Organic and Medicinal Chemistry

47  articles.  
* There may be some overlapped articles listed due to the difference of format.

  1. Wongmayura A, Fujii S, Ito S, Kano A, Taoda Y., Kawachi E, Kagechika H, Tanatani A: Novel vitamin D receptor ligands bearing a spherical hydrophobic core structure-Comparison of bicyclic hydrocarbon derivatives with boron cluster derivatives. Bioorganic and Medicinal Chemistry Letters. 2012; 22 1756-1760.

  2. Murakami Y, Kawata A, Seki Y, Koh T, Yuhara K, Maruyama T, MachinoM, Ito S, Kadoma Y, Fujisawa S.: Comparative inhibitory effects of magnolol, honikiol, eugenol, and bis-eugenol on cyclooxygenase-2 expression and nucleo factor kappa B activation in RAW 264.7 cells stimulated with fimriae of Prophyromonas gingivalis. in vivo. 2012; 26 941-950.

  1. Takechi S, Ito S, Kashige N, Ishida T, Yamaguchi T: Glutathion depression by dihydropyrazine derivative. The journal of Toxicological Sciences. 2011; 36 (2): 231-235.

  2. Iwashita M, Fujii S, Ito S, Hirano T, Kagechika H: Efficient and Diversity-Oriented Total Synthesis of Riccardin C and Applicaton to Develop Novel Macrolactam Drivatives. Tetrahedron. 2011; 67 (33): 6073-6082.

  1. Ito S, Takechi S, Nakahara K, Kashige N, and Yamaguchi T: Phenyl-Substituted Dihydropyrazines with DNA Strand-Breakage Activity. Chemical & Pharmaceutical Bulletin. 2010; 58 (6): 825-828.

  2. Ito S, Hirano T, Sugimoto A, Kagechika H, Takechi S, and Yamaguchi T: Latent enamine functionality of 5-methyl-2,3-dihydropyrazines. Chemical & Pharmaceutical Bulletin. 2010; 58 (7): 922-927.

  1. Murakami Y, Ishii H, Hoshina S, Takada N, Ueki A, Tanaka S, Kadoma Y, Ito S, Machino M, Fujisawa S: Antioxidant and Cyclooxygenase-2-inhibiting activity of 4,4'-biphenol, 2,2'-biphenol and phenol. Anticancer Res. 2009; 29 2403-2410.

  2. Kadoma Y, Ito S, Atsumi T, Fujisawa S,: Mechanisms of cytotoxicity of 2- or 2,6-di-tert-butylphenols and 2-methoxyphenols in terms of inhibition rate constant and a theoretical parameter. Chemosphere. 2009; 74 626-632.

  3. Gurbuz I, Yesilada E, Ito S: An anti-ulcerogenic flavonol diglucoside from Equisetum palustre L. Journal of Ethnopharmacology. 2009; 121 360-365.

  1. Kadoma Y, Ito S, Yokoe I, Fujisawa S,: Comparative study of the alkyl and peroxy radical-scavenging activity of 2-t-butyl-4-methoxyphenol (BHA) and its dimer, and their theoretical parameters in vivo. 2008; 22 289-296.

  2. Murakami Y, Ishii H, Takada N, Tanaka S, Machino M, Ito S, Fujisawa S,: Comparative anti-inflammatory activities of curcumin and tetrahydrocurcumin based on the phenolic O-H Bond dissociation enthalpy, ionization potential and quantum chemical descriptor Anticancer Res. 2008; 28 699-708.

  1. Unlu S, Banoglu E, Ito S, Niiya T, Eren G, Okcelik B, Sahin MF,: Synthesis, characterization and preliminary screening of regioisomeric 1-(3-pyridazinyl)-3-arylpyrazole and 1-(3-pyridazinyl)-5-arylpyrazole derivatives towards cyclooxygenase inhibition J. Enzyme Inhibit. Med. Chem.. 2007; 22 351-361.

  2. Murakami Y, Hirata A, Ito S, Shoji M, Tanaka S, Yasui T, Machino M, Fujisawa S: Re-evaluation of cyclooxygenase-2-inhibiting activity of vaniline and guaiacol in macrophage stimulated with lipopolysaccharide. Anticancer Res. 2007; 27 801-808.

  3. Takeda O, Takechi S, Ito S, Omori H, Katoh T, Yamaguchi T,: Effects of phenyl derivatives of dihydropyrazines with ability to generate radical species on Escherichia coli. Biol. Pharm. Bull... 2007; 30 1663-1667.

  4. Yamaguchi T, Ito S, Kashige N, Nakahara K, Harano K.: The relationship between the chemical structures of dihydropyrazine derivatives and DNA strand-breaking activity Chem. Pharm. Bull.. 2007; 55 532-536.

  1. Murano N, Murano M, Ishida K, Kawakami K, Abe Y, Inoue T, Morita E, Yasumoto S, Toshina K, Nishikawa T, Ito S, Hirata I, Katsu K,: Therapeutic effect of SHI-219, a novel water soluble prodrug of EG626(Phtalazinol), on mouse dextran sodium sulfate -induced colitis, Bull. Osaka. Med. Coll.. 2006; 52 69-79.

