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Yukine Ishibashi, Mitsuru Naito, Yusuke Watanuki, Mao Hori, Satomi Ogura, Kaori Taniwaki, Masaru Cho, Ryosuke Komiya, Yuki Mochida, Kanjiro Miyata: Size-Dependent Glioblastoma Targeting by Polymeric Nanoruler with Prolonged Blood Circulation. Bioconjug Chem. 2024.08; 35 (8): 1154-1159. ( PubMed , DOI )

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Saed Abbasi, Miki Matsui-Masai, Fumihiko Yasui, Akimasa Hayashi, Theofilus A Tockary, Yuki Mochida, Shiro Akinaga, Michinori Kohara, Kazunori Kataoka, Satoshi Uchida: Carrier-free mRNA vaccine induces robust immunity against SARS-CoV-2 in mice and non-human primates without systemic reactogenicity. Molecular Therapy. 2024.05; 32 (5): 1266-1283. ( PubMed , DOI )

Pengwen Chen, Wenqian Yang, Yuki Mochida, Shangwei Li, Taehun Hong, Hiroaki Kinoh, Kazunori Kataoka, Horacio Cabral: Selective Intracellular Delivery of Antibodies in Cancer Cells with Nanocarriers Sensing Endo/Lysosomal Enzymatic Activity. Angewandte Chemie International Edition. 2024.04; 63 (14): e202317817. ( PubMed , DOI )

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Okunishi K, Kochi Y, Zhao M, Wang H, Nakagome K, Izumi T: Munc13-4 regulates asthma and obesity in mice by controlling functions of CD11c(+) antigen-presenting cells. Allergy. 2024.03; 79 (7): 1992-1995. ( PubMed , DOI )

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Riki Ishibashi, Ritsuko Maki, Fumiko Toyoshima: Gene targeting in adult organs using in vivo cleavable donor plasmids for CRISPR-Cas9 and CRISPR-Cas12a Scientific Reports. 2024.03; 14 (1): 7615. ( DOI )

Yamano K, Kinefuchi H, Kojima W: Mitochondrial lipid dynamics regulated by MITOL-mediated ubiquitination. Journal of biochemistry. 2024.03; 175 (3): 217-219. ( PubMed , DOI )

Homma H, Tanaka H, Fujita K, Okazawa H: Necrosis Links Neurodegeneration and Neuroinflammation in Neurodegenerative Disease. Int J Mol Sci. 2024.03; 25 (7): 3636. ( PubMed , DOI )

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Kamii Y, Hayashizaki K, Kanno T, Chiba A, Ikegami T, Saito M, Akeda Y, Ohteki T, Kubo M, Yoshida K, Kawakami K, Oishi K, Araya J, Kuwano K, Kronenberg M, Endo Y, Kinjo Y.: IL-27 regulates the differentiation of follicular helper NKT cells via metabolic adaptation of mitochondria. Proc Natl Acad Sci USA.. 2024.02; 121 e2313964121.

Ohara D, Takeuchi Y, Watanabe H, Lee Y, Mukoyama H, Ohteki T, Kondoh G, Hirota K.: Notch2 with retinoic acid license IL-23 expression by intestinal EpCAM+ DCIR2+ cDC2s in mice J Exp Med.. 2024.02; 221 e20230923.

Miki Suzuki, Yuki Mochida, Mao Hori, Akimasa Hayashi, Kazuko Toh, Theofilus A. Tockary, Xueying Liu, Victor Marx, Hidetomo Yokoo, Kanjiro Miyata, Makoto Oba, Satoshi Uchida: Poly(ethylene Glycol) (PEG)–OligoRNA Hybridization to mRNA Enables Fine‐Tuned Polyplex PEGylation for Spleen‐Targeted mRNA Delivery Small Science. 2024.02; ( DOI )

Lucas Mixich, Eger Boonstra, Keita Masuda, Shang-Wei Li, Yuki Nakashima, Fanlu Meng, Momoko Sakata, Tatsuro Goda, Satoshi Uchida, Horacio Cabral: Ionizable Polymeric Micelles with Phenylalanine Moieties Enhance Intracellular Delivery of Self-Replicating RNA for Long-Lasting Protein Expression In Vivo. Biomacromolecules. 2024.02; 25 (2): 1058-1067. ( PubMed , DOI )

Hidetomo Yokoo, Anjaneyulu Dirisala, Satoshi Uchida, Makoto Oba: Oligosarcosine Conjugation of Arginine-Rich Peptides Improves the Intracellular Delivery of Peptide/pDNA Complexes. ACS Biomaterials Science & Engineering. 2024.02; 10 (2): 890-896. ( PubMed , DOI )

Yum J, Aulia F, Kamiya K, Hori M, Qiao N, Kim BS, Naito M, Ogura S, Nagata T, Yokota T, Uchida S, Obika S, Kim HJ, Miyata K: Hydrophobicity Tuning of Cationic Polyaspartamide Derivatives for Enhanced Antisense Oligonucleotide Delivery. Bioconjugate chemistry. 2024.01; 35 (2): 125-131. ( PubMed , DOI )

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Cui M, Yamano K, Yamamoto K, Yamamoto-Imoto H, Minami S, Yamamoto T, Matsui S, Kaminishi T, Shima T, Ogura M, Tsuchiya M, Nishino K, Layden BT, Kato H, Ogawa H, Oki S, Okada Y, Isaka Y, Kosako H, Matsuda N, Yoshimori T, Nakamura S: HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence. Proceedings of the National Academy of Sciences of the United States of America. 2024.01; 121 (2): e2306454120. ( PubMed , DOI )

Yamano K, Sawada M, Kikuchi R, Nagataki K, Kojima W, Endo R, Kinefuchi H, Sugihara A, Fujino T, Watanabe A, Tanaka K, Hayashi G, Murakami H, Matsuda N: Optineurin provides a mitophagy contact site for TBK1 activation. The EMBO journal. 2024.01; 43 (5): 754-779. ( PubMed , DOI )

Kawasaki I, Sugiura K, Sasaki T, Matsuda N, Sato M, Sato K: MARC-3, a membrane-associated ubiquitin ligase, is required for fast polyspermy block in Caenorhabditis elegans. Nature communications. 2024.01; 15 (1): 792. ( PubMed , DOI )

Yuki S Tateishi, Tamasa Araki, Satoru Kawai, Shuhei Koide, Yuko Umeki, Takashi Imai, Yumiko Saito-Nakano, Masaki Kikuchi, Atsushi Iwama, Hajime Hisaeda, Cevayir Coban, Takeshi Annoura: Histone H3.3 variant plays a critical role on zygote-to-oocyst development in malaria parasites. Parasitology International. 2024.01; ( PubMed , DOI )

Yuki Mochida, Satoshi Uchida: mRNA vaccine designs for optimal adjuvanticity and delivery. RNA Biology. 2024.01; 21 (1): 1-27. ( PubMed , DOI )

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Shichen Chang, Satoru Torii, Jun Inamo, Kinya Ishikawa, Yuta Kochi, Shigeomi Shimizu: Uncovering the Localization and Function of a Novel Read-Through Transcript ' TOMM40-APOE' Cells. 2023.12; 13 (1): ( PubMed , DOI )

Satoshi Kozuki, Mio Kabata, Satoko Sakurai, Keiko Iwaisako, Tomomi Nishimura, Masakazu Toi, Takuya Yamamoto, Fumiko Toyoshima: Periportal hepatocyte proliferation at midgestation governs maternal glucose homeostasis in mice Communications Biology. 2023.12; 6 (1): 1226. ( DOI )

Ueda, MT: Retrotransposon-derived transcripts and their functions in immunity and disease GENES & GENETIC SYSTEMS. 2023.12; 98 (6): 305-319. ( PubMed , DOI )

Yamano K, Kinefuchi H, Kojima W: Mitochondrial quality control via organelle and protein degradation. Journal of biochemistry. 2023.12; ( PubMed , DOI )

Mwalilino L, Yamane M, Ishiguro KI, Usuki S, Endoh M, Niwa H: The role of Zfp352 in the regulation of transient expression of 2-cell specific genes in mouse embryonic stem cells. Genes to cells : devoted to molecular & cellular mechanisms. 2023.12; 28 (12): 831-844. ( PubMed , DOI )

Mengjiao Li, Tatsunori Nishimura, Yasuto Takeuchi, Tsunaki Hongu, Yuming Wang, Daisuke Shiokawa, Kang Wang, Haruka Hirose, Asako Sasahara, Masao Yano, Satoko Ishikawa, Masafumi Inokuchi, Tetsuo Ota, Masahiko Tanabe, Kei-Ichiro Tada, Tetsu Akiyama, Xi Cheng, Chia-Chi Liu, Toshinari Yamashita, Sumio Sugano, Yutaro Uchida, Tomoki Chiba, Hiroshi Asahara, Masahiro Nakagawa, Shinya Sato, Yohei Miyagi, Teppei Shimamura, Luis Augusto E Nagai, Akinori Kanai, Manami Katoh, Seitaro Nomura, Ryuichiro Nakato, Yutaka Suzuki, Arinobu Tojo, Dominic C Voon, Seishi Ogawa, Koji Okamoto, Theodoros Foukakis, Noriko Gotoh: FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters. J Clin Invest. 2023.11; 133 (22): ( PubMed , DOI )

Tsuyuzaki K, Ishii M, Nikaido I: Sctensor detects many-to-many cell-cell interactions from single cell RNA-sequencing data. BMC bioinformatics. 2023.11; 24 (1): 420. ( PubMed , DOI )

Yoshioka Y, Taniguchi JB, Homma H, Tamura T, Fujita K, Inotsume M, Tagawa K, Misawa K, Matsumoto N, Nakagawa M, Inoue H, Tanaka H, Okazawa H: AAV-mediated editing of PMP22 rescues Charcot-Marie-Tooth disease type 1A features in patient-derived iPS Schwann cells. Commun Med (Lond). 2023.11; 3 (1): 170. ( PubMed , DOI )

[Shiki Fujino,Norikatsu Miyoshi,Aya Ito,Rie Hayashi,Masayoshi Yasui,Chu Matsuda,Masayuki Ohue,Masafumi Horie,Shinichi Yachida,Jun Koseki,Teppei Shimamura,Tsuyoshi Hata,Takayuki Ogino,Hidekazu Takahashi,Mamoru Uemura,Tsunekazu Mizushima,Yuichiro Doki,Hidetoshi Eguchi]: Metastases and treatment-resistant lineages in patient-derived cancer cells of colorectal cancer 2023.11; 6 (1): 1191. ( PubMed , DOI )

Gall-Duncan T, Luo J, Jurkovic CM, Fischer LA, Fujita K, Deshmukh AL, Harding RJ, Tran S, Mehkary M, Li V, Leib DE, Chen R, Tanaka H, Mason AG, Lévesque D, Khan M, Razzaghi M, Prasolava T, Lanni S, Sato N, Caron MC, Panigrahi GB, Wang P, Lau R, Castel AL, Masson JY, Tippett L, Turner C, Spies M, La Spada AR, Campos EI, Curtis MA, Boisvert FM, Faull RLM, Davidson BL, Nakamori M, Okazawa H, Wold MS, Pearson CE: Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability. Cell. 2023.10; 186 (22): 4898-4919.e25. ( PubMed , DOI )

Kobayashi Y, Niida A, Nagayama S, Saeki K, Haeno H, Takahashi KK, Hayashi S, Ozato Y, Saito H, Hasegawa T, Nakamura H, Tobo T, Kitagawa A, Sato K, Shimizu D, Hirata H, Hisamatsu Y, Toshima T, Yonemura Y, Masuda T, Mizuno S, Kawazu M, Kohsaka S, Ueno T, Mano H, Ishihara S, Uemura M, Mori M, Doki Y, Eguchi H, Oshima M, Suzuki Y, Shibata T, Mimori K: Subclonal accumulation of immune escape mechanisms in microsatellite instability-high colorectal cancers. British journal of cancer. 2023.10; 129 (7): 1105-1118. ( PubMed , DOI )

Yasuyuki Shima, Henrik Skibbe, Yohei Sasagawa, Noriko Fujimori, Yoshimi Iwayama, Ayako Isomura-Matoba, Minoru Yano, Takumi Ichikawa, Itoshi Nikaido, Nobutaka Hattori, Tadafumi Kato: Distinctiveness and continuity in transcriptome and connectivity in the anterior-posterior axis of the paraventricular nucleus of the thalamus Cell Reports. 2023.10; 42 (10): ( DOI )

Masaki Kikuchi, Shohei Takase, Tsuyoshi Konuma, Kota Noritsugu, Saaya Sekine, Takahisa Ikegami, Akihiro Ito, Takashi Umehara: GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain. Proceedings of the National Academy of Sciences of the United States of America. 2023.10; 120 (43): e2304103120. ( PubMed , DOI )

Shima, Y; Skibbe, H; Sasagawa, Y; Fujimori, N; Iwayama, Y; Isomura-Matoba, A; Yano, M; Ichikawa, T; Nikaido, I; Hattori, N; Kato, T: Distinctiveness and continuity in transcriptome and connectivity in the anterior-posterior axis of the paraventricular nucleus of the thalamus CELL REPORTS. 2023.10; 42 (10): 113309. ( PubMed , DOI )

Pu J, Kofuji S, Okamoto-Uchida Y, Danzaki K, Yu R, Suzuki A, Kitajima S, Nishina H: Lethal Phenotype-Based Database Screening Identifies Ceramide as a Negative Regulator of Primitive Streak Formation. Stem cells (Dayton, Ohio). 2023.10; 41 (12): 1142-1156. ( PubMed , DOI )

[Miki Kato,Keisuke Maeda,Ryuichi Nakahara,Haruka Hirose,Ayano Kondo,Sho Aki,Maki Sugaya,Sana Hibino,Miyuki Nishida,Manami Hasegawa,Hinano Morita,Ritsuko Ando,Rika Tsuchida,Minoru Yoshida,Tatsuhiko Kodama,Hideyuki Yanai,Teppei Shimamura,Tsuyoshi Osawa]: Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils PNAS nexus. 2023.10; 2 (10): pgad306. ( PubMed , DOI )

[Ryuichi Nakahara,Sho Aki,Maki Sugaya,Haruka Hirose,Miki Kato,Keisuke Maeda,Daichi M Sakamoto,Yasuhiro Kojima,Miyuki Nishida,Ritsuko Ando,Masashi Muramatsu,Melvin Pan,Rika Tsuchida,Yoshihiro Matsumura,Hideyuki Yanai,Hiroshi Takano,Ryoji Yao,Shinsuke Sando,Masabumi Shibuya,Juro Sakai,Tatsuhiko Kodama,Hiroyasu Kidoya,Teppei Shimamura,Tsuyoshi Osawa]: Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth 2023.10; 42 (22): e114032. ( PubMed , DOI )

Chisato Ono, Shinya Tanaka, Keiko Myouzen, Takeshi Iwasaki, Mahoko Ueda, Yoshinao Oda, Kazuhiko Yamamoto, Yuta Kochi, Yoshihiro Baba: Upregulated Fcrl5 disrupts B cell anergy causes autoimmune disease Frontiers in Immunology. 2023.09; 14 276014. ( DOI )

Mahoko Takahashi Ueda: Retrotransposon-derived transcripts and their functions associated with immunity and disease Genes & Genetic Systems. 2023.09; in press

Yoshitaka Murota, Mariko Nagane, Mei Wu, Mithun Santra, Seshasailam Venkateswaran, Shinji Tanaka, Mark Bradley, Tetsuya Taga, Kouichi Tabu : A niche-mimicking polymer hydrogel-based approach to identify molecular targets for tackling human pancreatic cancer stem cells Inflammation and Regeneration. 2023.09; 43 (1): 46. ( PubMed , DOI )

Nishita M, Kamizaki K, Hoshi K, Aruga K, Nishikaku I, Shibuya H, Matsumoto K, Minami Y: Rho family small GTPase Rif regulates Wnt5a-Ror1-Dvl2 signaling and promotes lung adenocarcinoma progression. The Journal of biological chemistry. 2023.09; 299 (10): 105248. ( PubMed , DOI )

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Yoshitaka Murota, Kouichi Tabu, Tetsuya Taga: Cancer Stem Cell-Associated Immune Microenvironment in Recurrent Glioblastomas Cells. 2022.06; 11 (13): 2054.

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Aziz Awaad, Hiroyasu Takemoto, Muneaki Iizuka, Koichi Ogi, Yuki Mochida, Abdul-Hackam Ranneh, Masahiro Toyoda, Makoto Matsui, Takahiro Nomoto, Yuto Honda, Kotaro Hayashi, Keishiro Tomoda, Tomoyuki Ohtake, Yutaka Miura, Nobuhiro Nishiyama: Changeable net charge on nanoparticles facilitates intratumor accumulation and penetration. Journal of Controlled Release. 2022.06; 346 392-404. ( PubMed , DOI )

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Sinclear Caleb Kwame, Maruyama Junichi, Nagashima Shunta, Arimoto-Matsuzaki Kyoko, Kuleape Joshua Agbemefa, Iwasa Hiroaki, Nishina Hiroshi, Hata Yutaka: Protein kinase Cα activation switches YAP1 from TEAD-mediated signaling to p73-mediated signaling(和訳中) Cancer Science. 2022.04; 113 (4): 1305-1320. ( ichushi )

Caleb Kwame Sinclear, Junichi Maruyama, Shunta Nagashima, Kyoko Arimoto-Matsuzaki, Joshua Agbemefa Kuleape, Hiroaki Iwasa, Hiroshi Nishina, Yutaka Hata: Protein kinase Cα activation switches YAP1 from TEAD-mediated signaling to p73-mediated signaling. Cancer Sci. 2022.04; 113 (4): 1305-1320. ( PubMed , DOI )

Anjaneyulu Dirisala, Satoshi Uchida, Junjie Li, Joachim F. R. Van Guyse, Kotaro Hayashi, Sai V. C. Vummaleti, Sarandeep Kaur, Yuki Mochida, Shigeto Fukushima, Kazunori Kataoka: Effective mRNA Protection by Poly(l-ornithine) Synergizes with Endosomal Escape Functionality of a Charge-Conversion Polymer toward Maximizing mRNA Introduction Efficiency Macromolecular Rapid Communications. 2022.03; 43 (12): 2100754. ( DOI )

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Basu G, Hall D, Ito N: Special Issue call: Computational biophysics and structural biology of proteins-A Special Issue in honor of Prof. Haruki Nakamura's 70th birthday. Biophysical reviews. 2022.02; 14 (1): 21-22. ( PubMed , DOI )

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Oda Masayuki, Sano Tomoki, Kamatari Yuji O., Abe Yoshito, Ikura Teikichi, Ito Nobutoshi: Structural Analysis of Hen Egg Lysozyme Refolded after Denaturation at Acidic pH PROTEIN JOURNAL. 2022.02; 41 (1): 71-78. ( PubMed , DOI )

Yasuyuki Shima, Henrik Skibbe, Yohei Sasagawa, Noriko Fujimori, Itoshi Nikaido, Nobutaka Hattori, Tadafumi Kato: Distinctiveness and continuity in transcriptome and connectivity in the anterior-posterior axis of the paraventricular nucleus of thalamus bioRxiv (preprint). 2022.02; ( DOI )

Shimizu M, Shibuya H, Tanaka N: Enhanced O-GlcNAc modification induced by the RAS/MAPK/CDK1 pathway is required for SOX2 protein expression and generation of cancer stem cells. Scientific reports. 2022.02; 12 (1): 2910. ( PubMed , DOI )

Yasuhiro Nakagawa, Jeonggyu Lee, Yihua Liu, Saed Abbasi, Taehun Hong, Horacio Cabral, Satoshi Uchida, Mitsuhiro Ebara: Microglial Immunoregulation by Apoptotic Cellular Membrane Mimetic Polymeric Particles ACS Macro Letters. 2022.01; 11 (2): 270-275. ( DOI )

Shoko Miyata, Noriaki Saku, Saeko Akiyama, Palaksha Kanive Javaregowda, Kenta Ite, Nagisa Takashima, Masashi Toyoda, Kei Yura, Tohru Kimura, Hiroshi Nishina, Atsuko Nakazawa, Mureo Kasahara, Hidenori Nonaka, Tohru Kiyono, Akihiro Umezawa: Puromycin-based purification of cells with high expression of the cytochrome P450 CYP3A4 gene from a patient with drug-induced liver injury (DILI). Stem Cell Res Ther. 2022.01; 13 (1): 6. ( PubMed , DOI )

Fujioka Toshifumi, Numoto Nobutaka, Akama Hiroyuki, Shilpa Kola, Oka Michiko, Roy Prodip K., Krishna Yarkali, Ito Nobutoshi, Baker David, Oda Masayuki, Tanaka Fujie: Varying the Directionality of Protein Catalysts for Aldol and Retro-Aldol Reactions CHEMBIOCHEM. 2022.01; 23 (2): e202100435. ( PubMed , DOI )

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Morioka S, Nakanishi H, Yamamoto T, Hasegawa J, Tokuda E, Hikita T, Sakihara T, Kugii Y, Oneyama C, Yamazaki M, Suzuki A, Sasaki J, Sasaki T: A mass spectrometric method for in-depth profiling of phosphoinositide regioisomers and their disease-associated regulation. Nature communications. 2022.01; 13 (1): 83. ( PubMed , DOI )

Asami Kawasaki, Akiko Sakai, Hiroki Nakanishi, Junya Hasegawa, Tomohiko Taguchi, Junko Sasaki, Hiroyuki Arai, Takehiko Sasaki, Michihiro Igarashi, Fubito Nakatsu: PI4P/PS countertransport by ORP10 at ER-endosome membrane contact sites regulates endosome fission. J Cell Biol. 2022.01; 221 (1): ( PubMed , DOI )

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Honda S, Ikari K, Yano K, Terao C, Tanaka E, Harigai M, Kochi Y: Polygenic risk scores are associated with radiographic progression in patients with rheumatoid arthritis. Arthritis & rheumatology (Hoboken, N.J.). 2022.01; 74 (5): 791-800. ( PubMed , DOI )

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Yazan Alwarawrah, Keiko Danzaki, Amanda G Nichols, Brian E Fee, Cheryl Bock, Gary Kucera, Laura P Hale, Gregory A Taylor, Nancie J MacIver: Irgm1 regulates metabolism and function in T cell subsets. Scientific Reports. 2022.01; 12 (1): 850. ( PubMed , DOI )

Numoto Nobutaka, Onoda Seiko, Kawano Yoshiaki, Okumura Hideo, Baba Seiki, Fukumori Yoshihiro, Miki Kunio, Ito Nobutoshi: 400kDa V2ヘモグロビンの酸素解離中間体の構造は蛋白質アロステリーの粗スナップショットを提供する(Structures of oxygen dissociation intermediates of 400 kDa V2 hemoglobin provide coarse snapshots of the protein allostery) Biophysics and Physicobiology. 2022; 19 e190019_1-e190019_10. ( ichushi )

Kotake K, Kumazawa T, Nakamura K, Shimizu Y, Ayabe T, Adachi T: Ingestion of miso regulates immunological robustness in mice. PloS one. 2022; 17 (1): e0261680. ( PubMed , DOI )

Kotake K, Kumazawa T, Adachi T: Long-term administration of Tetragenococcus halophilus No. 1 over generations affects the immune system of mice. PloS one. 2022; 17 (4): e0267473. ( PubMed , DOI )

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Naoto Yoshinaga, Satoshi Uchida, Anjaneyulu Dirisala, Mitsuru Naito, Kyoko Koji, Kensuke Osada, Horacio Cabral, Kazunori Kataoka: Bridging mRNA and Polycation Using RNA Oligonucleotide Derivatives Improves the Robustness of Polyplex Micelles for Efficient mRNA Delivery Advanced Healthcare Materials. 2021.12; 11 (9): 2102016. ( DOI )

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Ikeda Yoshiki, Hirayama Akiyoshi, Kofuji Satoshi, Hirota Yoshihisa, Kamata Ryo, Osaka Natsuki, Fujii Yuki, Sasaki Mika, Ikeda Satsuki, Smith Eric P., Bachoo Robert, Soga Tomoyoshi, Sasaki Atsuo T.: SI-MOIRAI: a new method to identify and quantify the metabolic fate of nucleotides(和訳中) The Journal of Biochemistry. 2021.12; 170 (6): 699-711. ( ichushi )

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Okazawa H, Tanaka H: Molecular Dissection and Therapeutic Application of SCA1 Pathologies Revealed by Comprehensive Approaches. Cerebellum as a CNS Hub. 2021.11; 479-486.

Bruno Barros Queliconi, Waka Kojima, Mayumi Kimura, Kenichiro Imai, Chisato Udagawa, Chie Motono, Takatsugu Hirokawa, Shinya Tashiro, Jose M M Caaveiro, Kouhei Tsumoto, Koji Yamano, Keiji Tanaka, Noriyuki Matsuda: Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-1. J Cell Sci. 2021.11; 134 (22): jcs258653. ( PubMed , DOI )

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Fujioka Yoichiro, Satoh Aya O., Horiuchi Kosui, Fujioka Mari, Tsutsumi Kaori, Sasaki Junko, Nepal Prabha, Kashiwagi Sayaka, Paudel Sarad, Nishide Shinya, Nanbo Asuka, Sasaki Takehiko, Ohba Yusuke: A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection(和訳中) Cell Structure and Function. 2019.12; 44 (1-2): 61-74. ( ichushi )

Koyano F, Yamano K, Kosako H, Kimura Y, Kimura M, Fujiki Y, Tanaka K, Matsuda N: Parkin-mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes. EMBO reports. 2019.12; 20 (12): e47728. ( PubMed , DOI )

Hirotaka Matsumoto, Tetsutaro Hayashi, Haruka Ozaki, Koki Tsuyuzaki, Mana Umeda, Tsuyoshi Iida, Masaya Nakamura, Hideyuki Okano, Itoshi Nikaido: A NMF based approach to discover overlooked differentially expressed gene regions from single-cell RNA-seq NAR Genomics and Bioinformatics. 2019.12; 2 (1): lqz020.

Ichiro Fukunaga, Takahiro Shiga, Cheng Chen, Yoko Oe, Keiko Danzaki, Sayaka Ohta, Rina Matsuoka, Takashi Anzai, Remi Hibiya-Motegi, Shori Tajima, Katsuhisa Ikeda, Wado Akamatsu, Kazusaku Kamiya: Generation of the induced pluripotent stem cell (hiPSC) line (JUFMDOi004-A) from a patient with hearing loss carrying GJB2 (p.V37I) mutation. Stem Cell Research. 2019.12; 43 101674. ( PubMed , DOI )

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Kanayama Masashi, Izumi Yuta, Ohteki Toshiaki: Hematopoiesis and Immune Environment　Analysis with an alternative marker for Sca-1 revealed bona fide hematopoietic responses during infection(和訳中) 日本免疫学会総会・学術集会記録. 2019.11; 48 (Proceedings): 1-H. ( ichushi )

Fujita Kyota, Chen Xigui, Homma Hidenori, Tagawa Kazuhiko, Okazawa Hitoshi: Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology(和訳中) 臨床神経学. 2019.11; 59 (Suppl.): S213. ( ichushi )

Ono Chisato, Kochi Yuta, Tanaka Shinya, Yamamoto Kazuhiko, Baba Yoshihiro: Systemic lupus erythematosus and other systemic autoimmune diseases　Role of Fcrl5 in B cell immune response and peripheral tolerance(和訳中) 日本免疫学会総会・学術集会記録. 2019.11; 48 (Proceedings): 2-B. ( ichushi )

Nobuhisa Ikuo, Saito Kiyoka, Tsukahara Ryota, Azuma Koya, Melig Gerel, Itabashi Ayumi, Taga Tetsuya: Hematopoiesis and Immune Environment　Involvement of TET1 inthe maintenance of the hematopoietic capacity in hematopoietic cell clusters in the dorsal aorta in midgestation mouse embryo(和訳中) 日本免疫学会総会・学術集会記録. 2019.11; 48 (Proceedings): 1-H. ( ichushi )

Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia. 2019.10; 10 (1): 4869. ( PubMed , DOI )

Theofilus A. Tockary, Wanling Foo, Anjaneyulu Dirisala, Qixian Chen, Satoshi Uchida, Shigehito Osawa, Yuki Mochida, Xueying Liu, Hiroaki Kinoh, Horacio Cabral, Kensuke Osada, Kazunori Kataoka: Single-Stranded DNA-Packaged Polyplex Micelle as Adeno-Associated-Virus-Inspired Compact Vector to Systemically Target Stroma-Rich Pancreatic Cancer ACS Nano. 2019.10; 13 (11): 12732-12742. ( DOI )

Nishiguchi A, Numoto N, Ito N, Azuma T, Oda M: Three-dimensional structure of a high affinity anti-(4-hydroxy-3-nitrophenyl)acetyl antibody possessing a glycine residue at position 95 of the heavy chain. Molecular immunology. 2019.10; 114 545-552. ( PubMed , DOI )

Kunimoto Kayo, Honda-Ozaki Fumiko, Saito Megumu K., Furukawa Fukumi, Kanazawa Nobuo: 中條・西村症候群の小児症例に対するメトトレキサートの有益な作用(Beneficial effect of methotrexate on a child case of Nakajo-Nishimura syndrome) The Journal of Dermatology. 2019.10; 46 (10): e365-e367. ( ichushi )

Aoi H, Mizuguchi T, Ceroni JR, Kim VEH, Furquim I, Honjo RS, Iwaki T, Suzuki T, Sekiguchi F, Uchiyama Y, Azuma Y, Hamanaka K, Koshimizu E, Miyatake S, Mitsuhashi S, Takata A, Miyake N, Takeda S, Itakura A, Bertola DR, Kim CA, Matsumoto N: Comprehensive genetic analysis of 57 families with clinically suspected Cornelia de Lange syndrome. Journal of human genetics. 2019.10; 64 (10): 967-978. ( PubMed , DOI )

Kryukov K, Ueda MT, Nakagawa S, Imanishi T: Nucleotide Archival Format (NAF) enables efficient lossless reference-free compression of DNA sequences. Bioinformatics (Oxford, England). 2019.10; 35 (19): 3826-3828. ( PubMed , DOI )

Den K, Kudo Y, Kato M, Watanabe K, Doi H, Tanaka F, Oguni H, Miyatake S, Mizuguchi T, Takata A, Miyake N, Mitsuhashi S, Matsumoto N: Recurrent NUS1 canonical splice donor site mutation in two unrelated individuals with epilepsy, myoclonus, ataxia and scoliosis - a case report. BMC neurology. 2019.10; 19 (1): 253. ( PubMed , DOI )

Yoshikawa S, Oh-hora M, Hashimoto R, Miyake K, Adachi T, Kawano Y, Yamanishi Y, Kamiya A, Karasuyama H: Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated basophils EUROPEAN JOURNAL OF IMMUNOLOGY. 2019.10; 49 584-585.

