Kobayakawa T, Tsuji K, Tamamura H: Design, synthesis and evaluation of bioactivity of peptidomimetics based on chloroalkene dipeptide isosteres. Bioorganic & medicinal chemistry. 2024.08; 110 117811. ( PubMed , DOI )

Tsuji K, Tamamura H, Burke TR Jr: Affinity enhancement of polo-like kinase 1 polo box domain-binding ligands by a bivalent approach using a covalent kinase-binding component. RSC chemical biology. 2024.07; 5 (8): 721-728. ( PubMed , DOI )

Yamada S, Yamada K, Sugawara-Narutaki A, Baba Y, Yukawa H: Near-infrared-II fluorescence/magnetic resonance double modal imaging of transplanted stem cells using lanthanide co-doped gadolinium oxide nanoparticles. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2024.06; 40 (6): 1043-1050. ( PubMed , DOI )

Ishii T, Kobayakawa T, Matsuda K, Nigorikawa K, Bolah P, Noborio A, Tsuji K, Ohashi N, Yoshimura K, Nomura W, Mitsuya H, Maeda K, Tamamura H: Discovery of Potent DAG-Lactone Derivatives as HIV Latency Reversing Agents. ACS infectious diseases. 2024.05; 10 (6): 2250-2261. ( PubMed , DOI )

Kobayakawa Takuya, Yokoyama Masaru, Tsuji Kohei, Boku Sayaka, Kurakami Masaki, Fujino Masayuki, Ishii Takahiro, Miura Yutaro, Nishimura Soshi, Shinohara Kouki, Yamamoto Kenichi, Bolah Peter, Kotani Osamu, Murakami Tsutomu, Sato Hironori, Tamamura Hirokazu: Development of Small-Molecule Anti-HIV-1 Agents Targeting HIV-1 Capsid Proteins(タイトル和訳中) Chemical & Pharmaceutical Bulletin. 2024.01; 72 (1): 41-47. ( 医中誌 )

Kobayakawa T, Yokoyama M, Tsuji K, Boku S, Kurakami M, Fujino M, Ishii T, Miura Y, Nishimura S, Shinohara K, Yamamoto K, Bolah P, Kotani O, Murakami T, Sato H, Tamamura H: Development of Small-Molecule Anti-HIV-1 Agents Targeting HIV-1 Capsid Proteins. Chemical & pharmaceutical bulletin. 2024; 72 (1): 41-47. ( PubMed , DOI )

Tsuji K, Tamamura H, Burke TR Jr: Application of a Fluorescence Recovery-Based Polo-Like Kinase 1 Binding Assay to Polo-Like Kinase 2 and Polo-Like Kinase 3. Biological & pharmaceutical bulletin. 2024; 47 (7): 1282-1287. ( PubMed , DOI )

Kobayakawa T, Takano H, Ishii T, Bolah P, Tsuji K, Ohashi N, Nomura W, Furuta T, Tamamura H: Effect of Two-Photon Excitation to 8-Azacoumarin Derivatives as Photolabile Protecting Groups. Chemical & pharmaceutical bulletin. 2024; 72 (3): 311-312. ( PubMed , DOI )

Kohei Tsuji, Takuya Kobayakawa, Takahiro Ishii, Nobuyo Higashi-Kuwata, Chika Azuma, Kouki Shinohara, Yutaro Miura, Kenichi Yamamoto, Soshi Nishimura, Shin-ichiro Hattori, Haydar Bulut, Hiroaki Mitsuya, Hirokazu Tamamura: Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement. Chemical and Pharmaceutical Bulletin. 2023.12; 71 (12): 879-886. ( PubMed , DOI )

Tsuji Kohei, Kobayakawa Takuya, Ishii Takahiro, Higashi-Kuwata Nobuyo, Azuma Chika, Shinohara Kouki, Miura Yutaro, Yamamoto Kenichi, Nishimura Soshi, Hattori Shin-ichiro, Bulut Haydar, Mitsuya Hiroaki, Tamamura Hirokazu: Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement(タイトル和訳中) Chemical & Pharmaceutical Bulletin. 2023.12; 71 (12): 879-886. ( 医中誌 )

Aoki K, Sugawara-Narutaki A, Takahashi R: Polymeric Sol-Gel Transition with the Diverging Correlation Length Verified by Small-Angle X-ray Scattering. The journal of physical chemistry letters. 2023.11; 14 (46): 10396-10401. ( PubMed , DOI )

Tsuji K, Ishii T, Kobayakawa T, Higashi-Kuwata N, Shinohara K, Azuma C, Miura Y, Nakano H, Wada N, Hattori SI, Bulut H, Mitsuya H, Tamamura H: Structure-Activity Relationship Studies of SARS-CoV-2 Main Protease Inhibitors Containing 4-Fluorobenzothiazole-2-carbonyl Moieties. Journal of medicinal chemistry. 2023.09; 66 (19): 13516-13529. ( PubMed , DOI )

Takahiro Ishii, Takuya Kobayakawa, Kouki Matsuda, Kohei Tsuji, Nami Ohashi, Shingo Nakahata, Airi Noborio, Kazuhisa Yoshimura, Hiroaki Mitsuya, Kenji Maeda, Hirokazu Tamamura: Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity. European Journal of Medicinal Chemistry. 2023.08; 256 115449. ( PubMed , DOI )

Nhieu, J.; Milbauer, L.; Lerdall, T.; Najjar, F.; Wei, C.-W.; Ishida, R.; Ma, Y.; Kagechika, H.; Wei, L.-N.: Targeting Cellular Retinoic Acid Binding Protein 1 with Retinoic Acid-like Compounds to Mitigate Motor Neuron Degeneration Int. J. Mol. Sci.. 2023.03; 24 4980.

Kohei Tsuji, Kofi Baffour-Awuah Owusu, Yutaro Miura, Takahiro Ishii, Kouki Shinohara, Takuya Kobayakawa, Akino Emi, Takashi Nakano, Youichi Suzuki, Hirokazu Tamamura : Dimerized fusion inhibitor peptides targeting the HR1–HR2 interaction of SARS-CoV-2 RSC Advances. 2023.03; 13 8779-8793.

Higashi-Kuwata N, Tsuji K, Hayashi H, Bulut H, Kiso M, Imai M, Ogata-Aoki H, Ishii T, Kobayakawa T, Nakano K, Takamune N, Kishimoto N, Hattori SI, Das D, Uemura Y, Shimizu Y, Aoki M, Hasegawa K, Suzuki S, Nishiyama A, Saruwatari J, Shimizu Y, Sukenaga Y, Takamatsu Y, Tsuchiya K, Maeda K, Yoshimura K, Iida S, Ozono S, Suzuki T, Okamura T, Misumi S, Kawaoka Y, Tamamura H, Mitsuya H: Identification of SARS-CoV-2 M(pro) inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2. Nature communications. 2023.02; 14 (1): 1076. ( PubMed , DOI )

Kitamura H., Sukegawa S., Matsuda K., Tanimoto K., Kobayakawa T., Takahashi K., Tamamura H., Tsuchiya K., Gatanaga H., Maeda K., and Takeuchi H.: 4-phenylquinoline-8-amine induces HIV-1 reactivation and apoptosis in latently HIV-1 infected cells. Biochemical and Biophysical Research Communications. 2023.01; 641 139-147. ( PubMed , DOI )

Yamada Shota, Yukawa Hiroshi, Kitamura Koudai, Mizumaki Toshiki, Yoshizumi Yasuma, Oohara Tomomi, Nanizawa Eri, Hirano Fumika, Sato Kazuhide, Sugawara-Narutaki Ayae, Ishikawa Tetsuya, Baba Yoshinobu: In Vivo Real-Time Quantum Dots Imaging to Track Transplanted Adipose Stem Cells in Different Inflammatory States of Acute Liver Failure Mice CELL TRANSPLANTATION. 2023; 32 9636897231176442. ( PubMed , DOI )

Tsuboi, Y.; Oyama, K.; Kobirumaki-Shimozawa, F.; Murayama, T.; Kurebayashi, N.; Tachibana, T.; Manome, Y.; Kikuchi, E.; Noguchi, S.; Inoue, T.; Inoue, Y. U.; Nishino, I.; Mori, S.; Ishida, R.; Kagechika, H.; Suzuki, M.; Fukuda, N.; Yamazawa, T.: Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes J. Gen. Physiol.. 2022.12; 154 e202213136.

Murayama, T.; Kurebayashi, N.; Numaga-Tomita, T.; Kobayashi, T.; Okazaki, S.; Yamashiro, K.; Nakada, T.; Mori, S.; Ishida, R.; Kagechika, H.; Yamada, M.; Sakurai, T.: A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery. J. Gen. Physiol.. 2022.12; 154 (12): e202213230. ( DOI )

Natsume K, Nakamura J, Sato K, Ohtsuki C, Sugawara-Narutaki A: Biological properties of self-assembled nanofibers of elastin-like block polypeptides for tissue-engineered vascular grafts: platelet inhibition, endothelial cell activation and smooth muscle cell maintenance. Regenerative biomaterials. 2022.12; 10 rbac111. ( PubMed , DOI )

Rongyi Wang, Kohei Tsuji, Takuya Kobayakawa, Yishan Liu, Kazuhisa Yoshimura, Shuzo Matsushita, Shigeyoshi Harada, Hirokazu Tamamura: Hybrids of small CD4 mimics and gp41-related peptides as dual-target HIV entry inhibitors Bioorganic & Medicinal Chemistry. 2022.12; 76 117083. ( PubMed , DOI )

Matsumoto K, Kuwata T, Tolbert WD, Richard J, Ding S, Prévost J, Takahama S, Judicate GP, Ueno T, Nakata H, Kobayakawa T, Tsuji K, Tamamura H, Smith AB 3rd, Pazgier M, Finzi A, Matsushita S: Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates. Journal of virology. 2022.12; 97 (1): e0163822. ( PubMed , DOI )

Matsuura K, Yamaura M, Sakawaki H, Himeno A, Pisil Y, Kobayakawa T, Tsuji K, Tamamura H, Matsushita S, Miura T: Sensitivity to a CD4 mimic of a consensus clone of monkey-adapted CCR5-tropic SHIV-MK38C. Virology. 2022.12; 578 171-179. ( PubMed , DOI )

Yamada, S.; Masuno, H.; Kagechika, H.; Tanatani, A.; Kanda, Y: A Novel Lithocholic Acid Derivative Upregulates Detoxification-Related Genes in Human Induced Pluripotent Stem Cell-Derived Intestinal Organoids. Biol. Pharm. Bull.. 2022.11; 45 (1720): 1724.

Tsuji K, Ishii T, Kobayakawa T, Higashi-Kuwata N, Azuma C, Nakayama M, Onishi T, Nakano H, Wada N, Hori M, Shinohara K, Miura Y, Kawada T, Hayashi H, Hattori SI, Bulut H, Das D, Takamune N, Kishimoto N, Saruwatari J, Okamura T, Nakano K, Misumi S, Mitsuya H, Tamamura H: Potent and biostable inhibitors of the main protease of SARS-CoV-2. iScience. 2022.11; 105365. ( PubMed , DOI )

Tsuji K, Ishii T, Kobayakawa T, Higashi-Kuwata N, Azuma C, Nakayama M, Onishi T, Nakano H, Wada N, Hori M, Shinohara K, Miura Y, Kawada T, Hayashi H, Hattori SI, Bulut H, Das D, Takamune N, Kishimoto N, Saruwatari J, Okamura T, Nakano K, Misumi S, Mitsuya H, Tamamura H: Potent and biostable inhibitors of the main protease of SARS-CoV-2. iScience. 2022.11; 105365. ( PubMed , DOI )

Ishida, R.; Mori, S.; Murayama, T.; Nakamichi, A.; Chai, X.; Kurebayashi, N. Iinuma, H.; Kagechika, H.: Development of a water-soluble ryanodine receptor 1 inhibitor. Bioorg. Med. Chem.. 2022.09; 74 117027. ( DOI )

Mori, S.; Tsuemoto, N.; Kawachi, E.; Takubo, C.; Tanatani, A.; Kagechika, H.: Development of retinoic acid receptor antagonists bearing trans-SF4-alkynyl structure as a linear linker. Tetrahedron . 2022.08; 123 132967. ( DOI )

Kohei Tsuji, David Hymel, Buyong Ma, Hirokazu Tamamura, Ruth Nussinov, Terrence R Burke Jr: Development of ultra-high affinity bivalent ligands targeting the polo-like kinase 1. RSC chemical biology. 2022.08; 3 (9): 1111-1120. ( PubMed , DOI )

Hara Y, Ando F, Oikawa D, Ichimura K, Yanagawa H, Sakamaki Y, Nanamatsu A, Fujiki T, Mori S, Suzuki S, Yui N, Mandai S, Susa K, Mori T, Sohara E, Rai T, Takahashi M, Sasaki S, Kagechika H, Tokunaga F, Uchida S: LRBA is essential for urinary concentration and body water homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 2022.07; 119 (30): e2202125119. ( PubMed , DOI )

Hara, Y.; Ando, F.; Oikawa, D.; Ichimura, K.; Yanagawa, H.; Sakamaki, Y.; Nanamatsu, A.; Fujiki, T.; Mori, S.; Suzuki, S.; Yui, N.; Mandai, S.; Susa, K.; Mori, T.; Sohara, E.; Rai, T.; Takahashi, M.; Sasaki, S.; Kagechika, H.; Tokunaga, F.; Uchida, S.: LRBA is essential for urinary concentration and body water homeostasis Proc. Natl. Acad. Sci. USA. 2022.07; 119 (30): e2202125119.

Structure and Rheology of Poly(vinylidene difluoride-co-hexafluoropropylene) in an Ionic Liquid: The Solvent Behaves as a Weak Cross-Linker through Ion–Dipole Interaction 2022.06; 55 (13): 5591-5600. ( DOI )

Oikawa, T.; Fujii, S.; Mori, S.; Masuno, H.; Kawachi, E.; Kagechika, H. : Structural Development of Silicon-Containing Retinoids: Structure–Activity Relationship Study of the Hydrophobic Pharmacophore of Retinobenzoic Acids Using Silyl Functionalities ChemMedChem. 2022.06; e202200176.

Tsuji K, Kobayakawa T, Konno K, Masuda A, Takahashi K, Ohashi N, Yoshimura K, Kuwata T, Matsushita S, Harada S, Tamamura H: Exploratory studies on soluble small molecule CD4 mimics as HIV entry inhibitors. Bioorganic & medicinal chemistry. 2022.01; 56 116616. ( PubMed , DOI )

Yoshihara, A.; Kawasaki, H.; Masuno, M.; Takada, K.; Numoto, N.; Ito, N.; Hirata, N.; Kanda, Y.; Ishizawa, M.; Makishima, M.; Kagechika, H.; Tanatani, A.: Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists Biomolecules. 2022.01; 12 (1): 130.

Yoshihara Ayana, Kawasaki Haru, Masuno Hiroyuki, Takada Koki, Numoto Nobutaka, Ito Nobutoshi, Hirata Naoya, Kanda Yasunari, Ishizawa Michiyasu, Makishima Makoto, Kagechika Hiroyuki, Tanatani Aya: Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists BIOMOLECULES. 2022.01; 12 (1): ( PubMed , DOI )

Taishi Yokoi, Akiyoshi Mio, Jin Nakamura, Ayae Sugawara-Narutaki, Masakazu Kawashita, Chikara Ohtsuki: Transformation behaviour of salts composed of calcium ions and phosphate esters with different linear alkyl chain structures in a simulated body fluid modified with alkaline phosphatase. Sci Technol Adv Mater. 2022; 23 (1): 341-351. ( PubMed , DOI )

Takayanagi, S.; Watanabe, K.; Maruyama, T.; Ogawa, M.; Morishita, K.; Soga, M.; Hatta, T.; Natsume, T.; Hirano, T.; Kagechika, H.; Hattori, K.; Naguro, I.; Ichijo, H.: ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes Sci. Rep.. 2021.10; 11 22009.

Kohei Tsuji, Takahiro Ishii, Takuya Kobayakawa, Nami Ohashi, Wataru Nomura & Hirokazu Tamamura: Fluorescence resonance energy transfer-based screening for protein kinase C ligands using 6-methoxynaphthalene-labeled 1,2-diacylglycerol-lactones. Organic & Biomolecular Chemistry. 2021.10; 19 (38): 8264-8271. ( PubMed , DOI )

Fujii, S.; Kikuchi, E.; Suzuyama, H.; Watanabe, Y.; Ishigami-Yuasa, M.; Masuno, H.; Mori, T.; Isobe, K.; Uchida, S.; Kagechika, H.: Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents ChemMedChem. 2021.09; 16 (18): 2817-2822.

David Hymel, Kohei Tsuji, Robert A Grant, Ramesh M Chingle, Dominique L Kunciw, Michael B Yaffe, Terrence R Burke Jr: Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain - binding peptide macrocycles. Organic & Biomolecular Chemistry. 2021.09; 19 (36): 7843-7854. ( PubMed , DOI )

Lin Liu, Hiroyuki Koike, Takehito Ono, Shinichiro Hayashi, Fujimi Kudo, Atsushi Kaneda, Hiroyuki Kagechika, Ichiro Manabe, Tomoki Nakashima, Yumiko Oishi: Identification of a KLF5-dependent program and drug development for skeletal muscle atrophy. Proc Natl Acad Sci U S A. 2021.08; 118 (35): ( PubMed , DOI )

Hasan Md Zahid, Takeo Kuwata, Shokichi Takahama, Yu Kaku, Shashwata Biswas, Kaho Matsumoto, Hirokazu Tamamura & Shuzo Matsushita: Functional Analysis of a Monoclonal Antibody Reactive against the C1C2 of Env Obtained from a Patient Infected with HIV-1 CRF02_AG. Retrovirology. 2021.08; 18 (1): 23(article number).

Fujii Shinya, Kikuchi Eriko, Suzuyama Honoka, Watanabe Yuko, Ishigami-Yuasa Mari, Masuno Hiroyuki, Mori Takayasu, Isobe Kiyoshi, Uchida Shinichi, Kagechika Hiroyuki: Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents CHEMMEDCHEM. 2021.07; 16 (18): 2817-2822. ( PubMed , DOI )

Konishi, M.; Noguchi, S.; Inoue, T.; Inoue, Y. U.; Nishino, I.; Mori, S.; Iinuma, H.; Manaka, N.; Kagechika, H.; Uryash, A.; Adams, J.; Lopez, J. R.; Liu, X. C.; Diggle, C.; Allen, P. D.; Kakizawa, S.; Ikeda, K.; Lin, B. Z.; Ikemi, Y.; Nunomura, K.; Nakagawa, S.; Sakurai, T.; Murayama, T.: A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke Nature Commun.. 2021.07; 12 (1): 4293. ( DOI )

Lin, Y.-W.; Nhieu, J.; Wei, C.-W.; Lin, Y.-L.; Kagechika, H.; Wei, L.-N.: Regulation of exosome secretion by cellular retinoic acid binding protein 1 contributes to systemic anti-inflammation Cell Commun. Signal.. 2021.06; 19 (1): 69. ( PubMed , DOI )

Jan Vincent V. Arafiles, Hisaaki Hirose, Yusuke Hirai, Masashi Kuriyama, Maxwell Mamfe Sakyiamah, Wataru Nomura, Kazuhiro Sonomura, Miki Imanishi, Akira Otaka, Hirokazu Tamamura & Shiroh Futaki: Discovery of a Macropinocytosis-inducing Peptide Potentiated by Medium-mediated Intramolecular Disulfide Formation. Angewandte Chemie International Edition. 2021.05; 60 (21): 11928-11936.

Nagashima S, Maruyama J, Honda K, Kondoh Y, Osada H, Nawa M, Nakahama KI, Ishigami-Yuasa M, Kagechika H, Sugimura H, Iwasa H, Arimoto-Matsuzaki K, Nishina H, Hata Y: CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells. The Journal of biological chemistry. 2021.05; 297 (1): 100803. ( PubMed , DOI )

Suzuki Seiya, Lee Sungho, Miyajima Tatsuya, Kato Katsuya, Sugawara-Narutaki Ayae, Sakurai Makoto, Nagata Fukue: Evaluation of Drug-Loading Ability of Poly(Lactic Acid)/Hydroxyapatite Core-Shell Particles MATERIALS. 2021.04; 14 (8): ( PubMed , DOI )

Kato, D.; Shiraishi, T.; Kagechika, H.; Hirano, T.: Design, synthesis and antitumor activity of phthalazine-1,4-dione-based menaquinone analogs Bioorg. Med. Chem. Lett.. 2021.04; 43 128065. ( PubMed , DOI )

Lee S, Miyajima T, Sugawara-Narutaki A, Kato K, Nagata F: Development of paclitaxel-loaded poly(lactic acid)/hydroxyapatite core-shell nanoparticles as a stimuli-responsive drug delivery system. Royal Society open science. 2021.03; 8 (3): 202030. ( PubMed , DOI )

Takuya Kobayakawa, Chika Azuma, Yuki Watanabe, Shunsuke Sawamura, Atsuhiko Taniguchi, Yoshio Hayashi, Kohei Tsuji & Hirokazu Tamamura: Development of Methods for Convergent Synthesis of Chloroalkene Dipeptide Isosteres and Its Application. The Journal of Organic Chemistry. 2021.03; 86 (7): 5091-5101. ( PubMed , DOI )

Takuya Kobayakawa, Masaru Yokoyama, Kohei Tsuji, Masayuki Fujino, Masaki Kurakami, Sayaka Boku, Miyuki Nakayama, Moemi Kaneko, Nami Ohashi, Osamu Kotani, Tsutomu Murakami, Hironori Sato & Hirokazu Tamamura: Small-Molecule Anti-HIV-1 Agents Based on HIV-1 Capsid Proteins. Biomolecules. 2021.02; 11 (2): 208. ( PubMed , DOI )

Kato Daiki, Shiraishi Takuya, Kagechika Hiroyuki, Hirano Tomoya: 6-Arylcoumarin as a Scaffold of Photofunctional Molecules with OFF-ON-OFF Type Regulation JOURNAL OF ORGANIC CHEMISTRY. 2021.02; 86 (3): 2264-2270. ( PubMed , DOI )

Cione, E.; Caroleo, M. C.; Kagechika, H.; Manetti, F.: Pharmacophore-guided repurposing of fibrates and retinoids as GPR40 allosteric ligands. J. Enzyme Inhibit. Med. Chem. 2021.02; 36 (1): 377-383. ( PubMed , DOI )

Takuya Kobayakawa, Kohei Tsuji, Kiju Konno, Ai Himeno, Ami Masuda, Tingting Yang, Kohei Takahashi, Yusuke Ishida, Nami Ohashi, Takeo Kuwata, Kaho Matsumoto, Kazuhisa Yoshimura, Hiromi Sakawaki, Tomoyuki Miura, Shigeyoshi Harada, Shuzo Matsushita & Hirokazu Tamamura: Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors. Journal of Medicinal Chemistry. 2021.01; 64 (3): 1481-1496. ( PubMed , DOI )

