Chemical Bioscience

225  articles.  
* There may be some overlapped articles listed due to the difference of format.

  1. Shiino H, Tashiro S, Hashimoto M, Sakata Y, Hosoya T, Endo T, Kojima H, Tamura Y: Chemical inhibition of phosphatidylcholine biogenesis reveals its role in mitochondrial division. iScience. 2024.03; 27 (3): 109189. ( PubMed , DOI )

  2. Watanabe K, Mao Q, Zhang Z, Hata M, Kodera M, Kitagishi H, Niwa T, Hosoya T: Clickable bisreactive small gold nanoclusters for preparing multifunctionalized nanomaterials: application to photouncaging of an anticancer molecule. Chem Sci. 2024.01; 15 (4): 1402-1408. ( PubMed , DOI )

  1. Niwa T, Takimoto T, Sakata Y, Hosoya T: Palladium-Catalyzed #Iipso#IR-Borylation of Aryl Halides Promoted by Lewis Acid-Mediated Electrophilic Activation of Aryl(halo)palladium(II) Complex. Org Lett. 2023.11; 25 (45): 8173-8177. ( PubMed , DOI )

  2. Taguchi J, Okuyama T, Tomita S, Niwa T, Hosoya T: Synthesis of Multisubstituted Aromatics via 3-Triazenylarynes. Org Lett. 2023.09; 25 (38): 7030-7034. ( PubMed , DOI )

  3. Zhang Z, Niwa T, Watanabe K, Hosoya T: #U11#URC-Cyanation of Aryl Fluorides via Nickel and Lithium Chloride-Mediated C-F Bond Activation. Angew Chem Int Ed Engl. 2023.05; 62 (22): e202302956. ( PubMed , DOI )

  4. Niwa T, Tahara T, Chase CE, Fang FG, Nakaoka T, Irie S, Hayashinaka E, Wada Y, Mukai H, Masutomi K, Watanabe Y, Cui Y, Hosoya T: Synthesis of #U11#URC-Radiolabeled Eribulin as a Companion Diagnostics PET Tracer for Brain Glioblastoma. Bull Chem Soc Jpn. 2023.03; 96 (3): 283-290. ( DOI )

  5. Dubol M, Immenschuh J, Jonasson M, Takahashi K, Niwa T, Hosoya T, Roslin S, Wikström J, Antoni G, Watanabe Y, Lubberink M, Biegon A, Sundström-Poromaa I, Comasco E: Acute nicotine exposure blocks aromatase in the limbic brain of healthy women: A [#U11#URC]cetrozole PET study. Compr Psychiatry. 2023.03; 123 152381. ( PubMed , DOI )

  6. Sakata Y, Nabekura R, Hazama Y, Hanya M, Nishiyama T, Kii I, Hosoya T: Synthesis of Functionalized Dibenzoazacyclooctynes by a Decomplexation Method for Dibenzo-Fused Cyclooctyne-Cobalt Complexes. Org Lett. 2023.02; 25 (7): 1051-1055. ( PubMed , DOI )

  7. Tabata S, Minoshima M, Kobayashi A, Matsuzawa T, Hosoya T, Yoshida S: Migrative Thioamination of Aryne Intermediates Generated from #Io#IR-Iodoaryl Triflates. Synlett. 2023.02; ( DOI )

  8. Kobayashi A, Matsuzawa T, Hosoya T, Yoshida S: Synthesis of benzo[#Ib#IR]furans from alkynyl sulfoxides and phenols by the interrupted Pummerer reaction. RSC Adv. 2023.01; 13 (2): 839-843. ( PubMed , DOI )

  1. Katayama A, Jin Y, Nishiyama Y, Hosoya T, Yokoshima S: Substitution of α-Azido Sulfones with Thiolates to Form α-Azido Sulfides. Org Lett. 2022.10; 24 (40): 7361-7365. ( PubMed , DOI )

  2. Inouye S, Sato J, Sahara-Miura Y, Tomabechi Y, Sumida Y, Sekine S, Shirouzu M, Hosoya T: Reverse mutants of the catalytic 19 kDa mutant protein (nanoKAZ/nanoLuc) from #IOplophorus#IR luciferase with coelenterazine as preferred substrate. PLoS One. 2022.09; 17 (9): e0272992. ( PubMed , DOI )

  3. Watanabe K, Kuratsu A, Hashizume D, Niwa T, Hosoya T: Red light-induced conjugation of amines through amide bond formation triggered via photooxidation of 3-acylindolizines. Commun Chem. 2022.08; 5 (1): 91. ( PubMed , DOI )

  4. Sugiyama K, Sakata Y, Niwa T, Yoshida S, Hosoya T: Azido-type-selective triazole formation by iridium-catalyzed cycloaddition with thioalkynes. Chem Commun. 2022.05; 58 (42): 6235-6238. ( PubMed , DOI )

  5. Nagai A, Kobayashi A, Sakata Y, Minami Y, Uchida K, Hosoya T, Yoshida S: Synthesis of Multisubstituted Benzenes from Phenols via Multisubstituted Benzynes. Synthesis. 2022.04; 54 (22): 5017-5025. ( DOI )

  6. Fukuchi T, Niwa T, Hosoya T, Watanabe Y: Computational study for amino acid production from carboxylic acid #Ivia#IR #U14#URC β-decay. J Phys Soc Jpn. 2022.04; 91 (6): 064301. ( DOI )

  7. Kimura N, Saito K, Niwa T, Yamanaka M, Igaue S, Ohkanda J, Hosoya T, Kii I: Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY. Protein Expres Purif. 2022.03;

  8. Idogawa R, Kobayashi A, Kim Y, Shimomori K, Hosoya T, Yoshida S: Hydride reduction of #Io#IR-(fluorosilyl)benzodifluorides for subsequent C-F transformations. Chem Commun. 2022.03; 58 (21): 3521-3524. ( PubMed , DOI )

  9. Nakaoka T, Kaneko K, Irie S, Mawatari A, Igesaka A, Uetake Y, Ochiai H, Niwa T, Yamano E, Wada Y, Tanaka M, Kotani K, Kawahata H, Kawabe J, Miki Y, Doi H, Hosoya T, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y: Clinical evaluation of [#U18#URF]pitavastatin for quantitative analysis of hepatobiliary transporter activity. Drug Metab Pharmacok. 2022.02; ( DOI )

  10. Takemura H, Orimoto G, Kobayashi A, Hosoya T, Yoshida S: Modular synthesis of triazoles from 2-azidoacrylamides having a nucleophilic amino group. Org Biomol Chem. 2022.02; ( PubMed , DOI )

  11. Inouye S, Nakamura M, Hosoya T: Enzymatic conversion of dehydrocoelenterazine to coelenterazine using FMN-bound flavin reductase of NAD(P)H:FMN oxidoreductase. Biochem Biophys Res Commun. 2022.01; 587 24-28. ( PubMed , DOI )

  12. Miyazaki Y, Kikuchi M, Umezawa K, Descamps A, Nakamura D, Furuie G, Sumida T, Saito K, Kimura N, Niwa T, Sumida Y, Umehara T, Hosoya T, Kii I: Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A. Eur J Med Chem. 2022.01; 227 113948. ( PubMed , DOI )

  1. Takahashi K, Hosoya T, Onoe K, Mori T, Tazawa S, Mawatari A, Wada Y, Watanabe Y, Doi H, Watanabe Y: PET imaging of brain aromatase in humans and rhesus monkeys by #U11#URC-labeled cetrozole analogs. Sci Rep. 2021.12; 11 (1): 23623. ( PubMed , DOI )

  2. Niwa T, Uetake Y, Isoda M, Takimoto T, Nakaoka M, Hashizume D, Sakurai H, Hosoya T: Lewis acid-mediated Suzuki–Miyaura cross-coupling reaction. Nat Catal. 2021.12; 4 (12): 1080-1088. ( DOI )

  3. Inouye S, Nakamura M, Hosoya T: Formation of Coelenteramine from 2-Peroxycoelenterazine in the Ca#U2+#UR-Binding Photoprotein Aequorin. Photochem Photobiol. 2021.12; ( PubMed , DOI )

  4. Sakata Y, Yoshida S, Hosoya T: Synthesis of Azidoanilines by the Buchwald-Hartwig Amination. J Org Chem. 2021.11; 86 (21): 15674-15688. ( PubMed , DOI )

  5. Taguchi J, Kimura K, Igawa K, Tomooka K, Hosoya T: 3-Azidoarynes: Generation and Regioselective Reactions. Chem Lett. 2021.11; 51 (2): 94-98. ( DOI )

  6. Watanabe K, Terao N, Niwa T, Hosoya T: Direct 3-Acylation of Indolizines by Carboxylic Acids for the Practical Synthesis of Red Light-Releasable Caged Carboxylic Acids. J Org Chem. 2021.09; 86 (17): 11822-11834. ( PubMed , DOI )

  7. Kobayashi K, Matsuzawa T, Hosoya T, Yoshida S: Thioxanthone Synthesis from Benzoic Acid Esters through Directed #Iortho#IR-Lithiation. Chem Lett. 2021.06; 50 (9): 1624-1627. ( DOI )

