasunori Uchida, Yohsuke Ohba, Nozomu Kono, Hiroki Nakanishi, Takehiko Sasaki, Shohei Mitani, Hiroyuki Arai: LYCAT, a homologue of C. elegans acl-8, acl-9, and acl-10, determines the fatty acid composition of phosphatidylinositol in mice JOURNAL OF LIPID RESEARCH. 2012.03; 53 (3): 335-347. ( PubMed , DOI )

  26. Keiko Danzaki, Yutaka Matsui, Masahiro Ikesue, Daichi Ohta, Koyu Ito, Masashi Kanayama, Daisuke Kurotaki, Junko Morimoto, Yoichiro Iwakura, Hideo Yagita, Hiroyuki Tsutsui, Toshimitsu Uede: Interleukin-17A deficiency accelerates unstable atherosclerotic plaque formation in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol.. 2012.02; 32 (2): 273-280. ( PubMed , DOI )

  27. ABL1 regulates spindle orientation in adherent cells and mammalian skin 2012.01; 3 626. ( PubMed , DOI )

  28. Tokiwa Yamasaki, Hiroshi Kawasaki, Hiroshi Nishina: Diverse Roles of JNK and MKK Pathways in the Brain. J Signal Transduct. 2012; 2012 459265. ( PubMed , DOI )

  29. Yuko Mizunaga, Shuji Terai, Naoki Yamamoto, Koichi Uchida, Takahiro Yamasaki, Hiroshi Nishina, Yusuke Fujita, Koh Shinoda, Yoshihiko Hamamoto, Isao Sakaida: Granulocyte colony-stimulating factor and interleukin-1β are important cytokines in repair of the cirrhotic liver after bone marrow cell infusion: comparison of humans and model mice. Cell Transplant. 2012; 21 (11): 2363-2375. ( PubMed , DOI )

  30. ABL1 Joins the Cadre of Spindle Orientation Machinery 2012; 37 (2): 81-87. ( PubMed , DOI )

  31. Nobuyuki Kawamura, Ge-Hong Sun-Wada, Minako Aoyama, Akihiro Harada, Shunsuke Takasuga, Takehiko Sasaki, Yoh Wada: Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos. Nat Commun. 2012; 3 1071. ( PubMed , DOI )

  32. Tadashi Yokoi, Yuko Seko, Tae Yokoi, Hatsune Makino, Shin Hatou, Masakazu Yamada, Tohru Kiyono, Akihiro Umezawa, Hiroshi Nishina, Noriyuki Azuma: Establishment of functioning human corneal endothelial cell line with high growth potential. PLoS ONE. 2012; 7 (1): e29677. ( PubMed , DOI )

  1. Hiroshi Yukiura, Kotaro Hama, Keita Nakanaga, Masayuki Tanaka, Yoichi Asaoka, Shinichi Okudaira, Naoaki Arima, Asuka Inoue, Takafumi Hashimoto, Hiroyuki Arai, Atsuo Kawahara, Hiroshi Nishina, Junken Aoki: Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish. J. Biol. Chem.. 2011.12; 286 (51): 43972-43983. ( PubMed , DOI )

  2. Goto T., Asashima M.: Chemokine ligand Xenopus CXCLC (XCXCLC) regulates cell movements during early morphogenesis. Dev. Growth Differ.. 2011.12; 53 971-981.. ( PubMed , DOI )

  3. Masashi Kanayama, Junko Morimoto, Yutaka Matsui, Masahiro Ikesue, Keiko Danzaki, Daisuke Kurotaki, Koyu Ito, Toshimichi Yoshida, Toshimitsu Uede: α9β1 integrin-mediated signaling serves as an intrinsic regulator of pathogenic Th17 cell generation. J. Immunol.. 2011.12; 187 (11): 5851-5864. ( PubMed , DOI )

  4. Yamasaki T, Kawasaki H, Arakawa S, Shimizu K, Shimizu S, Reiner O, Okano H, Nishina S, Azuma N, Penninger JM, Katada T, Nishina H: Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex. J Neurosci. 2011.11; 31 (46): 16872-16883. ( PubMed , DOI )

  5. Katsumori Segawa, Jun Suzuki, Shigekazu Nagata: Constitutive exposure of phosphatidylserine on viable cells. Proc Natl Acad Sci U S A. 2011.11; 108 (48): 19246-19251. ( PubMed , DOI )

  6. Nobuhisa Ikuo, Kishikawa Yuko, Anai Maha, Taga Tetsuya: 造血・免疫系形成　SoxFファミリータンパク質にはAGM領域における造血前駆細胞の未分化性を保持する役割がある(SoxF family proteins have roles in maintenance of immature phenotype of hematopoietic progenitors in the aorta-gonad-mesonephros region) 日本免疫学会総会・学術集会記録. 2011.11; 40 145. ( ichushi )

  7. Takuro Hisanaga, Shuji Terai, Takuya Iwamoto, Taro Takami, Naoki Yamamoto, Tomoaki Murata, Toshifumi Matsuyama, Hiroshi Nishina, Isao Sakaida: TNFR1-mediated signaling is important to induce the improvement of liver fibrosis by bone marrow cell infusion. Cell Tissue Res.. 2011.10; 346 (1): 79-88. ( PubMed , DOI )

  8. Yasuo Horie, Shunsuke Takasuga, Takehiko Sasaki, Hirohide Ohnishi: Functional Analysis of Phosphatidylinositol 3,5-Bisphosphate in Enterocytes Using Pipk III Deficient Mice DIGESTIVE DISEASES AND SCIENCES. 2011.10; 56 (10): 2769-2770.

  9. Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages. PloS one. 2011.10; 6 (10): ( PubMed , DOI )

  10. 椨 康一, 田賀 哲也: 合成ポリマーを用いたグリオーマ幹細胞制御(Control of glioma stem cells by the synthetic polymers) 日本癌学会総会記事. 2011.09; 70回 335. ( ichushi )

  11. 鹿川 哲史, 備前 典久, 柏木 太一, 信久 幾夫, 清水 健史, 田賀 哲也: New insight of functional interactions between neurons and astrocytes　中枢神経系グリア細胞の発生分化研究の現状と展望(New insight of functional interactions between neurons and astrocytes　Specification of glial cell types in the developing central nervous system) 神経化学. 2011.09; 50 (2-3): 150. ( ichushi )

  12. Yamasaki Shoutarou, Nobuhisa Ikuo, Ramadan Ahmed, Taga Tetsuya: CD45/c-Kit発現を考慮した造血活動をもつ卵黄細胞集団の同定(Identification of a yolk sac cell population with hematopoietic activity in view of CD45/c-Kit expression) Development, Growth & Differentiation. 2011.09; 53 (7): 870-877. ( ichushi )

  13. Yamasaki Shoutarou, Nobuhisa Ikuo, Ramadan Ahmed, Taga Tetsuya: Identification of a yolk sac cell population with hematopoietic activity in view of CD45/c-Kit expression. Dev Growth Differ. 2011.09; 53 (7): 870-877. ( PubMed , DOI )

  14. Yijun Bao, Kentaro Nakagawa, Zeyu Yang, Mitsunobu Ikeda, Kanchanamala Withanage, Mari Ishigami-Yuasa, Yukiko Okuno, Shoji Hata, Hiroshi Nishina, Yutaka Hata: A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription. J. Biochem.. 2011.08; 150 (2): 199-208. ( PubMed , DOI )

  15. Masato Sasaki, Kohichi Kawahara, Miki Nishio, Koshi Mimori, Ryunosuke Kogo, Koichi Hamada, Bunsho Itoh, Jia Wang, Yukako Komatsu, Yong Ryoul Yang, Hiroki Hikasa, Yasuo Horie, Takayuki Yamashita, Takehiko Kamijo, Yanping Zhang, Yan Zhu, Carol Prives, Toru Nakano, Tak Wah Mak, Takehiko Sasaki, Tomohiko Maehama, Masaki Mori, Akira Suzuki: Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat. Med.. 2011.07; 17 (8): 944-951. ( PubMed , DOI )

  16. Yasuo Horie, Shunsuke Takasuga, Takehiko Sasaki, Hirohide Ohnishi: Analysis of Intestinal Inflammation and Fibrosis Based on Impaired Production of Phosphatidylinositol 3,5-Bisphosphate on Enterocytes Using Type III Phosphatidylinositol Phosphate Kinase Deficient Mice GASTROENTEROLOGY. 2011.05; 140 (5): S85.

  17. Yutaka Matsui, Masahiro Ikesue, Keiko Danzaki, Junko Morimoto, Mami Sato, Shinya Tanaka, Tetsuhito Kojima, Hiroyuki Tsutsui, Toshimitsu Uede: Syndecan-4 prevents cardiac rupture and dysfunction after myocardial infarction. Circulation Research. 2011.05; 108 (11): 1328-1339. ( PubMed , DOI )

  18. Masahiro Ikesue, Yutaka Matsui, Daichi Ohta, Keiko Danzaki, Koyu Ito, Masashi Kanayama, Daisuke Kurotaki, Junko Morimoto, Tetsuhito Kojima, Hiroyuki Tsutsui, Toshimitsu Uede: Syndecan-4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenitor cell mobilization. Arteriosclerosis, Thrombosis, and Vascular Biology. 2011.05; 31 (5): 1066-1074. ( PubMed , DOI )

  19. Norio Miyamura, Takashi Nakamura, Naoko Goto-Inoue, Nobuhiro Zaima, Takahiro Hayasaka, Tokiwa Yamasaki, Shuji Terai, Isao Sakaida, Mitsutoshi Setou, Hiroshi Nishina: Imaging mass spectrometry reveals characteristic changes in triglyceride and phospholipid species in regenerating mouse liver. Biochem. Biophys. Res. Commun.. 2011.04; 408 (1): 120-125. ( PubMed , DOI )

  20. Shinya Takahashi, Kyoko Sakurai, Arisa Ebihara, Hiroaki Kajiho, Kota Saito, Kenji Kontani, Hiroshi Nishina, Toshiaki Katada: RhoA activation participates in rearrangement of processing bodies and release of nucleated AU-rich mRNAs. Nucleic Acids Res.. 2011.04; 39 (8): 3446-3457. ( PubMed , DOI )

  21. S Takahashi, A Ebihara, H Kajiho, K Kontani, H Nishina, T Katada: RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7. Cell Death Differ.. 2011.04; 18 (4): 645-655. ( PubMed , DOI )

  22. Shinya Kuwashiro, Shuji Terai, Toshiyuki Oishi, Koichi Fujisawa, Toshihiko Matsumoto, Hiroshi Nishina, Isao Sakaida: Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation. Cell Tissue Res.. 2011.04; 344 (1): 125-134. ( PubMed , DOI )

  23. Naoki Kobayashi, Kohjiro Ueki, Yukiko Okazaki, Aya Iwane, Naoto Kubota, Mitsuru Ohsugi, Motoharu Awazawa, Masatoshi Kobayashi, Takayoshi Sasako, Kazuma Kaneko, Miho Suzuki, Yoshitaka Nishikawa, Kazuo Hara, Kotaro Yoshimura, Isao Koshima, Susumu Goyama, Koji Murakami, Junko Sasaki, Ryozo Nagai, Mineo Kurokawa, Takehiko Sasaki, Takashi Kadowaki: Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance. Proc. Natl. Acad. Sci. U.S.A.. 2011.04; 108 (14): 5753-5758. ( PubMed , DOI )

  24. Taga Tetsuya, Yamaguchi Yuhei, Kokubu Yasuhiro, Hattori Satoko, Takao Keizo, Inazawa Johji, Miyakawa Tsuyoshi, Kagawa Tetsushi: 薬剤開発のための新しいトランスジェニックマウスモデル　神経発達障害の新しいマウスモデルの確立(New transgenic mouse models for drug development　Establishment of a new mouse model of neurodevelopmental disorder) Journal of Pharmacological Sciences. 2011.02; 115 (Suppl.1): 35P. ( ichushi )

  25. Hiroshi Hanafusa, Kouki Ishikawa, Shin Kedashiro, Tsukasa Saigo, Shun-Ichiro Iemura, Tohru Natsume, Masayuki Komada, Hiroshi Shibuya, Atsuki Nara, Kunihiro Matsumoto: Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor. Nat Commun. 2011.01; 2 158. ( PubMed , DOI )

  26. Yoichiro Fujioka, Masumi Tsuda, Tomoe Hattori, Junko Sasaki, Takehiko Sasaki, Tadaaki Miyazaki, Yusuke Ohba: The Ras-PI3K signaling pathway is involved in clathrin-independent endocytosis and the internalization of influenza viruses. PLoS ONE. 2011.01; 6 (1): e16324. ( PubMed , DOI )

  27. Nobukatsu Kinoshita, Yasuo Horie, Shigetoshi Ohshima, Yohei Hirai, Takahiro Dohmen, Mario Jin, Tamotsu Matsuhashi, Junko Sasaki, Takehiko Sasaki, Masahiro Iizuka, Hirohide Ohnishi: Epimorphin protects hepatocytes from oxidative stress by inhibiting mitochondrial injury. J. Gastroenterol. Hepatol.. 2011.01; 26 (1): 201-206. ( PubMed , DOI )

  28. Taga Tetsuya, Yamaguchi Yuhei, Kokubu Yasuhiro, Hattori Satoko, Takao Keizo, Inazawa Johji, Miyakawa Tsuyoshi, Kagawa Tetsushi: Establishment of a new mouse model of neurodevelopmental disorder JOURNAL OF PHARMACOLOGICAL SCIENCES. 2011; 115 35P.

  29. Tomomi Osaki, Yoshimi Uchida, Jun Hirayama, Hiroshi Nishina: Diphenyleneiodonium chloride, an inhibitor of reduced nicotinamide adenine dinucleotide phosphate oxidase, suppresses light-dependent induction of clock and DNA repair genes in zebrafish. Biol. Pharm. Bull.. 2011; 34 (8): 1343-1347. ( PubMed )

  30. Yoshimi Uchida, Tadanori Shimomura, Jun Hirayama & Hiroshi Nishina: Light, Reactive Oxygen Species, and Magnetic Fields Activating ERK/MAPK Signaling Pathway in Cultured Zebrafish Cells Applyed Magnetic Resonance . 2011; 42 69-77.

  1. 信久 幾夫, 岸川 陽子, 上村 麻実, Anani Maha, Gomaa Ahmed, 金井 正美, 金井 克晃, 田賀 哲也: 大動脈-生殖隆起-中腎領域由来の造血前駆細胞におけるSox-17の働きが未熟表現型を維持する(Role of Sox-17 in hamatopoietic progenitors from the aorta-gonad-mesonephros region maintains immature phenotype) 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2010.12; 83回・33回 3P-0895. ( ichushi )

  2. 田賀 哲也: 発生と分化におけるエピジェネティック制御　細胞外の合図と細胞固有のプログラムの相互作用が脳発生を制御する(Epigenetic Regulation in Development and Differentiation　Cross-interactions among cell-external cues and cell-intrinsic programs controlling brain development) 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2010.12; 83回・33回 1S12-1. ( ichushi )

  3. 備前 典久, 井上 俊洋, 清水 健史, 鹿川 哲史, 田賀 哲也: 神経幹/前駆細胞における細胞周期調節因子cyclin D1は細胞周期非依存的にアストロサイト分化を阻害する(Cyclin D1 inhibits astrocyte differentiation from neural stem/progenitor cells in a manner independent of cell cycle progression) 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2010.12; 83回・33回 3P-0876. ( ichushi )

  4. Jinzhan Wu, Junko Kubota, Jun Hirayama, Yoko Nagai, Sachiko Nishina, Tadashi Yokoi, Yoichi Asaoka, Jungwon Seo, Nao Shimizu, Hiroaki Kajiho, Takashi Watanabe, Noriyuki Azuma, Toshiaki Katada, Hiroshi Nishina: p38 Mitogen-activated protein kinase controls a switch between cardiomyocyte and neuronal commitment of murine embryonic stem cells by activating myocyte enhancer factor 2C-dependent bone morphogenetic protein 2 transcription. Stem Cells Dev.. 2010.11; 19 (11): 1723-1734. ( PubMed , DOI )

  5. Bizen Norihisa, Shimizu Takeshi, Inoue Toshihiro, Kagawa Tetsushi, Taga Tetsuya: Cross-talk between growth and differentiation pathways in cell fate determination in the developing brain DIFFERENTIATION. 2010.11; 80 S8. ( DOI )

  6. Revolving movement of a dynamic cluster of actin filaments during mitosis 2010.11; 191 (3): 453-462. ( PubMed , DOI )

  7. Toshiyasu Goto, Akimasa Fukui, Hiroshi Shibuya, Ray Keller, Makoto Asashima: Xenopus furry contributes to release of microRNA gene silencing. Proc. Natl. Acad. Sci. U.S.A.. 2010.11; 107 (45): 19344-19349. ( PubMed , DOI )

  8. Yoichi Asaoka, Hiroshi Nishina: Diverse physiological functions of MKK4 and MKK7 during early embryogenesis. J. Biochem.. 2010.10; 148 (4): 393-401. ( PubMed , DOI )

  9. Ogawa Y., Nonaka Y., Goto T., Ohnishi E., Hiramatsu T., Kii I., Yoshida M., Ikura T., Onogi H., Shibuya H., Hosoya T., Ito N., Hagiwara M.: Development of a novel selective inhibitor of the Downsyndrome-related kinase Dyrk1A. Nat. Commun.. 2010.10; ( PubMed , DOI )

  10. Ryosuke Nakamura, Y Uchida, M Higuchi, R Nakamura, I Tsuge, A Urisu, R Teshima: A convenient and sensitive allergy test: IgE crosslinking-induced luciferase expression in cultured mast cells. Allergy. 2010.10; 65 (10): 1266-1273. ( PubMed , DOI )