Kohei Tsuji, Rongyi Wang, Takuya Kobayakawa, Kofi Baffour-Awuah Owusu, Masayuki Fujino, Moemi Kaneko, Naoki Yamamoto, Tsutomu Murakami, Hirokazu Tamamura: Potent leads based on CA-19L, an anti-HIV active HIV-1 capsid fragment. Bioorganic & Medicinal Chemistry. 2021.01; 30 115923. ( PubMed , DOI )

Kouki Matsuda, Takuya Kobayakawa, Ryusho Kariya, Kiyoto Tsuchiya, Kohei Tsuji, Takahiro Ishii, Hiroyuki Gatanaga, Kazuhisa Yoshimura, Seiji Okada, Hiroaki Mitsuya, Hirokazu Tamamura & Kenji Maeda: A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells With a Combination of Latency-Reversing Agents Containing DAG-Lactone PKC Activators. Frontiers in Microbiology. 2021; 12 636276. ( PubMed , DOI )

Takuya Kobayakawa, Hirokazu Tamamura: Chloroalkene dipeptide isosteres as peptidomimetics. Methods in enzymology. 2021; 656 191-239. ( PubMed , DOI )

Nakamura J, Ito R, Kozaki R, Sugawara-Narutaki A, Ohtsuki C: Organic modification of layered zirconium phosphate/phosphonate for controlled release of therapeutic inorganic ions. Science and technology of advanced materials. 2021; 22 (1): 1000-1012. ( PubMed , DOI )

Fujii, S.; Sekine, R.; Kano, A.; Masuno, H.; Kawachi, E.; Hirano, T.; Kagechika, H.: Synthesis and Structure-Activity Relationship Study of 1,12-Dicarba-closo-dodecaborane-based Triol Derivatives as Nonsecosteroidal Vitamin D Analogs Heterocycles. 2021; 103 (1): 444-458. ( DOI )

Arimura, M.; Tanaka, K.; Kanda, M.; Urushibara, K.; Fujii, S.*; Katagiri, K.; Azumaya, I.; Kagechika, H.; Tanatani, A.: Construction of Aromatic Multilayered Structures Based on the Conformational Properties of N,N’-Dimethylated Squaramide ChemPlusChem. 2021; 86 (1): 198-205. ( PubMed , DOI )

Sasaki H, Masuno H, Kawasaki H, Yoshihara A, Numoto N, Ito N, Ishida H, Yamamoto K, Hirata N, Kanda Y, Kawachi E, Kagechika H, Tanatani A: Lithocholic Acid Derivatives as Potent Vitamin D Receptor Agonists. Journal of medicinal chemistry. 2020.12; 64 (1): 516-526. ( PubMed , DOI )

Takuya Kobayakawa, Kento Ebihara, Kohei Tsuji, Takuma Kawada, Masayuki Fujino, Yuzuna Honda, Nami Ohashi, Tsutomu Murakami, Hirokazu Tamamura: Bivalent HIV-1 fusion inhibitors based on peptidomimetics. Bioorg. Med. Chem. 2020.12; 28 (24): 115812. ( PubMed , DOI )

Sato Atsushi, Shimizu Masahiro, Goto Toshiyasu, Masuno Hiroyuki, Kagechika Hiroyuki, Tanaka Nobuyuki, Shibuya Hiroshi: WNK regulates Wnt signalling and beta-Catenin levels by interfering with the interaction between beta-Catenin and GID COMMUNICATIONS BIOLOGY. 2020.11; 3 (1): ( DOI )

Stephen E. Miller, Kohei Tsuji, Rachel P.M. Abrams, Terrence R. Burke, Jr., Joel P. Schneider: Uncoupling the Folding-Function Paradigm of Lytic Peptides to Deliver Impermeable Inhibitors of Intracellular Protein-Protein Interactions. J. Am. Chem. Soc. 2020.11; 142 (47): 19950-19955. ( PubMed , DOI )

Daisuke Matsumoto, Hirokazu Tamamura, Wataru Nomura: A cell cycle-dependent CRISPR-Cas9 activation system based on an anti-CRISPR protein shows improved genome editing accuracy Communications Biology. 2020.10; 3 1-10. ( PubMed , DOI )

Sakakitani S, Podyma-Inoue KA, Takayama R, Takahashi K, Ishigami-Yuasa M, Kagechika H, Harada H, Watabe T: Activation of β2-adrenergic receptor signals suppresses mesenchymal phenotypes of oral squamous cell carcinoma cells. Cancer Science. 2020.10; ( PubMed , DOI )

Kohei Tsuji, David Hymel, Terrence R. Burke, Jr.: A new genre of fluorescence recovery assay to evaluate polo-like kinase 1 ATP-competitive inhibitors. Anal. Methods: advancing methods and applications. 2020.09; 12 (36): 4418-4421. ( PubMed , DOI )

Fumio Asai, Takahiro Seki, Ayae Sugawara-Narutaki, Kazuhide Sato, Jérémy Odent, Olivier Coulembier, Jean-Marie Raquez, Yukikazu Takeoka: Tough and 3D-Printable Poly (2-methoxyethyl Acrylate)-Silica Composite Elastomer with Anti-Platelet Adhesion Property ACS Applied Materials & Interfaces. 2020.09; 12 (41): 46621-46628-46628. ( PubMed , DOI )

Fujii Shinya, Kikuchi Eriko, Watanabe Yuko, Suzuyama Honoka, Ishigami-Yuasa Mari, Mori Takayasu, Isobe Kiyoshi, Uchida Shinichi, Kagechika Hiroyuki: Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2020.09; 30 (17): 127408. ( PubMed , DOI )

Koichiro Hayashi, Atsuto Tokuda, Jin Nakamura, Ayae Sugawara-Narutaki, Chikara Ohtsuki: Tearable and Fillable Composite Sponges Capable of Heat Generation and Drug Release in Response to Alternating Magnetic Field Materials. 2020.08; 13 (16): 3637(12 pages). ( PubMed , DOI )

Junpeng Qi, Kohei Tsuji, David Hymel, Terrence R. Burke, Jr., Michael Hudecek, Christoph Rader, Haiyong Peng: Chemically Programmable and Switchable CAR-T Therapy Angew. Chem., Int. Ed. 2020.07; 59 (29): 12178-12185 . ( PubMed , DOI )

Kohei Tsuji, Kofi Baffour-Awuah Owusu, Takuya Kobayakawa, Rongyi Wang, Masayuki Fujino, Moemi Kaneko, Naoki Yamamoto, Tsutomu Murakami, Hirokazu Tamamura: Exploratory studies on CA-15L, an anti-HIV active HIV-1 capsid fragment. Bioorg. Med. Chem. 2020.06; 28 (11): 115488. ( PubMed , DOI )

Ayae Sugawara-Narutaki, Yukiko Kamiya: Designer Biopolymers: Self-Assembling Proteins and Nucleic Acids Int. J. Mol. Sci.. 2020.05; 21 (9): 3276(3 pages). ( PubMed , DOI )

Takuya Kobayakawa, Hikaru Takano, Takahiro Ishii, Kohei Tsuji, Nami Ohashi, Wataru Nomura, Toshiaki Furuta, Hirokazu Tamamura: Synthesis of hydrophilic caged DAG-lactones for chemical biology applications. Org. Biomol. Chem. 2020.05; 18 (22): 4217-4223 . ( PubMed , DOI )

Erika Ishihara, Yuya Nagaoka, Toshiaki Okuno, Satoshi Kofuji, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Kenya Kamimura, Shuji Terai, Takehiko Yokomizo, Yukihiko Sugimoto, Yasuyuki Fujita, Akira Suzuki, Hiroshi Nishina: Prostaglandin E2 and its receptor EP2 trigger signaling that contributes to YAP-mediated cell competition. Genes Cells. 2020.03; 25 (3): 197-214. ( PubMed , DOI )

Ayae Sugawara-Narutaki: Bioinspired Synthesis of Silica Nanocups -Polymer-Mediated Self-Assembly of Inorganic Nanoparticles Impact. 2020.02; 2020 (1): 38-40. ( DOI )

Daisuke Matsumoto, Hirokazu Tamamura, Wataru Nomura: TALEN-Based Chemically Inducible, Dimerization-Dependent, Sequence-Specific Nucleases Biochemistry . 2020.01; 59 (2): 197-204. ( PubMed , DOI )

Manami Kodaka, Fengju Mao, Kyoko Arimoto-Matsuzaki, Masami Kitamura, Xiaoyin Xu, Zeyu Yang, Kentaro Nakagawa, Junichi Maruyama, Kana Ishii, Chihiro Akazawa, Takuya Oyaizu, Naoki Yamamoto, Mari Ishigami-Yuasa, Nozomi Tsuemoto, Shigeru Ito, Hiroyuki Kagechika, Hiroshi Nishina, Yutaka Hata: Characterization of a novel compound that promotes myogenesis via Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells. PLoS ONE. 2020; 15 (4): e0231265. ( PubMed , DOI )

Koga, H.; Negishi, M.; Kinoshita, M.; Fujii, S.; Mori, S.; Ishigami-Yuasa, M.; Kawachi, E.; Kagechika, H.; Tanatani, A.: Development of Androgen-Antagonistic Coumarinamides with a Unique Aromatic Folded Pharmacophore Int. J. Mol. Sci.. 2020; 21 (15): 5584. ( PubMed , DOI )

Urushibara, K.; Yamada, T.; Yokoyama, A.; Mori, H.; Masu, H.; Azumaya, I.; Kagechika, H.; Yokozawa, T.; Tanatani, A.: Development of Helical Aromatic Amide Foldamers with a Diphenylacetylene Backbone J. Org. Chem.. 2020; 85 (4): 2019-2039. ( PubMed , DOI )

Ayae Sugawara-Narutaki, Sawako Yasunaga, Yusuke Sugioka, Duc H. T. Le, Issei Kitamura, Jin Nakamura, Chikara Ohtsuki: Rheology of Dispersions of High-Aspect-Ratio Nanofibers Assembled from Elastin-Like Double-Hydrophobic Polypeptides Int. J. Mol. Sci.. 2019.12; 20 (24): 6262. ( PubMed , DOI )

Maeda Kenji, Matsuda Kouki, Islam Saiful, Kobayakawa Takuya, Tsuchiya Kiyoto, Hattori Shin-ichiro, Gatanaga Hiroyuki, Oka Shinichi, Yoshimura Kazuhisa, Tamamura Hirokazu, Mitsuya Hiroaki, Satou Yorifumi: HIV持続潜伏感染に関する最先端研究(Treatment of HIV-1-reservoirs using latency-reversing agents(LRAs) toward HIV cure) 日本エイズ学会誌. 2019.11; 21 (4): 314. ( 医中誌 )

Hwang D, Tsuji K, Park H, Burke TR Jr, Rader C: Site-Specific Lysine Arylation as an Alternative Bioconjugation Strategy for Chemically Programmed Antibodies and Antibody-Drug Conjugates. Bioconjugate chemistry. 2019.11; 30 (11): 2889-2896. ( PubMed , DOI )

Park SW, Nhieu J, Persaud SD, Miller MC, Xia Y, Lin YW, Lin YL, Kagechika H, Mayo KH, Wei LN: Publisher Correction: A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1. Scientific reports. 2019.11; 9 (1): 17042. ( PubMed , DOI )

Mohammad Mamun Alam, Takeo Kuwata, Kazuki Tanaka, Muntasir Alam, Shokichi Takahama, Kazuya Shimura, Masao Matsuoka, Natsuki Fukuda, Hiroshi Morioka, Hirokazu Tamamura, Shuzo Matsushita: Synergistic Inhibition of Cell-to-cell HIV-1 Infection by Combinations of Single Chain Variable Fragments and Fusion Inhibitors Biochem Biophys Rep.. 2019.09; 20 100687.

Masuno Hiroyuki, Kazui Yuko, Tanatani Aya, Fujii Shinya, Kawachi Emiko, Ikura Teikichi, Ito Nobutoshi, Yamamoto Keiko, Kagechika Hiroyuki: Development of novel lithocholic acid derivatives as vitamin D receptor agonists BIOORGANIC & MEDICINAL CHEMISTRY. 2019.08; 27 (16): 3674-3681. ( PubMed , DOI )

Takuya Kobayakawa, Kento Ebihara, Yuzuna Honda, Masayuki Fujino, Wataru Nomura, Naoki Yamamoto, Tsutomu Murakami, Hirokazu Tamamura: Dimeric C34 Derivatives Linked through Disulfide Bridges as New HIV-1 Fusion Inhibitors. Chembiochem. 2019.08; 20 (16): 2101-2108. ( PubMed , DOI )

Ayae Sugawara-Narutaki, Sachio Tsuboike, Yukari Oda, Atsushi Shimojima, Kira Landenberger, Tatsuya Okubo, Sadahito Aoshima: Bioinspired Approach to Silica Nanoparticle Synthesis Using Amine-Containing Block Copoly(vinyl ethers): Realizing Controlled Anisotropy Langmuir. 2019.07; 35 (33): 10846-10854-10854. ( PubMed , DOI )

Kenji Maeda, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura, Hiroaki Takeuchi: Discovery and Development of anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication. Current topics in medicinal chemistry. 2019.07; 19 (18): 1621-1649. ( PubMed , DOI )

Kawahara Haruka, Miyashita Naoki, Tachibana Koki, Tsuda Yusuke, Morimoto Kyohei, Tsuji Kohei, Shigenaga Akira, Otaka Akira, Ishida Tatsuhiro, Okuhira Keiichiro: A Photo-Activatable Peptide Mimicking Functions of Apolipoprotein A-I BIOLOGICAL & PHARMACEUTICAL BULLETIN. 2019.06; 42 (6): 1019-1024.

Maxwell M Sakyiamah, Wataru Nomura, Takuya Kobayakawa, Hirokazu Tamamura: Development of a NanoBRET-Based Sensitive Screening Method for CXCR4 Ligands. Bioconjug. Chem.. 2019.05; 30 (5): 1442-1450. ( PubMed , DOI )

Duc H. T. Le, Ayae Sugawara-Narutaki: Elastin-Like Polypeptides as Building Motifs toward Designing Functional Nanobiomaterials Mol. Syst. Des. Eng.. 2019.05; 4 545-565. ( DOI )

Zhao XZ, Tsuji K, Hymel D, Burke TR Jr: Development of Highly Selective 1,2,3-Triazole-containing Peptidic Polo-like Kinase 1 Polo-box Domain-binding Inhibitors. Molecules (Basel, Switzerland). 2019.04; 24 (8): 1488. ( PubMed , DOI )

Ishigami-Yuasa, M.; Ekimoto, H.; Kagechika, H.: Class IIb HDAC inhibition enhances the inhibitory effect of Am80, a synthetic retinoid, in prostate cancer Biol. Pharm. Bull.. 2019.03; 42 (3): 448-452. ( PubMed , DOI )

Takuya Kobayakawa, Kiju Konno, Nami Ohashi, Kohei Takahashi, Ami Masuda, Kazuhisa Yoshimura, Shigeyoshi Harada, Hirokazu Tamamura: Soluble-type small-molecule CD4 mimics as HIV entry inhibitors BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2019.03; 29 (5): 719-723. ( PubMed , DOI )

Hogan M, Bahta M, Tsuji K, Nguyen TX, Cherry S, Lountos GT, Tropea JE, Zhao BM, Zhao XZ, Waugh DS, Burke TR Jr, Ulrich RG: Targeting Protein-Protein Interactions of Tyrosine Phosphatases with Microarrayed Fragment Libraries Displayed on Phosphopeptide Substrate Scaffolds. ACS combinatorial science. 2019.03; 21 (3): 158-170. ( PubMed , DOI )

Maxwell M. Sakyiamah, Takuya Kobayakawa, Masayuki Fujino, Makoto Konno, Tetsuo Narumi, Tomohiro Tanaka, Wataru Nomura, Naoki Yamamoto, Tsutomu Murakami, Hirokazu Tamamura: Design, synthesis and biological evaluation of low molecular weight CXCR4 ligands BIOORGANIC & MEDICINAL CHEMISTRY. 2019.03; 27 (6): 1130-1138. ( PubMed , DOI )

Akinobu Z. Suzuki, Ryota Sekine, Shiori Takeda, Ryosuke Aikawa, Yukiko Shiraishi, Tomomi Hamaguchi, Hiroyuki Okuno, Tamamura Hirokazu, Furuta Toshiaki: A clickable caging group as a new platform for modular caged compounds with improved photochemical properties CHEMICAL COMMUNICATIONS. 2019.01; 55 (4): 451-454. ( PubMed , DOI )

Kouki Matsuda, Takuya Kobayakawa, Kiyoto Tsuchiya, Shin-Ichiro Hattori, Wataru Nomura, Hiroyuki Gatanaga, Kazuhisa Yoshimura, Shinichi Oka, Yasuyuki Endo, Hirokazu Tamamura, Hiroaki Mitsuya, Kenji Maeda: Benzolactam-related compounds promote apoptosis of HIV-infected human cells via protein kinase C-induced HIV latency reversal. J. Biol. Chem.. 2019.01; 294 (1): 116-129. ( PubMed , DOI )

Yokoo, H.; Kagechika, H.; Ohsaki, A; Hirano T.: A Polarity-Sensitive Fluorescent Amino Acid and its Incorporation into Peptides for the Ratiometric Detection of Biomolecular Interactions ChemPlusChem. 2019; 84 1716-1719. ( DOI )

Mori, S.; Tsuemoto, N.; Kasagawa, T.; Nakano, E.; Fujii, S.; Kagechika, H.: Development of Boron-Cluster-Based Progesterone Receptor Antagonists Bearing a Pentafluorosulfanyl (SF5) Chem. Pharm. Bull.. 2019; 67 (12): 1278-1283.

Mori, S.; Iinuma, H.; Manaka, N.; Ishigami-Yuasa, M.; Murayama, T.; Nishijima, Y.; Sakurai, A.; Arai, R.; Kurebayashi, N.; Sakurai, T.; Kagechika, H.: Structural development of a type-1 ryanodine receptor (RyR1) Ca2+-release channel inhibitor guided by endoplasmic reticulum Ca2+ assay Eur. J. Med. Chem.. 2019; 179 837-848. ( PubMed , DOI )

Endo, Y.; Sugiura, Y.; Funasaki, M.; Kagechika, H.; Ishibashi, M.; Ohsaki, A.: Two new alkaloids from Crinum asiaticum var. japonicum. J. Nat. Med.. 2019; 73 (3): 648-652. ( PubMed , DOI )

Kaitoh, K.; Nakatsu, A.; Mori, S.; Kagechika, H.; Hashimoto, Y.; Fujii, S.: Design, synthesis and biological evaluation of novel nonsteroidal progesterone receptor antagonists based on phenylamino-1,3,5-tirazine scaffold Chem. Pharm. Bull.. 2019; 67 (6): 566-575. ( PubMed , DOI )

Park, S. W.; Nhieu, J.; Persaud, S. D.; Miller, M. C.; Xia, Y.; Lin, Y.-W.; Lin, Y.-L.; Kagechika, H.; Mayo, K. H.; Wei, L.-N.: A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1 Sci. Rep.. 2019; 9 10929. ( DOI )

McDonald, M. G.; Yeung, C. K.; Teitelbaum, A. M.; Johnson, A. L.; Fujii, S.; Kagechika, H.; A New LC-MS Assay for the Quantitative Analysis of Vitamin K Metabolites in Human Urine Rettie, A. E.: A New LC-MS Assay for the Quantitative Analysis of Vitamin K Metabolites in Human Urine J. Lipid Res.. 2019; 60 (4): 892-899. ( DOI )

Kanda, M.; Urushibara, Ko.; Park, S.; Fujii, S.; Masu, H.; Katagiri, K.; Azumaya, I.; Kagechika, H.; Tanatani, A.: Spontaneous Chiral Resolution of N,N’-Diarylsquaramides : Formation of Various Types of One-handed Helical Networks During Crystallization Tetrahedron . 2019; 75 (19): 2771-2777. ( DOI )

Fujii, S.; Yanagida, N.; Mori, S.; Kawachi, E.; Kagechika, H: Design and synthesis of cyclohexyl-p-carborane derivatives as a new class of progesterone receptor antagonists Heterocycles . 2019; 99 (1): 425-445. ( DOI )

Mori S, Tsuemoto N, Kasagawa T, Nakano E, Fujii S, Kagechika H: Development of Boron-Cluster-Based Progesterone Receptor Antagonists Bearing a Pentafluorosulfanyl (SF₅) Group. Chemical & pharmaceutical bulletin. 2019; 67 (12): 1278-1283. ( PubMed , DOI )

Urushibara, K.; Masu, H.; Mori, H.; Azumaya, I.; Hirano, T.; Kagechika,H.; Tanatani, A. : Synthesis and Conformational Analysis of Alternately N-Alkylated Aromatic Amide Oligomers J. Org. Chem.. 2018.11; 83 (23): 14338-14349. ( PubMed , DOI )

Takuya Kobayakawa, Nami Ohashi, Yuki Hirota, Kohei Takahashi, Yuko Yamada, Tetsuo Narumi, Kazuhisa Yoshimura, Shuzo Matsushita, Shigeyoshi Harada, Hirokazu Tamamura: Flexibility of small molecular CD4 mimics as HIV entry inhibitors. Bioorg. Med. Chem.. 2018.11; 26 (21): 5664-5671. ( PubMed , DOI )

Wataru Nomura, Daisuke Matsumoto, Taisuke Sugii, Takuya Kobayakawa, Hirokazu Tamamura: Efficient and Orthogonal Transcription Regulation by Chemically Inducible Artificial Transcription Factors. Biochemistry. 2018.11; 57 (45): 6452-6459. ( PubMed , DOI )

Kazui, Y.; Fujii, S.; Yamada, A.; Ishigami-Yuasa, M.; Kagechika, H.; Tanatani, A.: Structure-Activity Relationship of Novel Androgen Receptor Antagonists Bearing a (Benzoylaminophenoxy)phenol Pharmacophore. Bioorg. Med. Chem.. 2018.10; 26 (18): 5118-5127. ( PubMed , DOI )

Timalsina, S.; Arimoto-Matsuzaki, K.; Kitamura, M.; Xu, X.; Wenzhe, Q.; Ishigami-Yuasa, M.; Kagechika, H.; Hata, Y.: Chemical compounds that suppress hypoxia-induced stress granule formation enhance cancer drug sensitivity of human cervical cancer HeLa cells. J. Biochem.. 2018.10; 164 (5): 381-391. ( PubMed , DOI )

Hymel D, Grant RA, Tsuji K, Yaffe MB, Burke TR Jr: Histidine N(τ)-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors. Bioorganic & medicinal chemistry letters. 2018.10; 28 (19): 3202-3205. ( PubMed , DOI )

Loppi, S.; Kolosowska, N.; Kärkkäinen, O.; Korhonen, P.; Huuskonen, M.; Grubman, A.; Dhungana, H.; Wojciechowski, S.; Pomeshchik, Y.; Giordano, M.; Kagechika, H.; White, A.; Auriola, S.; Koistinaho, J.; Landreth, G.; Hanhineva, K.; Kanninen, K.; Malm, T.: HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, preventsischemia-induced neuronal damag Brain Behav. Immunol.. 2018.09; 73 670-681. ( DOI )