Yoshikawa S., Oh-hora M., Hashimoto R., Miyake K., Adachi T., Kawano Y., Yamanishi Y., Kamiya A., Karasuyama H.: Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated basophils EUROPEAN JOURNAL OF IMMUNOLOGY. 2019.10; 49 584-585.

成田 伸太郎, 中西 広樹, 松田 芳教, 小泉 淳, 江口 賢史, 高須賀 俊輔, 黄 明国, 井上 高光, 佐々木 純子, 南条 博, 羽渕 友則, 佐々木 雄彦: 腎癌におけるイノシトールリン脂質発現プロファイル(The expression profile of phosphatidylinositol phosphates in clinical renal cell carcinoma) 日本癌学会総会記事. 2019.09; 78回 P-1154. ( ichushi )

Uchiyama Y, Kim CA, Pastorino AC, Ceroni J, Lima PP, de Barros Dorna M, Honjo RS, Bertola D, Hamanaka K, Fujita A, Mitsuhashi S, Miyatake S, Takata A, Miyake N, Mizuguchi T, Matsumoto N: Primary immunodeficiency with chronic enteropathy and developmental delay in a boy arising from a novel homozygous RIPK1 variant. Journal of human genetics. 2019.09; 64 (9): 955-960. ( PubMed , DOI )

McCormick Barry, Craig Helen E., Chu Julia Y., Carlin Leo M., Canel Marta, Wollweber Florian, Toivakka Matilda, Michael Melina, Astier Anne L., Norton Laura, Lilja Johanna, Felton Jennifer M., Sasaki Takehiko, Ivaska Johanna, Hers Ingeborg, Dransfield Ian, Rossi Adriano G., Vermeren Sonja: A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites JOURNAL OF IMMUNOLOGY. 2019.09; 203 (6): 1579-1588. ( PubMed , DOI )

Koizumi Atsushi, Narita Shintaro, Nakanishi Hiroki, Ishikawa Masaki, Eguchi Satoshi, Kimura Hirotaka, Takasuga Shunsuke, Huang Mingguo, Inoue Takamitsu, Sasaki Junko, Yoshioka Toshiaki, Habuchi Tomonori, Sasaki Takehiko: Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression SCIENTIFIC REPORTS. 2019.09; 9 (1): 13257. ( PubMed , DOI )

Saida K, Kim CA, Ceroni JRM, Bertola DR, Honjo RS, Mitsuhashi S, Takata A, Mizuguchi T, Miyatake S, Miyake N, Matsumoto N: Hemorrhagic stroke and renovascular hypertension with Grange syndrome arising from a novel pathogenic variant in YY1AP1. Journal of human genetics. 2019.09; 64 (9): 885-890. ( PubMed , DOI )

Naffouje R, Grover P, Yu H, Sendilnathan A, Wolfe K, Majd N, Smith EP, Takeuchi K, Senda T, Kofuji S, Sasaki AT: Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story. Cancers. 2019.09; 11 (9): ( PubMed , DOI )

Koizumi A, Narita S, Nakanishi H, Ishikawa M, Eguchi S, Kimura H, Takasuga S, Huang M, Inoue T, Sasaki J, Yoshioka T, Habuchi T & Sasaki T.: Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression. Sci Rep. 2019.09; 9 (1): 13257. ( DOI )

AIMAITIJIANG ALAPATI, 椨 康一, 田賀 哲也: グリオーマ幹細胞によるマウス骨髄赤芽球分化の促進(Glioma stem cells modulate erythropoiesis in mouse bone marrow) 日本癌学会総会記事. 2019.09; 78回 P-3065. ( ichushi )

椨 康一, 田賀 哲也: グリオーマの新規治療標的としての単球動員がん幹細胞の可視化と検証(Visualization and validation of monocyte-recruiting cells as a potential target of glioma stem cells) 日本癌学会総会記事. 2019.09; 78回 P-3064. ( ichushi )

Hiroyuki Tezuka, Toshiaki Ohteki: Regulation of IgA Production by Intestinal Dendritic Cells and Related Cells. Front Immunol. 2019.08; 10 1891. ( PubMed , DOI )

Masuno Hiroyuki, Kazui Yuko, Tanatani Aya, Fujii Shinya, Kawachi Emiko, Ikura Teikichi, Ito Nobutoshi, Yamamoto Keiko, Kagechika Hiroyuki: Development of novel lithocholic acid derivatives as vitamin D receptor agonists BIOORGANIC & MEDICINAL CHEMISTRY. 2019.08; 27 (16): 3674-3681. ( PubMed , DOI )

Den K, Kato M, Yamaguchi T, Miyatake S, Takata A, Mizuguchi T, Miyake N, Mitsuhashi S, Matsumoto N: A novel de novo frameshift variant in SETD1B causes epilepsy. Journal of human genetics. 2019.08; 64 (8): 821-827. ( PubMed , DOI )

Motegi T, Kochi Y, Matsuda K, Kubo M, Yamamoto K, Momozawa Y: Identification of rare coding variants in TYK2 protective for rheumatoid arthritis in the Japanese population and their effects on cytokine signalling. Annals of the rheumatic diseases. 2019.08; 78 (8): 1062-1069. ( PubMed , DOI )

Takemasu Shinya, Nigorikawa Kiyomi, Yamada Miho, Tsurumi Go, Kofuji Satoshi, Takasuga Shunsuke, Hazeki Kaoru: Erk/MAPKによるTMEM55Bのリン酸化はリソソームのポジショニングを制御する(Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning) The Journal of Biochemistry. 2019.08; 166 (2): 175-185. ( ichushi )

Sone J, Mitsuhashi S, Fujita A, Mizuguchi T, Hamanaka K, Mori K, Koike H, Hashiguchi A, Takashima H, Sugiyama H, Kohno Y, Takiyama Y, Maeda K, Doi H, Koyano S, Takeuchi H, Kawamoto M, Kohara N, Ando T, Ieda T, Kita Y, Kokubun N, Tsuboi Y, Katoh K, Kino Y, Katsuno M, Iwasaki Y, Yoshida M, Tanaka F, Suzuki IK, Frith MC, Matsumoto N, Sobue G: Long-read sequencing identifies GGC repeat expansions in NOTCH2NLC associated with neuronal intranuclear inclusion disease. Nature genetics. 2019.08; 51 (8): 1215-1221. ( PubMed , DOI )

Numoto Nobutaka, Fukumori Yoshihiro, Miki Kunio, Ito Nobutoshi: 巨大ヘモグロビンのアロステリック中間体の時分割構造解析(Time-resolved structure analysis of allosteric intermediate of the giant hemoglobin) 生物物理. 2019.08; 59 (Suppl.1-2): S245. ( ichushi )

Yasukochi Shotaro, Numoto Nobutaka, Hori Kiminori, Tenno Natsuko, Tenno Takeshi, Ito Nobutoshi, Hiroaki Hidekazu: ヒトDishevelled1 PDZドメインと阻害剤の共結晶構造解析(Crystal structure of human Dishevelled1 PDZ with its inhibitor) 生物物理. 2019.08; 59 (Suppl.1-2): S240. ( ichushi )

Wolfe K, Kofuji S, Yoshino H, Sasaki M, Okumura K, Sasaki AT: Dynamic compartmentalization of purine nucleotide metabolic enzymes at leading edge in highly motile renal cell carcinoma. Biochemical and biophysical research communications. 2019.08; 516 (1): 50-56. ( PubMed , DOI )

Takemasu S, Nigorikawa K, Yamada M, Tsurumi G, Kofuji S, Takasuga S, Hazeki K: Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning. Journal of biochemistry. 2019.08; 166 (2): 175-185. ( PubMed , DOI )

Kofuji S, Hirayama A, Eberhardt AO, Kawaguchi R, Sugiura Y, Sampetrean O, Ikeda Y, Warren M, Sakamoto N, Kitahara S, Yoshino H, Yamashita D, Sumita K, Wolfe K, Lange L, Ikeda S, Shimada H, Minami N, Malhotra A, Morioka S, Ban Y, Asano M, Flanary VL, Ramkissoon A, Chow LML, Kiyokawa J, Mashimo T, Lucey G, Mareninov S, Ozawa T, Onishi N, Okumura K, Terakawa J, Daikoku T, Wise-Draper T, Majd N, Kofuji K, Sasaki M, Mori M, Kanemura Y, Smith EP, Anastasiou D, Wakimoto H, Holland EC, Yong WH, Horbinski C, Nakano I, DeBerardinis RJ, Bachoo RM, Mischel PS, Yasui W, Suematsu M, Saya H, Soga T, Grummt I, Bierhoff H, Sasaki AT: IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma. Nature cell biology. 2019.08; 21 (8): 1003-1014. ( PubMed , DOI )

Quantifying immune-based counterselection of somatic mutations 2019.07; 15 (7): e1008227. ( PubMed , DOI )

Fujii Yasuyuki, Suzuki Kenta, Adachi Takahiro, Taira Shu, Osakabe Naomi: Corticotropin-releasing hormone is significantly upregulated in the mouse paraventricular nucleus following a single oral dose of cinnamtannin A2 as an (-)-epicatechin tetramer JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION. 2019.07; 65 (1): 29-33. ( DOI )

Lei M, Mitsuhashi S, Miyake N, Ohta T, Liang D, Wu L, Matsumoto N: Translocation breakpoint disrupting the host SNHG14 gene but not coding genes or snoRNAs in typical Prader-Willi syndrome. Journal of human genetics. 2019.07; 64 (7): 647-652. ( PubMed , DOI )

Hamanaka K, Miyatake S, Koshimizu E, Tsurusaki Y, Mitsuhashi S, Iwama K, Alkanaq AN, Fujita A, Imagawa E, Uchiyama Y, Tawara N, Ando Y, Misumi Y, Okubo M, Nakashima M, Mizuguchi T, Takata A, Miyake N, Saitsu H, Iida A, Nishino I, Matsumoto N: RNA sequencing solved the most common but unrecognized NEB pathogenic variant in Japanese nemaline myopathy. Genetics in medicine : official journal of the American College of Medical Genetics. 2019.07; 21 (7): 1629-1638. ( PubMed , DOI )

Fujita A, Higashijima T, Shirozu H, Masuda H, Sonoda M, Tohyama J, Kato M, Nakashima M, Tsurusaki Y, Mitsuhashi S, Mizuguchi T, Takata A, Miyatake S, Miyake N, Fukuda M, Kameyama S, Saitsu H, Matsumoto N: Pathogenic variants of DYNC2H1, KIAA0556, and PTPN11 associated with hypothalamic hamartoma. Neurology. 2019.07; 93 (3): e237-e251. ( PubMed , DOI )

Hamanaka K, Takata A, Uchiyama Y, Miyatake S, Miyake N, Mitsuhashi S, Iwama K, Fujita A, Imagawa E, Alkanaq AN, Koshimizu E, Azuma Y, Nakashima M, Mizuguchi T, Saitsu H, Wada Y, Minami S, Katoh-Fukui Y, Masunaga Y, Fukami M, Hasegawa T, Ogata T, Matsumoto N: MYRF haploinsufficiency causes 46,XY and 46,XX disorders of sex development: bioinformatics consideration. Human molecular genetics. 2019.07; 28 (14): 2319-2329. ( PubMed , DOI )

Naoto Yoshinaga, Eol Cho, Kyoko Koji, Yuki Mochida, Mitsuru Naito, Kensuke Osada, Kazunori Kataoka, Horacio Cabral, Satoshi Uchida: Bundling mRNA Strands to Prepare Nano-Assemblies with Enhanced Stability Towards RNase for In Vivo Delivery Angewandte Chemie International Edition. 2019.06; 58 (33): 11360-11363. ( DOI )

Opposing effects of acute versus chronic inhibition of p53 on decitabine's efficacy in myeloid neoplasms. 2019.06; 9 (1): 8171. ( PubMed , DOI )

Takata A, Nakashima M, Saitsu H, Mizuguchi T, Mitsuhashi S, Takahashi Y, Okamoto N, Osaka H, Nakamura K, Tohyama J, Haginoya K, Takeshita S, Kuki I, Okanishi T, Goto T, Sasaki M, Sakai Y, Miyake N, Miyatake S, Tsuchida N, Iwama K, Minase G, Sekiguchi F, Fujita A, Imagawa E, Koshimizu E, Uchiyama Y, Hamanaka K, Ohba C, Itai T, Aoi H, Saida K, Sakaguchi T, Den K, Takahashi R, Ikeda H, Yamaguchi T, Tsukamoto K, Yoshitomi S, Oboshi T, Imai K, Kimizu T, Kobayashi Y, Kubota M, Kashii H, Baba S, Iai M, Kira R, Hara M, Ohta M, Miyata Y, Miyata R, Takanashi JI, Matsui J, Yokochi K, Shimono M, Amamoto M, Takayama R, Hirabayashi S, Aiba K, Matsumoto H, Nabatame S, Shiihara T, Kato M, Matsumoto N: Comprehensive analysis of coding variants highlights genetic complexity in developmental and epileptic encephalopathy. Nature communications. 2019.06; 10 (1): 2506. ( PubMed , DOI )

Sasaki Junko, Eguchi Satoshi, Nakanishi Hiroki, Sasaki Takehiko: Regulation of cell functions by phosphoinositides　Molecular mechanisms of phosphoinositide signaling(和訳中) The Journal of Physiological Sciences. 2019.06; 69 (Suppl.1): S36. ( ichushi )

Kawai Takafumi, Miyata Haruhiko, Nakanishi Hiroki, Sakata Souhei, Okochi Yoshifumi, Watanabe Masahiko, Sakimura Kenji, Sasaki Takehiko, Ikawa Masahito, Okamura Yasushi: Regulation of cell functions by phosphoinositides　Functional analysis of voltage-sensing phosphatase in mouse sperm(和訳中) The Journal of Physiological Sciences. 2019.06; 69 (Suppl.1): S36. ( ichushi )

Nigorikawa Kiyomi, Matsumura Takuma, Sakamoto Hiromi, Morioka Shin, Kofuji Satoshi, Takasuga Shunsuke, Hazeki Kaoru: Sac1ホスホイノシチドホスファターゼは、マクロファージにおけるSR-A発現を調節することにより、泡沫細胞の形成を制御する(Sac1 Phosphoinositide Phosphatase Regulates Foam Cell Formation by Modulating SR-A Expression in Macrophages) Biological & Pharmaceutical Bulletin. 2019.06; 42 (6): 923-928. ( ichushi )

Tsuchida N, Kirino Y, Soejima Y, Onodera M, Arai K, Tamura E, Ishikawa T, Kawai T, Uchiyama T, Nomura S, Kobayashi D, Taguri M, Mitsuhashi S, Mizuguchi T, Takata A, Miyake N, Nakajima H, Miyatake S, Matsumoto N: Haploinsufficiency of A20 caused by a novel nonsense variant or entire deletion of TNFAIP3 is clinically distinct from Behçet's disease. Arthritis research & therapy. 2019.06; 21 (1): 137. ( PubMed , DOI )

Iwama K, Mizuguchi T, Takeshita E, Nakagawa E, Okazaki T, Nomura Y, Iijima Y, Kajiura I, Sugai K, Saito T, Sasaki M, Yuge K, Saikusa T, Okamoto N, Takahashi S, Amamoto M, Tomita I, Kumada S, Anzai Y, Hoshino K, Fattal-Valevski A, Shiroma N, Ohfu M, Moroto M, Tanda K, Nakagawa T, Sakakibara T, Nabatame S, Matsuo M, Yamamoto A, Yukishita S, Inoue K, Waga C, Nakamura Y, Watanabe S, Ohba C, Sengoku T, Fujita A, Mitsuhashi S, Miyatake S, Takata A, Miyake N, Ogata K, Ito S, Saitsu H, Matsuishi T, Goto YI, Matsumoto N: Genetic landscape of Rett syndrome-like phenotypes revealed by whole exome sequencing. Journal of medical genetics. 2019.06; 56 (6): 396-407. ( PubMed , DOI )

Rahmn SK, Okazawa H, Chen YW: Frameshift PQBP-1 mutants K192Sfs*7 and R153Sfs*41 implicated in X-linked intellectual disability form stable dimers. Journal of Structural Biology. 2019.06; 206 (3): 305-313. ( PubMed , DOI )

Koyano F, Yamano K, Kosako H, Tanaka K, Matsuda N: Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL. The Journal of biological chemistry. 2019.06; 294 (26): 10300-10314. ( PubMed , DOI )

Kanazawa Nobuo, Honda-Ozaki Fumiko, Saito Megumu K.: 中條-西村症候群を再現した人工多能性幹細胞(Induced pluripotent stem cells representing Nakajo-Nishimura syndrome) Inflammation and Regeneration. 2019.05; 39 1 of 8-8 of 8. ( ichushi )

Kazumi Suzuki, Yutaka Miura, Yuki Mochida, Takuya Miyazaki, Kazuko Toh, Yasutaka Anraku, Vinicio Melo, Xueying Liu, Takehiko Ishii, Osamu Nagano, Hideyuki Saya, Horacio Cabral, Kazunori Kataoka: Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors. Journal of Controlled Release. 2019.05; 301 28-41. ( PubMed , DOI )

Aoi H, Lei M, Mizuguchi T, Nishioka N, Goto T, Miyama S, Suzuki T, Iwama K, Uchiyama Y, Mitsuhashi S, Itakura A, Takeda S, Matsumoto N: Nonsense variants in STAG2 result in distinct sex-dependent phenotypes. Journal of human genetics. 2019.05; 64 (5): 487-492. ( PubMed , DOI )

Kiyofumi Takaba, Yang Tai, Haruhiko Eki, Hoang-Anh Dao, Yuya Hanazono, Kazuya Hasegawa, Kunio Miki, Kazuki Takeda: Subatomic resolution X-ray structures of green fluorescent protein. IUCrJ. 2019.05; 6 (3): 387-400. ( PubMed , DOI )

Anjaneyulu Dirisala, Satoshi Uchida, Theofilus A Tockary, Naoto Yoshinaga, Junjie Li, Shigehito Osawa, Lahari Gorantla, Shigeto Fukushima, Kensuke Osada, Kazunori Kataoka: Precise tuning of disulphide crosslinking in mRNA polyplex micelles for optimising extracellular and intracellular nuclease tolerability Journal of Drug Targeting . 2019.04; 27 (5-6): 670-680. ( DOI )

Sumiyo Watanabe, Kotaro Hayashi, Kazuko Toh, Hyun Jin Kim, Xueying Liu, Hiroyuki Chaya, Shigeto Fukushima, Keisuke Katsushima, Yutaka Kondo, Satoshi Uchida, Satomi Ogura, Takahiro Nomoto, Hiroyasu Takemoto, Horacio Cabral, Hiroaki Kinoh, Hiroyoshi Y. Tanaka, Mitsunobu R. Kano, Yu Matsumoto, Hiroshi Fukuhara, Shunya Uchida, Masaomi Nangaku, Kensuke Osada, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka: In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers Nature communications. 2019.04; 10 (1): 1894. ( DOI )

Shota Kurimoto, Naoto Yoshinaga, Kazunori Igarashi, Yu Matsumoto, Horacio Cabral, Satoshi Uchida: PEG-OligoRNA Hybridization of mRNA for Developing Sterically Stable Lipid Nanoparticles toward In Vivo Administration Molecules. 2019.04; 24 (7): 1303. ( DOI )

Mizuguchi T, Nakashima M, Moey LH, Ch'ng GS, Khoo TB, Mitsuhashi S, Miyatake S, Takata A, Miyake N, Saitsu H, Matsumoto N: A novel homozygous truncating variant of NECAP1 in early infantile epileptic encephalopathy: the second case report of EIEE21. Journal of human genetics. 2019.04; 64 (4): 347-350. ( PubMed , DOI )

Yoshikawa Soichiro, Oh-hora Masatsugu, Hashimoto Ryota, Nagao Toshihisa, Peters Louis, Egawa Mayumi, Ohta Takuya, Miyake Kensuke, Adachi Takahiro, Kawano Yohei, Yamanishi Yoshinori, Karasuyama Hajime: Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated murine basophils SCIENCE SIGNALING. 2019.04; 12 (576): ( DOI )

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Chen Y, Xi J, Zhu W, Lin J, Luo S, Yue D, Cai S, Sun C, Zhao C, Mitsuhashi S, Nishino I, Xu M, Lu J: GNE myopathy in Chinese population: hotspot and novel mutations. Journal of human genetics. 2019.01; 64 (1): 11-16. ( PubMed , DOI )

Miki Nishio, Yousuke Miyachi, Junji Otani, Shoji Tane, Hirofumi Omori, Fumihito Ueda, Hideru Togashi, Takehiko Sasaki, Tak Wah Mak, Kazuwa Nakao, Yasuyuki Fujita, Hiroshi Nishina, Tomohiko Maehama, Akira Suzuki: Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency. FASEB J.. 2019.01; 33 (4): fj201802005R. ( PubMed , DOI )

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Yurina Miyashita, Nobutaka Numoto, Sundaram Arulmozhiraja, Shogo Nakano, Naoya Matsuo, Kanade Shimizu, Osamu Shibahara, Michiko Fujihara, Hiroki Kakuta, Sohei Ito, Teikichi Ikura, Nobutoshi Ito, Hiroaki Tokiwa: Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor α (RXRα). FEBS Lett.. 2019.01; 593 (2): 242-250. ( PubMed , DOI )

Isobe Y, Nigorikawa K, Tsurumi G, Takemasu S, Takasuga S, Kofuji S, Hazeki K: PIKfyve accelerates phagosome acidification through activation of TRPML1 while arrests aberrant vacuolation independent of the Ca2+ channel. Journal of biochemistry. 2019.01; 165 (1): 75-84. ( PubMed , DOI )

Yamaguchi A, Ishikawa H, Furuoka M, Yokozeki M, Matsuda N, Tanimura S, Takeda K: Cleaved PGAM5 is released from mitochondria depending on proteasome-mediated rupture of the outer mitochondrial membrane during mitophagy. Journal of biochemistry. 2019.01; 165 (1): 19-25. ( PubMed , DOI )

Yamaguchi Ayane, Ishikawa Hayate, Furuoka Mana, Yokozeki Masashi, Matsuda Noriyuki, Tanimura Susumu, Takeda Kohsuke: 切断型PGAM5はマイトファジー中のミトコンドリア外膜のプロテオソーム介在性断裂に応じてミトコンドリアから放出される(Cleaved PGAM5 is released from mitochondria depending on proteasome-mediated rupture of the outer mitochondrial membrane during mitophagy) The Journal of Biochemistry. 2019.01; 165 (1): 19-25. ( ichushi )

Hosoe Y, Numoto N, Inaba S, Ogawa S, Morii H, Abe R, Ito N, Oda M: Structural and functional properties of Grb2 SH2 dimer in CD28 binding. Biophysics and physicobiology. 2019; 16 80-88. ( PubMed , DOI )

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Fujioka Yoichiro, Satoh Aya O., Horiuchi Kosui, Fujioka Mari, Tsutsumi Kaori, Sasaki Junko, Nepal Prabha, Kashiwagi Sayaka, Paudel Sarad, Nishide Shinya, Nanbo Asuka, Sasaki Takehiko, Ohba Yusuke: A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection CELL STRUCTURE AND FUNCTION. 2019; 44 (1): 61-74.

Yu-Hsin Wang, Chun-Bing Chen, Wichittra Tassaneeyakul, Yoshiro Saito, Michiko Aihara, Siew Eng Choon, Haur Yueh Lee, Mimi Mee Chang, Francisca D Roa, Cheng-Wei Wu, Jing Zhang, Nontaya Nakkam, Parinya Konyoung, Yoshimi Okamoto-Uchida, Christina Man-Tung Cheung, Jin-Wen Huang, Chao Ji, Bo Cheng, Rosaline Chung-Yee Hui, Chia-Yu Chu, Yi-Ju Chen, Ching-Ying Wu, Chao-Kai Hsu, Tsu-Man Chiu, Yu-Huei Huang, Chun-Wei Lu, Chin-Yi Yang, Yi-Ting Lin, Min-Hui Chi, Hsin-Chun Ho, Jing-Yi Lin, Chih-Hsun Yang, Ya-Ching Chang, Shih-Chi Su, Chuang Wei Wang, Wen-Lang Fan, Shuen-Iu Hung, Wen-Hung Chung, : The Medication Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Asians: The Major Drug Causality and Comparison With the US FDA Label. Clin Pharmacol Ther. 2019; 105 (1): 112-120.

Ikura T, Yonezawa Y, Ito N: Mutational effects of Cys113 on structural dynamics of Pin1. Biophysics and physicobiology. 2019; 16 452-465. ( PubMed , DOI )

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Yoshino H, Yin G, Kawaguchi R, Popov KI, Temple B, Sasaki M, Kofuji S, Wolfe K, Kofuji K, Okumura K, Randhawa J, Malhotra A, Majd N, Ikeda Y, Shimada H, Kahoud ER, Haviv S, Iwase S, Asara JM, Campbell SL, Sasaki AT: Correction: Identification of lysine methylation in the core GTPase domain by GoMADScan. PloS one. 2019; 14 (10): e0224443. ( PubMed , DOI )

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Sasaki-Honda M, Jonouchi T, Arai M, Hotta A, Mitsuhashi S, Nishino I, Matsuda R, Sakurai H: A patient-derived iPSC model revealed oxidative stress increases facioscapulohumeral muscular dystrophy-causative DUX4. Human molecular genetics. 2018.12; 27 (23): 4024-4035. ( PubMed , DOI )

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Kumazawa T, Nishimura A, Asai N, Adachi T: Isolation of immune-regulatory Tetragenococcus halophilus from miso. PLOS ONE. 2018.12; 13 (12): e0208821 . ( DOI )

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Tabu Kouichi, Taga Tetsuya: A monocyte-recruiting phenotype defines functional heterogeneity of glioma cells with stemness and chemoresistance CANCER SCIENCE. 2018.12; 109 1308.

Chikashi Terao, Hajime Yoshifuji, Takayoshi Matsumura, Taeko K Naruse, Tomonori Ishii, Yoshikazu Nakaoka, Yohei Kirino, Keitaro Matsuo, Tomoki Origuchi, Masakazu Shimizu, Yasuhiro Maejima, Eisuke Amiya, Natsuko Tamura, Takahisa Kawaguchi, Meiko Takahashi, Kazuya Setoh, Koichiro Ohmura, Ryu Watanabe, Tetsuya Horita, Tatsuya Atsumi, Mitsuru Matsukura, Tetsuro Miyata, Yuta Kochi, Toshio Suda, Kazuo Tanemoto, Akira Meguro, Yukinori Okada, Akiyoshi Ogimoto, Motohisa Yamamoto, Hiroki Takahashi, Shingo Nakayamada, Kazuyoshi Saito, Masataka Kuwana, Nobuhisa Mizuki, Yasuharu Tabara, Atsuhisa Ueda, Issei Komuro, Akinori Kimura, Mitsuaki Isobe, Tsuneyo Mimori, Fumihiko Matsuda: Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritis Proc. Natl. Acad. Sci. U.S.A.. 2018.11; 115 (51): 13045-13050. ( PubMed , DOI )

Sato K, Otomo A, Ueda MT, Hiratsuka Y, Suzuki-Utsunomiya K, Sugiyama J, Murakoshi S, Mitsui S, Ono S, Nakagawa S, Shang HF, Hadano S: Altered oligomeric states in pathogenic ALS2 variants associated with juvenile motor neuron diseases cause loss of ALS2-mediated endosomal function. The Journal of biological chemistry. 2018.11; 293 (44): 17135-17153. ( PubMed , DOI )

Imagawa E, Albuquerque EVA, Isidor B, Mitsuhashi S, Mizuguchi T, Miyatake S, Takata A, Miyake N, Boguszewski MCS, Boguszewski CL, Lerario AM, Funari MA, Jorge AAL, Matsumoto N: Novel SUZ12 mutations in Weaver-like syndrome. Clinical genetics. 2018.11; 94 (5): 461-466. ( PubMed , DOI )

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Espiritu EB, Crunk AE, Bais A, Hochbaum D, Cervino AS, Phua YL, Butterworth MB, Goto T, Ho J, Hukriede NA, Cirio MC: The Lhx1-Ldb1 complex interacts with Furry to regulate microRNA expression during pronephric kidney development. Scientific reports. 2018.10; 8 (1): 16029. ( PubMed , DOI )

Iwama K, Osaka H, Ikeda T, Mitsuhashi S, Miyatake S, Takata A, Miyake N, Ito S, Mizuguchi T, Matsumoto N: A novel SLC9A1 mutation causes cerebellar ataxia. Journal of human genetics. 2018.10; 63 (10): 1049-1054. ( PubMed , DOI )

Shunsuke Kawamura, Toshiaki Ohteki: Monopoiesis in humans and mice. Int. Immunol.. 2018.10; 30 (11): 503-509. ( PubMed , DOI )

Tsuchida Y, Sumitomo S, Ota M, Tsuchiya H, Nagafuchi Y, Shoda H, Fujio K, Ishigaki K, Yamaguchi K, Suzuki A, Kochi Y, Yamamoto K: Reduction of CD83 Expression on B Cells and the Genetic Basis for Rheumatoid Arthritis: Comment on the Article by Thalayasingam et al. Arthritis & rheumatology (Hoboken, N.J.). 2018.10; 70 (10): 1695-1696. ( PubMed , DOI )

Hitoshi Okazawa: PQBP1, an intrinsically disordered/denatured protein at the crossroad of intellectual disability and neurodegenerative diseases. Neurochem Int. 2018.10; 119 17-25. ( PubMed , DOI )

Jin K, Imada T, Nakamura S, Izuta Y, Oonishi E, Shibuya M, Sakaguchi H, Adachi T, Tsubota K: Intravital Two-photon Imaging of Ca 2+ signaling in Secretory Organs of Yellow Cameleon Transgenic Mice. Scientific reports. 2018.10; 8 (1): 15880. ( PubMed , DOI )

Yamano K, Lazarou M: YoungMito 2018: Report on the 1st International Mitochondria Meeting for Young Scientists. Genes to cells : devoted to molecular & cellular mechanisms. 2018.10; 23 (10): 822-827. ( PubMed , DOI )

Tanaka H, Kondo K, Chen X, Homma H, Tagawa K, Kerever A, Aoki S, Saito T, Saido T, Muramatsu S, Fujita K, Okazawa H: The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology. Mol psychiatry. 2018.10; 23 (10): 2090-2110. ( PubMed , DOI )

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椨 康一, 田賀 哲也: グリオーマにおける単球動員亜集団は幹細胞性と薬剤耐性を有する(A monocyte-recruiting phenotype defines functional heterogeneity of glioma cells with stemness and chemoresistance) 日本癌学会総会記事. 2018.09; 77回 2314. ( ichushi )

Rocio Otero, Michiyasu Ishizawa, Nobutaka Numoto, Teikichi Ikura, Nobutoshi Ito, Hiroaki Tokiwa, Antonio Mouriño, Makoto Makishima, Sachiko Yamada: Synthesis, Tissue Selective Biological Activities, and X-ray Crystal Structural Analysis of Its Vitamin D Receptor Complex. J. Med. Chem.. 2018.08; 61 (15): 6658-6673. ( PubMed , DOI )

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Ikuo Nobuhisa, Takahishi Satomi, Saito Kiyoka, Taga Tetsuya: 癌免疫療法における免疫応答　妊娠中期マウス胚の大動脈内造血細胞クラスター形成における転写因子Sox17によって誘導される接着分子の役割(Hematopoiesis and immune environments　Role of adhesion molecules induced by a transcription factor Sox17 in intra-aortic hematopoietic cell cluster formation in midgestation mouse embryos) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 1-G. ( ichushi )

Mingguo Huang, Shintaro Narita, Takamitsu Inoue, Atsushi Koizumi, Mitsuru Saito, Hiroshi Tsuruta, Kazuyuki Numakura, Shigeru Satoh, Hiroshi Nanjo, Takehiko Sasaki, Tomonori Habuchi: Fatty acid binding protein 4 enhances prostate cancer progression by upregulating matrix metalloproteinases and stromal cell cytokine production. Oncotarget. 2017.12; 8 (67): 111780-111794. ( PubMed , DOI )

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Nobuyuki Onai, Jumpei Asano, Rumiko Kurosaki, Shoko Kuroda, Toshiaki Ohteki: Flexible fate commitment of E2-2high common DC progenitors implies tuning in tissue microenvironments. Int. Immunol.. 2017.12; 29 (10): 443-456. ( PubMed , DOI )

Takahiro Adachi, Yoshikawa Soichiro, Karasuyama Hajime: B cell development and function Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 3-E.