  1. Hirata A, Murakami Y, Atsumi T, Shoji M, Ogiwara T, Shibuya K, Ito S, Yokoe I, Fujisawa S: Ferulic acid dimmer inhibits lipopolysaccharide-stimulated cyclooxygenase-2 expression in Macrophages. in vivo. 2005; 19 849-854.

  2. Murakami Y, Ito S, Atsumi T, Fujisawa S: Theoretical prediction of the relationship between phenol function and COX-2/AP-1 inhibition for ferulic acid-rrelated compounds. in vivo. 2005; 19 1039-1044.

  3. Sezik E, Aslan M, Yesilada E, Ito S: Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay- directed fractionation techniques. Life Science. 2005; 76 1223-1238.

  1. Fujisawa S, Atsumi T, Kadoma Y, Ishihara M, Ito S, Yokoe I: Kinetic radical scavenging activity and cytotoxicity of 2-methoxy- and 2-t-butyl-substituted phenols and their dimers. Anticancer Res. 2004; 24 (5A): 3019-26.

  2. Onkol T, Yildirim E, Erol K, Ito S, Sahin MF.: Synthesis and antinociceptive activity of (5-chloro-2(3H)-benzothiazolon-3-yl)propanamide derivatives. Archiv der Pharmazie. 2004; 337 475-481.

  3. Onkol T, Sahin MF, Yildirim E, Erol K, Ito S: Synthesis and antinociceptive activity of (5-chloro-2(3H)-benzooxazolon-3-yl)propanamide derivatives. Arch Pharm Research. 2004; 27 (11): 1086-1092.

  1. Yamaguchi T, Nomura H, Matsunaga K, Ito S, Takata J, Karube Y.: The Behavior of Dihydropyrazine with DNA Strand-Breakage Activity in vivo Biological & Pharmaceutical Bulletin. 2003; 26 1523-1527.

  2. Mibu N, Yukawa M, Kashige N, Iwase Y, Goto Y, Miake F, Yamaguchi T, Ito S, Sumoto K: The Behavior of Dihydropyrazine with DNA Strand-Breakage Activity in vivo. CHEM PHARM BULL. 2003; 51 (1): 27-31.

  1. Yamaguchi T, Ito S, Mibu N, Sumoto K.: Reaction of 2,3-butanedione with propylenediamine observed by H-1-NMR spectroscopy. HETEROCYCLES. 2002; 57 (1): 11-16.

  1. Onkol T, Ito S, Yildirim E, Erol K, Sahin MF.: Synthesis and antinociceptive activity of (2-benzazolon-3-yl)propionamide derivatives ARCH PHARM. 2001; 334 (1): 17-20.

  2. Toker G, Aslan M, Yesilada E, Memisoglu M, Ito S Comparative evaluation of the flavonoid content in officinal Tiliae flos and Turkish lime species for quality assessment J PHARMACEUT BIOMED 26 (1): 111-121 AUG 2001: Comparative evaluation of the flavonoid content in officinal Tiliae flos and Turkish lime species for quality assessment J PHARMACEUT BIOMED. 2001; 26 (1): 111-121.

  1. Yamaguchi T, Ito S, Iwase Y, Watanabe K, Harano K.: A diamine-exchange reaction of dihydropyrazines HETEROCYCLES. 2000; 53 (8): 1677.

  2. Dogruer DS, Sahin MF, Unlu S, Ito S.: Studies on some 3(2H)-pyridazinone derivatives with antinociceptive activity ARCH PHARM. 2000; 333 (4): 79-86.

  3. Onkol T, Dogruer DS, Ito S, Sahin MF.: Synthesis and antinociceptive activity of (5-chloro-2-benzothiazolinon-3-yl)acetamide derivatives ARCH PHARM. 2000; 333 (10): 337-340.

  1. Yamaguchi T, Ito S, Iwase Y, Watanabe K, Harano K.: Products from a novel reaction of dihydropyrazines with vichinaldiamines HETEROCYCLES. 1999; 51 (10): 2305-2309.

  2. Yamaguchi T, Eto M, Harano K, Kashige N, Watanabe K, Ito S.: New compounds derived from dihydropyrazines having DNA strand-breakage activity TETRAHEDRON. 1999; 55 (3): 675-686.

  1. Fujisawa S, Kadoma Y, Ito S: DSC and NMR spectroscopic studies of the interaction between Camphorated phenol and phospholipid liposomes DENT MATER J. 1998; 17 (4): 314-320.

  1. Ito S, Fujisawa S: Complete C-13 NMR assignment of the dental adhesive monomer 4-methacryloyloxyethyl trimellitate anhydride and its hydrate MAGN RESON CHEM. 1997; 35 (3): 213-214.