Li, M.; Qin, X.-Y.; Furutani, Y.; Inoue, I.; Sekihara, S.; Kagechika, H.; Kojima S.: Prevention of acute liver injury by suppressing plasma kallikrein-dependent activation of latent TGF-β Biochem. Biophys. Res. Chem.. 2018.09; 504 (4): 857-864. ( PubMed , DOI )

Hirano, T.; Fujiwara, T.; Niwa, H.; Hirano, M.; Ohira, K.; Okazaki, Y.; Sato, S.; Umehara, T.; Maemoto, Y.; Ito, A.; Yoshida, M.; Kagechika, H.: Development of novel inhibitors for histone methyltransferase SET7/9 based on cyproheptadine ChemMedChem. 2018.08; 13 (15): 1530-1540. ( PubMed , DOI )

Nishiyama, Y.; Mori, S.; Makishima, M.; Fujii, S.; Kagechika, H.; Hashimoto, Y.; Ishikawa, M.: Novel non-steroidal progesterone receptor (PR) antagonists with a phenanthridinone skeleton. ACS Med. Chem. Lett.. 2018.07; 9 (7): 641-645. ( PubMed , DOI )

Atsumi Chisato, Araoka Shintaro, Landenberger Kira B, Kanazawa Arihiro, Nakamura Jin, Ohtsuki Chikara, Aoshima Sadahito, Sugawara-Narutaki Ayae: Ring-Like Assembly of Silica Nanospheres in the Presence of Amphiphilic Block Copolymer: Effects of Particle Size LANGMUIR. 2018.07; 34 (26): 7751-7758-7758. ( PubMed , DOI )

Fujii, S.; Mori, S.; Kagechika, H.; Parra, M. A. M.; Gronemeyer, H.: Development of biotin-retinoid conjugates as chemical probes for analysis of retinoid function. Bioorg. Med. Chem. Lett.. 2018.07; 28 (14): 2442-2445. ( PubMed , DOI )

Kei Toyama, Wataru Nomura, Takuya Kobayakawa, Hirokazu Tamamura: Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR. Bioconjug. Chem.. 2018.06; 29 (6): 2050-2057. ( PubMed , DOI )

Qin, X.-Y.; Suzuki, H.; Honda, M.; Okada, H.; Kaneko, S.; Inoue, I.; Ebisui, E.; Hashimoto, K.; Carninci, P.; Kanki, K.; Tatsukawa, H.; Ishibashi, N.; Masaki, T.; Matsuura, T.; Kagechika, H.; Toriguchi, K.; Hatano, E.; Shirakami, Y.; Shiota, G.; Shimizu, M.; Moriwaki, H.; Kojima, S. : Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid. Proc. Nat. Acad. Sci. USA. 2018.06; 115 (19): 4969-4974. ( PubMed , DOI )

Murayama, T.; Kurebayashi, Ishigami-Yuasa, M.; Mori, A.; Suzuki, Y.; Akima, R.; Ogawa, H.; Suzuki, J.; Kanemaru, K.; Oyamada, H.; Kiuchi, Y.; Iino, K.; Kagechika, H.; Sakurai, T. : Efficient High-Throughput Screening by Endoplasmic Reticulum Ca2+ Measurement to Identify Inhibitors of Ryanodine Receptor Ca2+-Release Channels Mol. Pharmacol. . 2018.06; 94 (1): 722-730. ( PubMed , DOI )

Wataru Nomura, Daisuke Matsumoto, Taisuke Sugii, Takuya Kobayakawa: Chemically-controlled orthogonal regulation of multiple endogenous genes FASEB Journal. 2018.04; 32 (1):

Ando F, Mori S, Yui N, Morimoto T, Nomura N, Sohara E, Rai T, Sasaki S, Kondo Y, Kagechika H, Uchida S: AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus Nat Commun. 2018.04; 9 (1): 1411. ( PubMed , DOI )

Shu Shimada, Yoshimitsu Akiyama, Kaoru Mogushi, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiromi Nagasaki, Hiroshi Fukamachi, Yasuhito Yuasa, Shinji Tanaka: Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models. Br. J. Cancer. 2018.04; 118 (7): 972-984. ( PubMed , DOI )

Tojo, Y.; Urushibara, K.; Yamamoto, S.; Mori, H.; Masu, H.; Kudo, M.; Hirano, T.; Azumaya, I.; Kagechika, H.; Tanatani, A.: Conformational Properties of Aromatic Oligoamides Bearing Pyrrole Rings. J. Org. Chem.. 2018.04; 83 (8): 4606-4617. ( PubMed , DOI )

Park, S.; Uchida, J.; Urushibara, K.; Kagechika, H.; Kato, T.; Tanatani, A.: Self-assembly of Liquid-crystalline Squaramides. Chem. Lett.. 2018.04; 47 (4): 601-604. ( DOI )

Urushitani, H.; Katsu, Y.; Kagechika, H.; Sousa, A. C. A.; Barroso, C. M.; Ohta, Y.; Shiraishi, H.; Iguchi, T.; Horiguchi, T.: Characterization and comparison of transcriptional activities of the retinoid X receptors by various organotin compounds in three prosobranch gastropods; Thais clavigera, Nucella lapillus and Babylonia japonica. Aquatic Toxicol. . 2018.04; 199 103-115. ( PubMed , DOI )

Yokoo, H.; Ohsaki, A.; Kagechika, H.; Hirano, T.: Unique properties of 1,5-naphthyridin-2(1H)-one derivatives as environmental-polarity-sensitive fluorescent dyes. Eur. J. Org. Chem.. 2018.03; 2018 (5): 679-687. ( DOI )

Junichi Maruyama, Kazutoshi Inami, Fumiyoshi Michishita, Xinliang Jiang, Hiroaki Iwasa, Kentaro Nakagawa, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Norio Miyamura, Jun Hirayama, Hiroshi Nishina, Daichi Nogawa, Kouhei Yamamoto, Yutaka Hata: Novel YAP1 Activator, Identified by Transcription-Based Functional Screen, Limits Multiple Myeloma Growth. Mol. Cancer Res.. 2018.02; 16 (2): 197-211. ( PubMed , DOI )

Takuya Kobayakawa, Yudai Matsuzaki, Kentaro Hozumi, Wataru Nomura, Motoyoshi Nomizu, Hirokazu Tamamura: Synthesis of a Chloroalkene Dipeptide Isostere-Containing Peptidomimetic and Its Biological Application. ACS Medicinal Chemistry Letters. 2018.01; 9 (1): 6-10. ( PubMed , DOI )

Kei Toyama, Takuya Kobayakawa, Wataru Nomura, Hirokazu Tamamura: Inhibition of EGFR Activation by Bivalent Ligands Based on a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR. Chem. Pharm. Bull.. 2018; 66 (11): 1083-1089. ( PubMed , DOI )

Mori, S.; Takagaki, R.; Fujii, S.; Urushibara, K.; Tanatani, A.; Kagechika, H.: Novel non-steroidal progesterone receptor ligands based on m-carborane containing a secondary alcohol: effect of chirality on ligand activity Chem. Pharm. Bull.. 2017.11; 65 (11): 1051-1057. ( PubMed , DOI )

Endo,Y.; Kasahara,T.; Harada,K.; Kubo, M.; Etoh, T.; Ishibashi, M.; Ishiyama, A.; Iwatsuki, M.; Otoguro, K.; Ohmura, S.; Akisue, G.; Hirano, T.; Kagechika, H.; Fukuyama, Y.; Ohsaki, A.: Sucupiranins A−L, Furanocassane Diterpenoids from the Seeds of Bowdichia virgilioides. J. Nat. Prod. . 2017.11; 80 (12): 3120-3127. ( PubMed , DOI )

Tanegashima Kosuke, Takahashi Rena, Nuriya Hideko, Iwase Rina, Naruse Naoto, Tsuji Kohei, Shigenaga Akira, Otaka Akira, Hara Takahiko: CXCL14 Acts as a Specific Carrier of CpG DNA into Dendritic Cells and Activates Toll-like Receptor 9-mediated Adaptive Immunity EBIOMEDICINE. 2017.10; 24 247-256. ( PubMed , DOI )

Hoang, H. N.; Granero-Fernandez, E.; Yamada, S.; Mori, S.; Kagechika, H.; Medina-Gonzalez, Y.; Matsuda, T.: Modulating Biocatalytic Activity toward Sterically Bulky Substrates in CO2-Expanded Biobased Liquids by Tuning the Physicochemical Properties. ACS Sus. Chem. Eng.. 2017.10; 5 (11): 11051-11059. ( DOI )

Le DHT, Tsutsui Y, Sugawara-Narutaki A, Yukawa H, Baba Y, Ohtsuki C: Double-hydrophobic elastin-like polypeptides with added functional motifs: Self-assembly and cytocompatibility. Journal of biomedical materials research. Part A. 2017.09; 105 (9): 2475-2484. ( PubMed , DOI )

Yamasaki, R.; Iida, M.; Ito, A.; Fukuda, K.; Tanatani, A.; Kagechika, H., Masu, H. Okamoto, I. : Crystal Engineering of N,N’-Diphenylurea Compounds Featuring Phenyl-Perfluorophenyl Interaction Crystal Growth Des.. 2017.09; 17 5858-5866.

Suzuki, D.; Saito-Hakoda, A.; Ito, R.; Shimizu, K.; Parvin, R.; Shimada, H.; Noro, E.; Suzuki, S.; Fujiwara, I.; Kagechika, H.; Rainey, W. E.; Kure, S.; Ito, S.; Yokoyama, A.; Sugawara, A. : Suppressive effects of RXR agonist PA024 on adrenal CYP11B2 expression, aldosterone secretion and blood pressure Plos ONE. 2017.08; 12 (8): e0181055. ( PubMed , DOI )

Nomura Wataru, Matsumoto Daisuke, Hashimoto Tsukasa, Sugii Taisuke, Tamamura Hirokazu: Development of chemical-inducible artificial transcription factors based on sequence-specific DNA binders ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2017.08; 254

Ohashi N, Kobayashi R, Nomura W, Kobayakawa T, Czikora A, Herold B K, Lewin N E, Blumberg P M, Tamamura H: Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol-Lactones as Protein Kinase C Ligands. Bioconjugate Chem. 2017.07; ( DOI )

Takuya Kobayakawa, Hirokazu Tamamura: Stereoselective synthesis of Xaa-Yaa type (Z)-chloroalkene dipeptide isosteres via efficient utilization of organocopper reagents mediated allylic alkylation Tetrahedron. 2017.07; 73 (30): 4464-4471. ( DOI )

Mori, S.; Hirano T.; Takaguchi, A.; Fujiwara, T.; Okazaki, Y.; Kagechika, H.: Selective Reagent for Detection of N-ε-Monomethylation of a Peptide Lysine Residue through SNAr Reaction European Journal of Organic Chemistry. 2017.07; 3606-3611.

Yoshioka, H.; Yamada, A.; Nishiyama, Y.; Kagechika, H.; Hashimoto, Y.; Fujii, S.: Development of nonsteroidal glucocorticoid receptor modulators based on N-benzyl-N-(4-phenoxyphenyl)benzenesulfonamide scaffold Bioorganic and Medicinal Chemistry. 2017.07; 25 (13): 3461-3470.

Yoshizaki, Y.; Mori, T.; Ishigami-Yuasa, M.; Kikuchi, E.; Takahashi, D.; Zeniya, M.; Nomura, N.; Mori, Y.; Araki, Y.; Ando, F.; Mandai, S.; Kasagi, Y.; Arai, Y.; Sasaki, E.; Yoshida, S.; Kagechika, H.; Rai, T.; Uchida, S.; Sohara, E.: Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation Spectroscopy Science Reports. 2017.07; 7 3945.

Kobayakawa Takuya, Tamamura Hirokazu: Stereoselective synthesis of Xaa-Yaa type (Z)-chloroalkene dipeptide isosteres via efficient utilization of organocopper reagents mediated allylic alkylation TETRAHEDRON. 2017.07; 73 (30): 4464-4471. ( DOI )

Ishigami-Yuasa, M.; Watanabe, Y.; Mori, T.; Masuno, H.; Fujii, S.; Kikuchi, E.; Uchida, S.; Kagechika, H.: Development of WNK signaling inhibitors as a new class of antihypertensive drugs Bioorganic and Medicinal Chemistry. 2017.06; 25 (14): 3845-3852.

Nguyen, B. N.; Okuno, Y.; Ajiro, M.; Iida, K.; Denawa, M.; Yamamoto, M.; Sakamoto, N.; Kagechika, H.; Hagiwara, M.: Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression Journal of Medical Virology. 2017.05; 89 (7): 1224-1234.

Hoang, H. N.; Nagashima, Y.; Mori, S.; Kagechika, H.; Matsuda, T.: CO2-expanded bio-based liquids as novel solvents for enantioselective biocatalysis Tetrahedron . 2017.05; 73 (20): 2984-2989.

Kobayashi K, Mizuguchi T, Hattori Y, Ohara N, Ninomiya R, Iida M, Ooe H, Yamazaki Y, Takata M, Tamamura H, Akaji K: Effects of Replacement and Addition of an Amino Acid Contained in a Cyclic Peptide Corresponding to a β-Hairpin Loop Sequence of Human EGF Receptor. J. Pept. Sci. 2017.04; ( DOI )

Perri, M.; Caroleo, Nannan M. C.; Gallelli, L. L.; De Sarro, G.; Kagechika, H.; Cione, E.: 9-cis Retinoic acid modulates myotrophin expression and its miR in physiological and pathophysiological cell models Experimental Cell Research. 2017.04; 354 25-30.

Takuya Kobayakawa: Synthetic Studies on Chloroalkene Dipeptide Isosteres as Peptidomimetics 国立大学法人 東京医科歯科大学. 2017.03;

Tsuji, M.; Shudo, K.; Kagechika, H.: The receptor subtype selectivity of retinoid X and retinoic acid re-ceptors via quantum mechanics FEBS Open Bio. 2017.03; 7 391-396.

Takano Hikaru, Narumi Tetsuo, Nomura Wataru, Tamamura Hirokazu: Microwave-Assisted Synthesis of Azacoumarin Fluorophores and the Fluorescence Characterization JOURNAL OF ORGANIC CHEMISTRY. 2017.03; 82 (5): 2739-2744. ( PubMed , DOI )

Takano T, Narumi T, Nomura W, Tamamura H: Microwave-Assisted Synthesis of Azacoumarin Fluorophores and the Fluorescence Characterization. J. Org. Chem. 2017.02; 82 (5): 2739-2744.

Tanaka T, Aoki T, Nomura W, Tamamura H : Bivalent 14-mer Peptide Ligands of CXCR4 with Polyproline Linkers with Anti-Chemotactic Activity against Jurkat Cells. J. Pept. Sci. 2017.01; ( DOI )

Mizuguchi T, Ohashi N, Matsumoto D, Hashimoto C, Nomura W, Yamamoto N, Murakami T, Tamamura: Development of Anti-HIV Peptides Based on a Viral Capsid Protein. Biopolymers: Peptide Science. 2017.01; 108 (1): ( DOI )

Oya, Y.; Mondal, A.; Rawangkan, A.; Umsumarng, S.; Iida, K.; Watanabe, T.; Kanno, M.; Suzuki, K.; Li, Z.; Kagechika, H.; Shudo, K.; Fujiki, H.; Suganuma, M.: Down-regulation of histone deacetylase 4, −5 and −6 as a mechanism of synergistic enhancement of apoptosis in human lung cancer cells treated with the combination of a synthetic retinoid, Am80 and green tea catechin Journol of Nutritional Biochemistry. 2017.01; 42 7-16.

Okamoto-Uchida, Y.; Yu, R.; Miyamura, N.; Arima, N.; Ishigami-Yuasa, M.; Kagechika, H.; Yoshida, S.; Hosoya, T.; Nawa, M.; Kasama, T.; Asaoka, Y.; Alois, R. W.; Elling, U.; Penninger, J. M.; Nishina, S.; Azuma, N.; Nishina, H.: The mevalonate pathway regulates primitive streak formation via protein farnesylation Science Reports. 2016.10; 6 37697.

Kinoshita, M.; Negishi, M.; Sakai, H.; Hirano, T.; Mori, S.; Fujii, S.; Kagechika, H.; Tanatani, A.: Development of 6-Arylcoumarins as Nonsteroidal Progesterone Antagonists. Structure-activity Relationships and Fluorescence Properties Bioorganic & Medicinal Chemistry. 2016.09; 24 (21): 5602-5610.

Yamada, A.; Kazui, Y.; Yoshioka, H.; Tanatani, A.; Mori, S.; Kagechika, H.; Fujii, S. : Development of N-(4-Phenoxyphenyl)benzenesulfonamide Derivatives as Novel Nonsteroidal Progesterone Receptor Antagonists ACS Medicinal Chemistry Letters. 2016.09; 7 (12): 1028-1033.

Takuya Kobayakawa, Hirokazu Tamamura: Efficient synthesis of Xaa-Gly type (Z)-chloroalkene dipeptide isosteres via organocuprate mediated reduction Tetrahedron. 2016.08; 72 (32): 4968-4971. ( DOI )

Kobayakawa Takuya, Tamamura Hirokazu: Development of synthetic methodology of chloroalkene-type dipeptide isosteres for peptidomimetics ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2016.08; 252

Mitsuhiro Eto, Naoto Naruse, Kyohei Morimoto, Kosuke Yamaoka, Kohei Sato, Kohei Tsuji, Tsubasa Inokuma, Akira Shigenaga, Akira Otaka: Development of an Anilide-Type Scaffold for the Thioester Precursor N-Sulfanylethylcoumarinyl Amide. Org. Lett.. 2016.08; 18 (17): 4416-4419. ( PubMed , DOI )

Yokoo, H.; Ohsaki, A.; Kagechika, H.; Hirano T.: Structural development of canthin-5,6-dione moiety as a fluorescent dye and its application to novel fluorescent sensors Tetrahedron . 2016.08; 72 5872-5879.

Fujiwara, T.; Ohira, K.; Urushibara, K.; Ito, A.; Yoshida, M.; Kanai, M.; Tanatani, A.; Kagechika, H.; Hirano, T.: Steric structure–activity relationship of cyproheptadine derivatives as inhibitors of histone methyltransferase Set7/9 Bioorganic & Medicinal Chemistry. 2016.07; 24 4318-4323.

Hirano, T.; Noji, Y.; Shiraishi, T.; Ishigami-Yuasa, M.; Kagechika, H.: Development of an “OFF-ON-OFF” fluorescent pH sensor suitable for the study of intracellular pH Tetrahedron . 2016.06; 72 4925-4930.

Nagashima, S.; Maruyama, J.; Kawano, S.; Iwasa, H.; Nakagawa, K.; Ishigami-Yuasa, M.; Kagechika, H.; Nishina, H.; Hata, Y.: Validation of the chemical compound library screening for TAZ inhibitors by use of green fluorescence protein-fused TAZ Cancer Science. 2016.06; 107 (6): 791-802.

Takemoto, Y.; Ito, A.; Niwa, H.; Okamura, M.; Fujiwara, T.; Hirano, T.; Handa, N.; Umehara, T.; Sonoda, T.; Ogawa, K.; Tariq, M.; Nishino, N.; Dan, S.; Kagechika, H.; Yamori, T.; Yokoyama, S.; Yoshida, M.: Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription Journol of Medicinal Chemistry. 2016.04; 59 (8): 3650-3660.

Takuya Kobayakawa, Tetsuo Narumi, Hirokazu Tamamura: Stereoselective Synthesis of Chloroalkene Dipeptide Isosteres Utilizing Organocopper Reagents PEPTIDE SCIENCE 2015. 2016.03; 97-98.

Persaud, S. D.; Park, S. W.; Ishigami-Yuasa, M.; Koyano-Nakagawa, N.;, Kagechika, H.; Wei, L.-N.: All trans-retinoic acid analogs promote cancer cell apoptosis through non-genomic Crabp1 mediating ERK1/2 phosphorylation Science Reports. 2016.03; 6 22396.

Tsukada, H.; Kawabe, H.; Ohtaka, A.; Saito, Y.: Okamoto, Y.: Tori, M.; Kagechika, H.; Hirota, H.; Gong, X.; Kuroda, C.; Ohsaki, A.: Two new diterpenoids from Salvia przewarskii Natural Product Communications. 2016.01; 11 (2): 159-161.

Ohashi N, Harada S, Mizuguchi T, Irahara Y, Yamada Y, Kotani M, Nomura W, Matsushita S, Yoshimura K, Tamamura H: Small Molecular CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors. ChemMedChem a joint special issue with ChemBioChem: Protein–Protein Interactions. 2016; 11 (8): 940-946.

Hiramatsu K, Tamamura H: A Mild Method for the Direct Fluorination of Pyrroles by Using a Lipophilic Anionic Phase-Transfer Catalyst. Eur. J. Org. Chem. 2016; 21 3491-3494.

Toyama K, Mizuguchi T, Nomura W, Tamamura H: Functional Evaluation of Fluorescein-Labeled Derivatives of a Peptide Inhibitor of the EGF Receptor Dimerization Bioorg. Med. Chem. 2016; 24 (16): 3406-3412.

Mizuguchi T, Harada S, Miura T, Ohashi N, Narumi T, Mori H, Irahara Y, Yamada Y, Nomura W, Matsushita S, Yoshimura K, Tamamura H: A Minimally Cytotoxic CD4 Mimic as an HIV Entry Inhibitor Bioorg. Med. Chem. Lett . 2016; 2 (26): 397-400.

Abduelmula A, Huang R, Pu Q, Tamamura H, Puopolo G. M & Saberi B. B: SDF-1 Controls the Muscle and Blood Vessel Formation of the Somite. Int. J. Dev. Biol. 2016; 60(1-2-3) (29-38):

Plant opal-mimetic bunching silica nanoparticles mediated by long-chain polyethyleneimine 2016; 6 (2): 1301-1306. ( DOI )

Takano H, Narumi T, Nomura W, Tamamura H: Microwave-Assisted Synthesis of Azacoumarin Fluorophores and the Fluorescence Characterization J. Org. Chem. 2016; in press

Nakamura T, Campbell J.R, Moore A.R, Otsu S, Aikawa H, Tamamura H, Mitsuya H: Development and Validation of a Cell-based Assay System to Assess Human Immunodeficiency Virus Type 1 Integrase Multimerization J. Virol. Methods. 2016; 236 196-206.

Nomura W, Mizuguchi T & Tamamura H: Multimerized HIV-gp41-derived Peptides as Fusion Inhibitors and Vaccines Biopolymers: Peptide Science. 2016; 106 (4): 622-628.