Naoto Yoshinaga, Takehiko Ishii, Mitsuru Naito, Taisuke Endo, Satoshi Uchida, Horacio Cabral, Kensuke Osada, Kazunori Kataoka: Polyplex micelles with phenylboronate/gluconamide cross-linking in the core exerting promoted gene transfection through spatiotemporal responsivity to intracellular pH and ATP concentration Journal of the American Chemical Society. 2017.11; 139 (51): 18567-18575. ( DOI )

Tatsuyuki Matsudaira, Kojiro Mukai, Taishin Noguchi, Junya Hasegawa, Tomohisa Hatta, Shun-Ichiro Iemura, Tohru Natsume, Norio Miyamura, Hiroshi Nishina, Jun Nakayama, Kentaro Semba, Takuya Tomita, Shigeo Murata, Hiroyuki Arai, Tomohiko Taguchi: Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells. Nat Commun. 2017.11; 8 (1): 1246. ( PubMed , DOI )

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Ishiyama A, Sakai C, Matsushima Y, Noguchi S, Mitsuhashi S, Endo Y, Hayashi YK, Saito Y, Nakagawa E, Komaki H, Sugai K, Sasaki M, Sato N, Nonaka I, Goto YI, Nishino I: IBA57 mutations abrogate iron-sulfur cluster assembly leading to cavitating leukoencephalopathy. Neurology. Genetics. 2017.10; 3 (5): e184. ( PubMed , DOI )

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Aiko Watanabe, David C Poole, Yutaka Kano: The effects of RSR13 on microvascular Po2 kinetics and muscle contractile performance in the rat arterial ligation model of peripheral arterial disease J Appl Physiol (1985). 2017.10; 123 (4): 764-772. ( PubMed , DOI )

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Fujita K., Motoki K., Tagawa K., Chen X., Hama H., Nakajima K., Homma H., Tamura T., Miyawaki A., Okazawa H.: HMGB1 triggers neurite degeneration via TLR4-MARCKS, and is a potential therapeutic target for alzheimer's disease JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 64-65. ( DOI )

Matsuda N, Kimura M, Queliconi BB, Kojima W, Mishima M, Takagi K, Koyano F, Yamano K, Mizushima T, Ito Y, Tanaka K: Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro. Scientific reports. 2017.10; 7 (1): 12816. ( PubMed , DOI )

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Okamoto-Uchida Yoshimi, Nakamura Ryosuke, Sai Kimie, Imatoh Takuya, Matsunaga Kayoko, Aihara Michiko, Saito Yoshiro: Stevens-Johnson症候群および中毒性表皮壊死症の病因に及ぼす感染症の影響(Effect of Infectious Diseases on the Pathogenesis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis) Biological & Pharmaceutical Bulletin. 2017.09; 40 (9): 1576-1580. ( ichushi )

Tagawa Hiroyuki, Abe Fumito, Nakanishi Hiroki, Kitadate Akihiro, Ikeda Sho, Takahashi Naoto, Sasaki Takehiko: 脂質定量解析による悪性リンパ腫の新たな診断マーカーの同定(Phosphatidylinositol phosphates profile reveals novel diagnostic marker(s) in malignant lymphoma) 臨床血液. 2017.09; 58 (9): 1742. ( ichushi )

阿部 史人, 中西 広樹, 北舘 明宏, 池田 翔, 亀岡 吉弘, 高橋 直人, 佐々木 雄彦, 田川 博之: 悪性リンパ腫におけるイノシトールリン脂質プロファイル 日本癌学会総会記事. 2017.09; 76回 P-2236. ( ichushi )

Ryo Ichijo, Hiroki Kobayashi, Saori Yoneda, Yui Iizuka, Hirokazu Kubo, Shigeru Matsumura, Satsuki Kitano, Hitoshi Miyachi, Tetsuya Honda, Fumiko Toyoshima: Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration NATURE COMMUNICATIONS. 2017.09; 8 (1): 508. ( PubMed , DOI )

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Kazuki Miyano, Horacio Cabral, Yutaka Miura, Yu Matsumoto, Yuki Mochida, Hiroaki Kinoh, Caname Iwata, Osamu Nagano, Hideyuki Saya, Nobuhiro Nishiyama, Kazunori Kataoka, Tatsuya Yamasoba: cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells. Journal of Controlled Release. 2017.09; 261 275-286. ( DOI )

Satoshi Uchida, Naoto Yoshinaga, Kayoko Yanagihara, Eiji Yuba, Kazunori Kataoka, Keiji Itaka: Designing immunostimulatory double stranded messenger RNA with maintained translational activity through hybridization with poly A sequences for effective vaccination. Biomaterials. 2017.09; ( PubMed , DOI )

室田 吉貴, 椨 康一, 田賀 哲也: p53ノックアウトマウスアストロサイトへのH-RasV12導入によるマウスグリオーマモデルの樹立 日本癌学会総会記事. 2017.09; 76回 P-2120. ( ichushi )

Yuta Shinohara, Yohei M. Koyama, Maki Ukai-Tadenuma, Takatsugu Hirokawa, Masaki Kikuchi, Rikuhiro G. Yamada, Hideki Ukai, Hiroshi Fujishima, Takashi Umehara, Kazuki Tainaka, Hiroki R. Ueda: Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock. Molecular cell. 2017.09; 67 (5): 783-798. ( DOI )

椨 康一, 室田 吉貴, 田賀 哲也: グリオーマ幹細胞のマクロファージを利用した鉄欠乏ストレスへの適応・生存戦略 日本癌学会総会記事. 2017.09; 76回 P-3156. ( ichushi )

Okamoto-Uchida Yoshimi, Nakamura Ryosuke, Sai Kimie, Imatoh Takuya, Matsunaga Kayoko, Aihara Michiko, Saito Yoshiro: Stevens-Johnson症候群および中毒性表皮壊死症の病因に及ぼす感染症の影響(Effect of Infectious Diseases on the Pathogenesis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis) Biological & Pharmaceutical Bulletin. 2017.09; 40 (9): 1576-1580.

Dian-Jang Lee, Eva Kessel, Taavi Lehto, Xueying Liu, Naoto Yoshinaga, Kärt Padari, Ying-Chen Chen, Susanne Kempter, Satoshi Uchida, Joachim O. Rädler, Margus Pooga, Ming-Thau Sheu, Kazunori Kataoka, Ernst Wagner: Systemic Delivery of Folate-PEG siRNA Lipopolyplexes with Enhanced Intracellular Stability for In Vivo Gene Silencing in Leukemia Bioconjugate Chemistry. 2017.08; 28 (9): 2393-2409. ( DOI )

Ikura Teikichi, Ito Nobutoshi: タウタンパク質に対するPin1由来のプロテアーゼの活性の定量的評価(Quantitative evaluation of activity of a protease derived from Pin1 for tau protein) 生物物理. 2017.08; 57 (Suppl.1-2): S315. ( ichushi )

Numoto Nobutaka, Akatsu Chizuru, Shinagawa Kenro, Tsubata Takeshi, Ito Nobutoshi: B細胞抑制性因子CD72の分子表面電荷分布によるリガンド結合制御機構(Charge distribution regulates the ligand-binding affinity of B cell inhibitory receptor CD72) 生物物理. 2017.08; 57 (Suppl.1-2): S276. ( ichushi )

Saha M, Mitsuhashi S, Jones MD, Manko K, Reddy HM, Bruels CC, Cho KA, Pacak CA, Draper I, Kang PB: Consequences of MEGF10 deficiency on myoblast function and Notch1 interactions. Human molecular genetics. 2017.08; 26 (15): 2984-3000. ( PubMed , DOI )

Okubo M, Goto K, Komaki H, Nakamura H, Mori-Yoshimura M, Hayashi YK, Mitsuhashi S, Noguchi S, Kimura E, Nishino I: Comprehensive analysis for genetic diagnosis of Dystrophinopathies in Japan. Orphanet journal of rare diseases. 2017.08; 12 (1): 149. ( PubMed , DOI )

Jun Negishi, Yuka Omori, Mami Shindo, Hayate Takanashi, Shiori Musha, Suminori Nagayama, Jun Hirayama, Hiroshi Nishina, Takashi Nakakura, Chihiro Mogi, Koichi Sato, Fumikazu Okajima, Yuta Mochimaru, Hideaki Tomura: Manganese and cobalt activate zebrafish ovarian cancer G-protein-coupled receptor 1 but not GPR4. J. Recept. Signal Transduct. Res.. 2017.08; 37 (4): 401-408. ( PubMed , DOI )

Tokiwa Yamasaki, Norie Deki-Arima, Asahito Kaneko, Norio Miyamura, Mamiko Iwatsuki, Masato Matsuoka, Noriko Fujimori-Tonou, Yoshimi Okamoto-Uchida, Jun Hirayama, Jamey D Marth, Yuji Yamanashi, Hiroshi Kawasaki, Koji Yamanaka, Josef M Penninger, Shigenobu Shibata, Hiroshi Nishina: Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. Sci Rep. 2017.08; 7 (1): 7348. ( PubMed , DOI )

Jumpei Asano, Taku Sato, Shizuko Ichinose, Mihoko Kajita, Nobuyuki Onai, Shigeomi Shimizu, Toshiaki Ohteki: Intrinsic Autophagy Is Required for the Maintenance of Intestinal Stem Cells and for Irradiation-Induced Intestinal Regeneration. Cell Rep. 2017.08; 20 (5): 1050-1060. ( PubMed , DOI )

Horibata Y, Ando H, Satou M, Shimizu H, Mitsuhashi S, Shimizu Y, Itoh M, Sugimoto H: Identification of the N-terminal transmembrane domain of StarD7 and its importance for mitochondrial outer membrane localization and phosphatidylcholine transfer. Scientific reports. 2017.08; 7 (1): 8793. ( PubMed , DOI )

Matsumoto Hirotaka, Kiryu Hisanori, Furusawa Chikara, Ko Minoru S. H., Ko Shigeru B. H., Gouda Norio, Hayashi Tetsutaro, Nikaido Itoshi: SCODE: an efficient regulatory network inference algorithm from single-cell RNA-Seq during differentiation BIOINFORMATICS. 2017.08; 33 (15): 2314-2321. ( PubMed , DOI )

Yoshida Y, Yasuda S, Fujita T, Hamasaki M, Murakami A, Kawawaki J, Iwai K, Saeki Y, Yoshimori T, Matsuda N, Tanaka K: Ubiquitination of exposed glycoproteins by SCF(FBXO27) directs damaged lysosomes for autophagy. Proceedings of the National Academy of Sciences of the United States of America. 2017.08; 114 (32): 8574-8579. ( PubMed , DOI )

Izumikawa K, Nobe Y, Yoshikawa H, Ishikawa H, Miura Y, Nakayama H, Nonaka T, Hasegawa M, Egawa N, Inoue H, Nishikawa K, Yamano K, Simpson RJ, Taoka M, Yamauchi Y, Isobe T, Takahashi N: TDP-43 stabilises the processing intermediates of mitochondrial transcripts. Scientific reports. 2017.08; 7 (1): 7709. ( PubMed , DOI )

Ishigaki Kazuyoshi, Kochi Yuta, Suzuki Akari, Tsuchida Yumi, Tsuchiya Haruka, Sumitomo Shuji, Yamaguchi Kensuke, Nagafuchi Yasuo, Nakachi Shinichiro, Kato Rika, Sakurai Keiichi, Shoda Hirofumi, Ikari Katsunori, Taniguchi Atsuo, Yamanaka Hisashi, Miya Fuyuki, Tsunoda Tatsuhiko, Okada Yukinori, Momozawa Yukihide, Kamatani Yoichiro, Yamada Ryo, Kubo Michiaki, Fujio Keishi, Yamamoto Kazuhiko: Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis NATURE GENETICS. 2017.07; 49 (7): 1120-+. ( PubMed , DOI )

Mitsuhashi S, Kryukov K, Nakagawa S, Takeuchi JS, Shiraishi Y, Asano K, Imanishi T: A portable system for rapid bacterial composition analysis using a nanopore-based sequencer and laptop computer. Scientific reports. 2017.07; 7 (1): 5657. ( PubMed , DOI )

K Otsubo, H Goto, M Nishio, K Kawamura, S Yanagi, W Nishie, T Sasaki, T Maehama, H Nishina, K Mimori, T Nakano, H Shimizu, T W Mak, K Nakao, Y Nakanishi, A Suzuki: MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation. Oncogene. 2017.07; 36 (29): 4201-4211. ( PubMed , DOI )

Masashi Kanayama, Shengjie Xu, Keiko Danzaki, Jason R Gibson, Makoto Inoue, Simon G Gregory, Mari L Shinohara: Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin. Nature Immunology. 2017.07; ( PubMed , DOI )

Yoshiko Iizuka-Hishikawa, Daisuke Hishikawa, Junko Sasaki, Keiyo Takubo, Motohito Goto, Katsuyuki Nagata, Hiroki Nakanishi, Hideo Shindou, Tadashi Okamura, Chizuru Ito, Kiyotaka Toshimori, Takehiko Sasaki, Takao Shimizu: Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis. J. Biol. Chem.. 2017.07; 292 (29): 12065-12076. ( PubMed , DOI )

Hideo Shindou, Hideto Koso, Junko Sasaki, Hiroki Nakanishi, Hiroshi Sagara, Koh M Nakagawa, Yoshikazu Takahashi, Daisuke Hishikawa, Yoshiko Iizuka-Hishikawa, Fuyuki Tokumasu, Hiroshi Noguchi, Sumiko Watanabe, Takehiko Sasaki, Takao Shimizu: Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells. J. Biol. Chem.. 2017.07; 292 (29): 12054-12064. ( PubMed , DOI )

Harada K, Nobuhisa I, Anani M, Saito K, Taga T: Thrombopoietin contributes to the formation and the maintenance of hematopoietic progenitor-containing cell clusters in the aorta-gonad-mesonephros region. Cytokine. 2017.07; 95 32-42. ( DOI )

Norio Miyamura, Shoji Hata, Tohru Itoh, Minoru Tanaka, Miki Nishio, Michiko Itoh, Yoshihiro Ogawa, Shuji Terai, Isao Sakaida, Akira Suzuki, Atsushi Miyajima, Hiroshi Nishina: YAP determines the cell fate of injured mouse hepatocytes in vivo. Nat Commun. 2017.07; 8 16017. ( PubMed , DOI )

Nitta T, Kochi Y, Muro R, Tomofuji Y, Okamura T, Murata S, Suzuki H, Sumida T, Yamamoto K, Takayanagi H: Human thymoproteasome variations influence CD8 T cell selection. Science immunology. 2017.06; 2 (12): ( PubMed , DOI )

Michiue T, Yamamoto T, Yasuoka Y, Goto T, Ikeda T, Nagura K, Nakayama T, Taira M, Kinoshita T.: High variability of expression profiles of homeologous genes for Wnt, Hh, Notch, and Hippo signaling pathways in Xenopus laevis. Dev Biol.. 2017.06; 426 (2): 270-290. ( PubMed , DOI )

Hitoshi Okazawa: Ultra-Early Phase pathologies of Alzheimer's disease and other neurodegenerative diseases. Proc Jpn Acad Ser B Phys Biol Sci. 2017.06; 93 (6): 361-377. ( PubMed , DOI )

Toshihiro Imada, Jin Kai, Izuta Yusuke, Nakamura Shigeru, Adachi Takahiro, Tsubota Kazuo: In vivo dynamics of Ca2+-dependent myoepithelial contraction in lacrimal gland INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2017.06; 58 (8):

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Shunsuke Kawamura, Nobuyuki Onai, Fuyuki Miya, Taku Sato, Tatsuhiko Tsunoda, Kazutaka Kurabayashi, Satoshi Yotsumoto, Shoko Kuroda, Katsuto Takenaka, Koichi Akashi, Toshiaki Ohteki: Identification of a Human Clonogenic Progenitor with Strict Monocyte Differentiation Potential: A Counterpart of Mouse cMoPs. Immunity. 2017.05; 46 (5): 835-848.e4. ( PubMed , DOI )

Hiraku Ohno, Kazuki Takeda, Satomi Niwa, Tomotaka Tsujinaka, Yuya Hanazono, Yu Hirano, Kunio Miki: Crystallographic characterization of the high-potential iron-sulfur protein in the oxidized state at 0.8 Å resolution. PLoS One. 2017.05; 12 (5): e0178183. ( PubMed , DOI )

Yuichi Amano, Masaki Kikuchi, Shin Sato, Shigeyuki Yokoyama, Takashi Umehara, Naoki Umezawa, Tsunehiko Higuchi: Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1. Bioorganic & Medicinal Chemistry. 2017.05; 25 (9): 2617-2624. ( DOI )

Nagano-Shoji M, Hamamoto Y, Mizuno Y, Yamada A, Kikuchi M, Shirouzu M, Umehara T, Yoshida M, Nishiyama M, Kosono S: Characterization of lysine acetylation of a phosphoenolpyruvate carboxylase involved in glutamate overproduction in Corynebacterium glutamicum. Molecular Microbiology. 2017.05;

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Taro Watabe, Takashi Nagaishi, Akinori Hosoya, Nisha Jose, Arisa Tokai, Yudai Kojima, Takahiro Adachi, Mamoru Watanabe: THE LACK OF SECRETED IGA SPONTANEOUSLY INDUCES THE MUCOSAL INFLAMMATION SPECIFICALLY IN THE ILEUM GASTROENTEROLOGY. 2017.04; 152 (5): S1004.

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Matsumoto J, Nakanishi H, Kunii Y, Sugiura Y, Yuki D, Wada A, Hino M, Niwa SI, Kondo T, Waki M, Hayasaka T, Masaki N, Akatsu H, Hashizume Y, Yamamoto S, Sato S, Sasaki T, Setou M, Yabe H: Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia. Scientific reports. 2017.03; 7 45050. ( PubMed , DOI )

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Seiichiro Mori, Takamasa Takeuchi, Yoshiyuki Ishii, Takashi Yugawa, Tohru Kiyono, Hiroshi Nishina, Iwao Kukimoto: Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor. J. Virol.. 2017.03; 91 (6): ( PubMed , DOI )

Yuki Mochida, Horacio Cabral, Kazunori Kataoka: Polymeric micelles for targeted tumor therapy of platinum anticancer drugs. Expert Opinion on Drug Delivery. 2017.03; 14 (12): 1423-1438. ( DOI )

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Federico Perche, Satoshi Uchida, Hiroki Akiba, Chin-Yu Lin, Masaru Ikegami, Anjaneyulu Dirisala, Toshihiro Nakashima, Keiji Itaka, Kohei Tsumoto, Kazunori Kataoka: Improved Brain Expression of Anti-Amyloid β scFv by Complexation of mRNA Including a Secretion Sequence with PEG-based Block Catiomer. Curr Alzheimer Res. 2017.03; 14 (3): 295-302. ( PubMed , DOI )

Yamanishi E, Hasegawa K, Fujita K, Ichinose S, Yagishita S, Murata M, Tagawa K, Akashi T, Eishi Y, Okazawa H: A novel form of necrosis, TRIAD, occurs in human Huntington's disease. Acta Neuropathol Commun. 2017.03; 5 (1): 19. ( PubMed , DOI )

Ueda MT, Kurosaki Y, Izumi T, Nakano Y, Oloniniyi OK, Yasuda J, Koyanagi Y, Sato K, Nakagawa S: Functional mutations in spike glycoprotein of Zaire ebolavirus associated with an increase in infection efficiency. Genes to cells : devoted to molecular & cellular mechanisms. 2017.02; 22 (2): 148-159. ( PubMed , DOI )

Reddy HM, Cho KA, Lek M, Estrella E, Valkanas E, Jones MD, Mitsuhashi S, Darras BT, Amato AA, Lidov HG, Brownstein CA, Margulies DM, Yu TW, Salih MA, Kunkel LM, MacArthur DG, Kang PB: The sensitivity of exome sequencing in identifying pathogenic mutations for LGMD in the United States. Journal of human genetics. 2017.02; 62 (2): 243-252. ( PubMed , DOI )

Nishikawa A, Mitsuhashi S, Miyata N, Nishino I: Targeted massively parallel sequencing and histological assessment of skeletal muscles for the molecular diagnosis of inherited muscle disorders. Journal of medical genetics. 2017.02; 54 (2): 104-110. ( PubMed , DOI )

Liang WC, Uruha A, Suzuki S, Murakami N, Takeshita E, Chen WZ, Jong YJ, Endo Y, Komaki H, Fujii T, Kawano Y, Mori-Yoshimura M, Oya Y, Xi J, Zhu W, Zhao C, Watanabe Y, Ikemoto K, Nishikawa A, Hamanaka K, Mitsuhashi S, Suzuki N, Nishino I: Pediatric necrotizing myopathy associated with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibodies. Rheumatology (Oxford, England). 2017.02; 56 (2): 287-293. ( PubMed , DOI )

Zhu W, Mitsuhashi S, Yonekawa T, Noguchi S, Huei JC, Nalini A, Preethish-Kumar V, Yamamoto M, Murakata K, Mori-Yoshimura M, Kamada S, Yahikozawa H, Karasawa M, Kimura S, Yamashita F, Nishino I: Missing genetic variations in GNE myopathy: rearrangement hotspots encompassing 5'UTR and founder allele. Journal of human genetics. 2017.02; 62 (2): 159-166. ( PubMed , DOI )

Wang W, Tabu K, Hagiya Y, Sugiyama Y, Kokubu Y, Murota Y, Ogura SI, and Taga T: Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation. Sci Rep. 2017.02; 7 42070. ( PubMed , DOI )

Sivan Cohen, Keiko Danzaki, Nancie J MacIver: Nutritional effects on T-cell immunometabolism. European Journal of Immunology. 2017.02; 47 (2): 225-235. ( PubMed , DOI )

Miyatake S, Mitsuhashi S, Hayashi YK, Purevjav E, Nishikawa A, Koshimizu E, Suzuki M, Yatabe K, Tanaka Y, Ogata K, Kuru S, Shiina M, Tsurusaki Y, Nakashima M, Mizuguchi T, Miyake N, Saitsu H, Ogata K, Kawai M, Towbin J, Nonaka I, Nishino I, Matsumoto N: Biallelic Mutations in MYPN, Encoding Myopalladin, Are Associated with Childhood-Onset, Slowly Progressive Nemaline Myopathy. American journal of human genetics. 2017.01; 100 (1): 169-178. ( PubMed , DOI )

Yoichi Asaoka, Hiroshi Nishina, Makoto Furutani-Seiki: YAP is essential for 3D organogenesis withstanding gravity. Dev. Growth Differ.. 2017.01; 59 (1): 52-58. ( PubMed , DOI )

Hirotaka Kimura, Satoshi Eguchi, Junko Sasaki, Keiji Kuba, Hiroki Nakanishi, Shunsuke Takasuga, Masakazu Yamazaki, Akiteru Goto, Hiroyuki Watanabe, Hiroshi Itoh, Yumiko Imai, Akira Suzuki, Noboru Mizushima, Takehiko Sasaki: Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy. JCI Insight. 2017.01; 2 (1): e89462. ( PubMed , DOI )

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Satomi Inaba, Nobutaka Numoto, Shuhei Ogawa, Hisayuki Morii, Teikichi Ikura, Ryo Abe, Nobutoshi Ito, Masayuki Oda: Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins. J. Biol. Chem.. 2017.01; 292 (3): 1052-1060. ( PubMed , DOI )

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Asaoka Yoichi, Nishina Hiroshi, Furutani-Seiki Makoto: 【発生時のサイズ】YAPは重力に抵抗性の3D器官形成にとって必須である(【Size in development】YAP is essential for 3D organogenesis withstanding gravity) Development, Growth & Differentiation. 2017.01; 59 (1): 52-58. ( ichushi )

Okamoto-Uchida Y, Nakamura R, Sai K, Imatoh T, Matsunaga K, Aihara M, Saito Y: Effect of Infectious Diseases on the Pathogenesis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Biological & pharmaceutical bulletin. 2017; 40 (9): 1576-1580. ( PubMed , DOI )

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Tsuchida Y, Sumitomo S, Ishigaki K, Suzuki A, Kochi Y, Tsuchiya H, Ota M, Komai T, Inoue M, Morita K, Okamura T, Yamamoto K, Fujio K: TGF-β3 Inhibits Antibody Production by Human B Cells. PloS one. 2017; 12 (1): e0169646. ( PubMed , DOI )

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Takayuki Yokoi, Kentarou Yokoi, Kazumasa Akiyama, Takashi Higuchi, Yohta Shimada, Hiroshi Kobayashi, Taku Sato, Toshiaki Ohteki, Makoto Otsu, Hiromitsu Nakauchi, Hiroyuki Ida, Toya Ohashi: Non-myeloablative preconditioning with ACK2 (anti-c-kit antibody) is efficient in bone marrow transplantation for murine models of mucopolysaccharidosis type II. Mol. Genet. Metab.. 2016.11; 119 (3): 232-238. ( PubMed , DOI )

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Keiko Danzaki, Masashi Kanayama, Oscar Alcazar, Mari L Shinohara: Osteopontin has a protective role in prostate tumor development in mice. European journal of immunology. 2016.11; 46 (11): 2669-2678. ( PubMed , DOI )

Mao Y, Chen X, Xu M, Fujita K, Motoki K, Sasabe T, Homma H, Murata M, Tagawa K, Tamura T, Kaye J, Finkbeiner S, Blandino G, Sudol M, Okazawa H: Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology. Human molecular genetics. 2016.11; 25 (21): 4749-4770. ( PubMed , DOI )

Chizuru Akatsu, Kenro Shinagawa, Nobutaka Numoto, Zhihong Liu, Ayse Konuskan Ucar, Mohammad Aslam, Shirly Phoon, Takahiro Adachi, Koji Furukawa, Nobutoshi Ito, Takeshi Tsubata: CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP. J. Exp. Med.. 2016.11; 213 (12): 2691-2706. ( PubMed , DOI )

Murota Y, Tabu K, and Taga T: Requirement of ABC transporter inhibition and Hoechst 33342 dye deprivation for the assessment of side population-defined C6 glioma stem cell metabolism using fluorescent probes. BMC Cancer. 2016.11; 16 847. ( PubMed , DOI )

Qixian Chen, Kensuke Osada, Zhishen Ge, Satoshi Uchida, Theofilus A. Tockary, Anjaneyulu Dirisala, Akitsugu Matsui, Kazuko Toh, Kaori M. Takeda, Xueying Liu, Takahiro Nomoto, Tekihiko Ishii, Makoto Oba, Yu Matsumoto, Kazunori Kataoka: Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting Biomaterials. 2016.10; 113 253-265. ( DOI )

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Okamoto-Uchida Yoshimi, Nakamura Ryosuke, Matsuzawa Yumiko, Soma Megumi, Kawakami Hiroshi, Ishii-Watabe Akiko, Nishimaki-Mogami Tomoko, Teshima Reiko, Saito Yoshiro: アレルゲンの固定化に起因するIgE結合および架橋に基づいたアレルギー検査の異なる結果(Different Results of IgE Binding- and Crosslinking-Based Allergy Tests Caused by Allergen Immobilization) Biological & Pharmaceutical Bulletin. 2016.10; 39 (10): 1662-1666. ( ichushi )

Termglinchan T, Hisamatsu S, Ohmori J, Suzumura H, Sumitomo N, Imataka G, Arisaka O, Murakami N, Minami N, Akihiko I, Sasaki M, Goto Y, Noguchi S, Nonaka I, Mitsuhashi S, Nishino I: Novel TK2 mutations as a cause of delayed muscle maturation in mtDNA depletion syndrome. Neurology. Genetics. 2016.10; 2 (5): e95. ( PubMed , DOI )

Reddy HM, Hamed SA, Lek M, Mitsuhashi S, Estrella E, Jones MD, Mahoney LJ, Duncan AR, Cho KA, Macarthur DG, Kunkel LM, Kang PB: Homozygous nonsense mutation in SGCA is a common cause of limb-girdle muscular dystrophy in Assiut, Egypt. Muscle & nerve. 2016.10; 54 (4): 690-5. ( PubMed , DOI )

Taniguchi JB, Kondo K, Fujita K, Chen X, Homma H, Sudo T, Mao Y, Watase K, Tanaka T, Tagawa K, Tamura T, Muramatsu SI, Okazawa H: RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair. Hum Mol Genet. 2016.10; 25 (20): 4432-4447. ( PubMed , DOI )

Yuya Hanazono, Kazuki Takeda, Kunio Miki: Structural studies of the N-terminal fragments of the WW domain: Insights into co-translational folding of a beta-sheet protein. Sci Rep. 2016.10; 6 34654. ( PubMed , DOI )

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Satoshi Uchida, Kentaro Hayakawa, Toru Ogata, Sakae Tanaka, Kazunori Kataoka, Keiji Itaka: Treatment of spinal cord injury by an advanced cell transplantation technology using brain-derived neurotrophic factor-transfected mesenchymal stem cell spheroids Biomaterials. 2016.09; 109 1-11. ( DOI )

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Imamura T, Fujita K, Tagawa K, Ikura T, Chen X, Homma H, Tamura T, Mao Y, Taniguchi JB, Motoki K, Nakabayashi M, Ito N, Yamada K, Tomii K, Okano H, Kaye J, Finkbeiner S, Okazawa H: Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries. Sci Rep. 2016.09; 6 33861. ( PubMed , DOI )

Masashi Kanayama, Keiko Danzaki, You-Wen He, Mari L Shinohara: Lung inflammation stalls Th17-cell migration en route to the central nervous system during the development of experimental autoimmune encephalomyelitis. Int. Immunol.. 2016.09; 28 (9): 463-469. ( PubMed , DOI )

Takayama K, Mitsuhashi S, Shin JY, Tanaka R, Fujii T, Tsuburaya R, Mukaida S, Noguchi S, Nonaka I, Nishino I: Japanese multiple epidermal growth factor 10 (MEGF10) myopathy with novel mutations: A phenotype-genotype correlation. Neuromuscular disorders : NMD. 2016.09; 26 (9): 604-9. ( PubMed , DOI )

Tomomi Imamura, Kyota Fujita, Kazuhiko Tagawa, Teikichi Ikura, Xigui Chen, Hidenori Homma, Takuya Tamura, Ying Mao, Juliana Bosso Taniguchi, Kazumi Motoki, Makoto Nakabayashi, Nobutoshi Ito, Kazunori Yamada, Kentaro Tomii, Hideyuki Okano, Julia Kaye, Steven Finkbeiner, Hitoshi Okazawa: Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries. Sci Rep. 2016.09; 6 33861. ( PubMed , DOI )

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Fujita K, Motoki K, Tagawa K, Chen X, Hama H, Nakajima K, Homma H, Tamura T, Watanabe H, Katsuno M, Matsumi C, Kajikawa M, Saito T, Saido T, Sobue G, Miyawaki A, Okazawa H: HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease. Sci Rep. 2016.08; 6 31895. ( PubMed , DOI )

S. Yoshikawa, M. Oh-hora, T. Adachi, Y. Yamanishi, H. Karasuyama: Stromal interaction molecule-1/2 plays essential role in basophil activation and development of IgE-mediated chronic allergic inflammation EUROPEAN JOURNAL OF IMMUNOLOGY. 2016.08; 46 99.

