Organic and Medicinal Chemistry

115  articles.  
* There may be some overlapped articles listed due to the difference of format.

  1. Nhieu, J.; Milbauer, L.; Lerdall, T.; Najjar, F.; Wei, C.-W.; Ishida, R.; Ma, Y.; Kagechika, H.; Wei, L.-N.: Targeting Cellular Retinoic Acid Binding Protein 1 with Retinoic Acid-like Compounds to Mitigate Motor Neuron Degeneration Int. J. Mol. Sci.. 2023.03; 24 4980.

  1. Murayama, T.; Kurebayashi, N.; Numaga-Tomita, T.; Kobayashi, T.; Okazaki, S.; Yamashiro, K.; Nakada, T.; Mori, S.; Ishida, R.; Kagechika, H.; Yamada, M.; Sakurai, T.: A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery. J. Gen. Physiol.. 2022.12; 154 (12): e202213230. ( DOI )

  2. Tsuboi, Y.; Oyama, K.; Kobirumaki-Shimozawa, F.; Murayama, T.; Kurebayashi, N.; Tachibana, T.; Manome, Y.; Kikuchi, E.; Noguchi, S.; Inoue, T.; Inoue, Y. U.; Nishino, I.; Mori, S.; Ishida, R.; Kagechika, H.; Suzuki, M.; Fukuda, N.; Yamazawa, T.: Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes J. Gen. Physiol.. 2022.12; 154 e202213136.

  3. Yamada, S.; Masuno, H.; Kagechika, H.; Tanatani, A.; Kanda, Y: A Novel Lithocholic Acid Derivative Upregulates Detoxification-Related Genes in Human Induced Pluripotent Stem Cell-Derived Intestinal Organoids. Biol. Pharm. Bull.. 2022.11; 45 (1720): 1724.

  4. Ishida, R.; Mori, S.; Murayama, T.; Nakamichi, A.; Chai, X.; Kurebayashi, N. Iinuma, H.; Kagechika, H.: Development of a water-soluble ryanodine receptor 1 inhibitor. Bioorg. Med. Chem.. 2022.09; 74 117027. ( DOI )

  5. Mori, S.; Tsuemoto, N.; Kawachi, E.; Takubo, C.; Tanatani, A.; Kagechika, H.: Development of retinoic acid receptor antagonists bearing trans-SF4-alkynyl structure as a linear linker. Tetrahedron . 2022.08; 123 132967. ( DOI )

  6. Hara Y, Ando F, Oikawa D, Ichimura K, Yanagawa H, Sakamaki Y, Nanamatsu A, Fujiki T, Mori S, Suzuki S, Yui N, Mandai S, Susa K, Mori T, Sohara E, Rai T, Takahashi M, Sasaki S, Kagechika H, Tokunaga F, Uchida S: LRBA is essential for urinary concentration and body water homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 2022.07; 119 (30): e2202125119. ( PubMed , DOI )

  7. Hara, Y.; Ando, F.; Oikawa, D.; Ichimura, K.; Yanagawa, H.; Sakamaki, Y.; Nanamatsu, A.; Fujiki, T.; Mori, S.; Suzuki, S.; Yui, N.; Mandai, S.; Susa, K.; Mori, T.; Sohara, E.; Rai, T.; Takahashi, M.; Sasaki, S.; Kagechika, H.; Tokunaga, F.; Uchida, S.: LRBA is essential for urinary concentration and body water homeostasis Proc. Natl. Acad. Sci. USA. 2022.07; 119 (30): e2202125119.

  8. Oikawa, T.; Fujii, S.; Mori, S.; Masuno, H.; Kawachi, E.; Kagechika, H. : Structural Development of Silicon-Containing Retinoids: Structure–Activity Relationship Study of the Hydrophobic Pharmacophore of Retinobenzoic Acids Using Silyl Functionalities ChemMedChem. 2022.06; e202200176.

  9. Yoshihara, A.; Kawasaki, H.; Masuno, M.; Takada, K.; Numoto, N.; Ito, N.; Hirata, N.; Kanda, Y.; Ishizawa, M.; Makishima, M.; Kagechika, H.; Tanatani, A.: Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists Biomolecules. 2022.01; 12 (1): 130.

  10. Yoshihara Ayana, Kawasaki Haru, Masuno Hiroyuki, Takada Koki, Numoto Nobutaka, Ito Nobutoshi, Hirata Naoya, Kanda Yasunari, Ishizawa Michiyasu, Makishima Makoto, Kagechika Hiroyuki, Tanatani Aya: Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists BIOMOLECULES. 2022.01; 12 (1): ( PubMed , DOI )

  1. Takayanagi, S.; Watanabe, K.; Maruyama, T.; Ogawa, M.; Morishita, K.; Soga, M.; Hatta, T.; Natsume, T.; Hirano, T.; Kagechika, H.; Hattori, K.; Naguro, I.; Ichijo, H.: ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes Sci. Rep.. 2021.10; 11 22009.

  2. Fujii, S.; Kikuchi, E.; Suzuyama, H.; Watanabe, Y.; Ishigami-Yuasa, M.; Masuno, H.; Mori, T.; Isobe, K.; Uchida, S.; Kagechika, H.: Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents ChemMedChem. 2021.09; 16 (18): 2817-2822.