Shrestha, R.; Tatsukawa, H.; Shrestha, R.; Ishibashi, N.; Matsuura, T.; Kagechika, H.; Kose, S.; Hitomi, K.; Imamoto, N.; Kojima, S.: Molecular mechanism by which acyclic retinoid induces nuclear localization of transglutaminase 2 in human hepatocellular carcinoma cells. Cell Death & Disease. 2015.12; 6 e2002. ( DOI )

Nanoparticle Vesicles with Controllable Surface Topographies through Block Copolymer-Mediated Self-Assembly of Silica Nanospheres 2015.12; 31 (48): 13214-13220. ( DOI )

Saito-Hakoda, A.; Uruno, A.; Yokoyama, A.; Shimizu, K.; Parvin, R.; Kudo, M.; Saito-Ito, T.; Sato, I.; Kogure, N.; Suzuki, D.; Shimada, H.; Yoshikawa, T .; Fujiwara, I.; Kagechika, H.; Iwasaki, Y.; Kure, S.; Ito, S.; Sugawara, A.: Effects of RXR Agonists on Cell Proliferation/Apoptosis and ACTH Secretion/Pomc Expression Plos ONE. 2015.11; 10 e0141960. ( DOI )

Yu. R.: Miyamura, N.; Okamoto-Uchida, Y.; Arima, N.; Ishigami-Yuasa, M.; Kagechika, H.; Nishina, H.: A Modified Murine Embryonic Stem Cell Test for Evaluating the Teratogenic Effects of Drugs on Early Embryogenesis Plos ONE. 2015.11; 10 e0145286. ( DOI )

Wataru Nomura, Takaaki Mizuguchi & Hirokazu Tamamura: Multimerized HIV-gp41-derived Peptides as Fusion Inhibitors and Vaccines Biopolymers: Peptide Science. 2015.11; ( DOI )

Kohei Tsuji, Kosuke Tanegashima, Kohei Sato, Ken Sakamoto, Akira Shigenaga, Tsubasa Inokuma, Takahiko Hara, Akira Otaka: Efficient one-pot synthesis of CXCL14 and its derivative using an N-sulfanylethylanilide peptide as a peptide thioester equivalent and their biological evaluation. Bioorg. Med. Chem.. 2015.09; 23 (17): 5909-5914. ( PubMed , DOI )

Chiharu Mizuguchi, Fuka Ogata, Shiho Mikawa, Kohei Tsuji, Teruhiko Baba, Akira Shigenaga, Toshinori Shimanouchi, Keiichiro Okuhira, Akira Otaka, Hiroyuki Saito: Amyloidogenic Mutation Promotes Fibril Formation of the N-terminal Apolipoprotein A-I on Lipid Membranes. J. Biol. Chem.. 2015.08; 290 (34): 20947-20959. ( PubMed , DOI )

Yusuke Tsuda, Akira Shigenaga, Kohei Tsuji, Masaya Denda, Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Tsubasa Inokuma, Kohji Itoh, Akira Otaka: Development of a Chemical Methodology for the Preparation of Peptide Thioesters Applicable to Naturally Occurring Peptides Using a Sequential Quadruple Acyl Transfer System. ChemistryOpen. 2015.08; 4 (4): 448-452. ( PubMed , DOI )

Kikuchi E, Mori T, Zeniya M, Isobe K, Ishigami-Yuasa M, Fujii S, Kagechika H, Ishihara T, Mizushima T, Sasaki S, Sohara E, Rai T, Uchida S: Discovery of novel SPAK inhibitors that block WNK kinase signaling to cation chloride transporters. J Am Soc Nephrol. 2015.07; 26 (7): 1525-1536. ( PubMed , DOI )

Takuya Kobayakawa, Tetsuo Narumi, Hirokazu Tamamura: Remote Stereoinduction in the Organocuprate-Mediated Allylic Alkylation of Allylic gem-Dichlorides: Highly Diastereoselective Synthesis of (Z)-Chloroalkene Dipeptide Isosteres. Organic Letters. 2015.05; 17 (10): 2302-2305. ( PubMed , DOI )

Cross linking-assisted Stabilization of Beaded Nanofibers from Elastin-like Double Hydrophobic Polypeptides 2015.04; 44 (4): 530-532. ( DOI )

Takuya Kobayakawa, Tetsuo Narumi, Hirokazu Tamamura: Development of Efficient Synthetic Methodologies of Chloroalkene Dipeptide Isosteres PEPTIDE SCIENCE 2014. 2015.03; 13-14.

Yuki Takechi-Haraya, Kento Tanaka, Kohei Tsuji, Yasuo Asami, Hironori Izawa, Akira Shigenaga, Akira Otaka, Hiroyuki Saito, Kohsaku Kawakami: Molecular complex composed of β-cyclodextrin-grafted Chitosan and pH-sensitive amphipathic peptide for enhancing cellular cholesterol efflux under acidic pH. Bioconjug. Chem.. 2015.03; 26 (3): 572-581. ( PubMed , DOI )

Beaded Nanofibers Assembled from Double-Hydrophobic Elastin-Like Block Polypeptides: Effects of Trifluoroethanol 2015.03; 103 (3): 175-185. ( DOI )

Ring assembly of silica nanospheres mediated by amphiphilic block copolymers with oxyethylene moieties 2015.02; 47 (2): 128-135. ( DOI )

Dendritic Silica Nanoparticles Synthesized by a Block Copolymer-Directed Seed-Regrowth Approach 2015.02; 31 (5): 1610-1614. ( DOI )

Hydroxyapatite formation on oxidized cellulose nanofibers in a solution mimicking body fluid 2015.02; 47 (2): 158-163. ( DOI )

Shiraishi, T.; Kagechika, H.; Hirano, T.: 6-Arylcoumarins: versatile scaffolds for fluorescent sensors New Journal of Chemistry. 2015; 39 8389-8396. ( DOI )

Tsuji, M.; Shudo, K.; Kagechika, H.: Docking simulations suggest that all-trans retinoic acid could bind to retinoid X receptors Journal of Computer Aided Molecular Design. 2015; 29 975-988. ( DOI )

Kawano, S.; Maruyama, J.; Nagashima, S.; Inami, K.; Qiu, W.; Iwasa, H.; Nakagawa, K.; Ishigami-Yuasa, M.; Kagechika, H.; Nishina, H.; Hata, Y.: A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells The Journal of Biochemistry. 2015; 158 413-420. ( DOI )

Brun, P.-J., Grijalva, A., Rausch, R., Watson, E., Yuen, J. J., Das, B. C., Shudo, K., Kagechika, H., Leibel, R. L., Blaner, W. S.: Retinoic acid receptor signaling is required to maintain glucose-stimulated insulin secretion and β-cell mass FASEB Journal. 2015; 26 671-683. ( DOI )

Mori, S., Takeuchi, Y., Tanatani, A., Kagechika, H., Fujii, S.: Development of 1,3-diphenyladamantane derivatives as nonsteroidal progesterone receptor antagonists Bioorganic Medicinal Chemistry. 2015; 23 803-809. ( DOI )

Nishiyama, S.; Urushibara, K.; Masu, H.; Azumaya, I.; Kagechika, H. Tanatani, A.: Conformational and chiral properties of cyclic-tri(N-methyl-meta-benzamide) bearing amidino groups Chirality. 2015; 27 487-491. ( DOI )

Inoue, K.; Urushibara, K.; Kanai, M.; Yura, K.; Fujii, S.; Ishigami-Yuasa, M.; Hashimoto, Y.; Mori, S.; Kawachi, E.; Matsumura, M.; Hirano, T.; Kagechik, H.; Tanatani, A.: Design and synthesis of 4-benzyl-1-(2H)-phthalazinone derivatives as novel androgen receptor antagonists European Journal of Medicinal Chemistry. 2015; 102 310-319. ( DOI )

Kodaka, M.; Yang, Z.; Nakagawa, K.; Maruyama, J.; Xu, X.; Sarkar, A.; Ichimura, A.; Nasu, Y.; Ozawa, T.; Iwasa, H.; Ishigami-Yuasa, M.; Ito, S.; Kagechika, H.; Hata, Y.: A new cell-based assay to evaluate myogenesis in mouse myoblast C2C12 cells Experimental Cell Research. 2015; 336 171-181. ( DOI )

Qin, X.-Y.; Fujii, S.; Shimizu, A.; Kagechika, H.; KOJIMA, S.: Carboxylic derivatives of vitamin K2 inhibit hepatocellular carcinoma cell growth through caspase/transglutaminase-related signaling pathways Journal of Nutritional Science and Vitaminology. 2015; 61 285-290.

Fujii, S.; Shimizu, A.; Takeda, N.; Oguchi, K.; Katsurai, T.; Shirakawa, H.; Komai, M.; Kagechika, H.: Systematic synthesis and anti-inflammatory activity of ω-carboxylated menaquinone derivatives - Investigations on identified and putative vitamin K2 metabolites - Bioorganic Medicinal Chemistry. 2015; 23 2344-2352.

Takano H, Narumi T, Nomura W, Furuta T, Tamamura H: Utilization of the Heavy Atom Effect for the Development of a Photosensitive 8-Azacoumarin-type Photolabile Protecting Group Org Lett. 2015; 21 (17): 5372-5375.

Nomura W, Aikawa H, Taketomi S, Tanabe M, Mizuguchi T, Tamamura H: Exploration of Labeling of Near Infrared Dyes on the Polyproline Linker for Bivalent-Type CXCR4 Ligands Bioorg Med Chem. 2015; 21 (23): 6967-6973.

Nomura W, Koseki T, Ohashi N, Mizuguchi T, Tamamura H: Trivalent Lignds for CXCR4 Bearing Polyproline Linkers Show Specific Recognition for Cells with Increased CXCR4 Expression. Org Biomol Chem. 2015; 32 (13): 8734-8739.

Mizuguchi T, Ohashi N, Nomura W, Komoriya M, Hashimoto C, Yamamoto N, Murakami T, Tamamura H: Anti-HIV Screening for Cell-Penetrating Peptides Using Chloroquine and Identification of Anti-HIV Peptides Derived from Matrix Proteins. Bioorg Med Chem. 2015; 15 (23): 4423-4427.

Nomura W, Ohashi N, Mori A, Tamamura H: An In-cell Fluorogenic Tag-probe System for Protein Dynamics Imaging Enabled by Cell-Penetrating Peptides. Bioconjugate Chem. 2015; 6 (26): 1080-1085.

Precision synthesis of polymers tailored towards directed formation and arrangement of silica nanomaterials 2014.08; 248

Amino Acid-assisted One-dimensional Assembly of Semiconducting Metal Oxide Nanoparticles in Aqueous Alcohol Media 2014.06; 43 (6): 934-935. ( DOI )

Emi Adachi, Asako Kosaka, Kohei Tsuji, Chiharu Mizuguchi, Hiroyuki Kawashima, Akira Shigenaga, Kohjiro Nagao, Kenichi Akaji, Akira Otaka, Hiroyuki Saito: The extreme N-terminal region of human apolipoprotein A-I has a strong propensity to form amyloid fibrils. FEBS Lett.. 2014.01; 588 (3): 389-394. ( PubMed , DOI )

Nami Ohashi, Wataru Nomura, Natsuki Minato & Hirokazu Tamamura : Screening for Protein Kinase C Ligands Using Fluorescence Resonance Energy Transfer. Chem. Pharm. Bull., . 2014; 62 (10): 1019-1025.

Synthesis of string-bean-like anisotropic titania nanoparticles with basic amino acids 2014; 4 (18): 9233-9235. ( DOI )

Fujii, S.; Kano, A.; Songkram, C.; Masuno, H.; Taoda, Y.; Kawachi, E.; Hirano, T.; Tanatani, A.; Kagechika, H.: Synthesis and structure-activity relationship of p-carborane-based non-secosteroidal vitamin D analogs. Bioorganic Medicinal Chemistry. 2014; 22 1227-1235. ( DOI )

Uruno, A.; Saito-Hakoda, A.; Yokoyama, A.; Kogure, N.; Matsuda, K.; Parvin, R.; Shimizu, K.; Sato, I.; Kudo, M.; Yoshikawa, T.; Kagechika, H.; Iwasaki, Y.; Ito, S.; Sugawara, A.: Retinoic acid receptor-α up-regulates proopiomelanocortin gene expression in AtT20 corticotroph cells. Endocrine Journol. 2014; 61 1105-1114. ( DOI )

Fujii, S.; Sekine, R.; Kano, A.; Masuno, H.; Songkram, C.; Kawachi, E.; Hirano, T.; Tanatani, A.; Kagechika, H.: Structural development of p-carborane-based potent non-secosteroidal vitamin D analogs Bioorganic Medicinal Chemistry. 2014; 22 5891-5901. ( DOI )

Fujii, S.; Nakano, E.; Yanagid, N.; Mori, S.; Masuno, H.; Kagechika, H.: Development of p-carborane-based nonsteroidal progesterone receptor antagonists Bioorganic Medicinal Chemistry. 2014; 22 5329-5337. ( DOI )

Fujii, S.; Yamada, A.; Nakano, E.; Takeuchi, Y.; Mori, S.; Masuno, H.; Kagechika, H.: Design and synthesis of nonsteroidal progesterone receptor antagonists based on C,C’-diphenylcarborane scaffold as a hydrophobic pharmacophore Europian Journol of Medicinal Chemistry. 2014; 84 264-277. ( DOI )

Fujii, S.; Kano, A.; Masuno, H.; Songkram, C.; Kawachi, E.; Hirano, T.; Tanatani, A.; Kagechika, H.: Design and synthesis of tetraol derivatives of　 1,12-dicarba-closo-dodecaborane as non-secosteroidal vitamin D analogs Bioorganic Medicinal Chemistry Letters. 2014; 24 4515-4519. ( DOI )

Yang, Z. Y.; Nakagawa, K.; Sarkar, A.; Maruyama, J.; Iwasa, H.; Bao, Y. J.; Ishigami-Yuasa, M.; Ito, S.; Kagechika, H.; Hata, S.; Nishina, H.; Abe, S.; Kitagawa, M.; Hata, Y.: Screening with a Novel Cell-Based Assay for TAZ Activators Identifies a Compound That Enhances Myogenesis in C2C12 Cells and Facilitates Muscle Repair in a Muscle Injury Model Molecular Cellular Biology. 2014; 34 1607-1621.

Fujii, S.; Kobayashi, T.; Nakatsu, A.; Miyazawa, H.; Kagechika, H.: Synthesis and Structure–Activity Relationship Study of Triazine-Based Inhibitors of the DNA Binding of NF-κB Chemical Pharmaceutical Bulletin. 2014; 62 700-708. ( DOI )

Tetsuo Narumi, Hikaru Takano, Nami Ohashi, Akinobu Suzuki, Toshiaki Furuta & Hirokazu Tamamura: Isostere-Based Design of 8-Azacoumarin-type Photolabile Protecting Groups: A Hydrophilicity Increasing Strategy for Coumarin-4-ylmethyls. Org. Lett.,. 2014; 16 (4): 1184-1187.

Jun Yamamoto, Masaya Denda, Nami Maeda, Miku Kita, Chiaki Komiya, Tomohiro Tanaka, Wataru Nomura, Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga & Akira Otaka: Development of a Traceable Linker Containing a Thiol-responsive Amino Acid for the Enrichment and Selective Labelling of Target Proteins. Org. Biomol. Chem.,. 2014; 12 (23): 3821-3826.

Hikaru Takano, Tetsuo Narumi, Nami Ohashi, Akinobu Suzuki, Toshiaki Furuta, Wataru Nomura & Hirokazu Tamamura: Development of the 8-Aza-3-bromo-7-hydroxycoumarin-4-ylmethyl Group as a New Entry of Photolabile Protecting Groups. Tetrahedron, . 2014; 70 (29): 4400-4404.

Jun Yamamoto, Nami Maeda, Chiaki Komiya, Tomohiro Tanaka, Masaya Denda, Koji Ebisuno, Wataru Nomura, Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga & Akira Otaka: Development of a Fluoride-responsive Amide Bond Cleavage Device that is Potentially Applicable to a Traceable Linker. Tetrahedron,. 2014; 70 (34): 5122-5127.

Ma, F.; Liu, S.-Y.; Razani, B.; Arora, N.; Li, B.; Kagechika, H.; Tontonoz, P.; Nunez, V.; Ricote, M.; Cheng, G.: Retinoid X receptor a attenuates host antiviral response by suppressing type I interferon Nature Communication. 2014; 5 5494. ( DOI )

Mori, S.; Takagaki, R.; Fujii, S.; Matsumura, M.; Tanatani, A.; Kagechika, H.: Lipase-catalyzed asymmetric acylation of boron cluster-containing secondary alcohols Tetrahedron Asymmetry. 2014; 25 1505-1512. ( DOI )

Canavan, M.; McCarthy, C.; Ben Larbi, N.; Dowling, J. K.; Collins, L.; O'Sullivan, F.; Hurley, G.; Murphy, C.; Quinlan, A.; Moloney, G.; Darby, T.; MacSharry, J.; Kagechika, H.; Moynagh, P.; Melgar, S.; Loscher, C. E.: Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-kappa Bp50 Innate Immunology. 2014; 20 675-687. ( DOI )

Shiraishi, T.; Saito, T.; Kagechika, H.; Hirano, T.: Development of a novel fluorescent sensor to detect a specific range of pH Tetrahedron Letters. 2014; 55 6784-6786. ( DOI )

Kosuke Tanegashima#, Kohei Tsuji#, Kenji Suzuki, Akira Shigenaga, Akira Otaka, Takahiko Hara (#Equally contributed): Dimeric peptides of the C-terminal region of CXCL14 function as CXCL12 inhibitors. FEBS Lett.. 2013.11; 587 (23): 3770-3775. ( PubMed , DOI )

Kosuke Tanegashima, Kenji Suzuki, Yuki Nakayama, Kohei Tsuji, Akira Shigenaga, Akira Otaka, Takahiko Hara: CXCL14 is a natural inhibitor of the CXCL12-CXCR4 signaling axis. FEBS Lett.. 2013.06; 587 (12): 1731-1735. ( PubMed , DOI )

Effect of Base Molecules on One-dimensional Assembly of Silica Nanospheres Mediated by a Block Copolymer 2013.05; 42 (5): 481-482. ( DOI )

Self-assembly of elastin-mimetic double hydrophobic polypeptides 2013.04; 14 (4): 1028-1034. ( PubMed , DOI )

Ayae Sugawara-Narutaki: Bio-Inspired Synthesis of Polymer–Inorganic Nanocomposite Materials in Mild Aqueous Systems Polym. J.. 2013.03; 45 (3): 269-276. ( DOI )

Facile Synthesis of Well-dispersed Hollow Mesoporous Silica Nanoparticles Using Iron Oxide Nanoparticles as Template 2013.03; 42 (3): 316-317. ( DOI )

Tetsuo Narumi, Haruo Aikawa, Tomohiro Tanaka, Chie Hashimoto, Nami Ohashi, Wataru Nomura, Takuya Kobayakawa, Hikaru Takano, Yuki Hirota, Tsutomu Murakami, Naoki Yamamoto, Hirokazu Tamamura: Low-molecular-weight CXCR4 ligands with variable spacers. ChemMedChem. 2013.01; 8 (1): 118-124. ( PubMed , DOI )

Hierarchical porous silica via solid-phase hydrolysis/polycondensation of cubic siloxane-based molecular units 2013.01; 1 (3): 671-676. ( DOI )

Diol-Linked Microporous Networks of Cubic Siloxane Cages 2013.01; 19 (5): 1700-1705. ( DOI )

Synthesis of ordered photoresponsive azobenzene-siloxane hybrids by self-assembly 2013; 1 (42): 6989-6995. ( DOI )

Philippe Saint-Cricq, Junzheng Wang, Ayae Sugawara-Narutaki, Atsushi Shimojima, Tatsuya Okubo: A New Synthesis of Well-Dispersed, Core–Shell Ag@SiO2 Mesoporous Nanoparticles Using Amino Acid and Sugar J. Mater. Chem. B. 2013; 1 (19): 2451-2454. ( DOI )

Nami Ohashi, Wataru Nomura, Tetsuo Narumi & Hirokazu Tamamura: Peptide-based Ligand Screening and Functional Analysis of Protein Kinase C Biopolymers. 2013; 100 (6): 613-620.

Elastin-based silver-binding proteins with antibacterial capabilities 2013; 8 (4): 567-575. ( DOI )

Tetsuo Narumi, Haruo Aikawa, Tomohiro Tanaka, Chie Hashimoto, Nami Ohashi, Wataru Nomura, Takuya Kobayakawa, Hikaru Takano, Yuki Hirota, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura: Low Molecular Weight CXCR4 Ligands with Variable Spacers. ChemMedChem,. 2013; 8 (1): 118-124.

Tetsuo Narumi, Hiroshi Arai, Kazuhisa Yoshimura, Shigeyoshi Harada, Yuki Hirota, Nami Ohashi, Chie Hashimoto, Wataru Nomura, Shuzo Matsushita & Hirokazu Tamamura: CD4 Mimics as HIV Entry Inhibitors: Lead Optimization Studies of the Aromatic Substituents. Bioorg. Med. Chem.,. 2013; 21 (9): 2518-2526.

Wataru Nomura, Chie Hashimoto, Takaharu Suzuki, Nami Ohashi, Masayuki Fujino, Tsutomu Murakami, Naoki Yamamoto & Hirokazu Tamamura: Multimerized CHR-derived Peptides as HIV-1 Fusion Inhibitors. Bioorg. Med. Chem.,. 2013; 21 (15): 4452-4458.

Chie Hashimoto, Wataru Nomura, Tetsuo Narumi, Masayuki Fujino, Hiroshi Tsutsumi, Masaki Haseyama, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura: Anti-HIV-1 Peptide Derivatives Based on the HIV-1 Co-receptor CXCR4. ChemMedChem,. 2013; 8 (10): 1668-1672.

Wataru Nomura, Haruo Aikawa, Nami Ohashi, Emiko Urano, Mathieu Metifiot, Masayuki Fujino, Kasthuraiah Maddali, Taro Ozaki, Ami Nozue, Tetsuo Narumi, Chie Hashimoto, Tomohiro Tanaka, Yves Pommier, Naoki Yamamoto, Jun Komano, Tsutomu Murakami & Hirokazu Tamamura: Cell-Permeable Stapled Peptides Based on HIV-1 Integrase Inhibitors Derived from HIV-1 Gene Product. ACS Chem. Biol.,. 2013; 8 (10): 2235-2244.

Hiroyuki Otsuki, Takayuki Hishiki, Tomoyuki Miura, Chie Hashimoto, Tetsuo Narumi, Hirokazu Tamamura, Kazuhisa Yoshimura, Shuzo Matsushita & Tatsuhiko Igarashi: Generation of a Replication-competent Simian–human Immunodeficiency Virus, the Neutralisation Sensitivity of Which can be Enhanced in the Presence of a Small Molecule CD4 Mimic. J. Gen. Virol.,. 2013; 94 (12): 2710-2716.

Chie Hashimoto, Wataru Nomura, Tetsuo Narumi, Masayuki Fujino, Toru Nakahara, Naoki Yamamoto, Tsutomu Murakami & Hirokazu Tamamura: CXCR4-derived Synthetic Peptides Inducing Anti-HIV-1 Antibodies. Bioorg. Med. Chem.,. 2013; 21 (22): 6878-6885.