  11. Yoshinaga Yutaka, Kagawa Tetsushi, Shimizu Takeshi, Inoue Toshihiro, Takada Shinji, Kuratsu Jun-ichi, Taga Tetsuya: Wnt3a promotes hippocampal neurogenesis by shortening cell cycle duration of neural progenitor cells. Cell Mol Neurobiol. 2010.10; 30 (7): 1049-1058. ( PubMed , DOI )

  12. Ryuichi Mashima, Kazuho Honda, Yi Yang, Yohei Morita, Akane Inoue, Sumimasa Arimura, Hiroshi Nishina, Hideo Ema, Hiromitsu Nakauchi, Brian Seed, Hideaki Oda, Yuji Yamanashi: Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma. Lab. Invest.. 2010.09; 90 (9): 1357-1364. ( PubMed , DOI )

  13. Ramadan Ahmed, Nobuhisa Ikuo, Yamasaki Shoutarou, Nakagata Naomi, Taga Tetsuya: Cells with hematopoietic activity in the mouse placenta reside in side population. Genes Cells. 2010.09; 15 (9): 983-994. ( PubMed , DOI )

  14. Laura A Volpicelli-Daley, Louise Lucast, Liang-Wei Gong, Lijuan Liu, Junko Sasaki, Takehiko Sasaki, Charles S Abrams, Yasunori Kanaho, Pietro De Camilli: Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain. J. Biol. Chem.. 2010.09; 285 (37): 28708-28714. ( PubMed , DOI )

  15. 鹿川 哲史, 清水 健史, 荒木 喜美, 竹田 直樹, 中潟 直巳, 信久 幾夫, 田賀 哲也: 中枢神経系グリア亜集団細胞系譜のGFAP/Creレポーターマウスを用いた解析(Analysis of glial cell sub-lineages in the developing central nervous system using GFAP/Cre-reporter mouse system) 神経化学. 2010.08; 49 (2-3): 617. ( ichushi )

  16. Takeshi Maruyama, Hisae Kadowaki, Noriaki Okamoto, Atsushi Nagai, Isao Naguro, Atsushi Matsuzawa, Hiroshi Shibuya, Keiji Tanaka, Shigeo Murata, Kohsuke Takeda, Hideki Nishitoh, Hidenori Ichijo: CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response. EMBO J.. 2010.08; 29 (15): 2501-2514. ( PubMed , DOI )

  17. 椨 康一, 田賀 哲也: C6グリオーマ細胞株においてMPはSPの維持に寄与する(Main population helps side population in C6 glioma cell line) 日本癌学会総会記事. 2010.08; 69回 232. ( ichushi )

  18. 備前 典久, 井上 俊洋, 清水 健史, 鹿川 哲史, 田賀 哲也: 神経幹細胞/前駆細胞における細胞周期調節因子cyclin D1のアストロサイト分化抑制機構(Molecular mechanism underlying cyclin D1 mediated inhibition of astrocyte differentiation from neural stem/progenitor cells) 神経化学. 2010.08; 49 (2-3): 536. ( ichushi )

  19. Jungwon Seo, Yoichi Asaoka, Yoko Nagai, Jun Hirayama, Tokiwa Yamasaki, Misako Namae, Shinya Ohata, Nao Shimizu, Takahiro Negishi, Daiju Kitagawa, Hisato Kondoh, Makoto Furutani-Seiki, Josef M Penninger, Toshiaki Katada, Hiroshi Nishina: Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation. J. Cell. Biochem.. 2010.07; 110 (4): 1022-1037. ( PubMed , DOI )

  20. Toshihiko Matsumoto, Shuji Terai, Toshiyuki Oishi, Shinya Kuwashiro, Koichi Fujisawa, Naoki Yamamoto, Yusuke Fujita, Yoshihiko Hamamoto, Makoto Furutani-Seiki, Hiroshi Nishina, Isao Sakaida: Medaka as a model for human nonalcoholic steatohepatitis. Dis Model Mech. 2010.07; 3 (7-8): 431-440. ( PubMed , DOI )

  21. Masahiko Tanaka, Hideyuki Hara, Hiroshi Nishina, Kentaro Hanada, Ken'ichi Hagiwara, Tomohiko Maehama: An improved method for cell-to-cell transmission of infectious prion. Biochem. Biophys. Res. Commun.. 2010.07; 397 (3): 505-508. ( PubMed , DOI )

  22. Inoue Toshihiro, Kagawa Tetsushi, Inoue-Mochita Miyuki, Isono Kyoichi, Ohtsu Naoki, Nobuhisa Ikuo, Fukushima Mikiko, Tanihara Hidenobu, Taga Tetsuya: Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. FEBS Lett. 2010.07; 584 (14): 3233-3238. ( PubMed , DOI )

  23. Yoko Nagai, Yoichi Asaoka, Misako Namae, Kota Saito, Haruka Momose, Hiroshi Mitani, Makoto Furutani-Seiki, Toshiaki Katada, Hiroshi Nishina: The LIM protein Ajuba is required for ciliogenesis and left-right axis determination in medaka. Biochem. Biophys. Res. Commun.. 2010.06; 396 (4): 887-893. ( PubMed , DOI )

  24. Junko Sasaki, Satoshi Kofuji, Reietsu Itoh, Toshihiko Momiyama, Kiyohiko Takayama, Haruka Murakami, Shinsuke Chida, Yuko Tsuya, Shunsuke Takasuga, Satoshi Eguchi, Ken Asanuma, Yasuo Horie, Kouichi Miura, Elizabeth Michele Davies, Christina Mitchell, Masakazu Yamazaki, Hirokazu Hirai, Tadaomi Takenawa, Akira Suzuki, Takehiko Sasaki: The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature. 2010.05; 465 (7297): 497-501. ( PubMed , DOI )

  25. Kentaro Nakagawa, Misato Sugahara, Tokiwa Yamasaki, Hiroaki Kajiho, Shinya Takahashi, Jun Hirayama, Yasuhiro Minami, Yasutaka Ohta, Toshio Watanabe, Yutaka Hata, Toshiaki Katada, Hiroshi Nishina: Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation. Biochem. J.. 2010.04; 427 (2): 237-245. ( PubMed , DOI )

  26. Akira Nifuji, Hisashi Ideno, Yoshio Ohyama, Rieko Takanabe, Ryoko Araki, Masumi Abe, Masaki Noda, Hiroshi Shibuya: Nemo-like kinase (NLK) expression in osteoblastic cells and suppression of osteoblastic differentiation. Exp. Cell Res.. 2010.04; 316 (7): 1127-1136. ( PubMed , DOI )

  27. Uchida Yoshimi, Hirayama Jun, Nishina Hiroshi: 共通起源　体内時計の調節とDNA損傷反応における信号伝達の類似性(A Common Origin: Signaling Similarities in the Regulation of the Circadian Clock and DNA Damage Responses) Biological & Pharmaceutical Bulletin. 2010.04; 33 (4): 535-544. ( ichushi )

  28. Shimizu S, Konishi A, Nishida Y, Mizuta T, Nishina H, Yamamoto A, Tsujimoto Y: Involvement of JNK in the regulation of autophagic cell death. Oncogene. 2010.04; 29 (14): 2070-2082. ( PubMed , DOI )

  29. Takahiro Negishi, Yoko Nagai, Yoichi Asaoka, Mami Ohno, Misako Namae, Hiroshi Mitani, Takashi Sasaki, Nobuyoshi Shimizu, Shuji Terai, Isao Sakaida, Hisato Kondoh, Toshiaki Katada, Makoto Furutani-Seiki, Hiroshi Nishina: Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression in medaka. Hepatology. 2010.03; 51 (3): 1037-1045. ( PubMed , DOI )

  30. Goto T., Ohnishi E., Sato A.(The first three authors contributed equally), Kim M., Iemura S., Ishitani T., Natsume T., Ohnishi J.and Shibuya H.: Nemo-like kinase, an essential effector of anterior formation, functions downstream of p38 MAP kinase. Mol. Cell. Biol.. 2010.02; 30 675-683. ( PubMed , DOI )

  31. Eriko Ohnishi, Toshiyasu Goto, Atsushi Sato, Mi-Sun Kim, Shun-Ichiro Iemura, Tohru Ishitani, Tohru Natsume, Junji Ohnishi, Hiroshi Shibuya: Nemo-like kinase, an essential effector of anterior formation, functions downstream of p38 mitogen-activated protein kinase. Mol. Cell. Biol.. 2010.02; 30 (3): 675-683. ( PubMed , DOI )

  32. Honglu Zhang, Ju He, Tatiana G. Kutateladze, Takahiro Sakai, Takehiko Sasaki, Nicolas Markadieu, Christophe Erneux, Glenn D. Prestwich: 5-Stabilized Phosphatidylinositol 3,4,5-Trisphosphate Analogues Bind Grp1 PH, Inhibit Phosphoinositide Phosphatases, and Block Neutrophil Migration CHEMBIOCHEM. 2010.02; 11 (3): 388-395. ( PubMed , DOI )

  33. Yukihide Watanabe, Susumu Itoh, Toshiyasu Goto, Eriko Ohnishi, Masako Inamitsu, Fumiko Itoh, Kiyotoshi Satoh, Eliza Wiercinska, Weiwen Yang, Liang Shi, Aya Tanaka, Naoko Nakano, A Mieke Mommaas, Hiroshi Shibuya, Peter Ten Dijke, Mitsuyasu Kato: TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling. Mol. Cell. 2010.01; 37 (1): 123-134. ( PubMed , DOI )

  34. Yoshimi Uchida, Jun Hirayama, Hiroshi Nishina: A common origin: signaling similarities in the regulation of the circadian clock and DNA damage responses. Biol. Pharm. Bull.. 2010; 33 (4): 535-544. ( PubMed )

  35. Kagawa Tetsushi, Shimizu Takeshi, Araki Kimi, Takeda Naoki, Nakagata Naomi, Nobuhisa Ikuo, Taga Tetsuya: Analysis of glial cell sub-lineages in the developing central nervous system using GFAP/Cre-reporter mouse system NEUROSCIENCE RESEARCH. 2010; 68 E240. ( DOI )

  36. Bizen Norihisa, Inoue Toshihiro, Shimizu Takeshi, Kagawa Tetsushi, Taga Tetsuya: Molecular mechanism underlying cyclin D1 mediated inhibition of astrocyte differentiation from neural stem/progenitor cells NEUROSCIENCE RESEARCH. 2010; 68 E132. ( DOI )

  37. Takehiko Sasaki, Junko Sasaki, Shunsuke Takasuga, Satoshi Eguchi, Satoshi Kofuji: Physiology of phosphoinositide metabolism JOURNAL OF PHYSIOLOGICAL SCIENCES. 2010; 60 S68.

  38. Neely1 GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmen L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NA, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks A, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM.: A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell. 2010; 141 (1): 142-153. ( DOI )

  39. Tabu Kouichi, Kimura Taichi, Sasai Ken, Wang Lei, Bizen Norihisa, Nishihara Hiroshi, Taga Tetsuya, Tanaka Shinya: Analysis of an alternative human CD133 promoter reveals the implication of Ras/ERK pathway in tumor stem-like hallmarks. Mol Cancer. 2010; 9 39. ( PubMed , DOI )

  40. Masahide Takeda, Wataru Ito, Masako Tanabe, Shigeharu Ueki, Junko Kihara, Hikari Kato, Tomomi Tanigai, Hiroyuki Kayaba, Takehiko Sasaki, Junichi Chihara: The Pathophysiological Roles of PI3Ks and Therapeutic Potential of Selective Inhibitors in Allergic Inflammation INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2010; 152 90-95. ( PubMed , DOI )

  1. Ryota Saito, Tokiwa Yamasaki, Yoko Nagai, Jinzhan Wu, Hiroaki Kajiho, Tadashi Yokoi, Eiichiro Noda, Sachiko Nishina, Hitoshi Niwa, Noriyuki Azuma, Toshiaki Katada, Hiroshi Nishina: CrxOS maintains the self-renewal capacity of murine embryonic stem cells. Biochem. Biophys. Res. Commun.. 2009.12; 390 (4): 1129-1135. ( PubMed , DOI )

  2. Ramadan Ahmed, Nobuhisa Ikuo, Yamasaki Shoutarou, Taga Tetsuya: 造血・リンパ器官形成　幹細胞　マウス胚の胎盤において造血活性をもつ細胞の性状解析(Characterization of cells that have hematopoietic activity in the placenta of mouse embryo) 日本免疫学会総会・学術集会記録. 2009.11; 39 49. ( ichushi )

  3. Fukushima Mikiko, Setoguchi Takao, Komiya Setsuro, Tanihara Hidenobu, Taga Tetsuya: Retinal astrocyte differentiation mediated by leukemia inhibitory factor in cooperation with bone morphogenetic protein 2. Int J Dev Neurosci. 2009.11; 27 (7): 685-690. ( PubMed , DOI )

  4. Takehiko Sasaki, Shunsuke Takasuga, Junko Sasaki, Satoshi Kofuji, Satoshi Eguchi, Masakazu Yamazaki, Akira Suzuki: Mammalian phosphoinositide kinases and phosphatases. Prog. Lipid Res.. 2009.11; 48 (6): 307-343. ( PubMed , DOI )

  5. Jun Hirayama, Norio Miyamura, Yoshimi Uchida, Yoichi Asaoka, Reiko Honda, Kenji Sawanobori, Takeshi Todo, Takuro Yamamoto, Paolo Sassone-Corsi, Hiroshi Nishina: Common light signaling pathways controlling DNA repair and circadian clock entrainment in zebrafish. Cell Cycle. 2009.09; 8 (17): 2794-2801. ( PubMed )

  6. Sanosaka Tsukasa, Namihira Masakazu, Kohyama Jun, Semi Katsunori, Deneen Benjamin, Taga Tetsuya, Nakashima Kinichi: 神経前駆細胞にアストロサイト分化能を与えるエピジェネティック機構(Epigenetic mechanism conferring astrocytic potential on neural precursor cells) Neuroscience Research. 2009.09; 65 (Suppl.1): S19. ( ichushi )

  7. 椨 康一, 田賀 哲也: ラットC6グリオーマ細胞株におけるmain populationによるside populationの維持(Maintenance of side population in C6 glioma by main population) 日本癌学会総会記事. 2009.08; 68回 270. ( ichushi )

  8. Norio Miyamura, Jun Hirayama, Kenji Sawanobori, Teruya Tamaru, Yoichi Asaoka, Reiko Honda, Takuro Yamamoto, Hatsume Uno, Ken Takamatsu, Hiroshi Nishina: CLOCK:BMAL-independent circadian oscillation of zebrafish Cryptochrome1a gene. Biol. Pharm. Bull.. 2009.07; 32 (7): 1183-1187. ( PubMed )

  9. Takashi Nakamura, Hiroshi Nishina: Liver development: lessons from knockout mice and mutant fish. Hepatol. Res.. 2009.07; 39 (7): 633-644. ( PubMed , DOI )

  10. Nao Shimizu, Hajime Watanabe, Junko Kubota, Jinzhan Wu, Ryota Saito, Tadashi Yokoi, Takumi Era, Takeshi Iwatsubo, Takashi Watanabe, Sachiko Nishina, Noriyuki Azuma, Toshiaki Katada, Hiroshi Nishina: Pax6-5a promotes neuronal differentiation of murine embryonic stem cells. Biol. Pharm. Bull.. 2009.06; 32 (6): 999-1003. ( PubMed )

  11. 備前 典久, 井上 俊洋, 清水 健史, 鹿川 哲史, 田賀 哲也: サイクリンD1は神経幹細胞/前駆細胞からの星状細胞分化を細胞周期調節非依存性に抑制する(Cyclin D1 inhibits astrocyte differentiation from neural stem/progenitor cells in a manner independent of cell cycle regulation) 神経化学. 2009.06; 48 (2-3): 205. ( ichushi )

  12. Naoki Kobayashi, Kohjiro Ueki, Takehiko Sasaki, Takashi Kadowaki: Crucial Role of Class IB PI3-Kinase, PI3K gamma, in Obesity-Induced Insulin Resistance DIABETES. 2009.06; 58 A352.