Shin Morioka, Kiyomi Nigorikawa, Junko Sasaki, Kaoru Hazeki, Yoshihiro Kasuu, Takehiko Sasaki, Osamu Hazeki: Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model. Innate Immun. 2016.08; 22 (6): 444-451. ( PubMed , DOI )

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Mizuguchi M, Obita T, Kajiyama A, Kozakai Y, Nakai T, Nabeshima Y, Okazawa H: Allosteric modulation of the binding affinity between PQBP1 and the spliceosomal protein U5-15kD. FEBS Lett. 2016.07; 590 (14): 2221-2231. ( PubMed , DOI )

Hamanaka K, Goto K, Arai M, Nagao K, Obuse C, Noguchi S, Hayashi YK, Mitsuhashi S, Nishino I: Corrigendum to "Clinical, muscle pathological, and genetic features of Japanese facioscapulohumeral muscular dystrophy 2 (FSHD2) patients with SMCHD1 mutations": [Neuromuscular Disorders 26/4-5 (2016) 300-308]. Neuromuscular disorders : NMD. 2016.07; 26 (7): 472. ( PubMed , DOI )

Kimura T, Wang L, Tabu K, Tsuda M, Tanino M, Maekawa A, Nishihara H, Hiraga H, Taga T, Oda Y, and Tanaka S: Identification and analysis of CXCR4-positive synovial sarcoma-initiating cells. Oncogene. 2016.07; 35 3932-3943.

Kimura T., Wang L., Tabu K., Tsuda M., Tanino M., Maekawa A., Nishihara H., Hiraga H., Taga T., Oda Y., Tanaka S.: Identification and analysis of CXCR4-positive synovial sarcoma-initiating cells ONCOGENE. 2016.07; 35 (30): 3932-3943. ( DOI )

Chin-Yu Lin, Federico Perche, Masaru Ikegami, Satoshi Uchida, Kazunori Kataoka, Keiji Itaka: Messenger RNA-based therapeutics for brain diseases: An animal study for augmenting clearance of beta-amyloid by intracerebral administration of neprilysin mRNA loaded in polyplex nanomicelles Journal of Controlled Release. 2016.06; 235 268-275. ( DOI )

Okubo M, Minami N, Goto K, Goto Y, Noguchi S, Mitsuhashi S, Nishino I: Genetic diagnosis of Duchenne/Becker muscular dystrophy using next-generation sequencing: validation analysis of DMD mutations. Journal of human genetics. 2016.06; 61 (6): 483-9. ( PubMed , DOI )

Takanori Chiba, Erika Ishihara, Norio Miyamura, Rika Narumi, Mihoko Kajita, Yasuyuki Fujita, Akira Suzuki, Yoshihiro Ogawa, Hiroshi Nishina: MDCK cells expressing constitutively active Yes-associated protein (YAP) undergo apical extrusion depending on neighboring cell status. Sci Rep. 2016.06; 6 28383. ( PubMed , DOI )

Shunta Nagashima, Junichi Maruyama, Shodai Kawano, Hiroaki Iwasa, Kentaro Nakagawa, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiroshi Nishina, Yutaka Hata: Validation of chemical compound library screening for transcriptional co-activator with PDZ-binding motif inhibitors using GFP-fused transcriptional co-activator with PDZ-binding motif. Cancer Sci.. 2016.06; 107 (6): 791-802. ( PubMed , DOI )

Yuya Hanazono, Kazuki Takeda, Kunio Miki: Characterization of the Nqo5 subunit of bacterial complex I in the isolated state. FEBS Open Bio. 2016.06; 6 (7): 687-695. ( PubMed , DOI )

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van den Boogaard ML, Lemmers RJLF, Balog J, Wohlgemuth M, Auranen M, Mitsuhashi S, van der Vliet PJ, Straasheijm KR, van den Akker RFP, Kriek M, Laurense-Bik MEY, Raz V, van Ostaijen-Ten Dam MM, Hansson KBM, van der Kooi EL, Kiuru-Enari S, Udd B, van Tol MJD, Nishino I, Tawil R, Tapscott SJ, van Engelen BGM, van der Maarel SM: Mutations in DNMT3B Modify Epigenetic Repression of the D4Z4 Repeat and the Penetrance of Facioscapulohumeral Dystrophy. American journal of human genetics. 2016.05; 98 (5): 1020-1029. ( PubMed , DOI )

Yoichi Asaoka, Yoko Nagai, Misako Namae, Makoto Furutani-Seiki, Hiroshi Nishina: SLC7 family transporters control the establishment of left-right asymmetry during organogenesis in medaka by activating mTOR signaling. Biochem. Biophys. Res. Commun.. 2016.05; 474 (1): 146-153. ( PubMed , DOI )

Tabu K, Muramatsu N, Mangani C, Wu M, Zhang R, Kimura T, Terashima K, Bizen N, Kimura R, Wang W, Murota Y, Kokubu Y, Nobuhisa I, Kagawa T, Kitabayashi I, Bradley M, and Taga T: A synthetic polymer scaffold reveals the self-maintenance strategies of rat glioma stem cells by organization of the advantageous niche. Stem Cells. 2016.05; 34 1151-1162. ( PubMed , DOI )

Toshiyasu Goto, Junhei Matsuzawa, Shun-Ichiro Iemura, Tohru Natsume, Hiroshi Shibuya: WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway. FEBS Lett.. 2016.05; 590 (9): 1291-1303. ( PubMed , DOI )

Valerie A Gerriets, Keiko Danzaki, Rigel J Kishton, William Eisner, Amanda G Nichols, Donte C Saucillo, Mari L Shinohara, Nancie J MacIver: Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity. European Journal of Immunology. 2016.05; 46 (8): 1970-1983. ( PubMed , DOI )

Jiajia Liu, Yong-Mei Guo, Nobuyuki Onai, Hideaki Ohyagi, Makoto Hirokawa, Naoto Takahashi, Hiroyuki Tagawa, Kumi Ubukawa, Isuzu Kobayashi, Hiroyuki Tezuka, Yoshihiro Minamiya, Toshiaki Ohteki, Kenichi Sawada: Cytosine-Phosphorothionate-Guanine Oligodeoxynucleotides Exacerbates Hemophagocytosis by Inducing Tumor Necrosis Factor-Alpha Production in Mice after Bone Marrow Transplantation. Biol Blood Marrow Transplant. 2016.04; 22 (4): 627-636. ( PubMed , DOI )

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Soichiro Yoshikawa, Takako Usami, Junichi Kikuta, Masaru Ishii, Tetsuo Sasano, Koji Sugiyama, Tetsushi Furukawa, Eiji Nakasho, Hiroshi Takayanagi, Thomas F Tedder, Hajime Karasuyama, Atsushi Miyawaki, Takahiro Adachi: Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset. Sci Rep. 2016.01; 6 18738. ( PubMed , DOI )

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Yoshimi Okamoto-Uchida, Ryosuke Nakamura, Yumiko Matsuzawa, Megumi Soma, Hiroshi Kawakami, Akiko Ishii-Watabe, Tomoko Nishimaki-Mogami, Reiko Teshima, Yoshiro Saito: Different Results of IgE Binding- and Crosslinking-Based Allergy Tests Caused by Allergen Immobilization. Biol Pharm Bull. 2016; 39 (10): 1662-1666. ( PubMed , DOI )

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Isao Kii, Yuto Sumida, Toshiyasu Goto, Rie Sonamoto, Yukiko Okuno, Suguru Yoshida, Tomoe Kato-Sumida, Yuka Koike, Minako Abe, Yosuke Nonaka, Teikichi Ikura, Nobutoshi Ito, Hiroshi Shibuya, Takamitsu Hosoya, Masatoshi Hagiwara: Selective inhibition of the kinase DYRK1A by targeting its folding process. Nat Commun. 2016; 7 11391. ( PubMed , DOI )

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Satoshi Uchida, Hiroaki Kinoh, Takehiko Ishii, Akitsugu Matsui, Theofilus Agrios Tockary, Kaori Machitani Takeda, Hirokuni Uchida, Kensuke Osada, Keiji Itaka, Kazunori Kataoka: Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety Biomaterials. 2015.12; 82 221-228. ( DOI )

齋藤 清香, 信久 幾夫, Anani Maha, 原田 果歩, 高橋 聡美, 田賀 哲也: マウス胎生期成体型造血の場AGM領域の未分化血球系細胞塊におけるSox17-Notch1-Hes1経路による未分化性維持 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015.12; 88回・38回 [1P0983]. ( ichushi )

椨 康一, 村松 希美, 田賀 哲也: 人工ニッチポリマーの応用による鉄貯蔵/腫瘍随伴マクロファージの誘導を介するグリオーマ幹細胞の環境適応戦略の解明 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015.12; 88回・38回 [1P1039]. ( ichushi )

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Jun Makino, Horacio Cabral, Yutaka Miura, Yu Matsumoto, Ming Wang, Hiroaki Kinoh, Yuki Mochida, Nobuhiro Nishiyama, Kazunori Kataoka: cRGD-installed polymeric micelles loading platinum anticancer drugs enable cooperative treatment against lymph node metastasis. Journal of Controlled Release. 2015.12; 220 783-791. ( DOI )

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Yusuke Watarai, Michiyasu Ishizawa, Teikichi Ikura, Flavia C M Zacconi, Shigeyuki Uno, Nobutoshi Ito, Antonio Mouriño, Hiroaki Tokiwa, Makoto Makishima, Sachiko Yamada: Synthesis, Biological Activities, and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds. J. Med. Chem.. 2015.12; 58 (24): 9510-9521. ( PubMed , DOI )

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Omer Faruk Mutaf, Akihiro Kishimura, Yuki Mochida, Ahram Kim, Kazunori Kataoka: Induction of Secondary Structure through Micellization of an Oppositely Charged Pair of Homochiral Block‐and Homopolypeptides in an Aqueous Medium. Macromolar Rapid Communications. 2015.11; 36 (22): 1958-1964. ( DOI )

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Yasuaki Anami, Yuta Sakamaki, Toshimasa Itoh, Yuka Inaba, Makoto Nakabayashi, Teikichi Ikura, Nobutoshi Ito, Keiko Yamamoto: Fine tuning of agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity. Bioorg. Med. Chem.. 2015.11; 23 (22): 7274-7281. ( PubMed , DOI )

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Nobuhisa Ikuo, Saito Kiyoka, Takahashi Satomi, Harada Kaho, Anani Maha, Taga Tetsuya: 造血と免疫系微小環境　Sox17は、Notchシグナル伝達を介し、大動脈-性腺-中腎領域における大動脈内造血細胞クラスタの幹細胞集団を維持する(Hematopoiesis and microenvironments for immune system　Sox17 maintains the stem cell population of intra-aortic hematopoietic cell clusters in the aorta-gonad-mesonephros region through Notch signaling) 日本免疫学会総会・学術集会記録. 2015.10; 44 (Proceedings): 147. ( ichushi )

Izumi R, Warita H, Niihori T, Takahashi T, Tateyama M, Suzuki N, Nishiyama A, Shirota M, Funayama R, Nakayama K, Mitsuhashi S, Nishino I, Aoki Y, Aoki M: Isolated inclusion body myopathy caused by a multisystem proteinopathy-linked hnRNPA1 mutation. Neurology. Genetics. 2015.10; 1 (3): e23. ( PubMed , DOI )

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Masaki Kinoshita, Daisuke Shimosato, Mariko Yamane, Hitoshi Niwa: Sox7 is dispensable for primitive endoderm differentiation from mouse ES cells BMC DEVELOPMENTAL BIOLOGY. 2015.10; 15 37. ( PubMed , DOI )

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Kaniwa Nahoko, Ueta Mayumi, Nakamura Ryosuke, Okamoto-Uchida Yoshimi, Sugiyama Emiko, Maekawa Keiko, Takahashi Yukitoshi, Furuya Hirokazu, Yagami Akiko, Matsukura Setsuko, Ikezawa Zenro, Matsunaga Kayoko, Sotozono Chie, Aihara Michiko, Kinoshita Shigeru, Saito Yoshiro: Stevens-Johnson症候群/中毒性表皮壊死症の日本人患者において重症眼表面疾患を引き起こした薬物(Drugs causing severe ocular surface involvements in Japanese patients with Stevens-Johnson syndrome/toxic epidermal necrolysis) Allergology International. 2015.10; 64 (4): 379-381. ( ichushi )

Tsutomu Endo, Koyu Ito, Junko Morimoto, Masashi Kanayama, Daichi Ota, Masahiro Ikesue, Shigeyuki Kon, Daisuke Takahashi, Tomohiro Onodera, Norimasa Iwasaki, Toshimitsu Uede: Syndecan 4 Regulation of the Development of Autoimmune Arthritis in Mice by Modulating B Cell Migration and Germinal Center Formation. Arthritis & rheumatology (Hoboken, N.J.). 2015.09; 67 (9): 2512-2522. ( PubMed , DOI )

Saito Kiyoka, Nobuhisa Ikuo, Anani Maha, Harada Kaho, Takahashi Satomi, Taga Tetsuya: MAINTENANCE OF HEMATOPOIETIC STEM AND PROGENITOR CELL PHENOTYPE OF INTRA-AORTIC CELL CLUSTERS IN THE AGM REGION THROUGH THE SOX17-NOTCH1-HES1 AXIS EXPERIMENTAL HEMATOLOGY. 2015.09; 43 (9): S92.

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Tomoyuki Okuda, Yumiko Suzuki, Yuko Kobayashi, Takehiko Ishii, Satoshi Uchida, Keiji Itaka, Kazunori Kataoka, Hirokazu Okamoto: Development of biodegradable polycation-based inhalable dry gene powders by spray freeze drying Pharmaceutics. 2015.08; 7 (3): 233-254. ( DOI )

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Hikaru Ito, Kyota Fujita, Kazuhiko Tagawa, Xigui Chen, Hidenori Homma, Toshikazu Sasabe, Jun Shimizu, Shigeomi Shimizu, Takuya Tamura, Shin-ichi Muramatsu, Hitoshi Okazawa: HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice. EMBO Mol Med. 2015.01; 7 (1): 78-101. ( PubMed , DOI )

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Satoshi Toda, Chihiro Nishi, Yuichi Yanagihashi, Katsumori Segawa, Shigekazu Nagata: Clearance of Apoptotic Cells and Pyrenocytes. Curr Top Dev Biol. 2015; 114 267-295. ( PubMed , DOI )

Gerald R V Hammond, Shunsuke Takasuga, Takehiko Sasaki, Tamas Balla: The ML1Nx2 Phosphatidylinositol 3,5-Bisphosphate Probe Shows Poor Selectivity in Cells. PLoS ONE. 2015; 10 (10): e0139957. ( PubMed , DOI )

Liang WC, Zhu W, Mitsuhashi S, Noguchi S, Sacher M, Ogawa M, Shih HH, Jong YJ, Nishino I: Congenital muscular dystrophy with fatty liver and infantile-onset cataract caused by TRAPPC11 mutations: broadening of the phenotype. Skeletal muscle. 2015; 5 29. ( PubMed , DOI )

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Maekawa K, Nakamura R, Kaniwa N, Mizusawa S, Kitamoto A, Kitamoto T, Ukaji M, Matsuzawa Y, Sugiyama E, Uchida Y, Kurose K, Ueta M, Sotozono C, Ikeda H, Yagami A, Matsukura S, Kinoshita S, Muramatsu M, Ikezawa Z, Sekine A, Furuya H, Takahashi Y, Matsunaga K, Aihara M, Saito Y; Japan Pharmacogenomics Data Science Consortium.: Development of a simple genotyping method for the HLA-A*31:01-tagging SNP in Japanese. Pharmacogenomics. 2015; 16 (15): 1689-1699. ( PubMed )

Nabeshima Y, Mizuguchi M, Kajiyama A, Okazawa H: Segmental isotope-labeling of the intrinsically disordered protein PQBP1. FEBS Letters. 2014.12; 588 (24): 4583-4589. ( PubMed , DOI )

Shigeyuki Kon, Yosuke Nakayama, Naoki Matsumoto, Koyu Ito, Masashi Kanayama, Chiemi Kimura, Hitomi Kouro, Dai Ashitomi, Tadashi Matsuda, Toshimitsu Uede: A novel cryptic binding motif, LRSKSRSFQVSDEQY, in the C-terminal fragment of MMP-3/7-cleaved osteopontin as a novel ligand for α9β1 integrin is involved in the anti-type II collagen antibody-induced arthritis. PLoS ONE. 2014.12; 9 (12): e116210. ( PubMed , DOI )

Daichi Ota, Masashi Kanayama, Yutaka Matsui, Koyu Ito, Naoyoshi Maeda, Goro Kutomi, Koichi Hirata, Toshihiko Torigoe, Noriyuki Sato, Akinori Takaoka, Ann F Chambers, Junko Morimoto, Toshimitsu Uede: Tumor-α9β1 integrin-mediated signaling induces breast cancer growth and lymphatic metastasis via the recruitment of cancer-associated fibroblasts. J. Mol. Med.. 2014.12; 92 (12): 1271-1281. ( PubMed , DOI )

Y. Fujioka, M. Tsuda, A. Nanbo, T. Hattori, J. Sasaki, T. Sasaki, T. Miyazaki, Y. Ohba: Calcium signaling mediated influenza virus entry into host cells. MOLECULAR BIOLOGY OF THE CELL. 2014.12; 25

Y. Fujioka, M. Tsuda, A. Nanbo, T. Hattori, J. Sasaki, T. Sasaki, T. Miyazaki, Y. Ohba: Calcium signaling mediated influenza virus entry into host cells. MOLECULAR BIOLOGY OF THE CELL. 2014.12; 25

Pregnenolone Functions in Centriole Cohesion during Mitosis 2014.12; 21 (12): 1707-1721. ( PubMed , DOI )

Shiraishi R, Tamura T, Sone M, Okazawa H: Systematic analysis of fly models with multiple drivers reveals different effects of ataxin-1 and huntingtin in neuron subtype-specific expression. PLoS ONE. 2014.12; 9 (12): e116567. ( PubMed , DOI )

Hiroyuki Takatsu, Gaku Tanaka, Katsumori Segawa, Jun Suzuki, Shigekazu Nagata, Kazuhisa Nakayama, Hye-Won Shin: Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane. J Biol Chem. 2014.11; 289 (48): 33543-33556. ( PubMed , DOI )

Kentaro Hayakawa, Satoshi Uchida, Toru Ogata, Sakae Tanaka, Kazunori Kataoka, Keiji Itaka: Intrathecal injection of a therapeutic gene-containing polyplex to treat spinal cord injury Journal of Controlled Release. 2014.11; 197 1-9. ( DOI )

Inagaki Tetsunori, Kato Kiyoko, Kusunoki Soshi, Tabu Koichi, Okabe Hitomi, Yamada Izumi, Taga Tetsuya, Matsumoto Akemi, Takezawa Toshiaki, Makino Shintaro, Takeda Satoru: IDENTIFICATION AND CHARACTERIZATION OF HTR-8/SVNEO SP CELLS. PLACENTA. 2014.10; 35 (10): A6.

Draper I, Mahoney LJ, Mitsuhashi S, Pacak CA, Salomon RN, Kang PB: Silencing of drpr leads to muscle and brain degeneration in adult Drosophila. The American journal of pathology. 2014.10; 184 (10): 2653-61. ( PubMed , DOI )

椨 康一, 國分 康博, 田賀 哲也: 癌幹細胞ニッチの自己構築における自発的オートスキジスの関与の検討(Autoschizic cancer cell death and its implications to cancer stem cell niche) 日本癌学会総会記事. 2014.09; 73回 P-1167. ( ichushi )

Tagawa, K., Homma, H., Saito, A., Fujita, K., Chen, X., Imoto, S., Oka, T., Ito, H., Motoki, K., Yoshida, C., Hatsuta, H., Murayama, S., Iwatsubo, T., Miyano, S., Okazawa, H.: Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain. Hum Mol Genet. 2014.09; ( PubMed , DOI )

王 文茜, 椨 康一, 萩谷 祐一郎, 小倉 俊一郎, 田賀 哲也: 非癌幹細胞由来ヘムの赤血球分化へ与える影響(Roles of cancer-derived heme in erythropoiesis: implications for erythroid niche for cancer stem cells) 日本癌学会総会記事. 2014.09; 73回 P-1168. ( ichushi )

Nobuyuki Shimizu, Shizuka Ishitani, Atsushi Sato, Hiroshi Shibuya, Tohru Ishitani: Hipk2 and PP1c cooperate to maintain Dvl protein levels required for Wnt signal transduction. Cell Rep. 2014.09; 8 (5): 1391-1404. ( PubMed , DOI )

國分 康博, 椨 康一, 王 文茜, バグダディ・ムハンマド , 地主 将久, 田賀 哲也: C6グリオーマ癌幹細胞由来GM-CSFはCD11c high CD204(+)腫瘍促進性マクロファージを誘導する(C6 glioma stem cell-derived GM-CSF induces CD11chighCD204(+) protumoral macrophages) 日本癌学会総会記事. 2014.09; 73回 P-1176. ( ichushi )

Anani Maha, Nobuhisa Ikuo, Osawa Mitsujiro, Iwama Atsushi, Harada Kaho, Saito Kiyoka, Taga Tetsuya: 骨髄に限定された分化能を持つ調節因子候補としてのSox17(Sox17 as a candidate regulator of myeloid restricted differentiation potential) Development, Growth & Differentiation. 2014.08; 56 (6): 469-479. ( ichushi )

S. Quader, H. Cabral, Y. Mochida, T. Ishii, X. Liu, K. Toh, H. Kinoh, Y. Miura, N. Nishiyama, K. Kataoka: Selective intracellular delivery of proteasome inhibitors through pH-sensitive polymeric micelles directed to efficient antitumor therapy. Journal of Controlled Release. 2014.08; 188 67-77. ( DOI )

Yamamoto M, Onogi H, Kii I, Yoshida S, Iida K, Sakai H, Abe M, Tsubota T, Ito N, Hosoya T, Hagiwara M: CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses. J Clin Invest. 2014.08; 124 (8): 3479-3488. ( PubMed , DOI )

Anani Maha, Nobuhisa Ikuo, Osawa Mitsujiro, Iwama Atsushi, Harada Kaho, Saito Kiyoka, Taga Tetsuya: Sox17 as a candidate regulator of myeloid restricted differentiation potential. Dev Growth Differ. 2014.08; 56 (6): 469-479. ( PubMed , DOI )

Ito, H., Shiwaku, H., Yoshida, C., Homma, H., Luo, H., Chen, X., Fujita, K., Musante, L., Fischer, U., Frints, S G M., Romano, C., Ikeuchi, Y., Shimamura, T., Imoto, S., Miyano, S., Muramatsu, S-I., Kawauchi, T., Hoshino, M., Sudol, M., Arumughan, A., Wanker, E E., Rich, T., Schwartz, C., Matsuzaki, F., Bonni, A., Kalscheuer, V M., Okazawa, H.: In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells. Mol Psychiatry. 2014.07; 20 (4): 459-71. ( PubMed , DOI )

Tomonori Ayukawa, Masakazu Akiyama, Jennifer L Mummery-Widmer, Thomas Stoeger, Junko Sasaki, Juergen A Knoblich, Haruki Senoo, Takehiko Sasaki, Masakazu Yamazaki: Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in Drosophila. Cell Rep. 2014.07; 8 (2): 610-621. ( PubMed , DOI )

Nobuyuki Onai, Toshiaki Ohteki: Bipotent or Oligopotent? A Macrophage and DC Progenitor Revisited. Immunity. 2014.07; 41 (1): 5-7. ( PubMed , DOI )

A Yokota-Nakatsuma, H Takeuchi, Y Ohoka, C Kato, S-Y Song, T Hoshino, H Yagita, T Ohteki, M Iwata: Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells. Mucosal Immunol. 2014.07; 7 (4): 786-801. ( PubMed , DOI )

Katsumori Segawa, Sachiko Kurata, Yuichi Yanagihashi, Thijn R Brummelkamp, Fumihiko Matsuda, Shigekazu Nagata: Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure. Science. 2014.06; 344 (6188): 1164-1168. ( PubMed , DOI )

Satoshi Toda, Katsumori Segawa, Shigekazu Nagata: MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands. Blood. 2014.06; 123 (25): 3963-3971. ( PubMed , DOI )

Yuki Mochida, Horacio Cabral, Yutaka Miura, Francesco Albertini, Shigeto Fukushima, Kensuke Osada, Nobuhiro Nishiyama, Kazunori Kataoka: Bundled Assembly of Helical Nanostructures in Polymeric Micelles Loaded with Platinum Drugs Enhancing Therapeutic Efficiency against Pancreatic Tumor. ACS Nano. 2014.06; 8 (7): 6724-6738. ( DOI )

Shuji Terai, Taro Takami, Naoki Yamamoto, Koichi Fujisawa, Tsuyoshi Ishikawa, Yohei Urata, Haruko Tanimoto, Takuya Iwamoto, Yuko Mizunaga, Takashi Matsuda, Takashi Oono, Miho Marumoto, Guzel Burganova, Luiz Fernando Quintanilha, Isao Hidaka, Yoshio Marumoto, Issei Saeki, Koichi Uchida, Takahiro Yamasaki, Kenji Tani, Yasuho Taura, Yasuhiko Fujii, Hiroshi Nishina, Kiwamu Okita, Isao Sakaida: Status and prospects of liver cirrhosis treatment by using bone marrow-derived cells and mesenchymal cells. Tissue Eng Part B Rev. 2014.06; 20 (3): 206-210. ( PubMed , DOI )

Bizen N, Inoue T, Shimizu T, Tabu K, Kagawa T, and Taga T: A growth-promoting signaling component cyclin D1 in neural stem cells has antiastrogliogenic function to execute self-renewal. Stem Cells. 2014.06; 32 (6): 1602-1615. ( PubMed , DOI )

Nobuhisa Ikuo, Osawa Mitsujiro, Uemura Mami, Kishikawa Yoko, Anani Maha, Harada Kaho, Takagi Haruna, Saito Kiyoka, Kanai-Azuma Masami, Kanai Yoshiakira, Iwama Atsushi, Taga Tetsuya: Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters. Mol Cell Biol. 2014.06; 34 (11): 1976-1990. ( PubMed , DOI )

Khajuria A., Tabu K., Taga T.: Glioma stem cells exploit host astrocytes to enhance tumour migratory and invasive capacity BRITISH JOURNAL OF SURGERY. 2014.05; 101 36-37.