  3. Lin Liu, Hiroyuki Koike, Takehito Ono, Shinichiro Hayashi, Fujimi Kudo, Atsushi Kaneda, Hiroyuki Kagechika, Ichiro Manabe, Tomoki Nakashima, Yumiko Oishi: Identification of a KLF5-dependent program and drug development for skeletal muscle atrophy. Proc Natl Acad Sci U S A. 2021.08; 118 (35): ( PubMed , DOI )

  4. Fujii Shinya, Kikuchi Eriko, Suzuyama Honoka, Watanabe Yuko, Ishigami-Yuasa Mari, Masuno Hiroyuki, Mori Takayasu, Isobe Kiyoshi, Uchida Shinichi, Kagechika Hiroyuki: Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents CHEMMEDCHEM. 2021.07; 16 (18): 2817-2822. ( PubMed , DOI )

  5. Konishi, M.; Noguchi, S.; Inoue, T.; Inoue, Y. U.; Nishino, I.; Mori, S.; Iinuma, H.; Manaka, N.; Kagechika, H.; Uryash, A.; Adams, J.; Lopez, J. R.; Liu, X. C.; Diggle, C.; Allen, P. D.; Kakizawa, S.; Ikeda, K.; Lin, B. Z.; Ikemi, Y.; Nunomura, K.; Nakagawa, S.; Sakurai, T.; Murayama, T.: A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke Nature Commun.. 2021.07; 12 (1): 4293. ( DOI )

  6. Lin, Y.-W.; Nhieu, J.; Wei, C.-W.; Lin, Y.-L.; Kagechika, H.; Wei, L.-N.: Regulation of exosome secretion by cellular retinoic acid binding protein 1 contributes to systemic anti-inflammation Cell Commun. Signal.. 2021.06; 19 (1): 69. ( PubMed , DOI )

  7. Nagashima S, Maruyama J, Honda K, Kondoh Y, Osada H, Nawa M, Nakahama KI, Ishigami-Yuasa M, Kagechika H, Sugimura H, Iwasa H, Arimoto-Matsuzaki K, Nishina H, Hata Y: CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells. The Journal of biological chemistry. 2021.05; 297 (1): 100803. ( PubMed , DOI )

  8. Kato, D.; Shiraishi, T.; Kagechika, H.; Hirano, T.: Design, synthesis and antitumor activity of phthalazine-1,4-dione-based menaquinone analogs Bioorg. Med. Chem. Lett.. 2021.04; 43 128065. ( PubMed , DOI )

  9. Kato Daiki, Shiraishi Takuya, Kagechika Hiroyuki, Hirano Tomoya: 6-Arylcoumarin as a Scaffold of Photofunctional Molecules with OFF-ON-OFF Type Regulation JOURNAL OF ORGANIC CHEMISTRY. 2021.02; 86 (3): 2264-2270. ( PubMed , DOI )

  10. Cione, E.; Caroleo, M. C.; Kagechika, H.; Manetti, F.: Pharmacophore-guided repurposing of fibrates and retinoids as GPR40 allosteric ligands. J. Enzyme Inhibit. Med. Chem. 2021.02; 36 (1): 377-383. ( PubMed , DOI )

  11. Fujii, S.; Sekine, R.; Kano, A.; Masuno, H.; Kawachi, E.; Hirano, T.; Kagechika, H.: Synthesis and Structure-Activity Relationship Study of 1,12-Dicarba-closo-dodecaborane-based Triol Derivatives as Nonsecosteroidal Vitamin D Analogs Heterocycles. 2021; 103 (1): 444-458. ( DOI )

  12. Arimura, M.; Tanaka, K.; Kanda, M.; Urushibara, K.; Fujii, S.*; Katagiri, K.; Azumaya, I.; Kagechika, H.; Tanatani, A.: Construction of Aromatic Multilayered Structures Based on the Conformational Properties of N,N’-Dimethylated Squaramide ChemPlusChem. 2021; 86 (1): 198-205. ( PubMed , DOI )

  1. Sasaki H, Masuno H, Kawasaki H, Yoshihara A, Numoto N, Ito N, Ishida H, Yamamoto K, Hirata N, Kanda Y, Kawachi E, Kagechika H, Tanatani A: Lithocholic Acid Derivatives as Potent Vitamin D Receptor Agonists. Journal of medicinal chemistry. 2020.12; 64 (1): 516-526. ( PubMed , DOI )

  2. Sato Atsushi, Shimizu Masahiro, Goto Toshiyasu, Masuno Hiroyuki, Kagechika Hiroyuki, Tanaka Nobuyuki, Shibuya Hiroshi: WNK regulates Wnt signalling and beta-Catenin levels by interfering with the interaction between beta-Catenin and GID COMMUNICATIONS BIOLOGY. 2020.11; 3 (1): ( DOI )

  3. Sakakitani S, Podyma-Inoue KA, Takayama R, Takahashi K, Ishigami-Yuasa M, Kagechika H, Harada H, Watabe T: Activation of β2-adrenergic receptor signals suppresses mesenchymal phenotypes of oral squamous cell carcinoma cells. Cancer Science. 2020.10; ( PubMed , DOI )

  4. Fujii Shinya, Kikuchi Eriko, Watanabe Yuko, Suzuyama Honoka, Ishigami-Yuasa Mari, Mori Takayasu, Isobe Kiyoshi, Uchida Shinichi, Kagechika Hiroyuki: Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2020.09; 30 (17): 127408. ( PubMed , DOI )

  5. Erika Ishihara, Yuya Nagaoka, Toshiaki Okuno, Satoshi Kofuji, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Kenya Kamimura, Shuji Terai, Takehiko Yokomizo, Yukihiko Sugimoto, Yasuyuki Fujita, Akira Suzuki, Hiroshi Nishina: Prostaglandin E2 and its receptor EP2 trigger signaling that contributes to YAP-mediated cell competition. Genes Cells. 2020.03; 25 (3): 197-214. ( PubMed , DOI )