  13. Yumiko Anezaki, Shigetoshi Ohshima, Hajime Ishii, Nobukatsu Kinoshita, Takahiro Dohmen, Ei Kataoka, Wataru Sato, Masahiro Iizuka, Takashi Goto, Junko Sasaki, Takehiko Sasaki, Akira Suzuki, Hirohide Ohnishi, Yasuo Horie: Sex difference in the liver of hepatocyte-specific Pten-deficient mice: A model of nonalcoholic steatohepatitis. Hepatol. Res.. 2009.06; 39 (6): 609-618. ( PubMed , DOI )

  14. Kimura T, Sakai M, Tabu K, Wang L, Tsunematsu R, Tsuda M, Sawa H, Nagashima K, Nishihara H, Hatakeyama S, Nakayama K, Ladanyi M, Tanaka S, Nakayama KI: Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration. Laboratory investigation; a journal of technical methods and pathology. 2009.06; 89 (6): 645-56. ( PubMed , DOI )

  15. 鹿川 哲史, 田賀 哲也: アストロサイトの発生と分化　中枢神経系グリア細胞亜集団の細胞系譜解析(Glial cell sub-lineages in the developing central nervous system) 神経化学. 2009.06; 48 (2-3): 167. ( ichushi )

  16. Dual Role of Cdc42 in Spindle Orientation Control of Adherent Cells 2009.05; 29 (10): 2816-2827. ( PubMed , DOI )

  17. Akihiko Nishikimi, Hideo Fukuhara, Wenjuan Su, Tsunaki Hongu, Shunsuke Takasuga, Hisashi Mihara, Qinhong Cao, Fumiyuki Sanematsu, Motomu Kanai, Hiroshi Hasegawa, Yoshihiko Tanaka, Masakatsu Shibasaki, Yasunori Kanaho, Takehiko Sasaki, Michael A Frohman, Yoshinori Fukui: Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis. Science. 2009.04; 324 (5925): 384-387. ( PubMed , DOI )

  18. Shuhei Tanemura, Haruka Momose, Nao Shimizu, Daiju Kitagawa, Jungwon Seo, Tokiwa Yamasaki, Kentaro Nakagawa, Hiroaki Kajiho, Josef M Penninger, Toshiaki Katada, Hiroshi Nishina: Blockage by SP600125 of Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway. J. Biochem.. 2009.03; 145 (3): 345-354. ( PubMed , DOI )

  19. Hajime Ishii, Yasuo Horie, Shigetoshi Ohshima, Yumiko Anezaki, Nobukatsu Kinoshita, Takahiro Dohmen, Ei Kataoka, Wataru Sato, Takashi Goto, Junko Sasaki, Takehiko Sasaki, Sumio Watanabe, Akira Suzuki, Hirohide Ohnishi: Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. J. Hepatol.. 2009.03; 50 (3): 562-571. ( PubMed , DOI )

  20. Chihiro Mogi, Masayuki Tobo, Hideaki Tomura, Naoya Murata, Xiao-Dong He, Koichi Sato, Takao Kimura, Tamotsu Ishizuka, Takehiko Sasaki, Takashi Sato, Yasuyuki Kihara, Satoshi Ishii, Akihiro Harada, Fumikazu Okajima: Involvement of Proton-Sensing TDAG8 in Extracellular Acidification-Induced Inhibition of Proinflammatory Cytokine Production in Peritoneal Macrophages JOURNAL OF IMMUNOLOGY. 2009.03; 182 (5): 3243-3251. ( PubMed , DOI )

  21. Shinya Ohata, Makiko Nawa, Takeshi Kasama, Tokiwa Yamasaki, Kenji Sawanobori, Shoji Hata, Takashi Nakamura, Yoichi Asaoka, Toshio Watanabe, Hitoshi Okamoto, Takahiko Hara, Shuji Terai, Isao Sakaida, Toshiaki Katada, Hiroshi Nishina: Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells. Biochem. Biophys. Res. Commun.. 2009.02; 379 (4): 817-823. ( PubMed , DOI )

  22. Namihira Masakazu, Kohyama Jun, Semi Katsunori, Sanosaka Tsukasa, Deneen Benjamin, Taga Tetsuya, Nakashima Kinichi: Committed neuronal precursors confer astrocytic potential on residual neural precursor cells. Dev Cell. 2009.02; 16 (2): 245-255. ( PubMed , DOI )

  23. Yanfeng Wang, Xinsheng Chen, Lurong Lian, Tang Tang, Timothy J. Stalker, Takehiko Sasaki, Yasunori Kanaho, Lawrence F. Brass, John K. Choi, John H. Hartwig, Charles S. Abrams: Loss of PIP5KI beta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation (vol 105, pg 14064, 2008) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009.01; 106 (4): 1291. ( DOI )

  24. Katsumori Segawa, Morihiro Matsuda, Atsunori Fukuhara, Kentaro Morita, Yosuke Okuno, Ryutaro Komuro, Iichiro Shimomura: Identification of a novel distal enhancer in human adiponectin gene. J Endocrinol. 2009.01; 200 (1): 107-116. ( PubMed , DOI )

  25. Yoshifumi Matsumoto, Hiroki Oota, Yoichi Asaoka, Hiroshi Nishina, Koji Watanabe, Janusz M Bujnicki, Shoji Oda, Shoji Kawamura, Hiroshi Mitani: Medaka: a promising model animal for comparative population genomics. BMC Res Notes. 2009; 2 88. ( PubMed , DOI )

  26. Sanosaka Tsukasa, Namihira Masakazu, Kohyama Jun, Semi Katsunori, Deneen Benjamin, Taga Tetsuya, Nakashima Kinichi: Epigenetic mechanism conferring astrocytic potential on neural precursor cells NEUROSCIENCE RESEARCH. 2009; 65 S19. ( DOI )

  27. Ryosuke Nakamura, Yoshimi Uchida, Masakazu Higuchi, Reiko Teshima: Development of a novel allergy test using a cultured mast cell line ImmunoTox Letter. 2009; 28 12-13.

  1. Tomohiko Maehama, Masahiko Tanaka, Hiroshi Nishina, Makoto Murakami, Yasunori Kanaho, Kentaro Hanada: RalA functions as an indispensable signal mediator for the nutrient-sensing system. J. Biol. Chem.. 2008.12; 283 (50): 35053-35059. ( PubMed , DOI )

  2. Shimizu Takeshi, Kagawa Tetsushi, Inoue Toshihiro, Nonaka Aya, Takada Shinji, Aburatani Hiroyuki, Taga Tetsuya: Stabilized beta-catenin functions through TCF/LEF proteins and the Notch/RBP-Jkappa complex to promote proliferation and suppress differentiation of neural precursor cells. Mol Cell Biol. 2008.12; 28 (24): 7427-7441. ( PubMed , DOI )

  3. Yamasaki Shoutarou, Nobuhisa Ikuo, Ahmed Gomaa, Taga Tetsuya: 造血　免疫担当細胞初期分化　CD45/c-Kit発現の観点からみた造血能をもつ卵黄嚢細胞の同定(Identification of yolk sac cells having hematopoietic activity in view of CD45/c-Kit expression) 日本免疫学会総会・学術集会記録. 2008.11; 38 134. ( ichushi )

  4. Manando Nakasaki, Kiyoko Yoshioka, Yasuhide Miyamoto, Takehiko Sasaki, Hideki Yoshikawa, Kazuyuki Itoh: IGF-I secreted by osteoblasts acts as a potent chemotactic factor for osteoblasts BONE. 2008.11; 43 (5): 869-879. ( PubMed , DOI )

  5. Tabu K, Sasai K, Kimura T, Wang L, Aoyanagi E, Kohsaka S, Tanino M, Nishihara H, Tanaka S: Promoter hypomethylation regulates CD133 expression in human gliomas. Cell research. 2008.10; 18 (10): 1037-46. ( PubMed , DOI )

  6. Shinya Takahashi, Yasuhiro Araki, Yuriko Ohya, Takeshi Sakuno, Shin-Ichi Hoshino, Kenji Kontani, Hiroshi Nishina, Toshiaki Katada: Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast. RNA. 2008.09; 14 (9): 1950-1958. ( PubMed , DOI )

  7. 椨 康一, 木村 太一, 笹井 研, 田賀 哲也, 田中 伸哉: ヒト腫瘍細胞におけるCD133遺伝子の発現メカニズム(The transcriptional mechanism underlying CD133 expression in human tumor cells) 日本癌学会総会記事. 2008.09; 67回 302. ( ichushi )

  8. Yanfeng Wang, Xinsheng Chen, Lurong Lian, Tang Tang, Timothy J Stalker, Takehiko Sasaki, Yasunori Kanaho, Lawrence F Brass, John K Choi, John H Hartwig, Charles S Abrams: Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. Proc. Natl. Acad. Sci. U.S.A.. 2008.09; 105 (37): 14064-14069. ( PubMed , DOI )

  9. 鹿川 哲史, 清水 健史, 荒木 喜美, 竹田 直樹, 田賀 哲也: 発達期中枢神経系グリア細胞系譜の解析のためのGFAP/Cre-reporterマウス系の確立(Establishment of GFAP/Cre-reporter mouse system to analyze glial cell sub-lineages in the developing central nervous system) 神経化学. 2008.08; 47 (2-3): 255. ( ichushi )

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  11. Shizue Ohsawa, Tomomi Watanabe, Toshiaki Katada, Hiroshi Nishina, Masayuki Miura: Novel antibody to human BASP1 labels apoptotic cells post-caspase activation. Biochem. Biophys. Res. Commun.. 2008.07; 371 (4): 639-643. ( PubMed , DOI )

  12. Tae Inoue-Narita, Koichi Hamada, Takehiko Sasaki, Sachiko Hatakeyama, Sachiko Fujita, Kohichi Kawahara, Masato Sasaki, Hiroyuki Kishimoto, Satoshi Eguchi, Itaru Kojima, Friedrich Beermann, Tetsunori Kimura, Masatake Osawa, Satoshi Itami, Tak Wah Mak, Toru Nakano, Motomu Manabe, Akira Suzuki: Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis. Cancer Res.. 2008.07; 68 (14): 5760-5768. ( PubMed , DOI )

  13. Taga Tetsuya: 神経幹細胞における増殖と分化シグナル伝達経路との交差相互作用(Cross-interactions among growth and differentiation signaling pathways in neural stem cells) Neuroscience Research. 2008.07; 61 (Suppl.1): S19. ( ichushi )

  14. Hirohide Iwasaki, Yoshimichi Murata, Youngjun Kim, Md Israil Hossain, Carolyn A Worby, Jack E Dixon, Thomas McCormack, Takehiko Sasaki, Yasushi Okamura: A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc. Natl. Acad. Sci. U.S.A.. 2008.06; 105 (23): 7970-7975. ( PubMed , DOI )

  15. Shoko Kuroda, Miki Nishio, Takehiko Sasaki, Yasuo Horie, Koichi Kawahara, Masato Sasaki, Miyuki Natsui, Takashi Matozaki, Hiroyuki Tezuka, Toshiaki Ohteki, Irmgard Förster, Tak W Mak, Toru Nakano, Akira Suzuki: Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages. Eur J Immunol. 2008.05; 38 (5): 1331-1340. ( PubMed , DOI )

  16. Nishihara H, Ozaki Y, Ito T, Yoshinaga T, Tabu K, Tanino M, Nagashima K, Tanaka S: A case of cerebral ganglioneuronal tumor in the parietal lobe of an adult. Brain tumor pathology. 2008.04; 25 (1): 45-9. ( PubMed , DOI )

  17. Yoshio Marumoto, Shuji Terai, Yohei Urata, Toshihiko Matsumoto, Yuko Mizunaga, Naoki Yamamoto, Haiyan Jin, Koichi Fujisawa, Tomoaki Murata, Koh Shinoda, Hiroshi Nishina, Isao Sakaida: Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl4-treated cirrhotic liver. Biochem. Biophys. Res. Commun.. 2008.03; 367 (3): 546-552. ( PubMed , DOI )

  18. Goto T., Keller R. and Asashima M.: Concentrations of TBP-type genes affect chordamesodermal gene expression. Int. J. Dev. Biol.. 2008.03; 52 371-375. ( PubMed , DOI )

  19. Kawasaki A., Kumasaka M., Satoh A., Suzuki M., Tamura K., Goto T., Asashima M., Yamamoto H.: Mitf contributes to melanosome distribution and melanophore dendricity. Pigment Cell Melanoma Res.. 2008.02; 21 56-62. ( PubMed , DOI )

  20. Fabien Garçon, Daniel T Patton, Juliet L Emery, Emilio Hirsch, Robert Rottapel, Takehiko Sasaki, Klaus Okkenhaug: CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer. Blood. 2008.02; 111 (3): 1464-1471. ( PubMed , DOI )

  21. Yanfeng Wang, Rustem I Litvinov, Xinsheng Chen, Tami L Bach, Lurong Lian, Brian G Petrich, Susan J Monkley, Yasunori Kanaho, David R Critchley, Takehiko Sasaki, Morris J Birnbaum, John W Weisel, John Hartwig, Charles S Abrams: Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J. Clin. Invest.. 2008.02; 118 (2): 812-819. ( PubMed , DOI )

  22. Akira Suzuki, Toru Nakano, Tak Wah Mak, Takehiko Sasaki: Portrait of PTEN: messages from mutant mice. Cancer Sci.. 2008.02; 99 (2): 209-213. ( PubMed , DOI )

  23. H Kuwana, Y Terada, T Kobayashi, T Okado, J M Penninger, J Irie-Sasaki, T Sasaki, S Sasaki: The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity. Kidney Int.. 2008.02; 73 (4): 430-445. ( PubMed , DOI )

  24. Ken Tsukamoto, Kaoru Hazeki, Megumi Hoshi, Kiyomi Nigorikawa, Norimitsu Inoue, Takehiko Sasaki, Osamu Hazeki: Critical roles of the p110 beta subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells JOURNAL OF IMMUNOLOGY. 2008.02; 180 (4): 2054-2061. ( PubMed , DOI )

  25. T Wada, E Stepniak, L Hui, A Leibbrandt, T Katada, H Nishina, E F Wagner, J M Penninger: Antagonistic control of cell fates by JNK and p38-MAPK signaling. Cell Death Differ.. 2008.01; 15 (1): 89-93. ( PubMed , DOI )

  26. Hisamoto N, Moriguchi T, Urushiyama S, Mitani S, Shibuya H, Matsumoto K: Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity. EMBO Rep. 2008.01; 9 (1): 70-75. ( PubMed , DOI )

  1. PtdIns(3,4,5)P3 regulates spindle orientation in adherent cells 2007.12; 13 (6): 796-811. ( PubMed , DOI )

  2. Maiko Nozaki, Atsunori Fukuhara, Katsumori Segawa, Yosuke Okuno, Manabu Abe, Naomi Hosogai, Morihiro Matsuda, Ryutaro Komuro, Iichiro Shimomura: Nitric oxide dysregulates adipocytokine expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2007.12; 364 (1): 33-39. ( PubMed , DOI )

  3. Kristy A Horan, Ken-Ichi Watanabe, Anne M Kong, Charles G Bailey, John E J Rasko, Takehiko Sasaki, Christina A Mitchell: Regulation of FcgammaR-stimulated phagocytosis by the 72-kDa inositol polyphosphate 5-phosphatase: SHIP1, but not the 72-kDa 5-phosphatase, regulates complement receptor 3 mediated phagocytosis by differential recruitment of these 5-phosphatases to the phagocytic cup. Blood. 2007.12; 110 (13): 4480-4491. ( PubMed , DOI )

  4. Spindle orientation in animal cell mitosis: Roles of integrin in the control of spindle axis 2007.11; 213 (2): 407-411. ( PubMed , DOI )

  5. Wang L, Tabu K, Kimura T, Tsuda M, Linghu H, Tanino M, Kaneko S, Nishihara H, Tanaka S: Signaling adaptor protein Crk is indispensable for malignant feature of glioblastoma cell line KMG4. Biochemical and biophysical research communications. 2007.11; 362 (4): 976-81. ( PubMed , DOI )

  6. Satoh K, Ohnishi J, Sato A, Takeyama M, Iemura S, Natsume T, Shibuya H: Nemo-like kinase-myocyte enhancer factor 2A signaling regulates anterior formation in Xenopus development. Mol Cell Biol. 2007.11; 27 (21): 7623-7630. ( PubMed , DOI )

  7. Nobuhisa Ikuo, Yamasaki Shoutarou, Gomaa Ahmed, Taga Tetsuya: 大動脈-性腺-中腎領域における造血活性を持つ細胞集団の同定(Identification of a population of cells having hematopoietic activity in the aorta-gonad-mesonephros region) 日本免疫学会総会・学術集会記録. 2007.10; 37 47. ( ichushi )

  8. Shigehisa Yanagi, Hiroyuki Kishimoto, Kohichi Kawahara, Takehiko Sasaki, Masato Sasaki, Miki Nishio, Nobuyuki Yajima, Koichi Hamada, Yasuo Horie, Hiroshi Kubo, Jeffrey A Whitsett, Tak Wah Mak, Toru Nakano, Masamitsu Nakazato, Akira Suzuki: Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J. Clin. Invest.. 2007.10; 117 (10): 2929-2940. ( PubMed , DOI )

  9. Tabu K, Ohba Y, Suzuki T, Makino Y, Kimura T, Ohnishi A, Sakai M, Watanabe T, Tanaka S, Sawa H: Oligodendrocyte lineage transcription factor 2 inhibits the motility of a human glial tumor cell line by activating RhoA. Molecular cancer research : MCR. 2007.10; 5 (10): 1099-109. ( PubMed , DOI )

  10. Takashi Nakamura, Yuuki Imai, Takahiro Matsumoto, Shingo Sato, Kazusane Takeuchi, Katsuhide Igarashi, Yoshifumi Harada, Yoshiaki Azuma, Andree Krust, Yoko Yamamoto, Hiroshi Nishina, Shu Takeda, Hiroshi Takayanagi, Daniel Metzger, Jun Kanno, Kunio Takaoka, T John Martin, Pierre Chambon, Shigeaki Kato: Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell. 2007.09; 130 (5): 811-823. ( PubMed , DOI )

  11. Takehiko Sasaki, Junko Sasaki, Takahiro Sakai, Shunsuke Takasuga, Akira Suzuki: The physiology of phosphoinositides. Biol. Pharm. Bull.. 2007.09; 30 (9): 1599-1604. ( PubMed )

  12. Inoue Toshihiro, Kawaji Takahiro, Inoue-Mochita Miyuki, Taga Tetsuya, Tanihara Hidenobu: Media conditioned by retinal pigment epithelial cells suppress the canonical Wnt pathway. Neurosci Lett. 2007.09; 424 (3): 190-193. ( PubMed , DOI )

  13. Seiji Ura, Hiroshi Nishina, Yukiko Gotoh, Toshiaki Katada: Activation of the c-Jun N-terminal kinase pathway by MST1 is essential and sufficient for the induction of chromatin condensation during apoptosis. Mol. Cell. Biol.. 2007.08; 27 (15): 5514-5522. ( PubMed , DOI )

  14. Shimizu Takeshi, Kagawa Tetsushi, Inoue Toshihiro, Takada Shinji, Taga Tetsuya: グリコーゲン合成酵素キナーゼ3βとβ-cateninによる、終脳神経前駆細胞の分裂と分化の調整(A role for glycogen synthase kinase 3β and β-catenin in coordinating proliferation and differentiation of telencephalic neural precursor cells) 神経化学. 2007.08; 46 (2-3): 379. ( ichushi )

  15. Kagawa Tetsushi, Yoshinaga Yutaka, Shimizu Takeshi, Inoue Toshihiro, Takada Shinji, Taga Tetsuya: Wnt3aシグナリングによるマウス海馬前駆細胞の細胞周期調節(Wnt3a promotes mouse hippcampal progenitor cell proliferation by shortening cell cycle) 神経化学. 2007.08; 46 (2-3): 409. ( ichushi )

