1. Tamara A M Chessa, Piotr Jung, Arqum Anwar, Sabine Suire, Karen E Anderson, David Barneda, Anna Kielkowska, Barzan A Sadiq, Ieng Wai Lai, Sergio Felisbino, Daniel J Turnham, Helen B Pearson, Wayne A Phillips, Junko Sasaki, Takehiko Sasaki, David Oxley, Dominik Spensberger, Anne Segonds-Pichon, Michael Wilson, Simon Walker, Hanneke Okkenhaug, Sabina Cosulich, Phillip T Hawkins, Len R Stephens: PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate. Mol Cell. 2023.08; 83 (16): 2991-3009.e13. ( PubMed , DOI )

  2. Dang Minh Tran, Nozomu Yoshioka, Norihisa Bizen, Yukiko Mori-Ochiai, Masato Yano, Shogo Yanai, Junya Hasegawa, Satoshi Miyashita, Mikio Hoshino, Junko Sasaki, Takehiko Sasaki, Hirohide Takebayashi: Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity. Dis Model Mech. 2023.07; 16 (7): ( PubMed , DOI )

  3. Yuki Kugii, Yui Kuroki, Yasushi Hara, Ryo Goitsuka, Naoko Nakano: Lack of Herpes Virus Entry Mediator Signals in Thymocytes Impairs Conventional CD8 T Cell Selection and Promotes Memory-like CD8 T Cell Development. The Journal of Immunology. 2023.05; 210 (10): 1482-1493. ( PubMed , DOI )

  4. Akihiro Iguchi, Sho Takatori, Shingo Kimura, Hiroki Muneto, Kai Wang, Hayato Etani, Genta Ito, Haruaki Sato, Yukiko Hori, Junko Sasaki, Takashi Saito, Takaomi C Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomita: INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model. iScience. 2023.04; 26 (4): 106375. ( PubMed , DOI )

  5. Yusuke Kiyoki, Takayasu Kato, Sakura Kito, Takashi Matsuzaka, Shin Morioka, Junko Sasaki, Kenichi Makishima, Tatsuhiro Sakamoto, Hidekazu Nishikii, Naoshi Obara, Mamiko Sakata-Yanagimoto, Takehiko Sasaki, Hitoshi Shimano, Shigeru Chiba: The fatty acid elongase Elovl6 is crucial for hematopoietic stem cell engraftment and leukemia propagation. Leukemia. 2023.03; ( PubMed , DOI )

  6. Takahito Miyake, Yuichi Inoue, Xinyan Shao, Takehito Seta, Yuto Aoki, Khanh Tien Nguyen Pham, Yuichi Shichino, Junko Sasaki, Takehiko Sasaki, Masahito Ikawa, Yoshiaki Yamaguchi, Hitoshi Okamura, Shintaro Iwasaki, Masao Doi: Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm. Cell Rep. 2023.02; 112157. ( PubMed , DOI )

  1. Tomonori Ayukawa, Masakazu Akiyama, Yasukazu Hozumi, Kenta Ishimoto, Junko Sasaki, Haruki Senoo, Takehiko Sasaki, Masakazu Yamazaki: Tissue flow regulates planar cell polarity independently of the Frizzled core pathway. Cell Rep. 2022.09; 40 (12): 111388. ( PubMed , DOI )

  2. Oe Y, Kakuda K, Yoshimura SI, Hara N, Hasegawa J, Terawaki S, Kimura Y, Ikenaka K, Suetsugu S, Mochizuki H, Yoshimori T, Nakamura S: PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy. PLoS genetics. 2022.06; 18 (6): e1010264. ( PubMed , DOI )

  3. Hasegawa J, Tokuda E, Yao Y, Sasaki T, Inoki K, Weisman LS: PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity. Molecular biology of the cell. 2022.03; 33 (3): ar26. ( PubMed , DOI )

  4. Morioka S, Nakanishi H, Yamamoto T, Hasegawa J, Tokuda E, Hikita T, Sakihara T, Kugii Y, Oneyama C, Yamazaki M, Suzuki A, Sasaki J, Sasaki T: A mass spectrometric method for in-depth profiling of phosphoinositide regioisomers and their disease-associated regulation. Nature communications. 2022.01; 13 (1): 83. ( PubMed , DOI )

  5. Asami Kawasaki, Akiko Sakai, Hiroki Nakanishi, Junya Hasegawa, Tomohiko Taguchi, Junko Sasaki, Hiroyuki Arai, Takehiko Sasaki, Michihiro Igarashi, Fubito Nakatsu: PI4P/PS countertransport by ORP10 at ER-endosome membrane contact sites regulates endosome fission. J Cell Biol. 2022.01; 221 (1): ( PubMed , DOI )

  1. Huang M, Koizumi A, Narita S, Nakanishi H, Sato H, Kashima S, Nara T, Kanda S, Numakura K, Saito M, Satoh S, Nanjo H, Sasaki T, Habuchi T: Altering phosphoinositides in high-fat diet-associated prostate tumor xenograft growth. MedComm. 2021.12; 2 (4): 756-764. ( PubMed , DOI )

  2. Sakihara T, Takiguchi N, Uzawa H, Serizawa R, Kobayashi T: Erylysin A inhibits cytokinesis in Escherichia coli by binding with cardiolipin. Journal of biochemistry. 2021.10; 170 (3): 369-377. ( PubMed , DOI )

  3. Sakihara Tomoko, Takiguchi Naoko, Uzawa Hikari, Serizawa Rika, Kobayashi Tetsuyuki: Erylysin A inhibits cytokinesis in Escherichia coli by binding with cardiolipin(和訳中) The Journal of Biochemistry. 2021.09; 170 (3): 369-377. ( ichushi )

  4. Daiki Hashimoto, Tsuyoshi Hirashima, Hisao Yamamura, Tomoya Kataoka, Kota Fujimoto, Taiju Hyuga, Atsushi Yoshiki, Kazunori Kimura, Shunsuke Kuroki, Makoto Tachibana, Kentaro Suzuki, Nobuhiko Yamamoto, Shin Morioka, Takehiko Sasaki, Gen Yamada: Dynamic erectile responses of a novel penile organ model utilizing two photon excitation microscopy (TPEM)†. Biology of reproduction. 2021.01; ( PubMed , DOI )

  5. Hasegawa J, Uchida Y, Mukai K, Lee S, Matsudaira T, Taguchi T: A Role of Phosphatidylserine in the Function of Recycling Endosomes. Frontiers in cell and developmental biology. 2021; 9 783857. ( PubMed , DOI )

  1. Nishio Miki, To Yoko, Maehama Tomohiko, Aono Yukari, Otani Junji, Hikasa Hiroki, Kitagawa Akihiro, Mimori Koshi, Sasaki Takehiko, Nishina Hiroshi, Toyokuni Shinya, Lydon John P., Nakao Kazuwa, Mak Tak Wah, Kiyono Tohru, Katabuchi Hidetaka, Tashiro Hironori, Suzuki Akira: Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice(和訳中) Cancer Science. 2020.10; 111 (10): 3576-3587. ( ichushi )

  2. Yamamoto Eiji, Sasaki Junko, Sasaki Takehiko, Sansom Mark S. P.: Effect of lipid quality on the association of membrane bound proteins with phosphoinositidecontaining membranes(和訳中) 生物物理. 2020.08; 60 (Suppl.1-2): S225. ( ichushi )

  3. Nishio M, To Y, Maehama T, Aono Y, Otani J, Hikasa H, Kitagawa A, Mimori K, Sasaki T, Nishina H, Toyokuni S, Lydon JP, Nakao K, Wah Mak T, Kiyono T, Katabuchi H, Tashiro H, Suzuki A: Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice. Cancer science. 2020.07; 111 (10): 3576-3587. ( PubMed , DOI )

  1. Fujioka Yoichiro, Satoh Aya O., Horiuchi Kosui, Fujioka Mari, Tsutsumi Kaori, Sasaki Junko, Nepal Prabha, Kashiwagi Sayaka, Paudel Sarad, Nishide Shinya, Nanbo Asuka, Sasaki Takehiko, Ohba Yusuke: A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection(和訳中) Cell Structure and Function. 2019.12; 44 (1-2): 61-74. ( ichushi )

  2. 1. Kawai T, Miyata H, Nakanishi H, Sakata S, Morioka S, Sasaki J, Watanabe M, Sakimura K, Fujimoto T, Sasaki T, Ikawa M & Okamura Y.: PtdIns(4,5)P2 Distribution Mediated by a Voltage-Sensing Phosphatase (VSP) Regulates Sperm Motility. Proc. Natl. Acad. Sci. USA. 2019.12; 116 (51): 26020-26028. ( DOI )

  3. Kawai T, Miyata H, Nakanishi H, Sakata S, Morioka S, Sasaki J, Watanabe M, Sakimura K, Fujimoto T, Sasaki T, Ikawa M, Okamura Y: Polarized PtdIns(4,5)P2 distribution mediated by a voltage-sensing phosphatase (VSP) regulates sperm motility. Proceedings of the National Academy of Sciences of the United States of America. 2019.11; ( PubMed , DOI )

  4. 成田 伸太郎, 中西 広樹, 松田 芳教, 小泉 淳, 江口 賢史, 高須賀 俊輔, 黄 明国, 井上 高光, 佐々木 純子, 南条 博, 羽渕 友則, 佐々木 雄彦: 腎癌におけるイノシトールリン脂質発現プロファイル(The expression profile of phosphatidylinositol phosphates in clinical renal cell carcinoma) 日本癌学会総会記事. 2019.09; 78回 P-1154. ( ichushi )