  6. Manami Kodaka, Fengju Mao, Kyoko Arimoto-Matsuzaki, Masami Kitamura, Xiaoyin Xu, Zeyu Yang, Kentaro Nakagawa, Junichi Maruyama, Kana Ishii, Chihiro Akazawa, Takuya Oyaizu, Naoki Yamamoto, Mari Ishigami-Yuasa, Nozomi Tsuemoto, Shigeru Ito, Hiroyuki Kagechika, Hiroshi Nishina, Yutaka Hata: Characterization of a novel compound that promotes myogenesis via Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells. PLoS ONE. 2020; 15 (4): e0231265. ( PubMed , DOI )

  7. Koga, H.; Negishi, M.; Kinoshita, M.; Fujii, S.; Mori, S.; Ishigami-Yuasa, M.; Kawachi, E.; Kagechika, H.; Tanatani, A.: Development of Androgen-Antagonistic Coumarinamides with a Unique Aromatic Folded Pharmacophore Int. J. Mol. Sci.. 2020; 21 (15): 5584. ( PubMed , DOI )

  8. Urushibara, K.; Yamada, T.; Yokoyama, A.; Mori, H.; Masu, H.; Azumaya, I.; Kagechika, H.; Yokozawa, T.; Tanatani, A.: Development of Helical Aromatic Amide Foldamers with a Diphenylacetylene Backbone J. Org. Chem.. 2020; 85 (4): 2019-2039. ( PubMed , DOI )

  1. Park SW, Nhieu J, Persaud SD, Miller MC, Xia Y, Lin YW, Lin YL, Kagechika H, Mayo KH, Wei LN: Publisher Correction: A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1. Scientific reports. 2019.11; 9 (1): 17042. ( PubMed , DOI )

  2. Masuno Hiroyuki, Kazui Yuko, Tanatani Aya, Fujii Shinya, Kawachi Emiko, Ikura Teikichi, Ito Nobutoshi, Yamamoto Keiko, Kagechika Hiroyuki: Development of novel lithocholic acid derivatives as vitamin D receptor agonists BIOORGANIC & MEDICINAL CHEMISTRY. 2019.08; 27 (16): 3674-3681. ( PubMed , DOI )

  3. Ishigami-Yuasa, M.; Ekimoto, H.; Kagechika, H.: Class IIb HDAC inhibition enhances the inhibitory effect of Am80, a synthetic retinoid, in prostate cancer Biol. Pharm. Bull.. 2019.03; 42 (3): 448-452. ( PubMed , DOI )

  4. Yokoo, H.; Kagechika, H.; Ohsaki, A; Hirano T.: A Polarity-Sensitive Fluorescent Amino Acid and its Incorporation into Peptides for the Ratiometric Detection of Biomolecular Interactions ChemPlusChem. 2019; 84 1716-1719. ( DOI )

  5. Mori, S.; Tsuemoto, N.; Kasagawa, T.; Nakano, E.; Fujii, S.; Kagechika, H.: Development of Boron-Cluster-Based Progesterone Receptor Antagonists Bearing a Pentafluorosulfanyl (SF5) Chem. Pharm. Bull.. 2019; 67 (12): 1278-1283.

  6. Mori, S.; Iinuma, H.; Manaka, N.; Ishigami-Yuasa, M.; Murayama, T.; Nishijima, Y.; Sakurai, A.; Arai, R.; Kurebayashi, N.; Sakurai, T.; Kagechika, H.: Structural development of a type-1 ryanodine receptor (RyR1) Ca2+-release channel inhibitor guided by endoplasmic reticulum Ca2+ assay Eur. J. Med. Chem.. 2019; 179 837-848. ( PubMed , DOI )

  7. Endo, Y.; Sugiura, Y.; Funasaki, M.; Kagechika, H.; Ishibashi, M.; Ohsaki, A.: Two new alkaloids from Crinum asiaticum var. japonicum. J. Nat. Med.. 2019; 73 (3): 648-652. ( PubMed , DOI )

  8. Kaitoh, K.; Nakatsu, A.; Mori, S.; Kagechika, H.; Hashimoto, Y.; Fujii, S.: Design, synthesis and biological evaluation of novel nonsteroidal progesterone receptor antagonists based on phenylamino-1,3,5-tirazine scaffold Chem. Pharm. Bull.. 2019; 67 (6): 566-575. ( PubMed , DOI )

  9. Park, S. W.; Nhieu, J.; Persaud, S. D.; Miller, M. C.; Xia, Y.; Lin, Y.-W.; Lin, Y.-L.; Kagechika, H.; Mayo, K. H.; Wei, L.-N.: A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1 Sci. Rep.. 2019; 9 10929. ( DOI )

  10. McDonald, M. G.; Yeung, C. K.; Teitelbaum, A. M.; Johnson, A. L.; Fujii, S.; Kagechika, H.; A New LC-MS Assay for the Quantitative Analysis of Vitamin K Metabolites in Human Urine Rettie, A. E.: A New LC-MS Assay for the Quantitative Analysis of Vitamin K Metabolites in Human Urine J. Lipid Res.. 2019; 60 (4): 892-899. ( DOI )

  11. Kanda, M.; Urushibara, Ko.; Park, S.; Fujii, S.; Masu, H.; Katagiri, K.; Azumaya, I.; Kagechika, H.; Tanatani, A.: Spontaneous Chiral Resolution of N,N’-Diarylsquaramides : Formation of Various Types of One-handed Helical Networks During Crystallization Tetrahedron . 2019; 75 (19): 2771-2777. ( DOI )