  16. Yutaka Furutani, Hitomi Matsuno, Miwa Kawasaki, Takehiko Sasaki, Kensaku Mori, Yoshihiro Yoshihara: Interaction between telencephalin and ERM family proteins mediates dendritic filopodia formation JOURNAL OF NEUROSCIENCE. 2007.08; 27 (33): 8866-8876. ( PubMed , DOI )

  17. Masaki Tanaka, Maiko Nozaki, Atsunori Fukuhara, Katsumori Segawa, Naohito Aoki, Morihiro Matsuda, Ryutaro Komuro, Iichiro Shimomura: Visfatin is released from 3T3-L1 adipocytes via a non-classical pathway. Biochem Biophys Res Commun. 2007.07; 359 (2): 194-201. ( PubMed , DOI )

  18. Fukuda Shinji, Abematsu Masahiko, Mori Hiroyuki, Yanagisawa Makoto, Kagawa Tetsushi, Nakashima Kinichi, Yoshimura Akihiko, Taga Tetsuya: Potentiation of astrogliogenesis by STAT3-mediated activation of bone morphogenetic protein-Smad signaling in neural stem cells. Mol Cell Biol. 2007.07; 27 (13): 4931-4937. ( PubMed , DOI )

  19. Sasai K, Akagi T, Aoyanagi E, Tabu K, Kaneko S, Tanaka S: O6-methylguanine-DNA methyltransferase is downregulated in transformed astrocyte cells: implications for anti-glioma therapies. Molecular cancer. 2007.06; 6 36. ( PubMed , DOI )

  20. 福田 信治, 清水 健史, 井上 俊洋, 鹿川 哲史, 田賀 哲也: 幹細胞制御の分子学的基礎　成長中のマウス脳における細胞運命決定の分子学的基礎(Molecular basis for stem cell regulation　Molecular basis for cell-fate determination in the developing mouse brain) 日本発生生物学会・日本細胞生物学会合同大会要旨集. 2007.05; 40回・59回 23. ( ichushi )

  21. Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1 2007.05; 282 (20): 15217-15227. ( PubMed , DOI )

  22. 清水 健史, 鹿川 哲史, 井上 俊洋, 高田 慎治, 田賀 哲也: 細胞増殖・細胞分化・細胞死・幹細胞　神経前駆細胞の増殖及び分化の調整におけるグリコーゲンシンターゼキナーゼ3βとβ-カテニンの役割(A Role for Glycogen Synthase Kinase 3beta and Beta-Catenin in Coordinating Proliferation and Differentiation of Neural Precursor Cells) 日本発生生物学会・日本細胞生物学会合同大会要旨集. 2007.05; 40回・59回 61. ( ichushi )

  23. Yang Sung-Sen, Morimoto Tetsuji, Rai Tatemitsu, Chiga Motoko, Sohara Eisei, Ohno Mayuko, Uchida Keiko, Lin Shih-Hua, Moriguchi Tetsuo, Shibuya Hiroshi, Kondo Yoshiaki, Sasaki Sei, Uchida Shinichi: Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab. 2007.05; 5 (5): 331-344. ( PubMed , DOI )

  24. Naomi Hosogai, Atsunori Fukuhara, Kazuya Oshima, Yugo Miyata, Sachiyo Tanaka, Katsumori Segawa, Shigetada Furukawa, Yoshihiro Tochino, Ryutaro Komuro, Morihiro Matsuda, Iichiro Shimomura: Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes. 2007.04; 56 (4): 901-911. ( PubMed , DOI )

  25. T Sasaki, J Sasaki, K Watanabe, A Suzuki: Non-invasive visualization of the lipid product of class I PI3K in transgenic mouse models. Biochem. Soc. Trans.. 2007.04; 35 (Pt 2): 215-218. ( PubMed , DOI )

  26. Hiroyuki Kishimoto, Toshiaki Ohteki, Nobuyuki Yajima, Koichi Kawahara, Miyuki Natsui, Satoru Kawarasaki, Koichi Hamada, Yasuo Horie, Yoshiaki Kubo, Seiji Arase, Masaru Taniguchi, Bart Vanhaesebroeck, Tak Wah Mak, Toru Nakano, Shigeo Koyasu, Takehiko Sasaki, Akira Suzuki: The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells. Blood. 2007.04; 109 (8): 3316-3324. ( PubMed , DOI )

  27. A. Suzuki, K. Hamada, T. Sasaki, T. W. Mak, T. Nakano: Role of PTEN/PI3K pathway ire endothelial cells BIOCHEMICAL SOCIETY TRANSACTIONS. 2007.04; 35 172-176.

  28. A. Suzuki, K. Hamada, T. Sasaki, T. W. Mak, T. Nakano: Role of PTEN/PI3K pathway ire endothelial cells BIOCHEMICAL SOCIETY TRANSACTIONS. 2007.04; 35 172-176.

  29. Tsuyoshi Ishikawa, Shuji Terai, Yohei Urata, Yoshio Marumoto, Koji Aoyama, Tomoaki Murata, Yuko Mizunaga, Naoki Yamamoto, Hiroshi Nishina, Koh Shinoda, Isao Sakaida: Administration of fibroblast growth factor 2 in combination with bone marrow transplantation synergistically improves carbon-tetrachloride-induced liver fibrosis in mice. Cell Tissue Res.. 2007.03; 327 (3): 463-470. ( PubMed , DOI )

  30. Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1-and myosin X-dependent manner 2007.03; 26 (6): 1487-1498. ( PubMed , DOI )

  31. Suzawa K., Yukita A., Hayata T., Goto T., Danno H., Michiue T., Cho K.W., Asashima M.: Xenopus glucose transporter 1 (xGLUT1) is required for gastrulation movement in Xenopus laevis. Int. J. Dev. Biol.. 2007.03; 51 183-190. ( PubMed , DOI )

  32. Goto T., Fukui A. (The first two authors contributed equally), Kitamoto J., Homma M., Asashima M.: SDF-1 alpha regulates mesendodermal cell migration during frog gastrulation. Biochem. Biophys. Res. Commun.. 2007.03; 354 422-427. ( PubMed , DOI )

  33. Nobuhisa Ikuo, Ohtsu Naoki, Okada Seiji, Nakagata Naomi, Taga Tetsuya: Identification of a population of cells with hematopoietic stem cell properties in mouse aorta-gonad-mesonephros cultures. Exp Cell Res. 2007.03; 313 (5): 965-974. ( PubMed , DOI )

  34. Matsubara Y, Kawasaki I, Urushiyama S, Yasuda T, Shirakata M, Iino Y, Shibuya H, Yamanashi Y: The adaptor-like protein ROG-1 is required for activation of the Ras-MAP kinase pathway and meiotic cell cycle progression in Caenorhabditis elegans. Genes Cells. 2007.03; 12 (3): 407-420. ( PubMed , DOI )

  35. Shoji Hata, Misako Namae, Hiroshi Nishina: Liver development and regeneration: from laboratory study to clinical therapy. Dev. Growth Differ.. 2007.02; 49 (2): 163-170. ( PubMed , DOI )

  36. G John Ferguson, Laura Milne, Suhasini Kulkarni, Takehiko Sasaki, Simon Walker, Simon Andrews, Tom Crabbe, Peter Finan, Gareth Jones, Shaun Jackson, Montserrat Camps, Christian Rommel, Matthias Wymann, Emilio Hirsch, Phillip Hawkins, Len Stephens: PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis. Nat. Cell Biol.. 2007.01; 9 (1): 86-91. ( PubMed , DOI )

  37. Miki Nishio, Ken-ichi Watanabe, Junko Sasaki, Choji Taya, Shunsuke Takasuga, Ryota Iizuka, Tamas Balla, Masakazu Yamazaki, Hiroshi Watanabe, Reietsu Itoh, Shoko Kuroda, Yasuo Horie, Irmgard Förster, Tak W Mak, Hiromichi Yonekawa, Josef M Penninger, Yasunori Kanaho, Akira Suzuki, Takehiko Sasaki: Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat. Cell Biol.. 2007.01; 9 (1): 36-44. ( PubMed , DOI )

  38. Ohtsu Naoki, Nobuhisa Ikuo, Mochita Miyuki, Taga Tetsuya: Inhibitory effects of homeodomain-interacting protein kinase 2 on the aorta-gonad-mesonephros hematopoiesis. Exp Cell Res. 2007.01; 313 (1): 88-97. ( PubMed , DOI )

  39. Yutaka Furutani, Hitomi Matsuno, Miwa Kawasaki, Takehiko Sasaki, Kensaku Mori, Yoshihiro Yoshihara: Dendritic filopodia formation is mediated by the interaction between telencephalin and ERM proteins NEUROSCIENCE RESEARCH. 2007; 58 S130.

  1. Miwa Hebiguchi, Makoto Hirokawa, Yong-Mei Guo, Yoshinari Kawabata, Atsushi Komatsuda, Takehiko Sasaki, Yuichi Takakuwa, Ken-ichi Sawada: Enucleation of human erythroblasts is a process of asymmetric cytokinesis. BLOOD. 2006.11; 108 (11): 474A.

  2. Nobuhisa Ikuo, Ohtsu Naoki, Taga Tetsuya: 造血細胞・リンパ球とリンパ組織の発生分化　培養マウス大動脈-性腺-中腎細胞における造血幹細胞特性を有するサイドポピュレーションの同定(Identification of a side population with hematopoietic stem cell property in cultured mouse aorta-gonad-mesonephros cells) 日本免疫学会総会・学術集会記録. 2006.11; 36 94. ( ichushi )

  3. Katsumori Segawa, Atsunori Fukuhara, Naomi Hosogai, Kentaro Morita, Yosuke Okuno, Masaki Tanaka, Yasuhiko Nakagawa, Shinji Kihara, Tohru Funahashi, Ryutaro Komuro, Morihiro Matsuda, Iichiro Shimomura: Visfatin in adipocytes is upregulated by hypoxia through HIF1alpha-dependent mechanism. Biochem Biophys Res Commun. 2006.10; 349 (3): 875-882. ( PubMed , DOI )

  4. Hiroshi Tsuruta, Hiroyuki Kishimoto, Takehiko Sasaki, Yasuo Horie, Miyuki Natsui, Yoshiko Shibata, Koichi Hamada, Nobuyuki Yajima, Koichi Kawahara, Masato Sasaki, Norihiko Tsuchiya, Katsuhiko Enomoto, Tak Wah Mak, Toru Nakano, Tomonori Habuchi, Akira Suzuki: Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients. Cancer Res.. 2006.09; 66 (17): 8389-8396. ( PubMed , DOI )

  5. Kagawa Tetsushi, Shimizu Takeshi, Inoue Toshihiro, Yoshinaga Yutaka, Taga Tetsuya: 増殖中の神経前駆細胞から分化する神経細胞へ転換する分子機構(A molecular basis of transition from proliferating neural precursor cells to differentiating neurons) 神経化学. 2006.08; 45 (2-3): 337. ( ichushi )

  6. Yuya Kunisaki, Akihiko Nishikimi, Yoshihiko Tanaka, Ryosuke Takii, Mayuko Noda, Ayumi Inayoshi, Ken-ichi Watanabe, Fumiyuki Sanematsu, Takehiko Sasazuki, Takehiko Sasaki, Yoshinori Fukui: DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis. J. Cell Biol.. 2006.08; 174 (5): 647-652. ( PubMed , DOI )

  7. Teruhiko Suzuki, Yoshiakira Kanai, Takahiko Hara, Junko Sasaki, Takehiko Sasaki, Michinori Kohara, Tomohiko Maehama, Choji Taya, Hiroshi Shitara, Hiromichi Yonekawa, Michael A Frohman, Takeaki Yokozeki, Yasunori Kanaho: Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol. Cell. Biol.. 2006.08; 26 (16): 6149-6156. ( PubMed , DOI )

  8. Daiju Kitagawa, Hiroaki Kajiho, Takahiro Negishi, Seiji Ura, Tomomi Watanabe, Teiji Wada, Hidenori Ichijo, Toshiaki Katada, Hiroshi Nishina: Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation. EMBO J.. 2006.07; 25 (14): 3286-3297. ( PubMed , DOI )

  9. Nakashima Kinichi, Kohyma Jun, Taga Tetsuya, Namihira Masakazu: 神経幹細胞の星状膠細胞分化能のノッチ-誘発性獲得(Notch-induced acquisition of astrocyte differentiation potential of neural stem cells) Neuroscience Research. 2006.07; 55 (Suppl.1): S36. ( ichushi )

  10. Min Zhao, Bing Song, Jin Pu, Teiji Wada, Brian Reid, Guangping Tai, Fei Wang, Aihua Guo, Petr Walczysko, Yu Gu, Takehiko Sasaki, Akira Suzuki, John V Forrester, Henry R Bourne, Peter N Devreotes, Colin D McCaig, Josef M Penninger: Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature. 2006.07; 442 (7101): 457-460. ( PubMed , DOI )

  11. Yamada M, Ohnishi J, Ohkawara B, Iemura S, Satoh K, Hyodo-Miura J, Kawachi K, Natsume T, Shibuya H: NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF). J Biol Chem. 2006.07; 281 (30): 20749-20760. ( PubMed , DOI )

  12. Yuichiro Yokoyama, Shuji Terai, Tsuyoshi Ishikawa, Koji Aoyama, Yohei Urata, Yoshio Marumoto, Hiroshi Nishina, Kazuyuki Nakamura, Kiwamu Okita, Isao Sakaida: Proteomic analysis of serum marker proteins in recipient mice with liver cirrhosis after bone marrow cell transplantation. Proteomics. 2006.04; 6 (8): 2564-2570. ( PubMed , DOI )

  13. Wataru Sato, Yasuo Horie, Ei Kataoka, Shigetoshi Ohshima, Takahiro Dohmen, Masahiro Iizuka, Junko Sasaki, Takehiko Sasaki, Koichi Hamada, Hiroyuki Kishimoto, Akira Suzuki, Sumio Watanabe: Hepatic gene expression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge. Hepatol. Res.. 2006.04; 34 (4): 256-265. ( PubMed , DOI )

  14. Takizawa Hitoshi, Kubo-Akashi Chiyomi, Nobuhisa Ikuo, Kwon Sang-Mo, Iseki Masanori, Taga Tetsuya, Takatsu Kiyoshi, Takaki Satoshi: Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk. Blood. 2006.04; 107 (7): 2968-2975. ( PubMed , DOI )

  15. Abematsu Masahiko, Kagawa Tetsushi, Fukuda Shinji, Inoue Toshihiro, Takebayashi Hirohide, Komiya Setsuro, Taga Tetsuya: Basic fibroblast growth factor endows dorsal telencephalic neural progenitors with the ability to differentiate into oligodendrocytes but not gamma-aminobutyric acidergic neurons. J Neurosci Res. 2006.04; 83 (5): 731-743. ( PubMed , DOI )

  16. Tabu K, Ohnishi A, Sunden Y, Suzuki T, Tsuda M, Tanaka S, Sakai T, Nagashima K, Sawa H: A novel function of OLIG2 to suppress human glial tumor cell growth via p27Kip1 transactivation. Journal of cell science. 2006.04; 119 (Pt 7): 1433-41. ( PubMed , DOI )

  17. Tsuyoshi Ishikawa, Shuji Terai, Yohei Urata, Yoshio Marumoto, Koji Aoyama, Isao Sakaida, Tomoaki Murata, Hiroshi Nishina, Koh Shinoda, Shunji Uchimura, Yoshihiko Hamamoto, Kiwamu Okita: Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes. Cell Tissue Res.. 2006.02; 323 (2): 221-231. ( PubMed , DOI )

  18. Honma M, Higuchi O, Shirakata M, Yasuda T, Shibuya H, Iemura S, Natsume T, Yamanashi Y: Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases. Genes Cells. 2006.02; 11 (2): 143-151. ( PubMed , DOI )

  19. Teiji Wada, Tomoki Nakashima, Nishina Hiroshi, Josef M Penninger: RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends Mol Med. 2006.01; 12 (1): 17-25. ( PubMed , DOI )

  20. Inoue Toshihiro, Kagawa Tetsushi, Fukushima Mikiko, Shimizu Takeshi, Yoshinaga Yutaka, Takada Shinji, Tanihara Hidenobu, Taga Tetsuya: Activation of canonical Wnt pathway promotes proliferation of retinal stem cells derived from adult mouse ciliary margin. Stem Cells. 2006.01; 24 (1): 95-104. ( PubMed , DOI )

  1. Isao Sakaida, Shuji Terai, Hiroshi Nishina, Kiwamu Okita: Development of cell therapy using autologous bone marrow cells for liver cirrhosis. Med Mol Morphol. 2005.12; 38 (4): 197-202. ( PubMed , DOI )

  2. Yanagisawa Makoto, Taga Tetsuya, Nakamura Kazuo, Ariga Toshio, Yu Robert K: Characterization of glycoconjugate antigens in mouse embryonic neural precursor cells. J Neurochem. 2005.12; 95 (5): 1311-1320. ( PubMed , DOI )

  3. Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H: WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J Biol Chem. 2005.12; 280 (52): 42685-42693. ( PubMed , DOI )

  4. Masataka Asagiri, Kojiro Sato, Takako Usami, Sae Ochi, Hiroshi Nishina, Hiroki Yoshida, Ikuo Morita, Erwin F Wagner, Tak W Mak, Edgar Serfling, Hiroshi Takayanagi: Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J. Exp. Med.. 2005.11; 202 (9): 1261-1269. ( PubMed , DOI )

  5. Hagihara K, Nishikawa T, Sugamata Y, Song J, Isobe T, Taga T, Yoshizaki K: Essential role of STAT3 in cytokine-driven NF-kappaB-mediated serum amyloid A gene expression. Genes to cells : devoted to molecular & cellular mechanisms. 2005.11; 10 (11): 1051-63. ( PubMed , DOI )