Zeyu Yang, Kentaro Nakagawa, Aradhan Sarkar, Junichi Maruyama, Hiroaki Iwasa, Yijun Bao, Mari Ishigami-Yuasa, Shigeru Ito, Hiroyuki Kagechika, Shoji Hata, Hiroshi Nishina, Shinya Abe, Masanobu Kitagawa, Yutaka Hata: Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model. Mol. Cell. Biol.. 2014.05; 34 (9): 1607-1621. ( PubMed , DOI )

Kudo Takeru, Ishizawa Michiyasu, Maekawa Kazuki, Nakabayashi Makoto, Watarai Yusuke, Uchida Hikaru, Tokiwa Hiroaki, Ikura Teikichi, Ito Nobutoshi, Makishima Makoto, Yamada Sachiko: Combination of triple bond and adamantane ring on the vitamin D side chain produced partial agonists for vitamin D receptor. J Med Chem. 2014.05; 57 (10): 4073-4087. ( PubMed , DOI )

Chihiro Nishi, Satoshi Toda, Katsumori Segawa, Shigekazu Nagata: Tim4- and MerTK-mediated engulfment of apoptotic cells by mouse resident peritoneal macrophages. Mol Cell Biol. 2014.04; 34 (8): 1512-1520. ( PubMed , DOI )

Anjaneyulu Dirisala, Kensuke Osada, Qixian Chen, Theofilus A. Tockary, Kaori Machitani, Shigehito Osawa, Xueying Liu, Takehiko Ishii, Kanjiro Miyata, Makoto Oba, Satoshi Uchida, Keiji Itaka, Kazunori Kataoka: Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors Biomaterials. 2014.04; 35 (20): 5359-5368. ( DOI )

Shunsuke Ito, Mariko Yamane, Satoshi Ohtsuka, Hitoshi Niwa: The C-terminal region of Xpc is dispensable for the transcriptional activity of Oct3/4 in mouse embryonic stem cells FEBS LETTERS. 2014.04; 588 (7): 1128-1135. ( PubMed , DOI )

Keita Nakanaga, Kotaro Hama, Kuniyuki Kano, Takanao Sato, Hiroshi Yukiura, Asuka Inoue, Daisuke Saigusa, Hidetoshi Tokuyama, Yoshihisa Tomioka, Hiroshi Nishina, Atsuo Kawahara, Junken Aoki: Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo. J. Biochem.. 2014.04; 155 (4): 235-241. ( PubMed , DOI )

Mizuguchi M, Obita T, Serita T, Kojima R, Nabeshima Y, Okazawa H: Mutations in the PQBP1 gene prevent its interaction with the spliceosomal protein U5-15 kD. Nat Commun. 2014.04; 5 3822. ( PubMed , DOI )

Tsuyoshi Asano, Norimasa Iwasaki, Shigeyuki Kon, Masashi Kanayama, Junko Morimoto, Akio Minami, Toshimitsu Uede: α9β1 integrin acts as a critical intrinsic regulator of human rheumatoid arthritis. Rheumatology (Oxford). 2014.03; 53 (3): 415-424. ( PubMed , DOI )

Kazuya Nagata, Keiji Itaka, Miyuki Baba, Satoshi Uchida, Takehiko Ishii, Kazunori Kataoka: Muscle-targeted hydrodynamic gene introduction of insulin-like growth factor-1 using polyplex nanomicelle to treat peripheral nerve injury Journal of Controlled Release. 2014.03; 183 27-34. ( DOI )

Barclay SS, Tamura T, Ito H, Fujita K, Tagawa K, Shimamura T, Katsuta A, Shiwaku H, Sone M, Imoto S, Miyano S, Okazawa H: Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1. Hum Mol Genet. 2014.03; 23 (5): 1345-1364. ( PubMed , DOI )

Mingguo Huang, Shintaro Narita, Takamitsu Inoue, Norihiko Tsuchiya, Shigeru Satoh, Hiroshi Nanjo, Takehiko Sasaki, Tomonori Habuchi: Diet-induced macrophage inhibitory cytokine 1 promotes prostate cancer progression ENDOCRINE-RELATED CANCER. 2014.02; 21 (1): 39-50. ( PubMed , DOI )

Furusawa Yoshihiko, Mitsuhashi Satomi, Mori-Yoshimura Madoka, Shimada Yohta, Yamamoto Toshiyuki, Shibuya Makoto, Shimizu Jun, Ohashi Toya, Saito Yuko, Nishino Ichizo, Oya Yasushi, Murata Miho: 酵素補充療法から4年後に発症した遅発型ポンぺ病　剖検例(Late-onset Pompe disease after 4 years of enzyme replacement therapy: An autopsy case) Neurology and Clinical Neuroscience. 2014.01; 2 (1): 7-9. ( ichushi )

Zhishen Ge, Qixian Chen, Kensuke Osada, Xueying Liu, Theofilus A. Tockary, Satoshi Uchida, Anjaneyulu Dirisala, Takehiko Ishii, Takahiro Nomoto, Kazuko Toh, Yu Matsumoto, Makoto Oba, Mitsunobu R. Kano, Keiji Itaka, Kazunori Kataoka: Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors Biomaterials. 2014.01; 35 (10): 3416-3426. ( DOI )

Inhibition of endocytic vesicle fusion by Plk1-mediated phosphorylation of vimentin during mitosis 2014.01; 13 (1): 126-137. ( PubMed , DOI )

Tadanori Shimomura, Norio Miyamura, Shoji Hata, Ryota Miura, Jun Hirayama, Hiroshi Nishina: The PDZ-binding motif of Yes-associated protein is required for its co-activation of TEAD-mediated CTGF transcription and oncogenic cell transforming activity. Biochem. Biophys. Res. Commun.. 2014.01; 443 (3): 917-923. ( PubMed , DOI )

Katsumori Segawa, Jun Suzuki, Shigekazu Nagata: Flippases and scramblases in the plasma membrane. Cell Cycle. 2014; 13 (19): 2990-2991. ( PubMed , DOI )

Nakamura Ryotaro, Takasuga Shunsuke, Horie Yasuo, SASAKI Takehiko: ALTERATIONS IN INTESTINAL PERMEABILITY CAUSE COLONIC INFLAMMATION AND FIBROSIS IN TYPE Ⅲ PHOSPHATIDYLINOSITOL PHOSPHATE KINASE-DEFICIENT MICE 秋田医学. 2014; 41 (3): 129-135.

Yoichi Asaoka, Shoji Hata, Misako Namae, Makoto Furutani-Seiki, Hiroshi Nishina: The Hippo pathway controls a switch between retinal progenitor cell proliferation and photoreceptor cell differentiation in zebrafish. PLoS ONE. 2014; 9 (5): e97365. ( PubMed , DOI )

Satoshi Uchida, Keiji Itaka, Takahiro Nomoto, Taisuke Endo, Yu Matsumoto, Takehiko Ishii, Kazunori Kataoka: An injectable spheroid system with genetic modification for cell transplantation therapy Biomaterials. 2013.12; 35 (8): 2499-2506. ( DOI )

Mitsuhashi S, Boyden SE, Estrella EA, Jones TI, Rahimov F, Yu TW, Darras BT, Amato AA, Folkerth RD, Jones PL, Kunkel LM, Kang PB: Exome sequencing identifies a novel SMCHD1 mutation in facioscapulohumeral muscular dystrophy 2. Neuromuscular disorders : NMD. 2013.12; 23 (12): 975-80. ( PubMed , DOI )

Toshiyasu Goto, Atsushi Sato, Shungo Adachi, Shun-ichiro Iemura, Tohru Natsume, Hiroshi Shibuya: IQGAP1 protein regulates nuclear localization of β-catenin via importin-β5 protein in Wnt signaling. J. Biol. Chem.. 2013.12; 288 (51): 36351-36360. ( PubMed , DOI )

Yoichiro Fujioka, Masumi Tsuda, Asuka Nanbo, Tomoe Hattori, Junko Sasaki, Takehiko Sasaki, Tadaaki Miyazaki, Yusuke Ohba: A Ca(2+)-dependent signalling circuit regulates influenza A virus internalization and infection. Nat Commun. 2013.11; 4 2763. ( PubMed , DOI )

Kenjiro Adachi, Itoshi Nikaido, Hiroshi Ohta, Satoshi Ohtsuka, Hiroki Ura, Mitsutaka Kadota, Teruhiko Wakayama, Hiroki R. Ueda, Hitoshi Niwa: Context-Dependent Wiring of Sox2 Regulatory Networks for Self-Renewal of Embryonic and Trophoblast Stem Cells MOLECULAR CELL. 2013.11; 52 (3): 380-392. ( PubMed , DOI )

Nobuhisa Ikuo, Osawa Mitsujiro, Harada Kaho, Anani Maha, Saito Kiyoka, Takagi Haruna, Iwama Atsushi, Taga Tetsuya, Uemura Mami, Kanai Yoshiaki, Kanai-Azuma Masami: Sox17形質導入細胞移植マウスの骨髄細胞を移植したレシピエントの分析(Analysis of recipients transplantated with the bone marrow cells of Sox17-transduced cells-transplanted mice) 日本免疫学会総会・学術集会記録. 2013.11; 42 (Proceedings): 70. ( ichushi )

椨 康一, 村松 希美, 田賀 哲也: 人工ポリマーを用いたC6グリオーマ幹細胞ニッチの同定(Polymer-based identification of cancer stem cell niche for C6 glioma) 日本癌学会総会記事. 2013.10; 72回 141. ( ichushi )

Mitsuhashi S, Nishino I: Megaconial congenital muscular dystrophy due to loss-of-function mutations in choline kinase β. Current opinion in neurology. 2013.10; 26 (5): 536-43. ( PubMed , DOI )

Masaki Shigeta, Satoshi Ohtsuka, Satomi Nishikawa-Torikai, Mariko Yamane, Setsuko Fujii, Kazuhiro Murakami, Hitoshi Niwa: Maintenance of pluripotency in mouse ES cells without Trp53 Scientific Reports. 2013.10; 3 2944. ( PubMed , DOI )

Mitsuhashi S, Mitsuhashi H, Alexander MS, Sugimoto H, Kang PB: Cysteine mutations cause defective tyrosine phosphorylation in MEGF10 myopathy. FEBS letters. 2013.09; 587 (18): 2952-7. ( PubMed , DOI )

Ikeuchi Y, de la Torre-Ubieta L, Matsuda T, Steen H, Okazawa H, Bonni A: The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling link that orchestrates ciliary morphogenesis in postmitotic neurons. Cell Rep. 2013.09; 4 (5): 879-889. ( PubMed , DOI )

Ikura Teikichi, Ito Nobutoshi: Peptidyl-prolyl isomerase activity of FK506 binding protein 12 prevents tau peptide from aggregating. Protein Eng Des Sel. 2013.09; 26 (9): 539-546. ( PubMed , DOI )

Nakabayashi Makoto, Tsukahara Yoshito, Iwasaki-Miyamoto Yukiko, Mihori-Shimazaki Mika, Yamada Sachiko, Inaba Satomi, Oda Masayuki, Shimizu Masato, Makishima Makoto, Tokiwa Hiroaki, Ikura Teikichi, Ito Nobutoshi: Crystal structures of hereditary vitamin D-resistant rickets-associated vitamin D receptor mutants R270L and W282R bound to 1,25-dihydroxyvitamin D3 and synthetic ligands. J Med Chem. 2013.09; 56 (17): 6745-6760. ( PubMed , DOI )

Takayuki Sato, Toshio Kitawaki, Haruyuki Fujita, Makoto Iwata, Tomonori Iyoda, Kayo Inaba, Toshiaki Ohteki, Suguru Hasegawa, Kenji Kawada, Yoshiharu Sakai, Hiroki Ikeuchi, Hiroshi Nakase, Akira Niwa, Akifumi Takaori-Kondo, Norimitsu Kadowaki: Human CD1c⁺ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D₃. J Immunol. 2013.09; 191 (6): 3152-3160. ( PubMed , DOI )

Hideaki Ohyagi, Nobuyuki Onai, Taku Sato, Satoshi Yotsumoto, Jiajia Liu, Hisaya Akiba, Hideo Yagita, Koji Atarashi, Kenya Honda, Axel Roers, Werner Müller, Kazutaka Kurabayashi, Mayuka Hosoi-Amaike, Naoto Takahashi, Makoto Hirokawa, Kouji Matsushima, Kenichi Sawada, Toshiaki Ohteki: Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses. Immunity. 2013.09; 39 (3): 584-598. ( PubMed , DOI )

Theofilus A. Tockary, Kensuke Osada, Qixian Chen, Kaori Machitani, Anjaneyulu Dirisala, Satoshi Uchida, Takahiro Nomoto, Kazuko Toh, Yu Matsumoto, Keiji Itaka, Koji Nitta, Kuniaki Nagayama, Kazunori Kataoka: Tethered PEG Crowdedness Determining Shape and Blood Circulation Profile of Polyplex Micelle Gene Carriers Macromolecules. 2013.08; 46 (16): 6585-6592. ( DOI )

Chou PC, Liang WC, Nonaka I, Mitsuhashi S, Nishino I, Jong YJ: Intranuclear rods myopathy with autonomic dysfunction. Brain & development. 2013.08; 35 (7): 686-9. ( PubMed , DOI )

Higo K, Ikura T, Oda M, Morii H, Takahashi J, Abe R, Ito N: High resolution crystal structure of the Grb2 SH2 domain with a phosphopeptide derived from CD28 PLoS One. 2013.08; 8 (9): e74482. ( DOI )

Shiwaku H, Yagishita S, Eishi Y, Okazawa H: Bergmann glia are reduced in spinocerebellar ataxia type 1. Neuroreport. 2013.08; 24 (11): 620-625. ( PubMed , DOI )

Masuno Hiroyuki, Ikura Teikichi, Morizono Daisuke, Orita Isamu, Yamada Sachiko, Shimizu Masato, Ito Nobutoshi: Crystal structures of complexes of vitamin D receptor ligand-binding domain with lithocholic acid derivatives. J Lipid Res. 2013.08; 54 (8): 2206-2213. ( PubMed , DOI )

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Yoshimoto Nobuko, Sakamaki Yuta, Haeta Minoru, Kato Akira, Inaba Yuka, Itoh Toshimasa, Nakabayashi Makoto, Ito Nobutoshi, Yamamoto Keiko: Butyl pocket formation in the vitamin D receptor strongly affects the agonistic or antagonistic behavior of ligands. J Med Chem. 2012.05; 55 (9): 4373-4381. ( PubMed , DOI )

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Tamashiro Tomonari, Tanabe Yoichi, Ikura Teikichi, Ito Nobutoshi, Oda Masayuki: Critical roles of Asp270 and Trp273 in the alpha-repeat of the carbohydrate-binding module of endo-1,3-beta-glucanase for laminarin-binding avidity. Glycoconj J. 2012.01; 29 (1): 77-85. ( PubMed , DOI )

Nobuyuki Kawamura, Ge-Hong Sun-Wada, Minako Aoyama, Akihiro Harada, Shunsuke Takasuga, Takehiko Sasaki, Yoh Wada: Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos. Nat Commun. 2012; 3 1071. ( PubMed , DOI )

Takahashi M, Saitou N: Identification and characterization of lineage-specific highly conserved noncoding sequences in mammalian genomes. Genome Biology and Evolution. 2012; 4 641-657.

Tokiwa Yamasaki, Hiroshi Kawasaki, Hiroshi Nishina: Diverse Roles of JNK and MKK Pathways in the Brain. J Signal Transduct. 2012; 2012 459265. ( PubMed , DOI )

Yuko Mizunaga, Shuji Terai, Naoki Yamamoto, Koichi Uchida, Takahiro Yamasaki, Hiroshi Nishina, Yusuke Fujita, Koh Shinoda, Yoshihiko Hamamoto, Isao Sakaida: Granulocyte colony-stimulating factor and interleukin-1β are important cytokines in repair of the cirrhotic liver after bone marrow cell infusion: comparison of humans and model mice. Cell Transplant. 2012; 21 (11): 2363-2375. ( PubMed , DOI )

ABL1 Joins the Cadre of Spindle Orientation Machinery 2012; 37 (2): 81-87. ( PubMed , DOI )

Tadashi Yokoi, Yuko Seko, Tae Yokoi, Hatsune Makino, Shin Hatou, Masakazu Yamada, Tohru Kiyono, Akihiro Umezawa, Hiroshi Nishina, Noriyuki Azuma: Establishment of functioning human corneal endothelial cell line with high growth potential. PLoS ONE. 2012; 7 (1): e29677. ( PubMed , DOI )

Hitomi Yuki, Adachi Takahiro, Tsuchiya Naoyuki, Honda Zen-Ichiro, Tokunaga Katsushi, Tsubata Takeshi: Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum. BMC Immunol. 2012; 13 72. ( PubMed , DOI )

Tomoya Suma, Kanjiro Miyata, Takehiko Ishii, Satoshi Uchida, Hirokuni Uchida, Keiji Itaka, Nobuhiro Nishiyama, Kazunori Kataoka: Enhanced stability and gene silencing ability of siRNA-loaded polyion complexes formulated from polyaspartamide derivatives with a repetitive array of amino groups in the side chain Biomaterials. 2011.12; 33 (9): 2770-2779. ( DOI )

Masashi Kanayama, Junko Morimoto, Yutaka Matsui, Masahiro Ikesue, Keiko Danzaki, Daisuke Kurotaki, Koyu Ito, Toshimichi Yoshida, Toshimitsu Uede: α9β1 integrin-mediated signaling serves as an intrinsic regulator of pathogenic Th17 cell generation. J. Immunol.. 2011.12; 187 (11): 5851-5864. ( PubMed , DOI )

Mitsuhashi S, Nishino I: Phospholipid synthetic defect and mitophagy in muscle disease. Autophagy. 2011.12; 7 (12): 1559-61. ( PubMed , DOI )

Hiroshi Yukiura, Kotaro Hama, Keita Nakanaga, Masayuki Tanaka, Yoichi Asaoka, Shinichi Okudaira, Naoaki Arima, Asuka Inoue, Takafumi Hashimoto, Hiroyuki Arai, Atsuo Kawahara, Hiroshi Nishina, Junken Aoki: Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish. J. Biol. Chem.. 2011.12; 286 (51): 43972-43983. ( PubMed , DOI )

Goto T., Asashima M.: Chemokine ligand Xenopus CXCLC (XCXCLC) regulates cell movements during early morphogenesis. Dev. Growth Differ.. 2011.12; 53 971-981.. ( PubMed , DOI )

Fujii Shinya, Masuno Hiroyuki, Taoda Yoshiyuki, Kano Atsushi, Wongmayura Angsuma, Nakabayashi Makoto, Ito Nobutoshi, Shimizu Masato, Kawachi Emiko, Hirano Tomoya, Endo Yasuyuki, Tanatani Aya, Kagechika Hiroyuki: Boron cluster-based development of potent nonsecosteroidal vitamin D receptor ligands: direct observation of hydrophobic interaction between protein surface and carborane. J Am Chem Soc. 2011.12; 133 (51): 20933-20941. ( PubMed , DOI )

Yamasaki T, Kawasaki H, Arakawa S, Shimizu K, Shimizu S, Reiner O, Okano H, Nishina S, Azuma N, Penninger JM, Katada T, Nishina H: Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex. J Neurosci. 2011.11; 31 (46): 16872-16883. ( PubMed , DOI )

Katsumori Segawa, Jun Suzuki, Shigekazu Nagata: Constitutive exposure of phosphatidylserine on viable cells. Proc Natl Acad Sci U S A. 2011.11; 108 (48): 19246-19251. ( PubMed , DOI )

Nobuhisa Ikuo, Kishikawa Yuko, Anai Maha, Taga Tetsuya: 造血・免疫系形成　SoxFファミリータンパク質にはAGM領域における造血前駆細胞の未分化性を保持する役割がある(SoxF family proteins have roles in maintenance of immature phenotype of hematopoietic progenitors in the aorta-gonad-mesonephros region) 日本免疫学会総会・学術集会記録. 2011.11; 40 145. ( ichushi )

Tamura T, Sone M, Iwatsubo T, Tagawa K, Wanker EE, Okazawa H: Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease. PLoS ONE. 2011.11; 6 (11): e27408. ( PubMed , DOI )

Mitsuhashi S, Hatakeyama H, Karahashi M, Koumura T, Nonaka I, Hayashi YK, Noguchi S, Sher RB, Nakagawa Y, Manfredi G, Goto Y, Cox GA, Nishino I: Muscle choline kinase beta defect causes mitochondrial dysfunction and increased mitophagy. Human molecular genetics. 2011.10; 20 (19): 3841-51. ( PubMed , DOI )

Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages. PloS one. 2011.10; 6 (10): ( PubMed , DOI )

Takuro Hisanaga, Shuji Terai, Takuya Iwamoto, Taro Takami, Naoki Yamamoto, Tomoaki Murata, Toshifumi Matsuyama, Hiroshi Nishina, Isao Sakaida: TNFR1-mediated signaling is important to induce the improvement of liver fibrosis by bone marrow cell infusion. Cell Tissue Res.. 2011.10; 346 (1): 79-88. ( PubMed , DOI )

Yasuo Horie, Shunsuke Takasuga, Takehiko Sasaki, Hirohide Ohnishi: Functional Analysis of Phosphatidylinositol 3,5-Bisphosphate in Enterocytes Using Pipk III Deficient Mice DIGESTIVE DISEASES AND SCIENCES. 2011.10; 56 (10): 2769-2770.

椨 康一, 田賀 哲也: 合成ポリマーを用いたグリオーマ幹細胞制御(Control of glioma stem cells by the synthetic polymers) 日本癌学会総会記事. 2011.09; 70回 335. ( ichushi )

鹿川 哲史, 備前 典久, 柏木 太一, 信久 幾夫, 清水 健史, 田賀 哲也: New insight of functional interactions between neurons and astrocytes　中枢神経系グリア細胞の発生分化研究の現状と展望(New insight of functional interactions between neurons and astrocytes　Specification of glial cell types in the developing central nervous system) 神経化学. 2011.09; 50 (2-3): 150. ( ichushi )

Yamasaki Shoutarou, Nobuhisa Ikuo, Ramadan Ahmed, Taga Tetsuya: CD45/c-Kit発現を考慮した造血活動をもつ卵黄細胞集団の同定(Identification of a yolk sac cell population with hematopoietic activity in view of CD45/c-Kit expression) Development, Growth & Differentiation. 2011.09; 53 (7): 870-877. ( ichushi )

Hirosato Mashima, Taku Sato, Yasuo Horie, Yuko Nakagawa, Itaru Kojima, Toshiaki Ohteki, Hirohide Ohnishi: Interferon regulatory factor-2 regulates exocytosis mechanisms mediated by SNAREs in pancreatic acinar cells. Gastroenterology. 2011.09; 141 (3): 1102-1113.e1. ( PubMed , DOI )

Yamasaki Shoutarou, Nobuhisa Ikuo, Ramadan Ahmed, Taga Tetsuya: Identification of a yolk sac cell population with hematopoietic activity in view of CD45/c-Kit expression. Dev Growth Differ. 2011.09; 53 (7): 870-877. ( PubMed , DOI )

Yijun Bao, Kentaro Nakagawa, Zeyu Yang, Mitsunobu Ikeda, Kanchanamala Withanage, Mari Ishigami-Yuasa, Yukiko Okuno, Shoji Hata, Hiroshi Nishina, Yutaka Hata: A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription. J. Biochem.. 2011.08; 150 (2): 199-208. ( PubMed , DOI )

Takeya Kasukawa, Koh-hei Masumoto, Itoshi Nikaido, Mamoru Nagano, Kenichiro D. Uno, Kaori Tsujino, Carina Hanashima, Yasufumi Shigeyoshi, Hiroki R. Ueda: Quantitative Expression Profile of Distinct Functional Regions in the Adult Mouse Brain PLOS ONE. 2011.08; 6 (8): e23228. ( PubMed , DOI )

Masato Sasaki, Kohichi Kawahara, Miki Nishio, Koshi Mimori, Ryunosuke Kogo, Koichi Hamada, Bunsho Itoh, Jia Wang, Yukako Komatsu, Yong Ryoul Yang, Hiroki Hikasa, Yasuo Horie, Takayuki Yamashita, Takehiko Kamijo, Yanping Zhang, Yan Zhu, Carol Prives, Toru Nakano, Tak Wah Mak, Takehiko Sasaki, Tomohiko Maehama, Masaki Mori, Akira Suzuki: Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat. Med.. 2011.07; 17 (8): 944-951. ( PubMed , DOI )

Saito Y, Komaki H, Hattori A, Takeuchi F, Sasaki M, Kawabata K, Mitsuhashi S, Tominaga K, Hayashi YK, Nowak KJ, Laing NG, Nonaka I, Nishino I: Extramuscular manifestations in children with severe congenital myopathy due to ACTA1 gene mutations. Neuromuscular disorders : NMD. 2011.07; 21 (7): 489-93. ( PubMed , DOI )

Mitsuhashi S, Ohkuma A, Talim B, Karahashi M, Koumura T, Aoyama C, Kurihara M, Quinlivan R, Sewry C, Mitsuhashi H, Goto K, Koksal B, Kale G, Ikeda K, Taguchi R, Noguchi S, Hayashi YK, Nonaka I, Sher RB, Sugimoto H, Nakagawa Y, Cox GA, Topaloglu H, Nishino I: A congenital muscular dystrophy with mitochondrial structural abnormalities caused by defective de novo phosphatidylcholine biosynthesis. American journal of human genetics. 2011.06; 88 (6): 845-851. ( PubMed , DOI )

樗木俊聡: 腸管粘膜における樹状細胞の役割(The Role of dendritic cells in the intestinal mucosa) 日本耳鼻咽喉科学会会報　114. 2011.06; 107-113.

Oka T, Tagawa K, Ito H, Okazawa H: Dynamic changes of the phosphoproteome in postmortem mouse brains. PLoS ONE. 2011.06; 6 (6): e21405. ( PubMed , DOI )

Satoshi Uchida, Keiji Itaka, Qixian Chen, Kensuke Osada, Kanjiro Miyata, Takehiko Ishii, Mariko Harada-Shiba, Kazunori Kataoka: Combination of chondroitin sulfate and polyplex micelles from Poly (ethylene glycol)-poly {N’-[N-(2-aminoethyl)-2-aminoethyl] aspartamide} block copolymer for prolonged in vivo gene transfection with reduced toxicity Journal of Controlled Release. 2011.05; 155 (2): 296-302. ( DOI )

Yasuo Horie, Shunsuke Takasuga, Takehiko Sasaki, Hirohide Ohnishi: Analysis of Intestinal Inflammation and Fibrosis Based on Impaired Production of Phosphatidylinositol 3,5-Bisphosphate on Enterocytes Using Type III Phosphatidylinositol Phosphate Kinase Deficient Mice GASTROENTEROLOGY. 2011.05; 140 (5): S85.

Nomura W, Ohashi N, Okuda Y, Narumi T, Ikura T, Ito N, Tamamura H: Fluorescence-quenching screening of protein kinase C ligands with an environmentally sensitive fluorophore. Bioconjug Chem. 2011.05; 22 (5): 923-930. ( PubMed , DOI )

Yutaka Matsui, Masahiro Ikesue, Keiko Danzaki, Junko Morimoto, Mami Sato, Shinya Tanaka, Tetsuhito Kojima, Hiroyuki Tsutsui, Toshimitsu Uede: Syndecan-4 prevents cardiac rupture and dysfunction after myocardial infarction. Circulation Research. 2011.05; 108 (11): 1328-1339. ( PubMed , DOI )

Masahiro Ikesue, Yutaka Matsui, Daichi Ohta, Keiko Danzaki, Koyu Ito, Masashi Kanayama, Daisuke Kurotaki, Junko Morimoto, Tetsuhito Kojima, Hiroyuki Tsutsui, Toshimitsu Uede: Syndecan-4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenitor cell mobilization. Arteriosclerosis, Thrombosis, and Vascular Biology. 2011.05; 31 (5): 1066-1074. ( PubMed , DOI )

Naoki Kobayashi, Kohjiro Ueki, Yukiko Okazaki, Aya Iwane, Naoto Kubota, Mitsuru Ohsugi, Motoharu Awazawa, Masatoshi Kobayashi, Takayoshi Sasako, Kazuma Kaneko, Miho Suzuki, Yoshitaka Nishikawa, Kazuo Hara, Kotaro Yoshimura, Isao Koshima, Susumu Goyama, Koji Murakami, Junko Sasaki, Ryozo Nagai, Mineo Kurokawa, Takehiko Sasaki, Takashi Kadowaki: Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance. Proc. Natl. Acad. Sci. U.S.A.. 2011.04; 108 (14): 5753-5758. ( PubMed , DOI )

Kazuki Takeda, Takuro Hayashi, Tetsuya Abe, Yu Hirano, Yuya Hanazono, Masafumi Yohda, Kunio Miki: Dimer structure and conformational variability in the N-terminal region of an archaeal small heat shock protein, StHsp14.0. J Struct Biol. 2011.04; 174 (1): 92-99. ( PubMed , DOI )

Norio Miyamura, Takashi Nakamura, Naoko Goto-Inoue, Nobuhiro Zaima, Takahiro Hayasaka, Tokiwa Yamasaki, Shuji Terai, Isao Sakaida, Mitsutoshi Setou, Hiroshi Nishina: Imaging mass spectrometry reveals characteristic changes in triglyceride and phospholipid species in regenerating mouse liver. Biochem. Biophys. Res. Commun.. 2011.04; 408 (1): 120-125. ( PubMed , DOI )

Shinya Takahashi, Kyoko Sakurai, Arisa Ebihara, Hiroaki Kajiho, Kota Saito, Kenji Kontani, Hiroshi Nishina, Toshiaki Katada: RhoA activation participates in rearrangement of processing bodies and release of nucleated AU-rich mRNAs. Nucleic Acids Res.. 2011.04; 39 (8): 3446-3457. ( PubMed , DOI )

S Takahashi, A Ebihara, H Kajiho, K Kontani, H Nishina, T Katada: RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7. Cell Death Differ.. 2011.04; 18 (4): 645-655. ( PubMed , DOI )

Shinya Kuwashiro, Shuji Terai, Toshiyuki Oishi, Koichi Fujisawa, Toshihiko Matsumoto, Hiroshi Nishina, Isao Sakaida: Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation. Cell Tissue Res.. 2011.04; 344 (1): 125-134. ( PubMed , DOI )

Daisuke Kurotaki, Shigeyuki Kon, Kyeonghwa Bae, Koyu Ito, Yutaka Matsui, Yosuke Nakayama, Masashi Kanayama, Chiemi Kimura, Yoshinori Narita, Takashi Nishimura, Kazuya Iwabuchi, Matthias Mack, Nico van Rooijen, Shimon Sakaguchi, Toshimitsu Uede, Junko Morimoto: CSF-1-dependent red pulp macrophages regulate CD4 T cell responses. J. Immunol.. 2011.02; 186 (4): 2229-2237. ( PubMed , DOI )

Taga Tetsuya, Yamaguchi Yuhei, Kokubu Yasuhiro, Hattori Satoko, Takao Keizo, Inazawa Johji, Miyakawa Tsuyoshi, Kagawa Tetsushi: 薬剤開発のための新しいトランスジェニックマウスモデル　神経発達障害の新しいマウスモデルの確立(New transgenic mouse models for drug development　Establishment of a new mouse model of neurodevelopmental disorder) Journal of Pharmacological Sciences. 2011.02; 115 (Suppl.1): 35P. ( ichushi )

Hiroyuki Tezuka, Yukiko Abe, Jumpei Asano, Taku Sato, Jiajia Liu, Makoto Iwata, Toshiaki Ohteki: Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction. Immunity. 2011.02; 34 (2): 247-257. ( PubMed , DOI )

Yoichiro Fujioka, Masumi Tsuda, Tomoe Hattori, Junko Sasaki, Takehiko Sasaki, Tadaaki Miyazaki, Yusuke Ohba: The Ras-PI3K signaling pathway is involved in clathrin-independent endocytosis and the internalization of influenza viruses. PLoS ONE. 2011.01; 6 (1): e16324. ( PubMed , DOI )

Nobukatsu Kinoshita, Yasuo Horie, Shigetoshi Ohshima, Yohei Hirai, Takahiro Dohmen, Mario Jin, Tamotsu Matsuhashi, Junko Sasaki, Takehiko Sasaki, Masahiro Iizuka, Hirohide Ohnishi: Epimorphin protects hepatocytes from oxidative stress by inhibiting mitochondrial injury. J. Gastroenterol. Hepatol.. 2011.01; 26 (1): 201-206. ( PubMed , DOI )

Hiroshi Hanafusa, Kouki Ishikawa, Shin Kedashiro, Tsukasa Saigo, Shun-Ichiro Iemura, Tohru Natsume, Masayuki Komada, Hiroshi Shibuya, Atsuki Nara, Kunihiro Matsumoto: Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor. Nat Commun. 2011.01; 2 158. ( PubMed , DOI )

Taga Tetsuya, Yamaguchi Yuhei, Kokubu Yasuhiro, Hattori Satoko, Takao Keizo, Inazawa Johji, Miyakawa Tsuyoshi, Kagawa Tetsushi: Establishment of a new mouse model of neurodevelopmental disorder JOURNAL OF PHARMACOLOGICAL SCIENCES. 2011; 115 35P.

Yoshimi Uchida, Tadanori Shimomura, Jun Hirayama & Hiroshi Nishina: Light, Reactive Oxygen Species, and Magnetic Fields Activating ERK/MAPK Signaling Pathway in Cultured Zebrafish Cells Applyed Magnetic Resonance . 2011; 42 69-77.