  5. McCormick Barry, Craig Helen E., Chu Julia Y., Carlin Leo M., Canel Marta, Wollweber Florian, Toivakka Matilda, Michael Melina, Astier Anne L., Norton Laura, Lilja Johanna, Felton Jennifer M., Sasaki Takehiko, Ivaska Johanna, Hers Ingeborg, Dransfield Ian, Rossi Adriano G., Vermeren Sonja: A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites JOURNAL OF IMMUNOLOGY. 2019.09; 203 (6): 1579-1588. ( PubMed , DOI )

  6. Koizumi Atsushi, Narita Shintaro, Nakanishi Hiroki, Ishikawa Masaki, Eguchi Satoshi, Kimura Hirotaka, Takasuga Shunsuke, Huang Mingguo, Inoue Takamitsu, Sasaki Junko, Yoshioka Toshiaki, Habuchi Tomonori, Sasaki Takehiko: Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression SCIENTIFIC REPORTS. 2019.09; 9 (1): 13257. ( PubMed , DOI )

  7. Hasegawa J, Imen J, Yamamoto H, Tsujita K, Tokuda E, Shibata H, Maki M, Itoh T: SH3YL1 cooperates with ESCRT-I in the sorting and degradation of the EGF receptor. Journal of cell science. 2019.09; ( PubMed , DOI )

  8. Koizumi A, Narita S, Nakanishi H, Ishikawa M, Eguchi S, Kimura H, Takasuga S, Huang M, Inoue T, Sasaki J, Yoshioka T, Habuchi T & Sasaki T.: Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression. Sci Rep. 2019.09; 9 (1): 13257. ( DOI )

  9. Sasaki Junko, Eguchi Satoshi, Nakanishi Hiroki, Sasaki Takehiko: Regulation of cell functions by phosphoinositides　Molecular mechanisms of phosphoinositide signaling(和訳中) The Journal of Physiological Sciences. 2019.06; 69 (Suppl.1): S36. ( ichushi )

  10. Kawai Takafumi, Miyata Haruhiko, Nakanishi Hiroki, Sakata Souhei, Okochi Yoshifumi, Watanabe Masahiko, Sakimura Kenji, Sasaki Takehiko, Ikawa Masahito, Okamura Yasushi: Regulation of cell functions by phosphoinositides　Functional analysis of voltage-sensing phosphatase in mouse sperm(和訳中) The Journal of Physiological Sciences. 2019.06; 69 (Suppl.1): S36. ( ichushi )

  11. Fujioka Y, Satoh AO, Horiuchi K, Fujioka M, Tsutsumi K, Sasaki J, Nepal P, Kashiwagi S, Paudel S, Nishide S, Nanbo A, Sasaki T, Ohba Y: A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection. Cell structure and function. 2019.04; 44 (1): 61-74. ( PubMed , DOI )

  12. Takemasu S, Ito M, Morioka S, Nigorikawa K, Kofuji S, Takasuga S, Eguchi S, Nakanishi H, Matsuoka I, Sasaki J, Sasaki T, Hazeki K: Lysophosphatidylinositol-acyltransferase-1 is involved in cytosolic Ca2+ oscillations in macrophages. Genes to cells : devoted to molecular & cellular mechanisms. 2019.03; ( PubMed , DOI )

  13. Takemasu Shinya、Ito Masaki、Morioka Shin、Nigorikawa Kiyomi、Kofuji Satoshi、Takasuga Shunsuke、Eguchi Satoshi、Nakanishi Hiroki、Matsuoka Isao、Sasaki Junko、Sasaki Takehiko、 Hazeki Kaoru: Lysophosphatidylinositol-acyltransferase-1 is involved in cytosolic Ca2+ oscillations in macrophages. Genes to Cells. 2019.03; 24 (5): 366-376. ( DOI )

  14. Miki Nishio, Yousuke Miyachi, Junji Otani, Shoji Tane, Hirofumi Omori, Fumihito Ueda, Hideru Togashi, Takehiko Sasaki, Tak Wah Mak, Kazuwa Nakao, Yasuyuki Fujita, Hiroshi Nishina, Tomohiko Maehama, Akira Suzuki: Hippo pathway controls cell adhesion and context-dependent cell competition to influence skin engraftment efficiency. FASEB J.. 2019.01; 33 (4): fj201802005R. ( PubMed , DOI )

  15. Fujioka Yoichiro, Satoh Aya O., Horiuchi Kosui, Fujioka Mari, Tsutsumi Kaori, Sasaki Junko, Nepal Prabha, Kashiwagi Sayaka, Paudel Sarad, Nishide Shinya, Nanbo Asuka, Sasaki Takehiko, Ohba Yusuke: A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection CELL STRUCTURE AND FUNCTION. 2019; 44 (1): 61-74.

  1. 小泉 淳, 成田 伸太郎, 中西 広樹, 奈良 健平, 神田 壮平, 沼倉 一幸, 黄 明国, 齋藤 満, 井上 高光, 佐藤 滋, 吉岡 年明, 羽渕 友則, 佐々木 雄彦: 前立腺癌におけるホスファチジルイノシトールリン酸プロファイルの解析(Phosphatidylinositol phosphate profiles in pre-clinical and clinical prostate cancer) 日本癌学会総会記事. 2018.09; 77回 1444. ( ichushi )

  2. Hirotaka Kimura, Yasushi Matsuyama, Sachiko Araki, Atsushi Koizumi, Yumi Kariya, Shunsuke Takasuga, Satoshi Eguchi, Hiroki Nakanishi, Junko Sasaki, Takehiko Sasaki: The effect and possible clinical efficacy of in vivo inhibition of neutrophil extracellular traps by blockade of PI3K-gamma on the pathogenesis of microscopic polyangiitis. Mod Rheumatol. 2018.05; 28 (3): 530-541. ( PubMed , DOI )

  3. Marc C Liggins, Jessica L Flesher, Sohail Jahid, Priya Vasudeva, Victoria Eby, Shunsuke Takasuga, Junko Sasaki, Takehiko Sasaki, Raymond E Boissy, Anand K Ganesan: PIKfyve regulates melanosome biogenesis. PLoS Genet.. 2018.05; 14 (3): e1007290. ( PubMed , DOI )

  4. Kimura Hirotaka, Matsuyama Yasushi, Araki Sachiko, Koizumi Atsushi, Kariya Yumi, Takasuga Shunsuke, Eguchi Satoshi, Nakanishi Hiroki, Sasaki Junko, Sasaki Takehiko: 顕微鏡的多発血管炎の病因に対するPI3K-ガンマの遮断による好中球細胞外トラップのin vivo阻害の影響と潜在的な臨床作用(The effect and possible clinical efficacy of in vivo inhibition of neutrophil extracellular traps by blockade of PI3K-gamma on the pathogenesis of microscopic polyangiitis) Modern Rheumatology. 2018.05; 28 (3): 530-541. ( ichushi )

  5. Hideki Makinoshima, Shigeki Umemura, Ayako Suzuki, Hiroki Nakanishi, Ami Maruyama, Hibiki Udagawa, Sachiyo Mimaki, Shingo Matsumoto, Seiji Niho, Genichiro Ishii, Masahiro Tsuboi, Atsushi Ochiai, Hiroyasu Esumi, Takehiko Sasaki, Koichi Goto, Katsuya Tsuchihara: Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung Carcinoma. Cancer Res.. 2018.05; 78 (9): 2179-2190. ( PubMed , DOI )

  6. Shin Morioka, Kiyomi Nigorikawa, Eri Okada, Yoshimasa Tanaka, Yoshihiro Kasuu, Miho Yamada, Satoshi Kofuji, Shunsuke Takasuga, Hiroki Nakanishi, Takehiko Sasaki, Kaoru Hazeki: TMEM55a localizes to macrophage phagosomes to downregulate phagocytosis. J. Cell. Sci.. 2018.03; 131 (5): ( PubMed , DOI )

  7. Fei Yang, Lingli Yang, Mari Wataya-Kaneda, Junya Hasegawa, Tamotsu Yoshimori, Atsushi Tanemura, Daisuke Tsuruta, Ichiro Katayama: Dysregulation of autophagy in melanocytes contributes to hypopigmented macules in tuberous sclerosis complex. J. Dermatol. Sci.. 2018.02; 89 (2): 155-164. ( PubMed , DOI )

  1. Ismael Al-Ramahi, Sai Srinivas Panapakkam Giridharan, Yu-Chi Chen, Samarjit Patnaik, Nathaniel Safren, Junya Hasegawa, Maria de Haro, Amanda K Wagner Gee, Steven A Titus, Hyunkyung Jeong, Jonathan Clarke, Dimitri Krainc, Wei Zheng, Robin F Irvine, Sami Barmada, Marc Ferrer, Noel Southall, Lois S Weisman, Juan Botas, Juan Jose Marugan: Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein. Elife. 2017.12; 6 ( PubMed , DOI )

  2. Mingguo Huang, Shintaro Narita, Takamitsu Inoue, Atsushi Koizumi, Mitsuru Saito, Hiroshi Tsuruta, Kazuyuki Numakura, Shigeru Satoh, Hiroshi Nanjo, Takehiko Sasaki, Tomonori Habuchi: Fatty acid binding protein 4 enhances prostate cancer progression by upregulating matrix metalloproteinases and stromal cell cytokine production. Oncotarget. 2017.12; 8 (67): 111780-111794. ( PubMed , DOI )