  1. Sekine H, Ito S, Nakahara Y, Suzuki S: Smoking abuse of Methanphetamine Mixed with Tabacco. Thermal properties of N-cyanomethylmethamphetamine and its degradation in plasma and aqueous media, Japanese Journal Toxycology and Enviromental Health. 1996; 42 (3): 223-235.

  1. Ohsaki A, Yan LT, Ito S, Edatsugi H, Iwata D, Komoda Y.: The isolation and in-vivo potent antitumor-activity of clerodane diterpenoid from the Oleoresin of the Brazilian medical plant, Copaifera-Langsdorfii Desfon BIOORG MED CHEM LETT. 1994; 4 (24): 2889-2892.

  1. Ito S, Ando S, Yamaguchi K, Funayama N, Yamamoto T, Kuroiwa Y, Kubota T, Komoda Y.: Preparation and evaluation of the antiaggregating and vasodilating activities of the novel 3-nitro-4(3H)-quinazolone derivatives BIOORG MED CHEM LETT. 1993; 3 (4): 611-614.

  1. Ito S, Yamaguchi K, Komoda Y: Structural confirmation of the nitration product of the 1(2H)-phthalazinone as the 2-Nitro-1(2H)- phthalazinone CHEM PHARM BULL. 1992; 40 (12): 3327-3329.

  1. Ito S, Azuma H, Funayama N, Kubota T, Sekizaki-Ohyama S, Ishikawa M: Studies on Vasoactive Compounds.III. Preparation and Antiaggregating Activitys of 1-Acetoxyphthalazine Derivatives and 2-methylsulfonyl-1(2H)-phthalazone derivatives Report Inst. Med. Dent. Engin.. 1990; 24 41-48.

  1. AZUMA H, SUGIMOTO-TOKUSHIMA M, TANAKA K, IKENOUE Y, ITO S, ISHIKAWA M: ALPHA-1-ADRENOCEPTOR ANTAGONIST ACTIVITY OF NOVEL PYRIMIDINE-DERIVATIVES (SHI437 AND IK29) IN RABBIT AORTA AND TRIGONE OF THE BLADDER BRIT J PHARMACOL. 1989; 96 (4): 1000-1006.

  1. ITO S, KOMODA Y, SEKIZAKI S, AZUMA H, ISHIKAWA M.: STUDIES ON VASOACTIVE HETEROCYCLIC-COMPOUNDS - PREPARATION AND EVALUATION OF THE HYPOTENSIVE AND ANTIAGGREGATING ACTIVITIES OF PHTHALAZINOL NITRATES CHEM PHARM BULL. 1988; 36 (7): (7): 2669-2672.

  1. SUGIMOTO A, TANAKA H, EGUCHI Y, ITO S, TAKASHIMA Y, ISHIKAWA M.: 7-(ETHOXYCARBONYL)-6,8-DIMETHYL-2-PHENYL-1(2H)-PHTHALAZINONE DERIVATIVES - SYNTHESIS AND INHIBITORY EFFECTS ON PLATELET-AGGREGATION J MED CHEM. 1984; 27 (10): 1300-1305.

  2. SUGIMOTO A, ITO S, EGUCHI Y, TANAKA H, TAKASHIMA Y, ISHIKAWA M.: SYNTHESIS AND INHIBITORY EFFECTS ON PLATELET-AGGREGATION OF PHTHALAZINONE DERIVATIVES EUR J MED CHEM. 1984; 19 (3): 223-228.

  1. AZUMA H, TAKASHIMA Y, KATSUURA Y, et al.: PHARMACOLOGICAL PROPERTIES OF A NOVEL QUINAZOLINONE DERIVATIVE, 3-(2-CHLOROPHENYL)-6-ETHOXYCARBONYL-5,7-DIMETHYL-2-(N-METHYLCARBAMOYLOXYMETHYL)-4(3H)-QUINAZOLINONE (EG1088) - MECHANISM OF VASODILATING ACTION J PHARMACOBIO-DYNAM. 1983; 6 (3): (3): S58.

  1. ISHIKAWA M, AZUMA H, EGUCHI Y, SUGIMOTO A, ITO S, TAKASHIMA Y, EBISAWA H, MORIGUVHI, KOTOKU I, SUZUKI H: NEW HYPOTENSIVE AGENTS CHEM PHARM BULL. 1982; 30 (2): 744-749.

  2. ISHIKAWA M, AZUMA H, EGUCHI Y, ITO S, TAKASHIMA Y, EBISAWA H, MORIGUVHI S, NAITO T, KOTOKU I: STRUCTURE-ACTIVITY-RELATIONSHIPS AND PHARMACOLOGICAL PROPERTIES OF A NEW HYPOTENSIVE AGENT (EG-1088) J PHARMACOBIO-DYNAM. 1982; 5 (4): S55.

  1. MAEDA M, ITO S, KOJIMA M: 1-2 MOLAR ADDUCTS IN REACTION OF 5-PHENYLTHIAZOLE AND DIMETHYL ACETYLENEDICARBOXYLATE TETRAHEDRON LETT. 1976; 38 3463-3466.

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