Chie Hashimoto, Tetsuo Narumi, Hiroyuki Otsuki, Yuki Hirota, Hiroshi Arai, Kazuhisa Yoshimura, Shigeyoshi Harada, Nami Ohashi, Wataru Nomura, Tomoyuki Miura, Tatsuhiko Igarashi, Shuzo Matsushita & Hirokazu Tamamura: A CD4 Mimic as an HIV Entry Inhibitor: Pharmacokinetics. Bioorg. Med. Chem.,. 2013; 21 (24): 7884-7889.

Biphasic synthesis of colloidal mesoporous silica nanoparticles using primary amine catalysts 2012.11; 385 (1): 41-47. ( DOI )

One-Dimensional Assembly of Silica Nanospheres: Effects of Nonionic Block Copolymers 2012.09; 28 (37): 13181-13188. ( DOI )

Tetsuo Narumi, Takuya Kobayakawa, Haruo Aikawa, Shunsuke Seike, Hirokazu Tamamura: Stereoselective formation of trisubstituted (Z)-chloroalkenes adjacent to a tertiary carbon stereogenic center by organocuprate-mediated reduction/alkylation. Organic Letters. 2012.09; 14 (17): 4490-4493. ( PubMed , DOI )

Ken Sakamoto, Kohei Sato, Akira Shigenaga, Kohei Tsuji, Shugo Tsuda, Hajime Hibino, Yuji Nishiuchi, Akira Otaka: Synthetic procedure for N-Fmoc amino acyl-N-sulfanylethylaniline linker as crypto-peptide thioester precursor with application to native chemical ligation. J. Org. Chem.. 2012.08; 77 (16): 6948-6958. ( PubMed , DOI )

Philippe Saint-Cricq, Yoshihiro Kamimura, Keiji Itabashi, Ayae Sugawara-Narutaki, Atsushi Shimojima, Tatsuya Okubo: Antibacterial Activity of Silver-Loaded “Green Zeolites” Eur. J. Inorg. Chem.. 2012.07; 21 (21): 3398-3402. ( DOI )

Narumi T, Tanaka T, Hashimoto C, Nomura W, Aikawa H, Sohma A, Itotani K, Kawamata M, Murakami T, Yamamoto N, Tamamura H: Pharmacophore-based small molecule CXCR4 ligands. Bioorg Med Chem Lett. 2012.06; 22 (12): 4169-4172. ( PubMed , DOI )

Hashimoto C, Nomura W, Ohya A, Urano E, Miyauchi K, Narumi T, Aikawa H, Komano JA, Yamamoto N, Tamamura H: Evaluation of a synthetic C34 trimer of HIV-1 gp41 as AIDS vaccines. Bioorg Med Chem. 2012.05; 20 (10): 3287-3291. ( PubMed , DOI )

Narumi T, Komoriya M, Hashimoto C, Wu H, Nomura W, Suzuki S, Tanaka T, Chiba J, Yamamoto N, Murakami T, Tamamura H: Conjugation of cell-penetrating peptides leads to identification of anti-HIV peptides from matrix proteins. Bioorg Med Chem. 2012.02; 20 (4): 1468-1474. ( PubMed , DOI )

Nomura W, Hashimoto C, Ohya A, Miyauchi K, Urano E, Tanaka T, Narumi T, Nakahara T, Komano JA, Yamamoto N, Tamamura H: A synthetic C34 trimer of HIV-1 gp41 shows significant increase in inhibition potency. ChemMedChem. 2012.02; 7 (2): 205-208. ( PubMed , DOI )

Nomura W, Masuda A, Ohba K, Urabe A, Ito N, Ryo A, Yamamoto N, Tamamura H: Effects of DNA binding of the zinc finger and linkers for domain fusion on the catalytic activity of sequence-specific chimeric recombinases determined by a facile fluorescent system. Biochemistry. 2012.02; 51 (7): 1510-1517. ( PubMed , DOI )

Chain-like nanostructures from anisotropic self-assembly of semiconducting metal oxide nanoparticles with a block copolymer 2012; 48 (90): 11115-11117. ( DOI )

Tetsuo Narumi, Takuya Kobayakawa, Haruo Aikawa, Shunsuke Seike & Hirokazu Tamamura: Stereoselective Formation of Trisubstituted (Z)-Chloroalkenes Adjacent to a Tertiary Carbon Stereogenic Center by Organocuprate-Mediated Reduction/Alkylation. Org. Lett., 14(17), 4490-4493. 2012; 14 (17): 4490-4493.

Narumi T, Arai H, Yoshimura K, Harada S, Nomura W, Matsushita S, Tamamura H: Small molecular CD4 mimics as HIV entry inhibitors. Bioorg Med Chem. 2011.11; 19 (22): 6735-6742. ( PubMed , DOI )

Hashimoto C, Tanaka T, Narumi T, Nomura W, Tamamura H: The successes and failures of HIV drug discovery. Expert Opin Drug Discov. 2011.10; 6 (10): 1067-1090. ( PubMed , DOI )

Porous Siloxane-Organic Hybrid with Ultrahigh Surface Area through Simultaneous Polymerization-Destruction of Functionalized Cubic Siloxane Cages 2011.09; 133 (35): 13832-13835. ( DOI )

Kohei Sato, Akira Shigenaga, Kohei Tsuji, Shugo Tsuda, Yoshitake Sumikawa, Ken Sakamoto, Akira Otaka: N-sulfanylethylanilide peptide as a crypto-thioester peptide. Chembiochem. 2011.08; 12 (12): 1840-1844. ( PubMed , DOI )

Kohei Tsuji, Akira Shigenaga, Yoshitake Sumikawa, Kosuke Tanegashima, Kohei Sato, Keisuke Aihara, Takahiko Hara, Akira Otaka: Application of N-C- or C-N-directed sequential native chemical ligation to the preparation of CXCL14 analogs and their biological evaluation. Bioorg. Med. Chem.. 2011.07; 19 (13): 4014-4020. ( PubMed , DOI )

Yamada M, Kubo H, Kobayashi S, Ishizawa K, He M, Suzuki T, Fujino N, Kunishima H, Hatta M, Nishimaki K, Aoyagi T, Tokuda K, Kitagawa M, Yano H, Tamamura H, Fujii N, Kaku M: The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury. Cell Mol Immunol. 2011.07; 8 (4): 305-314. ( PubMed , DOI )

Xu C, Liu J, Chen L, Liang S, Fujii N, Tamamura H, Xiong H: HIV-1 gp120 enhances outward potassium current via CXCR4 and cAMP-dependent protein kinase A signaling in cultured rat microglia. Glia. 2011.06; 59 (6): 997-1007. ( PubMed , DOI )

Nomura W, Ohashi N, Okuda Y, Narumi T, Ikura T, Ito N, Tamamura H: Fluorescence-quenching screening of protein kinase C ligands with an environmentally sensitive fluorophore. Bioconjug Chem. 2011.05; 22 (5): 923-930. ( PubMed , DOI )

Tanaka T, Narumi T, Ozaki T, Sohma A, Ohashi N, Hashimoto C, Itotani K, Nomura W, Murakami T, Yamamoto N, Tamamura H: Azamacrocyclic metal complexes as CXCR4 antagonists. ChemMedChem. 2011.05; 6 (5): 834-839. ( PubMed , DOI )

Two-Phase Synthesis of Monodisperse Silica Nanospheres with Amines or Ammonia Catalyst and Their Controlled Self-Assembly 2011.05; 3 (5): 1538-1544. ( DOI )

Nomura W, Narumi T, Ohashi N, Serizawa Y, Lewin NE, Blumberg PM, Furuta T, Tamamura H: Synthetic caged DAG-lactones for photochemically controlled activation of protein kinase C. Chembiochem. 2011.03; 12 (4): 535-539. ( PubMed , DOI )

Tsutsumi H, Abe S, Mino T, Nomura W, Tamamura H: Intense blue fluorescence in a leucine zipper assembly. Chembiochem. 2011.03; 12 (5): 691-694. ( PubMed , DOI )

Crystallization Behavior of Zeolite Beta in OSDA-Free, Seed-Assisted Synthesis 2011.01; 115 (3): 744-750. ( DOI )

Ohashi N, Nomura W, Narumi T, Lewin NE, Itotani K, Blumberg PM, Tamamura H: Fluorescent-responsive synthetic C1b domains of protein kinase Cdelta as reporters of specific high-affinity ligand binding. Bioconjug Chem. 2011.01; 22 (1): 82-87. ( PubMed , DOI )

Preparation of Anisotropic Silica Nanoparticles via Controlled Assembly of Presynthesized Spherical Seeds 2010.12; 26 (23): 18491-18498. ( DOI )

Tanaka T, Nomura W, Narumi T, Masuda A, Tamamura H: Bivalent ligands of CXCR4 with rigid linkers for elucidation of the dimerization state in cells. J Am Chem Soc. 2010.11; 132 (45): 15899-15901. ( PubMed , DOI )

Supported and Free-Standing Sulfonic Acid Functionalized Mesostructured Silica Films with High Proton Conductivity 2010.09; 25 (25): 3993-3999. ( DOI )

Microporous Hybrid Polymer with a Certain Crystallinity Built from Functionalized Cubic Siloxane Cages as a Singular Building Unit 2010.09; 22 (17): 4841-4843. ( DOI )

Yoshimura K, Harada S, Shibata J, Hatada M, Yamada Y, Ochiai C, Tamamura H, Matsushita S: Enhanced exposure of human immunodeficiency virus type 1 primary isolate neutralization epitopes through binding of CD4 mimetic compounds. J Virol. 2010.08; 84 (15): 7558-7568. ( PubMed , DOI )

Suzuki S, Urano E, Hashimoto C, Tsutsumi H, Nakahara T, Tanaka T, Nakanishi Y, Maddali K, Han Y, Hamatake M, Miyauchi K, Pommier Y, Beutler JA, Sugiura W, Fuji H, Hoshino T, Itotani K, Nomura W, Narumi T, Yamamoto N, Komano JA, Tamamura H: Peptide HIV-1 Integrase Inhibitors from HIV-1 Gene Products. J Med Chem. 2010.07; 53 (14): 5356-5360. ( PubMed , DOI )

Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H: Peptidic HIV integrase inhibitors derived from HIV gene products: Structure-activity relationship studies. Bioorg Med Chem. 2010.07; 18 6771-6775. ( PubMed , DOI )

Melchionna R, Di Carlo A, De Mori R, Cappuzzello C, Barberi L, Musaro A, Cencioni C, Fujii N, Tamamura H, Crescenzi M, Capogrossi MC, Napolitano M, Germani A: Induction of myogenic differentiation by SDF-1 via CXCR4 and CXCR7 receptors. Muscle Nerve. 2010.06; 41 (6): 828-835. ( PubMed , DOI )

Nakahara T, Nomura W, Ohba K, Ohya A, Tanaka T, Hashimoto C, Narumi T, Murakami T, Yamamoto N, Tamamura H: Remodeling of dynamic structures of HIV-1 envelope proteins leads to synthetic antigen molecules inducing neutralizing antibodies. Bioconjug Chem. 2010.04; 21 (4): 709-714. ( PubMed , DOI )

Aoki T, Shimizu S, Urano E, Futahashi Y, Hamatake M, Tamamura H, Terashima K, Murakami T, Yamamoto N, Komano J: Improvement of lentiviral vector-mediated gene transduction by genetic engineering of the structural protein Pr55(Gag). Gene Ther. 2010.04; 17 (9): 1124-1133. ( PubMed , DOI )

Tri(quaternary ammonium) Surfactant with a Benzene Core as a Novel Template for Synthesis of Ordered Porous Silica 2010.03; 39 (3): 236-237. ( DOI )

Yamada Y, Ochiai C, Yoshimura K, Tanaka T, Ohashi N, Narumi T, Nomura W, Harada S, Matsushita S, Tamamura H: CD4 mimics targeting the mechanism of HIV entry. Bioorg Med Chem Lett. 2010.01; 20 (1): 354-358. ( PubMed , DOI )

Narumi T, Ochiai C, Yoshimura K, Harada S, Tanaka T, Nomura W, Arai H, Ozaki T, Ohashi N, Matsushita S, Tamamura H: CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist. Bioorg Med Chem Lett. 2010; 20 5853-5858. ( PubMed , DOI )

Nomura W, Mino T, Narumi T, Ohashi N, Masuda A, Hashimoto C, Tsutsumi H, Tamamura H: Development of crosslink-type tag-probe pairs for fluorescent imaging of proteins. Biopolymers. 2010; 94 843-852. ( PubMed , DOI )

Hybrid Porous Materials with High Surface Area Derived from Bromophenylethenyl-Functionalized Cubic Siloxane-Based Building Units 2010; 16 (20): 6006-6014. ( DOI )

Generation of Surface-Bound Multicomponent Protein Gradients 2009.11; 10 (16): 2617-2619. ( DOI )

One-Dimensional Assembly of Silica Nanospheres Mediated by Block Copolymer in Liquid Phase 2009.11; 131 (45): 16344-+. ( DOI )

Ohashi N, Nomura W, Kato M, Narumi T, Lewin NE, Blumberg PM, Tamamura H: Synthesis of protein kinase Cdelta C1b domain by native chemical ligation methodology and characterization of its folding and ligand binding. J Pept Sci. 2009.10; 15 (10): 642-646. ( PubMed , DOI )

Tanaka T, Nomura W, Narumi T, Esaka A, Oishi S, Ohashi N, Itotani K, Evans BJ, Wang ZX, Peiper SC, Fujii N, Tamamura H: Structure-activity relationship study on artificial CXCR4 ligands possessing the cyclic pentapeptide scaffold: the exploration of amino acid residues of pentapeptides by substitutions of several aromatic amino acids. Org Biomol Chem. 2009.09; 7 (18): 3805-3809. ( PubMed , DOI )

Hybrid Nanoapatite by Polysaccharide Nanogel-templated Mineralization 2009.03; 24 (2): 151-168. ( DOI )

Nanogel-Calcium Phosphate Hybrid Nanoparticles with Negative or Positive Charges for Potential Biomedical Applications 2009.03; 82 (3): 416-418. ( DOI )

Inaba Y, Yoshimoto N, Sakamaki Y, Nakabayashi M, Ikura T, Tamamura H, Ito N, Shimizu M, Yamamoto K: A New Class of Vitamin D Analogues that Induce Structural Rearrangement of the Ligand-Binding Pocket of the Receptor. J Med Chem. 2009.02; ( PubMed , DOI )

Three-Dimensional Relief Structures of CaCO3 Crystal Assemblies Formed by Spontaneous Two-Step Crystal Growth on a Polymer Thin Film 2009.01; 9 (1): 622-625. ( DOI )

Mizukoshi F, Baba K, Goto-Koshino Y, Setoguchi-Mukai A, Fujino Y, Ohno K, Tamamura H, Oishi S, Fujii N, Tsujimoto H: Inhibitory effect of newly developed CXC-chemokine receptor 4 antagonists on the infection with feline immunodeficiency virus. J Vet Med Sci. 2009.01; 71 (1): 121-124. ( PubMed )

Calcium Carbonate/Polymer Thin-Film Hybrids: Induction of the Formation of Patterned Aragonite Crystals by Thermal Treatment of a Polymer Matrix 2009; 41 (7): 522-523. ( DOI )

Tsutsumi H, Nomura W, Abe S, Mino T, Masuda A, Ohashi N, Tanaka T, Ohba K, Yamamoto N, Akiyoshi K, Tamamura H: Fluorogenically active leucine zipper peptides as tag-probe pairs for protein imaging in living cells. Angew Chem Int Ed Engl. 2009; 48 (48): 9164-9166. ( PubMed , DOI )

Tamamura H, Tanaka T, Tsutsumi H, Ohashi N, Hiramatsu K, Araki T, Ojida A, Hamachi I, Wang Z, Peiper SC, Trent JO, Ueda S, Oishi S, Fujii N: Development of chemokine receptor CXCR4 antagonists using bio-mimetic strategy. Adv Exp Med Biol. 2009; 611 145-146. ( PubMed )

Rino R. Mukti, Hirotomo Hirahara, Ayae Sugawara, Atsushi Shimojima, Tatsuya Okubo: Direct Hydrothermal Synthesis of Hierarchically Porous Siliceous Zeolite by Using Alkoxysilylated Nonionic Surfactant Langmuir. 2009; 26 2731-2735.

Tamamura H, Tanaka T, Tsutsumi H, Nemoto K, Mizokami S, Ohashi N, Oishi S, Fujii N: Stereoselective synthesis of peptidomimetics based on acid-catalyzed ring-opening of beta-aziridinyl-alpha,beta-enoates. Adv Exp Med Biol. 2009; 611 149-150. ( PubMed )

Tanaka T, Tsutsumi H, Nomura W, Tanabe Y, Ohashi N, Esaka A, Ochiai C, Sato J, Itotani K, Murakami T, Ohba K, Yamamoto N, Fujii N, Tamamura H: Structure-activity relationship study of CXCR4 antagonists bearing the cyclic pentapeptide scaffold: identification of the new pharmacophore. Org Biomol Chem. 2008.12; 6 (23): 4374-4377. ( PubMed , DOI )

Effects of Peptides on CaCO3 Crystallization: Mineralization Properties of an Acidic Peptide Isolated from Exoskeleton of Crayfish and Its Derivatives 2008.11; 8 (11): 4062-4065. ( DOI )

Nomura W, Tanabe Y, Tsutsumi H, Tanaka T, Ohba K, Yamamoto N, Tamamura H: Fluorophore labeling enables imaging and evaluation of specific CXCR4-ligand interaction at the cell membrane for fluorescence-based screening. Bioconjug Chem. 2008.09; 19 (9): 1917-1920. ( PubMed , DOI )

Nakata H, Steinberg SM, Koh Y, Maeda K, Takaoka Y, Tamamura H, Fujii N, Mitsuya H: Potent synergistic anti-human immunodeficiency virus (HIV) effects using combinations of the CCR5 inhibitor aplaviroc with other anti-HIV drugs. Antimicrob Agents Chemother. 2008.06; 52 (6): 2111-2119. ( PubMed , DOI )

Driessen WH, Fujii N, Tamamura H, Sullivan SM: Development of peptide-targeted lipoplexes to CXCR4-expressing rat glioma cells and rat proliferating endothelial cells. Mol Ther. 2008.03; 16 (3): 516-524. ( PubMed , DOI )

Hirokazu Tamamura, Hiroshi Tsutsumi, Wataru Nomura, Tomohiro Tanaka & Nobutaka Fujii: A Future Perspective on the Development of Chemokine Receptor CXCR4 Antagonists. Expert Opin. Drug Discovery. 2008; 3 (10): 1150-1166.

Kasiyanov A, Fujii N, Tamamura H, Xiong H: Modulation of network-driven, GABA-mediated giant depolarizing potentials by SDF-1alpha in the developing hippocampus. Dev Neurosci. 2008; 30 (4): 285-292. ( PubMed , DOI )

Tamamura H, Tsutsumi H, Nomura W, Fujii N: Exploratory studies on development of the chemokine receptor CXCR4 antagonists toward downsizing. Perspect Medicin Chem. 2008; 2 1-9. ( PubMed )

Kabashima K, Sugita K, Shiraishi N, Tamamura H, Fujii N, Tokura Y: CXCR4 engagement promotes dendritic cell survival and maturation. Biochem Biophys Res Commun. 2007.10; 361 (4): 1012-1016. ( PubMed , DOI )

Kabashima K, Shiraishi N, Sugita K, Mori T, Onoue A, Kobayashi M, Sakabe J, Yoshiki R, Tamamura H, Fujii N, Inaba K, Tokura Y: CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells. Am J Pathol. 2007.10; 171 (4): 1249-1257. ( PubMed , DOI )

Kubonishi S, Kikuchi T, Yamaguchi S, Tamamura H, Fujii N, Watanabe T, Arenzana-Seisdedos F, Ikeda K, Matsui T, Tanimoto M, Katayama Y: Rapid hematopoietic progenitor mobilization by sulfated colominic acid. Biochem Biophys Res Commun. 2007.04; 355 (4): 970-975. ( PubMed , DOI )

Berchiche YA, Chow KY, Lagane B, Leduc M, Percherancier Y, Fujii N, Tamamura H, Bachelerie F, Heveker N: Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and G(alpha)(i) activation. J Biol Chem. 2007.02; 282 (8): 5111-5115. ( PubMed , DOI )

Ueda S, Oishi S, Wang ZX, Araki T, Tamamura H, Cluzeau J, Ohno H, Kusano S, Nakashima H, Trent JO, Peiper SC, Fujii N: Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities. J Med Chem. 2007.01; 50 (2): 192-198. ( PubMed , DOI )

Possible molecular evolution of biomembranes: from single-chain to double-chain lipids 2007; 4 (5): 837-848.

Tsutsumi H, Tanaka T, Ohashi N, Masuno H, Tamamura H, Hiramatsu K, Araki T, Ueda S, Oishi S, Fujii N: Therapeutic potential of the chemokine receptor CXCR4 antagonists as multifunctional agents. Biopolymers. 2007; 88 (2): 279-289. ( PubMed , DOI )

Tamamura H, Tsutsumi H, Masuno H, Fujii N: Development of low molecular weight CXCR4 antagonists by exploratory structural tuning of cyclic tetra- and pentapeptide-scaffolds towards the treatment of HIV infection, cancer metastasis and rheumatoid arthritis. Curr Med Chem. 2007; 14 (1): 93-102. ( PubMed )

Hiroshi Tsutsumi, Hirokazu Tamamura & Nobutaka Fujii: Inhibitors of the Chemokine Receptor CXCR4. Chemotherapy of AIDS, Metastatic Cancer, Leukemia and Rheumatoid Arthritis. Lett. Drug Design Discovery. 2007; 4 20-26.

Hirokazu Tamamura, Tomohiro Tanaka, Hiroshi Tsutsumi, Koji Nemoto, Satoko Mizokami, Nami Ohashi, Shinya Oishi & Nobutaka Fujii: Versatile Use of Acid-catalyzed Ring-opening of β-Aziridinyl-α,β-enoates to Stereoselective Synthesis of Peptidomimetics. Tetrahedron. 2007; 63 9243-9254.