  6. Yanagisawa Makoto, Nakashima Kinichi, Ochiai Wataru, Takizawa Takumi, Setoguchi Takao, Uemura Atsumi, Takizawa Makiko, Nobuhisa Ikuo, Taga Tetsuya: 凝集培養による海馬星状膠細胞の神経細胞系統への運命切り換え(Fate redirection of hippocampal astrocytes toward neuronal lineage by aggregate culture) Neuroscience Research. 2005.10; 53 (2): 176-182. ( ichushi )

  7. Yanagisawa Makoto, Nakashima Kinichi, Ochiai Wataru, Takizawa Takumi, Setoguchi Takao, Uemura Atsumi, Takizawa Makiko, Nobuhisa Ikuo, Taga Tetsuya: Fate redirection of hippocampal astrocytes toward neuronal lineage by aggregate culture. Neurosci Res. 2005.10; 53 (2): 176-182. ( PubMed , DOI )

  8. Yanagisawa Makoto, Nakamura Kazuo, Taga Tetsuya: Glycosphingolipid合成阻害剤は胚性神経前駆細胞においてRas-MAPK経路のサイトカイン誘導活性化を抑制する(Glycosphingolipid Synthesis Inhibitor Represses Cytokine-Induced Activation of the Ras-MAPK Pathway in Embryonic Neural Precursor Cells) The Journal of Biochemistry. 2005.09; 138 (3): 285-291. ( ichushi )

  9. Yanagisawa Makoto, Nakamura Kazuo, Taga Tetsuya: Glycosphingolipid synthesis inhibitor represses cytokine-induced activation of the Ras-MAPK pathway in embryonic neural precursor cells. J Biochem. 2005.09; 138 (3): 285-291. ( PubMed , DOI )

  10. Mawatari Yuki, Fukushima Mikiko, Inoue Toshihiro, Setoguchi Takao, Taga Tetsuya, Tanihara Hidenobu: Preferential differentiation of neural progenitor cells into the glial lineage through gp130 signaling in N-methyl-D-aspartate-treated retinas. Brain Res. 2005.09; 1055 (1-2): 7-14. ( PubMed , DOI )

  11. Koichi Hamada, Takehiko Sasaki, Pandelakis A Koni, Miyuki Natsui, Hiroyuki Kishimoto, Junko Sasaki, Nobuyuki Yajima, Yasuo Horie, Go Hasegawa, Makoto Naito, Jun-Ichi Miyazaki, Toshio Suda, Hiroshi Itoh, Kazuwa Nakao, Tak Wah Mak, Toru Nakano, Akira Suzuki: The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev.. 2005.09; 19 (17): 2054-2065. ( PubMed , DOI )

  12. 波平 昌一, 神山 淳, 田賀 哲也, 中島 欽一: 神経幹細胞の発生・維持の分子機構　星状細胞特異的遺伝子プロモーターにおける脱メチル化の促進がNotchシグナル伝達によりもたらされる(Accelerated demethylation in an astrocyte specific gene promoter mediated by Notch-signaling) 神経化学. 2005.08; 44 (2-3): 169. ( ichushi )

  13. 清水 健史, 鹿川 哲史, 井上 俊洋, 吉永 豊, 田賀 哲也: 繊維芽細胞増殖因子2はグリコーゲン合成酵素キナーゼ3βを不活性化することによって未分化状体の神経幹細胞を維持し増殖を促進する(Fibroblast growth factor 2 maintains neural stem cells in an undifferentiated state and promotes their proliferation via the glycogen synthase kinase 3β inactivation) 神経化学. 2005.08; 44 (2-3): 224. ( ichushi )

  14. 鹿川 哲史, 吉永 豊, 清水 健史, 井上 俊洋, 田賀 哲也: Wnt-3aは神経幹細胞の増殖と海馬発達に際しての神経細胞分化を共に促進する(Wnt-3a promotes both neural progenitor proliferation and neuronal differentiation during hippocampal development) 神経化学. 2005.08; 44 (2-3): 184. ( ichushi )

  15. Ohnishi J, Ohnishi E, Shibuya H, Takahashi T: Functions for proteinases in the ovulatory process. Biochim Biophys Acta. 2005.08; 1751 (1): 95-109. ( PubMed , DOI )

  16. Taga Tetsuya, Kagawa Tetsushi, Fukuda Shinji, Shimizu Takeshi, Inoue Toshihiro: サイトカインシグナルは神経発達における細胞運命決定に関与する(Cytokine signals involved in cell fate determination during neural development) Neuroscience Research. 2005.07; 52 (Suppl.): S38. ( ichushi )

  17. Namihira Masakazu, Aonuma Makoto, Setoguchi Hiroki, Kohyama Jun, Taga Tetsuya, Nakashima Kinichi: Notch誘発DNA脱メチル化は神経幹細胞の運命決定に関与する(Notch-induced DNA demethylation involved in fate determination of neural stem cells) Neuroscience Research. 2005.07; 52 (Suppl.): S67. ( ichushi )

  18. Taga Tetsuya, Fukuda Shinji: Role of IL-6 in the neural stem cell differentiation. Clin Rev Allergy Immunol. 2005.06; 28 (3): 249-256. ( PubMed , DOI )

  19. Taro Takami, Shuji Terai, Yuichiro Yokoyama, Haruko Tanimoto, Kunihiko Tajima, Koichi Uchida, Takahiro Yamasaki, Isao Sakaida, Hiroshi Nishina, Snorri S Thorgeirsson, Kiwamu Okita: Human homologue of maid is a useful marker protein in hepatocarcinogenesis. Gastroenterology. 2005.05; 128 (5): 1369-1380. ( PubMed )

  20. Goto T., Davidson L., Asashima M., Keller R.: Planar cell polarity genes regulate polarized extracellular matrix deposition during frog gastrulation. Curr. Biol.. 2005.04; 15 787-793. ( PubMed , DOI )

  21. Shimozaki Koji, Namihira Masakazu, Nakashima Kinichi, Taga Tetsuya: Stage- and site-specific DNA demethylation during neural cell development from embryonic stem cells. J Neurochem. 2005.04; 93 (2): 432-439. ( PubMed , DOI )

  22. Kota Saito, Yasuhiro Araki, Kenji Kontani, Hiroshi Nishina, Toshiaki Katada: Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin. J. Biochem.. 2005.03; 137 (3): 423-430. ( PubMed , DOI )

  23. Fukuda Shinji, Taga Tetsuya: 発達期マウスの脳における転写シグナル系によって制御される細胞発生運命の決定(Cell fate determination regulated by a transcriptional signal network in the developing mouse brain) Anatomical Science International. 2005.03; 80 (1): 12-18. ( ichushi )

  24. Fukuda Shinji, Taga Tetsuya: Cell fate determination regulated by a transcriptional signal network in the developing mouse brain. Anat Sci Int. 2005.03; 80 (1): 12-18. ( PubMed , DOI )

  25. Junko Sasaki, Takehiko Sasaki, Masakazu Yamazaki, Kunie Matsuoka, Choji Taya, Hiroshi Shitara, Shunsuke Takasuga, Miki Nishio, Katsunori Mizuno, Teiji Wada, Hideyuki Miyazaki, Hiroshi Watanabe, Ryota Iizuka, Shuichi Kubo, Shigeo Murata, Tomoki Chiba, Tomohiko Maehama, Koichi Hamada, Hiroyuki Kishimoto, Michael A Frohman, Keiji Tanaka, Josef M Penninger, Hiromichi Yonekawa, Akira Suzuki, Yasunori Kanaho: Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J. Exp. Med.. 2005.03; 201 (6): 859-870. ( PubMed , DOI )

  26. Fukuda Shinji, Taga Tetsuya: 中枢神経系の発達および再生中の神経幹細胞の制御(Regulation of neural stem cells during development and regeneration of the central nervous system) 炎症・再生. 2005.01; 25 (1): 18-25. ( ichushi )

  27. Shuji Terai, Isao Sakaida, Hiroshi Nishina, Kiwamu Okita: Lesson from the GFP/CCl4 model--translational research project: the development of cell therapy using autologous bone marrow cells in patients with liver cirrhosis. J Hepatobiliary Pancreat Surg. 2005; 12 (3): 203-207. ( PubMed , DOI )

  28. Kota Saito, Hiroaki Kajiho, Yasuhiro Araki, Hiroshi Kurosu, Kenji Kontani, Hiroshi Nishina, Toshiaki Katada: Purification and analysis of RIN family-novel Rab5 GEFs. Meth. Enzymol.. 2005; 403 276-283. ( PubMed , DOI )

  29. 和田悌司, 中島友樹, 仁科博史, Josef M Penninger: アダプター分子Gab2は骨密度を制御する 細胞工学. 2005; (24): 704-705.

  1. Adachi S, Jigami T, Yasui T, Nakano T, Ohwada S, Omori Y, Sugano S, Ohkawara B, Shibuya H, Nakamura T, Akiyama T: Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling. Cancer Res. 2004.12; 64 (23): 8496-8501. ( PubMed , DOI )

  2. Aoyama Y, Urushiyama S, Yamada M, Kato C, Ide H, Higuchi S, Akiyama T, Shibuya H: MFB-1, an F-box-type ubiquitin ligase, regulates TGF-beta signalling. Genes Cells. 2004.11; 9 (11): 1093-1101. ( PubMed , DOI )

  3. Okita Keisuke, Kiyonari Hiroshi, Nobuhisa Ikuo, Kimura Naoki, Aizawa Shinichi, Taga Tetsuya: Targeted disruption of the mouse ELYS gene results in embryonic death at peri-implantation development. Genes Cells. 2004.11; 9 (11): 1083-1091. ( PubMed , DOI )

  4. Yanagisawa Makoto, Nakamura Kazuo, Taga Tetsuya: Roles of lipid rafts in integrin-dependent adhesion and gp130 signalling pathway in mouse embryonic neural precursor cells. Genes Cells. 2004.09; 9 (9): 801-809. ( PubMed , DOI )

  5. Setoguchi Takao, Nakashima Kinichi, Takizawa Takumi, Yanagisawa Makoto, Ochiai Wataru, Okabe Masaru, Yone Kazunori, Komiya Setsuro, Taga Tetsuya: Treatment of spinal cord injury by transplantation of fetal neural precursor cells engineered to express BMP inhibitor. Exp Neurol. 2004.09; 189 (1): 33-44. ( PubMed , DOI )

  6. H Watanabe, T Yokozeki, M Yamazaki, H Miyazaki, T Sasaki, T Maehama, K Itoh, MA Frohman, Y Kanaho: Essential role for phospholipase D2 activation downstream of ERK MAP kinase in nerve growth factor-stimulated neurite outgrowth from PC12 cells JOURNAL OF BIOLOGICAL CHEMISTRY. 2004.09; 279 (36): 37870-37877. ( PubMed , DOI )

  7. 中島 欽一, Hsieh Jenny, 桑原 知子, 田賀 哲也, Gage Fred: ヒストン脱アセチル化阻害剤による神経幹細胞のニューロン分化誘導(HDAC inhibitor-mediated neuronal differentiation of adult neural progenitors) 神経化学. 2004.08; 43 (2-3): 396. ( ichushi )

  8. 鹿川 哲史, 荒木 喜美, 田賀 哲也: EmxとDlx発現細胞の細胞系譜解析(In utero fate mapping of Emx- and Dlx-expressing cells in the mouse forebrain) 神経化学. 2004.08; 43 (2-3): 483. ( ichushi )

  9. 清水 健史, 鹿川 哲史, 田賀 哲也: FGF2による神経幹細胞分化制御機構の解析(FGF2 signaling regulates proliferation and maintenance of multipotentiality of neural stem cells via the glycogen synthase kinase3β pathway) 神経化学. 2004.08; 43 (2-3): 487. ( ichushi )

  10. あべ松 昌彦, 鹿川 哲史, 福田 信治, 井上 俊洋, 田賀 哲也: bFGFによる大脳皮質神経上皮細胞から大脳基底核原基神経上皮細胞への運命転換(Ventralizing effect of bFGF on cortical neuroepithelial cells) 神経化学. 2004.08; 43 (2-3): 397. ( ichushi )

  11. Namihira Masakazu, Nakashima Kinichi, Taga Tetsuya: Developmental stage dependent regulation of DNA methylation and chromatin modification in a immature astrocyte specific gene promoter. FEBS Lett. 2004.08; 572 (1-3): 184-188. ( PubMed , DOI )

  12. 落合 和, 滝沢 琢己, 中島 欽一, 田賀 哲也: 胎生期脳におけるAINTの役割(Role of AINT in the developing brain) 神経化学. 2004.08; 43 (2-3): 396. ( ichushi )

  13. 波平 昌一, 中島 欽一, 田賀 哲也: エピジェネティクス制御による中枢神経幹細胞のアストロサイト分化制御機構(Developmental stage dependent regulation of epigenetic modification of a premature astrocytic gene promoter) 神経化学. 2004.08; 43 (2-3): 396. ( ichushi )

  14. K Reif, K Okkenhaug, T Sasaki, JM Penninger, B Vanhaesebroeck, JG Cyster: Cutting edge: Differential roles for phosphoinositide 3-kinases, p110 gamma and p110 delta, in lymphocyte chemotaxis and homing JOURNAL OF IMMUNOLOGY. 2004.08; 173 (4): 2236-2240. ( PubMed , DOI )

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  16. Yasuo Horie, Akira Suzuki, Ei Kataoka, Takehiko Sasaki, Koichi Hamada, Junko Sasaki, Katsunori Mizuno, Go Hasegawa, Hiroyuki Kishimoto, Masahiro Iizuka, Makoto Naito, Katsuhiko Enomoto, Sumio Watanabe, Tak Wah Mak, Toru Nakano: Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J. Clin. Invest.. 2004.06; 113 (12): 1774-1783. ( PubMed , DOI )

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  21. Nobuhisa Ikuo, Kato Reiko, Inoue Hirofumi, Takizawa Makiko, Okita Keisuke, Yoshimura Akihiko, Taga Tetsuya: Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation. J Exp Med. 2004.03; 199 (5): 737-742. ( PubMed , DOI )

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  26. Inoue Hirofumi, Nobuhisa Ikuo, Okita Keisuke, Takizawa Makiko, Pebusque Marie Josephe, Taga Tetsuya: Negative regulation of hematopoiesis by the fused in myeloproliferative disorders gene product. Biochem Biophys Res Commun. 2004.01; 313 (1): 125-128. ( PubMed )

  1. Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K: Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. EMBO J. 2003.12; 22 (23): 6277-6288. ( PubMed , DOI )

  2. Nobuhisa Ikuo, Takizawa Makiko, Takaki Satoshi, Inoue Hirofumi, Okita Keisuke, Ueno Masaya, Takatsu Kiyoshi, Taga Tetsuya: Regulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor protein. Mol Cell Biol. 2003.12; 23 (23): 8486-8494. ( PubMed )

  3. S Giuriato, Pesesse, X, S Bodin, T Sasaki, C Viala, E Marion, J Penninger, S Schurmans, C Erneux, B Payrastre: SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels BIOCHEMICAL JOURNAL. 2003.11; 376 199-207. ( PubMed , DOI )

  4. Kwon Sangmo, Takizawa Hitoshi, Nobuhisa Ikuo, Taga Tetsuya, Takatsu Kiyoshi, Takaki Satoshi: Lnkアダプター蛋白はVav2/Rac/Pak経路の活性化を介してサイトカイン受容体媒介性アクチン再構成を制御する(Lnk adaptor protein regulates cytokine receptor-mediated actin reorganization by activating Vav2/Rac/PAK pathways) 日本免疫学会総会・学術集会記録. 2003.11; 33 259. ( ichushi )

  5. Junko Irie-Sasaki, Takehiko Sasaki, Josef M Penninger: CD45 regulated signaling pathways. Curr Top Med Chem. 2003.11; 3 (7): 783-796. ( PubMed )

  6. Minna Woo, Razqallah Hakem, Caren Furlonger, Anne Hakem, Gordon S Duncan, Takehiko Sasaki, Denis Bouchard, Liwei Lu, Gillian E Wu, Christopher J Paige, Tak W Mak: Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity. Nat. Immunol.. 2003.10; 4 (10): 1016-1022. ( PubMed , DOI )

  7. Gavin Y Oudit, Michael A Crackower, Urs Eriksson, Renu Sarao, Ivona Kozieradzki, Takehiko Sasaki, Junko Irie-Sasaki, Dominica Gidrewicz, Vitalyi O Rybin, Teiji Wada, Susan F Steinberg, Peter H Backx, Josef M Penninger: Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation. 2003.10; 108 (17): 2147-2152. ( PubMed , DOI )

  8. Takizawa Takumi, Ochiai Wataru, Nakashima Kinichi, Taga Tetsuya: Enhanced gene activation by Notch and BMP signaling cross-talk. Nucleic Acids Res. 2003.10; 31 (19): 5723-5731. ( PubMed )

  9. 鹿川 哲史, 井上 俊洋, 荒木 喜美, 中平 英子, 池中 一裕, 田賀 哲也: 子宮内エレクトロポレーション法を応用した神経系細胞系譜の解析(A new strategy for brain cell fate mapping by in utero DNA electroporationA new strategy for brain cell fate mapping by in utero DNA electroporation) 神経化学. 2003.08; 42 (2-3): 339. ( ichushi )

  10. Yamada M, Ohkawara B, Ichimura N, Hyodo-Miura J, Urushiyama S, Shirakabe K, Shibuya H: Negative regulation of Wnt signalling by HMG2L1, a novel NLK-binding protein. Genes Cells. 2003.08; 8 (8): 677-684. ( PubMed )

  11. AH Kim, T Sasaki, MV Chao: JNK-interacting protein 1 promotes Akt1 activation JOURNAL OF BIOLOGICAL CHEMISTRY. 2003.08; 278 (32): 29830-29836. ( PubMed , DOI )