  8. Aimi T, Meguro T, Kobayashi A, Hosoya T, Yoshida S: Nucleophilic transformations of azido-containing carbonyl compounds via protection of the azido group. Chem Commun. 2021.06; 57 (49): 6062-6065. ( PubMed , DOI )

  9. Yoshida S, Hosoya T: Recent Insertion Reactions of Aryne Intermediates. Modern Aryne Chemistry (Ed. Biju AT). 2021.05; 111-148. ( DOI )

  10. Kobayashi T, Hosoya T, Yoshida S: Facile Synthetic Methods for Diverse #IN#IR-Arylphenylalanine Derivatives via Transformations of Aryne Intermediates and Cross-Coupling Reactions. Bull Chem Soc Jpn. 2021.05; 94 (7): 1823-1832. ( DOI )

  11. Nakajima H, Hazama Y, Sakata Y, Uchida K, Hosoya T, Yoshida S: Diverse diaryl sulfide synthesis through consecutive aryne reactions. Chem Commun. 2021.03; 57 (21): 2621-2624. ( PubMed , DOI )

  12. Matsuzawa T, Hosoya T, Yoshida S: Transition-Metal-Free Synthesis of #IN#IR-Arylphenothiazines through an #IN#IR- and #IS#IR-Arylation Sequence. Org Lett. 2021.03; 23 (6): 2347-2352. ( PubMed , DOI )

  13. Minoshima M, Uchida K, Nakamura Y, Hosoya T, Yoshida S: Acylalkylation of Arynes Generated from #Io#IR-Iodoaryl Triflates with Hydrosilanes and Cesium Fluoride. Org Lett. 2021.03; 23 (5): 1868-1873. ( PubMed , DOI )

  14. Suzuki M, Kanemoto K, Nakamura Y, Hosoya T, Yoshida S: Palladium-Catalyzed Sulfinylation of Aryl- and Alkenylborons with Sulfinate Esters. Org Lett. 2021.03; 23 (9): 3793-3797. ( PubMed , DOI )

  15. Toyomoto M, Inoue A, Iida K, Denawa M, Kii I, Kadj F M N, Kishi T, Im D, Shimamura T, Onogi H, Yoshida S, Iwata S, Aoki J, Hosoya T, Hagiwara M: S1PR3–G#D12#DR-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation. Cell Chem Biol. 2021.02; 28 (8): 1132-1144. ( PubMed , DOI )

  16. Isoda M, Uetake Y, Takimoto T, Tsuda J, Hosoya T, Niwa T: Convergent Synthesis of Fluoroalkenes Using a Dual-Reactive Unit. J Org Chem. 2021.01; 86 (2): 1622-1632. ( PubMed , DOI )

  17. Yoshida S, Sakata Y, Misawa Y, Morita T, Kuribara T, Ito H, Koike Y, Kii I, Hosoya T: Assembly of four modules onto a tetraazide platform by consecutive 1,2,3-triazole formations. Chem Commun. 2021.01; 57 (7): 899-902. ( PubMed , DOI )

  18. Nishiyama Y, Akiyama K, Sakata Y, Hosoya T, Yoshida S: Facile Synthesis of Tetraarylpyrazines by Sequential Cross-coupling Approach. Chem Lett. 2021.01; 50 (1): 180-183. ( DOI )

  19. Inouye S, Sumida Y, Tomabechi Y, Taguchi J, Shirouzu M, Hosoya T: Chiral deaza-coelenterazine analogs for probing a substrate-binding site in the Ca2+-binding photoprotein aequorin. PloS one. 2021; 16 (6): e0251743. ( PubMed , DOI )

  1. Takemura H, Goto S, Hosoya T, Yoshida S: 2-Azidoacrylamides as compact platforms for efficient modular synthesis. Chem Commun (Camb). 2020.12; 56 (99): 15541-15544. ( PubMed , DOI )

  2. Idogawa R, Kim Y, Shimomori K, Hosoya T, Yoshida S: Single C–F Transformations of #Io#IR-Hydrosilyl Benzotrifluorides with Trityl Compounds as All-in-One Reagents. Org Lett. 2020.12; 22 (23): 9292-9297. ( PubMed , DOI )

  3. Terashima N, Sakata Y, Meguro T, Hosoya T, Yoshida S: Triazole formation of phosphinyl alkynes with azides through transient protection of phosphine by copper. Chem Commun (Camb). 2020.11; 56 (90): 14003-14006. ( PubMed , DOI )

  4. Nakano-Kobayashi A, Fukumoto A, Morizane A, Nguyen D T , Le T M, Hashida K, Hosoya T, Takahashi R, Takahashi J, Hori O, Hagiwara M: Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammation. Sci Adv. 2020.11; 6 (46): eabc1428. ( PubMed , DOI )

  5. Matsuzawa T, Hosoya T, Yoshida S: One-step synthesis of benzo[#Ib#IR]thiophenes by aryne reaction with alkynyl sulfides. Chem Sci. 2020.11; 11 (35): 9691-9696. ( DOI )

  6. Jonasson M, Nordeman P, Eriksson J, Wilking H, Wikström J, Takahashi K, Niwa T, Hosoya T, Watanabe Y, Antoni G, Sundström Poromaa I, Lubberink M, Comasco E: Quantification of aromatase binding in the female human brain using [#U11#URC]cetrozole positron emission tomography. J Neurosci Res. 2020.11; 98 (11): 2208-2218. ( PubMed , DOI )

  7. Nakamura Y, Sakata Y, Hosoya T, Yoshida S: Synthesis of Functionalized Benzopyran/Coumarin-Derived Aryne Precursors and Their Applications. Org Lett. 2020.10; 22 (21): 8505-8510. ( PubMed , DOI )

  8. Makio N, Sakata Y, Kuribara T, Adachi K, Hatakeyama Y, Meguro T, Igawa K, Tomooka K, Hosoya T, Yoshida S: (Hexafluoroacetylacetonato)copper(I)-cycloalkyne complexes as protected cycloalkynes. Chem Commun (Camb). 2020.09; 56 (77): 11449-11452. ( PubMed , DOI )

  9. Sato Y, Miyamoto Y, Sumida Y, Hosoya T, Ohmiya H: Boracene-based alkylborate enabled Ni/Ir hybrid catalysis. Org Biomol Chem. 2020.09; 18 (34): 6598-6601. ( PubMed , DOI )

  10. Ikeda M, Matsuzawa T, Morita T, Hosoya T, Yoshida S: Synthesis of Diverse Aromatic Ketones through C-F Cleavage of Trifluoromethyl Group. Chem Eur J. 2020.09; 26 (54): 12333-12337. ( PubMed , DOI )

  11. Sumida Y, Harada R, Sumida T, Johmoto K, Uekusa H, Hosoya T: Synthesis of Dibenzofurans by Cu-Catalyzed Deborylative Ring Contraction of Dibenzoxaborins. Org Lett. 2020.08; 22 (16): 6687-6691. ( PubMed , DOI )

  12. Adachi K, Meguro T, Sakata Y, Igawa K, Tomooka K, Hosoya T, Yoshida S: Selective strain-promoted azide-alkyne cycloadditions through transient protection of bicyclo[6.1.0]nonynes with silver or gold. Chem Commun (Camb). 2020.08; 56 (68): 9823-9826. ( PubMed , DOI )

  13. Inouye S, Nakamura M, Taguchi J, Hosoya T: Identification of a novel oxidation product from yellow fluorophore in the complex of apoPholasin and dehydrocoelenterazine. Bioorganic & medicinal chemistry letters. 2020.07; 30 (19): 127435. ( PubMed , DOI )

  14. Watanabe K, Terao N, Isao Kii, Nakagawa R, Niwa T, Hosoya T: Indolizines Enabling Rapid Uncaging of Alcohols and Carboxylic Acids by Red Light-Induced Photooxidation. Org Lett. 2020.07; 22 (14): 5434-5438. ( PubMed , DOI )

  15. Tamura Y, Minami Y, Nishiyama Y, Sakata Y, Karaki F, Hosoya T, Yoshida S: Synthesis of multisubstituted cycloalkenes through carbomagnesiation of strained cycloalkynes. Chem Commun (Camb). 2020.07; 56 (52): 7147-7150. ( PubMed , DOI )

  16. Kobayashi A, Matsuzawa T, Hosoya T, Yoshida S: One-pot Synthesis of Allyl Sulfides from Sulfinate Esters and Allylsilanes through Reduction of Alkoxysulfonium Intermediates. Chem Lett. 2020.07; 49 (7): 813-816. ( DOI )

  17. Kobayashi T, Hosoya T, Yoshida S: Aryne Reaction and Cross-Coupling Approach for the Synthesis of Diverse #IN#IR-Arylphenylalanine Derivatives. Chem Lett. 2020.07; 49 (7): 809-812. ( DOI )

  18. Nakaoka T, Uetake Y, Kaneko K, Niwa T, Ochia Hi, Irie S, Suezaki Y, Otsuka N, Hayashinaka E, Wada Y, Cui Y, Maeda K, Kusuhara H, Sugiyama Y, Hosoya T, Watanabe Y: Practical synthesis of [#U18#URF]Pitavastatin and Evaluation of Hepatobiliary Transport Activity in Rats by Positron Emission Tomography. Mol Pharm. 2020.06; 17 (6): 1884-1898. ( PubMed , DOI )