Tomomi Osaki, Yoshimi Uchida, Jun Hirayama, Hiroshi Nishina: Diphenyleneiodonium chloride, an inhibitor of reduced nicotinamide adenine dinucleotide phosphate oxidase, suppresses light-dependent induction of clock and DNA repair genes in zebrafish. Biol. Pharm. Bull.. 2011; 34 (8): 1343-1347. ( PubMed )

Prakash T, Oshima K, Morita H, Fukuda S, Imaoka A, Kumar N., Sharma VK, Takahashi M, Saitou N, Taylor TD, Ohno H, Umesaki Y, Hattori M: Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent inducer of Th17 cell differentiation Cell Host & Microbe. 2011;

信久 幾夫, 岸川 陽子, 上村 麻実, Anani Maha, Gomaa Ahmed, 金井 正美, 金井 克晃, 田賀 哲也: 大動脈-生殖隆起-中腎領域由来の造血前駆細胞におけるSox-17の働きが未熟表現型を維持する(Role of Sox-17 in hamatopoietic progenitors from the aorta-gonad-mesonephros region maintains immature phenotype) 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2010.12; 83回・33回 3P-0895. ( ichushi )

田賀 哲也: 発生と分化におけるエピジェネティック制御　細胞外の合図と細胞固有のプログラムの相互作用が脳発生を制御する(Epigenetic Regulation in Development and Differentiation　Cross-interactions among cell-external cues and cell-intrinsic programs controlling brain development) 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2010.12; 83回・33回 1S12-1. ( ichushi )

備前 典久, 井上 俊洋, 清水 健史, 鹿川 哲史, 田賀 哲也: 神経幹/前駆細胞における細胞周期調節因子cyclin D1は細胞周期非依存的にアストロサイト分化を阻害する(Cyclin D1 inhibits astrocyte differentiation from neural stem/progenitor cells in a manner independent of cell cycle progression) 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2010.12; 83回・33回 3P-0876. ( ichushi )

Yoshitake Kanazawa, Yasuyuki Saito, Yana Supriatna, Hiroyuki Tezuka, Takenori Kotani, Yoji Murata, Hideki Okazawa, Hiroshi Ohnishi, Yoshitaka Kinouchi, Yoshihisa Nojima, Toshiaki Ohteki, Tooru Shimosegawa, Takashi Matozaki: Role of SIRPα in regulation of mucosal immunity in the intestine. Genes Cells. 2010.12; 15 (12): 1189-1200. ( PubMed , DOI )

Bizen Norihisa, Shimizu Takeshi, Inoue Toshihiro, Kagawa Tetsushi, Taga Tetsuya: Cross-talk between growth and differentiation pathways in cell fate determination in the developing brain DIFFERENTIATION. 2010.11; 80 S8. ( DOI )

Jinzhan Wu, Junko Kubota, Jun Hirayama, Yoko Nagai, Sachiko Nishina, Tadashi Yokoi, Yoichi Asaoka, Jungwon Seo, Nao Shimizu, Hiroaki Kajiho, Takashi Watanabe, Noriyuki Azuma, Toshiaki Katada, Hiroshi Nishina: p38 Mitogen-activated protein kinase controls a switch between cardiomyocyte and neuronal commitment of murine embryonic stem cells by activating myocyte enhancer factor 2C-dependent bone morphogenetic protein 2 transcription. Stem Cells Dev.. 2010.11; 19 (11): 1723-1734. ( PubMed , DOI )

Revolving movement of a dynamic cluster of actin filaments during mitosis 2010.11; 191 (3): 453-462. ( PubMed , DOI )

Toshiyasu Goto, Akimasa Fukui, Hiroshi Shibuya, Ray Keller, Makoto Asashima: Xenopus furry contributes to release of microRNA gene silencing. Proc. Natl. Acad. Sci. U.S.A.. 2010.11; 107 (45): 19344-19349. ( PubMed , DOI )

Hiroyuki Tezuka, Toshiaki Ohteki: A gas governing mucosal immunity. Vaccine. 2010.11; 28 (50): 8039-8040. ( PubMed , DOI )

Aoki Y, Nakamura A, Yokota T, Saito T, Okazawa H, Nagata T, Takeda SI: In-frame dystrophin following exon 51-skipping improves muscle pathology and function in the exon 52-deficient mdx mouse. Mol Ther. 2010.11; 18 (11): 1995-2005. ( PubMed , DOI )

Ryosuke Nakamura, Y Uchida, M Higuchi, R Nakamura, I Tsuge, A Urisu, R Teshima: A convenient and sensitive allergy test: IgE crosslinking-induced luciferase expression in cultured mast cells. Allergy. 2010.10; 65 (10): 1266-1273. ( PubMed , DOI )

Ishigaki K, Mitsuhashi S, Kuwatsuru R, Murakami T, Shishikura K, Suzuki H, Hirayama Y, Nonaka I, Osawa M: High-density areas on muscle CT in childhood-onset Pompe disease are caused by excess calcium accumulation. Acta neuropathologica. 2010.10; 120 (4): 537-43. ( PubMed , DOI )

Yoichi Asaoka, Hiroshi Nishina: Diverse physiological functions of MKK4 and MKK7 during early embryogenesis. J. Biochem.. 2010.10; 148 (4): 393-401. ( PubMed , DOI )

Ogawa Y., Nonaka Y., Goto T., Ohnishi E., Hiramatsu T., Kii I., Yoshida M., Ikura T., Onogi H., Shibuya H., Hosoya T., Ito N., Hagiwara M.: Development of a novel selective inhibitor of the Downsyndrome-related kinase Dyrk1A. Nat. Commun.. 2010.10; ( PubMed , DOI )

Tamura T, Horiuchi D, Chen YC, Sone M, Miyashita T, Saitoe M, Yoshimura N, Chiang AS, Okazawa H: Drosophila PQBP1 regulates learning acquisition at projection neurons in aversive olfactory conditioning. J. Neurosci. 2010.10; 30 (42): 14091-14101. ( PubMed , DOI )

Konno M, Hamazaki TS, Fukuda S, Tokuhara M, Uchiyama H, Okazawa H, Okochi H, Asashima M: Efficiently differentiating vascular endothelial cells from adipose tissue-derived mesenchymal stem cells in serum-free culture. Biochem Biophys Res Commun. 2010.10; 400 (4): 461-465. ( PubMed , DOI )

Yoshinaga Yutaka, Kagawa Tetsushi, Shimizu Takeshi, Inoue Toshihiro, Takada Shinji, Kuratsu Jun-ichi, Taga Tetsuya: Wnt3a promotes hippocampal neurogenesis by shortening cell cycle duration of neural progenitor cells. Cell Mol Neurobiol. 2010.10; 30 (7): 1049-1058. ( PubMed , DOI )

Honda S, Hayashi S, Imoto I, Toyama J, Okazawa H, Nakagawa E, Goto Y, Inazawa J: Copy-number variations on the X chromosome in Japanese patients with mental retardation detected by array-based comparative genomic hybridization analysis. J Hum Genet. 2010.09; 55 (9): 590-599. ( PubMed , DOI )

Laura A Volpicelli-Daley, Louise Lucast, Liang-Wei Gong, Lijuan Liu, Junko Sasaki, Takehiko Sasaki, Charles S Abrams, Yasunori Kanaho, Pietro De Camilli: Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain. J. Biol. Chem.. 2010.09; 285 (37): 28708-28714. ( PubMed , DOI )

Ryuichi Mashima, Kazuho Honda, Yi Yang, Yohei Morita, Akane Inoue, Sumimasa Arimura, Hiroshi Nishina, Hideo Ema, Hiromitsu Nakauchi, Brian Seed, Hideaki Oda, Yuji Yamanashi: Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma. Lab. Invest.. 2010.09; 90 (9): 1357-1364. ( PubMed , DOI )

Ramadan Ahmed, Nobuhisa Ikuo, Yamasaki Shoutarou, Nakagata Naomi, Taga Tetsuya: Cells with hematopoietic activity in the mouse placenta reside in side population. Genes Cells. 2010.09; 15 (9): 983-994. ( PubMed , DOI )

Shinya Urano, Chinatsu Kaneko, Takahito Nei, Natsuki Motoi, Ryushi Tazawa, Masato Watanabe, Masahiro Tomita, Takahiro Adachi, Hiroko Kanazawa, Koh Nakata: A cell-free assay to estimate the neutralizing capacity of granulocyte-macrophage colony-stimulating factor autoantibodies. J. Immunol. Methods. 2010.08; 360 (1-2): 141-148. ( PubMed , DOI )

鹿川 哲史, 清水 健史, 荒木 喜美, 竹田 直樹, 中潟 直巳, 信久 幾夫, 田賀 哲也: 中枢神経系グリア亜集団細胞系譜のGFAP/Creレポーターマウスを用いた解析(Analysis of glial cell sub-lineages in the developing central nervous system using GFAP/Cre-reporter mouse system) 神経化学. 2010.08; 49 (2-3): 617. ( ichushi )

備前 典久, 井上 俊洋, 清水 健史, 鹿川 哲史, 田賀 哲也: 神経幹細胞/前駆細胞における細胞周期調節因子cyclin D1のアストロサイト分化抑制機構(Molecular mechanism underlying cyclin D1 mediated inhibition of astrocyte differentiation from neural stem/progenitor cells) 神経化学. 2010.08; 49 (2-3): 536. ( ichushi )

Takeshi Maruyama, Hisae Kadowaki, Noriaki Okamoto, Atsushi Nagai, Isao Naguro, Atsushi Matsuzawa, Hiroshi Shibuya, Keiji Tanaka, Shigeo Murata, Kohsuke Takeda, Hideki Nishitoh, Hidenori Ichijo: CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response. EMBO J.. 2010.08; 29 (15): 2501-2514. ( PubMed , DOI )

椨 康一, 田賀 哲也: C6グリオーマ細胞株においてMPはSPの維持に寄与する(Main population helps side population in C6 glioma cell line) 日本癌学会総会記事. 2010.08; 69回 232. ( ichushi )

Shiwaku H, Yoshimura N, Tamura T, Sone M, Ogishima S, Watase K, Tagawa K, Okazawa H: Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity. EMBO J. 2010.07; 29 (14): 2446-2460. ( PubMed , DOI )

Takahashi M, Mizuguchi M, Shinoda H, Aizawa T, Demura M, Okazawa H, Kawano K: Polyglutamine tract-binding protein-1 binds to U5-15kD via a continuous 23-residue segment of the C-terminal domain. Biochim Biophys Acta. 2010.07; 1804 (7): 1500-1507. ( PubMed , DOI )

Jungwon Seo, Yoichi Asaoka, Yoko Nagai, Jun Hirayama, Tokiwa Yamasaki, Misako Namae, Shinya Ohata, Nao Shimizu, Takahiro Negishi, Daiju Kitagawa, Hisato Kondoh, Makoto Furutani-Seiki, Josef M Penninger, Toshiaki Katada, Hiroshi Nishina: Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation. J. Cell. Biochem.. 2010.07; 110 (4): 1022-1037. ( PubMed , DOI )

Toshihiko Matsumoto, Shuji Terai, Toshiyuki Oishi, Shinya Kuwashiro, Koichi Fujisawa, Naoki Yamamoto, Yusuke Fujita, Yoshihiko Hamamoto, Makoto Furutani-Seiki, Hiroshi Nishina, Isao Sakaida: Medaka as a model for human nonalcoholic steatohepatitis. Dis Model Mech. 2010.07; 3 (7-8): 431-440. ( PubMed , DOI )

Masahiko Tanaka, Hideyuki Hara, Hiroshi Nishina, Kentaro Hanada, Ken'ichi Hagiwara, Tomohiko Maehama: An improved method for cell-to-cell transmission of infectious prion. Biochem. Biophys. Res. Commun.. 2010.07; 397 (3): 505-508. ( PubMed , DOI )

Yoshimi Tokuzawa, Ken Yagi, Yzumi Yamashita, Yutaka Nakachi, Itoshi Nikaido, Hidemasa Bono, Yuichi Ninomiya, Yukiko Kanesaki-Yatsuka, Masumi Akita, Hiromi Motegi, Shigeharu Wakana, Tetsuo Noda, Fred Sablitzky, Shigeki Arai, Riki Kurokawa, Toru Fukuda, Takenobu Katagiri, Christian Schoenbach, Tatsuo Suda, Yosuke Mizuno, Yasushi Okazaki: Id4, a New Candidate Gene for Senile Osteoporosis, Acts as a Molecular Switch Promoting Osteoblast Differentiation PLOS GENETICS. 2010.07; 6 (7): e1001019. ( PubMed , DOI )

Inaba Yuka, Nakabayashi Makoto, Itoh Toshimasa, Yoshimoto Nobuko, Ikura Teikichi, Ito Nobutoshi, Shimizu Masato, Yamamoto Keiko: 22S-butyl-1alpha,24R-dihydroxyvitamin D3: recovery of vitamin D receptor agonistic activity. J Steroid Biochem Mol Biol. 2010.07; 121 (1-2): 146-150. ( PubMed , DOI )

Inoue Toshihiro, Kagawa Tetsushi, Inoue-Mochita Miyuki, Isono Kyoichi, Ohtsu Naoki, Nobuhisa Ikuo, Fukushima Mikiko, Tanihara Hidenobu, Taga Tetsuya: Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. FEBS Lett. 2010.07; 584 (14): 3233-3238. ( PubMed , DOI )

Yoko Nagai, Yoichi Asaoka, Misako Namae, Kota Saito, Haruka Momose, Hiroshi Mitani, Makoto Furutani-Seiki, Toshiaki Katada, Hiroshi Nishina: The LIM protein Ajuba is required for ciliogenesis and left-right axis determination in medaka. Biochem. Biophys. Res. Commun.. 2010.06; 396 (4): 887-893. ( PubMed , DOI )

Yong-Mei Guo, Keiko Ishii, Makoto Hirokawa, Hiroyuki Tagawa, Hideaki Ohyagi, Yoshihiro Michishita, Kumi Ubukawa, Junsuke Yamashita, Toshiaki Ohteki, Nobuyuki Onai, Kazuyoshi Kawakami, Weiguo Xiao, Kenichi Sawada: CpG-ODN 2006 and human parvovirus B19 genome consensus sequences selectively inhibit growth and development of erythroid progenitor cells. Blood. 2010.06; 115 (22): 4569-4579. ( PubMed , DOI )

Junko Sasaki, Satoshi Kofuji, Reietsu Itoh, Toshihiko Momiyama, Kiyohiko Takayama, Haruka Murakami, Shinsuke Chida, Yuko Tsuya, Shunsuke Takasuga, Satoshi Eguchi, Ken Asanuma, Yasuo Horie, Kouichi Miura, Elizabeth Michele Davies, Christina Mitchell, Masakazu Yamazaki, Hirokazu Hirai, Tadaomi Takenawa, Akira Suzuki, Takehiko Sasaki: The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature. 2010.05; 465 (7297): 497-501. ( PubMed , DOI )

Enokido Y, Tamura T, Ito H, Arumughan A, Komuro A, Shiwaku H, Sone M, Foulle R, Sawada H, Ishiguro H, Ono T, Murata M, Kanazawa I, Tomilin N, Tagawa K, Wanker EE, Okazawa H: Mutant huntingtin impairs Ku70-mediated DNA repair. J Cell Biol. 2010.05; 189 (3): 425-443. ( PubMed , DOI )

Uchida Yoshimi, Hirayama Jun, Nishina Hiroshi: 共通起源　体内時計の調節とDNA損傷反応における信号伝達の類似性(A Common Origin: Signaling Similarities in the Regulation of the Circadian Clock and DNA Damage Responses) Biological & Pharmaceutical Bulletin. 2010.04; 33 (4): 535-544. ( ichushi )

Shimizu S, Konishi A, Nishida Y, Mizuta T, Nishina H, Yamamoto A, Tsujimoto Y: Involvement of JNK in the regulation of autophagic cell death. Oncogene. 2010.04; 29 (14): 2070-2082. ( PubMed , DOI )

Kentaro Nakagawa, Misato Sugahara, Tokiwa Yamasaki, Hiroaki Kajiho, Shinya Takahashi, Jun Hirayama, Yasuhiro Minami, Yasutaka Ohta, Toshio Watanabe, Yutaka Hata, Toshiaki Katada, Hiroshi Nishina: Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation. Biochem. J.. 2010.04; 427 (2): 237-245. ( PubMed , DOI )

Akira Nifuji, Hisashi Ideno, Yoshio Ohyama, Rieko Takanabe, Ryoko Araki, Masumi Abe, Masaki Noda, Hiroshi Shibuya: Nemo-like kinase (NLK) expression in osteoblastic cells and suppression of osteoblastic differentiation. Exp. Cell Res.. 2010.04; 316 (7): 1127-1136. ( PubMed , DOI )

Ishiura N, Nakashima H, Watanabe R, Kuwano Y, Adachi T, Takahashi Y, Tsubata T, Okochi H, Tamaki K, Tedder TF, Fujimoto M: Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation. Eur J Immunol. 2010.04; 40 (4): 1192-1204. ( PubMed , DOI )

Takahiro Negishi, Yoko Nagai, Yoichi Asaoka, Mami Ohno, Misako Namae, Hiroshi Mitani, Takashi Sasaki, Nobuyoshi Shimizu, Shuji Terai, Isao Sakaida, Hisato Kondoh, Toshiaki Katada, Makoto Furutani-Seiki, Hiroshi Nishina: Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression in medaka. Hepatology. 2010.03; 51 (3): 1037-1045. ( PubMed , DOI )

Hiroyuki Tezuka, Toshiaki Ohteki: Regulation of intestinal homeostasis by dendritic cells. Immunol Rev. 2010.03; 234 (1): 247-258. ( PubMed , DOI )

Honglu Zhang, Ju He, Tatiana G. Kutateladze, Takahiro Sakai, Takehiko Sasaki, Nicolas Markadieu, Christophe Erneux, Glenn D. Prestwich: 5-Stabilized Phosphatidylinositol 3,4,5-Trisphosphate Analogues Bind Grp1 PH, Inhibit Phosphoinositide Phosphatases, and Block Neutrophil Migration CHEMBIOCHEM. 2010.02; 11 (3): 388-395. ( PubMed , DOI )

Goto T., Ohnishi E., Sato A.(The first three authors contributed equally), Kim M., Iemura S., Ishitani T., Natsume T., Ohnishi J.and Shibuya H.: Nemo-like kinase, an essential effector of anterior formation, functions downstream of p38 MAP kinase. Mol. Cell. Biol.. 2010.02; 30 675-683. ( PubMed , DOI )

Eriko Ohnishi, Toshiyasu Goto, Atsushi Sato, Mi-Sun Kim, Shun-Ichiro Iemura, Tohru Ishitani, Tohru Natsume, Junji Ohnishi, Hiroshi Shibuya: Nemo-like kinase, an essential effector of anterior formation, functions downstream of p38 mitogen-activated protein kinase. Mol. Cell. Biol.. 2010.02; 30 (3): 675-683. ( PubMed , DOI )

Keiichiro Suzuki, Fumi Ohbayashi, Itoshi Nikaido, Akihiko Okuda, Haruyoshi Takaki, Yasushi Okazaki, Kohnosuke Mitani: Integration of exogenous DNA into mouse embryonic stem cell chromosomes shows preference into genes and frequent modification at junctions CHROMOSOME RESEARCH. 2010.02; 18 (2): 191-201. ( PubMed , DOI )

Yukihide Watanabe, Susumu Itoh, Toshiyasu Goto, Eriko Ohnishi, Masako Inamitsu, Fumiko Itoh, Kiyotoshi Satoh, Eliza Wiercinska, Weiwen Yang, Liang Shi, Aya Tanaka, Naoko Nakano, A Mieke Mommaas, Hiroshi Shibuya, Peter Ten Dijke, Mitsuyasu Kato: TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling. Mol. Cell. 2010.01; 37 (1): 123-134. ( PubMed , DOI )

Jumpei Asano, Hiroyuki Tada, Nobuyuki Onai, Taku Sato, Yasuo Horie, Yukari Fujimoto, Koichi Fukase, Akira Suzuki, Tak W Mak, Toshiaki Ohteki: Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo. J Immunol. 2010.01; 184 (2): 736-745. ( PubMed , DOI )

Kagawa Tetsushi, Shimizu Takeshi, Araki Kimi, Takeda Naoki, Nakagata Naomi, Nobuhisa Ikuo, Taga Tetsuya: Analysis of glial cell sub-lineages in the developing central nervous system using GFAP/Cre-reporter mouse system NEUROSCIENCE RESEARCH. 2010; 68 E240. ( DOI )

Bizen Norihisa, Inoue Toshihiro, Shimizu Takeshi, Kagawa Tetsushi, Taga Tetsuya: Molecular mechanism underlying cyclin D1 mediated inhibition of astrocyte differentiation from neural stem/progenitor cells NEUROSCIENCE RESEARCH. 2010; 68 E132. ( DOI )

Masahide Takeda, Wataru Ito, Masako Tanabe, Shigeharu Ueki, Junko Kihara, Hikari Kato, Tomomi Tanigai, Hiroyuki Kayaba, Takehiko Sasaki, Junichi Chihara: The Pathophysiological Roles of PI3Ks and Therapeutic Potential of Selective Inhibitors in Allergic Inflammation INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2010; 152 90-95. ( PubMed , DOI )

Yoshimi Uchida, Jun Hirayama, Hiroshi Nishina: A common origin: signaling similarities in the regulation of the circadian clock and DNA damage responses. Biol. Pharm. Bull.. 2010; 33 (4): 535-544. ( PubMed )

Takehiko Sasaki, Junko Sasaki, Shunsuke Takasuga, Satoshi Eguchi, Satoshi Kofuji: Physiology of phosphoinositide metabolism JOURNAL OF PHYSIOLOGICAL SCIENCES. 2010; 60 S68.

Neely1 GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmen L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NA, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks A, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM.: A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell. 2010; 141 (1): 142-153. ( DOI )

Tabu Kouichi, Kimura Taichi, Sasai Ken, Wang Lei, Bizen Norihisa, Nishihara Hiroshi, Taga Tetsuya, Tanaka Shinya: Analysis of an alternative human CD133 promoter reveals the implication of Ras/ERK pathway in tumor stem-like hallmarks. Mol Cancer. 2010; 9 39. ( PubMed , DOI )

Ryota Saito, Tokiwa Yamasaki, Yoko Nagai, Jinzhan Wu, Hiroaki Kajiho, Tadashi Yokoi, Eiichiro Noda, Sachiko Nishina, Hitoshi Niwa, Noriyuki Azuma, Toshiaki Katada, Hiroshi Nishina: CrxOS maintains the self-renewal capacity of murine embryonic stem cells. Biochem. Biophys. Res. Commun.. 2009.12; 390 (4): 1129-1135. ( PubMed , DOI )

Ramadan Ahmed, Nobuhisa Ikuo, Yamasaki Shoutarou, Taga Tetsuya: 造血・リンパ器官形成　幹細胞　マウス胚の胎盤において造血活性をもつ細胞の性状解析(Characterization of cells that have hematopoietic activity in the placenta of mouse embryo) 日本免疫学会総会・学術集会記録. 2009.11; 39 49. ( ichushi )

Masahiro Kawahara, Yusuke Shimo, Azusa Hitomi, Yuki Mochida, Takahiro Sogo, Hiroshi Ueda, Teruyuki Nagamune: Fluorescein-responsive migration of mammalian cells equipped with an antibody/receptor chimera. Journal of Bioscience and Bioengineering. 2009.11; 108 S33. ( DOI )

Takehiko Sasaki, Shunsuke Takasuga, Junko Sasaki, Satoshi Kofuji, Satoshi Eguchi, Masakazu Yamazaki, Akira Suzuki: Mammalian phosphoinositide kinases and phosphatases. Prog. Lipid Res.. 2009.11; 48 (6): 307-343. ( PubMed , DOI )

Ito H, Yoshimura N, Kurosawa M, Ishii S, Nukina N, Okazawa H: Knock-down of PQBP1 impairs anxiety-related cognition in mouse. Hum Mol Genet. 2009.11; 18 (22): 4239-4254. ( PubMed , DOI )

Fukushima Mikiko, Setoguchi Takao, Komiya Setsuro, Tanihara Hidenobu, Taga Tetsuya: Retinal astrocyte differentiation mediated by leukemia inhibitory factor in cooperation with bone morphogenetic protein 2. Int J Dev Neurosci. 2009.11; 27 (7): 685-690. ( PubMed , DOI )

Mitsuhashi Satomi, Nonaka Ikuya, Wu Shiwen, Alberto Carlos, Moreno Ibarra, Shalaby Sherine, Hayashi Yukiko K., Noguchi Satoru, Nishino Ichizo: Multi-minicore病における遠位型ミオパシー(Distal Myopathy in Multi-minicore Disease) Internal Medicine. 2009.10; 48 (19): 1759-1762. ( ichushi )

Chin JH, Shiwaku H, Goda O, Komuro A, Okazawa H: Neural stem cells express Oct-3/4. Biochem Biophys Res Commun. 2009.10; 388 (2): 247-251. ( PubMed , DOI )

Takayuki Tomita, Takanori Kanai, Teruji Totsuka, Yasuhiro Nemoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Naoya Sakamoto, Toshiaki Ohteki, Toshifumi Hibi, Mamoru Watanabe: IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis. Eur J Immunol. 2009.10; 39 (10): 2737-2747. ( PubMed , DOI )

Sanosaka Tsukasa, Namihira Masakazu, Kohyama Jun, Semi Katsunori, Deneen Benjamin, Taga Tetsuya, Nakashima Kinichi: 神経前駆細胞にアストロサイト分化能を与えるエピジェネティック機構(Epigenetic mechanism conferring astrocytic potential on neural precursor cells) Neuroscience Research. 2009.09; 65 (Suppl.1): S19. ( ichushi )

Tomoyuki Yoshida, Satoshi Uchida, Masayoshi Mishina: Regulation of synaptic vesicle accumulation and axon terminal remodeling during synapse formation by distinct Ca2+ signaling Journal of Neurochemistry. 2009.09; 111 (1): 160-170. ( DOI )

Hayashi YK, Matsuda C, Ogawa M, Goto K, Tominaga K, Mitsuhashi S, Park YE, Nonaka I, Hino-Fukuyo N, Haginoya K, Sugano H, Nishino I: Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy. The Journal of clinical investigation. 2009.09; 119 (9): 2623-33. ( PubMed , DOI )

Jun Hirayama, Norio Miyamura, Yoshimi Uchida, Yoichi Asaoka, Reiko Honda, Kenji Sawanobori, Takeshi Todo, Takuro Yamamoto, Paolo Sassone-Corsi, Hiroshi Nishina: Common light signaling pathways controlling DNA repair and circadian clock entrainment in zebrafish. Cell Cycle. 2009.09; 8 (17): 2794-2801. ( PubMed )

椨 康一, 田賀 哲也: ラットC6グリオーマ細胞株におけるmain populationによるside populationの維持(Maintenance of side population in C6 glioma by main population) 日本癌学会総会記事. 2009.08; 68回 270. ( ichushi )

Arai A, Mitsuhashi S, Saito Y, Komaki H, Sakuma H, Nakagawa E, Sugai K, Sasaki M, Robertson SP, Nishimura G, Yamamoto T, Nonaka I, Nishino I: Nemaline (actin) myopathy with myofibrillar dysgenesis and abnormal ossification. Neuromuscular disorders : NMD. 2009.07; 19 (7): 485-8. ( PubMed , DOI )

Norio Miyamura, Jun Hirayama, Kenji Sawanobori, Teruya Tamaru, Yoichi Asaoka, Reiko Honda, Takuro Yamamoto, Hatsume Uno, Ken Takamatsu, Hiroshi Nishina: CLOCK:BMAL-independent circadian oscillation of zebrafish Cryptochrome1a gene. Biol. Pharm. Bull.. 2009.07; 32 (7): 1183-1187. ( PubMed )

Takashi Nakamura, Hiroshi Nishina: Liver development: lessons from knockout mice and mutant fish. Hepatol. Res.. 2009.07; 39 (7): 633-644. ( PubMed , DOI )

備前 典久, 井上 俊洋, 清水 健史, 鹿川 哲史, 田賀 哲也: サイクリンD1は神経幹細胞/前駆細胞からの星状細胞分化を細胞周期調節非依存性に抑制する(Cyclin D1 inhibits astrocyte differentiation from neural stem/progenitor cells in a manner independent of cell cycle regulation) 神経化学. 2009.06; 48 (2-3): 205. ( ichushi )

Takahashi M, Mizuguchi M, Shinoda H, Tomoyasu AT, Demura M, Okazawa H, Kawano K: Polyglutamine tract binding protein-1 is an intrinsically unstructured protein Biochim. Biophys. Acta. 2009.06; 1794 (6): 936-943. ( PubMed , DOI )

Yumiko Anezaki, Shigetoshi Ohshima, Hajime Ishii, Nobukatsu Kinoshita, Takahiro Dohmen, Ei Kataoka, Wataru Sato, Masahiro Iizuka, Takashi Goto, Junko Sasaki, Takehiko Sasaki, Akira Suzuki, Hirohide Ohnishi, Yasuo Horie: Sex difference in the liver of hepatocyte-specific Pten-deficient mice: A model of nonalcoholic steatohepatitis. Hepatol. Res.. 2009.06; 39 (6): 609-618. ( PubMed , DOI )

Masashi Kanayama, Daisuke Kurotaki, Junko Morimoto, Tsuyoshi Asano, Yutaka Matsui, Yosuke Nakayama, Yoshinari Saito, Koyu Ito, Chiemi Kimura, Norimasa Iwasaki, Koji Suzuki, Tanenobu Harada, Hong Mei Li, Jun Uehara, Tadaaki Miyazaki, Akio Minami, Shigeyuki Kon, Toshimitsu Uede: Alpha9 integrin and its ligands constitute critical joint microenvironments for development of autoimmune arthritis. J. Immunol.. 2009.06; 182 (12): 8015-8025. ( PubMed , DOI )

Kimura T, Sakai M, Tabu K, Wang L, Tsunematsu R, Tsuda M, Sawa H, Nagashima K, Nishihara H, Hatakeyama S, Nakayama K, Ladanyi M, Tanaka S, Nakayama KI: Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration. Laboratory investigation; a journal of technical methods and pathology. 2009.06; 89 (6): 645-56. ( PubMed , DOI )

Nao Shimizu, Hajime Watanabe, Junko Kubota, Jinzhan Wu, Ryota Saito, Tadashi Yokoi, Takumi Era, Takeshi Iwatsubo, Takashi Watanabe, Sachiko Nishina, Noriyuki Azuma, Toshiaki Katada, Hiroshi Nishina: Pax6-5a promotes neuronal differentiation of murine embryonic stem cells. Biol. Pharm. Bull.. 2009.06; 32 (6): 999-1003. ( PubMed )

Naoki Kobayashi, Kohjiro Ueki, Takehiko Sasaki, Takashi Kadowaki: Crucial Role of Class IB PI3-Kinase, PI3K gamma, in Obesity-Induced Insulin Resistance DIABETES. 2009.06; 58 A352.