  12. Fukuda Shinji, Takizawa Takumi, Namihira Masakazu, Kondo Toru, Nakashima Kinichi, Taga Tetsuya: 細胞分化の分子的基礎　転写ネットワークの交差制御相互作用により支配されている発達中の脳における細胞運命の決定(Molecular basis of cell differentiation: Cell-fate determination in the developing brain governed by cross-regulatory interactions of transcriptional networks) 生化学. 2003.08; 75 (8): 712. ( ichushi )

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  15. Oishi I, Suzuki H, Onishi N, Takada R, Kani S, Ohkawara B, Koshida I, Suzuki K, Yamada G, Schwabe GC, Mundlos S, Shibuya H, Takada S, Minami Y: The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells. 2003.07; 8 (7): 645-654. ( PubMed )

  16. Shimozaki Koji, Nakashima Kinichi, Niwa Hitoshi, Taga Tetsuya: Involvement of Oct3/4 in the enhancement of neuronal differentiation of ES cells in neurogenesis-inducing cultures. Development. 2003.06; 130 (11): 2505-2512. ( PubMed )

  17. H Kishimoto, K Nakagawa, T Watanabe, D Kitagawa, H Momose, J Seo, G Nishitai, N Shimizu, S Ohata, S Tanemura, S Asaka, T Goto, H Fukushi, H Yoshida, A Suzuki, T Sasaki, T Wada, JM Penninger, H Nishina, T Katada: Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells JOURNAL OF BIOLOGICAL CHEMISTRY. 2003.05; 278 (19): 16595-16601. ( PubMed , DOI )

  18. Okita Keisuke, Nobuhisa Ikuo, Takizawa Makiko, Ueno Masaya, Kimura Naoki, Taga Tetsuya: Genomic organization and characterization of the mouse ELYS gene. Biochem Biophys Res Commun. 2003.05; 305 (2): 327-332. ( PubMed )

  19. Takizawa Makiko, Nobuhisa Ikuo, Igarashi Katsuhide, Ueno Masaya, Nakashima Kinichi, Kitamura Toshio, Taga Tetsuya: Requirement of gp130 signaling for the AGM hematopoiesis. Exp Hematol. 2003.04; 31 (4): 283-289. ( PubMed )

  20. Suzawa M, Takada I, Yanagisawa J, Ohtake F, Ogawa S, Yamauchi T, Kadowaki T, Takeuchi Y, Shibuya H, Gotoh Y, Matsumoto K, Kato S: Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade. Nat Cell Biol. 2003.03; 5 (3): 224-230. ( PubMed , DOI )

  21. A Suzuki, T Kaisho, M Ohishi, M Tsukio-Yamaguchi, T Tsubata, PA Koni, T Sasaki, TW Mak, T Nakano: Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination JOURNAL OF EXPERIMENTAL MEDICINE. 2003.03; 197 (5): 657-667. ( PubMed , DOI )

  22. M Nogami, M Yamazaki, H Watanabe, Y Okabayashi, Y Kido, M Kasuga, T Sasaki, T Maehama, Y Kanaho: Requirement of autophosphorylated tyrosine 992 of EGF receptor and its docking protein phospholipase C gamma l for membrane ruffle formation FEBS LETTERS. 2003.02; 536 (1-3): 71-76. ( PubMed , DOI )

  23. Ishitani T, Kishida S, Hyodo-Miura J, Ueno N, Yasuda J, Waterman M, Shibuya H, Moon RT, Ninomiya-Tsuji J, Matsumoto K: The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol. 2003.01; 23 (1): 131-139. ( PubMed )

  1. Nuclear translocation of Plk1 mediated by its bipartite nuclear localization signal 2002.12; 277 (50): 48884-48888. ( PubMed , DOI )

  2. Komatsu Y, Shibuya H, Takeda N, Ninomiya-Tsuji J, Yasui T, Miyado K, Sekimoto T, Ueno N, Matsumoto K, Yamada G: Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis. Mech Dev. 2002.12; 119 (2): 239-249. ( PubMed )

  3. N Ito, T Yokomizo, T Sasaki, H Kurosu, J Penninger, Y Kanaho, T Katada, K Hanaoka, T Shimizu: Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B-4-induced enzyme release JOURNAL OF BIOLOGICAL CHEMISTRY. 2002.11; 277 (47): 44898-44904. ( PubMed , DOI )

  4. 權 相模, 高木 智, 信久 幾夫, 田賀 哲也, 高津 聖志: 細胞内アダプター蛋白質Lnkによる細胞骨格系制御とその機能部位(Control of actin cytoskeleton by an intracellular adaptor protein,Lnk and its functional subdomains) 日本癌学会総会記事. 2002.10; 61回 266. ( ichushi )

  5. Michael A Crackower, Gavin Y Oudit, Ivona Kozieradzki, Renu Sarao, Hui Sun, Takehiko Sasaki, Emilio Hirsch, Akira Suzuki, Tetsuo Shioi, Junko Irie-Sasaki, Rajan Sah, Hai-Ying M Cheng, Vitalyi O Rybin, Giuseppe Lembo, Luigi Fratta, Antonio J Oliveira-dos-Santos, Jeffery L Benovic, C Ronald Kahn, Seigo Izumo, Susan F Steinberg, Matthias P Wymann, Peter H Backx, Josef M Penninger: Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell. 2002.09; 110 (6): 737-749. ( PubMed )

  6. Goto T., Wallingford J.B.(The first two authors contributed equally), Keller R., Harland R.M.: Cloning and expression of Xenopus Prickle, an orthologue of a Drosophila planar cell polarity gene. Mech. Dev.. 2002.08; 116 183-186. ( PubMed )

  7. Goto T. (corresponding author), Keller R.: The planar cell polarity gene strabismus regulates convergence and extension and neural fold closure in Xenopus. Dev. Biol.. 2002.07; 247 165-181. ( PubMed , DOI )

  8. Hatta Toshihisa, Moriyama Kenji, Nakashima Kinichi, Taga Tetsuya, Otani Hiroki: The Role of gp130 in cerebral cortical development: in vivo functional analysis in a mouse exo utero system. J Neurosci. 2002.07; 22 (13): 5516-5524. ( PubMed , DOI )

  9. Kenji Matsuno, Michio Ichimura, Takao Nakajima, Keiko Tahara, Shigeki Fujiwara, Hiroshi Kase, Junko Ushiki, Neill A Giese, Anjali Pandey, Robert M Scarborough, Nathalie A Lokker, Jin-Chen Yu, Junko Irie, Eiji Tsukuda, Shin-ichi Ide, Shoji Oda, Yuji Nomoto: Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 1. Synthesis, structure-activity relationship, and biological effects of a new class of quinazoline derivatives. J. Med. Chem.. 2002.07; 45 (14): 3057-3066. ( PubMed )

  10. Nakashima Kinichi, Taga Tetsuya: Mechanisms underlying cytokine-mediated cell-fate regulation in the nervous system. Mol Neurobiol. 2002.06; 25 (3): 233-244. ( PubMed , DOI )

  11. Taga Tetsuya, Takizawa Takumi, Nakashima Kinichi: 脳神経系細胞系譜決定とその可塑的変化の分子メカニズム　胎生期中枢神経系の細胞系譜制御に関わる細胞外来性シグナルと細胞内在性プログラム(Cell-external cues and cell-intrinsic programs regulating lineage-determination in the developing brain) 神経化学. 2002.06; 41 (3): 298. ( ichushi )

  12. Hyodo-Miura J, Urushiyama S, Nagai S, Nishita M, Ueno N, Shibuya H: Involvement of NLK and Sox11 in neural induction in Xenopus development. Genes Cells. 2002.05; 7 (5): 487-496. ( PubMed )

  13. M Yamazaki, H Miyazaki, H Watanabe, T Sasaki, T Maehama, MA Frohman, Y Kanaho: Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling JOURNAL OF BIOLOGICAL CHEMISTRY. 2002.05; 277 (19): 17226-17230. ( PubMed , DOI )

  14. Plk1 promotes nuclear translocation of human Cdc25C during prophase 2002.04; 3 (4): 341-348. ( PubMed , DOI )

  15. Takehiko Sasaki, Akira Suzuki, Junko Sasaki, Josef M Penninger: Phosphoinositide 3-kinases in immunity: lessons from knockout mice. J. Biochem.. 2002.04; 131 (4): 495-501. ( PubMed )

  16. Kimura Naoki, Takizawa Makiko, Okita Keisuke, Natori Osamu, Igarashi Katsuhide, Ueno Masaya, Nakashima Kin-ichi, Nobuhisa Ikuo, Taga Tetsuya: Identification of a novel transcription factor, ELYS, expressed predominantly in mouse foetal haematopoietic tissues. Genes Cells. 2002.04; 7 (4): 435-446. ( PubMed )

  17. Uemura Atsumi, Takizawa Takumi, Ochiai Wataru, Yanagisawa Makoto, Nakashima Kinichi, Taga Tetsuya: Cardiotrophin-like cytokine induces astrocyte differentiation of fetal neuroepithelial cells via activation of STAT3. Cytokine. 2002.04; 18 (1): 1-7. ( PubMed )

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  19. Connie Krawczyk, Antonio Oliveira-dos-Santos, Takehiko Sasaki, Emily Griffiths, Pamela S Ohashi, Scott Snapper, Fred Alt, Josef M Penninger: Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity. 2002.03; 16 (3): 331-343. ( PubMed )

  1. Yanagisawa M, Nakashima K, Takeda K, Ochiai W, Takizawa T, Ueno M, Takizawa M, Shibuya H, Taga T: Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7. Genes Cells. 2001.12; 6 (12): 1091-1099. ( PubMed )

  2. HK Yum, J Arcaroli, J Kupfner, R Shenkar, JM Penninger, T Sasaki, KY Yang, JS Park, E Abraham: Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury JOURNAL OF IMMUNOLOGY. 2001.12; 167 (11): 6601-6608. ( PubMed , DOI )

  3. Yanagisawa Makoto, Takizawa Takumi, Ochiai Wataru, Uemura Atsumi, Nakashima Kinichi, Taga Tetsuya: 神経上皮細胞の神経発生の骨形態形成蛋白による星細胞発生への変化(Fate alteration of neuroepithelial cells from neurogenesis to astrocytogenesis by bone morphogenetic proteins) Neuroscience Research. 2001.12; 41 (4): 391-396. ( ichushi )

  4. Yanagisawa M, Nakashima K, Takeda K, Ochiai W, Takizawa T, Ueno M, Takizawa M, Shibuya H, Taga T: Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7 GENES TO CELLS. 2001.12; 6 (12): 1091-1099.

  5. Takizawa T, Nakashima K, Namihira M, Ochiai W, Uemura A, Yanagisawa M, Fujita N, Nakao M, Taga T: DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. Dev Cell. 2001.12; 1 (6): 749-758. ( PubMed )

  6. Yanagisawa M, Takizawa T, Ochiai W, Uemura A, Nakashima K, Taga T: Fate alteration of neuroepithelial cells from neurogenesis to astrocytogenesis by bone morphogenetic proteins. Neurosci Res. 2001.12; 41 (4): 391-396. ( PubMed )

  7. T Sasaki, J Sasaki-Irie, J M Penninger: New insights into the transmembrane protein tyrosine phosphatase CD45. Int. J. Biochem. Cell Biol.. 2001.11; 33 (11): 1041-1046. ( PubMed )

  8. R Hirose, H Okumura, A Yoshimatsu, J Irie, Y Onoda, Y Nomoto, H Takai, T Ohno, M Ichimura: KF31327, a new potent and selective inhibitor of cyclic nucleotide phosphodiesterase 5. Eur. J. Pharmacol.. 2001.11; 431 (1): 17-24. ( PubMed )

  9. Shirakabe K, Terasawa K, Miyama K, Shibuya H, Nishida E: Regulation of the activity of the transcription factor Runx2 by two homeobox proteins, Msx2 and Dlx5. Genes Cells. 2001.10; 6 (10): 851-856. ( PubMed )

  10. Fujita Yoshihiko, Ito Hiroe, Iino Ryota, Taga Tetsuya, Kusumi Akihiro: インターロイキン6刺激後のGP130シグナル複合体とアクチンフィラメントの相互作用　単一フルオロフォア動画像(INTERACTION OF GP130 SIGNALING COMPLEX WITH ACTIN FILAMENT AFTER INTERLEUKIN-6 STIMULATION: ANALYSIS BY SINGLE FLUOROPHORE DYNAMIC IMAGING) Cell Structure and Function. 2001.10; 26 (5): 451. ( ichushi )

  11. 田賀 哲也, 滝沢 琢己, 柳澤 亮, 中島 欽一: サイトカインシグナルによる中枢神経系前駆細胞の系譜制御 神経化学. 2001.09; 40 (2-3): 246. ( ichushi )

  12. Ueno M, Igarashi K, Kimura N, Okita K, Takizawa M, Nobuhisa I, Kojima T, Kitamura T, Samulowitz U, Vestweber D, Shimomura T, Suda T, Nakashima K, Taga T: Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion. Biochem Biophys Res Commun. 2001.09; 287 (2): 501-506. ( PubMed , DOI )

  13. T Sasaki, T Wada, H Kishimoto, J Irie-Sasaki, G Matsumoto, T Goto, Z Yao, A Wakeham, T W Mak, A Suzuki, S K Cho, J C Zuniga-Pflucker, A J Oliveira-dos-Santos, T Katada, H Nishina, J M Penninger: The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells. J. Exp. Med.. 2001.09; 194 (6): 757-768. ( PubMed )

  14. Teiji Wada, Kentaro Nakagawa, Tomomi Watanabe, Gen Nishitai, Jungwon Seo, Hiroyuki Kishimoto, Daiju Kitagawa, Takehiko Sasaki, Josef M. Penninger, Hiroshi Nishina, Toshiaki Katada: Impaired synergistic activation of stress-activated protein kinase SAPK/ JNK in mouse embryonic stem cells lacking SEK1/MKK4: Different contribution of SEK2/MKK7 isoforms to the synergistic activation Journal of Biological Chemistry. 2001.08; 276 (33): 30892-30897. ( PubMed , DOI )

  15. Choi MW, Yamamoto K, Masuno H, Nakashima K, Taga T, Yamada S: Ligand recognition by the vitamin D receptor BIOORGANIC & MEDICINAL CHEMISTRY. 2001.07; 9 (7): 1721-1730.

  16. Sugawara K, Morita K, Ueno N, Shibuya H: BIP, a BRAM-interacting protein involved in TGF-beta signalling, regulates body length in Caenorhabditis elegans. Genes Cells. 2001.07; 6 (7): 599-606. ( PubMed )

  17. Choi M, Yamamoto K, Masuno H, Nakashima K, Taga T, Yamada S: Ligand recognition by the vitamin D receptor. Bioorganic & medicinal chemistry. 2001.07; 9 (7): 1721-30. ( PubMed , DOI )

  18. Ochiai W, Yanagisawa M, Takizawa T, Nakashima K, Taga T: Astrocyte differentiation of fetal neuroepithelial cells involving cardiotrophin-1-induced activation of STAT3. Cytokine. 2001.06; 14 (5): 264-271. ( PubMed , DOI )

  19. Nichols J, Chambers I, Taga T, Smith A: Physiological rationale for responsiveness of mouse embryonic stem cells to gp130 cytokines. Development. 2001.06; 128 (12): 2333-2339. ( PubMed )

  20. Ochiai W, Yanagisawa M, Takizawa T, Nakashima K, Taga T: Astrocyte differentiation of fetal neuroepithelial cells involving cardiotrophin-1-induced activation of STAT3 CYTOKINE. 2001.06; 14 (5): 264-271.

  21. J M Penninger, J Irie-Sasaki, T Sasaki, A J Oliveira-dos-Santos: CD45: new jobs for an old acquaintance. Nat. Immunol.. 2001.05; 2 (5): 389-396. ( PubMed , DOI )

  22. Ohnishi J, Ohnishi E, Jin M, Hirano W, Nakane D, Matsui H, Kimura A, Sawa H, Nakayama K, Shibuya H, Nagashima K, Takahashi T: Cloning and characterization of a rat ortholog of MMP-23 (matrix metalloproteinase-23), a unique type of membrane-anchored matrix metalloproteinase and conditioned switching of its expression during the ovarian follicular development. Mol Endocrinol. 2001.05; 15 (5): 747-764. ( PubMed )

  23. Morita K, Shimizu M, Shibuya H, Ueno N: A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta signaling. Proc Natl Acad Sci U S A. 2001.05; 98 (11): 6284-6288. ( PubMed , DOI )

  24. Goto T., Hasegawa K., Kinoshita T., Kubota H.Y.: A novel POZ/zinc finger protein, champignon, interferes with gastrulation movements in Xenopus. Dev. Dyn.. 2001.05; 221 14-25. ( PubMed , DOI )

  25. Nakashima K, Takizawa T, Ochiai W, Yanagisawa M, Hisatsune T, Nakafuku M, Miyazono K, Kishimoto T, Kageyama R, Taga T: BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis. Proc Natl Acad Sci U S A. 2001.05; 98 (10): 5868-5873. ( PubMed , DOI )

  26. A Suzuki, M T Yamaguchi, T Ohteki, T Sasaki, T Kaisho, Y Kimura, R Yoshida, A Wakeham, T Higuchi, M Fukumoto, T Tsubata, P S Ohashi, S Koyasu, J M Penninger, T Nakano, T W Mak: T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity. 2001.05; 14 (5): 523-534. ( PubMed )

  27. Nakashima K, Takitawa T, Ochiai W, Yanagisawa M, Hisatsune T, Nakafuku M, Miyazono K, Kishimoto T, Kageyama R, Taga T: BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001.05; 98 (10): 5868-5873.