  3. Mouhannad Malek, Anna Kielkowska, Tamara Chessa, Karen E Anderson, David Barneda, Pınar Pir, Hiroki Nakanishi, Satoshi Eguchi, Atsushi Koizumi, Junko Sasaki, Véronique Juvin, Vladimir Y Kiselev, Izabella Niewczas, Alexander Gray, Alexandre Valayer, Dominik Spensberger, Marine Imbert, Sergio Felisbino, Tomonori Habuchi, Soren Beinke, Sabina Cosulich, Nicolas Le Novère, Takehiko Sasaki, Jonathan Clark, Phillip T Hawkins, Len R Stephens: PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K. Mol. Cell. 2017.11; 68 (3): 566-580.e10. ( PubMed , DOI )

  4. Tatsuyuki Matsudaira, Kojiro Mukai, Taishin Noguchi, Junya Hasegawa, Tomohisa Hatta, Shun-Ichiro Iemura, Tohru Natsume, Norio Miyamura, Hiroshi Nishina, Jun Nakayama, Kentaro Semba, Takuya Tomita, Shigeo Murata, Hiroyuki Arai, Tomohiko Taguchi: Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells. Nat Commun. 2017.11; 8 (1): 1246. ( PubMed , DOI )

  5. Tagawa Hiroyuki, Abe Fumito, Nakanishi Hiroki, Kitadate Akihiro, Ikeda Sho, Takahashi Naoto, Sasaki Takehiko: 脂質定量解析による悪性リンパ腫の新たな診断マーカーの同定(Phosphatidylinositol phosphates profile reveals novel diagnostic marker(s) in malignant lymphoma) 臨床血液. 2017.09; 58 (9): 1742. ( ichushi )

  6. 阿部 史人, 中西 広樹, 北舘 明宏, 池田 翔, 亀岡 吉弘, 高橋 直人, 佐々木 雄彦, 田川 博之: 悪性リンパ腫におけるイノシトールリン脂質プロファイル 日本癌学会総会記事. 2017.09; 76回 P-2236. ( ichushi )

  7. Yoshiko Iizuka-Hishikawa, Daisuke Hishikawa, Junko Sasaki, Keiyo Takubo, Motohito Goto, Katsuyuki Nagata, Hiroki Nakanishi, Hideo Shindou, Tadashi Okamura, Chizuru Ito, Kiyotaka Toshimori, Takehiko Sasaki, Takao Shimizu: Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis. J. Biol. Chem.. 2017.07; 292 (29): 12065-12076. ( PubMed , DOI )

  8. Hideo Shindou, Hideto Koso, Junko Sasaki, Hiroki Nakanishi, Hiroshi Sagara, Koh M Nakagawa, Yoshikazu Takahashi, Daisuke Hishikawa, Yoshiko Iizuka-Hishikawa, Fuyuki Tokumasu, Hiroshi Noguchi, Sumiko Watanabe, Takehiko Sasaki, Takao Shimizu: Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells. J. Biol. Chem.. 2017.07; 292 (29): 12054-12064. ( PubMed , DOI )

  9. K Otsubo, H Goto, M Nishio, K Kawamura, S Yanagi, W Nishie, T Sasaki, T Maehama, H Nishina, K Mimori, T Nakano, H Shimizu, T W Mak, K Nakao, Y Nakanishi, A Suzuki: MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation. Oncogene. 2017.07; 36 (29): 4201-4211. ( PubMed , DOI )

  10. Junya Hasegawa, Bethany S Strunk, Lois S Weisman: PI5P and PI(3,5)P2; Minor, but Essential Phosphoinositides. Cell Struct. Funct.. 2017.05; 42 (1): 49-60. ( PubMed , DOI )

  11. 黄 明国, 小泉 淳, 井上 高光, 成田 伸太郎, 斉藤 満, 佐藤 滋, 南條 博, 佐々木 雄彦, 羽渕 友則: 高脂肪食下前立腺間質　癌微小環境の活性化と前立腺癌進展における脂肪酸結合分子4(FABP4)の役割 日本泌尿器科学会総会. 2017.04; 105回 OP41-4. ( ichushi )

  12. Matsumoto J, Nakanishi H, Kunii Y, Sugiura Y, Yuki D, Wada A, Hino M, Niwa SI, Kondo T, Waki M, Hayasaka T, Masaki N, Akatsu H, Hashizume Y, Yamamoto S, Sato S, Sasaki T, Setou M, Yabe H: Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia. Scientific reports. 2017.03; 7 45050. ( PubMed , DOI )

  13. Hirotaka Kimura, Satoshi Eguchi, Junko Sasaki, Keiji Kuba, Hiroki Nakanishi, Shunsuke Takasuga, Masakazu Yamazaki, Akiteru Goto, Hiroyuki Watanabe, Hiroshi Itoh, Yumiko Imai, Akira Suzuki, Noboru Mizushima, Takehiko Sasaki: Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy. JCI Insight. 2017.01; 2 (1): e89462. ( PubMed , DOI )

  1. Shuhei Nakamura, Junya Hasegawa, Tamotsu Yoshimori: Regulation of lysosomal phosphoinositide balance by INPP5E is essential for autophagosome-lysosome fusion. Autophagy. 2016.12; 12 (12): 2500-2501. ( PubMed , DOI )

  2. Junya Hasegawa, Ryo Iwamoto, Takanobu Otomo, Akiko Nezu, Maho Hamasaki, Tamotsu Yoshimori: Autophagosome-lysosome fusion in neurons requires INPP5E, a protein associated with Joubert syndrome. EMBO J.. 2016.09; 35 (17): 1853-1867. ( PubMed , DOI )

  3. Shin Morioka, Kiyomi Nigorikawa, Junko Sasaki, Kaoru Hazeki, Yoshihiro Kasuu, Takehiko Sasaki, Osamu Hazeki: Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model. Innate Immun. 2016.08; 22 (6): 444-451. ( PubMed , DOI )

  4. Miki Nishio, Keishi Sugimachi, Hiroki Goto, Jia Wang, Takumi Morikawa, Yosuke Miyachi, Yusuke Takano, Hiroki Hikasa, Tohru Itoh, Satoshi O Suzuki, Hiroki Kurihara, Shinichi Aishima, Andrew Leask, Takehiko Sasaki, Toru Nakano, Hiroshi Nishina, Yuji Nishikawa, Yoshitaka Sekido, Kazuwa Nakao, Kazuo Shin-Ya, Koshi Mimori, Akira Suzuki: Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice. Proc. Natl. Acad. Sci. U.S.A.. 2016.01; 113 (1): E71-E80. ( PubMed , DOI )

  5. Localizing the lipid products of PI3Kγ in neutrophils. Advances in biological regulation. 2016.01; 60 36-45. ( PubMed , DOI )

  1. Kiyomi Nigorikawa, Kaoru Hazeki, Junko Sasaki, Yumio Omori, Mikiko Miyake, Shin Morioka, Ying Guo, Takehiko Sasaki, Osamu Hazeki: Inositol Polyphosphate-4-Phosphatase Type I Negatively Regulates Phagocytosis via Dephosphorylation of Phagosomal PtdIns(3,4)P2. PLoS ONE. 2015.11; 10 (11): e0142091. ( PubMed , DOI )

  2. Chen Li Chew, Andrea Lunardi, Federico Gulluni, Daniel T Ruan, Ming Chen, Leonardo Salmena, Michiya Nishino, Antonella Papa, Christopher Ng, Jacqueline Fung, John G Clohessy, Junko Sasaki, Takehiko Sasaki, Roderick T Bronson, Emilio Hirsch, Pier Paolo Pandolfi: In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes. Cancer Discov. 2015.07; 5 (7): 740-751. ( PubMed , DOI )

  3. Satoshi Kofuji, Hirotaka Kimura, Hiroki Nakanishi, Hiroshi Nanjo, Shunsuke Takasuga, Hui Liu, Satoshi Eguchi, Ryotaro Nakamura, Reietsu Itoh, Noriko Ueno, Ken Asanuma, Mingguo Huang, Atsushi Koizumi, Tomonori Habuchi, Masakazu Yamazaki, Akira Suzuki, Junko Sasaki, Takehiko Sasaki: INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor. Cancer Discov. 2015.07; 5 (7): 730-739. ( PubMed , DOI )

  4. Laura R H Ip, George Poulogiannis, Felipe Cia Viciano, Junko Sasaki, Satoshi Kofuji, Victoria J Spanswick, Daniel Hochhauser, John A Hartley, Takehiko Sasaki, Christina A Gewinner: Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment. Oncotarget. 2015.04; 6 (12): 10548-10562. ( PubMed , DOI )

  5. Junya Hasegawa, Ikuko Maejima, Ryo Iwamoto, Tamotsu Yoshimori: Selective autophagy: lysophagy. Methods. 2015.03; 75 128-132. ( PubMed , DOI )

  6. Gerald R V Hammond, Shunsuke Takasuga, Takehiko Sasaki, Tamas Balla: The ML1Nx2 Phosphatidylinositol 3,5-Bisphosphate Probe Shows Poor Selectivity in Cells. PLoS ONE. 2015; 10 (10): e0139957. ( PubMed , DOI )