Tamamura H, Tsutsumi H, Fujii N: The chemokine receptor CXCR4 as a therapeutic target for several diseases. Mini Rev Med Chem. 2006.09; 6 (9): 989-995. ( PubMed )

POLY 422-Nanogel-inorganic hybrid: Synthesis of polysaccharide-calcium phosphate nanomaterials 2006.09; 232

Assembled structures of nanocrystals in polymer/calcium carbonate thin-film composites formed by the cooperation of chitosan and poly(aspartate) 2006.09; 44 (17): 5153-5160. ( DOI )

Tamamura H, Tsutsumi H, Masuno H, Mizokami S, Hiramatsu K, Wang Z, Trent JO, Nakashima H, Yamamoto N, Peiper SC, Fujii N: Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs. Org Biomol Chem. 2006.06; 4 (12): 2354-2357. ( PubMed , DOI )

Tamamura H, Ojida A, Ogawa T, Tsutsumi H, Masuno H, Nakashima H, Yamamoto N, Hamachi I, Fujii N: Identification of a new class of low molecular weight antagonists against the chemokine receptor CXCR4 having the dipicolylamine-zinc(II) complex structure. J Med Chem. 2006.06; 49 (11): 3412-3415. ( PubMed , DOI )

Menu E, Asosingh K, Indraccolo S, De Raeve H, Van Riet I, Van Valckenborgh E, Vande Broek I, Fujii N, Tamamura H, Van Camp B, Vanderkerken K: The involvement of stromal derived factor 1alpha in homing and progression of multiple myeloma in the 5TMM model. Haematologica. 2006.05; 91 (5): 605-612. ( PubMed )

Hanaoka H, Mukai T, Tamamura H, Mori T, Ishino S, Ogawa K, Iida Y, Doi R, Fujii N, Saji H: Development of a 111In-labeled peptide derivative targeting a chemokine receptor, CXCR4, for imaging tumors. Nucl Med Biol. 2006.05; 33 (4): 489-494. ( PubMed , DOI )

Niida A, Tanigaki H, Inokuchi E, Sasaki Y, Oishi S, Ohno H, Tamamura H, Wang Z, Peiper SC, Kitaura K, Otaka A, Fujii N: Stereoselective synthesis of 3,6-disubstituted-3,6-dihydropyridin-2-ones as potential diketopiperazine mimetics using organocopper-mediated anti-SN2' reactions and their use in the preparation of low-molecule CXCR4 antagonists. J Org Chem. 2006.05; 71 (10): 3942-3951. ( PubMed , DOI )

Self-organization of patterned CaCO3/polymer composite films: Tuning of their morphologies by the change of molecular weights of acidic polymers 2006.03; 35 (3): 310-311. ( DOI )

Kasyanov A, Tamamura H, Fujii N, Xiong H: HIV-1 gp120 enhances giant depolarizing potentials via chemokine receptor CXCR4 in neonatal rat hippocampus. Eur J Neurosci. 2006.03; 23 (5): 1120-1128. ( PubMed , DOI )

Nanogel-templated mineralization: Polymer-calcium phosphate hybrid nanomaterials 2006.03; 27 (6): 441-446. ( DOI )

Tamamura H, Tsutsumi H: Specific probes for chemokine receptors. Chem Biol. 2006.01; 13 (1): 8-10. ( PubMed , DOI )

Niida A, Wang Z, Tomita K, Oishi S, Tamamura H, Otaka A, Navenot JM, Broach JR, Peiper SC, Fujii N: Design and synthesis of downsized metastin (45-54) analogs with maintenance of high GPR54 agonistic activity. Bioorg Med Chem Lett. 2006.01; 16 (1): 134-137. ( PubMed , DOI )

Shinya Oishi, Kazuhide Miyamoto, Ayumu Niida, Mikio Yamamoto, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka, Yoshihiro Kuroda, Akira Asai & Nobutaka Fujii: Application of Tri- and Tetrasubstituted Alkene Dipeptide Mimetics to Conformational Studies of Cyclic RGD Peptides. Tetrahedron. 2006; 62 1416-1424.

Self-organization of oriented calcium carbonate/polymer composites: Effects of a matrix peptide isolated from the exoskeleton of a crayfish 2006; 45 (18): 2876-2879. ( DOI )

Hirokazu Tamamura & Hiroshi Tsutsumi: Specific Probes for Chemokine Receptors Chem. Biol.. 2006; 13 8-10.

Tamamura H, Esaka A, Ogawa T, Araki T, Ueda S, Wang Z, Trent JO, Tsutsumi H, Masuno H, Nakashima H, Yamamoto N, Peiper SC, Otaka A, Fujii N: Structure-activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds. Org Biomol Chem. 2005.12; 3 (24): 4392-4394. ( PubMed , DOI )

Tamamura H, Fujii N: The therapeutic potential of CXCR4 antagonists in the treatment of HIV infection, cancer metastasis and rheumatoid arthritis. Expert Opin Ther Targets. 2005.12; 9 (6): 1267-1282. ( PubMed , DOI )

Ueda S, Fujita M, Tamamura H, Fujii N, Otaka A: Photolabile protection for one-pot sequential native chemical ligation. Chembiochem. 2005.11; 6 (11): 1983-1986. ( PubMed , DOI )

Tamamura H, Otaka A, Fujii N: Development of anti-HIV agents targeting dynamic supramolecular mechanism: entry and fusion inhibitors based on CXCR4/CCR5 antagonists and gp41-C34-remodeling peptides. Curr HIV Res. 2005.10; 3 (4): 289-301. ( PubMed )

Burger M, Hartmann T, Krome M, Rawluk J, Tamamura H, Fujii N, Kipps TJ, Burger JA: Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Blood. 2005.09; 106 (5): 1824-1830. ( PubMed , DOI )

Tamamura H, Araki T, Ueda S, Wang Z, Oishi S, Esaka A, Trent JO, Nakashima H, Yamamoto N, Peiper SC, Otaka A, Fujii N: Identification of novel low molecular weight CXCR4 antagonists by structural tuning of cyclic tetrapeptide scaffolds. J Med Chem. 2005.05; 48 (9): 3280-3289. ( PubMed , DOI )

Percherancier Y, Berchiche YA, Slight I, Volkmer-Engert R, Tamamura H, Fujii N, Bouvier M, Heveker N: Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers. J Biol Chem. 2005.03; 280 (11): 9895-9903. ( PubMed , DOI )

Zannettino AC, Farrugia AN, Kortesidis A, Manavis J, To LB, Martin SK, Diamond P, Tamamura H, Lapidot T, Fujii N, Gronthos S: Elevated serum levels of stromal-derived factor-1alpha are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients. Cancer Res. 2005.03; 65 (5): 1700-1709. ( PubMed , DOI )

Piovan E, Tosello V, Indraccolo S, Cabrelle A, Baesso I, Trentin L, Zamarchi R, Tamamura H, Fujii N, Semenzato G, Chieco-Bianchi L, Amadori A: Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation. Blood. 2005.02; 105 (3): 931-939. ( PubMed , DOI )

Nameki D, Kodama E, Ikeuchi M, Mabuchi N, Otaka A, Tamamura H, Ohno M, Fujii N, Matsuoka M: Mutations conferring resistance to human immunodeficiency virus type 1 fusion inhibitors are restricted by gp41 and Rev-responsive element functions. J Virol. 2005.01; 79 (2): 764-770. ( PubMed , DOI )

Tamamura H, Hiramatsu K, Ueda S, Wang Z, Kusano S, Terakubo S, Trent JO, Peiper SC, Yamamoto N, Nakashima H, Otaka A, Fujii N: Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131. J Med Chem. 2005.01; 48 (2): 380-391. ( PubMed , DOI )

Ayumu Niida, Shinya Oishi, Yoshikazu Sasaki, Makiko Mizumoto, Hirokazu Tamamura, Nobutaka Fujii & Akira Otaka: Facile Access to (Z)-Alkene-containing Diketopiperazine Mimetics Utilizing Organocopper-mediated Anti-SN2' Reactions. Tetrahedron Lett.. 2005; 46 4183-4186.

Margitta Retz, Sachdev S. Sidhu, Jan Lehmann, Hirokazu Tamamura, Nobutaka Fujii & Carol Basbaum: New HIV-Drug Inhibits in Vitro Bladder Cancer Migration and Invasion Eur. Urol.. 2005; 48 (6): 1025-1030.

Jayendra B. Bhonsle, Zi-xuan Wang, Hirokazu Tamamura, Nobutaka Fujii, Stephen C. Peiper & John O. Trent: A Simple, Automated Quasi-4D-QSAR, Quasi-multi Way PLS Approach to Develop Highly Predictive QSAR Models for Highly Flexible CXCR4 Inhibitor Cyclic Peptide Ligands Using Scripted Common Molecular Modeling Tools. QSAR Comb. Sci.. 2005; 24 (5): 620-630.

Allen CD, Ansel KM, Low C, Lesley R, Tamamura H, Fujii N, Cyster JG: Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat Immunol. 2004.09; 5 (9): 943-952. ( PubMed , DOI )

Tamamura H, Sigano DM, Lewin NE, Peach ML, Nicklaus MC, Blumberg PM, Marquez VE: Conformationally constrained analogues of diacylglycerol (DAG). 23. Hydrophobic ligand-protein interactions versus ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C). J Med Chem. 2004.09; 47 (20): 4858-4864. ( PubMed , DOI )

Otaka A, Ueda S, Tomita K, Yano Y, Tamamura H, Matsuzaki K, Fujii N: Facile synthesis of membrane-embedded peptides utilizing lipid bilayer-assisted chemical ligation. Chem Commun (Camb). 2004.08; (15): 1722-1723. ( PubMed , DOI )

Tamamura H, Fujisawa M, Hiramatsu K, Mizumoto M, Nakashima H, Yamamoto N, Otaka A, Fujii N: Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent. FEBS Lett. 2004.07; 569 (1-3): 99-104. ( PubMed , DOI )

Yamamoto N, Yang R, Yoshinaka Y, Amari S, Nakano T, Cinatl J, Rabenau H, Doerr HW, Hunsmann G, Otaka A, Tamamura H, Fujii N, Yamamoto N: HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus. Biochem Biophys Res Commun. 2004.06; 318 (3): 719-725. ( PubMed , DOI )

Tamamura H, Fujii N: Two orthogonal approaches to overcome multi-drug resistant HIV-1s: development of protease inhibitors and entry inhibitors based on CXCR4 antagonists. Curr Drug Targets Infect Disord. 2004.06; 4 (2): 103-110. ( PubMed )

Peng H, Huang Y, Rose J, Erichsen D, Herek S, Fujii N, Tamamura H, Zheng J: Stromal cell-derived factor 1-mediated CXCR4 signaling in rat and human cortical neural progenitor cells. J Neurosci Res. 2004.04; 76 (1): 35-50. ( PubMed , DOI )

Tamamura H, Mizumoto M, Hiramatsu K, Kusano S, Terakubo S, Yamamoto N, Trent JO, Wang Z, Peiper SC, Nakashima H, Otaka A, Fujii N: Topochemical exploration of potent compounds using retro-enantiomer libraries of cyclic pentapeptides. Org Biomol Chem. 2004.04; 2 (8): 1255-1257. ( PubMed , DOI )

Otaka A, Watanabe J, Yukimasa A, Sasaki Y, Watanabe H, Kinoshita T, Oishi S, Tamamura H, Fujii N: SmI2-mediated reduction of gamma,gamma-difluoro-alpha,beta-enoates with application to the synthesis of functionalized (Z)-fluoroalkene-type dipeptide isosteres. J Org Chem. 2004.03; 69 (5): 1634-1645. ( PubMed , DOI )

Mori T, Doi R, Koizumi M, Toyoda E, Ito D, Kami K, Masui T, Fujimoto K, Tamamura H, Hiramatsu K, Fujii N, Imamura M: CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer. Mol Cancer Ther. 2004.01; 3 (1): 29-37. ( PubMed )

Tamamura H, Sigano DM, Lewin NE, Blumberg PM, Marquez VE: Conformationally constrained analogues of diacylglycerol. 20. The search for an elusive binding site on protein kinase C through relocation of the carbonyl pharmacophore along the sn-1 side chain of 1,2-diacylglycerol lactones. J Med Chem. 2004.01; 47 (3): 644-655. ( PubMed , DOI )

Calcium carbonate/polymer composites: polymorph control for aragonite 2004; 11 (4): 287-295.

Mitsuko Takenaga, Hirokazu Tamamura, Kenichi Hiramatsu, Natsumi Nakamura, Yoko Yamaguchi, Aki Kitagawa, Shinichi Kawai, Hideki Nakashima, Nobutaka Fujii & Rie Igarashi: A Single Treatment with Microcapsules Containing a CXCR4 Antagonist Suppresses Pulmonary Metastasis of Murine Melanoma. Biochem. Biophys. Res. Commun.. 2004; 320 (1): 226-232.

Trent JO, Wang ZX, Murray JL, Shao W, Tamamura H, Fujii N, Peiper SC: Lipid bilayer simulations of CXCR4 with inverse agonists and weak partial agonists. J Biol Chem. 2003.11; 278 (47): 47136-47144. ( PubMed , DOI )

Tamamura H, Hiramatsu K, Mizumoto M, Ueda S, Kusano S, Terakubo S, Akamatsu M, Yamamoto N, Trent JO, Wang Z, Peiper SC, Nakashima H, Otaka A, Fujii N: Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists. Org Biomol Chem. 2003.11; 1 (21): 3663-3669. ( PubMed )

Tamamura H, Hiramatsu K, Kusano S, Terakubo S, Yamamoto N, Trent JO, Wang Z, Peiper SC, Nakashima H, Otaka A, Fujii N: Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives. Org Biomol Chem. 2003.11; 1 (21): 3656-3662. ( PubMed )

Oonuma T, Morimatsu M, Nakagawa T, Uyama R, Sasaki N, Nakaichi M, Tamamura H, Fujii N, Hashimoto S, Yamamura H, Syuto B: Role of CXCR4 and SDF-1 in mammary tumor metastasis in the cat. J Vet Med Sci. 2003.10; 65 (10): 1069-1073. ( PubMed )

Tamamura H, Hori A, Kanzaki N, Hiramatsu K, Mizumoto M, Nakashima H, Yamamoto N, Otaka A, Fujii N: T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer. FEBS Lett. 2003.08; 550 (1-3): 79-83. ( PubMed )

Otaka A, Yukimasa A, Watanabe J, Sasaki Y, Oishi S, Tamamura H, Fujii N: Application of samarium diiodide (SmI2)-induced reduction of gamma-acetoxy-alpha,beta-enoates with alpha-specific kinetic electrophilic trapping for the synthesis of amino acid derivatives. Chem Commun (Camb). 2003.08; (15): 1834-1835. ( PubMed )

Template effect of crystalline poly(vinyl alcohol) for selective formation of aragonite and vaterite CaCO3 thin films 2003.08; 36 (17): 6449-6452. ( DOI )

Tamamura H, Kato T, Otaka A, Fujii N: Synthesis of potent beta-secretase inhibitors containing a hydroxyethylamine dipeptide isostere and their structure-activity relationship studies. Org Biomol Chem. 2003.07; 1 (14): 2468-2473. ( PubMed )

Fujii N, Oishi S, Hiramatsu K, Araki T, Ueda S, Tamamura H, Otaka A, Kusano S, Terakubo S, Nakashima H, Broach JA, Trent JO, Wang ZX, Peiper SC: Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries. Angew Chem Int Ed Engl. 2003.07; 42 (28): 3251-3253. ( PubMed , DOI )

Yasuda T, Poole AR, Shimizu M, Nakagawa T, Julovi SM, Tamamura H, Fujii N, Nakamura T: Involvement of CD44 in induction of matrix metalloproteinases by a COOH-terminal heparin-binding fragment of fibronectin in human articular cartilage in culture. Arthritis Rheum. 2003.05; 48 (5): 1271-1280. ( PubMed , DOI )

Tamamura H, Koh Y, Ueda S, Sasaki Y, Yamasaki T, Aoki M, Maeda K, Watai Y, Arikuni H, Otaka A, Mitsuya H, Fujii N: Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multidrug resistant HIV-1 strains. J Med Chem. 2003.04; 46 (9): 1764-1768. ( PubMed , DOI )

Fujii N, Nakashima H, Tamamura H: The therapeutic potential of CXCR4 antagonists in the treatment of HIV. Expert Opin Investig Drugs. 2003.02; 12 (2): 185-195. ( PubMed , DOI )

Self-organized calcium carbonate with regular surface-relief structures 2003; 42 (43): 5299-5303. ( DOI )

Oishi S, Kamano T, Niida A, Odagaki Y, Hamanaka N, Yamamoto M, Ajito K, Tamamura H, Otaka A, Fujii N: Diastereoselective synthesis of new psi[(E)-CH=CMe]- and psi[(Z)-CH=CMe]-type alkene dipeptide isosteres by organocopper reagents and application to conformationally restricted cyclic RGD peptidomimetics. J Org Chem. 2002.08; 67 (17): 6162-6173. ( PubMed )

Otaka A, Nakamura M, Nameki D, Kodama E, Uchiyama S, Nakamura S, Nakano H, Tamamura H, Kobayashi Y, Matsuoka M, Fujii N: Remodeling of gp41-C34 peptide leads to highly effective inhibitors of the fusion of HIV-1 with target cells. Angew Chem Int Ed Engl. 2002.08; 41 (16): 2937-2940. ( PubMed , DOI )

Otaka A, Katagiri F, Kinoshita T, Odagaki Y, Oishi S, Tamamura H, Hamanaka N, Fujii N: Regio- and stereoselective synthesis of (E)-alkene trans-Xaa-Pro dipeptide mimetics utilizing organocopper-mediated anti-S(N)2' reactions. J Org Chem. 2002.08; 67 (17): 6152-6161. ( PubMed )

Zhang WB, Navenot JM, Haribabu B, Tamamura H, Hiramatu K, Omagari A, Pei G, Manfredi JP, Fujii N, Broach JR, Peiper SC: A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists. J Biol Chem. 2002.07; 277 (27): 24515-24521. ( PubMed , DOI )

Calcium carbonate-organic hybrid materials 2002.06; 14 (12): 869-877.

Tamamura H, Omagari A, Hiramatsu K, Oishi S, Habashita H, Kanamoto T, Gotoh K, Yamamoto N, Nakashima H, Otaka A, Fujii N: Certification of the critical importance of L-3-(2-naphthyl)alanine at position 3 of a specific CXCR4 inhibitor, T140, leads to an exploratory performance of its downsizing study. Bioorg Med Chem. 2002.05; 10 (5): 1417-1426. ( PubMed )

Oishi S, Kamano T, Niida A, Odagaki Y, Tamamura H, Otaka A, Hamanaka N, Fujii N: Diastereoselective synthesis of psi[(E)-CH=CMe]- and psi[(Z)-CH=CMe]-type dipeptide isosteres by organocopper-mediated anti-S(N)2' reaction. Org Lett. 2002.04; 4 (7): 1051-1054. ( PubMed )

Oishi S, Niida A, Kamano T, Odagaki Y, Tamamura H, Otaka A, Hamanaka N, Fujii N: Diastereoselective synthesis of psi[(E)-CMe=CH]- and psi[(E)-CMe=CMe]- type dipeptide isosteres based on organocopper-mediated anti-S(N)2' reaction. Org Lett. 2002.04; 4 (7): 1055-1058. ( PubMed )

Tamamura H, Hiramatsu K, Miyamoto K, Omagari A, Oishi S, Nakashima H, Yamamoto N, Kuroda Y, Nakagawa T, Otaka A, Fujii N: Synthesis and evaluation of pseudopeptide analogues of a specific CXCR4 inhibitor, T140: the insertion of an (E)-alkene dipeptide isostere into the betaII'-turn moiety. Bioorg Med Chem Lett. 2002.03; 12 (6): 923-928. ( PubMed )

Shinya Oishi, Ayumu Niida, Takae Kamano, Yoshihisa Miwa, Tooru Taga, Yoshihiko Odagaki, Nobuyuki Hamanaka, Mikio Yamamoto, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka & Nobutaka Fujii: Regio- and Stereoselective Ring-opening of Chiral 1,3-Oxazolidin-2-one Derivatives by Organocopper Reagents Provides Novel Access to Di-, tri- and tetra-substituted Alkene Dipeptide Isosteres. J. Chem. Soc., Perkin Trans.. 2002; 1 (2002(15)): 1786-1793.

Hirokazu Tamamura, Tadakazu Hori, Akira Otaka & Nobutaka Fujii: Efficient Stereoselective Synthesis of Peptidomimetics Containing Hydroxyethylamine Dipeptide Isosteres Utilizing the Aza-Payne Rearrangement and O, N-Acyl Transfer Reactions. J. Chem. Soc., Perkin Trans.. 2002; 1 (2002(5)): 577-580.

Tamamura H: [Development of selective antagonists against an HIV second receptor] Yakugaku Zasshi. 2001.11; 121 (11): 781-792. ( PubMed )

Fujii N, Tamamura H: Peptide-lead CXCR4 antagonists with high anti-HIV activity. Curr Opin Investig Drugs. 2001.09; 2 (9): 1198-1202. ( PubMed )

Tamamura H, Omagari A, Hiramatsu K, Kanamoto T, Gotoh K, Kanbara K, Yamamoto N, Nakashima H, Otaka A, Fujii N: Synthesis and evaluation of bifunctional anti-HIV agents based on specific CXCR4 antagonists-AZT conjugation. Bioorg Med Chem. 2001.08; 9 (8): 2179-2187. ( PubMed )

Tamamura H, Omagari A, Hiramatsu K, Gotoh K, Kanamoto T, Xu Y, Kodama E, Matsuoka M, Hattori T, Yamamoto N, Nakashima H, Otaka A, Fujii N: Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140. Bioorg Med Chem Lett. 2001.07; 11 (14): 1897-1902. ( PubMed )

Gotoh K, Yoshimori M, Kanbara K, Tamamura H, Kanamoto T, Mochizuki K, Fujii N, Nakashima H: Increase of R5 HIV-1 infection and CCR5 expression in T cells treated with high concentrations of CXCR4 antagonists and SDF-1. J Infect Chemother. 2001.03; 7 (1): 28-36. ( PubMed , DOI )

Tamamura H, Sugioka M, Odagaki Y, Omagari A, Kan Y, Oishi S, Nakashima H, Yamamoto N, Peiper SC, Hamanaka N, Otaka A, Fujii N: Conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity. Bioorg Med Chem Lett. 2001.02; 11 (3): 359-362. ( PubMed )

Kenji Kanbara, Setsuko Sato, Jun-ichi Tanuma, Hirokazu Tamamura, Kazuyo Gotoh, Manabu Yoshimori, Taisei Kanamoto, Motoo Kitano, Nobutaka Fujii & Hideki Nakashima: Biological and Genetic Characterization of a Human Immunodeficiency Virus Strain Resistant to CXCR4 Antagonist T134. AIDS Res. Hum. Retroviruses. 2001; 17 (7): 615-622.

Shinya Oishi, Hirokazu Tamamura, Masaki Yamashita, Yoshihiko Odagaki, Nobuyuki Hamanaka, Akira Otaka & Nobutaka Fujii: Stereoselective Synthesis of a Set of Two Functionalized (E)-Alkene Dipeptide Isosteres of L-Amino Acid-L-Glu and L-Amino acid-D-Glu. J. Chem. Soc., Perkin Trans.. 2001; 1 (19): 2445-2451.

Akira Otaka, Hideaki Watanabe, Akira Yukimasa, Shinya Oishi, Hirokazu Tamamura & Nobutaka Fujii: New Access to α-Substituted (Z)-Fluoroalkene Dipeptide Isosteres Utilizing Organocopper Reagents under 'Reduction-oxidative Alkylation (R-OA)' Conditions. Tetrahedron Lett.. 2001; 42 (2): 5443-5446.

玉村　啓和: HIV侵入の第二受容体に対する特異的拮抗剤の発見と応用に関する研究 薬学雑誌. 2001; 121 (11): 781-792.