  19. Sato Y, Nakamura K, Sumida Y, Hashizume D, Hosoya T, Ohmiya H: Generation of Alkyl Radical through Direct Excitation of Boracene-Based Alkylborate. J Am Chem Soc. 2020.05; 142 (22): 9938-9943. ( PubMed , DOI )

  20. Nishiyama Y, Hosoya T, Yoshida S: Synthesis of benzyl sulfides via substitution reaction at the sulfur of phosphinic acid thioesters. Chem Commun (Camb). 2020.05; 56 (43): 5771-5774. ( PubMed , DOI )

  21. Kobayashi A, Matsuzawa T, Hosoya T, Yoshida S: Sulfoxide synthesis from sulfinate esters under Pummerer-like conditions. Chem Commun (Camb). 2020.05; 56 (40): 5429-5432. ( PubMed , DOI )

  22. Mutsuura K, Sakata Y, Uchida K, Hosoya T, Yoshida S: Synthesis of Thioxanthones through Formal C–H Thiolation of Benzoic Acid Esters and Acid-mediated Direct Cyclization. Chem Lett. 2020.05; 49 (7): 753-756. ( DOI )

  23. Kim Y, Kanemoto K, Shimomori K, Hosoya T, Yoshida S: Functionalization of a Single C-F Bond of Trifluoromethylarenes Assisted by an #Iortho#IR-Silyl Group Using a Trityl-Based All-in-One Reagent with Ytterbium Triflate Catalyst. Chem Eur J. 2020.05; 26 (28): 6136-6140. ( PubMed , DOI )

  24. Inouye S, Miura-Sahara Y, Iimori R, Sakata Y, Hazama Y, Yoshida S, Nakamura M, Hosoya T: A novel yellow fluorescent protein of recombinant apoPholasin with dehydrocoelenterazine. Biochem Biophys Res Commun. 2020.05; 526 (2): 404-409. ( PubMed , DOI )

  25. Kanemoto K, Sakata Y, Hosoya T, Yoshida S: Synthesis of Phenoxathiins and Phenothiazines by Aryne Reactions with Thiosulfonates. Chem Lett. 2020.05; 49 (5): 593-596. ( DOI )

  26. Meguro T, Sakata Y, Morita T, Hosoya T, Yoshida S: Facile assembly of three cycloalkyne-modules onto a platform compound bearing thiophene #IS#IR,#IS#IR-dioxide moiety and two azido groups. Chem Commun (Camb). 2020.04; 56 (34): 4720-4723. ( PubMed , DOI )

  27. Inouye S, Sahara-Miura Y, Nakamura M, Hosoya T: Expression, purification, and characterization of recombinant apoPholasin. Protein Expr Purif. 2020.02; 171 105615. ( PubMed , DOI )

  28. Kobayashi T, Hosoya T, Yoshida S: Consecutive Aryne Generation Strategy for the Synthesis of 1,3-Diarylpyrazoles. J Org Chem. 2020.02; 85 (6): 4448-4462. ( PubMed , DOI )

  29. Niwa T, Hosoya T: Molecular Renovation Strategy for Expeditious Synthesis of Molecular Probes. Bull Chem Soc Jpn. 2020.02; 93 (2): 230-248. ( DOI )

  30. Yazaki J, Kawashima Y, Ogawa T, Kobayashi A, Okoshi M, Watanabe T, Yoshida S, Kii I, Egami S, Amagai M, Hosoya T, Shiroguch Ki, Ohara O: HaloTag-based conjugation of proteins to barcoding-oligonucleotides. Nucleic Acids Res. 2020.01; 48 (2): e8. ( PubMed , DOI )

  1. Kitakaze K, Taniuchi S, Kawano E, Hamada Y, Miyake M, Oyadomari M, Kojima H, Kosako H, Kuribara T, Yoshida S, Hosoya T, Oyadomari S: Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity. eLife. 2019.12; 8 e43302. ( PubMed , DOI )

  2. Nakamura Y, Yoshida S, Hosoya T: Recent Advances in Synthetic Hetaryne Chemistry. Heterocycles. 2019.12; 98 (12): 1623-1677. ( DOI )

  3. Uchida K, Minami Y, Yoshida S, Hosoya T: Synthesis of Diverse γ-Aryl-β-ketoesters via Aryne Intermediates Generated by C-C Bond Cleavage. Org Lett. 2019.11; 21 (22): 9019-9023. ( PubMed , DOI )

  4. Nakamura Y, Ozawa S, Yoshida S, Hosoya T: Facile Synthesis of Diverse 2,6-Disubstituted Arylsilanes via Silylamination and Silylsulfanylation of Aryne Intermediates Generated from #Io#IR-Iodoaryl Triflates. Chem Lett. 2019.11; 48 (11): 1296-1299. ( DOI )

  5. Yoshida S, Goto S, Nishiyama Y, Hazama Y, Kondo M, Matsushita T, Hosoya T: Effect of Resonance on the Clickability of Alkenyl Azides in the Strain-promoted Cycloaddition with Dibenzo-fused Cyclooctynes. Chem Lett. 2019.09; 48 (9): 1038-1041. ( DOI )

  6. Uetake Y, Isoda M, Niwa T, Hosoya T: Synthesis of (2,2-Diborylvinyl)arenes by Rhodium-Catalyzed Desulfanylative #Igem#IR-Diborylation of 2-Arylvinyl Sulfides. Org Lett. 2019.07; 21 (13): 4933-4938. ( PubMed , DOI )

  7. Nakamura Y, Miyata Y, Uchida K, Yoshida S, Hosoya T: 3-Thioaryne Intermediates for the Synthesis of Diverse Thioarenes. Org Lett. 2019.07; 21 (13): 5252-5258. ( PubMed , DOI )

  8. Yoshida S, Hazama Y, Kanemoto K, Nakamura Y, Hosoya T: Facile Synthesis of Diverse #Io#IR-Iodoaryl Triflates from #Io#IR-Silylaryl Triflates by Aluminum-mediated Desilyliodination. Chem Lett. 2019.07; 48 (7): 742-745. ( DOI )

  9. Yoshida S, Hosoya T: Target Identification of Bioactive Compounds by Photoaffinity Labeling Using Diazido Probes. Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules – The Shape of Organic Synthesis to Come. 2019.06; 335-355. ( DOI )

  10. Meguro T, Chen S, Kanemoto K, Yoshida S, Hosoya T: Modular Synthesis of Unsymmetrical Doubly-ring-fused Benzene Derivatives Based on a Sequential Ring Construction Strategy Using Oxadiazinones as a Platform Molecule. Chem Lett. 2019.06; 48 (6): 582-585. ( DOI )

  11. Nishiyama Y, Misawa Y, Hazama Y, Oya K, Yoshida S, Hosoya T: Synthesis of Diverse 3-Azido-5-(azidomethyl)benzene Derivatives via Formal C–H Azidation and Functional Group-Selective Transformations. Heterocycles. 2019.06; 99 (2): 1053-1072. ( DOI )

  12. Watanabe K, Tsuda J, Ochiai H, Niwa T, Hosoya T: Divergent Synthesis of Photoaffinity Probe Candidates by Click Reactions of Azido-Substituted Aryltrifluoromethyldiazirines. Heterocycles. 2019.06; 99 (2): 1366-1387. ( DOI )

  13. Kanemoto K, Yoshida S, Hosoya T: Synthesis of Alkynyl Sulfides by Copper-Catalyzed Thiolation of Terminal Alkynes Using Thiosulfonates. Org Lett. 2019.04; 21 (9): 3172-3177. ( PubMed , DOI )

  14. Yoshida S, Kuribara T, Ito H, Meguro T, Nishiyama Y, Karaki F, Hatakeyama Y, Koike Y, Kii I, Hosoya T: A facile preparation of functional cycloalkynes via an azide-to-cycloalkyne switching approach. Chem Commun. 2019.03; 55 (24): 3556-3559. ( PubMed , DOI )

  15. Toyoda Y, Morimoto K, Suno R, Horita S, Yamashita K Hirata K, Sekiguchi Y, Yasuda S, Shiroishi M, Shimizu T, Urushibata Y, Kajiwara Y, Inazumi T, Hotta Y, Asada H, Nakane T, Shiimura Y, Nakagita T, Tsuge K, Yoshida S, Kuribara T, Hosoya T, Sugimoto Y, Nomura N, Sato M, Hirokawa T, Kinoshita M, Murata T, Takayama K, Yamamoto M, Narumiya S, Iwata S, Kobayashi T: Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface. Nat Chem Biol. 2019.01; 15 (1): 18-26. ( PubMed , DOI )

  1. Zhang Z, Niwa T, Watanabe Y, Hosoya T: Palladium(II)-mediated rapid #U11#URC-cyanation of (hetero)arylborons. Org Biomol Chem. 2018.11; 16 (41): 7711-7716. ( PubMed , DOI )