  12. Fujii, S.; Yanagida, N.; Mori, S.; Kawachi, E.; Kagechika, H: Design and synthesis of cyclohexyl-p-carborane derivatives as a new class of progesterone receptor antagonists Heterocycles . 2019; 99 (1): 425-445. ( DOI )

  13. Mori S, Tsuemoto N, Kasagawa T, Nakano E, Fujii S, Kagechika H: Development of Boron-Cluster-Based Progesterone Receptor Antagonists Bearing a Pentafluorosulfanyl (SF5) Group. Chemical & pharmaceutical bulletin. 2019; 67 (12): 1278-1283. ( PubMed , DOI )

  1. Urushibara, K.; Masu, H.; Mori, H.; Azumaya, I.; Hirano, T.; Kagechika,H.; Tanatani, A. : Synthesis and Conformational Analysis of Alternately N-Alkylated Aromatic Amide Oligomers J. Org. Chem.. 2018.11; 83 (23): 14338-14349. ( PubMed , DOI )

  2. Kazui, Y.; Fujii, S.; Yamada, A.; Ishigami-Yuasa, M.; Kagechika, H.; Tanatani, A.: Structure-Activity Relationship of Novel Androgen Receptor Antagonists Bearing a (Benzoylaminophenoxy)phenol Pharmacophore. Bioorg. Med. Chem.. 2018.10; 26 (18): 5118-5127. ( PubMed , DOI )

  3. Timalsina, S.; Arimoto-Matsuzaki, K.; Kitamura, M.; Xu, X.; Wenzhe, Q.; Ishigami-Yuasa, M.; Kagechika, H.; Hata, Y.: Chemical compounds that suppress hypoxia-induced stress granule formation enhance cancer drug sensitivity of human cervical cancer HeLa cells. J. Biochem.. 2018.10; 164 (5): 381-391. ( PubMed , DOI )

  4. Loppi, S.; Kolosowska, N.; Kärkkäinen, O.; Korhonen, P.; Huuskonen, M.; Grubman, A.; Dhungana, H.; Wojciechowski, S.; Pomeshchik, Y.; Giordano, M.; Kagechika, H.; White, A.; Auriola, S.; Koistinaho, J.; Landreth, G.; Hanhineva, K.; Kanninen, K.; Malm, T.: HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, preventsischemia-induced neuronal damag Brain Behav. Immunol.. 2018.09; 73 670-681. ( DOI )

  5. Li, M.; Qin, X.-Y.; Furutani, Y.; Inoue, I.; Sekihara, S.; Kagechika, H.; Kojima S.: Prevention of acute liver injury by suppressing plasma kallikrein-dependent activation of latent TGF-β Biochem. Biophys. Res. Chem.. 2018.09; 504 (4): 857-864. ( PubMed , DOI )

  6. Hirano, T.; Fujiwara, T.; Niwa, H.; Hirano, M.; Ohira, K.; Okazaki, Y.; Sato, S.; Umehara, T.; Maemoto, Y.; Ito, A.; Yoshida, M.; Kagechika, H.: Development of novel inhibitors for histone methyltransferase SET7/9 based on cyproheptadine ChemMedChem. 2018.08; 13 (15): 1530-1540. ( PubMed , DOI )

  7. Fujii, S.; Mori, S.; Kagechika, H.; Parra, M. A. M.; Gronemeyer, H.: Development of biotin-retinoid conjugates as chemical probes for analysis of retinoid function. Bioorg. Med. Chem. Lett.. 2018.07; 28 (14): 2442-2445. ( PubMed , DOI )

  8. Nishiyama, Y.; Mori, S.; Makishima, M.; Fujii, S.; Kagechika, H.; Hashimoto, Y.; Ishikawa, M.: Novel non-steroidal progesterone receptor (PR) antagonists with a phenanthridinone skeleton. ACS Med. Chem. Lett.. 2018.07; 9 (7): 641-645. ( PubMed , DOI )

  9. Qin, X.-Y.; Suzuki, H.; Honda, M.; Okada, H.; Kaneko, S.; Inoue, I.; Ebisui, E.; Hashimoto, K.; Carninci, P.; Kanki, K.; Tatsukawa, H.; Ishibashi, N.; Masaki, T.; Matsuura, T.; Kagechika, H.; Toriguchi, K.; Hatano, E.; Shirakami, Y.; Shiota, G.; Shimizu, M.; Moriwaki, H.; Kojima, S. : Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid. Proc. Nat. Acad. Sci. USA. 2018.06; 115 (19): 4969-4974. ( PubMed , DOI )

  10. Murayama, T.; Kurebayashi, Ishigami-Yuasa, M.; Mori, A.; Suzuki, Y.; Akima, R.; Ogawa, H.; Suzuki, J.; Kanemaru, K.; Oyamada, H.; Kiuchi, Y.; Iino, K.; Kagechika, H.; Sakurai, T. : Efficient High-Throughput Screening by Endoplasmic Reticulum Ca2+ Measurement to Identify Inhibitors of Ryanodine Receptor Ca2+-Release Channels Mol. Pharmacol. . 2018.06; 94 (1): 722-730. ( PubMed , DOI )

  11. Shu Shimada, Yoshimitsu Akiyama, Kaoru Mogushi, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiromi Nagasaki, Hiroshi Fukamachi, Yasuhito Yuasa, Shinji Tanaka: Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models. Br. J. Cancer. 2018.04; 118 (7): 972-984. ( PubMed , DOI )