Tamamura H, Omagari A, Oishi S, Kanamoto T, Yamamoto N, Peiper SC, Nakashima H, Otaka A, Fujii N: Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes. Bioorg Med Chem Lett. 2000.12; 10 (23): 2633-2637. ( PubMed )

Miyoshi K, Otaka A, Kaneko M, Tamamura H, Fujii N: A new practical strategy for the synthesis of long-chain phosphopeptide. Chem Pharm Bull (Tokyo). 2000.08; 48 (8): 1230-1233. ( PubMed )

Otaka A, Mitsuyama E, Kinoshita T, Tamamura H, Fujii N: Stereoselective synthesis of CF(2)-substituted phosphothreonine mimetics and their incorporation into peptides using newly developed deprotection procedures. J Org Chem. 2000.08; 65 (16): 4888-4899. ( PubMed )

Tamamura H, Bienfait B, Nacro K, Lewin NE, Blumberg PM, Marquez VE: Conformationally constrained analogues of diacylglycerol (DAG). 17. Contrast between sn-1 and sn-2 DAG lactones in binding to protein kinase C. J Med Chem. 2000.08; 43 (17): 3209-3217. ( PubMed )

Udaka K, Wiesmuller KH, Kienle S, Jung G, Tamamura H, Yamagishi H, Okumura K, Walden P, Suto T, Kawasaki T: An automated prediction of MHC class I-binding peptides based on positional scanning with peptide libraries. Immunogenetics. 2000.08; 51 (10): 816-828. ( PubMed )

Akira Otaka, Etsuko Mitsuyama, Hideaki Watanabe, Hirokazu Tamamura & Nobutaka Fujii: Development of New Methodology for the Synthesis of Functionalized α-Fluorophosphonates and Its Practical Application to the Preparation of Phosphopeptide Mimetics. Chem. Commun.. 2000; 1081-1082.

Kakugawa K, Udaka K, Nakashima K, Inaba K, Oka Y, Sugiyama H, Tamamura H, Yamagishi H: Efficient induction of peptide-specific cytotoxic T lymphocytes by LPS-activated spleen cells. Microbiol Immunol. 2000; 44 (2): 123-133. ( PubMed )

Aragonite CaCO3 thin-film formation by cooperation of Mg2+ and organic polymer matrices 2000; 6 (6): 487-488.

Murakami T, Zhang TY, Koyanagi Y, Tanaka Y, Kim J, Suzuki Y, Minoguchi S, Tamamura H, Waki M, Matsumoto A, Fujii N, Shida H, Hoxie JA, Peiper SC, Yamamoto N: Inhibitory mechanism of the CXCR4 antagonist T22 against human immunodeficiency virus type 1 infection. J Virol. 1999.09; 73 (9): 7489-7496. ( PubMed )

Xu Y, Tamamura H, Arakaki R, Nakashima H, Zhang X, Fujii N, Uchiyama T, Hattori T: Marked increase in anti-HIV activity, as well as inhibitory activity against HIV entry mediated by CXCR4, linked to enhancement of the binding ability of tachyplesin analogs to CXCR4. AIDS Res Hum Retroviruses. 1999.03; 15 (5): 419-427. ( PubMed , DOI )

Arakaki R, Tamamura H, Premanathan M, Kanbara K, Ramanan S, Mochizuki K, Baba M, Fujii N, Nakashima H: T134, a small-molecule CXCR4 inhibitor, has no cross-drug resistance with AMD3100, a CXCR4 antagonist with a different structure. J Virol. 1999.02; 73 (2): 1719-1723. ( PubMed )

Hirokazu Tamamura, Masaki Yamashita, Yutaka Nakajima, Kyoko Sakano, Akira Otaka, Hiroaki Ohno, Toshiro Ibuka & Nobutaka Fujii: Regiospecific Ring-Opening Reactions of β-Aziridinyl α,β-Enoates with Acids: Application to the Stereoselective Synthesis of a Couple of Diastereoisomeric (E)-Alkene Dipeptide Isosteres from a Single β-Aziridinyl α,β-Enoate and to the Convenient Preparation of Amino Alcohols Bearing α,β-Unsaturated Ester Groups. J. Chem. Soc., Perkin Trans.. 1999; 1 2983-2996.

Tamamura H, Xu Y, Hattori T, Zhang X, Arakaki R, Kanbara K, Omagari A, Otaka A, Ibuka T, Yamamoto N, Nakashima H, Fujii N: A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140. Biochem Biophys Res Commun. 1998.12; 253 (3): 877-882. ( PubMed , DOI )

Hattori T, Komoda H, Pahwa S, Tateyama M, Zhang X, Xu Y, Oguma S, Tamamura H, Fujii N, Fukutake K, Uchiyama T: Decline of anti-DP107 antibody associated with clinical progression. AIDS. 1998.08; 12 (12): 1557-1559. ( PubMed )

Tamamura H, Imai M, Ishihara T, Masuda M, Funakoshi H, Oyake H, Murakami T, Arakaki R, Nakashima H, Otaka A, Ibuka T, Waki M, Matsumoto A, Yamamoto N, Fujii N: Pharmacophore identification of a chemokine receptor (CXCR4) antagonist, T22 ([Tyr(5,12),Lys7]-polyphemusin II), which specifically blocks T cell-line-tropic HIV-1 infection. Bioorg Med Chem. 1998.07; 6 (7): 1033-1041. ( PubMed )

Oguchi M, Higashi K, Taniguchi M, Nishikawa T, Tamamura H, Okimura T, Yamamoto I: Single photon emission CT images in a case of intraventricular neurocytoma. Ann Nucl Med. 1998.06; 12 (3): 161-164. ( PubMed )

Tamamura H, Waki M, Imai M, Otaka A, Ibuka T, Waki K, Miyamoto K, Matsumoto A, Murakami T, Nakashima H, Yamamoto N, Fujii N: Downsizing of an HIV-cell fusion inhibitor, T22 ([Tyr5,12, Lys7]-polyphemusin II), with the maintenance of anti-HIV activity and solution structure. Bioorg Med Chem. 1998.04; 6 (4): 473-479. ( PubMed )

Tamamura H, Arakaki R, Funakoshi H, Imai M, Otaka A, Ibuka T, Nakashima H, Murakami T, Waki M, Matsumoto A, Yamamoto N, Fujii N: Effective lowly cytotoxic analogs of an HIV-cell fusion inhibitor, T22 ([Tyr5,12, Lys7]-polyphemusin II). Bioorg Med Chem. 1998.02; 6 (2): 231-238. ( PubMed )

Hirokazu Tamamura, Tsunehito Ishihara, Hiromi Oyake, Makoto Imai, Akira Otaka, Toshiro Ibuka, Rieko Arakaki, Hideki Nakashima, Tsutomu Murakami, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto & Nobutaka Fujii: Convenient One-pot Synthesis of Cystine-Containing Peptides Using the Trimethylsilyl Chloride-Dimethylsulfoxide/Trifluoroacetic Acid System and its Application to the Synthesis of Bifunctional Anti-HIV Compounds. J. Chem. Soc., Perkin Trans.. 1998; 1 (3): 495-500.

Hiroaki Ohno, Kiyonori Ishii, Asami Honda, Hirokazu Tamamura, Nobutaka Fujii, Yoshiji Takemoto & Toshiro Ibuka: A 2,3-cis-Selective Synthesis of Aziridines Bearing a Vinyl Group from Allyl Methyl Carbonates and Allyl Mesylates. J. Chem. Soc., Perkin Trans.. 1998; 1 (22): 3703-3716.

Uenishi H, Iwanami N, Yamagishi H, Nakatani T, Kawasaki T, Tamamura H, Fujii N, Kuribayashi K: Induction of cross-reactivity in an endogenous viral peptide non-reactive to FBL-3 tumor-specific helper T-cell clones. Microbiol Immunol. 1998; 42 (7): 479-484. ( PubMed )

玉村　啓和・藤井　信孝: Coreceptorを標的とした抗エイズ薬剤の開発状況 日本ME学会雑誌BioMedical Engineering. 1998; 12 (10): 44-51.

Murakami T, Nakajima T, Koyanagi Y, Tachibana K, Fujii N, Tamamura H, Yoshida N, Waki M, Matsumoto A, Yoshie O, Kishimoto T, Yamamoto N, Nagasawa T: A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection. J Exp Med. 1997.10; 186 (8): 1389-1393. ( PubMed )

Ibuka T, Mimura N, Ohno H, Nakai K, Akaji M, Habashita H, Tamamura H, Miwa Y, Taga T, Fujii N, Yamamoto Y: Palladium(0)-Catalyzed Isomerization Reactions of Aziridines Bearing an alpha,beta-Unsaturated Ester Group: A Thermodynamic Preference for Chiral Alkyl (2E)-4,5-cis-4,5-Epimino-N-(alkyl- or arylsulfonyl) 2-Enoates over the Other Three Stereoisomers. J Org Chem. 1997.05; 62 (9): 2982-2991. ( PubMed )

Hiroshi Aoyama, Norio Mimura, Hiroaki Ohno, Kiyonori Ishii, Ayako Toda, Hirokazu Tamamura, Akira Otaka, Nobutaka Fujii & Toshiro Ibuka: Regio- and Stereoselectivity in Reactions of 2,3-cis- and trans-3-Alkyl-2-vinylaziridines with Organocopper Reagents: Importance of 2,3-cis-Stereochemistry in Controlling Selectivity. Tetrahedron Lett.. 1997; 38 (42): 7383-7386.

Hiroaki Ohno, Norio Mimura, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii, Toshiro Ibuka, Isao Shimizu, Akiharu Satake & Yoshinori Yamamoto: Palladium-Catalyzed Reductive Ring Opening with Formic Acid of Aziridines Bearing an α, β-Unsaturated Ester Group. Tetrahedron. 1997; 53 (38): 12933-12946.

Toshiro Ibuka, Norio Mimura, Hiroshi Aoyama, Masako Akaji, Hiroaki Ohno, Yoshihisa Miwa, Tooru Taga, Kazuo Nakai, Hirokazu Tamamura, Nobutaka Fujii & Yoshinori Yamamoto: A Thermodynamic Preference of Chiral N-Methanesulfonyl and N-Arenesulfonyl 2,3-cis-3-Alkyl-2-vinylaziridines over Their 2,3-trans-Isomers: Useful Palladium(0)-Catalyzed Equilibration Reactions for the Synthesis of (E)-Alkene Dipeptide Isosters. J. Org. Chem.. 1997; 62 (4): 999-1015.

Hiromu Habashita, Takeshi Kawasaki, Masako Akaji, Hirokazu Tamamura, Tetsutaro Kimachi, Nobutaka Fujii & Toshiro Ibuka: One-Pot Transformation of p-Toluenesulfonates of 2,3-Epoxy Alcohols into Allylic Alcohols. Tetrahedron Lett.. 1997; 38 (48): 8307-8310.

Tamamura H, Otaka A, Murakami T, Ibuka T, Sakano K, Waki M, Matsumoto A, Yamamoto N, Fujii N: An anti-HIV peptide, T22, forms a highly active complex with Zn(II). Biochem Biophys Res Commun. 1996.12; 229 (2): 648-652. ( PubMed , DOI )

Tamamura H, Ishihara T, Otaka A, Murakami T, Ibuka T, Waki M, Matsumoto A, Yamamoto N, Fujii N: Analysis of the interaction of an anti-HIV peptide, T22 ([Tyr5, 12, Lys7]-polyphemusin II), with gp120 and CD4 by surface plasmon resonance. Biochim Biophys Acta. 1996.11; 1298 (1): 37-44. ( PubMed )

Tamamura H, Otaka A, Murakami T, Ishihara T, Ibuka T, Waki M, Matsumoto A, Yamamoto N, Fujii N: Interaction of an anti-HIV peptide, T22, with gp120 and CD4. Biochem Biophys Res Commun. 1996.02; 219 (2): 555-559. ( PubMed , DOI )

Toshiro Ibuka, Masako Akaji, Norio Mimura, Hiromu Habashita, Kazuo Nakai, Hirokazu Tamamura, Nobutaka Fujii & Yoshinori Yamamoto: A Thermodynamic Preference of Chiral cis-γ,δ-Epimino-(E)-α,β-Unsaturated Esters over Other Stereoisomers: Synthetically Useful Pd(0)-Catalyzed Equilibrated Reactions of Aziridines Bearing an α,β-Unsaturated Ester Groups. Tetrahedron Lett.,. 1996; 37 2849-2852.

Toshiro Ibuka, Kazuo Nakai, Masako Akaji, Hirokazu Tamamura, Nobutaka Fujii & Yoshinori Yamamoto: An Aza-Payne Rearrangement-Epoxide Ring Opening Reaction of 2-Aziridinemethanols in a One-pot Manner: A Regio- and Stereoselective Synthetic Route to Diastereomerically Pure N-Protected 1,2-Amino Alcohols. Tetrahedron. 1996; 52 11739-11752.

Norio Mimura, Toshiro Ibuka, Masako Akaji, Yoshihisa Miwa, Tooru Taga, Kazuo Nakai, Hirokazu Tamamura, Nobutaka Fujii & Yoshinori Yamamoto: An Unusual Thermodynamic Preference of Chiral N-Arylsulfonyl cis-3-Alkyl-2-vinylaziridines over Their trans-Isomers: Palladium(0)-Catalyzed Equilibration Reaction. J. Chem. Soc., Chem. Commun.. 1996; 351-352.

Nobutaka Fujii, Hiromu Habashita, Masako Akaji, Kazuo Nakai, Toshiro Ibuka, Masahiro Fujiwara, Hirokazu Tamamura & Yoshinori Yamamoto: A Simple One-pot Transformation of p-Toluenesulfonates of 2,3-Epoxy Alcohols into Allylic Alcohols. J. Chem. Soc., Perkin Trans. (Perkin Commun.). 1996; 1 1996, 865-866.

Michinori Waki, Koji Waki, Kenji Miyamoto, Akiyoshi Matsumoto, Hirokazu Tamamura, Nobutaka Fujii, Tsutomu Murakami, Hideki Nakashima & Naoki Yamamoto: Molecular Size of an Anti-HIV Peptide, T22, Can Be Reduced without Loss of the Activity. Chem. Lett.. 1996; 571-572.

Hirokazu Tamamura, Tsunehito Ishihara, Akira Otaka, Takaki Koide, Kengo Miyoshi, Toshiro Ibuka & Nobutaka Fujii: A Convenient One-pot Synthesis of Cystine-Containing Peptides from Protected Peptidyl Resins Using the Trimethylsilyl Chloride-Dimethylsulfoxide-Trifluoroacetic Acid System. J. Chem. Soc., Perkin Trans. (Perkin Commun.). 1996; 1 1911-1912.

Kondo T, Uenishi H, Shimizu T, Hirama T, Iwashiro M, Kuribayashi K, Tamamura H, Fujii N, Fujisawa R, Miyazawa M, et al.: A single retroviral gag precursor signal peptide recognized by FBL-3 tumor-specific cytotoxic T lymphocytes. J Virol. 1995.11; 69 (11): 6735-6741. ( PubMed )

Weeks BS, Nomizu M, Otaka A, Weston CA, Okusu A, Tamamura H, Yamamoto N, Fujii N: The synthetic [Tyr5,12,Lys7]-polyphemusin II peptide (T22) binds to the CD4 cell surface molecule. Biochem Biophys Res Commun. 1995.10; 215 (2): 626-631. ( PubMed , DOI )

Tamamura H, Murakami T, Horiuchi S, Sugihara K, Otaka A, Takada W, Ibuka T, Waki M, Yamamoto N, Fujii N: Synthesis of protegrin-related peptides and their antibacterial and anti-human immunodeficiency virus activity. Chem Pharm Bull (Tokyo). 1995.05; 43 (5): 853-858. ( PubMed )

Tamamura H, Otaka A, Nakamura J, Okubo K, Koide T, Ikeda K, Ibuka T, Fujii N: Disulfide bond-forming reaction using a dimethyl sulfoxide/aqueous HCl system and its application to regioselective two disulfide bond formation. Int J Pept Protein Res. 1995.04; 45 (4): 312-319. ( PubMed )

Tamamura H, Otaka A, Takada W, Terakawa Y, Yoshizawa H, Masuda M, Ibuka T, Murakami T, Nakashima H, Waki M, et al.: Solution-phase synthesis of an anti-human immunodeficiency virus peptide, T22 ([Tyr5,12,Lys7]-polyphemusin II), and the modification of Trp by the p-methoxybenzyl group of Cys during trimethylsilyl trifluoromethanesulfonate deprotection. Chem Pharm Bull (Tokyo). 1995.01; 43 (1): 12-18. ( PubMed )

Nobutaka Fujii, Kazuo Nakai, Hirokazu Tamamura, Akira Otaka, Norio Mimura, Yoshihisa Miwa, Tooru Taga, Yoshinori Yamamoto & Toshiro Ibuka: SN2' Ring Opening of Aziridines Bearing an α,β-Unsaturated Ester Group with Organocopper Reagents. A New Stereoselective Synthesis Route to (E)-Alkene Dipeptide Isosters. J. Chem. Soc., Perkin Trans.. 1995; 1 1359-1371.

Akira Otaka, Kengo Miyoshi, Terrence R. Burke, Jr., Peter P. Roller, Hideki Kubota, Hirokazu Tamamura & Nobutaka Fujii: Synthesis and Application of N-Boc-L-2-amino-4-(diethylphosphono)-4, 4-difluorobutanoic acid for Solid-Phase Synthesis of Nonhydrolyzable Phosphoserine Peptide Analogs. Tetrahedron Lett.. 1995; 36 927-930.

Akira Otaka, Kengo Miyoshi, Midori Kaneko, Hirokazu Tamamura, Nobutaka Fujii, Motoyoshi Nomizu, Terrence R. Burke, Jr. & Peter P. Roller: Development of Efficient Two-Step Deprotection Methodology for Dimethyl-Protected Phosphoamino Acid-Containing Peptide Resins and Its Application to the Practical Synthesis of Phosphopeptides. J. Org. Chem.. 1995; 60 3967-3974.

Akira Otaka, Kengo Miyoshi, Peter P. Roller, Terrence R. Burke, Jr., Hirokazu Tamamura & Nobutaka Fujii: Practical Synthesis of Phosphopeptides using Dimethyl-protected Phosphoamino Acid Derivatives. J. Chem. Soc., Chem. Commun.. 1995; 387-389.

Toshiro Ibuka, Kazuo Nakai, Hiromu Habashita, Yuka Hotta, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii, Norio Mimura, Yoshihisa Miwa, Tooru Taga, Yukiyasu Chounan & Yoshinori Yamamoto: Aza-Payne Rearrangement of Activated 2-Aziridinemethanols and 2,3-Epoxy Amines under Basic Conditions. J.Org.Chem.. 1995; 60 2044-2058.

Kazuo Nakai, Toshiro Ibuka, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii & Yoshinori Yamamoto: A One-pot Aza-Payne Rearrangement-Epoxide Ring Opening Reaction of 2-Aziridinemethanols: A Regio- and Stereoselective Synthetic Route to Diastereomerically Pure 1,2-Amino Alcohols. Tetrahedron Lett.. 1995; 36 6247-6250.

Tamamura H, Murakami T, Masuda M, Otaka A, Takada W, Ibuka T, Nakashima H, Waki M, Matsumoto A, Yamamoto N, et al.: Structure-activity relationships of an anti-HIV peptide, T22. Biochem Biophys Res Commun. 1994.12; 205 (3): 1729-1735. ( PubMed )

Shimizu T, Uenishi H, Teramura Y, Iwashiro M, Kuribayashi K, Tamamura H, Fujii N, Yamagishi H: Fine structure of a virus-encoded helper T-cell epitope expressed on FBL-3 tumor cells. J Virol. 1994.12; 68 (12): 7704-7708. ( PubMed )

Otaka A, Tamamura H, Terakawa Y, Masuda M, Koide T, Murakami T, Nakashima H, Matsuzaki K, Miyajima K, Ibuka T, et al.: Molecular parameters for the anti-human immunodeficiency virus activity of T22 ([Tyr5,12, Lys7]-polyphemusin II). Biol Pharm Bull. 1994.12; 17 (12): 1669-1672. ( PubMed )

Weeks BS, Nomizu M, Otaka A, Weston CA, Okusu A, Tamamura H, Matsumoto A, Yamamoto N, Fujii N: Lymphocytes and promonocytes attach to the synthetic [Tyr5,12, Lys7]- polyphemusin II peptide. Biochem Biophys Res Commun. 1994.07; 202 (1): 470-475. ( PubMed )

Nobutaka Fujii, Kazuo Nakai, Hiromu Habashita, Yuka Hotta, Hirokazu Tamamura, Akira Otaka & Toshiro Ibuka: Synthesis of Optically Pure 2-Aziridinemethanols: Versatile Synthetic Building Blocks. Chem. Pharm. Bull.. 1994; 42 2241-2250.

Toshiro Ibuka, Keisuke Suzuki, Hiromu Habashita, Akira Otaka, Hirokazu Tamamura, Norio Mimura, Yoshihisa Miwa, Tooru Taga & Nobutaka Fujii: (E)-Stereoselective Synthesis of Vinylglycines from (R)-Serine via Organocopper-BF3 and Related Reagents. J. Chem. Soc., Chem. Commun.. 1994; 2151-2152.

Tamamura H, Kuroda M, Masuda M, Otaka A, Funakoshi S, Nakashima H, Yamamoto N, Waki M, Matsumoto A, Lancelin JM, et al.: A comparative study of the solution structures of tachyplesin I and a novel anti-HIV synthetic peptide, T22 ([Tyr5,12, Lys7]-polyphemusin II), determined by nuclear magnetic resonance. Biochim Biophys Acta. 1993.05; 1163 (2): 209-216. ( PubMed )

Tamamura H, Ikoma R, Niwa M, Funakoshi S, Murakami T, Fujii N: Antimicrobial activity and conformation of tachyplesin I and its analogs. Chem Pharm Bull (Tokyo). 1993.05; 41 (5): 978-980. ( PubMed )

Tamamura H, Nakamura J, Noguchi K, Funakoshi S, Fujii N: Acceleration of the N alpha-deprotection rate by the addition of m-cresol to diluted methanesulfonic acid and its application to the Z(OMe)-based solid-phase syntheses of human pancreastatin-29 and magainin 1. Chem Pharm Bull (Tokyo). 1993.05; 41 (5): 954-957. ( PubMed )

Toshiro Ibuka, Tooru Taga, Hiromu Habashita, Kazuo Nakai, Hirokazu Tamamura, Nobutaka Fujii, Yukiyasu Chounan, Hisao Nemoto & Yoshinori Yamamoto : Syn-SN2' Pathway in the Reaction of Certain γ-(Mesyloxy)-α,β-Enoates with RCu(CN)MgX.BF3 Reagents. Importance of MgX and Bulky R Group upon the Diastereoselectivity. J. Org. Chem.. 1993; 58 1207-1214.

Hirokazu Tamamura, Akira Otaka, Junko Nakamura, Kaori Okubo, Takaki Koide, Kyoko Ikeda & Nobutaka Fujii.: Disulfide Bond Formation in S-Acetamidomethyl Cysteine-Containing Peptides by the Combination of Silver Trifluoromethanesulfonate and Dimethylsulfoxide / Aqueous HCl. Tetrahedron Lett.. 1993; 34 4931-4934.