  2. Takahashi K, Hosoya T, Onoe K, Takashima T, Tanaka M, Ishii A, Nakatomi Y, Tazawa S, Takahashi K, Doi H, Wada Y, Watanabe Y: Association between aromatase in human brains and personality traits. Sci Rep. 2018.11; 8 (1): 16841. ( PubMed , DOI )

  3. Yoshida S, Tanaka J, Nishiyama Y, Hazama Y, Matsushita T, Hosoya T: Further enhancement of the clickability of doubly sterically-hindered aryl azides by #Ipara#IR-amino substitution. Chem Commun. 2018.11; 54 (96): 13499-13502. ( PubMed , DOI )

  4. Sumida Y, Harada R, Sumida T, Hashizume D, Hosoya T: Hydrosilyl Group-directed Iridium-catalyzed peri-Selective C–H Borylation of Ring-fused (Hetero)Arenes. Chem Lett. 2018.10; 47 (10): 1251-1254. ( DOI )

  5. Matsuzawa T, Yoshida S, Hosoya T: Recent advances in reactions between arynes and organosulfur compounds. Tetrahedron Lett. 2018.10; 59 (48): 4197-4208 . ( DOI )

  6. Inouye S, Tomabechi Y, Hosoya T, Sekine S, Shirouzu M: Slow luminescence kinetics of semi-synthetic aequorin: expression, purification and structure determination of #Icf3#IR-aequorin. J Biochem. 2018.09; 164 (3): 247-255. ( PubMed , DOI )

  7. Nishiyama Y, Kamada S, Yoshida S, Hosoya T: Generation of Arynes by Selective Cleavage of a Carbon–Phosphorus Bond of #Io#IR-(Diarylphosphinyl)aryl Triflates Using a Grignard Reagent. Chem Lett. 2018.09; 47 (9): 1216-1219. ( DOI )

  8. Meguro T, Terashima N, Ito H, Koike Y, Kii I, Yoshida S, Hosoya T: Staudinger reaction using 2,6-dichlorophenyl azide derivatives for robust aza-ylide formation applicable to bioconjugation in living cells. Chem Commun. 2018.07; 54 (57): 7904-7907. ( PubMed , DOI )

  9. Matsuzawa T, Uchida K, Yoshida S, Hosoya T: Synthesis of Diverse Phenothiazines by Direct Thioamination of Arynes with #IS#IR-(#Io#IR-Bromoaryl)-#IS#IR-methylsulfilimines and Subsequent Intramolecular Buchwald–Hartwig Amination. Chem Lett. 2018.07; 47 (7): 825-828. ( DOI )

  10. Yoshida S, Kuribara T, Morita T, Matsuzawa T, Morimoto K, Kobayashi T, Hosoya T: Expanding the synthesizable multisubstituted benzo[#Ib#IR]thiophenes via 6,7-thienobenzynes generated from #Io#IR-silylaryl triflate-type precursors. RSC Adv. 2018.06; 8 (39): 21754-21758. ( DOI )

  11. Meguro T, Yoshida S, Igawa K, Tomooka K, Hosoya T: Transient Protection of Organic Azides from Click Reactions with Alkynes by Phosphazide Formation. Org Lett. 2018.06; 20 (13): 4126-4130. ( PubMed , DOI )

  12. Yoshida S, Kanno K, Kii I, Misawa Y, Hagiwara M, Hosoya T: Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions. Chem Commun. 2018.04; 54 (30): 3705-3708. ( PubMed , DOI )

  13. Kii I, Hirahara-Owada S, Yamaguchi M, Niwa T, Koike Y, Sonamoto R, Ito H, Takahashi K, Yokoyama C, Hayashi T, Hosoya T, Watanabe Y: Quantification of receptor activation by oxytocin and vasopressin in endocytosis-coupled bioluminescence reduction assay using nanoKAZ. Anal Biochem. 2018.04; 549 174-183. ( PubMed , DOI )

  14. Ajiro M, Sakai H, Onogi H, Yamamoto M, Sumi E, Sawada T, Nomura T, Kabashima K, Hosoya T, Hagiwara M: CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia. Clin Cancer Res. 2018.04; ( PubMed , DOI )

  15. Kanemoto K, Yoshida S, Hosoya T: Modified Conditions for Copper-Catalyzed #Iipso#IR-Thiolation of Arylboronic Acid Esters with Thiosulfonates. Chem Lett. 2018.01; 47 (1): 85-88. ( DOI )

  1. Kusuhara H, Takashima T, Fujii H, Takashima T, Tanaka M, Ishii A, Tazawa S, Takahashi K, Takahashi K, Tokai H, Yano T, Kataoka M, Inano A, Yoshida S, Hosoya T, Sugiyama Y, Yamashita S, Hojo T, Watanabe Y: Comparison of pharmacokinetics of newly discovered aromatase inhibitors by a cassette microdosing approach in healthy Japanese subjects. Drug Metab Pharmacokinet. 2017.12; 32 (6): 293-300. ( PubMed , DOI )

  2. Yoshida S, Shimizu K, Uchida K, Hazama Y, Igawa K, Tomooka K, Hosoya T: Construction of Condensed Polycyclic Aromatic Frameworks through Intramolecular Cycloaddition Reactions Involving Arynes Bearing an Internal Alkyne Moiety. Chem Eur J. 2017.11; 23 (61): 15332-15335. ( PubMed , DOI )

  3. Matsuzawa T, Uchida K, Yoshida S, Hosoya T: Synthesis of Diverse #Io#IR-Arylthio-Substituted Diaryl Ethers by Direct Oxythiolation of Arynes with Diaryl Sulfoxides Involving Migratory #IO#IR-Arylation. Org Lett. 2017.10; 19 (20): 5521-5524. ( PubMed , DOI )

  4. Hatakeyama M, Sakamoto Y, Ogata K, Sumida Y, Sumida T, Hosoya T, Nakamura S: A study on an unusual S#DN#DR2 mechanism in the methylation of benzyne through nickel-complexation. Phys Chem Chem Phys. 2017.10; 19 (39): 26926-26933. ( PubMed , DOI )

  5. Kanemoto K, Sugimura Y, Shimizu S, Yoshida S, Hosoya T: Rhodium-catalyzed odorless synthesis of diaryl sulfides from borylarenes and #IS#IR-aryl thiosulfonates. Chem Commun. 2017.09; 53 (77): 10640-10643. ( PubMed , DOI )

  6. Sakaguchi H, Uetake Y, Ohashi M, Niwa T, Ogoshi S, Hosoya T: Copper-Catalyzed Regioselective Monodefluoroborylation of Polyfluoroalkenes en Route to Diverse Fluoroalkenes. J Am Chem Soc. 2017.09; 139 (36): 12855-12862. ( PubMed , DOI )

  7. Nakano-Kobayashi A, Awaya T, Kii I, Sumida Y, Okuno Y, Yoshida S, Sumida T, Inoue H, Hosoya T, Hagiwara M: Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice. Proc Natl Acad Sci USA. 2017.09; 114 (38): 10268-10273. ( PubMed , DOI )

  8. Niwa T, Ochiai H, Hosoya T: Facile Transformation of α,β-Unsaturated Carboxylic Acids to Alkenylboronic Esters via Rhodium-Catalyzed Decarbonylative Borylation of α,β-Unsaturated Thioesters. Chem Lett. 2017.09; 46 (9): 1315-1318. ( DOI )

  9. Meguro T, Yoshida S, Hosoya T: Sequential Molecular Conjugation using Thiophene #IS#IR,#IS#IR-Dioxides Bearing a Clickable Functional Group. Chem Lett. 2017.08; 46 (8): 1137-1140. ( DOI )

  10. Nishiyama Y, Hazama Y, Yoshida S, Hosoya T: Synthesis of Unsymmetrical Tertiary Phosphine Oxides via Sequential Substitution Reaction of Phosphonic Acid Dithioesters with Grignard Reagents. Org Lett. 2017.07; 19 (14): 3899-3902. ( PubMed , DOI )

  11. Furubayashi T, Motohashi K, Wakao K, Matsuda T, Kii I, Hosoya T, Hayashi N, Sadaie M, Ishikawa F, Matsushita M, Fujiyoshi S: Three-Dimensional Localization of an Individual Fluorescent Molecule with Angstrom Precision. J Am Chem Soc. 2017.07; 139 (26): 8990-8994. ( PubMed , DOI )

  12. Nakamura Y, Yoshida S, Hosoya T: Facile Synthesis of Phthalides from Methyl #Iortho#IR-Iodobenzoates and Ketones via an Iodine–Magnesium Exchange Reaction Using a Silylmethyl Grignard Reagent. Chem Lett. 2017.06; 46 (6): 858-861. ( DOI )

  13. Sumida Y, Sumida T, Hosoya T: Nickel-Catalyzed Reductive Cross-Coupling of Aryl Triflates and Nonaflates with Alkyl Iodides. Synthesis. 2017.06; 49 (16): 3590-3601. ( DOI )

  14. Sako Y, Ninomiya K, Okuno Y, Toyomoto M, Nishida A, Koike Y, Ohe K, Kii I, Yoshida S, Hashimoto N, Hosoya T, Matsuo M, Hagiwara M: Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy. Sci Rep. 2017.05; 7 46126. ( PubMed , DOI )