  1. Y. Fujioka, M. Tsuda, A. Nanbo, T. Hattori, J. Sasaki, T. Sasaki, T. Miyazaki, Y. Ohba: Calcium signaling mediated influenza virus entry into host cells. MOLECULAR BIOLOGY OF THE CELL. 2014.12; 25

  2. Y. Fujioka, M. Tsuda, A. Nanbo, T. Hattori, J. Sasaki, T. Sasaki, T. Miyazaki, Y. Ohba: Calcium signaling mediated influenza virus entry into host cells. MOLECULAR BIOLOGY OF THE CELL. 2014.12; 25

  3. Tomonori Ayukawa, Masakazu Akiyama, Jennifer L Mummery-Widmer, Thomas Stoeger, Junko Sasaki, Juergen A Knoblich, Haruki Senoo, Takehiko Sasaki, Masakazu Yamazaki: Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in Drosophila. Cell Rep. 2014.07; 8 (2): 610-621. ( PubMed , DOI )

  4. Emi Tokuda, Toshiki Itoh, Junya Hasegawa, Takeshi Ijuin, Yukiko Takeuchi, Yasuhiro Irino, Miki Fukumoto, Tadaomi Takenawa: Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion and invasive cell migration in human breast cancer. Cancer Res.. 2014.06; 74 (11): 3054-3066. ( PubMed , DOI )

  5. Mingguo Huang, Shintaro Narita, Takamitsu Inoue, Norihiko Tsuchiya, Shigeru Satoh, Hiroshi Nanjo, Takehiko Sasaki, Tomonori Habuchi: Diet-induced macrophage inhibitory cytokine 1 promotes prostate cancer progression ENDOCRINE-RELATED CANCER. 2014.02; 21 (1): 39-50. ( PubMed , DOI )

  6. Nakamura Ryotaro, Takasuga Shunsuke, Horie Yasuo, SASAKI Takehiko: ALTERATIONS IN INTESTINAL PERMEABILITY CAUSE COLONIC INFLAMMATION AND FIBROSIS IN TYPE Ⅲ PHOSPHATIDYLINOSITOL PHOSPHATE KINASE-DEFICIENT MICE 秋田医学. 2014; 41 (3): 129-135.

  1. Yoichiro Fujioka, Masumi Tsuda, Asuka Nanbo, Tomoe Hattori, Junko Sasaki, Takehiko Sasaki, Tadaaki Miyazaki, Yusuke Ohba: A Ca(2+)-dependent signalling circuit regulates influenza A virus internalization and infection. Nat Commun. 2013.11; 4 2763. ( PubMed , DOI )

  2. Yasuo Horie, Shunsuke Takasuga, Hirosato Mashima, Takehiko Sasaki, Hirohide Ohnishi: Epithelial Mesenchymal Transition in Intestinal Epithelia Based on the Loss of Pipkiii Kinase Activity Induces Intestinal Fibrosis in Enterocyte-Specific Pipk III Deficient Mice GASTROENTEROLOGY. 2013.05; 144 (5): S669.

  3. Kazuya Tsujita, Akihiro Kondo, Shusaku Kurisu, Junya Hasegawa, Toshiki Itoh, Tadaomi Takenawa: Antagonistic regulation of F-BAR protein assemblies controls actin polymerization during podosome formation. J. Cell. Sci.. 2013.05; 126 (Pt 10): 2267-2278. ( PubMed , DOI )

  4. Hideaki Morishita, Satoshi Eguchi, Hirotaka Kimura, Junko Sasaki, Yuriko Sakamaki, Michael L Robinson, Takehiko Sasaki, Noboru Mizushima: Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation. J. Biol. Chem.. 2013.04; 288 (16): 11436-11447. ( PubMed , DOI )

  5. Asanuma Ken, Takasuga Shunsuke, Sasaki Junko, Sasaki Takehiko: PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE IS AN ESSENTIAL REGULATOR OF LYSOSOME MORPHOLOGY 秋田医学. 2013.03; 39 (3): 129-137.

  6. Chida Shinsuke, Itoh Reietsu, Kofuji Satoshi, Eguchi Satoshi, Takasuga Shunsuke, Sasaki Junko, Sasaki Takehiko: SHIP1 DELETION ENHANCES ROS PRODUCTION AND DECREASES SURVIVAL OF THE S. AUREUS INFECTED MICE 秋田医学. 2013.03; 39 (3): 95-101.

  7. Toshiki Itoh, Junya Hasegawa: Mechanistic insights into the regulation of circular dorsal ruffle formation. J. Biochem.. 2013.01; 153 (1): 21-29. ( PubMed , DOI )

  8. Shunsuke Takasuga, Yasuo Horie, Junko Sasaki, Ge-Hong Sun-Wada, Nobuyuki Kawamura, Ryota Iizuka, Katsunori Mizuno, Satoshi Eguchi, Satoshi Kofuji, Hirotaka Kimura, Masakazu Yamazaki, Chihoko Horie, Eri Odanaga, Yoshiko Sato, Shinsuke Chida, Kenji Kontani, Akihiro Harada, Toshiaki Katada, Akira Suzuki, Yoh Wada, Hirohide Ohnishi, Takehiko Sasaki: Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc. Natl. Acad. Sci. U.S.A.. 2013.01; 110 (5): 1726-1731. ( PubMed , DOI )

  9. Essential role of class II phosphatidylinositol-3-kinase-C2α in sphingosine 1-phosphate receptor-1-mediated signaling and migration in endothelial cells. The Journal of biological chemistry. 2013.01; 288 (4): 2325-2339. ( PubMed , DOI )

  1. Hyeon-Cheol Lee, Takao Inoue, Junko Sasaki, Takuya Kubo, Shinji Matsuda, Yasuko Nakasaki, Mitsuharu Hattori, Fumiharu Tanaka, Osamu Udagawa, Nozomu Kono, Toshiki Itoh, Hideo Ogiso, Ryo Taguchi, Makoto Arita, Takehiko Sasaki, Hiroyuki Arai: LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice. Mol. Biol. Cell. 2012.12; 23 (24): 4689-4700. ( PubMed , DOI )

  2. Miki Nishio, Koichi Hamada, Kohichi Kawahara, Masato Sasaki, Fumihito Noguchi, Shuhei Chiba, Kensaku Mizuno, Satoshi O Suzuki, Youyi Dong, Masaaki Tokuda, Takumi Morikawa, Hiroki Hikasa, Jonathan Eggenschwiler, Norikazu Yabuta, Hiroshi Nojima, Kentaro Nakagawa, Yutaka Hata, Hiroshi Nishina, Koshi Mimori, Masaki Mori, Takehiko Sasaki, Tak W Mak, Toru Nakano, Satoshi Itami, Akira Suzuki: Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J. Clin. Invest.. 2012.12; 122 (12): 4505-4518. ( PubMed , DOI )

  3. Masahiro Shinohara, Masaki Nakamura, Hironari Masuda, Jun Hirose, Yuho Kadono, Mitsuyasu Iwasawa, Yuuichi Nagase, Kohjiro Ueki, Takashi Kadowaki, Takehiko Sasaki, Shigeaki Kato, Hiroaki Nakamura, Sakae Tanaka, Hiroshi Takayanagi: Class IA Phosphatidylinositol 3-Kinase Regulates Osteoclastic Bone Resorption Through Protein Kinase B-Mediated Vesicle Transport JOURNAL OF BONE AND MINERAL RESEARCH. 2012.12; 27 (12): 2464-2475. ( PubMed , DOI )

  4. G Gregory Neely, Shuan Rao, Michael Costigan, Norbert Mair, Ildiko Racz, Giedre Milinkeviciute, Arabella Meixner, Swetha Nayanala, Robert S Griffin, Inna Belfer, Feng Dai, Shad Smith, Luda Diatchenko, Stefano Marengo, Bernhard J Haubner, Maria Novatchkova, Dustin Gibson, William Maixner, J Andrew Pospisilik, Emilio Hirsch, Ian Q Whishaw, Andreas Zimmer, Vaijayanti Gupta, Junko Sasaki, Yasunori Kanaho, Takehiko Sasaki, Michaela Kress, Clifford J Woolf, Josef M Penninger: Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. PLoS Genet.. 2012.11; 8 (12): e1003071. ( PubMed , DOI )

  5. Kazuaki Yoshioka, Kotaro Yoshida, Hong Cui, Tomohiko Wakayama, Noriko Takuwa, Yasuo Okamoto, Wa Du, Xun Qi, Ken Asanuma, Kazushi Sugihara, Sho Aki, Hidekazu Miyazawa, Kuntal Biswas, Chisa Nagakura, Masaya Ueno, Shoichi Iseki, Robert J Schwartz, Hiroshi Okamoto, Takehiko Sasaki, Osamu Matsui, Masahide Asano, Ralf H Adams, Nobuyuki Takakura, Yoh Takuwa: Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function. Nat. Med.. 2012.10; 18 (10): 1560-1569. ( PubMed , DOI )

  6. Junya Hasegawa, Kazuya Tsujita, Tadaomi Takenawa, Toshiki Itoh: ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf5. Mol. Biol. Cell. 2012.07; 23 (13): 2481-2489. ( PubMed , DOI )

  7. Tatsuki Kurokawa, Shunsuke Takasuga, Souhei Sakata, Shinji Yamaguchi, Shigeo Horie, Koichi J Homma, Takehiko Sasaki, Yasushi Okamura: 3' Phosphatase activity toward phosphatidylinositol 3,4-bisphosphate [PI(3,4)P2] by voltage-sensing phosphatase (VSP). Proc. Natl. Acad. Sci. U.S.A.. 2012.06; 109 (25): 10089-10094. ( PubMed , DOI )

  8. Yasuo Horie, Shunsuke Takasuga, Takehiko Sasaki, Hirohide Ohnishi: Contribution of Intestinal Bacteria and Epithelial Mesenchymal Transition to Intestinal Inflammation and Fibrosis in Enterocyte-Specific Pipk III Deficient Mice GASTROENTEROLOGY. 2012.05; 142 (5): S689.