  12. Tojo, Y.; Urushibara, K.; Yamamoto, S.; Mori, H.; Masu, H.; Kudo, M.; Hirano, T.; Azumaya, I.; Kagechika, H.; Tanatani, A.: Conformational Properties of Aromatic Oligoamides Bearing Pyrrole Rings. J. Org. Chem.. 2018.04; 83 (8): 4606-4617. ( PubMed , DOI )

  13. Park, S.; Uchida, J.; Urushibara, K.; Kagechika, H.; Kato, T.; Tanatani, A.: Self-assembly of Liquid-crystalline Squaramides. Chem. Lett.. 2018.04; 47 (4): 601-604. ( DOI )

  14. Urushitani, H.; Katsu, Y.; Kagechika, H.; Sousa, A. C. A.; Barroso, C. M.; Ohta, Y.; Shiraishi, H.; Iguchi, T.; Horiguchi, T.: Characterization and comparison of transcriptional activities of the retinoid X receptors by various organotin compounds in three prosobranch gastropods; Thais clavigera, Nucella lapillus and Babylonia japonica. Aquatic Toxicol. . 2018.04; 199 103-115. ( PubMed , DOI )

  15. Ando F, Mori S, Yui N, Morimoto T, Nomura N, Sohara E, Rai T, Sasaki S, Kondo Y, Kagechika H, Uchida S: AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus Nat Commun. 2018.04; 9 (1): 1411. ( PubMed , DOI )

  16. Yokoo, H.; Ohsaki, A.; Kagechika, H.; Hirano, T.: Unique properties of 1,5-naphthyridin-2(1H)-one derivatives as environmental-polarity-sensitive fluorescent dyes. Eur. J. Org. Chem.. 2018.03; 2018 (5): 679-687. ( DOI )

  17. Junichi Maruyama, Kazutoshi Inami, Fumiyoshi Michishita, Xinliang Jiang, Hiroaki Iwasa, Kentaro Nakagawa, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Norio Miyamura, Jun Hirayama, Hiroshi Nishina, Daichi Nogawa, Kouhei Yamamoto, Yutaka Hata: Novel YAP1 Activator, Identified by Transcription-Based Functional Screen, Limits Multiple Myeloma Growth. Mol. Cancer Res.. 2018.02; 16 (2): 197-211. ( PubMed , DOI )

  1. Mori, S.; Takagaki, R.; Fujii, S.; Urushibara, K.; Tanatani, A.; Kagechika, H.: Novel non-steroidal progesterone receptor ligands based on m-carborane containing a secondary alcohol: effect of chirality on ligand activity Chem. Pharm. Bull.. 2017.11; 65 (11): 1051-1057. ( PubMed , DOI )

  2. Endo,Y.; Kasahara,T.; Harada,K.; Kubo, M.; Etoh, T.; Ishibashi, M.; Ishiyama, A.; Iwatsuki, M.; Otoguro, K.; Ohmura, S.; Akisue, G.; Hirano, T.; Kagechika, H.; Fukuyama, Y.; Ohsaki, A.: Sucupiranins A−L, Furanocassane Diterpenoids from the Seeds of Bowdichia virgilioides. J. Nat. Prod. . 2017.11; 80 (12): 3120-3127. ( PubMed , DOI )

  3. Hoang, H. N.; Granero-Fernandez, E.; Yamada, S.; Mori, S.; Kagechika, H.; Medina-Gonzalez, Y.; Matsuda, T.: Modulating Biocatalytic Activity toward Sterically Bulky Substrates in CO2-Expanded Biobased Liquids by Tuning the Physicochemical Properties. ACS Sus. Chem. Eng.. 2017.10; 5 (11): 11051-11059. ( DOI )

  4. Yamasaki, R.; Iida, M.; Ito, A.; Fukuda, K.; Tanatani, A.; Kagechika, H., Masu, H. Okamoto, I. : Crystal Engineering of N,N’-Diphenylurea Compounds Featuring Phenyl-Perfluorophenyl Interaction Crystal Growth Des.. 2017.09; 17 5858-5866.

  5. Suzuki, D.; Saito-Hakoda, A.; Ito, R.; Shimizu, K.; Parvin, R.; Shimada, H.; Noro, E.; Suzuki, S.; Fujiwara, I.; Kagechika, H.; Rainey, W. E.; Kure, S.; Ito, S.; Yokoyama, A.; Sugawara, A. : Suppressive effects of RXR agonist PA024 on adrenal CYP11B2 expression, aldosterone secretion and blood pressure Plos ONE. 2017.08; 12 (8): e0181055. ( PubMed , DOI )

  6. Mori, S.; Hirano T.; Takaguchi, A.; Fujiwara, T.; Okazaki, Y.; Kagechika, H.: Selective Reagent for Detection of N-ε-Monomethylation of a Peptide Lysine Residue through SNAr Reaction European Journal of Organic Chemistry. 2017.07; 3606-3611.

  7. Yoshioka, H.; Yamada, A.; Nishiyama, Y.; Kagechika, H.; Hashimoto, Y.; Fujii, S.: Development of nonsteroidal glucocorticoid receptor modulators based on N-benzyl-N-(4-phenoxyphenyl)benzenesulfonamide scaffold Bioorganic and Medicinal Chemistry. 2017.07; 25 (13): 3461-3470.

  8. Yoshizaki, Y.; Mori, T.; Ishigami-Yuasa, M.; Kikuchi, E.; Takahashi, D.; Zeniya, M.; Nomura, N.; Mori, Y.; Araki, Y.; Ando, F.; Mandai, S.; Kasagi, Y.; Arai, Y.; Sasaki, E.; Yoshida, S.; Kagechika, H.; Rai, T.; Uchida, S.; Sohara, E.: Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation Spectroscopy Science Reports. 2017.07; 7 3945.