  15. Niwa T, Ochia H, Hosoya T: Copper-Catalyzed #Iipso#IR-Borylation of Fluoroarenes. ACS Catal. 2017.05; 7 (7): 4535-4541. ( DOI )

  16. Yoshida S, Nagai A, Uchida K, Hosoya T: Enhancing the Synthetic Utility of 3-Haloaryne Intermediates by their Efficient Generation from Readily Synthesizable #Iortho#IR-Iodoaryl Triflate-type Precursors. Chem Lett. 2017.05; 46 (5): 733-736. ( DOI )

  17. Meguro T, Yoshida S, Hosoya T : Aromatic Azido-selective Reduction via the Staudinger Reaction Using Tri-#In#IR-butylphosphonium Tetrafluoroborate with Triethylamine. Chem Lett. 2017.04; 46 (4): 473-476. ( DOI )

  18. Uchida K, Yoshida S, Hosoya T: Three-Component Coupling of Triflyloxy-Substituted Benzocyclobutenones, Organolithium Reagents, and Arynophiles Promoted by Generation of Aryne via Carbon-Carbon Bond Cleavage. Org Lett. 2017.03; 19 (5): 1184-1187. ( PubMed , DOI )

  19. Ochiai H, Uetake Y, Niwa T, Hosoya T: Rhodium-Catalyzed Decarbonylative Borylation of Aromatic Thioesters for Facile Diversification of Aromatic Carboxylic Acids. Angew Chem Int Ed. 2017.02; 56 (9): 2482-2486. ( PubMed , DOI )

  20. Morita T, Nishiyama Y, Yoshida S, Hosoya T: Facile Synthesis of Multisubstituted Benzo[#Ib#IR]furans via 2,3-Disubstituted 6,7-Furanobenzynes Generated from #Iortho#IR-Iodoaryl Triflate-type Precursors. Chem Lett. 2017.01; 46 (1): 118-121. ( DOI )

  21. Morita T, Yoshida S, Kondo M, Matsushita T, Hosoya T: Facile Diversification of Simple Benzo[#Ib#IR]thiophenes via Thienobenzyne Intermediates. Chem Lett. 2017.01; 46 (1): 81-84. ( DOI )

  22. Yoshida S, Nakajima H, Uchida K, Yano T, Kondo M, Matsushita T, Hosoya T: Reactions of Arynes with Sulfoximines: Formal Sulfinylamination vs. #IN#IR-Arylation. Chem Lett. 2017.01; 46 (1): 77-80. ( DOI )

  1. Yoshida S, Nakamura Y, Uchida K, Hazama Y, Hosoya T: Aryne Relay Chemistry en Route to Aminoarenes: Synthesis of 3-Aminoaryne Precursors via Regioselective Silylamination of 3-(Triflyloxy)arynes.. Org Lett. 2016.12; 18 (23): 6212-6215. ( PubMed , DOI )

  2. Ochiai H, Niwa T, Hosoya T: Stereoinversion of Stereocongested Carbocyclic Alcohols via Triflylation and Subsequent Treatment with Aqueous #IN#IR,#IN#IR-Dimethylformamide. Org Lett. 2016.12; 18 (23): 5982-5985. ( PubMed , DOI )

  3. Doi H, Sato K, Shindou H, Sumi K, Koyama H, Hosoya T, Watanabe Y, Ishii S, Tsukada H, Nakanishi K, Suzuki M: Blood-brain barrier permeability of ginkgolide: Comparison of the behavior of PET probes 7α-[#U18#URF]fluoro- and 10-#IO#IR-#Ip#IR-[#U11#URC]methylbenzyl ginkgolide B in monkey and rat brains. Bioorg Med Chem. 2016.11; 24 (21): 5148-5157. ( PubMed , DOI )

  4. Okamoto-Uchida Y, Yu R, Miyamura N, Arima N, Ishigami-Yuasa M, Kagechika H, Yoshida S, Hosoya T, Nawa M, Kasama T, Asaoka Y, Alois RW, Elling U, Penninger JM, Nishina S, Azuma N, Nishina H: The mevalonate pathway regulates primitive streak formation via protein farnesylation. Sci Rep. 2016.11; 6 37697. ( PubMed , DOI )

  5. Sumida Y, Sumida T, Hashizume D, Hosoya T: Preparation of Aryne-Nickel Complexes from #Iortho#IR-Borylaryl Triflates. Org Lett. 2016.11; 18 (21): 5600-5603. ( PubMed , DOI )

  6. Yoshida S, Yano T, Nishiyama Y, Misawa Y, Kondo M, Matsushita T, Igawa K, Tomooka K, Hosoya T: Thiazolobenzyne: a versatile intermediate for multisubstituted benzothiazoles. Chem Commun. 2016.09; 52 (75): 11199-11202. ( PubMed , DOI )

  7. Tanaka T, Okuyama-Dobashi K, Murakami S, Chen W, Okamoto T, Ueda K, Hosoya T, Matsuura Y, Ryo A, Tanaka Y, Hagiwara M, Moriishi K: Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation. Antiviral Res. 2016.09; 133 156-164. ( PubMed , DOI )

  8. Controlled Generation of 3-Triflyloxyarynes. Synthesis. 2016.08; 48 (23): 4099-4109. ( DOI )

  9. Yoshida S, Shimomori K, Kim Y, Hosoya T: Single C-F Bond Cleavage of Trifluoromethylarenes with an #Iortho#IR-Silyl Group. Angew Chem Int Ed Engl. 2016.08; 55 (35): 10406-10409. ( PubMed , DOI )

  10. Yoshida S, Morita T, Hosoya T: Synthesis of Diverse Benzotriazoles from Aryne Precursors Bearing an Azido Group via Inter- and Intramolecular Cycloadditions. Chem Lett. 2016.07; 45 (7): 726-728. ( DOI )

  11. Uetake Y, Niwa T, Hosoya T: Rhodium-Catalyzed #Iipso#IR-Borylation of Alkylthioarenes via C-S Bond Cleavage. Org Lett. 2016.06; 18 (11): 2758-2761. ( PubMed , DOI )

  12. Tomabechi Y, Hosoya T, Ehara H, Sekine S, Shirouzu M, Inouye S: Crystal structure of nanoKAZ: The mutated 19 kDa component of #IOplophorus#IR luciferase catalyzing the bioluminescent reaction with coelenterazine. Biochem Biophys Res Commun. 2016.01; 470 (1): 88-93. ( PubMed , DOI )

  13. Isao Kii, Yuto Sumida, Toshiyasu Goto, Rie Sonamoto, Yukiko Okuno, Suguru Yoshida, Tomoe Kato-Sumida, Yuka Koike, Minako Abe, Yosuke Nonaka, Teikichi Ikura, Nobutoshi Ito, Hiroshi Shibuya, Takamitsu Hosoya, Masatoshi Hagiwara: Selective inhibition of the kinase DYRK1A by targeting its folding process. Nat Commun. 2016; 7 11391. ( PubMed , DOI )

  1. Yoshida S, Sugimura Y, Hazama Y, Nishiyama Y, Yano T, Shimizu S, Hosoya T: A mild and facile synthesis of aryl and alkenyl sulfides #Ivia#IR copper-catalyzed deborylthiolation of organoborons with thiosulfonates. Chem Commun. 2015.12; 51 (93): 16613-16616. ( PubMed , DOI )

  2. Okamoto M, Hidaka A, Toyama M, Hosoya T, Yamamoto M, Hagiwara M, Baba M: Selective inhibition of HIV-1 replication by the CDK9 inhibitor FIT-039. Antiviral Res. 2015.11; 123 1-4. ( PubMed , DOI )

  3. Yoshida S, Yano T, Misawa Y, Sugimura Y, Igawa K, Shimizu S, Tomooka K, Hosoya T: Direct thioamination of arynes via reaction with sulfilimines and migratory #IN#IR-arylation. J Am Chem Soc. 2015.11; 137 (44): 14071-14074. ( PubMed , DOI )

  4. Niwa T, Ochiai H, Watanabe Y, Hosoya T: Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C-F Bond Functionalizations. J Am Chem Soc. 2015.11; 137 (45): 14313-14318. ( PubMed , DOI )

  5. Yoshida S, Hosoya T: The Renaissance and Bright Future of Synthetic Aryne Chemistry. Chem Lett. 2015.11; 44 (11): 1450-1460. ( DOI )

  6. Yoshida S, Shimomori K, Nonaka T, Hosoya T: Facile Synthesis of Diverse Multisubstituted #Iortho#IR-Silylaryl Triflates via C–H Borylation. Chem Lett. 2015.10; 44 (10): 1324-1326. ( DOI )

  7. Sonamoto R, Kii I, Koike Y, Sumida Y, Kato-Sumida T, Okuno Y, Hosoya T, Hagiwara M: Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ. Sci Rep. 2015.08; 5 12728. ( PubMed , DOI )

  8. Hosoya T, Iimori R, Yoshida S, Sumida Y, Sahara-Miura Y, Sato J, Inouye S: Concise Synthesis of #Iv#IR-Coelenterazines. Org Lett. 2015.08; 17 (15): 3888-3891. ( PubMed , DOI )