  9. Yasuhiro Irino, Emi Tokuda, Junya Hasegawa, Toshiki Itoh, Tadaomi Takenawa: Quantification and visualization of phosphoinositides by quantum dot-labeled specific binding-domain probes. J. Lipid Res.. 2012.04; 53 (4): 810-819. ( PubMed , DOI )

  10. Akira Suzuki, Ryunosuke Kogo, Kohichi Kawahara, Masato Sasaki, Miki Nishio, Tomohiko Maehama, Takehiko Sasaki, Koshi Mimori, Masaki Mori: A new PICTure of nucleolar stress CANCER SCIENCE. 2012.04; 103 (4): 632-637. ( PubMed , DOI )

  11. Rieko Imae, Takao Inoue, Yasuko Nakasaki, Yasunori Uchida, Yohsuke Ohba, Nozomu Kono, Hiroki Nakanishi, Takehiko Sasaki, Shohei Mitani, Hiroyuki Arai: LYCAT, a homologue of C. elegans acl-8, acl-9, and acl-10, determines the fatty acid composition of phosphatidylinositol in mice JOURNAL OF LIPID RESEARCH. 2012.03; 53 (3): 335-347. ( PubMed , DOI )

  12. Nobuyuki Kawamura, Ge-Hong Sun-Wada, Minako Aoyama, Akihiro Harada, Shunsuke Takasuga, Takehiko Sasaki, Yoh Wada: Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos. Nat Commun. 2012; 3 1071. ( PubMed , DOI )

  1. Yasuo Horie, Shunsuke Takasuga, Takehiko Sasaki, Hirohide Ohnishi: Functional Analysis of Phosphatidylinositol 3,5-Bisphosphate in Enterocytes Using Pipk III Deficient Mice DIGESTIVE DISEASES AND SCIENCES. 2011.10; 56 (10): 2769-2770.

  2. Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages. PloS one. 2011.10; 6 (10): ( PubMed , DOI )

  3. Yasunori Uchida, Junya Hasegawa, Daniel Chinnapen, Takao Inoue, Seiji Okazaki, Ryuichi Kato, Soichi Wakatsuki, Ryo Misaki, Masato Koike, Yasuo Uchiyama, Shun-ichiro Iemura, Tohru Natsume, Ryusuke Kuwahara, Takatoshi Nakagawa, Kiyotaka Nishikawa, Kojiro Mukai, Eiji Miyoshi, Naoyuki Taniguchi, David Sheff, Wayne I Lencer, Tomohiko Taguchi, Hiroyuki Arai: Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes. Proc. Natl. Acad. Sci. U.S.A.. 2011.09; 108 (38): 15846-15851. ( PubMed , DOI )

  4. Masato Sasaki, Kohichi Kawahara, Miki Nishio, Koshi Mimori, Ryunosuke Kogo, Koichi Hamada, Bunsho Itoh, Jia Wang, Yukako Komatsu, Yong Ryoul Yang, Hiroki Hikasa, Yasuo Horie, Takayuki Yamashita, Takehiko Kamijo, Yanping Zhang, Yan Zhu, Carol Prives, Toru Nakano, Tak Wah Mak, Takehiko Sasaki, Tomohiko Maehama, Masaki Mori, Akira Suzuki: Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat. Med.. 2011.07; 17 (8): 944-951. ( PubMed , DOI )

  5. Yasuo Horie, Shunsuke Takasuga, Takehiko Sasaki, Hirohide Ohnishi: Analysis of Intestinal Inflammation and Fibrosis Based on Impaired Production of Phosphatidylinositol 3,5-Bisphosphate on Enterocytes Using Type III Phosphatidylinositol Phosphate Kinase Deficient Mice GASTROENTEROLOGY. 2011.05; 140 (5): S85.

  6. Junya Hasegawa, Emi Tokuda, Takeshi Tenno, Kazuya Tsujita, Haruko Sawai, Hidekazu Hiroaki, Tadaomi Takenawa, Toshiki Itoh: SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain. J. Cell Biol.. 2011.05; 193 (5): 901-916. ( PubMed , DOI )

  7. Naoki Kobayashi, Kohjiro Ueki, Yukiko Okazaki, Aya Iwane, Naoto Kubota, Mitsuru Ohsugi, Motoharu Awazawa, Masatoshi Kobayashi, Takayoshi Sasako, Kazuma Kaneko, Miho Suzuki, Yoshitaka Nishikawa, Kazuo Hara, Kotaro Yoshimura, Isao Koshima, Susumu Goyama, Koji Murakami, Junko Sasaki, Ryozo Nagai, Mineo Kurokawa, Takehiko Sasaki, Takashi Kadowaki: Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance. Proc. Natl. Acad. Sci. U.S.A.. 2011.04; 108 (14): 5753-5758. ( PubMed , DOI )

  8. Yoichiro Fujioka, Masumi Tsuda, Tomoe Hattori, Junko Sasaki, Takehiko Sasaki, Tadaaki Miyazaki, Yusuke Ohba: The Ras-PI3K signaling pathway is involved in clathrin-independent endocytosis and the internalization of influenza viruses. PLoS ONE. 2011.01; 6 (1): e16324. ( PubMed , DOI )

  9. Nobukatsu Kinoshita, Yasuo Horie, Shigetoshi Ohshima, Yohei Hirai, Takahiro Dohmen, Mario Jin, Tamotsu Matsuhashi, Junko Sasaki, Takehiko Sasaki, Masahiro Iizuka, Hirohide Ohnishi: Epimorphin protects hepatocytes from oxidative stress by inhibiting mitochondrial injury. J. Gastroenterol. Hepatol.. 2011.01; 26 (1): 201-206. ( PubMed , DOI )

  1. Laura A Volpicelli-Daley, Louise Lucast, Liang-Wei Gong, Lijuan Liu, Junko Sasaki, Takehiko Sasaki, Charles S Abrams, Yasunori Kanaho, Pietro De Camilli: Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain. J. Biol. Chem.. 2010.09; 285 (37): 28708-28714. ( PubMed , DOI )

  2. Junko Sasaki, Satoshi Kofuji, Reietsu Itoh, Toshihiko Momiyama, Kiyohiko Takayama, Haruka Murakami, Shinsuke Chida, Yuko Tsuya, Shunsuke Takasuga, Satoshi Eguchi, Ken Asanuma, Yasuo Horie, Kouichi Miura, Elizabeth Michele Davies, Christina Mitchell, Masakazu Yamazaki, Hirokazu Hirai, Tadaomi Takenawa, Akira Suzuki, Takehiko Sasaki: The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature. 2010.05; 465 (7297): 497-501. ( PubMed , DOI )

  3. Kazuya Tsujita, Toshiki Itoh, Akihiro Kondo, Masaaki Oyama, Hiroko Kozuka-Hata, Yasuhiro Irino, Junya Hasegawa, Tadaomi Takenawa: Proteome of acidic phospholipid-binding proteins: spatial and temporal regulation of Coronin 1A by phosphoinositides. J. Biol. Chem.. 2010.02; 285 (9): 6781-6789. ( PubMed , DOI )

  4. Honglu Zhang, Ju He, Tatiana G. Kutateladze, Takahiro Sakai, Takehiko Sasaki, Nicolas Markadieu, Christophe Erneux, Glenn D. Prestwich: 5-Stabilized Phosphatidylinositol 3,4,5-Trisphosphate Analogues Bind Grp1 PH, Inhibit Phosphoinositide Phosphatases, and Block Neutrophil Migration CHEMBIOCHEM. 2010.02; 11 (3): 388-395. ( PubMed , DOI )

  5. Takehiko Sasaki, Junko Sasaki, Shunsuke Takasuga, Satoshi Eguchi, Satoshi Kofuji: Physiology of phosphoinositide metabolism JOURNAL OF PHYSIOLOGICAL SCIENCES. 2010; 60 S68.

  6. Masahide Takeda, Wataru Ito, Masako Tanabe, Shigeharu Ueki, Junko Kihara, Hikari Kato, Tomomi Tanigai, Hiroyuki Kayaba, Takehiko Sasaki, Junichi Chihara: The Pathophysiological Roles of PI3Ks and Therapeutic Potential of Selective Inhibitors in Allergic Inflammation INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2010; 152 90-95. ( PubMed , DOI )

  1. Takehiko Sasaki, Shunsuke Takasuga, Junko Sasaki, Satoshi Kofuji, Satoshi Eguchi, Masakazu Yamazaki, Akira Suzuki: Mammalian phosphoinositide kinases and phosphatases. Prog. Lipid Res.. 2009.11; 48 (6): 307-343. ( PubMed , DOI )

  2. Toshiki Itoh, Junya Hasegawa, Kazuya Tsujita, Yasunori Kanaho, Tadaomi Takenawa: The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration. Sci Signal. 2009.09; 2 (87): ra52. ( PubMed , DOI )

  3. Naoki Kobayashi, Kohjiro Ueki, Takehiko Sasaki, Takashi Kadowaki: Crucial Role of Class IB PI3-Kinase, PI3K gamma, in Obesity-Induced Insulin Resistance DIABETES. 2009.06; 58 A352.