Taku Sato, Nobuyuki Onai, Hiroki Yoshihara, Fumio Arai, Toshio Suda, Toshiaki Ohteki: Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. Nat Med. 2009.06; 15 (6): 696-700. ( PubMed , DOI )

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Dual Role of Cdc42 in Spindle Orientation Control of Adherent Cells 2009.05; 29 (10): 2816-2827. ( PubMed , DOI )

Jun Yamada, Junji Hamuro, Atsuki Fukushima, Toshiaki Ohteki, Kazuto Terai, Yoichiro Iwakura, Hideo Yagita, Shigeru Kinoshita: MHC-matched corneal allograft rejection in an IFN-gamma/IL-17-independent manner in C57BL/6 mice. Invest Ophthalmol Vis Sci. 2009.05; 50 (5): 2139-2146. ( PubMed , DOI )

Akihiko Nishikimi, Hideo Fukuhara, Wenjuan Su, Tsunaki Hongu, Shunsuke Takasuga, Hisashi Mihara, Qinhong Cao, Fumiyuki Sanematsu, Motomu Kanai, Hiroshi Hasegawa, Yoshihiko Tanaka, Masakatsu Shibasaki, Yasunori Kanaho, Takehiko Sasaki, Michael A Frohman, Yoshinori Fukui: Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis. Science. 2009.04; 324 (5925): 384-387. ( PubMed , DOI )

Morimoto N, Nagai M, Miyazaki K, Kurata T, Takehisa Y, Ikeda Y, Kamiya T, Okazawa H, Abe K: Progressive decrease in the level of YAPdeltaCs, pro-survival isoforms of YAP, in the spinal cord of transgenic mouse carrying a mutant SOD1 gene J Neurosci Res. 2009.03; 87 (4): 928-936. ( PubMed )

Hajime Ishii, Yasuo Horie, Shigetoshi Ohshima, Yumiko Anezaki, Nobukatsu Kinoshita, Takahiro Dohmen, Ei Kataoka, Wataru Sato, Takashi Goto, Junko Sasaki, Takehiko Sasaki, Sumio Watanabe, Akira Suzuki, Hirohide Ohnishi: Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. J. Hepatol.. 2009.03; 50 (3): 562-571. ( PubMed , DOI )

Chihiro Mogi, Masayuki Tobo, Hideaki Tomura, Naoya Murata, Xiao-Dong He, Koichi Sato, Takao Kimura, Tamotsu Ishizuka, Takehiko Sasaki, Takashi Sato, Yasuyuki Kihara, Satoshi Ishii, Akihiro Harada, Fumikazu Okajima: Involvement of Proton-Sensing TDAG8 in Extracellular Acidification-Induced Inhibition of Proinflammatory Cytokine Production in Peritoneal Macrophages JOURNAL OF IMMUNOLOGY. 2009.03; 182 (5): 3243-3251. ( PubMed , DOI )

Shuhei Tanemura, Haruka Momose, Nao Shimizu, Daiju Kitagawa, Jungwon Seo, Tokiwa Yamasaki, Kentaro Nakagawa, Hiroaki Kajiho, Josef M Penninger, Toshiaki Katada, Hiroshi Nishina: Blockage by SP600125 of Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway. J. Biochem.. 2009.03; 145 (3): 345-354. ( PubMed , DOI )

Sone M, Uchida A, Komatsu A, Suzuki E, Ibuki I, Asada M, Shiwaku H, Tamura T, Hoshino M, Okazawa H, Nabeshima Y: Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening. PLoS ONE. 2009.02; 4 (2): e4466. ( PubMed , DOI )

Shinya Ohata, Makiko Nawa, Takeshi Kasama, Tokiwa Yamasaki, Kenji Sawanobori, Shoji Hata, Takashi Nakamura, Yoichi Asaoka, Toshio Watanabe, Hitoshi Okamoto, Takahiko Hara, Shuji Terai, Isao Sakaida, Toshiaki Katada, Hiroshi Nishina: Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells. Biochem. Biophys. Res. Commun.. 2009.02; 379 (4): 817-823. ( PubMed , DOI )

Inaba Y, Yoshimoto N, Sakamaki Y, Nakabayashi M, Ikura T, Tamamura H, Ito N, Shimizu M, Yamamoto K: A New Class of Vitamin D Analogues that Induce Structural Rearrangement of the Ligand-Binding Pocket of the Receptor. J Med Chem. 2009.02; ( PubMed , DOI )

Namihira Masakazu, Kohyama Jun, Semi Katsunori, Sanosaka Tsukasa, Deneen Benjamin, Taga Tetsuya, Nakashima Kinichi: Committed neuronal precursors confer astrocytic potential on residual neural precursor cells. Dev Cell. 2009.02; 16 (2): 245-255. ( PubMed , DOI )

Toda M, Hisano R, Yurugi H, Akita K, Maruyama K, Inoue M, Adachi T, Tsubata T, Nakada H: Ligation of tumour-produced mucins to CD22 dramatically impairs splenic marginal zone B-cells. Biochem J. 2009.02; 417 (3): 673-683. ( PubMed , DOI )

Hou R, Ohtsuji M, Ohtsuji N, Zhang L, Adachi T, Hirose S, Tsubata T: Centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD.CD72b congenic mice. Biochem Biophys Res Commun. 2009.02; 380 (1): 193-197. ( PubMed , DOI )

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Manando Nakasaki, Kiyoko Yoshioka, Yasuhide Miyamoto, Takehiko Sasaki, Hideki Yoshikawa, Kazuyuki Itoh: IGF-I secreted by osteoblasts acts as a potent chemotactic factor for osteoblasts BONE. 2008.11; 43 (5): 869-879. ( PubMed , DOI )

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Yanfeng Wang, Xinsheng Chen, Lurong Lian, Tang Tang, Timothy J Stalker, Takehiko Sasaki, Yasunori Kanaho, Lawrence F Brass, John K Choi, John H Hartwig, Charles S Abrams: Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. Proc. Natl. Acad. Sci. U.S.A.. 2008.09; 105 (37): 14064-14069. ( PubMed , DOI )

Shinya Takahashi, Yasuhiro Araki, Yuriko Ohya, Takeshi Sakuno, Shin-Ichi Hoshino, Kenji Kontani, Hiroshi Nishina, Toshiaki Katada: Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast. RNA. 2008.09; 14 (9): 1950-1958. ( PubMed , DOI )

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Tae Inoue-Narita, Koichi Hamada, Takehiko Sasaki, Sachiko Hatakeyama, Sachiko Fujita, Kohichi Kawahara, Masato Sasaki, Hiroyuki Kishimoto, Satoshi Eguchi, Itaru Kojima, Friedrich Beermann, Tetsunori Kimura, Masatake Osawa, Satoshi Itami, Tak Wah Mak, Toru Nakano, Motomu Manabe, Akira Suzuki: Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis. Cancer Res.. 2008.07; 68 (14): 5760-5768. ( PubMed , DOI )

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Inagaki R, Tagawa K, Qi ML, Enokido Y, Ito H, Tamura T, Shimizu S, Oyanagi K, Arai N, Kanazawa I, Wanker EE, Okazawa H: Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease. Eur. J. Neurosci. 2008.07; 28 (1): 30-40. ( PubMed , DOI )

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Fumi Miyagawa, Yutaka Tagaya, Brian S Kim, Hiral J Patel, Kazuto Ishida, Toshiaki Ohteki, Thomas A Waldmann, Stephen I Katz: IL-15 serves as a costimulator in determining the activity of autoreactive CD8 T cells in an experimental mouse model of graft-versus-host-like disease. J Immunol. 2008.07; 181 (2): 1109-1119. ( PubMed )

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Hirohide Iwasaki, Yoshimichi Murata, Youngjun Kim, Md Israil Hossain, Carolyn A Worby, Jack E Dixon, Thomas McCormack, Takehiko Sasaki, Yasushi Okamura: A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc. Natl. Acad. Sci. U.S.A.. 2008.06; 105 (23): 7970-7975. ( PubMed , DOI )

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Magali Terme, Nathalie Chaput, Behazine Combadiere, Averil Ma, Toshiaki Ohteki, Laurence Zitvogel: Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells. J Immunol. 2008.04; 180 (7): 4679-4686. ( PubMed )

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Fabien Garçon, Daniel T Patton, Juliet L Emery, Emilio Hirsch, Robert Rottapel, Takehiko Sasaki, Klaus Okkenhaug: CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer. Blood. 2008.02; 111 (3): 1464-1471. ( PubMed , DOI )

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Yutaka Furutani, Hitomi Matsuno, Miwa Kawasaki, Takehiko Sasaki, Kensaku Mori, Yoshihiro Yoshihara: Interaction between telencephalin and ERM family proteins mediates dendritic filopodia formation JOURNAL OF NEUROSCIENCE. 2007.08; 27 (33): 8866-8876. ( PubMed , DOI )

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Yang Sung-Sen, Morimoto Tetsuji, Rai Tatemitsu, Chiga Motoko, Sohara Eisei, Ohno Mayuko, Uchida Keiko, Lin Shih-Hua, Moriguchi Tetsuo, Shibuya Hiroshi, Kondo Yoshiaki, Sasaki Sei, Uchida Shinichi: Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab. 2007.05; 5 (5): 331-344. ( PubMed , DOI )

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Naomi Hosogai, Atsunori Fukuhara, Kazuya Oshima, Yugo Miyata, Sachiyo Tanaka, Katsumori Segawa, Shigetada Furukawa, Yoshihiro Tochino, Ryutaro Komuro, Morihiro Matsuda, Iichiro Shimomura: Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes. 2007.04; 56 (4): 901-911. ( PubMed , DOI )

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Nobuhisa Ikuo, Ohtsu Naoki, Okada Seiji, Nakagata Naomi, Taga Tetsuya: Identification of a population of cells with hematopoietic stem cell properties in mouse aorta-gonad-mesonephros cultures. Exp Cell Res. 2007.03; 313 (5): 965-974. ( PubMed , DOI )

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Miwa Hebiguchi, Makoto Hirokawa, Yong-Mei Guo, Yoshinari Kawabata, Atsushi Komatsuda, Takehiko Sasaki, Yuichi Takakuwa, Ken-ichi Sawada: Enucleation of human erythroblasts is a process of asymmetric cytokinesis. BLOOD. 2006.11; 108 (11): 474A.

Katsumori Segawa, Atsunori Fukuhara, Naomi Hosogai, Kentaro Morita, Yosuke Okuno, Masaki Tanaka, Yasuhiko Nakagawa, Shinji Kihara, Tohru Funahashi, Ryutaro Komuro, Morihiro Matsuda, Iichiro Shimomura: Visfatin in adipocytes is upregulated by hypoxia through HIF1alpha-dependent mechanism. Biochem Biophys Res Commun. 2006.10; 349 (3): 875-882. ( PubMed , DOI )

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Toshiaki Ohteki, Hiroyuki Tada, Kazuto Ishida, Taku Sato, Chikako Maki, Taketo Yamada, Junji Hamuro, Shigeo Koyasu: Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo. J Exp Med. 2006.10; 203 (10): 2329-2338. ( PubMed , DOI )

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Kagawa Tetsushi, Shimizu Takeshi, Inoue Toshihiro, Yoshinaga Yutaka, Taga Tetsuya: 増殖中の神経前駆細胞から分化する神経細胞へ転換する分子機構(A molecular basis of transition from proliferating neural precursor cells to differentiating neurons) 神経化学. 2006.08; 45 (2-3): 337. ( ichushi )

Yuya Kunisaki, Akihiko Nishikimi, Yoshihiko Tanaka, Ryosuke Takii, Mayuko Noda, Ayumi Inayoshi, Ken-ichi Watanabe, Fumiyuki Sanematsu, Takehiko Sasazuki, Takehiko Sasaki, Yoshinori Fukui: DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis. J. Cell Biol.. 2006.08; 174 (5): 647-652. ( PubMed , DOI )

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Nakashima Kinichi, Kohyma Jun, Taga Tetsuya, Namihira Masakazu: 神経幹細胞の星状膠細胞分化能のノッチ-誘発性獲得(Notch-induced acquisition of astrocyte differentiation potential of neural stem cells) Neuroscience Research. 2006.07; 55 (Suppl.1): S36. ( ichushi )

Min Zhao, Bing Song, Jin Pu, Teiji Wada, Brian Reid, Guangping Tai, Fei Wang, Aihua Guo, Petr Walczysko, Yu Gu, Takehiko Sasaki, Akira Suzuki, John V Forrester, Henry R Bourne, Peter N Devreotes, Colin D McCaig, Josef M Penninger: Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature. 2006.07; 442 (7101): 457-460. ( PubMed , DOI )

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Daiju Kitagawa, Hiroaki Kajiho, Takahiro Negishi, Seiji Ura, Tomomi Watanabe, Teiji Wada, Hidenori Ichijo, Toshiaki Katada, Hiroshi Nishina: Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation. EMBO J.. 2006.07; 25 (14): 3286-3297. ( PubMed , DOI )

Seiichi Kuwajima, Taku Sato, Kazuto Ishida, Hiroyuki Tada, Hiroyuki Tezuka, Toshiaki Ohteki: Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation. Nat Immunol. 2006.07; 7 (7): 740-746. ( PubMed , DOI )

Tsuchiya Yuko, Kinoshita Kengo, Ito Nobutoshi, Nakamura Haruki: PreBI: prediction of biological interfaces of proteins in crystals. Nucleic Acids Res. 2006.07; 34 (Web Server issue): W320-W324. ( PubMed , DOI )

Noriko Kitanaka, Yuji Owada, Ryuhei Okuyama, Hiroyuki Sakagami, Mohammad Reza Nourani, Setsuya Aiba, Hiroshi Furukawa, Makoto Watanabe, Masao Ono, Toshiaki Ohteki, Hisatake Kondo: Epidermal-type fatty acid binding protein as a negative regulator of IL-12 production in dendritic cells. Biochem Biophys Res Commun. 2006.06; 345 (1): 459-466. ( PubMed , DOI )

Wataru Sato, Yasuo Horie, Ei Kataoka, Shigetoshi Ohshima, Takahiro Dohmen, Masahiro Iizuka, Junko Sasaki, Takehiko Sasaki, Koichi Hamada, Hiroyuki Kishimoto, Akira Suzuki, Sumio Watanabe: Hepatic gene expression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge. Hepatol. Res.. 2006.04; 34 (4): 256-265. ( PubMed , DOI )

Yoshimura N, Horiuchi D, Shibata M, Saitoe M, Qi ML, Okazawa H: Expression of human PQBP-1 in Drosophila impairs long-term memory and induces abnormal courtship. FEBS Lett. 2006.04; 580 (9): 2335-2340. ( PubMed , DOI )

Tabu K, Ohnishi A, Sunden Y, Suzuki T, Tsuda M, Tanaka S, Sakai T, Nagashima K, Sawa H: A novel function of OLIG2 to suppress human glial tumor cell growth via p27Kip1 transactivation. Journal of cell science. 2006.04; 119 (Pt 7): 1433-41. ( PubMed , DOI )

Yuichiro Yokoyama, Shuji Terai, Tsuyoshi Ishikawa, Koji Aoyama, Yohei Urata, Yoshio Marumoto, Hiroshi Nishina, Kazuyuki Nakamura, Kiwamu Okita, Isao Sakaida: Proteomic analysis of serum marker proteins in recipient mice with liver cirrhosis after bone marrow cell transplantation. Proteomics. 2006.04; 6 (8): 2564-2570. ( PubMed , DOI )

Akagawa M, Ito S, Toyoda K, Ishii Y, Tatsuda E, Shibata T, Yamaguchi S, Kawai Y, Ishino K, Kishi Y, Adachi T, Tsubata T, Takasaki Y, Hattori N, Matsuda T, Uchida K: Bispecific abs against modified protein and DNA with oxidized lipids. Proc Natl Acad Sci U S A. 2006.04; 103 (16): 6160-6165. ( PubMed , DOI )

Takizawa Hitoshi, Kubo-Akashi Chiyomi, Nobuhisa Ikuo, Kwon Sang-Mo, Iseki Masanori, Taga Tetsuya, Takatsu Kiyoshi, Takaki Satoshi: Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk. Blood. 2006.04; 107 (7): 2968-2975. ( PubMed , DOI )

Abematsu Masahiko, Kagawa Tetsushi, Fukuda Shinji, Inoue Toshihiro, Takebayashi Hirohide, Komiya Setsuro, Taga Tetsuya: Basic fibroblast growth factor endows dorsal telencephalic neural progenitors with the ability to differentiate into oligodendrocytes but not gamma-aminobutyric acidergic neurons. J Neurosci Res. 2006.04; 83 (5): 731-743. ( PubMed , DOI )

Singh Savita Devi, Hiroyuki Hagiyama, Takahiro Adachi, Nobuyuki Miyasaka, Takeshi Tsubata: The tumor suppressor p53 is not required for antigen receptor-mediated apoptosis of B lymphocytes Signal Transduction. 2006.02; 6 (1): 54-61. ( DOI )

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Honma M, Higuchi O, Shirakata M, Yasuda T, Shibuya H, Iemura S, Natsume T, Yamanashi Y: Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases. Genes Cells. 2006.02; 11 (2): 143-151. ( PubMed , DOI )

Tsuyoshi Ishikawa, Shuji Terai, Yohei Urata, Yoshio Marumoto, Koji Aoyama, Isao Sakaida, Tomoaki Murata, Hiroshi Nishina, Koh Shinoda, Shunji Uchimura, Yoshihiko Hamamoto, Kiwamu Okita: Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes. Cell Tissue Res.. 2006.02; 323 (2): 221-231. ( PubMed , DOI )

Inoue Toshihiro, Kagawa Tetsushi, Fukushima Mikiko, Shimizu Takeshi, Yoshinaga Yutaka, Takada Shinji, Tanihara Hidenobu, Taga Tetsuya: Activation of canonical Wnt pathway promotes proliferation of retinal stem cells derived from adult mouse ciliary margin. Stem Cells. 2006.01; 24 (1): 95-104. ( PubMed , DOI )

Teiji Wada, Tomoki Nakashima, Nishina Hiroshi, Josef M Penninger: RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends Mol Med. 2006.01; 12 (1): 17-25. ( PubMed , DOI )

Yanagisawa Makoto, Taga Tetsuya, Nakamura Kazuo, Ariga Toshio, Yu Robert K: Characterization of glycoconjugate antigens in mouse embryonic neural precursor cells. J Neurochem. 2005.12; 95 (5): 1311-1320. ( PubMed , DOI )

Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H: WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J Biol Chem. 2005.12; 280 (52): 42685-42693. ( PubMed , DOI )

Isao Sakaida, Shuji Terai, Hiroshi Nishina, Kiwamu Okita: Development of cell therapy using autologous bone marrow cells for liver cirrhosis. Med Mol Morphol. 2005.12; 38 (4): 197-202. ( PubMed , DOI )

Hiroyuki Tada, Setsuya Aiba, Ken-Ichiro Shibata, Toshiaki Ohteki, Haruhiko Takada: Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells. Infect Immun. 2005.12; 73 (12): 7967-7976. ( PubMed , DOI )

Hagihara K, Nishikawa T, Sugamata Y, Song J, Isobe T, Taga T, Yoshizaki K: Essential role of STAT3 in cytokine-driven NF-kappaB-mediated serum amyloid A gene expression. Genes to cells : devoted to molecular & cellular mechanisms. 2005.11; 10 (11): 1051-63. ( PubMed , DOI )

Enokido Y, Suzuki E, Iwasawa K, Namekata K, Okazawa H, Kimura H: Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS FASEB J. 2005.11; 19 (13): 1854-1856. ( PubMed , DOI )

Marubuchi S, Wada Y, Okuda T, Hara Y, Qi ML, Hoshino M, Nakagawa M, Kanazawa I, Okazawa H: PQBP -1 dysfunction induces cell death of neurons through mitochondrial stress. J Neurochem. 2005.11; 95 (3): 858-870. ( PubMed , DOI )

Masataka Asagiri, Kojiro Sato, Takako Usami, Sae Ochi, Hiroshi Nishina, Hiroki Yoshida, Ikuo Morita, Erwin F Wagner, Tak W Mak, Edgar Serfling, Hiroshi Takayanagi: Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J. Exp. Med.. 2005.11; 202 (9): 1261-1269. ( PubMed , DOI )

Yanagisawa Makoto, Nakashima Kinichi, Ochiai Wataru, Takizawa Takumi, Setoguchi Takao, Uemura Atsumi, Takizawa Makiko, Nobuhisa Ikuo, Taga Tetsuya: 凝集培養による海馬星状膠細胞の神経細胞系統への運命切り換え(Fate redirection of hippocampal astrocytes toward neuronal lineage by aggregate culture) Neuroscience Research. 2005.10; 53 (2): 176-182. ( ichushi )

Yanagisawa Makoto, Nakashima Kinichi, Ochiai Wataru, Takizawa Takumi, Setoguchi Takao, Uemura Atsumi, Takizawa Makiko, Nobuhisa Ikuo, Taga Tetsuya: Fate redirection of hippocampal astrocytes toward neuronal lineage by aggregate culture. Neurosci Res. 2005.10; 53 (2): 176-182. ( PubMed , DOI )

Yanagisawa Makoto, Nakamura Kazuo, Taga Tetsuya: Glycosphingolipid synthesis inhibitor represses cytokine-induced activation of the Ras-MAPK pathway in embryonic neural precursor cells. J Biochem. 2005.09; 138 (3): 285-291. ( PubMed , DOI )

Mawatari Yuki, Fukushima Mikiko, Inoue Toshihiro, Setoguchi Takao, Taga Tetsuya, Tanihara Hidenobu: Preferential differentiation of neural progenitor cells into the glial lineage through gp130 signaling in N-methyl-D-aspartate-treated retinas. Brain Res. 2005.09; 1055 (1-2): 7-14. ( PubMed , DOI )

Koichi Hamada, Takehiko Sasaki, Pandelakis A Koni, Miyuki Natsui, Hiroyuki Kishimoto, Junko Sasaki, Nobuyuki Yajima, Yasuo Horie, Go Hasegawa, Makoto Naito, Jun-Ichi Miyazaki, Toshio Suda, Hiroshi Itoh, Kazuwa Nakao, Tak Wah Mak, Toru Nakano, Akira Suzuki: The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev.. 2005.09; 19 (17): 2054-2065. ( PubMed , DOI )

Qi Y, Hoshino M, Wada Y, Marubuchi S, Yoshimura N, Kanazawa I, Shinomiya K, Okazawa H: PQBP-1 is expressed predominantly in the central nervous system during development. Eur J Neurosci. 2005.09; 22 (6): 1277-1286. ( PubMed , DOI )

Yanagisawa Makoto, Nakamura Kazuo, Taga Tetsuya: Glycosphingolipid合成阻害剤は胚性神経前駆細胞においてRas-MAPK経路のサイトカイン誘導活性化を抑制する(Glycosphingolipid Synthesis Inhibitor Represses Cytokine-Induced Activation of the Ras-MAPK Pathway in Embryonic Neural Precursor Cells) The Journal of Biochemistry. 2005.09; 138 (3): 285-291. ( ichushi )

波平 昌一, 神山 淳, 田賀 哲也, 中島 欽一: 神経幹細胞の発生・維持の分子機構　星状細胞特異的遺伝子プロモーターにおける脱メチル化の促進がNotchシグナル伝達によりもたらされる(Accelerated demethylation in an astrocyte specific gene promoter mediated by Notch-signaling) 神経化学. 2005.08; 44 (2-3): 169. ( ichushi )

清水 健史, 鹿川 哲史, 井上 俊洋, 吉永 豊, 田賀 哲也: 繊維芽細胞増殖因子2はグリコーゲン合成酵素キナーゼ3βを不活性化することによって未分化状体の神経幹細胞を維持し増殖を促進する(Fibroblast growth factor 2 maintains neural stem cells in an undifferentiated state and promotes their proliferation via the glycogen synthase kinase 3β inactivation) 神経化学. 2005.08; 44 (2-3): 224. ( ichushi )

Ohnishi J, Ohnishi E, Shibuya H, Takahashi T: Functions for proteinases in the ovulatory process. Biochim Biophys Acta. 2005.08; 1751 (1): 95-109. ( PubMed , DOI )

鹿川 哲史, 吉永 豊, 清水 健史, 井上 俊洋, 田賀 哲也: Wnt-3aは神経幹細胞の増殖と海馬発達に際しての神経細胞分化を共に促進する(Wnt-3a promotes both neural progenitor proliferation and neuronal differentiation during hippocampal development) 神経化学. 2005.08; 44 (2-3): 184. ( ichushi )

Taga Tetsuya, Kagawa Tetsushi, Fukuda Shinji, Shimizu Takeshi, Inoue Toshihiro: サイトカインシグナルは神経発達における細胞運命決定に関与する(Cytokine signals involved in cell fate determination during neural development) Neuroscience Research. 2005.07; 52 (Suppl.): S38. ( ichushi )

Namihira Masakazu, Aonuma Makoto, Setoguchi Hiroki, Kohyama Jun, Taga Tetsuya, Nakashima Kinichi: Notch誘発DNA脱メチル化は神経幹細胞の運命決定に関与する(Notch-induced DNA demethylation involved in fate determination of neural stem cells) Neuroscience Research. 2005.07; 52 (Suppl.): S67. ( ichushi )

Taga Tetsuya, Fukuda Shinji: Role of IL-6 in the neural stem cell differentiation. Clin Rev Allergy Immunol. 2005.06; 28 (3): 249-256. ( PubMed , DOI )

Taro Takami, Shuji Terai, Yuichiro Yokoyama, Haruko Tanimoto, Kunihiko Tajima, Koichi Uchida, Takahiro Yamasaki, Isao Sakaida, Hiroshi Nishina, Snorri S Thorgeirsson, Kiwamu Okita: Human homologue of maid is a useful marker protein in hepatocarcinogenesis. Gastroenterology. 2005.05; 128 (5): 1369-1380. ( PubMed )

Shimozaki Koji, Namihira Masakazu, Nakashima Kinichi, Taga Tetsuya: Stage- and site-specific DNA demethylation during neural cell development from embryonic stem cells. J Neurochem. 2005.04; 93 (2): 432-439. ( PubMed , DOI )

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Fukuda Shinji, Taga Tetsuya: 発達期マウスの脳における転写シグナル系によって制御される細胞発生運命の決定(Cell fate determination regulated by a transcriptional signal network in the developing mouse brain) Anatomical Science International. 2005.03; 80 (1): 12-18. ( ichushi )

Fukuda Shinji, Taga Tetsuya: Cell fate determination regulated by a transcriptional signal network in the developing mouse brain. Anat Sci Int. 2005.03; 80 (1): 12-18. ( PubMed , DOI )

Junko Sasaki, Takehiko Sasaki, Masakazu Yamazaki, Kunie Matsuoka, Choji Taya, Hiroshi Shitara, Shunsuke Takasuga, Miki Nishio, Katsunori Mizuno, Teiji Wada, Hideyuki Miyazaki, Hiroshi Watanabe, Ryota Iizuka, Shuichi Kubo, Shigeo Murata, Tomoki Chiba, Tomohiko Maehama, Koichi Hamada, Hiroyuki Kishimoto, Michael A Frohman, Keiji Tanaka, Josef M Penninger, Hiromichi Yonekawa, Akira Suzuki, Yasunori Kanaho: Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J. Exp. Med.. 2005.03; 201 (6): 859-870. ( PubMed , DOI )

Kota Saito, Yasuhiro Araki, Kenji Kontani, Hiroshi Nishina, Toshiaki Katada: Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin. J. Biochem.. 2005.03; 137 (3): 423-430. ( PubMed , DOI )

Fukuda Shinji, Taga Tetsuya: 中枢神経系の発達および再生中の神経幹細胞の制御(Regulation of neural stem cells during development and regeneration of the central nervous system) 炎症・再生. 2005.01; 25 (1): 18-25. ( ichushi )

Shuji Terai, Isao Sakaida, Hiroshi Nishina, Kiwamu Okita: Lesson from the GFP/CCl4 model--translational research project: the development of cell therapy using autologous bone marrow cells in patients with liver cirrhosis. J Hepatobiliary Pancreat Surg. 2005; 12 (3): 203-207. ( PubMed , DOI )

Kota Saito, Hiroaki Kajiho, Yasuhiro Araki, Hiroshi Kurosu, Kenji Kontani, Hiroshi Nishina, Toshiaki Katada: Purification and analysis of RIN family-novel Rab5 GEFs. Meth. Enzymol.. 2005; 403 276-283. ( PubMed , DOI )

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Toshiaki Ohteki: Critical role for IL-15 in innate immunity. Curr Mol Med. 2002.06; 2 (4): 371-380. ( PubMed )

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Kimura Naoki, Takizawa Makiko, Okita Keisuke, Natori Osamu, Igarashi Katsuhide, Ueno Masaya, Nakashima Kin-ichi, Nobuhisa Ikuo, Taga Tetsuya: Identification of a novel transcription factor, ELYS, expressed predominantly in mouse foetal haematopoietic tissues. Genes Cells. 2002.04; 7 (4): 435-446. ( PubMed )

Uemura Atsumi, Takizawa Takumi, Ochiai Wataru, Yanagisawa Makoto, Nakashima Kinichi, Taga Tetsuya: Cardiotrophin-like cytokine induces astrocyte differentiation of fetal neuroepithelial cells via activation of STAT3. Cytokine. 2002.04; 18 (1): 1-7. ( PubMed )

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Connie Krawczyk, Antonio Oliveira-dos-Santos, Takehiko Sasaki, Emily Griffiths, Pamela S Ohashi, Scott Snapper, Fred Alt, Josef M Penninger: Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity. 2002.03; 16 (3): 331-343. ( PubMed )

Kristine M Garza, Kim J McKall-Faienza, Toshiaki Otheki, Arsen Zakarian, Bernhard Odermatt, Pamela S Ohashi: Enhanced T cell responses contribute to the genetic predisposition of CD8-mediated spontaneous autoimmunity. Eur J Immunol. 2002.03; 32 (3): 885-894. ( PubMed , DOI )

Y Mizuno, Y Sotomaru, Y Katsuzawa, T Kono, M Meguro, M Oshimura, J Kawai, Y Tomaru, H Kiyosawa, Nikaido, I, H Amanuma, Y Hayashizaki, Y Okazaki: Asb4, Ata3, and Dcn are novel imprinted genes identified by high-throughput screening using RIKEN cDNA microarray BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2002.02; 290 (5): 1499-1505. ( PubMed , DOI )

Yanagisawa Makoto, Takizawa Takumi, Ochiai Wataru, Uemura Atsumi, Nakashima Kinichi, Taga Tetsuya: 神経上皮細胞の神経発生の骨形態形成蛋白による星細胞発生への変化(Fate alteration of neuroepithelial cells from neurogenesis to astrocytogenesis by bone morphogenetic proteins) Neuroscience Research. 2001.12; 41 (4): 391-396. ( ichushi )

Takizawa T, Nakashima K, Namihira M, Ochiai W, Uemura A, Yanagisawa M, Fujita N, Nakao M, Taga T: DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. Dev Cell. 2001.12; 1 (6): 749-758. ( PubMed )

Yanagisawa M, Takizawa T, Ochiai W, Uemura A, Nakashima K, Taga T: Fate alteration of neuroepithelial cells from neurogenesis to astrocytogenesis by bone morphogenetic proteins. Neurosci Res. 2001.12; 41 (4): 391-396. ( PubMed )

Yanagisawa M, Nakashima K, Takeda K, Ochiai W, Takizawa T, Ueno M, Takizawa M, Shibuya H, Taga T: Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7. Genes Cells. 2001.12; 6 (12): 1091-1099. ( PubMed )

HK Yum, J Arcaroli, J Kupfner, R Shenkar, JM Penninger, T Sasaki, KY Yang, JS Park, E Abraham: Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury JOURNAL OF IMMUNOLOGY. 2001.12; 167 (11): 6601-6608. ( PubMed , DOI )

T Ohteki, K Suzue, C Maki, T Ota, S Koyasu: Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response. Nat Immunol. 2001.12; 2 (12): 1138-1143. ( PubMed , DOI )

Yanagisawa M, Nakashima K, Takeda K, Ochiai W, Takizawa T, Ueno M, Takizawa M, Shibuya H, Taga T: Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7 GENES TO CELLS. 2001.12; 6 (12): 1091-1099.