  9. Masaki S, Kii I, Sumida Y, Kato-Sumida T, Ogawa Y, Ito N, Nakamura M, Sonamoto R, Kataoka N, Hosoya T, Hagiwara M: Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis. Bioorg Med Chem. 2015.08; 23 (15): 4434-4441. ( PubMed , DOI )

  10. Morooka S, Hoshina M, Kii I, Okabe T, Kojima H, Inoue N, Okuno Y, Denawa M, Yoshida S, Fukuhara J, Ninomiya K, Ikura T, Furuya T, Nagano T, Noda K, Ishida S, Hosoya T, Ito N, Yoshimura N, Hagiwara M: Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice. Mol Pharmacol. 2015.08; 88 (2): 316-325. ( PubMed , DOI )

  11. Yoshida S, Hazama Y, Sumida Y, Yano T, Hosoya T: An Alternative Method for Generating Arynes from #Iortho#IR-Silylaryl Triflates: Activation by Cesium Carbonate in the Presence of a Crown Ether. Molecules. 2015.06; 20 (6): 10131-10140. ( PubMed , DOI )

  12. Yoshida S, Karaki F, Uchida F, Hosoya T: Generation of cycloheptynes and cyclooctynes #Ivia#IR a sulfoxide-magnesium exchange reaction of readily synthesized 2-sulfinylcycloalkenyl triflates. Chem Commun. 2015.05; 51 (42): 8745-8748. ( PubMed , DOI )

  13. Yoshida S, Uchida K, Hosoya T: Generation of Arynes Using Trimethylsilylmethyl Grignard Reagent for Activation of #Iortho#IR-Iodoaryl or #Iortho#IR-Sulfinylaryl Triflates. Chem Lett. 2015.05; 44 (5): 691-693. ( DOI )

  14. Yoshida M, Kataoka N, Miyauchi K, Ohe K, Iida K, Yoshida S, Nojima T, Okuno Y, Onogi H, Usui T, Takeuchi A, Hosoya T, Suzuki T, Hagiwara M: Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia. Proc Natl Acad Sci USA. 2015.03; 112 (9): 2764-2769. ( PubMed , DOI )

  1. Yoshida S, Uchida K, Igawa K, Tomooka K, Hosoya T: An efficient generation method and remarkable reactivities of 3-triflyloxybenzyne. Chem Commun (Camb.). 2014.11; 50 (95): 15059-15062. ( PubMed , DOI )

  2. Xu F, Peng L, Shinohara K, Morita T, Yoshida S, Hosoya T, Orita A, Otera J: Substituted 5,6,11,12-Tetradehydrodibenzo[a,e]cyclooctenes: Syntheses, Properties, and DFT Studies of Substituted Sondheimer-Wong Diynes. J Org Chem. 2014.11; 79 (23): 11592-11608. ( PubMed , DOI )

  3. Sumida Y, Harada R, Kato-Sumida T, Johmoto K, Uekusa H, Hosoya T: Boron-Selective Biaryl Coupling Approach to Versatile Dibenzoxaborins and Application to Concise Synthesis of Defucogilvocarcin M. Org Lett. 2014.11; 16 (23): 6240-6243. ( PubMed , DOI )

  4. Yoshida S, Nonaka T, Morita T, Hosoya T: Modular synthesis of bis- and tris-1,2,3-triazoles by permutable sequential azide-aryne and azide-alkyne cycloadditions. Org Biomol Chem. 2014.10; 12 (38): 7489-7493. ( PubMed , DOI )

  5. Yoshida S, Hatakeyama Y, Johmoto K, Uekusa H, Hosoya T: Transient protection of strained alkynes from click reaction via complexation with copper. J Am Chem Soc. 2014.10; 136 (39): 13590-13593. ( PubMed , DOI )

  6. Inouye S, Sato J-i, Sahara-Miura Y, Hosoya T, Suzuki T: Unconventional secretion of the mutated 19 kDa protein of Oplophorus luciferase (nanoKAZ) in mammalian cells. Biochem Biophys Res Commun. 2014.08; 450 (4): 1313-1319. ( PubMed , DOI )

  7. Yamamoto M, Onogi H, Kii I, Yoshida S, Iida K, Sakai H, Abe M, Tsubota T, Ito N, Hosoya T, Hagiwara M: CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses. J Clin Invest. 2014.08; 124 (8): 3479-3488. ( PubMed , DOI )

  8. Suzuki M, Doi H, Koyama H, Zhang Z, Hosoya T, Onoe H, Watanabe Y: Pd0-mediated rapid cross-coupling reactions, the rapid C-[11C]methylations, revolutionarily advancing the syntheses of short-lived PET molecular probes. Chem Rec. 2014.06; 14 (3): 516-541. ( PubMed , DOI )

  9. Yoshida S, Misawa Y, Hosoya T: Formal C–H-Azidation Based Shortcut to Diazido Building Blocks for the Versatile Preparation of Photoaffinity Labeling Probes. Eur J Org Chem. 2014.05; (19): 3991-3995. ( DOI )

  10. Takahashi K, Hosoya T, Onoe K, Doi H, Nagata H, Hiramatsu T, Li XL, Watanabe Y, Wada Y, Takashima T, Suzuki M, Onoe H, Watanabe Y: 11C-Cetrozole: An Improved C-11C-Methylated PET Probe for Aromatase Imaging in the Brain. J Nucl Med. 2014.03; 55 (5): 852-857. ( PubMed , DOI )

  11. Sumi K, Inoue Y, Nishio M, Naito Y, Hosoya T, Suzuki M, Hidaka H: IOP-lowering effect of isoquinoline-5-sulfonamide compounds in ocular normotensive monkeys. Bioorg Med Chem Lett. 2014.02; 24 (3): 831-834. ( PubMed , DOI )

  12. Inouye S, Sato J, Sahara-Miura Y, Yoshida S, Hosoya T: Luminescence enhancement of the catalytic 19kDa protein (KAZ) of Oplophorus luciferase by three amino acid substitutions. Biochem Biophys Res Commun. 2014.02; 445 (1): 157-162. ( PubMed , DOI )

  13. Yoshida S, Uchida K, Hosoya T: Generation of arynes triggered by sulfoxide-metal exchange reaction of ortho-sulfinylaryl triflates. Chem Lett. 2014; 43 (1): 116-118. ( DOI )

  1. Tanaka K, Nakamoto Y, Siwu ER, Pradipta AR, Morimoto K, Fujiwara T, Yoshida S, Hosoya T, Tamura Y, Hirai G, Sodeoka M, Fukase K: Development of bis-unsaturated ester aldehydes as amino-glue probes: sequential double azaelectrocyclization as a promising strategy for bioconjugation. Org Biomol Chem. 2013.11; 11 (42): 7326-7333. ( PubMed , DOI )

  2. Miyajima M, Kusuhara H, Takahashi K, Takashima T, Hosoya T, Watanabe Y, Sugiyama Y: Investigation of the effect of active efflux at the blood-brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous system. J Pharm Sci. 2013.09; 102 (9): 3309-3319. ( PubMed , DOI )

  3. Inouye S, Sato J, Sahara-Miura Y, Yoshida S, Kurakata H, Hosoya T: C6-Deoxy coelenterazine analogues as an efficient substrate for glow luminescence reaction of nanoKAZ: the mutated catalytic 19 kDa component of Oplophorus luciferase. Biochem Biophys Res Commun. 2013.07; 437 (1): 23-28. ( PubMed , DOI )

  4. Sumida Y, Kato T, Hosoya T: Generation of arynes via ate complexes of arylboronic esters with an ortho-leaving group. Org Lett. 2013.06; 15 (11): 2806-2809. ( PubMed , DOI )

  5. Inouye S, Sahara-Miura Y, Sato J, Iimori R, Yoshida S, Hosoya T: Expression, purification and luminescence properties of coelenterazine-utilizing luciferases from Renilla, Oplophorus and Gaussia: comparison of substrate specificity for C2-modified coelenterazines. Protein Expr Purif. 2013.03; 88 (1): 150-156. ( PubMed , DOI )

  6. Yoshida S, Hosoya T: Synthesis of diverse aromatic oxophosphorus compounds by the Michaelis-Arbuzov-type reaction of arynes. Chem Lett. 2013; 42 (6): 583-585. ( DOI )

  7. Koyama H, Zhang Z, Ijuin R, Siqin, Son J, Hatta Y, Ohta M, Wakao M, Hosoya T, Doi H, Suzuki M.: Pd(0)-mediated rapid coupling of methyl iodide with excess amounts of benzyl- and cinnamylboronic acid esters: efficient method for incorporation of positron-emitting (11)C radionuclide into organic frameworks by coupling between two sp(3)-hybridized carbons. RSC Adv. 2013; 3 (24): 9391-9401. ( DOI )

  1. Yoshimura SH, Khan S, Ohno S, Yokogawa T, Nishikawa K, Hosoya T, Maruyama H, Nakayama Y, Takeyasu K: Site-specific attachment of a protein to a carbon nanotube end without loss of protein function. Bioconjug Chem. 2012.07; 23 (7): 1488-1493. ( PubMed , DOI )