  4. Yumiko Anezaki, Shigetoshi Ohshima, Hajime Ishii, Nobukatsu Kinoshita, Takahiro Dohmen, Ei Kataoka, Wataru Sato, Masahiro Iizuka, Takashi Goto, Junko Sasaki, Takehiko Sasaki, Akira Suzuki, Hirohide Ohnishi, Yasuo Horie: Sex difference in the liver of hepatocyte-specific Pten-deficient mice: A model of nonalcoholic steatohepatitis. Hepatol. Res.. 2009.06; 39 (6): 609-618. ( PubMed , DOI )

  5. Akihiko Nishikimi, Hideo Fukuhara, Wenjuan Su, Tsunaki Hongu, Shunsuke Takasuga, Hisashi Mihara, Qinhong Cao, Fumiyuki Sanematsu, Motomu Kanai, Hiroshi Hasegawa, Yoshihiko Tanaka, Masakatsu Shibasaki, Yasunori Kanaho, Takehiko Sasaki, Michael A Frohman, Yoshinori Fukui: Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis. Science. 2009.04; 324 (5925): 384-387. ( PubMed , DOI )

  6. Hajime Ishii, Yasuo Horie, Shigetoshi Ohshima, Yumiko Anezaki, Nobukatsu Kinoshita, Takahiro Dohmen, Ei Kataoka, Wataru Sato, Takashi Goto, Junko Sasaki, Takehiko Sasaki, Sumio Watanabe, Akira Suzuki, Hirohide Ohnishi: Eicosapentaenoic acid ameliorates steatohepatitis and hepatocellular carcinoma in hepatocyte-specific Pten-deficient mice. J. Hepatol.. 2009.03; 50 (3): 562-571. ( PubMed , DOI )

  7. Chihiro Mogi, Masayuki Tobo, Hideaki Tomura, Naoya Murata, Xiao-Dong He, Koichi Sato, Takao Kimura, Tamotsu Ishizuka, Takehiko Sasaki, Takashi Sato, Yasuyuki Kihara, Satoshi Ishii, Akihiro Harada, Fumikazu Okajima: Involvement of Proton-Sensing TDAG8 in Extracellular Acidification-Induced Inhibition of Proinflammatory Cytokine Production in Peritoneal Macrophages JOURNAL OF IMMUNOLOGY. 2009.03; 182 (5): 3243-3251. ( PubMed , DOI )

  8. Yanfeng Wang, Xinsheng Chen, Lurong Lian, Tang Tang, Timothy J. Stalker, Takehiko Sasaki, Yasunori Kanaho, Lawrence F. Brass, John K. Choi, John H. Hartwig, Charles S. Abrams: Loss of PIP5KI beta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation (vol 105, pg 14064, 2008) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009.01; 106 (4): 1291. ( DOI )

  1. Manando Nakasaki, Kiyoko Yoshioka, Yasuhide Miyamoto, Takehiko Sasaki, Hideki Yoshikawa, Kazuyuki Itoh: IGF-I secreted by osteoblasts acts as a potent chemotactic factor for osteoblasts BONE. 2008.11; 43 (5): 869-879. ( PubMed , DOI )

  2. Yanfeng Wang, Xinsheng Chen, Lurong Lian, Tang Tang, Timothy J Stalker, Takehiko Sasaki, Yasunori Kanaho, Lawrence F Brass, John K Choi, John H Hartwig, Charles S Abrams: Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. Proc. Natl. Acad. Sci. U.S.A.. 2008.09; 105 (37): 14064-14069. ( PubMed , DOI )

  3. Tae Inoue-Narita, Koichi Hamada, Takehiko Sasaki, Sachiko Hatakeyama, Sachiko Fujita, Kohichi Kawahara, Masato Sasaki, Hiroyuki Kishimoto, Satoshi Eguchi, Itaru Kojima, Friedrich Beermann, Tetsunori Kimura, Masatake Osawa, Satoshi Itami, Tak Wah Mak, Toru Nakano, Motomu Manabe, Akira Suzuki: Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis. Cancer Res.. 2008.07; 68 (14): 5760-5768. ( PubMed , DOI )

  4. Hirohide Iwasaki, Yoshimichi Murata, Youngjun Kim, Md Israil Hossain, Carolyn A Worby, Jack E Dixon, Thomas McCormack, Takehiko Sasaki, Yasushi Okamura: A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc. Natl. Acad. Sci. U.S.A.. 2008.06; 105 (23): 7970-7975. ( PubMed , DOI )

  5. Shoko Kuroda, Miki Nishio, Takehiko Sasaki, Yasuo Horie, Koichi Kawahara, Masato Sasaki, Miyuki Natsui, Takashi Matozaki, Hiroyuki Tezuka, Toshiaki Ohteki, Irmgard Förster, Tak W Mak, Toru Nakano, Akira Suzuki: Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages. Eur J Immunol. 2008.05; 38 (5): 1331-1340. ( PubMed , DOI )

  6. Fabien Garçon, Daniel T Patton, Juliet L Emery, Emilio Hirsch, Robert Rottapel, Takehiko Sasaki, Klaus Okkenhaug: CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer. Blood. 2008.02; 111 (3): 1464-1471. ( PubMed , DOI )

  7. Yanfeng Wang, Rustem I Litvinov, Xinsheng Chen, Tami L Bach, Lurong Lian, Brian G Petrich, Susan J Monkley, Yasunori Kanaho, David R Critchley, Takehiko Sasaki, Morris J Birnbaum, John W Weisel, John Hartwig, Charles S Abrams: Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J. Clin. Invest.. 2008.02; 118 (2): 812-819. ( PubMed , DOI )

  8. H Kuwana, Y Terada, T Kobayashi, T Okado, J M Penninger, J Irie-Sasaki, T Sasaki, S Sasaki: The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity. Kidney Int.. 2008.02; 73 (4): 430-445. ( PubMed , DOI )

  9. Akira Suzuki, Toru Nakano, Tak Wah Mak, Takehiko Sasaki: Portrait of PTEN: messages from mutant mice. Cancer Sci.. 2008.02; 99 (2): 209-213. ( PubMed , DOI )

  10. Ken Tsukamoto, Kaoru Hazeki, Megumi Hoshi, Kiyomi Nigorikawa, Norimitsu Inoue, Takehiko Sasaki, Osamu Hazeki: Critical roles of the p110 beta subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells JOURNAL OF IMMUNOLOGY. 2008.02; 180 (4): 2054-2061. ( PubMed , DOI )

  1. Kristy A Horan, Ken-Ichi Watanabe, Anne M Kong, Charles G Bailey, John E J Rasko, Takehiko Sasaki, Christina A Mitchell: Regulation of FcgammaR-stimulated phagocytosis by the 72-kDa inositol polyphosphate 5-phosphatase: SHIP1, but not the 72-kDa 5-phosphatase, regulates complement receptor 3 mediated phagocytosis by differential recruitment of these 5-phosphatases to the phagocytic cup. Blood. 2007.12; 110 (13): 4480-4491. ( PubMed , DOI )

  2. Shigehisa Yanagi, Hiroyuki Kishimoto, Kohichi Kawahara, Takehiko Sasaki, Masato Sasaki, Miki Nishio, Nobuyuki Yajima, Koichi Hamada, Yasuo Horie, Hiroshi Kubo, Jeffrey A Whitsett, Tak Wah Mak, Toru Nakano, Masamitsu Nakazato, Akira Suzuki: Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J. Clin. Invest.. 2007.10; 117 (10): 2929-2940. ( PubMed , DOI )

  3. Takehiko Sasaki, Junko Sasaki, Takahiro Sakai, Shunsuke Takasuga, Akira Suzuki: The physiology of phosphoinositides. Biol. Pharm. Bull.. 2007.09; 30 (9): 1599-1604. ( PubMed )

  4. Yutaka Furutani, Hitomi Matsuno, Miwa Kawasaki, Takehiko Sasaki, Kensaku Mori, Yoshihiro Yoshihara: Interaction between telencephalin and ERM family proteins mediates dendritic filopodia formation JOURNAL OF NEUROSCIENCE. 2007.08; 27 (33): 8866-8876. ( PubMed , DOI )

  5. Hiroyuki Kishimoto, Toshiaki Ohteki, Nobuyuki Yajima, Koichi Kawahara, Miyuki Natsui, Satoru Kawarasaki, Koichi Hamada, Yasuo Horie, Yoshiaki Kubo, Seiji Arase, Masaru Taniguchi, Bart Vanhaesebroeck, Tak Wah Mak, Toru Nakano, Shigeo Koyasu, Takehiko Sasaki, Akira Suzuki: The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells. Blood. 2007.04; 109 (8): 3316-3324. ( PubMed , DOI )

  6. T Sasaki, J Sasaki, K Watanabe, A Suzuki: Non-invasive visualization of the lipid product of class I PI3K in transgenic mouse models. Biochem. Soc. Trans.. 2007.04; 35 (Pt 2): 215-218. ( PubMed , DOI )

  7. A. Suzuki, K. Hamada, T. Sasaki, T. W. Mak, T. Nakano: Role of PTEN/PI3K pathway ire endothelial cells BIOCHEMICAL SOCIETY TRANSACTIONS. 2007.04; 35 172-176.