  28. Noakes C.R., Goto T., Keller R., Periasamy A.: Does digital deconvolution improve two-photon microscopy in deep tissue imaging? Proc. SPIE. 2001.04; 4262 389-395. ( DOI )

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  30. Takizawa T, Yanagisawa M, Ochiai W, Yasukawa K, Ishiguro T, Nakashima K, Taga T: Directly linked soluble IL-6 receptor-IL-6 fusion protein induces astrocyte differentiation from neuroepithelial cells via activation of STAT3. Cytokine. 2001.03; 13 (5): 272-279. ( PubMed , DOI )

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  33. Masuda Y, Sasaki A, Shibuya H, Ueno N, Ikeda K, Watanabe K: Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function. J Biol Chem. 2001.02; 276 (7): 5331-5338. ( PubMed , DOI )

  34. C Bony, S Roche, U Shuichi, T Sasaki, M A Crackower, J Penninger, H Mano, M Pucéat: A specific role of phosphatidylinositol 3-kinase gamma. A regulation of autonomic Ca(2)+ oscillations in cardiac cells. J. Cell Biol.. 2001.02; 152 (4): 717-728. ( PubMed )

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  37. J Irie-Sasaki, T Sasaki, W Matsumoto, A Opavsky, M Cheng, G Welstead, E Griffiths, C Krawczyk, C D Richardson, K Aitken, N Iscove, G Koretzky, P Johnson, P Liu, D M Rothstein, J M Penninger: CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature. 2001.01; 409 (6818): 349-354. ( PubMed , DOI )

  38. S Clément, U Krause, F Desmedt, J F Tanti, J Behrends, X Pesesse, T Sasaki, J Penninger, M Doherty, W Malaisse, J E Dumont, Y Le Marchand-Brustel, C Erneux, L Hue, S Schurmans: The lipid phosphatase SHIP2 controls insulin sensitivity. Nature. 2001.01; 409 (6816): 92-97. ( PubMed , DOI )

  1. Kato Hiroaki, Chen Shi, Kiyama Hiroshi, Ikeda Ken, Kimura Naoki, Nakashima Kinichi, Taga Tetsuya: ニューロン発生時及び再生時に顕著に発現する,WDリピートを持つ新規遺伝子の同定 The Journal of Biochemistry. 2000.12; 128 (6): 923-932. ( ichushi )

  2. Kato H, Chen S, Kiyama H, Ikeda K, Kimura N, Nakashima K, Taga T: Identification of a novel WD repeat-containing gene predominantly expressed in developing and regenerating neurons. J Biochem. 2000.12; 128 (6): 923-932. ( PubMed )

  3. Kato H, Chen S, Kiyama H, Ikeda K, Kimura N, Nakashima K, Taga T: Identification of a novel WD repeat-containing gene predominantly expressed in developing and regenerating neurons JOURNAL OF BIOCHEMISTRY. 2000.12; 128 (6): 923-932.

  4. AJ Oliveira-dos-Santos, G Matsumoto, BE Snow, DL Bai, FP Houston, IQ Whishaw, S Mariathasan, T Sasaki, A Wakeham, PS Ohashi, JC Roder, CA Barnes, DP Siderovski, JM Penninger: Regulation of T cell activation, anxiety, and male aggression by RGS2 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000.10; 97 (22): 12272-12277. ( PubMed , DOI )

  5. Kojima N, Kinoshita T, Kamiya A, Nakamura K, Nakashima K, Taga T, Miyajima A: Cell density-dependent regulation of hepatic development by a gp130-independent pathway. Biochem Biophys Res Commun. 2000.10; 277 (1): 152-158. ( PubMed , DOI )

  6. C Krawczyk, K Bachmaier, T Sasaki, R G Jones, S B Snapper, D Bouchard, I Kozieradzki, P S Ohashi, F W Alt, J M Penninger: Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity. 2000.10; 13 (4): 463-473. ( PubMed )

  7. Kojima N, Kinoshita T, Kamiya A, Nakamura K, Nakashima K, Taga T, Miyajima A: Cell density-dependent regulation of hepatic development by a gp 130-independent pathway BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000.10; 277 (1): 152-158.

  8. Shin HI, Paola D, Bringhurst FR, Taga T, Suda T, Kronenberg H: gp130 is necessary for full PTH-induced osteoclastic differentiation and activation. JOURNAL OF BONE AND MINERAL RESEARCH. 2000.09; 15 S218.

  9. J E Fata, Y Y Kong, J Li, T Sasaki, J Irie-Sasaki, R A Moorehead, R Elliott, S Scully, E B Voura, D L Lacey, W J Boyle, R Khokha, J M Penninger: The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell. 2000.09; 103 (1): 41-50. ( PubMed )

  10. Ueno M, Kimura N, Nakashima K, Saito-Ohara F, Inazawa J, Taga T: Genomic organization, sequence and chromosomal localization of the mouse Tbr2 gene and a comparative study with Tbr1 GENE. 2000.08; 254 (1-2): 29-35.

  11. T Sasaki, J Irie-Sasaki, Y Horie, K Bachmaier, JE Fata, M Li, A Suzuki, D Bouchard, A Ho, M Redston, S Gallinger, R Khokha, TW Mak, PT Hawkins, L Stephens, SW Scherer, M Tsao, JM Penninger: Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)K gamma NATURE. 2000.08; 406 (6798): 897-902. ( PubMed , DOI )

  12. Hanafusa H, Masuyama N, Kusakabe M, Shibuya H, Nishida E: The TGF-beta family member derriere is involved in regulation of the establishment of left-right asymmetry. EMBO Rep. 2000.07; 1 (1): 32-39. ( PubMed , DOI )

  13. Tago K, Nakamura T, Nishita M, Hyodo J, Nagai S, Murata Y, Adachi S, Ohwada S, Morishita Y, Shibuya H, Akiyama T: Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. Genes Dev. 2000.07; 14 (14): 1741-1749. ( PubMed )

  14. Goto T. (corresponding author), Katada T., Kinoshita T., Kubota H.Y.: Expression and characterization of Xenopus type I collagen alpha 1 (COL1A1) during embryonic development. Dev. Growth Differ.. 2000.06; 42 249-256. ( PubMed )

  15. Kimura N, Matsuo R, Shibuya H, Nakashima K, Taga T: BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. J Biol Chem. 2000.06; 275 (23): 17647-17652. ( PubMed , DOI )

  16. Kimura N, Matsuo R, Shibuya H, Nakashima K, Taga T: BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6 JOURNAL OF BIOLOGICAL CHEMISTRY. 2000.06; 275 (23): 17647-17652.

  17. Takatsu Y, Nakamura M, Stapleton M, Danos MC, Matsumoto K, O'Connor MB, Shibuya H, Ueno N: TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development. Mol Cell Biol. 2000.05; 20 (9): 3015-3026. ( PubMed )

  18. Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K: TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol Cell. 2000.04; 5 (4): 649-658. ( PubMed )

  19. Yanagisawa M, Nakashima K, Arakawa H, Ikenaka K, Yoshida K, Kishimoto T, Hisatsune T, Taga T: Astrocyte differentiation of fetal neuroepithelial cells by interleukin-11 via activation of a common cytokine signal transducer, gp130, and a transcription factor, STAT3. J Neurochem. 2000.04; 74 (4): 1498-1504. ( PubMed )

  20. Yanagisawa M, Nakashima K, Arakawa H, Ikenaka K, Yoshida K, Kishimoto T, Hisatsune T, Taga T: Astrocyte differentiation of fetal neuroepithelial cells by interleukin-11 via activation of a common cytokine signal transducer, gp130, and a transcription factor, STAT3 JOURNAL OF NEUROCHEMISTRY. 2000.04; 74 (4): 1498-1504.

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  23. Nishita M, Hashimoto MK, Ogata S, Laurent MN, Ueno N, Shibuya H, Cho KW: Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer. Nature. 2000.02; 403 (6771): 781-785. ( PubMed , DOI )

  24. Yamamoto K, Masuno H, Choi M, Nakashima K, Taga T, Ooizumi H, Umesono K, Sicinska W, VanHooke J, DeLuca H F, Yamada S: Three-dimensional modeling of and ligand docking to vitamin D receptor ligand binding domain. Proc Natl Acad Sci U S A. 2000.02; 97 (4): 1467-1472. ( PubMed , DOI )

  25. Yamamoto K, Masuno H, Choi M, Nakashima K, Taga T, Ooizumi H, Umesono K, Sicinska W, VanHooke J, DeLuca HF, Yamada S: Three-dimensional modeling of and ligand docking to vitamin D receptor ligand binding domain PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000.02; 97 (4): 1467-1472.

  26. K Bachmaier, C Krawczyk, I Kozieradzki, Y Y Kong, T Sasaki, A Oliveira-dos-Santos, S Mariathasan, D Bouchard, A Wakeham, A Itie, J Le, P S Ohashi, I Sarosi, H Nishina, S Lipkowitz, J M Penninger: Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 2000.01; 403 (6766): 211-216. ( PubMed , DOI )

  1. Barasch J, Yang J, Ware CB, Taga T, Yoshida K, Erdjument-Bromage H, Tempst P, Parravicini E, Malach S, Aranoff T, Oliver JA: Mesenchymal to epithelial conversion in rat metanephros is induced by LIF. Cell. 1999.11; 99 (4): 377-386. ( PubMed )

  2. Barasch J, Yang J, Ware CB, Taga T, Yoshida K, Erdjument-Bromage H, Tempst P, Parravicini E, Malach S, Aranoff T, Oliver JA: Mesenchymal to epithelial conversion in rat metanephros is induced by LIF CELL. 1999.11; 99 (4): 377-386.

  3. Nishita M, Ueno N, Shibuya H: Smad8B, a Smad8 splice variant lacking the SSXS site that inhibits Smad8-mediated signalling. Genes Cells. 1999.10; 4 (10): 583-591. ( PubMed )

  4. Shin HI, Divieti P, Kobayashi T, Chung U, Taga T, Suda T, Bringhurst RF, Kronenberg H: gp130 deficiency results in fetal hypocalcemia with increased blood serum PTH level. JOURNAL OF BONE AND MINERAL RESEARCH. 1999.09; 14 S197.

  5. Hanafusa H, Ninomiya-Tsuji J, Masuyama N, Nishita M, Fujisawa J, Shibuya H, Matsumoto K, Nishida E: Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression. J Biol Chem. 1999.09; 274 (38): 27161-27167. ( PubMed )

  6. Nakashima K, Yanagisawa M, Arakawa H, Taga T: Astrocyte differentiation mediated by LIF in cooperation with BMP2 FEBS LETTERS. 1999.08; 457 (1): 43-46.

  7. Nakashima K, Yanagisawa M, Arakawa H, Taga T: Astrocyte differentiation mediated by LIF in cooperation with BMP2. FEBS letters. 1999.08; 457 (1): 43-6. ( PubMed , DOI )

  8. Kimura N, Ueno M, Nakashima K, Taga T: A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains JOURNAL OF BIOCHEMISTRY. 1999.07; 126 (1): 180-187.

  9. Yanagisawa M, Nakashima K, Taga T: STAT3-mediated astrocyte differentiation from mouse fetal neuroepithelial cells by mouse oncostatin M NEUROSCIENCE LETTERS. 1999.07; 269 (3): 169-172.

  10. H Watanabe, M Miura, T Sasaki: Differential effects of the insulin-like growth factor I receptor on radiosensitivity and spontaneous necrosis formation of human glioblastoma cells grown in multicellular spheroids EXPERIMENTAL CELL RESEARCH. 1999.07; 250 (1): 99-111.

  11. Kimura N, Ueno M, Nakashima K, Taga T: A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains. Journal of biochemistry. 1999.07; 126 (1): 180-7. ( PubMed , DOI )

  12. Nakashima K, Wiese S, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Yoshida K, Kishimoto T, Sendtner M, Taga T: Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation. J Neurosci. 1999.07; 19 (13): 5429-5434. ( PubMed )

  13. Kimura Naoki, Ueno Masaya, Nakashima Kinich, Taga Tetsuya: 脳領域特異的遺伝子産物Lhx6.1はTandem LIM-domainsを介してLdb1を相互作用する The Journal of Biochemistry. 1999.07; 126 (1): 180-187. ( ichushi )

  14. Nakashima K, Wiese S, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Yoshida K, Kishimoto T, Sendtner M, Taga T: Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation JOURNAL OF NEUROSCIENCE. 1999.07; 19 (13): 5429-5434.

  15. Kimura N, Nakashima K, Ueno M, Kiyama H, Taga T: A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain DEVELOPMENTAL BRAIN RESEARCH. 1999.06; 115 (2): 183-193.

  16. Ishitani T, Ninomiya-Tsuji J, Nagai S, Nishita M, Meneghini M, Barker N, Waterman M, Bowerman B, Clevers H, Shibuya H, Matsumoto K: The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF. Nature. 1999.06; 399 (6738): 798-802. ( PubMed , DOI )

  17. Kimura N, Nakashima K, Ueno M, Kiyama H, Taga T: A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain. Brain research. Developmental brain research. 1999.06; 115 (2): 183-93. ( PubMed , DOI )

  18. JM Penninger, KD Fischer, T Sasaki, Kozieradzki, I, J Le, K Tedford, K Bachmaier, PS Ohashi, MF Bachmann: The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation EUROPEAN JOURNAL OF IMMUNOLOGY. 1999.05; 29 (5): 1709-1718. ( PubMed , DOI )

  19. Kamiya A, Kinoshita T, Ito Y, Matsui T, Morikawa Y, Senba E, Nakashima K, Taga T, Yoshida K, Kishimoto T, Miyajima A: Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer EMBO JOURNAL. 1999.04; 18 (8): 2127-2136.

  20. Miyama K, Yamada G, Yamamoto TS, Takagi C, Miyado K, Sakai M, Ueno N, Shibuya H: A BMP-inducible gene, dlx5, regulates osteoblast differentiation and mesoderm induction. Dev Biol. 1999.04; 208 (1): 123-133. ( PubMed , DOI )

  21. Masuyama N, Hanafusa H, Kusakabe M, Shibuya H, Nishida E: Identification of two Smad4 proteins in Xenopus. Their common and distinct properties. J Biol Chem. 1999.04; 274 (17): 12163-12170. ( PubMed )

  22. MA Lomaga, WC Yeh, Sarosi, I, GS Duncan, C Furlonger, A Ho, S Morony, C Capparelli, G Van, S Kaufman, A van der Heiden, A Itie, A Wakeham, W Khoo, T Sasaki, ZD Cao, JM Penninger, CJ Paige, DL Lacey, CR Dunstan, WJ Boyle, DV Goeddel, TW Mak: TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling GENES & DEVELOPMENT. 1999.04; 13 (8): 1015-1024. ( PubMed , DOI )

  23. Nakashima K, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Kawabata M, Miyazono K, Taga T: Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science. 1999.04; 284 (5413): 479-482. ( PubMed )

  24. Q Liu, T Sasaki, I Kozieradzki, A Wakeham, A Itie, D J Dumont, J M Penninger: SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival. Genes Dev.. 1999.04; 13 (7): 786-791. ( PubMed )

  25. Nakashima K, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Kawabata M, Miyazono K, Taga T: Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300 SCIENCE. 1999.04; 284 (5413): 479-482.

  26. Goto T., Kinoshita T.: Maternal transcripts of mitotic checkpoint gene, Xbub3, are accumulated in the animal blastomeres of Xenopus early embryo. DNA Cell Biol.. 1999.03; 18 227-234. ( PubMed , DOI )

  27. Hamada F, Tomoyasu Y, Takatsu Y, Nakamura M, Nagai S, Suzuki A, Fujita F, Shibuya H, Toyoshima K, Ueno N, Akiyama T: Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin. Science. 1999.03; 283 (5408): 1739-1742. ( PubMed )

  28. A Hakem, T Sasaki, I Kozieradzki, J M Penninger: The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis. J. Exp. Med.. 1999.03; 189 (6): 957-968. ( PubMed )

  29. H Nishina, C Vaz, P Billia, M Nghiem, T Sasaki, JL De la Pompa, K Furlonger, C Paige, CC Hui, KD Fischer, H Kishimoto, T Iwatsubo, T Katada, Woodgett, JR, JM Penninger: Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4 DEVELOPMENT. 1999.02; 126 (3): 505-516. ( PubMed )

  30. Yamaguchi K, Nagai S, Ninomiya-Tsuji J, Nishita M, Tamai K, Irie K, Ueno N, Nishida E, Shibuya H, Matsumoto K: XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway. EMBO J. 1999.01; 18 (1): 179-187. ( PubMed , DOI )

  1. van der Meijden M, Gage J, Breen EC, Taga T, Kishimoto T, Martinez-Maza O: IL-6 receptor (CD126 ' IL-6R ') expression is increased on monocytes and B lymphocytes in HIV infection CELLULAR IMMUNOLOGY. 1998.12; 190 (2): 156-166.

  2. Betz UAK, Bloch W, van den Broek M, Yoshida K, Taga T, Kishimoto T, Addicks K, Rajewsky K, Muller W: Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects JOURNAL OF EXPERIMENTAL MEDICINE. 1998.11; 188 (10): 1955-1965.

  3. Dani C, Chambers I, Johnstone S, Robertson M, Ebrahimi B, Saito M, Taga T, Li M, Burdon T, Nichols J, Smith A: Paracrine induction of stem cell renewal by LIF-deficient cells: A new ES cell regulatory pathway DEVELOPMENTAL BIOLOGY. 1998.11; 203 (1): 149-162.

  4. T Sasaki, T Maehama, T Yamamoto, S Takasuga, S Hoshino, H Nishina, O Hazeki, T Katada: Activation of c-Jun N-terminal kinase (JNK) by lysophosphatidic acid in Swiss 3T3 fibroblasts JOURNAL OF BIOCHEMISTRY. 1998.11; 124 (5): 934-939. ( PubMed , DOI )

  5. H Nishina, L Radvanyi, K Raju, T Sasaki, Kozieradzki, I, JM Penninger: Impaired TCR-mediated apoptosis and Bcl-XL expression in T cells lacking the stress kinase activator SEK1/MKK4 JOURNAL OF IMMUNOLOGY. 1998.10; 161 (7): 3416-3420. ( PubMed )

  6. V Stambolic, A Suzuki, J L de la Pompa, G M Brothers, C Mirtsos, T Sasaki, J Ruland, J M Penninger, D P Siderovski, T W Mak: Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell. 1998.10; 95 (1): 29-39. ( PubMed )

  7. Nakashima K, Taga T: gp130 and the IL-6 family of cytokines: Signaling mechanisms and thrombopoietic activities SEMINARS IN HEMATOLOGY. 1998.07; 35 (3): 210-221.