  2. Sumida Y, Kato T, Yoshida S, Hosoya T: Palladium-catalyzed regio- and stereoselective hydrosilylation of electron-deficient alkynes. Org Lett. 2012.03; 14 (6): 1552-1555. ( PubMed , DOI )

  1. Ozawa M, Takahashi K, Akazawa KH, Takashima T, Nagata H, Doi H, Hosoya T, Wada Y, Cui Y, Kataoka Y, Watanabe Y: PET of aromatase in gastric parietal cells using 11C-vorozole. J Nucl Med. 2011.12; 52 (12): 1964-1969. ( PubMed , DOI )

  2. Takahashi K, Onoe K, Doi H, Nagata H, Yamagishi G, Hosoya T, Tamura Y, Wada Y, Yamanaka H, Yokoyama C, Mizuma H, Takashima T, Bergström M, Onoe H, Långström B, Watanabe Y: Increase in hypothalamic aromatase in macaque monkeys treated with anabolic-androgenic steroids: PET study with [11C]vorozole. NeuroReport. 2011.05; 22 (7): 326-330. ( PubMed , DOI )

  3. Takahashi K, Yamagishi G, Hiramatsu T, Hosoya A, Onoe K, Doi H, Nagata H, Wada Y, Onoe H, Watanabe Y, Hosoya T: Practical synthesis of precursor of [N-methyl-11C]vorozole, an efficient PET tracer targeting aromatase in the brain. Bioorg Med Chem. 2011.02; 19 (4): 1464-1470. ( PubMed , DOI )

  4. Yoshida S, Shiraishi A, Kanno K, Matsushita T, Johmoto K, Uekusa H, Hosoya T: Enhanced clickability of doubly sterically-hindered aryl azides. Sci Rep. 2011; 1 82. ( PubMed , DOI )

  5. Anwar A, Hosoya T, Leong KM, Onogi H, Okuno Y, Hiramatsu T, Koyama H, Suzuki M, Hagiwara M, Garcia-Blanco MA: The kinase inhibitor SFV785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly. PLoS ONE. 2011; 6 (8): e23246. ( PubMed , DOI )

  6. Islam MS, Nagasaka R, Ohara K, Hosoya T, Ozaki H, Ushio H, Hori M: Biological abilities of rice bran-derived antioxidant phytochemicals for medical therapy. Curr Top Med Chem. 2011; 11 (14): 1847-1853. ( PubMed )

  7. Sakai D, Kii I, Nakagawa K, Matsumoto HN, Takahashi M, Yoshida S, Hosoya T, Takakuda K, Kudo A: Remodeling of actin cytoskeleton in mouse periosteal cells under mechanical loading induces periosteal cell proliferation during bone formation. PLoS ONE. 2011; 6 (9): e24847. ( PubMed , DOI )

  1. Inouye S, Iimori R, Sahara Y, Hisada S, Hosoya T: Application of new semisynthetic aequorins with long half-decay time of luminescence to G-protein-coupled receptor assay. Anal Biochem. 2010.12; 407 (2): 247-252. ( PubMed , DOI )

  2. Abe Y, Okumura E, Hosoya T, Hirota T, Kishimoto T: A single starfish Aurora kinase performs the combined functions of Aurora-A and Aurora-B in human cells. J Cell Sci. 2010.11; 123 (Pt 22): 3978-3988. ( PubMed , DOI )

  3. Ogawa Y., Nonaka Y., Goto T., Ohnishi E., Hiramatsu T., Kii I., Yoshida M., Ikura T., Onogi H., Shibuya H., Hosoya T., Ito N., Hagiwara M.: Development of a novel selective inhibitor of the Downsyndrome-related kinase Dyrk1A. Nat. Commun.. 2010.10; ( PubMed , DOI )

  4. Kohta R, Kotake Y, Hosoya T, Hiramatsu T, Otsubo Y, Koyama H, Hirokane Y, Yokoyama Y, Ikeshoji H, Oofusa K, Suzuki M, Ohta S: 1-Benzyl-1,2,3,4-tetrahydroisoquinoline binds with tubulin beta, a substrate of parkin, and reduces its polyubiquitination. J Neurochem. 2010.09; 114 (5): 1291-1301. ( PubMed , DOI )

  5. Kii I, Shiraishi A, Hiramatsu T, Matsushita T, Uekusa H, Yoshida S, Yamamoto M, Kudo A, Hagiwara M, Hosoya T: Strain-promoted double-click reaction for chemical modification of azido-biomolecules. Org Biomol Chem. 2010.09; 8 (18): 4051-4055. ( PubMed , DOI )

  1. Islam MS, Yoshida H, Matsuki N, Ono K, Nagasaka R, Ushio H, Guo Y, Hiramatsu T, Hosoya T, Murata T, Hori M, Ozaki H: Antioxidant, free radical-scavenging, and NF-kappaB-inhibitory activities of phytosteryl ferulates: structure-activity studies. J Pharmacol Sci. 2009.12; 111 (4): 328-337. ( PubMed )

  2. Ikemoto T, Hosoya T, Takata K, Aoyama H, Hiramatsu T, Onoe H, Suzuki M, Endo M: Functional role of neuroendocrine-specific protein-like 1 in membrane translocation of GLUT4. Diabetes. 2009.12; 58 (12): 2802-2812. ( PubMed , DOI )

  3. Suzuki M, Sumi K, Koyama H, Siqin, Hosoya T, Takashima-Hirano M, Doi H: Pd(0)-Mediated rapid coupling between methyl iodide and heteroarylstannanes: an efficient and general method for the incorporation of a positron-emitting (11)C radionuclide into heteroaromatic frameworks. Chem Eur J. 2009.11; 15 (45): 12489-12495. ( PubMed , DOI )

  4. Inouye S, Hosoya T: Reconstitution of blue fluorescent protein from recombinant apoaequorin and synthetic coelenteramide. Biochem Biophys Res Commun. 2009.09; 386 (4): 617-622. ( PubMed , DOI )

  5. Hosoya T, Inoue A, Hiramatsu T, Aoyama H, Ikemoto T, Suzuki M: Facile synthesis of diazido-functionalized biaryl compounds as radioisotope-free photoaffinity probes by Suzuki-Miyaura coupling. Bioorg Med Chem. 2009.03; 17 (6): 2490-2496. ( PubMed , DOI )

  6. Kuramori C, Azuma M, Kume K, Kaneko Y, Inoue A, Yamaguchi Y, Kabe Y, Hosoya T, Kizaki M, Suematsu M, Handa H: Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus. Biochem Biophys Res Commun. 2009.02; 379 (2): 519-525. ( PubMed , DOI )

  7. Doi H, Ban I, Nonoyama A, Sumi K, Kuang C, Hosoya T, Tsukada H, Suzuki M: Palladium(0)-mediated rapid methylation and fluoromethylation on carbon frameworks by reacting methyl and fluoromethyl iodide with aryl and alkenyl boronic acid esters: useful for the synthesis of [11C]CH(3)--C- and [18F]FCH2--C-Containing PET tracers (PET=positron emission tomography). Chem Eur J. 2009; 15 (16): 4165-4171. ( PubMed , DOI )

  1. Yomoda J, Muraki M, Kataoka N, Hosoya T, Suzuki M, Hagiwara M, Kimura H: Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A. Genes Cells. 2008.03; 13 (3): 233-244. ( PubMed , DOI )

  1. Hiramatsu T, Guo Y, Hosoya T: 3-Azidodifluoromethyl-3H-diazirin-3-yl group as an all-in-one functional group for radioisotope-free photoaffinity labeling. Org Biomol Chem. 2007.09; 5 (18): 2916-2919. ( PubMed , DOI )

  2. Abe M, Ohno S, Yokogawa T, Nakanishi T, Arisaka F, Hosoya T, Hiramatsu T, Suzuki M, Ogasawara T, Sawasaki T, Nishikawa K, Kitamura M, Hori H, Endo Y: Detection of structural changes in a cofactor binding protein by using a wheat germ cell-free protein synthesis system coupled with unnatural amino acid probing. Proteins. 2007.05; 67 (3): 643-652. ( PubMed , DOI )

  3. Ohno S, Matsui M, Yokogawa T, Nakamura M, Hosoya T, Hiramatsu T, Suzuki M, Hayashi N, Nishikawa K: Site-selective post-translational modification of proteins using an unnatural amino acid, 3-azidotyrosine. J Biochem. 2007.03; 141 (3): 335-343. ( PubMed , DOI )

  1. Cui Y, Takamatsu H, Kakiuchi T, Ohba H, Kataoka Y, Yokoyama C, Onoe H, Watanabe Y, Hosoya T, Suzuki M, Noyori R, Tsukada H, Watanabe Y: Neuroprotection by a central nervous system-type prostacyclin receptor ligand demonstrated in monkeys subjected to middle cerebral artery occlusion and reperfusion: a positron emission tomography study. Stroke. 2006.11; 37 (11): 2830-2836. ( PubMed , DOI )

  2. Fukuhara T, Hosoya T, Shimizu S, Sumi K, Oshiro T, Yoshinaka Y, Suzuki M, Yamamoto N, Herzenberg LA, Herzenberg LA, Hagiwara M: Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Proc Natl Acad Sci USA. 2006.07; 103 (30): 11329-11333. ( PubMed , DOI )