T Sasaki, J Sasaki-Irie, J M Penninger: New insights into the transmembrane protein tyrosine phosphatase CD45. Int. J. Biochem. Cell Biol.. 2001.11; 33 (11): 1041-1046. ( PubMed )

R Hirose, H Okumura, A Yoshimatsu, J Irie, Y Onoda, Y Nomoto, H Takai, T Ohno, M Ichimura: KF31327, a new potent and selective inhibitor of cyclic nucleotide phosphodiesterase 5. Eur. J. Pharmacol.. 2001.11; 431 (1): 17-24. ( PubMed )

Shirakabe K, Terasawa K, Miyama K, Shibuya H, Nishida E: Regulation of the activity of the transcription factor Runx2 by two homeobox proteins, Msx2 and Dlx5. Genes Cells. 2001.10; 6 (10): 851-856. ( PubMed )

Fujita Yoshihiko, Ito Hiroe, Iino Ryota, Taga Tetsuya, Kusumi Akihiro: インターロイキン6刺激後のGP130シグナル複合体とアクチンフィラメントの相互作用　単一フルオロフォア動画像(INTERACTION OF GP130 SIGNALING COMPLEX WITH ACTIN FILAMENT AFTER INTERLEUKIN-6 STIMULATION: ANALYSIS BY SINGLE FLUOROPHORE DYNAMIC IMAGING) Cell Structure and Function. 2001.10; 26 (5): 451. ( ichushi )

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Ueno M, Igarashi K, Kimura N, Okita K, Takizawa M, Nobuhisa I, Kojima T, Kitamura T, Samulowitz U, Vestweber D, Shimomura T, Suda T, Nakashima K, Taga T: Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion. Biochem Biophys Res Commun. 2001.09; 287 (2): 501-506. ( PubMed , DOI )

T Sasaki, T Wada, H Kishimoto, J Irie-Sasaki, G Matsumoto, T Goto, Z Yao, A Wakeham, T W Mak, A Suzuki, S K Cho, J C Zuniga-Pflucker, A J Oliveira-dos-Santos, T Katada, H Nishina, J M Penninger: The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells. J. Exp. Med.. 2001.09; 194 (6): 757-768. ( PubMed )

Teiji Wada, Kentaro Nakagawa, Tomomi Watanabe, Gen Nishitai, Jungwon Seo, Hiroyuki Kishimoto, Daiju Kitagawa, Takehiko Sasaki, Josef M. Penninger, Hiroshi Nishina, Toshiaki Katada: Impaired synergistic activation of stress-activated protein kinase SAPK/ JNK in mouse embryonic stem cells lacking SEK1/MKK4: Different contribution of SEK2/MKK7 isoforms to the synergistic activation Journal of Biological Chemistry. 2001.08; 276 (33): 30892-30897. ( PubMed , DOI )

Choi MW, Yamamoto K, Masuno H, Nakashima K, Taga T, Yamada S: Ligand recognition by the vitamin D receptor BIOORGANIC & MEDICINAL CHEMISTRY. 2001.07; 9 (7): 1721-1730.

Adachi T, Wienands J, Wakabayashi C, Yakura H, Reth M, Tsubata T: SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates. J Biol Chem. 2001.07; 276 (28): 26648-26655. ( PubMed , DOI )

Choi M, Yamamoto K, Masuno H, Nakashima K, Taga T, Yamada S: Ligand recognition by the vitamin D receptor. Bioorganic & medicinal chemistry. 2001.07; 9 (7): 1721-30. ( PubMed , DOI )

Adachi T, Wienands J, Wakabayashi C, Yakura H, Reth M, Tsubata T: SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates JOURNAL OF BIOLOGICAL CHEMISTRY. 2001.07; 276 (28): 26648-26655.

Sugawara K, Morita K, Ueno N, Shibuya H: BIP, a BRAM-interacting protein involved in TGF-beta signalling, regulates body length in Caenorhabditis elegans. Genes Cells. 2001.07; 6 (7): 599-606. ( PubMed )

Higo J, Ito N, Kuroda M, Ono S, Nakajima N, Nakamura H: Energy landscape of a peptide consisting of alpha-helix, 3(10)-helix, beta-turn, beta-hairpin, and other disordered conformations. Protein Sci. 2001.06; 10 (6): 1160-1171. ( PubMed , DOI )

Ochiai W, Yanagisawa M, Takizawa T, Nakashima K, Taga T: Astrocyte differentiation of fetal neuroepithelial cells involving cardiotrophin-1-induced activation of STAT3. Cytokine. 2001.06; 14 (5): 264-271. ( PubMed , DOI )

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T Ohteki, C Maki, S Koyasu: Overexpression of Bcl-2 differentially restores development of thymus-derived CD4-8+ T cells and intestinal intraepithelial T cells in IFN-regulatory factor-1-deficient mice. J Immunol. 2001.06; 166 (11): 6509-6513. ( PubMed )

Ochiai W, Yanagisawa M, Takizawa T, Nakashima K, Taga T: Astrocyte differentiation of fetal neuroepithelial cells involving cardiotrophin-1-induced activation of STAT3 CYTOKINE. 2001.06; 14 (5): 264-271.

J M Penninger, J Irie-Sasaki, T Sasaki, A J Oliveira-dos-Santos: CD45: new jobs for an old acquaintance. Nat. Immunol.. 2001.05; 2 (5): 389-396. ( PubMed , DOI )

Nakashima K, Takizawa T, Ochiai W, Yanagisawa M, Hisatsune T, Nakafuku M, Miyazono K, Kishimoto T, Kageyama R, Taga T: BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis. Proc Natl Acad Sci U S A. 2001.05; 98 (10): 5868-5873. ( PubMed , DOI )

Ohnishi J, Ohnishi E, Jin M, Hirano W, Nakane D, Matsui H, Kimura A, Sawa H, Nakayama K, Shibuya H, Nagashima K, Takahashi T: Cloning and characterization of a rat ortholog of MMP-23 (matrix metalloproteinase-23), a unique type of membrane-anchored matrix metalloproteinase and conditioned switching of its expression during the ovarian follicular development. Mol Endocrinol. 2001.05; 15 (5): 747-764. ( PubMed )

Morita K, Shimizu M, Shibuya H, Ueno N: A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta signaling. Proc Natl Acad Sci U S A. 2001.05; 98 (11): 6284-6288. ( PubMed , DOI )

Goto T., Hasegawa K., Kinoshita T., Kubota H.Y.: A novel POZ/zinc finger protein, champignon, interferes with gastrulation movements in Xenopus. Dev. Dyn.. 2001.05; 221 14-25. ( PubMed , DOI )

A Suzuki, M T Yamaguchi, T Ohteki, T Sasaki, T Kaisho, Y Kimura, R Yoshida, A Wakeham, T Higuchi, M Fukumoto, T Tsubata, P S Ohashi, S Koyasu, J M Penninger, T Nakano, T W Mak: T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity. 2001.05; 14 (5): 523-534. ( PubMed )

Nakashima K, Takitawa T, Ochiai W, Yanagisawa M, Hisatsune T, Nakafuku M, Miyazono K, Kishimoto T, Kageyama R, Taga T: BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001.05; 98 (10): 5868-5873.

Noakes C.R., Goto T., Keller R., Periasamy A.: Does digital deconvolution improve two-photon microscopy in deep tissue imaging? Proc. SPIE. 2001.04; 4262 389-395. ( DOI )

Takizawa T, Yanagisawa M, Ochiai W, Yasukawa K, Ishiguro T, Nakashima K, Taga T: Directly linked soluble IL-6 receptor-IL-6 fusion protein induces astrocyte differentiation from neuroepithelial cells via activation of STAT3. Cytokine. 2001.03; 13 (5): 272-279. ( PubMed , DOI )

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Takizawa T, Yanagisawa M, Ochiai W, Yasukawa K, Ishiguro T, Nakashima K, Taga T: Directly linked soluble IL-6 receptor-IL-6 fusion protein induces astrocyte differentiation from neuroepithelial cells via activation of STAT3 CYTOKINE. 2001.03; 13 (5): 272-279.

C Bony, S Roche, U Shuichi, T Sasaki, M A Crackower, J Penninger, H Mano, M Pucéat: A specific role of phosphatidylinositol 3-kinase gamma. A regulation of autonomic Ca(2)+ oscillations in cardiac cells. J. Cell Biol.. 2001.02; 152 (4): 717-728. ( PubMed )

Masuda Y, Sasaki A, Shibuya H, Ueno N, Ikeda K, Watanabe K: Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function. J Biol Chem. 2001.02; 276 (7): 5331-5338. ( PubMed , DOI )

J Kawai, A Shinagawa, K Shibata, M Yoshino, M Itoh, Y Ishii, T Arakawa, A Hara, Y Fukunishi, H Konno, J Adachi, S Fukuda, K Aizawa, M Izawa, K Nishi, H Kiyosawa, S Kondo, Yamanaka, I, T Saito, Y Okazaki, T Gojobori, H Bono, T Kasukawa, R Saito, K Kadota, H Matsuda, M Ashburner, S Batalov, T Casavant, W Fleischmann, T Gaasterland, C Gissi, B King, H Kochiwa, P Kuehl, S Lewis, Y Matsuo, Nikaido, I, G Pesole, J Quackenbush, LM Schriml, F Staubli, R Suzuki, M Tomita, L Wagner, T Washio, K Sakai, T Okido, M Furuno, H Aono, R Baldarelli, G Barsh, J Blake, D Boffelli, N Bojunga, P Carninci, MF de Bonaldo, MJ Brownstein, C Bult, C Fletcher, M Fujita, M Gariboldi, S Gustincich, D Hill, M Hofmann, DA Hume, M Kamiya, NH Lee, P Lyons, L Marchionni, J Mashima, J Mazzarelli, P Mombaerts, P Nordone, B Ring, M Ringwald, Rodriguez, I, N Sakamoto, H Sasaki, K Sato, C Schonbach, T Seya, Y Shibata, KF Storch, H Suzuki, K Toyo-oka, KH Wang, C Weitz, C Whittaker, L Wilming, A Wynshaw-Boris, K Yoshida, Y Hasegawa, H Kawaji, S Kohtsuki, Y Hayashizaki: Functional annotation of a full-length mouse cDNA collection NATURE. 2001.02; 409 (6821): 685-690. ( PubMed , DOI )

Matsuo R, Ochiai W, Nakashima K, Taga T: A new expression cloning strategy for isolation of substrate-specific kinases by using phosphorylation site-specific antibody JOURNAL OF IMMUNOLOGICAL METHODS. 2001.01; 247 (1-2): 141-151.

T Ohteki, S Koyasu: Role of antigen-presenting cells in innate immune system. Arch Immunol Ther Exp (Warsz.). 2001.01; 49 Suppl 1 S47-S52. ( PubMed )

Matsuo R, Ochiai W, Nakashima K, Taga T: A new expression cloning strategy for isolation of substrate-specific kinases by using phosphorylation site-specific antibody. Journal of immunological methods. 2001.01; 247 (1-2): 141-51. ( PubMed , DOI )

J Irie-Sasaki, T Sasaki, W Matsumoto, A Opavsky, M Cheng, G Welstead, E Griffiths, C Krawczyk, C D Richardson, K Aitken, N Iscove, G Koretzky, P Johnson, P Liu, D M Rothstein, J M Penninger: CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature. 2001.01; 409 (6818): 349-354. ( PubMed , DOI )

S Clément, U Krause, F Desmedt, J F Tanti, J Behrends, X Pesesse, T Sasaki, J Penninger, M Doherty, W Malaisse, J E Dumont, Y Le Marchand-Brustel, C Erneux, L Hue, S Schurmans: The lipid phosphatase SHIP2 controls insulin sensitivity. Nature. 2001.01; 409 (6816): 92-97. ( PubMed , DOI )

T Tsubata, C Wakabayashi, T Adachi: Regulation of B-cell antigen receptor signaling by CD72 ACTIVATING AND INHIBITORY IMMUNOGLOBULIN-LIKE RECEPTORS. 2001; 123-128.

Kato Hiroaki, Chen Shi, Kiyama Hiroshi, Ikeda Ken, Kimura Naoki, Nakashima Kinichi, Taga Tetsuya: ニューロン発生時及び再生時に顕著に発現する,WDリピートを持つ新規遺伝子の同定 The Journal of Biochemistry. 2000.12; 128 (6): 923-932. ( ichushi )

Kato H, Chen S, Kiyama H, Ikeda K, Kimura N, Nakashima K, Taga T: Identification of a novel WD repeat-containing gene predominantly expressed in developing and regenerating neurons. J Biochem. 2000.12; 128 (6): 923-932. ( PubMed )

Shoji M, Iwakami N, Takeuchi S, Waragai M, Suzuki M, Kanazawa I, Lippa CF, Ono S, Okazawa H: JNK activation is associated with intracellular beta-amyloid accumulation. Brain Res Mol Brain Res. 2000.12; 85 (1-2): 221-233. ( PubMed , DOI )

Kato H, Chen S, Kiyama H, Ikeda K, Kimura N, Nakashima K, Taga T: Identification of a novel WD repeat-containing gene predominantly expressed in developing and regenerating neurons JOURNAL OF BIOCHEMISTRY. 2000.12; 128 (6): 923-932.

Kojima N, Kinoshita T, Kamiya A, Nakamura K, Nakashima K, Taga T, Miyajima A: Cell density-dependent regulation of hepatic development by a gp130-independent pathway. Biochem Biophys Res Commun. 2000.10; 277 (1): 152-158. ( PubMed , DOI )

C Krawczyk, K Bachmaier, T Sasaki, R G Jones, S B Snapper, D Bouchard, I Kozieradzki, P S Ohashi, F W Alt, J M Penninger: Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity. 2000.10; 13 (4): 463-473. ( PubMed )

AJ Oliveira-dos-Santos, G Matsumoto, BE Snow, DL Bai, FP Houston, IQ Whishaw, S Mariathasan, T Sasaki, A Wakeham, PS Ohashi, JC Roder, CA Barnes, DP Siderovski, JM Penninger: Regulation of T cell activation, anxiety, and male aggression by RGS2 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000.10; 97 (22): 12272-12277. ( PubMed , DOI )

Kojima N, Kinoshita T, Kamiya A, Nakamura K, Nakashima K, Taga T, Miyajima A: Cell density-dependent regulation of hepatic development by a gp 130-independent pathway BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000.10; 277 (1): 152-158.

Shin HI, Paola D, Bringhurst FR, Taga T, Suda T, Kronenberg H: gp130 is necessary for full PTH-induced osteoclastic differentiation and activation. JOURNAL OF BONE AND MINERAL RESEARCH. 2000.09; 15 S218.

J E Fata, Y Y Kong, J Li, T Sasaki, J Irie-Sasaki, R A Moorehead, R Elliott, S Scully, E B Voura, D L Lacey, W J Boyle, R Khokha, J M Penninger: The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell. 2000.09; 103 (1): 41-50. ( PubMed )

Ueno M, Kimura N, Nakashima K, Saito-Ohara F, Inazawa J, Taga T: Genomic organization, sequence and chromosomal localization of the mouse Tbr2 gene and a comparative study with Tbr1 GENE. 2000.08; 254 (1-2): 29-35.

T Sasaki, J Irie-Sasaki, Y Horie, K Bachmaier, JE Fata, M Li, A Suzuki, D Bouchard, A Ho, M Redston, S Gallinger, R Khokha, TW Mak, PT Hawkins, L Stephens, SW Scherer, M Tsao, JM Penninger: Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)K gamma NATURE. 2000.08; 406 (6798): 897-902. ( PubMed , DOI )

Waragai M, Junn E, Kajikawa M, Takeuchi S, Kanazawa I, Shibata M, Mouradian MM, Okazawa H: PQBP-1/Npw38, a nuclear protein binding to the polyglutamine tract, interacts with U5-15kD/dim1p via the carboxyl-terminal domain. Biochem Biophys Res Commun. 2000.07; 273 (2): 592-595. ( PubMed , DOI )

Hanafusa H, Masuyama N, Kusakabe M, Shibuya H, Nishida E: The TGF-beta family member derriere is involved in regulation of the establishment of left-right asymmetry. EMBO Rep. 2000.07; 1 (1): 32-39. ( PubMed , DOI )

Tago K, Nakamura T, Nishita M, Hyodo J, Nagai S, Murata Y, Adachi S, Ohwada S, Morishita Y, Shibuya H, Akiyama T: Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. Genes Dev. 2000.07; 14 (14): 1741-1749. ( PubMed )

T Ohteki, M Parsons, A Zakarian, R G Jones, L T Nguyen, J R Woodgett, P S Ohashi: Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3. J Exp Med. 2000.07; 192 (1): 99-104. ( PubMed )

Goto T. (corresponding author), Katada T., Kinoshita T., Kubota H.Y.: Expression and characterization of Xenopus type I collagen alpha 1 (COL1A1) during embryonic development. Dev. Growth Differ.. 2000.06; 42 249-256. ( PubMed )

Kimura N, Matsuo R, Shibuya H, Nakashima K, Taga T: BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. J Biol Chem. 2000.06; 275 (23): 17647-17652. ( PubMed , DOI )

Nikaido, I, E Asamizu, M Nakajima, Y Nakamura, N Saga, S Tabata: Generation of 10,154 expressed sequence tags from a leafy gametophyte of a marine red alga, Porphyra yezoensis DNA RESEARCH. 2000.06; 7 (3): 223-227. ( PubMed , DOI )

Kimura N, Matsuo R, Shibuya H, Nakashima K, Taga T: BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6 JOURNAL OF BIOLOGICAL CHEMISTRY. 2000.06; 275 (23): 17647-17652.

Takatsu Y, Nakamura M, Stapleton M, Danos MC, Matsumoto K, O'Connor MB, Shibuya H, Ueno N: TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development. Mol Cell Biol. 2000.05; 20 (9): 3015-3026. ( PubMed )

Yanagisawa M, Nakashima K, Arakawa H, Ikenaka K, Yoshida K, Kishimoto T, Hisatsune T, Taga T: Astrocyte differentiation of fetal neuroepithelial cells by interleukin-11 via activation of a common cytokine signal transducer, gp130, and a transcription factor, STAT3. J Neurochem. 2000.04; 74 (4): 1498-1504. ( PubMed )

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Yuta Ryoden, Toshihiro Fujii, Katsumori Segawa, Shigekazu Nagata: Functional Expression of the P2X7 ATP Receptor Requires Eros. Journal of immunology (Baltimore, Md. : 1950). 2020.02; 204 (3): 559-568. ( PubMed , DOI )

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Katsumori Segawa, Yuichi Yanagihashi, Kyoko Yamada, Chigure Suzuki, Yasuo Uchiyama, Shigekazu Nagata: Phospholipid flippases enable precursor B cells to flee engulfment by macrophages. Proceedings of the National Academy of Sciences of the United States of America. 2018.11; 115 (48): 12212-12217. ( PubMed , DOI )

安達 貴弘: 生体イメージングによる食シグナルおよび超早期未病の可視化解析 生体内のCa2+シグナルを見る 化学と生物. 2018.04; 56 (5): 345-352. ( ichushi )

安達貴弘: 生体イメージングによる食シグナルおよび超早期未病の可視化解析 生体内のCa²⁺シグナルを見る 化学と生物. 2018.04; 56 (5): 345‐352.

渡部 太郎, 永石 宇司, 細谷 明徳, Jose Nisha, 津川 直也, 小島 裕大, 安達 貴弘, 渡辺 守: intra-vital imagingによる実験腸炎モデルにおける回盲部免疫応答の解析 日本消化器病学会雑誌. 2018.04; 115 (臨増総会): A335. ( ichushi )

安達貴弘: 生体イメージングによる食シグナルの可視化解析 日本農芸化学会大会講演要旨集(Web). 2018.03; 2018 ROMBUNNO.4SY09‐1 (WEB ONLY).

Masashi Kanayama, Mari L. Shinohara: Balancing population sizes of myeloid and lymphoid cells by osteopontin isoforms 2018.03; 63 (3): 219-224.

津川直也, 永石宇司, 渡部太郎, 細谷明徳, NISHA Jose, 小島裕大, 安達貴弘, 渡辺守: IgAによる腸内細菌叢制御と腸管粘膜防御の検証 日本消化管学会雑誌. 2018.02; 2 (Suppl.): 265. ( ichushi )

Katsumori Segawa, Sachiko Kurata, Shigekazu Nagata: The CDC50A extracellular domain is required for forming a functional complex with and chaperoning phospholipid flippases to the plasma membrane Journal of Biological Chemistry. 2018.02; 293 (6): 2172-2182. ( PubMed , DOI )

Toshiaki Ohteki: Identification of a human progenitor strictly committed to monocytic differentiation: a counterpart of mouse cMoPs. Rinsho Ketsueki. 2018; 59 (6): 812-818. ( PubMed , DOI )

平石 萌, 小谷野 史香, 久永 眞市, 中田 和人, 田中 啓二, 松田 憲之: Parkin機能喪失に由来するパーキンソン病モデルマウスの作製と解析 生命科学系学会合同年次大会. 2017.12; 2017年度 [2P-1068]. ( ichushi )

小島 和華, 山野 晃史, 木村 まゆみ, Bruno Queliconi, 田中 啓二, 松田 憲之: DJ-1の局在解析から見出す非典型的ミトコンドリア局在化シグナル 生命科学系学会合同年次大会. 2017.12; 2017年度 [1P-0324]. ( ichushi )

佐藤 裕介, 尾勝 圭, 佐伯 泰, 山野 晃史, 松田 憲之, 海保 愛, 山形 敦史, 伊藤 桜子, 石川 稔, 橋本 祐一, 田中 啓二, 深井 周也: ユビキチン・コード:細胞内の最も難解な暗号を読む USP30によるLys6結合型ユビキチン鎖特異的切断機構の構造的基盤 生命科学系学会合同年次大会. 2017.12; 2017年度 [4AW13-6]. ( ichushi )

渡部太郎, 永石宇司, 津川直也, NISHA Jose, 細谷明徳, 小島裕大, 安達貴弘, 渡辺守: 回腸粘膜における防御機構としてのIgAの重要性 日本臨床免疫学会会誌. 2017.08; 40 (4): 297. ( ichushi )

永石宇司, 渡部太郎, 細谷明徳, NISHA Jose, 津川直也, 小島裕大, 安達貴弘, 渡辺守: 生体イメージングを応用したIBDモデルにおける腸管粘膜免疫応答の解析 日本臨床免疫学会会誌. 2017.08; 40 (4): 269-269b. ( DOI )

PINK1-PhosphoUbiquitin-Parkin axis for degradation of damaged mitochondria 2017.08; 262 (6): 603-608.

Yuichi Yanagihashi, Katsumori Segawa, Ryota Maeda, Yo-ichi Nabeshima, Shigekazu Nagata: Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017.08; 114 (33): 8800-8805. ( PubMed , DOI )

Sayuri Gyobu, Kenji Ishihara, Jun Suzuki, Katsumori Segawa, Shigekazu Nagata: Characterization of the scrambling domain of the TMEM16 family PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017.06; 114 (24): 6274-6279. ( PubMed , DOI )

渡部太郎, 永石宇司, NISHA Jose, 東海有沙, 細谷明徳, 小島裕大, 安達貴弘, 渡辺守: IgAの欠損は回腸粘膜特異的な炎症を誘発する 日本消化管学会総会学術集会プログラム・抄録集. 2017; 13th 252.

吉田雪子, 安田さや香, 藤田敏治, 濱崎万穂, 村上有沙, 川脇純子, 岩井一宏, 佐伯泰, 吉森保, 松田憲之, 田中啓二: SCF^FBXO27による損傷リソソームから細胞質へ露出した糖蛋白質のユビキチン化はリソファジーの引き金となる 日本生化学会大会(Web). 2017; 90th ROMBUNNO.4LT01‐08(3P‐0149) (WEB ONLY)-0149)]. ( ichushi )

松田憲之, 小谷野史香: Phos-Tag PAGE: uncovering the role of phosphorylation resisting Parkinson's disease 電気泳動(Web). 2015.10; 59 (2):

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Fumiko Toyoshima: Mechanisms for the oriented cell division in mammalian cells Seikagaku. 2012; 84 (2): 81-91. ( PubMed )

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Atsushi Tanaka, Taizo A Nakano, Masaki Nomura, Hiromi Yamazaki, Jan Philipp Bewersdorf, Roger Mulet-Lazaro, Simon Hogg, Bo Liu, Alex Vincent Penson, Akihiko Yokoyama, Weijia Zang, Marije Havermans, Miho Koizumi, Yasutaka Hayashi, Hana Cho, Akinori Kanai, Stanley C Lee, Muran Xiao, Yui Koike, Yifan Zhang, Miki Fukumoto, Yumi Aoyama, Tsuyoshi Konuma, Hiroyoshi Kunimoto, Toshiya Inaba, Hideaki Nakajima, Hiroaki Honda, Hiroshi Kawamoto, Ruud Delwel, Omar Abdel-Wahab, Daichi Inoue: Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia Blood. 2022.06; 140 (8): 875-888. ( DOI )

中西瑛太, CORNETTE Richard, 吉田祐貴, 新井智彦, 徳本翔子, 宮田佑吾, GUSEV Oleg, GUSEV Oleg, GUSEV Oleg, 黄川田隆洋, 黄川田隆洋: Genomic analysis of an acid-tolerant chironomid, Polypedilum sp. cf. tamanigrum, to reveal adaptation mechanisms to extremely acidic environments 日本分子生物学会年会プログラム・要旨集(Web). 2021; 44th

Shoko Tokumoto, Yugo Miyata, Kengo Usui, Ruslan Deviatiiarov, Takahiro Ohkawa, Sabina Kondratieva, Elena Shagimardanova, Oleg Gusev, Richard Cornette, Masayoshi Itoh, Yoshihide Hayashizaki, Takahiro Kikawada: Development of a Tet-On Inducible Expression System for the Anhydrobiotic Cell Line, Pv11 Insects. 2020.11; 11 (11): 781. ( DOI )

布施寛人, 宮田佑吾, CORNETTE Richard, 黄川田隆洋, 黄川田隆洋: Development of Real-time Ca²⁺ Imaging Method in Pv11 Cells Using Perfusion System 低温生物工学会誌. 2020; 66 (2):

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Sabina A. Kondratyeva, Alexander A. Nesmelov, Alexander V. Cherkasov, Yugo Miyata, Shoko Tokumoto, Takahiro Kikawada, Oleg A. Gusev, Elena I. Shagimardanova: Intracellular localization and gene expression analysis provide new insights on LEA proteins' diversity in anhydrobiotic midge bioRxiv. 2019.10; ( DOI )

Shuto Hayashi, Takuya Moriyama, Rui Yamaguchi, Shinichi Mizuno, Mitsuhiro Komura, Satoru Miyano, Hidewaki Nakagawa, Seiya Imoto: ALPHLARD-NT: Bayesian Method for Human Leukocyte Antigen Genotyping and Mutation Calling through Simultaneous Analysis of Normal and Tumor Whole-Genome Sequence Data Journal of Computational Biology. 2019.09; 26 (9): 923-937. ( DOI )

Miyata, Y., Tokumoto, S., Sogame, Y., Deviatiiarov, R., Okada, J., Cornette, R., Gusev, O., Shagimardanova, E., Sakurai, M., Kikawada, T.: Identification of a novel strong promoter from the anhydrobiotic midge, Polypedilum vanderplanki, with conserved function in various insect cell lines Scientific Reports. 2019; 9 (1): ( PubMed , DOI )

尾勝圭, 松田憲之, 深井周也: PINK1 activation by its unconventional localization to the outer mitochondrial membrane 日本分子生物学会年会プログラム・要旨集(Web). 2019; 42nd

Shuto Hayashi, Rui Yamaguchi, Shinichi Mizuno, Mitsuhiro Komura, Satoru Miyano, Hidewaki Nakagawa, Seiya Imoto: ALPHLARD: a Bayesian method for analyzing HLA genes from whole genome sequence data BMC Genomics. 2018.11; 19 (1): ( DOI )

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Shin Morioka, Kiyomi Nigorikawa, Kaoru Hazeki, Michiko Ohmura, Hiromi Sakamoto, Takuma Matsumura, Shunsuke Takasuga, Osamu Hazeki: Phosphoinositide phosphatase Sac3 regulates the cell surface expression of scavenger receptor A and formation of lipid droplets in macrophages Experimental Cell Research. 2017.08; 357 (2): 252-259. ( DOI )

Phosphatidylinositol-3,5-bisphosphate: metabolism and physiological functions. Journal of biochemistry. 2013.07; ( PubMed , DOI )

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Suzuki A, Itami S, Ohishi M, Hamada K, Inoue T, Komazawa N, Senoo H, Sasaki T, Takeda J, Manabe M, Mak TW, Nakano T: Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation. Cancer research. 2003.02; 63 674-681. ( PubMed )

Kishimoto H, Hamada K, Saunders M, Backman S, Sasaki T, Nakano T, Mak TW, Suzuki A: Physiological functions of Pten in mouse tissues. Cell structure and function. 2003.02; 28 (1): 11-21. ( PubMed , DOI )

Tsukasa Matsuda, Keiji Nishimura, Toshihiko Tsuda, Yukinari Takeuchi, Takahiro Adachi, Naohito Aoki, Ken Kitajima: Avian egg coat glycoproteins: Identification and characterisation of homologues of mammalian zona pellucida glycoproteins Zygote. 1998.12; 6

F. Toyoshima: Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint The EMBO Journal. 1998.05; 17 (10): 2728-2735. ( DOI )

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T. Moriguchi: A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses The EMBO Journal. 1997.12; 16 (23): 7045-7053. ( DOI )

H. Yamagata, T. Adachi, A. Tsuboi, M. Takao, T. Sasaki, N. Tsukagoshi, S. Udaka: Cloning and characterization of the 5' region of the cell wall protein gene operon in Bacillus brevis 47 Journal of Bacteriology. 1987.01; 169 1239-1245. ( DOI )