  9. Ishigami-Yuasa, M.; Watanabe, Y.; Mori, T.; Masuno, H.; Fujii, S.; Kikuchi, E.; Uchida, S.; Kagechika, H.: Development of WNK signaling inhibitors as a new class of antihypertensive drugs Bioorganic and Medicinal Chemistry. 2017.06; 25 (14): 3845-3852.

  10. Nguyen, B. N.; Okuno, Y.; Ajiro, M.; Iida, K.; Denawa, M.; Yamamoto, M.; Sakamoto, N.; Kagechika, H.; Hagiwara, M.: Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression Journal of Medical Virology. 2017.05; 89 (7): 1224-1234.

  11. Hoang, H. N.; Nagashima, Y.; Mori, S.; Kagechika, H.; Matsuda, T.: CO2-expanded bio-based liquids as novel solvents for enantioselective biocatalysis Tetrahedron . 2017.05; 73 (20): 2984-2989.

  12. Perri, M.; Caroleo, Nannan M. C.; Gallelli, L. L.; De Sarro, G.; Kagechika, H.; Cione, E.: 9-cis Retinoic acid modulates myotrophin expression and its miR in physiological and pathophysiological cell models Experimental Cell Research. 2017.04; 354 25-30.

  13. Tsuji, M.; Shudo, K.; Kagechika, H.: The receptor subtype selectivity of retinoid X and retinoic acid re-ceptors via quantum mechanics FEBS Open Bio. 2017.03; 7 391-396.

  14. Oya, Y.; Mondal, A.; Rawangkan, A.; Umsumarng, S.; Iida, K.; Watanabe, T.; Kanno, M.; Suzuki, K.; Li, Z.; Kagechika, H.; Shudo, K.; Fujiki, H.; Suganuma, M.: Down-regulation of histone deacetylase 4, −5 and −6 as a mechanism of synergistic enhancement of apoptosis in human lung cancer cells treated with the combination of a synthetic retinoid, Am80 and green tea catechin Journol of Nutritional Biochemistry. 2017.01; 42 7-16.

  1. Okamoto-Uchida, Y.; Yu, R.; Miyamura, N.; Arima, N.; Ishigami-Yuasa, M.; Kagechika, H.; Yoshida, S.; Hosoya, T.; Nawa, M.; Kasama, T.; Asaoka, Y.; Alois, R. W.; Elling, U.; Penninger, J. M.; Nishina, S.; Azuma, N.; Nishina, H.: The mevalonate pathway regulates primitive streak formation via protein farnesylation Science Reports. 2016.10; 6 37697.

  2. Kinoshita, M.; Negishi, M.; Sakai, H.; Hirano, T.; Mori, S.; Fujii, S.; Kagechika, H.; Tanatani, A.: Development of 6-Arylcoumarins as Nonsteroidal Progesterone Antagonists. Structure-activity Relationships and Fluorescence Properties Bioorganic & Medicinal Chemistry. 2016.09; 24 (21): 5602-5610.

  3. Yamada, A.; Kazui, Y.; Yoshioka, H.; Tanatani, A.; Mori, S.; Kagechika, H.; Fujii, S. : Development of N-(4-Phenoxyphenyl)benzenesulfonamide Derivatives as Novel Nonsteroidal Progesterone Receptor Antagonists ACS Medicinal Chemistry Letters. 2016.09; 7 (12): 1028-1033.

  4. Yokoo, H.; Ohsaki, A.; Kagechika, H.; Hirano T.: Structural development of canthin-5,6-dione moiety as a fluorescent dye and its application to novel fluorescent sensors Tetrahedron . 2016.08; 72 5872-5879.

  5. Fujiwara, T.; Ohira, K.; Urushibara, K.; Ito, A.; Yoshida, M.; Kanai, M.; Tanatani, A.; Kagechika, H.; Hirano, T.: Steric structure–activity relationship of cyproheptadine derivatives as inhibitors of histone methyltransferase Set7/9 Bioorganic & Medicinal Chemistry. 2016.07; 24 4318-4323.

  6. Hirano, T.; Noji, Y.; Shiraishi, T.; Ishigami-Yuasa, M.; Kagechika, H.: Development of an “OFF-ON-OFF” fluorescent pH sensor suitable for the study of intracellular pH Tetrahedron . 2016.06; 72 4925-4930.

  7. Nagashima, S.; Maruyama, J.; Kawano, S.; Iwasa, H.; Nakagawa, K.; Ishigami-Yuasa, M.; Kagechika, H.; Nishina, H.; Hata, Y.: Validation of the chemical compound library screening for TAZ inhibitors by use of green fluorescence protein-fused TAZ Cancer Science. 2016.06; 107 (6): 791-802.

  8. Takemoto, Y.; Ito, A.; Niwa, H.; Okamura, M.; Fujiwara, T.; Hirano, T.; Handa, N.; Umehara, T.; Sonoda, T.; Ogawa, K.; Tariq, M.; Nishino, N.; Dan, S.; Kagechika, H.; Yamori, T.; Yokoyama, S.; Yoshida, M.: Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription Journol of Medicinal Chemistry. 2016.04; 59 (8): 3650-3660.

  9. Persaud, S. D.; Park, S. W.; Ishigami-Yuasa, M.; Koyano-Nakagawa, N.;, Kagechika, H.; Wei, L.-N.: All trans-retinoic acid analogs promote cancer cell apoptosis through non-genomic Crabp1 mediating ERK1/2 phosphorylation Science Reports. 2016.03; 6 22396.