  8. Nakashima K, Taga T: gp130 and the IL-6 family of cytokines: signaling mechanisms and thrombopoietic activities. Seminars in hematology. 1998.07; 35 (3): 210-21. ( PubMed )

  9. Wang XJ, Taga T, Yoshida K, Saito M, Kishimoto T, Kikutani H: gp130, the cytokine common signal-transducer of interleukin-6 cytokine family, is downregulated in T cells in vivo by interleukin-6 BLOOD. 1998.05; 91 (9): 3308-3314.

  10. Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G(2) checkpoint 1998.05; 17 (10): 2728-2735. ( PubMed , DOI )

  11. KD Fischer, YY Kong, H Nishina, K Tedford, LEM Marengere, Kozieradzki, I, T Sasaki, M Starr, G Chan, S Gardener, MP Nghiem, D Bouchard, M Barbacid, A Bernstein, JM Penninger: Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor CURRENT BIOLOGY. 1998.05; 8 (10): 554-562. ( PubMed , DOI )

  12. Nyui N, Tamura K, Mizuno K, Ishigami T, Kihara M, Ochiai H, Kimura K, Umemura S, Ohno S, Taga T, Ishii M: Gp130 is involved in stretch-induced MAP kinase activation in cardiac myocytes BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1998.04; 245 (3): 928-932.

  13. Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H: BRAM1, a BMP receptor-associated molecule involved in BMP signalling. Genes Cells. 1998.04; 3 (4): 257-264. ( PubMed )

  14. Shibuya H, Iwata H, Masuyama N, Gotoh Y, Yamaguchi K, Irie K, Matsumoto K, Nishida E, Ueno N: Role of TAK1 and TAB1 in BMP signaling in early Xenopus development. EMBO J. 1998.02; 17 (4): 1019-1028. ( PubMed , DOI )

  1. Kimura T, Sakabe H, Tanimukai S, Abe T, Urata Y, Yasukawa K, Okano A, Taga T, Sugiyama H, Kishimoto T, Sonoda Y: Simultaneous activation of signals through gp130, c-kit, and interleukin-3 receptor promotes a trilineage blood cell production in the absence of terminally acting lineage-specific factors BLOOD. 1997.12; 90 (12): 4767-4778.

  2. A novel SAPK/JNK kinase, MKK7, stimulated by TNF alpha and cellular stresses 1997.12; 16 (23): 7045-7053. ( PubMed , DOI )

  3. ZB Yao, K Diener, XS Wang, M Zukowski, G Matsumoto, GS Zhou, R Mo, T Sasaki, H Nishina, CC Hui, TH Tan, JP Woodgett, JM Penninger: Activation of stress-activated protein kinases c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase (MKK7) JOURNAL OF BIOLOGICAL CHEMISTRY. 1997.12; 272 (51): 32378-32383. ( PubMed , DOI )

  4. Fas induces cytoplasmic apoptotic responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases 1997.11; 139 (4): 1005-1015. ( PubMed , DOI )

  5. Gotou T., Kinoshita K., Kinoshita T.: Calcium ionophore affecting the invagination in early Xenopus development. Kwansei Gakuin University Natural Sciences Reviews. 1997.10; 2 35-48.

  6. Akiyama S, Katagiri T, Namiki M, Yamaji N, Yamamoto N, Miyama K, Shibuya H, Ueno N, Wozney JM, Suda T: Constitutively active BMP type I receptors transduce BMP-2 signals without the ligand in C2C12 myoblasts. Exp Cell Res. 1997.09; 235 (2): 362-369. ( PubMed , DOI )

  7. Botchkareya NV, Botchkarev VA, Taga T, Paus R: Ciliary neurotrophic factor, interleukin-6 and their signal transducing receptor component gp130 in murine skin: Expression changes during hair follicle morphogenesis and cycling JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1997.09; 109 (3): 440.

  8. Naka T, Narazaki M, Hirata M, Matsumoto T, Minamoto S, Aono A, Nishimoto N, Kajita T, Taga T, Yoshizaki K, Akira S, Kishimoto T: Structure and function of a new STAT-induced STAT inhibitor. Nature. 1997.06; 387 (6636): 924-929. ( PubMed , DOI )

  9. Naka T, Narazaki M, Hirata M, Matsumoto T, Minamoto S, Aono A, Nishimoto N, Kajita T, Taga T, Yoshizaki K, Akira S, Kishimoto T: Structure and function of a new STAT-induced STAT inhibitor NATURE. 1997.06; 387 (6636): 924-929.

  10. Shirakabe K, Yamaguchi K, Shibuya H, Irie K, Matsuda S, Moriguchi T, Gotoh Y, Matsumoto K, Nishida E: TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase. J Biol Chem. 1997.03; 272 (13): 8141-8144. ( PubMed )

  11. Nakashima K, Narazaki M, Taga T: Leptin receptor (OB-R) oligomerizes with itself but not with its closely related cytokine signal transducer gp130 FEBS LETTERS. 1997.02; 403 (1): 79-82.

  12. Taga T: The signal transducer gp130 is shared by interleukin-6 family of haematopoietic and neurotrophic cytokines ANNALS OF MEDICINE. 1997.02; 29 (1): 63-72.

  13. Nakashima K, Narazaki M, Taga T: Overlapping and distinct signals through leptin receptor (OB-R) and a closely related cytokine signal transducer, gp130 FEBS LETTERS. 1997.01; 401 (1): 49-52.

  14. Taga T, Kishimoto T: Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol. 1997; 15 797-819. ( PubMed , DOI )

  1. Purification and identification of a major activator for p38 from osmotically shocked cells - Activation of mitogen-activated protein kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2 1996.10; 271 (43): 26981-26988. ( PubMed , DOI )

  2. Taga T: Gp130, a shared signal transducing receptor component for hematopoietic and neuropoietic cytokines. J Neurochem. 1996.07; 67 (1): 1-10. ( PubMed )

  3. Moriguchi T, Kuroyanagi N, Yamaguchi K, Gotoh Y, Irie K, Kano T, Shirakabe K, Muro Y, Shibuya H, Matsumoto K, Nishida E, Hagiwara M: A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J Biol Chem. 1996.06; 271 (23): 13675-13679. ( PubMed )

  4. Hirota H, Kiyama H, Kishimoto T, Taga T: Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma. J Exp Med. 1996.06; 183 (6): 2627-2634. ( PubMed )

  5. T Sasaki, K Hazeki, O Hazeki, M Ui, T Katada: Focal adhesion kinase (p125(FAK)) and paxillin are substrates for sphingomyelinase-induced tyrosine phosphorylation in Swiss 3T3 fibroblasts BIOCHEMICAL JOURNAL. 1996.05; 315 1035-1040. ( PubMed , DOI )

  6. Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, Irie K, Nishida E, Matsumoto K: TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science. 1996.05; 272 (5265): 1179-1182. ( PubMed )

  1. Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, Taniguchi T, Nishida E, Matsumoto K: Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science. 1995.12; 270 (5244): 2008-2011. ( PubMed )

  2. T SASAKI, K HAZEKI, O HAZEKI, M UL, T KATADA: PERMISSIVE EFFECT OF CERAMIDE ON GROWTH FACTOR-INDUCED CELL-PROLIFERATION BIOCHEMICAL JOURNAL. 1995.11; 311 829-834. ( PubMed , DOI )

  3. Hirota H, Yoshida K, Kishimoto T, Taga T: Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice. Proc Natl Acad Sci USA. 1995.05; 92 (11): 4862-4866. ( PubMed )

  1. Shibuya H, Kohu K, Yamada K, Barsoumian EL, Perlmutter RM, Taniguchi T: Functional dissection of p56lck, a protein tyrosine kinase which mediates interleukin-2-induced activation of the c-fos gene. Mol Cell Biol. 1994.09; 14 (9): 5812-5819. ( PubMed )

  2. Narazaki M, Witthuhn BA, Yoshida K, Silvennoinen O, Yasukawa K, Ihle JN, Kishimoto T, Taga T: Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130. Proc Natl Acad Sci USA. 1994.03; 91 (6): 2285-2289. ( PubMed )

  3. Kishimoto T, Taga T, Akira S: Cytokine signal transduction. Cell. 1994.01; 76 (2): 253-262. ( PubMed )

  4. Lütticken C, Wegenka UM, Yuan J, Buschmann J, Schindler C, Ziemiecki A, Harpur AG, Wilks AF, Yasukawa K, Taga T: Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. Science. 1994.01; 263 (5143): 89-92. ( PubMed )

  1. Murakami M, Hibi M, Nakagawa N, Nakagawa T, Yasukawa K, Yamanishi K, Taga T, Kishimoto T: IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science. 1993.06; 260 (5115): 1808-1810. ( PubMed )

  1. Taga T, Kishimoto T: Cytokine receptors and signal transduction. FASEB J. 1992.12; 6 (15): 3387-3396. ( PubMed )

  2. Taga T, Narazaki M, Yasukawa K, Saito T, Miki D, Hamaguchi M, Davis S, Shoyab M, Yancopoulos GD, Kishimoto T: Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130. Proc Natl Acad Sci USA. 1992.11; 89 (22): 10998-11001. ( PubMed )

  3. Kishimoto T, Akira S, Taga T: Interleukin-6 and its receptor: a paradigm for cytokines. Science. 1992.10; 258 (5082): 593-597. ( PubMed )

  4. Shibuya H, Yoneyama M, Ninomiya-Tsuji J, Matsumoto K, Taniguchi T: IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-myc. Cell. 1992.07; 70 (1): 57-67. ( PubMed )

  5. Shibuya H, Irie K, Ninomiya-Tsuji J, Goebl M, Taniguchi T, Matsumoto K: New human gene encoding a positive modulator of HIV Tat-mediated transactivation. Nature. 1992.06; 357 (6380): 700-702. ( PubMed , DOI )

  6. Hatakeyama M, Kawahara A, Mori H, Shibuya H, Taniguchi T: c-fos gene induction by interleukin 2: identification of the critical cytoplasmic regions within the interleukin 2 receptor beta chain. Proc Natl Acad Sci U S A. 1992.03; 89 (6): 2022-2026. ( PubMed )

  1. Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T: Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell. 1990.12; 63 (6): 1149-1157. ( PubMed )

  2. Shibuya H, Yoneyama M, Nakamura Y, Harada H, Hatakeyama M, Minamoto S, Kono T, Doi T, White R, Taniguchi T: The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignment. Nucleic Acids Res. 1990.07; 18 (13): 3697-3703. ( PubMed )

  1. Shibuya H, Taniguchi T: Identification of multiple cis-elements and trans-acting factors involved in the induced expression of human IL-2 gene. Nucleic Acids Res. 1989.11; 17 (22): 9173-9184. ( PubMed )

  2. Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, Hirano T, Kishimoto T: Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell. 1989.08; 58 (3): 573-581. ( PubMed )

  3. Shibuya H, Yoneyama M, Taniguchi T: Involvement of a common transcription factor in the regulated expression of IL-2 and IL-2 receptor genes. Int Immunol. 1989; 1 (1): 43-49. ( PubMed )

  4. Taga T, Hibi M, Hirata Y, Yawata H, Natsuka S, Yasukawa K, Totsuka T, Yamasaki K, Hirano T, Kishimoto T: Interleukin-6 receptor and a unique mechanism of its signal transduction. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 2 713-722. ( PubMed )

  1. Yamasaki Katsuhiko, Taga Tetsuya, Hirata Yuuichi: Interleukin 6receptorの分子構造 Proceedings of the Japan Academy Series B, Physical and Biological Sciences. 1988.09; 64 (7): 209-211. ( ichushi )

  2. Yamasaki K, Taga T, Hirata Y, Yawata H, Kawanishi Y, Seed B, Taniguchi T, Hirano T, Kishimoto T: Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. Science. 1988.08; 241 (4867): 825-828. ( PubMed )

  3. Kawano M, Hirano T, Matsuda T, Taga T, Horii Y, Iwato K, Asaoku H, Tang B, Tanabe O, Tanaka H: Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature. 1988.03; 332 (6159): 83-85. ( PubMed , DOI )

  1. Taga T, Kawanishi Y, Hardy RR, Hirano T, Kishimoto T: Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression. J Exp Med. 1987.10; 166 (4): 967-981. ( PubMed )

  2. Fujita T, Shibuya H, Hotta H, Yamanishi K, Taniguchi T: Interferon-beta gene regulation: tandemly repeated sequences of a synthetic 6 bp oligomer function as a virus-inducible enhancer. Cell. 1987.05; 49 (3): 357-367. ( PubMed )

  3. Maruyama M, Shibuya H, Harada H, Hatakeyama M, Seiki M, Fujita T, Inoue J, Yoshida M, Taniguchi T: Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering. Cell. 1987.01; 48 (2): 343-350. ( PubMed )

  4. Hirano T, Taga T, Yasukawa K, Nakajima K, Nakano N, Takatsuki F, Shimizu M, Murashima A, Tsunasawa S, Sakiyama F: Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production. Proc Natl Acad Sci USA. 1987.01; 84 (1): 228-231. ( PubMed )

  1. Fujita T, Shibuya H, Ohashi T, Yamanishi K, Taniguchi T: Regulation of human interleukin-2 gene: functional DNA sequences in the 5' flanking region for the gene expression in activated T lymphocytes. Cell. 1986.08; 46 (3): 401-405. ( PubMed )

  1. Hirano T, Taga T, Nakano N, Yasukawa K, Kashiwamura S, Shimizu K, Nakajima K, Pyun KH, Kishimoto T: Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). Proc Natl Acad Sci USA. 1985.08; 82 (16): 5490-5494. ( PubMed )

  1. Yugo Miyata,Katsumori Segawa, : Asymmetry and vulnerability on phospholipids in the plasma membrane 2023.04; 32 (2): 11-16. ( ichushi )

  1. Yugo Miyata, Kyoko Yamada, Shigekazu Nagata, Katsumori Segawa: Two types of type IV P-type ATPases independently re-establish the asymmetrical distribution of phosphatidylserine in plasma membranes. The Journal of biological chemistry. 2022.11; 298 (11): 102527. ( PubMed , DOI )

  2. Sabina A. Kondratyeva, Taisiya A. Voronina, Alexander A. Nesmelov, Yugo Miyata, Shoko Tokumoto, Richard Cornette, Maria V. Vorontsova, Takahiro Kikawada, Oleg A. Gusev, Elena I. Shagimardanova: Intracellular Localization and Gene Expression Analysis Provides New Insights on LEA Proteins' Diversity in Anhydrobiotic Cell Line Biology. 2022.04; 11 (4): ( PubMed , DOI )

  3. Yuta Ryoden, Katsumori Segawa, Shigekazu Nagata: Requirement of Xk and Vps13a for the P2X7-mediated phospholipid scrambling and cell lysis in mouse T cells. Proceedings of the National Academy of Sciences of the United States of America. 2022.02; 119 (7): ( PubMed , DOI )

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  1. Katsumori Segawa, Atsuo Kikuchi, Tomoyasu Noji, Yuki Sugiura, Keita Hiraga, Chigure Suzuki, Kazuhiro Haginoya, Yasuko Kobayashi, Mitsuhiro Matsunaga, Yuki Ochiai, Kyoko Yamada, Takuo Nishimura, Shinya Iwasawa, Wataru Shoji, Fuminori Sugihara, Kohei Nishino, Hidetaka Kosako, Masahito Ikawa, Yasuo Uchiyama, Makoto Suematsu, Hiroshi Ishikita, Shigeo Kure, Shigekazu Nagata: A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes. The Journal of clinical investigation. 2021.09; 131 (18): ( PubMed , DOI )

  2. Shigekazu Nagata, Katsumori Segawa: Sensing and clearance of apoptotic cells. Current opinion in immunology. 2021.02; 68 1-8. ( PubMed , DOI )

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  4. Yuta Ryoden, Toshihiro Fujii, Katsumori Segawa, Shigekazu Nagata: Functional Expression of the P2X7 ATP Receptor Requires Eros. Journal of immunology (Baltimore, Md. : 1950). 2020.02; 204 (3): 559-568. ( PubMed , DOI )

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  1. Takuma Tsuji, Jinglei Cheng, Tsuyako Tatematsu, Aoi Ebata, Hiroki Kamikawa, Akikazu Fujita, Sayuri Gyobu, Katsumori Segawa, Hiroyuki Arai, Tomohiko Taguchi, Shigekazu Nagata, Toyoshi Fujimoto: Predominant localization of phosphatidylserine at the cytoplasmic leaflet of the ER, and its TMEM16K-dependent redistribution PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019.07; 116 (27): 13368-13373. ( PubMed , DOI )

  2. Chihiro Nishi, Yuichi Yanagihashi, Katsumori Segawa, Shigekazu Nagata: MERTK tyrosine kinase receptor together with TIM4 phosphatidylserine receptor mediates distinct signal transduction pathways for efferocytosis and cell proliferation. The Journal of biological chemistry. 2019.05; 294 (18): 7221-7230. ( PubMed , DOI )

  1. Katsumori Segawa, Yuichi Yanagihashi, Kyoko Yamada, Chigure Suzuki, Yasuo Uchiyama, Shigekazu Nagata: Phospholipid flippases enable precursor B cells to flee engulfment by macrophages. Proceedings of the National Academy of Sciences of the United States of America. 2018.11; 115 (48): 12212-12217. ( PubMed , DOI )

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  1. Yuichi Yanagihashi, Katsumori Segawa, Ryota Maeda, Yo-ichi Nabeshima, Shigekazu Nagata: Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017.08; 114 (33): 8800-8805. ( PubMed , DOI )

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