  8. A. Suzuki, K. Hamada, T. Sasaki, T. W. Mak, T. Nakano: Role of PTEN/PI3K pathway ire endothelial cells BIOCHEMICAL SOCIETY TRANSACTIONS. 2007.04; 35 172-176.

  9. G John Ferguson, Laura Milne, Suhasini Kulkarni, Takehiko Sasaki, Simon Walker, Simon Andrews, Tom Crabbe, Peter Finan, Gareth Jones, Shaun Jackson, Montserrat Camps, Christian Rommel, Matthias Wymann, Emilio Hirsch, Phillip Hawkins, Len Stephens: PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis. Nat. Cell Biol.. 2007.01; 9 (1): 86-91. ( PubMed , DOI )

  10. Miki Nishio, Ken-ichi Watanabe, Junko Sasaki, Choji Taya, Shunsuke Takasuga, Ryota Iizuka, Tamas Balla, Masakazu Yamazaki, Hiroshi Watanabe, Reietsu Itoh, Shoko Kuroda, Yasuo Horie, Irmgard Förster, Tak W Mak, Hiromichi Yonekawa, Josef M Penninger, Yasunori Kanaho, Akira Suzuki, Takehiko Sasaki: Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat. Cell Biol.. 2007.01; 9 (1): 36-44. ( PubMed , DOI )

  11. Yutaka Furutani, Hitomi Matsuno, Miwa Kawasaki, Takehiko Sasaki, Kensaku Mori, Yoshihiro Yoshihara: Dendritic filopodia formation is mediated by the interaction between telencephalin and ERM proteins NEUROSCIENCE RESEARCH. 2007; 58 S130.

  1. Miwa Hebiguchi, Makoto Hirokawa, Yong-Mei Guo, Yoshinari Kawabata, Atsushi Komatsuda, Takehiko Sasaki, Yuichi Takakuwa, Ken-ichi Sawada: Enucleation of human erythroblasts is a process of asymmetric cytokinesis. BLOOD. 2006.11; 108 (11): 474A.

  2. Hirotaka Imai, Makoto Saito, Nozomu Kirai, Junya Hasegawa, Kumiko Konishi, Hiroyuki Hattori, Masuhiro Nishimura, Shinsaku Naito, Yasuhito Nakagawa: Identification of the positive regulatory and distinct core regions of promoters, and transcriptional regulation in three types of mouse phospholipid hydroperoxide glutathione peroxidase. J. Biochem.. 2006.10; 140 (4): 573-590. ( PubMed , DOI )

  3. Hiroshi Tsuruta, Hiroyuki Kishimoto, Takehiko Sasaki, Yasuo Horie, Miyuki Natsui, Yoshiko Shibata, Koichi Hamada, Nobuyuki Yajima, Koichi Kawahara, Masato Sasaki, Norihiko Tsuchiya, Katsuhiko Enomoto, Tak Wah Mak, Toru Nakano, Tomonori Habuchi, Akira Suzuki: Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients. Cancer Res.. 2006.09; 66 (17): 8389-8396. ( PubMed , DOI )

  4. Yuya Kunisaki, Akihiko Nishikimi, Yoshihiko Tanaka, Ryosuke Takii, Mayuko Noda, Ayumi Inayoshi, Ken-ichi Watanabe, Fumiyuki Sanematsu, Takehiko Sasazuki, Takehiko Sasaki, Yoshinori Fukui: DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis. J. Cell Biol.. 2006.08; 174 (5): 647-652. ( PubMed , DOI )

  5. Teruhiko Suzuki, Yoshiakira Kanai, Takahiko Hara, Junko Sasaki, Takehiko Sasaki, Michinori Kohara, Tomohiko Maehama, Choji Taya, Hiroshi Shitara, Hiromichi Yonekawa, Michael A Frohman, Takeaki Yokozeki, Yasunori Kanaho: Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol. Cell. Biol.. 2006.08; 26 (16): 6149-6156. ( PubMed , DOI )

  6. Min Zhao, Bing Song, Jin Pu, Teiji Wada, Brian Reid, Guangping Tai, Fei Wang, Aihua Guo, Petr Walczysko, Yu Gu, Takehiko Sasaki, Akira Suzuki, John V Forrester, Henry R Bourne, Peter N Devreotes, Colin D McCaig, Josef M Penninger: Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature. 2006.07; 442 (7101): 457-460. ( PubMed , DOI )

  7. Wataru Sato, Yasuo Horie, Ei Kataoka, Shigetoshi Ohshima, Takahiro Dohmen, Masahiro Iizuka, Junko Sasaki, Takehiko Sasaki, Koichi Hamada, Hiroyuki Kishimoto, Akira Suzuki, Sumio Watanabe: Hepatic gene expression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge. Hepatol. Res.. 2006.04; 34 (4): 256-265. ( PubMed , DOI )

  1. Koichi Hamada, Takehiko Sasaki, Pandelakis A Koni, Miyuki Natsui, Hiroyuki Kishimoto, Junko Sasaki, Nobuyuki Yajima, Yasuo Horie, Go Hasegawa, Makoto Naito, Jun-Ichi Miyazaki, Toshio Suda, Hiroshi Itoh, Kazuwa Nakao, Tak Wah Mak, Toru Nakano, Akira Suzuki: The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev.. 2005.09; 19 (17): 2054-2065. ( PubMed , DOI )

  2. Junko Sasaki, Takehiko Sasaki, Masakazu Yamazaki, Kunie Matsuoka, Choji Taya, Hiroshi Shitara, Shunsuke Takasuga, Miki Nishio, Katsunori Mizuno, Teiji Wada, Hideyuki Miyazaki, Hiroshi Watanabe, Ryota Iizuka, Shuichi Kubo, Shigeo Murata, Tomoki Chiba, Tomohiko Maehama, Koichi Hamada, Hiroyuki Kishimoto, Michael A Frohman, Keiji Tanaka, Josef M Penninger, Hiromichi Yonekawa, Akira Suzuki, Yasunori Kanaho: Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J. Exp. Med.. 2005.03; 201 (6): 859-870. ( PubMed , DOI )

  1. H Watanabe, T Yokozeki, M Yamazaki, H Miyazaki, T Sasaki, T Maehama, K Itoh, MA Frohman, Y Kanaho: Essential role for phospholipase D2 activation downstream of ERK MAP kinase in nerve growth factor-stimulated neurite outgrowth from PC12 cells JOURNAL OF BIOLOGICAL CHEMISTRY. 2004.09; 279 (36): 37870-37877. ( PubMed , DOI )

  2. K Reif, K Okkenhaug, T Sasaki, JM Penninger, B Vanhaesebroeck, JG Cyster: Cutting edge: Differential roles for phosphoinositide 3-kinases, p110 gamma and p110 delta, in lymphocyte chemotaxis and homing JOURNAL OF IMMUNOLOGY. 2004.08; 173 (4): 2236-2240. ( PubMed , DOI )

  3. Yasuo Horie, Akira Suzuki, Ei Kataoka, Takehiko Sasaki, Koichi Hamada, Junko Sasaki, Katsunori Mizuno, Go Hasegawa, Hiroyuki Kishimoto, Masahiro Iizuka, Makoto Naito, Katsuhiko Enomoto, Sumio Watanabe, Tak Wah Mak, Toru Nakano: Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J. Clin. Invest.. 2004.06; 113 (12): 1774-1783. ( PubMed , DOI )

  4. H Watanabe, M Yamazaki, H Miyazaki, C Arikawa, K Itoh, T Sasaki, T Maehama, MA Frohman, Y Kanaho: Phospholipase D2 functions as a downstream signaling molecule of MAP kinase pathway in L1-stimulated neurite outgrowth of cerebellar granule neurons JOURNAL OF NEUROCHEMISTRY. 2004.04; 89 (1): 142-151. ( PubMed , DOI )

  5. A Suzuki, T Sasaki, TW Mak, T Nakano: Functional analysis of the tumour suppressor gene PTEN in murine B cells and keratinocytes BIOCHEMICAL SOCIETY TRANSACTIONS. 2004.04; 32 362-365.

  6. Teiji Wada, Nicholas Joza, Hai-ying M Cheng, Takehiko Sasaki, Ivona Kozieradzki, Kurt Bachmaier, Toshiaki Katada, Martin Schreiber, Erwin F Wagner, Hiroshi Nishina, Josef M Penninger: MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Nat. Cell Biol.. 2004.03; 6 (3): 215-226. ( PubMed , DOI )

  1. S Giuriato, Pesesse, X, S Bodin, T Sasaki, C Viala, E Marion, J Penninger, S Schurmans, C Erneux, B Payrastre: SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels BIOCHEMICAL JOURNAL. 2003.11; 376 199-207. ( PubMed , DOI )

  2. Junko Irie-Sasaki, Takehiko Sasaki, Josef M Penninger: CD45 regulated signaling pathways. Curr Top Med Chem. 2003.11; 3 (7): 783-796. ( PubMed )

  3. Minna Woo, Razqallah Hakem, Caren Furlonger, Anne Hakem, Gordon S Duncan, Takehiko Sasaki, Denis Bouchard, Liwei Lu, Gillian E Wu, Christopher J Paige, Tak W Mak: Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity. Nat. Immunol.. 2003.10; 4 (10): 1016-1022. ( PubMed , DOI )