  10. Tsukada, H.; Kawabe, H.; Ohtaka, A.; Saito, Y.: Okamoto, Y.: Tori, M.; Kagechika, H.; Hirota, H.; Gong, X.; Kuroda, C.; Ohsaki, A.: Two new diterpenoids from Salvia przewarskii Natural Product Communications. 2016.01; 11 (2): 159-161.

  1. Shrestha, R.; Tatsukawa, H.; Shrestha, R.; Ishibashi, N.; Matsuura, T.; Kagechika, H.; Kose, S.; Hitomi, K.; Imamoto, N.; Kojima, S.: Molecular mechanism by which acyclic retinoid induces nuclear localization of transglutaminase 2 in human hepatocellular carcinoma cells. Cell Death & Disease. 2015.12; 6 e2002. ( DOI )

  2. Saito-Hakoda, A.; Uruno, A.; Yokoyama, A.; Shimizu, K.; Parvin, R.; Kudo, M.; Saito-Ito, T.; Sato, I.; Kogure, N.; Suzuki, D.; Shimada, H.; Yoshikawa, T .; Fujiwara, I.; Kagechika, H.; Iwasaki, Y.; Kure, S.; Ito, S.; Sugawara, A.: Effects of RXR Agonists on Cell Proliferation/Apoptosis and ACTH Secretion/Pomc Expression Plos ONE. 2015.11; 10 e0141960. ( DOI )

  3. Yu. R.: Miyamura, N.; Okamoto-Uchida, Y.; Arima, N.; Ishigami-Yuasa, M.; Kagechika, H.; Nishina, H.: A Modified Murine Embryonic Stem Cell Test for Evaluating the Teratogenic Effects of Drugs on Early Embryogenesis Plos ONE. 2015.11; 10 e0145286. ( DOI )

  4. Kikuchi E, Mori T, Zeniya M, Isobe K, Ishigami-Yuasa M, Fujii S, Kagechika H, Ishihara T, Mizushima T, Sasaki S, Sohara E, Rai T, Uchida S: Discovery of novel SPAK inhibitors that block WNK kinase signaling to cation chloride transporters. J Am Soc Nephrol. 2015.07; 26 (7): 1525-1536. ( PubMed , DOI )

  5. Nishiyama, S.; Urushibara, K.; Masu, H.; Azumaya, I.; Kagechika, H. Tanatani, A.: Conformational and chiral properties of cyclic-tri(N-methyl-meta-benzamide) bearing amidino groups Chirality. 2015; 27 487-491. ( DOI )

  6. Inoue, K.; Urushibara, K.; Kanai, M.; Yura, K.; Fujii, S.; Ishigami-Yuasa, M.; Hashimoto, Y.; Mori, S.; Kawachi, E.; Matsumura, M.; Hirano, T.; Kagechik, H.; Tanatani, A.: Design and synthesis of 4-benzyl-1-(2H)-phthalazinone derivatives as novel androgen receptor antagonists European Journal of Medicinal Chemistry. 2015; 102 310-319. ( DOI )

  7. Kodaka, M.; Yang, Z.; Nakagawa, K.; Maruyama, J.; Xu, X.; Sarkar, A.; Ichimura, A.; Nasu, Y.; Ozawa, T.; Iwasa, H.; Ishigami-Yuasa, M.; Ito, S.; Kagechika, H.; Hata, Y.: A new cell-based assay to evaluate myogenesis in mouse myoblast C2C12 cells Experimental Cell Research. 2015; 336 171-181. ( DOI )

  8. Qin, X.-Y.; Fujii, S.; Shimizu, A.; Kagechika, H.; KOJIMA, S.: Carboxylic derivatives of vitamin K2 inhibit hepatocellular carcinoma cell growth through caspase/transglutaminase-related signaling pathways Journal of Nutritional Science and Vitaminology. 2015; 61 285-290.

  9. Fujii, S.; Shimizu, A.; Takeda, N.; Oguchi, K.; Katsurai, T.; Shirakawa, H.; Komai, M.; Kagechika, H.: Systematic synthesis and anti-inflammatory activity of ω-carboxylated menaquinone derivatives - Investigations on identified and putative vitamin K2 metabolites - Bioorganic Medicinal Chemistry. 2015; 23 2344-2352.

  10. Shiraishi, T.; Kagechika, H.; Hirano, T.: 6-Arylcoumarins: versatile scaffolds for fluorescent sensors New Journal of Chemistry. 2015; 39 8389-8396. ( DOI )

  11. Tsuji, M.; Shudo, K.; Kagechika, H.: Docking simulations suggest that all-trans retinoic acid could bind to retinoid X receptors Journal of Computer Aided Molecular Design. 2015; 29 975-988. ( DOI )

  12. Kawano, S.; Maruyama, J.; Nagashima, S.; Inami, K.; Qiu, W.; Iwasa, H.; Nakagawa, K.; Ishigami-Yuasa, M.; Kagechika, H.; Nishina, H.; Hata, Y.: A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells The Journal of Biochemistry. 2015; 158 413-420. ( DOI )

  13. Brun, P.-J., Grijalva, A., Rausch, R., Watson, E., Yuen, J. J., Das, B. C., Shudo, K., Kagechika, H., Leibel, R. L., Blaner, W. S.: Retinoic acid receptor signaling is required to maintain glucose-stimulated insulin secretion and β-cell mass FASEB Journal. 2015; 26 671-683. ( DOI )