Masuda M, Nakashima H, Ueda T, Naba H, Ikoma R, Otaka A, Terakawa Y, Tamamura H, Ibuka T, Murakami T, et al.: A novel anti-HIV synthetic peptide, T-22 ([Tyr5,12,Lys7]-polyphemusin II). Biochem Biophys Res Commun. 1992.12; 189 (2): 845-850. ( PubMed )

Miyasaka K, Funakoshi A, Kitani K, Tamamura H, Funakoshi S, Fujii N: Inhibitory effect of pancreastatin on pancreatic exocrine secretions. Pancreastatin inhibits central vagal nerve stimulation. Gastroenterology. 1990.12; 99 (6): 1751-1756. ( PubMed )

Tamamura H, Ohta M, Yoshizawa K, Ono Y, Funakoshi A, Miyasaka K, Tateishi K, Jimi A, Yajima H, Fujii N, et al.: Isolation and characterization of a tumor-derived human protein related to chromogranin A and its in vitro conversion to human pancreastatin-48. Eur J Biochem. 1990.07; 191 (1): 33-39. ( PubMed )

Miyasaka K, Funakoshi A, Kitani K, Tamamura H, Fujii N, Funakoshi S: The importance of the C-terminal amide structure of rat pancreastatin to inhibit pancreatic exocrine secretion. FEBS Lett. 1990.04; 263 (2): 279-280. ( PubMed )

Miyasaka K, Funakoshi A, Yasunami Y, Nakamura R, Kitani K, Tamamura H, Funakoshi S, Fujii N: Rat pancreastatin inhibits both pancreatic exocrine and endocrine secretions in rats. Regul Pept. 1990.04; 28 (2): 189-198. ( PubMed )

Akihiro Funakoshi, Kyoko Miyasaka, Kenichi Kitani, Susumu Funakoshi, Hirokazu Tamamura, Nobutaka Fujii, Itsuro Nakano & Kazuhiko Tatemoto: Comparative Effects of Mammalian Pancreastatin on the Pancreatic Exocrine Secretion. Japanese J. Pysiol.. 1990; 39 901-905.

Tateishi K, Funakoshi A, Wakasugi H, Iguchi H, Shinozaki H, Abe M, Funakoshi S, Tamamura H, Yajima H, Matsuoka Y: Plasma pancreastatin-like immunoreactivity in various diseases. J Clin Endocrinol Metab. 1989.12; 69 (6): 1305-1308. ( PubMed )

Tateishi K, Funakoshi A, Jimi A, Funakoshi S, Tamamura H, Yajima H, Matsuoka Y: High plasma pancreastatinlike immunoreactivity in a patient with malignant insulinoma. Gastroenterology. 1989.11; 97 (5): 1313-1318. ( PubMed )

Funakoshi S, Tamamura H, Ohta M, Yoshizawa K, Funakoshi A, Miyasaka K, Tateishi K, Tatemoto K, Nakano I, Yajima H, et al.: Isolation and characterization of a tumor-derived human pancreastatin-related protein. Biochem Biophys Res Commun. 1989.10; 164 (1): 141-148. ( PubMed )

Funakoshi A, Jimi A, Yasunami Y, Tateishi K, Funakoshi S, Tamamura H, Yajima H: Bioactivity of human pancreastatin and its localization in pancreas. Biochem Biophys Res Commun. 1989.03; 159 (3): 913-918. ( PubMed )

Funakoshi A, Miyasaka K, Kitani K, Tamamura H, Funakoshi S, Yajima H: Bioactivity of synthetic C-terminal fragment of rat pancreastatin on endocrine pancreas. Biochem Biophys Res Commun. 1989.02; 158 (3): 844-849. ( PubMed )

Nobutaka Fujii, Akira Otaka, Toshihiro Watanabe, Akira Okamachi, Hirokazu Tamamura, Haruaki Yajima, Yoshimasa Inagaki, Motoyoshi Nomizu & Katsuhiko Asano: Silver Trifluoromethanesulphonate as an S-Deprotecting Reagent for the Synthesis of Cystine Peptides. J. Chem. Soc., Chem. Commun.. 1989; 283-284.

Funakoshi A, Miyasaka K, Nakamura R, Kitani K, Funakoshi S, Tamamura H, Fujii N, Yajima H: Bioactivity of synthetic human pancreastatin on exocrine pancreas. Biochem Biophys Res Commun. 1988.11; 156 (3): 1237-1242. ( PubMed )

Susumu Funakoshi, Hirokazu Tamamura, Nobutaka Fujii, Kumi Yoshizawa, Haruaki Yajima, Kyoko Miyasaka, Akihiro Funakoshi, Mitsuhiro Ohta, Yoshimasa Inagaki & Louis A. Carpino: Combination of a New Amide-precursor Reagent and Trimethylsilyl Bromide Deprotection for the Fmoc-based Solid Phase Synthesis of Human Pancreastatin and One of its Fragment. J. Chem. Soc., Chem. Commun.. 1988; 1588-1590.

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鳴瀧彩絵: エラスチンの可能性を拓く ～自己組織化とバイオマテリアル～ 生命化学研究レター. 2019.04; 58 11-16.

Nishijima Yoshiaki, Murayama Takashi, Mori Shuichi, Iinuma Hiroto, Manaka Noriaki, Kurebayashi Nagomi, Ishigami-Yuasa Mari, Kagechika Hiroyuki, Sakurai Takashi: Structure Development of Oxolinic Acid, a Novel Inhibitor of Type 1 Ryanodine Receptor (RyR1) Ca2+ Release Channel BIOPHYSICAL JOURNAL. 2019.02; 116 (3): 521A.

Matsukawa Hiroyuki, Murayama Takashi, Kobayashi Takuya, Kurebayashi Nagomi, Ishigami-Yuasa Mari, Mori Shuichi, Kagechika Hiroyuki, Sakurai Takashi: Identification of Novel RyR1 Inhibitors by High-Throughput Screening using ER Ca2+ Measurement BIOPHYSICAL JOURNAL. 2019.02; 116 (3): 520A.

Murayama Takashi, Kurebayashi Nagomi, Yuasa-Ishigami Mari, Mori Shuichi, Ogawa Haruo, Suzuki Junji, Kanemaru Kazunori, Iino Masamitsu, Kagechika Hiroyuki, Sakurai Takashi: Efficient High-Throughput Screening for Type 1 Ryanodine Receptor Inhibitors using ER Ca2+ Measurements BIOPHYSICAL JOURNAL. 2019.02; 116 (3): 153A.

Kurebayashi Nagomi, Murayama Takashi, Tamura Mai, Mori Shuichi, Yuasa-Ishigami Mari, Kagechika Hiroyuki, Suzuki Junji, Kanemaru Kazunori, Iino Masamitsu, Morimoto Sachio, Sakurai Takashi: Effects of Novel RyR2 Inhibitors on Diseased Hearts BIOPHYSICAL JOURNAL. 2019.02; 116 (3): 521A.

Hirano Tomoya, Mori Shuichi, Kagechika Hiroyuki: Recent Advances in Chemical Tools for the Regulation and Study of Protein Lysine Methyltransferases CHEMICAL RECORD. 2018.12; 18 (12): 1745-1759. ( PubMed , DOI )

村上 努, 海老原 健人, 藤野 真之, 本田 柚子奈, 小早川 拓也, 野村 渉, 玉村 啓和: 二量体化に基づいた新規抗HIV-1膜融合阻害薬の創出 日本エイズ学会誌. 2018.11; 20 (4): 523. ( 医中誌 )

鳴瀧彩絵: 自己集合性ブロックポリペプチドによる機能性ナノファイバーの創製 Peptide Newsletter Japan（日本ペプチド学会）. 2018.10; 110 9-12.

宮下 直樹, 奥平 桂一郎, 川原 遥華, 津田 雄介, 森本 恭平, 辻 耕平, 重永 章, 大高 章, 石田 竜弘: 動脈硬化治療を指向した光制御型HDL構成ペプチドの開発 日本薬剤学会年会講演要旨集. 2018.05; 33年会 179. ( 医中誌 )

Tamura Mai, Kurebayashi Nagomi, Murayama Takashi, Mori Shuichi, Ishigami-Yuasa Mari, Kagechika Hiroyuki, Suzuki Junji, Kanemaru Kazunori, Iino Masamitsu, Sakurai Takashi: Search for Type 2 Ryanodine Receptor Inhibitor by Monitoring Endoplasmic Reticulum Ca2+ BIOPHYSICAL JOURNAL. 2018.02; 114 (3): 116A.

松田 幸樹, 服部 真一朗, 土屋 亮人, 小早川 拓也, 大橋 南美, 野村 渉, 原田 恵嘉, 佐藤 賢文, 吉村 和久, 玉村 啓和, 満屋 裕明, 前田 賢次: HIV潜伏感染細胞を標的とした新規治療薬開発に有効なin vitro評価系の開発 日本エイズ学会誌. 2017.11; 19 (4): 403. ( 医中誌 )

原田 恵嘉, 野村 渉, 鳴海 哲夫, 横山 勝, 前田 賢次, 林 宏典, 紺野 奇重, 引地 優太, 佐藤 裕徳, 玉村 啓和, 俣野 哲朗, 吉村 和久: 網羅的Env標的阻害剤ライブラリーの構築(2) 日本エイズ学会誌. 2017.11; 19 (4): 401. ( 医中誌 )

松本 大亮, 野村 渉, 玉村 啓和: 化合物誘導型ゲノム編集技術の開発 日本バイオマテリアル学会大会予稿集. 2017.11; 39回 162. ( 医中誌 )

村上 努, 金子 萌美, 藤野 真之, 野村 渉, 玉村 啓和: カプシド蛋白質由来ペプチドを基にした新規抗HIV-1剤の創製 日本エイズ学会誌. 2017.11; 19 (4): 400. ( 医中誌 )

Yamasaki Ryu, Iida Mana, Ito Ai, Fukuda Kazuo, Tanatani Aya, Kagechika Hiroyuki, Masu Hyuma, Okamoto Iwao: Crystal Engineering of N,N '-Diphenylurea Compounds Featuring Phenyl-Perfluorophenyl Interaction CRYSTAL GROWTH & DESIGN. 2017.11; 17 (11): 5858-5866. ( DOI )

鳴瀧 彩絵: エラスチン類似ポリペプチドの合理的設計による温度応答性ゲルの創製 コスメトロジー研究報告. 2017.09; 25 16-20. ( 医中誌 )

Mori Shuichi, Hirano Tomoya, Takaguchi Asuka, Fujiwara Takashi, Okazaki Yusuke, Kagechika Hiroyuki: Selective Reagent for Detection of N-epsilon-Monomethylation of a Peptide Lysine Residue through SNAr Reaction EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2017.07; 2017 (25): 3606-3611. ( DOI )

Bao Ngoc Nguyen, Okuno Yukiko, Ajiro Masahiko, Iida Kei, Denawa Masatsugu, Yamamoto Makoto, Sakamoto Naoya, Kagechika Hiroyuki, Hagiwara Masatoshi: Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression JOURNAL OF MEDICAL VIROLOGY. 2017.07; 89 (7): 1224-1234. ( PubMed , DOI )

Yoshioka Hiromasa, Yamada Ayumi, Nishiyama Yuko, Kagechika Hiroyuki, Hashimoto Yuichi, Fujii Shinya: Development of nonsteroidal glucocorticoid receptor modulators based on N-benzyl-N-(4-phenoxyphenyl)benzenesulfonamide scaffold BIOORGANIC & MEDICINAL CHEMISTRY. 2017.07; 25 (13): 3461-3470. ( PubMed , DOI )

川原 遥華, 奥平 桂一郎, 宮下 直樹, 津田 雄介, 森本 恭平, 辻 耕平, 重永 章, 大高 章, 石田 竜弘: 光応答性アポリポタンパク質の開発 日本薬剤学会年会講演要旨集. 2017.05; 32年会 272. ( 医中誌 )

Hai Nam Hoang, Nagashima Yoshihiro, Mori Shuichi, Kagechika Hiroyuki, Matsuda Tomoko: CO2-expanded bio-based liquids as novel solvents for enantioselective biocatalysis TETRAHEDRON. 2017.05; 73 (20): 2984-2989. ( DOI )

Oya Yukiko, Mondal Anupom, Rawangkan Anchalee, Umsumarng Sonthaya, Iida Keisuke, Watanabe Tatsuro, Kanno Miki, Suzuki Kaori, Li Zhenghao, Kagechika Hiroyuki, Shudo Koichi, Fujiki Hirota, Suganuma Masami: Down-regulation of histone deacetylase 4,-5 and-6 as a mechanism of synergistic enhancement of apoptosis in human lung cancer cells treated with the combination of a synthetic retinoid, Am80 and green tea catechin JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 2017.04; 42 7-16. ( PubMed , DOI )

Suzuki Yukina, Akima Ryunosuke, Murayama Takashi, Kurebayashi Nagomi, Ishigami-Yuasa Mari, Mori Syuichi, Kagechika Hiroyuki, Suzuki Junji, Kanemaru Kazunori, Iino Masamitsu, Oyamada Hideto, Oguchi Katsuji, Ogawa Haruo, Toyoshima Chikashi, Sakurai Takashi: A novel screening method for drugs inhibiting type 1 ryanodine receptor (RyR1) by ER Ca2+ monitoring JOURNAL OF PHARMACOLOGICAL SCIENCES. 2017.03; 133 (3): S195.

Tsuji Motonori, Shudo Koichi, Kagechika Hiroyuki: Identifying the receptor subtype selectivity of retinoid X and retinoic acid receptors via quantum mechanics FEBS OPEN BIO. 2017.03; 7 (3): 391-396. ( PubMed , DOI )

Nomura W, Tamamura H: [ZIP tag-probe system: A fluorescence imaging tool for intercellular proteins]. Seikagaku. The Journal of Japanese Biochemical Society. 2017.02; 89 (1): 115-20. ( PubMed )

野村 渉, 玉村 啓和: 細胞内タンパク質を可視化するタグ　蛍光プローブシステム 生化学. 2017.02; 89 (1): 115-119. ( 医中誌 )

鳴瀧彩絵: 無機ナノ粒子と両新媒性高分子が織り成す自己集合と多孔体形成 セラミックス（日本セラミックス協会誌）. 2017.01; 52 (1): 15-19-19.

野村　渉、玉村啓和: 細胞内タンパク質を可視化するタグ—蛍光プローブシステム 「生化学」みにれびゅう（日本生化学会　東京）. 2017.01; 89 (1): 1-6.

Kagechika H, Fujii S, Tanatani A: [Update on recent progress in vitamin D research. Development of novel Vitamin D Derivatives.] Clinical calcium. 2017; 27 (11): 1579-1586. ( PubMed , DOI )

鳴瀧 彩絵, Le Duc H.T., 安永 佐和子, 筒井 陽子, 湯川 博, 馬場 嘉信, 大槻 主税: 高分子材料 ナノファイバー形成能を持つエラスチン類似ポリペプチドへの配列付加による機能化 日本バイオマテリアル学会大会予稿集. 2016.11; シンポジウム2016 104. ( 医中誌 )

鳴瀧彩絵: 目の下のシワを消すローション!? －第二の皮膚として機能する生体模倣ポリマー 化学. 2016.10; 71 (10): 39-42-42.

玉村啓和: 中分子創薬の可能性―ペプチドを創薬へと展開するー 現代化学. 2016; (6月号、543): 47-51.

大橋南美、玉村啓和: ペプチドミメティックを活用した中分子創薬の研究 化学工業　特集「ペプチド化学の最前線(I)」. 2016; 67 (10): 9-17.

野村　渉，玉村啓和: 多価型CXCR4リガンドの創製とがん細胞イメージング・検出 医学のあゆみ　第5土曜特集「GPCR研究の最前線2016」. 2016; 256 (5): 430-437.

鳴瀧彩絵: エラスチン類似ポリペプチドの段階的自己集合 Colloid & Interface Communications. 2015; 40 (2): 12-14.

小早川 拓也: 有機銅試薬によるクロロアルケン類の立体選択的合成法の開発とその応用 国立大学法人 東京医科歯科大学. 2014.03;

玉村啓和: ペプチドミメティックスを活用した抗HIV剤の創製 MEDCHEM NEWS（日本薬学会 医薬化学部会　東京）. 2014; 24 (1): 14-19.

藤井晋也、棚谷綾、平野智也、影近弘之: 球状疎水性ファーマコフォアを有する非セコステロイド型 VDR リガンドの創製研究 Vitamins. 2014; 88 389-395.

今井穣、影近弘之: 核内レチノイド受容体を標的とした新規制癌剤の創製 医学のあゆみ. 2014; 249 1189-1193.

湯浅磨里、影近弘之: ケミカルバイオロジー研究における計測技術 計測と制御. 2014; 53 407-410.

影近弘之: 核内受容体の医薬化学—合成レチノイドの創薬展開 実験医学増刊. 2014; 32 299-305.

鳴瀧彩絵, 大久保達也: 単分散球状シリカナノ粒子が拓くナノアーキテクチャーの世界 表面. 2013; 51 (6): 22-35-331.

鳴瀧彩絵, Duc H. T. Le, 大久保達也: ポリペプチドのデノボデザインに向けて ―エラスチン配列の魅力に迫る 化学. 2013; 68 (12): 66-67.

玉村啓和: ケミカルバイオロジーを基盤とした抗HIV剤の創製. 薬学雑誌レビュー. 2012; 132 (1): 69-78. ( PubMed )

野村　渉、田中智博、相川春夫、玉村啓和: 最新ペプチド合成技術とその創薬研究への応用. 多価結合型GPCRリガンドの合成とがん細胞イメージングへの応用(株式会社　メディカルドゥ). 2012; 267-273.

野村渉、田中智博、相川春夫、玉村啓和: 多価結合型GPCRリガンドの合成とがん細胞イメージングへの応用 遺伝子医学MOOK[21]「最新ペプチド合成技術とその創薬研究への応用」. 2012; 267-273.

鳴海哲夫、玉村啓和: ペプチドミメティックによる創薬研究. 生化学. 2010.06; 82 (6): 515-523. ( PubMed )

野村　渉、増田朱美、玉村啓和: エピジェネティクな遺伝子発現制御のためのDNAメチル化酵素の創製. 生化学. 2010.05; 82 (5): 393-397. ( PubMed )

玉村啓和: ケモカインレセプターCXCR4をターゲットとしたペプチド創薬研究 薬学研究の進歩. 2009; (25): 33-38. ( 医中誌 )

玉村啓和: 種々の作用点をターゲットとした抗HIV剤の創製. 日本エイズ学会誌　（日本エイズ学会）. 2009; 11 (2): 100-101.

深尾 将士, 菅原 彩絵, 下嶋 敦, 大久保 達也: 界面制御による球状シリカナノ粒子の一次元配列 化学工学会 研究発表講演要旨集. 2009; 2009 (0): 369. ( DOI )

下嶋 敦, Mukti Rino, 平原 悠智, 菅原 彩絵, 大久保 達也: 非イオン性界面活性剤のシリル誘導体を用いたMFI型ゼオライトのメソ多孔体化 化学工学会 研究発表講演要旨集. 2009; 2009 (0): 322. ( DOI )

菅原彩絵, 秋吉一成: 会合性高分子の自己組織化 色材協会誌, 81, 178-184 (2008).. 2008; 81 178-184.

西村達也, 山本祐也, 坂本健, 井上宏隆, 長澤寛道, 菅原彩絵, 加藤隆史: バイオミネラリゼーションに倣う炭酸カルシウム/高分子複合体の構築―甲殻類の外骨格に由来するタンパク質およびそれを模倣した合成ペプチドの効果― 日本化学会講演予稿集. 2006.03; 86th (1): 686.

玉村啓和: 【統合創薬の開拓】　抗ウイルス薬・抗AIDS(HIV)薬 BIO Clinica. 2006; 21 (3): 224-230. ( 医中誌 )

玉村啓和: 【ポストゲノム時代の有機化学】　プロテインキナーゼC(PKC)を標的としたDiacylglycerolの環化誘導体の創製 ファルマシア. 2006; 42 (5): 431-435. ( 医中誌 )

山本祐也, 坂本健, 尾市哲, 西村達也, 井上宏隆, 長沢寛道, 菅原彩絵, 加藤隆史: アメリカザリガニのバイオミネラリゼーションに倣う無機/有機複合体の構築 高分子学会予稿集(CD-ROM). 2005.09; 54 (2 Disk1): 3PC087.

山本祐也, 坂本健, 尾市哲, 西村達也, 井上宏隆, 長沢寛道, 菅原彩絵, 加藤隆史: バイオミネラリゼーションに倣う無機/有機複合材料の開発 アメリカザリガニ由来ペプチドの効果 日本化学会講演予稿集. 2005.03; 85th (1): 634.

藤井信孝, 大高章, 玉村啓和: 【飛躍するケミカルバイオロジー　化学から生命現象を明らかに】　ケミカルプロテオミクスによる創薬基盤の革新　情報から制御へ 細胞工学. 2005; 24 (11): 1181-1186. ( 医中誌 )

加藤隆史, 菅原彩絵, 牟田博一: バイオミネラリゼーションに倣う炭酸カルシウム／高分子複合体の構築 未来材料. 2002; 2 (1): 25-29-29.

玉村　啓和: ケモカイン受容体を標的とした抗HIV剤の開発状況 最新医学. 1998; 53 (9): 2040-2046.

Takahashi R, Yamamoto K, Sugahara R, Otake R, Hayashi K, Nakamura J, Ohtsuki C, Aoshima S, Sugawara-Narutaki A: In Situ and Ex Situ Studies of Ring-Like Assembly of Silica Nanoparticles in the Presence of Poly(propylene oxide)-Poly(ethylene oxide) Block Copolymers. Langmuir : the ACS journal of surfaces and colloids. 2023.08; 39 (32): 11379-11387. ( PubMed , DOI )

In Situ Monitoring of Polymerization-Induced Self-Assembly and Gelation During the Synthesis of Triblock Copolymers via Time-Resolved Small-Angle X-ray Scattering and Rheology 2023.05; ( DOI )

Sugioka Yusuke, Nakamura Jin, Ohtsuki Chikara, Sugawara-Narutaki Ayae: Thixotropic Hydrogels Composed of Self-Assembled Nanofibers of Double-Hydrophobic Elastin-Like Block Polypeptides INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021.04; 22 (8): ( PubMed , DOI )

Preparation of layered calcium silicate organically modified with two types of functional groups for varying chemical stability 2021.01; 9 (1): 113-123. ( DOI )

鳴瀧彩絵, LE Duc H. T., LE Duc H. T., 久保田紀城, 筒井陽子, 湯川博, 湯川博, 馬場嘉信, 馬場嘉信, 馬場嘉信, 馬場嘉信, 大槻主税: エラスチン類似ブロックポリペプチドによる機能性ナノファイバーの構築 高分子学会予稿集(CD-ROM). 2016; 65 (2):

王 軍政, 菅原 彩絵, 下嶋 敦, 大久保 達也: Preparation of Anisotropic Silica Nanoparticles Using Seed-Mediated Growth Method 化学工学会 研究発表講演要旨集. 2009; 2009 438. ( DOI )