  3. Hosoya T, Sumi K, Doi H, Wakao M, Suzuki M: Rapid methylation on carbon frameworks useful for the synthesis of 11CH3-incorporated PET tracers: Pd(0)-mediated rapid coupling of methyl iodide with an alkenyltributylstannane leading to a 1-methylalkene. Org Biomol Chem. 2006.02; 4 (3): 410-415. ( PubMed , DOI )

  1. Hosoya T, Hiramatsu T, Ikemoto T, Aoyama H, Ohmae T, Endo M, Suzuki M: Design of dantrolene-derived probes for radioisotope-free photoaffinity labeling of proteins involved in the physiological Ca2+ release from sarcoplasmic reticulum of skeletal muscle. Bioorg Med Chem Lett. 2005.03; 15 (5): 1289-1294. ( PubMed , DOI )

  1. Suzuki M, Doi H, Kato K, Hosoya T, Watanabe Y, Watanabe Y: Designed molecular probes in brain research: molecular imaging of IP2 receptor in the human brain. Jpn J Neuropsychopharmacol. 2004.08; 24 (4): 221-229. ( PubMed )

  2. Muraki M, Ohkawara B, Hosoya T, Onogi H, Koizumi J, Koizumi T, Sumi K, Yomoda J, Murray MV, Kimura H, Furuichi K, Shibuya H, Krainer AR, Suzuki M, Hagiwara M: Manipulation of alternative splicing by a newly developed inhibitor of Clks. J Biol Chem. 2004.06; 279 (23): 24246-24254. ( PubMed , DOI )

  3. Hosoya T, Hiramatsu T, Ikemoto T, Nakanishi M, Aoyama H, Hosoya A, Iwata T, Maruyama K, Endo M, Suzuki M: Novel bifunctional probe for radioisotope-free photoaffinity labeling: compact structure comprised of photospecific ligand ligation and detectable tag anchoring units. Org Biomol Chem. 2004.03; 2 (5): 637-641. ( PubMed , DOI )

  4. Hosoya T, Wakao M, Kondo Y, Doi H, Suzuki M: Rapid methylation of terminal acetylenes by the Stille coupling of methyl iodide with alkynyltributylstannanes: a general protocol potentially useful for the synthesis of short-lived 11CH3-labeled PET tracers with a 1-propynyl group. Org Biomol Chem. 2004.01; 2 (1): 24-27. ( PubMed , DOI )

  5. Suzuki M, Doi H, Hosoya T, Långström B, Watanabe Y.: Rapid methylation on carbon frameworks leading to the synthesis of a PET tracer capable of imaging a novel CNS-type prostacyclin receptor in living human brain. Trends Anal Chem. 2004; 23 (8): 595-607. ( DOI )

  1. Hosoya T, Aoyama H, Ikemoto T, Kihara Y, Hiramatsu T, Endo M, Suzuki M: Dantrolene analogues revisited: general synthesis and specific functions capable of discriminating two kinds of Ca2+ release from sarcoplasmic reticulum of mouse skeletal muscle. Bioorg Med Chem. 2003.03; 11 (5): 663-673. ( PubMed )

  1. Hosoya T, Aoyama H, Ikemoto T, Hiramatsu T, Kihara Y, Endo M, Suzuki M: [(125)I]-N-[(3-azido-5-iodo)benzyl]dantrolene and [(125)I]-N-[[3-iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)]benzyl]dantrolene: photoaffinity probes specific for the physiological Ca(2+) release from sarcoplasmic reticulum of skeletal muscle. Bioorg Med Chem Lett. 2002.11; 12 (22): 3263-3265. ( PubMed )

  2. Ikenoya M, Hidaka H, Hosoya T, Suzuki M, Yamamoto N, Sasaki Y: Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor. J Neurochem. 2002.04; 81 (1): 9-16. ( PubMed )

  3. Takamatsu H, Tsukada H, Watanabe Y, Cui Y, Kataoka Y, Hosoya T, Suzuki M, Watanabe Y: Specific ligand for a central type prostacyclin receptor attenuates neuronal damage in a rat model of focal cerebral ischemia. Brain Res. 2002.01; 925 (2): 176-182. ( PubMed )

  4. Hamura T, Hosoya T, Yamaguchi H, Kuriyama Y, Tanabe M, Miyamoto M, Yasui Y, Matsumoto T, Suzuki K.: Facile access to versatile polyaromatic building blocks: selectively protected benzocyclobutenedione derivatives via regioselective [2 + 2] cycloaddition of α-alkoxybenzyne and ketene silyl acetal. Helv Chim Acta. 2002; 85 (11): 3589-3604. ( DOI )

  1. Ikemoto T, Hosoya T, Aoyama H, Kihara Y, Suzuki M, Endo M: Effects of dantrolene and its derivatives on Ca(2+) release from the sarcoplasmic reticulum of mouse skeletal muscle fibres. Br J Pharmacol. 2001.10; 134 (4): 729-736. ( PubMed , DOI )

  1. Hosoya T, Hamura T, Kuriyama Y, Miyamoto M, Matsumoto T, Suzuki K.: Silicon-Directed Regioselective [2+2] Cycloaddition of α-Alkoxybenzyne and Ketene Silyl Acetals. Synlett. 2000; (4): 520-522. ( DOI )

  2. Futagami S, Ohashi Y, Imura K, Hosoya T, Omori K, Matsumoto T, Suzuki K.: Total synthesis of ravidomycin: revision of absolute and relative stereochemistry. Tetrahedron Lett. 2000; 41 (7): 1063-1067. ( DOI )

  1. Furuta K, Hosoya T, Tomokiyo K, Okuda S, Kuniyasu A, Nakayama H, Ishikawa T, Suzuki M: [35S]S-[5-(4-benzoylphenyl)pentyl]glutathione: a versatile radioligand targeting GS-X pumps with the ability of photoaffinity labeling. Bioorg Med Chem Lett. 1999.09; 9 (18): 2661-2666. ( PubMed )

  1. Hosoya T, Takashiro E, Yamamoto Y, Matsumoto T, Suzuki K.: Total Syntheses of BE-12406 A and Its C(8)-Vinyl Analog. Heterocycles. 1996; 42 (1): 397-414. ( DOI )

  2. Hosoya T, Ohashi Y, Matsumoto T, Suzuki K.: On the Stereochemistry of Aryl C-Glycosides: Unusual Behavior of Bis-TBDPS Protected Aryl C-Olivosides. Tetrahedron Lett. 1996; 37 (5): 663-666. ( DOI )

  1. Hosoya T, Hasegawa T, Kuriyama Y, Suzuki K: Stereospecificity in [2 + 2] Cycloaddition of Benzyne and Ketene Silyl Acetal. Tetrahedron Lett. 1995; 36 (19): 3377-3380. ( DOI )

  2. Suzuki K, Matsumoto T, Hosoya T.: Total Synthesis of the Gilvocarcins. J Synth Org Chem, Jpn. 1995; 53 (11): 1045-1054.

  3. Hosoya T, Hasegawa T, Kuriyama Y, Matsumoto T, Suzuki K.: [2 + 2] Cycloaddition of Benzyne and Ketene Silyl Acetal as an Efficient Route to Benzocyclobutenones. Synlett. 1995; (2): 177-179. ( DOI )

  4. Hosoya T, Kuriyama Y, Suzuki K.: Convenient Synthesis of Phthalides via Regioselective Baeyer-Villiger Oxidation of Benzocyclobutenones. Synlett. 1995; (6): 635-638. ( DOI )

  1. Hosoya T, Takashiro E, Matsumoto T, Suzuki K.: Total Synthesis of the Gilvocarcins. J Am Chem Soc. 1994; 116 (3): 1004-1015. ( DOI )

  2. Hosoya T, Takashiro E, Matsumoto T, Suzuki K.: First Total Synthesis of BE-12406 A. Tetrahedron Lett. 1994; 35 (26): 4591-4594. ( DOI )

  1. Matsumoto T, Hosoya T, Suzuki K.: Total Synthesis and Absolute Stereochemical Assignment of Gilvocarcin M. J Am Chem Soc. 1992; 114 (9): 3568-3570. ( DOI )

  1. Matsumoto T, Hosoya T, Katsuki M, Suzuki K.: New Efficient Protocol for Aryne Generation. Selective Synthesis of Differentially Protected 1,4,5-Naphthalenetriols. Tetrahedron Lett. 1991; 32 (46): 6735-6736. ( DOI )

  2. Matsumoto T, Hosoya T, Suzuki K.: O->C-Glycoside Rearrangement of Resorcinol Derivatives. Versatile Intermediates in the Synthesis of Aryl C-Glycosides. Synlett. 1991; (10): 709-711. ( DOI )

  1. Matsumoto T, Hosoya T, Suzuki K.: Improvement in O->C-Glycoside Rearrangement Approach to C-Aryl Glycosides: Use of 1-O-Acetyl Sugar as Stable but Efficient Glycosyl Donor. Tetrahedron Lett. 1990; 31 (32): 4629-4632. ( DOI )

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