  14. Mori, S., Takeuchi, Y., Tanatani, A., Kagechika, H., Fujii, S.: Development of 1,3-diphenyladamantane derivatives as nonsteroidal progesterone receptor antagonists Bioorganic Medicinal Chemistry. 2015; 23 803-809. ( DOI )

  1. Fujii, S.; Kano, A.; Songkram, C.; Masuno, H.; Taoda, Y.; Kawachi, E.; Hirano, T.; Tanatani, A.; Kagechika, H.: Synthesis and structure-activity relationship of p-carborane-based non-secosteroidal vitamin D analogs. Bioorganic Medicinal Chemistry. 2014; 22 1227-1235. ( DOI )

  2. Uruno, A.; Saito-Hakoda, A.; Yokoyama, A.; Kogure, N.; Matsuda, K.; Parvin, R.; Shimizu, K.; Sato, I.; Kudo, M.; Yoshikawa, T.; Kagechika, H.; Iwasaki, Y.; Ito, S.; Sugawara, A.: Retinoic acid receptor-α up-regulates proopiomelanocortin gene expression in AtT20 corticotroph cells. Endocrine Journol. 2014; 61 1105-1114. ( DOI )

  3. Fujii, S.; Sekine, R.; Kano, A.; Masuno, H.; Songkram, C.; Kawachi, E.; Hirano, T.; Tanatani, A.; Kagechika, H.: Structural development of p-carborane-based potent non-secosteroidal vitamin D analogs Bioorganic Medicinal Chemistry. 2014; 22 5891-5901. ( DOI )

  4. Fujii, S.; Nakano, E.; Yanagid, N.; Mori, S.; Masuno, H.; Kagechika, H.: Development of p-carborane-based nonsteroidal progesterone receptor antagonists Bioorganic Medicinal Chemistry. 2014; 22 5329-5337. ( DOI )

  5. Fujii, S.; Yamada, A.; Nakano, E.; Takeuchi, Y.; Mori, S.; Masuno, H.; Kagechika, H.: Design and synthesis of nonsteroidal progesterone receptor antagonists based on C,C’-diphenylcarborane scaffold as a hydrophobic pharmacophore Europian Journol of Medicinal Chemistry. 2014; 84 264-277. ( DOI )

  6. Fujii, S.; Kano, A.; Masuno, H.; Songkram, C.; Kawachi, E.; Hirano, T.; Tanatani, A.; Kagechika, H.: Design and synthesis of tetraol derivatives of　 1,12-dicarba-closo-dodecaborane as non-secosteroidal vitamin D analogs Bioorganic Medicinal Chemistry Letters. 2014; 24 4515-4519. ( DOI )

  7. Yang, Z. Y.; Nakagawa, K.; Sarkar, A.; Maruyama, J.; Iwasa, H.; Bao, Y. J.; Ishigami-Yuasa, M.; Ito, S.; Kagechika, H.; Hata, S.; Nishina, H.; Abe, S.; Kitagawa, M.; Hata, Y.: Screening with a Novel Cell-Based Assay for TAZ Activators Identifies a Compound That Enhances Myogenesis in C2C12 Cells and Facilitates Muscle Repair in a Muscle Injury Model Molecular Cellular Biology. 2014; 34 1607-1621.

  8. Fujii, S.; Kobayashi, T.; Nakatsu, A.; Miyazawa, H.; Kagechika, H.: Synthesis and Structure–Activity Relationship Study of Triazine-Based Inhibitors of the DNA Binding of NF-κB Chemical Pharmaceutical Bulletin. 2014; 62 700-708. ( DOI )

  9. Ma, F.; Liu, S.-Y.; Razani, B.; Arora, N.; Li, B.; Kagechika, H.; Tontonoz, P.; Nunez, V.; Ricote, M.; Cheng, G.: Retinoid X receptor a attenuates host antiviral response by suppressing type I interferon Nature Communication. 2014; 5 5494. ( DOI )

  10. Mori, S.; Takagaki, R.; Fujii, S.; Matsumura, M.; Tanatani, A.; Kagechika, H.: Lipase-catalyzed asymmetric acylation of boron cluster-containing secondary alcohols Tetrahedron Asymmetry. 2014; 25 1505-1512. ( DOI )

  11. Canavan, M.; McCarthy, C.; Ben Larbi, N.; Dowling, J. K.; Collins, L.; O'Sullivan, F.; Hurley, G.; Murphy, C.; Quinlan, A.; Moloney, G.; Darby, T.; MacSharry, J.; Kagechika, H.; Moynagh, P.; Melgar, S.; Loscher, C. E.: Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-kappa Bp50 Innate Immunology. 2014; 20 675-687. ( DOI )

  12. Shiraishi, T.; Saito, T.; Kagechika, H.; Hirano, T.: Development of a novel fluorescent sensor to detect a specific range of pH Tetrahedron Letters. 2014; 55 6784-6786. ( DOI )

  13. Shinya Fujii, Aya Tanatani, Tomoya Hirano, Hiroyuki Kagechika: Development of nonsecosteroidal vitamin D derivatives bearing carborane as hydrophobic pharmacophore 2014; 88 389-395.

  14. Minoru Imai, Hiroyuki Kagechika: Develpmnt of anticancer drugs targeting retinoid nuclear receptors 2014; 249 1189-1193.

  15. Mari Yuasa, Hiroyuki Kagechika: Tecknology in Chemical Biology Research 2014; 53 407-410.

  16. Hiroyuki Kagechika: medicinal chemistry of nuclear receptors 2014; 32 299-305.

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