  4. Gavin Y Oudit, Michael A Crackower, Urs Eriksson, Renu Sarao, Ivona Kozieradzki, Takehiko Sasaki, Junko Irie-Sasaki, Dominica Gidrewicz, Vitalyi O Rybin, Teiji Wada, Susan F Steinberg, Peter H Backx, Josef M Penninger: Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation. 2003.10; 108 (17): 2147-2152. ( PubMed , DOI )

  5. AH Kim, T Sasaki, MV Chao: JNK-interacting protein 1 promotes Akt1 activation JOURNAL OF BIOLOGICAL CHEMISTRY. 2003.08; 278 (32): 29830-29836. ( PubMed , DOI )

  6. H Kishimoto, K Nakagawa, T Watanabe, D Kitagawa, H Momose, J Seo, G Nishitai, N Shimizu, S Ohata, S Tanemura, S Asaka, T Goto, H Fukushi, H Yoshida, A Suzuki, T Sasaki, T Wada, JM Penninger, H Nishina, T Katada: Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells JOURNAL OF BIOLOGICAL CHEMISTRY. 2003.05; 278 (19): 16595-16601. ( PubMed , DOI )

  7. A Suzuki, T Kaisho, M Ohishi, M Tsukio-Yamaguchi, T Tsubata, PA Koni, T Sasaki, TW Mak, T Nakano: Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination JOURNAL OF EXPERIMENTAL MEDICINE. 2003.03; 197 (5): 657-667. ( PubMed , DOI )

  8. M Nogami, M Yamazaki, H Watanabe, Y Okabayashi, Y Kido, M Kasuga, T Sasaki, T Maehama, Y Kanaho: Requirement of autophosphorylated tyrosine 992 of EGF receptor and its docking protein phospholipase C gamma l for membrane ruffle formation FEBS LETTERS. 2003.02; 536 (1-3): 71-76. ( PubMed , DOI )

  1. N Ito, T Yokomizo, T Sasaki, H Kurosu, J Penninger, Y Kanaho, T Katada, K Hanaoka, T Shimizu: Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B-4-induced enzyme release JOURNAL OF BIOLOGICAL CHEMISTRY. 2002.11; 277 (47): 44898-44904. ( PubMed , DOI )

  2. Michael A Crackower, Gavin Y Oudit, Ivona Kozieradzki, Renu Sarao, Hui Sun, Takehiko Sasaki, Emilio Hirsch, Akira Suzuki, Tetsuo Shioi, Junko Irie-Sasaki, Rajan Sah, Hai-Ying M Cheng, Vitalyi O Rybin, Giuseppe Lembo, Luigi Fratta, Antonio J Oliveira-dos-Santos, Jeffery L Benovic, C Ronald Kahn, Seigo Izumo, Susan F Steinberg, Matthias P Wymann, Peter H Backx, Josef M Penninger: Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell. 2002.09; 110 (6): 737-749. ( PubMed )

  3. Kenji Matsuno, Michio Ichimura, Takao Nakajima, Keiko Tahara, Shigeki Fujiwara, Hiroshi Kase, Junko Ushiki, Neill A Giese, Anjali Pandey, Robert M Scarborough, Nathalie A Lokker, Jin-Chen Yu, Junko Irie, Eiji Tsukuda, Shin-ichi Ide, Shoji Oda, Yuji Nomoto: Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 1. Synthesis, structure-activity relationship, and biological effects of a new class of quinazoline derivatives. J. Med. Chem.. 2002.07; 45 (14): 3057-3066. ( PubMed )

  4. M Yamazaki, H Miyazaki, H Watanabe, T Sasaki, T Maehama, MA Frohman, Y Kanaho: Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling JOURNAL OF BIOLOGICAL CHEMISTRY. 2002.05; 277 (19): 17226-17230. ( PubMed , DOI )

  5. Takehiko Sasaki, Akira Suzuki, Junko Sasaki, Josef M Penninger: Phosphoinositide 3-kinases in immunity: lessons from knockout mice. J. Biochem.. 2002.04; 131 (4): 495-501. ( PubMed )

  6. Connie Krawczyk, Antonio Oliveira-dos-Santos, Takehiko Sasaki, Emily Griffiths, Pamela S Ohashi, Scott Snapper, Fred Alt, Josef M Penninger: Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity. 2002.03; 16 (3): 331-343. ( PubMed )

  1. HK Yum, J Arcaroli, J Kupfner, R Shenkar, JM Penninger, T Sasaki, KY Yang, JS Park, E Abraham: Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury JOURNAL OF IMMUNOLOGY. 2001.12; 167 (11): 6601-6608. ( PubMed , DOI )

  2. R Hirose, H Okumura, A Yoshimatsu, J Irie, Y Onoda, Y Nomoto, H Takai, T Ohno, M Ichimura: KF31327, a new potent and selective inhibitor of cyclic nucleotide phosphodiesterase 5. Eur. J. Pharmacol.. 2001.11; 431 (1): 17-24. ( PubMed )

  3. T Sasaki, J Sasaki-Irie, J M Penninger: New insights into the transmembrane protein tyrosine phosphatase CD45. Int. J. Biochem. Cell Biol.. 2001.11; 33 (11): 1041-1046. ( PubMed )

  4. T Sasaki, T Wada, H Kishimoto, J Irie-Sasaki, G Matsumoto, T Goto, Z Yao, A Wakeham, T W Mak, A Suzuki, S K Cho, J C Zuniga-Pflucker, A J Oliveira-dos-Santos, T Katada, H Nishina, J M Penninger: The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells. J. Exp. Med.. 2001.09; 194 (6): 757-768. ( PubMed )

  5. Teiji Wada, Kentaro Nakagawa, Tomomi Watanabe, Gen Nishitai, Jungwon Seo, Hiroyuki Kishimoto, Daiju Kitagawa, Takehiko Sasaki, Josef M. Penninger, Hiroshi Nishina, Toshiaki Katada: Impaired synergistic activation of stress-activated protein kinase SAPK/ JNK in mouse embryonic stem cells lacking SEK1/MKK4: Different contribution of SEK2/MKK7 isoforms to the synergistic activation Journal of Biological Chemistry. 2001.08; 276 (33): 30892-30897. ( PubMed , DOI )

  6. J M Penninger, J Irie-Sasaki, T Sasaki, A J Oliveira-dos-Santos: CD45: new jobs for an old acquaintance. Nat. Immunol.. 2001.05; 2 (5): 389-396. ( PubMed , DOI )

  7. A Suzuki, M T Yamaguchi, T Ohteki, T Sasaki, T Kaisho, Y Kimura, R Yoshida, A Wakeham, T Higuchi, M Fukumoto, T Tsubata, P S Ohashi, S Koyasu, J M Penninger, T Nakano, T W Mak: T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity. 2001.05; 14 (5): 523-534. ( PubMed )

  8. N Joza, S A Susin, E Daugas, W L Stanford, S K Cho, C Y Li, T Sasaki, A J Elia, H Y Cheng, L Ravagnan, K F Ferri, N Zamzami, A Wakeham, R Hakem, H Yoshida, Y Y Kong, T W Mak, J C Zúñiga-Pflücker, G Kroemer, J M Penninger: Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature. 2001.03; 410 (6828): 549-554. ( PubMed , DOI )

  9. C Bony, S Roche, U Shuichi, T Sasaki, M A Crackower, J Penninger, H Mano, M Pucéat: A specific role of phosphatidylinositol 3-kinase gamma. A regulation of autonomic Ca(2)+ oscillations in cardiac cells. J. Cell Biol.. 2001.02; 152 (4): 717-728. ( PubMed )

  10. S Clément, U Krause, F Desmedt, J F Tanti, J Behrends, X Pesesse, T Sasaki, J Penninger, M Doherty, W Malaisse, J E Dumont, Y Le Marchand-Brustel, C Erneux, L Hue, S Schurmans: The lipid phosphatase SHIP2 controls insulin sensitivity. Nature. 2001.01; 409 (6816): 92-97. ( PubMed , DOI )

  11. J Irie-Sasaki, T Sasaki, W Matsumoto, A Opavsky, M Cheng, G Welstead, E Griffiths, C Krawczyk, C D Richardson, K Aitken, N Iscove, G Koretzky, P Johnson, P Liu, D M Rothstein, J M Penninger: CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature. 2001.01; 409 (6818): 349-354. ( PubMed , DOI )

  1. C Krawczyk, K Bachmaier, T Sasaki, R G Jones, S B Snapper, D Bouchard, I Kozieradzki, P S Ohashi, F W Alt, J M Penninger: Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity. 2000.10; 13 (4): 463-473. ( PubMed )

  2. AJ Oliveira-dos-Santos, G Matsumoto, BE Snow, DL Bai, FP Houston, IQ Whishaw, S Mariathasan, T Sasaki, A Wakeham, PS Ohashi, JC Roder, CA Barnes, DP Siderovski, JM Penninger: Regulation of T cell activation, anxiety, and male aggression by RGS2 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000.10; 97 (22): 12272-12277. ( PubMed , DOI )

  3. J E Fata, Y Y Kong, J Li, T Sasaki, J Irie-Sasaki, R A Moorehead, R Elliott, S Scully, E B Voura, D L Lacey, W J Boyle, R Khokha, J M Penninger: The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell. 2000.09; 103 (1): 41-50. ( PubMed )

  4. T Sasaki, J Irie-Sasaki, Y Horie, K Bachmaier, JE Fata, M Li, A Suzuki, D Bouchard, A Ho, M Redston, S Gallinger, R Khokha, TW Mak, PT Hawkins, L Stephens, SW Scherer, M Tsao, JM Penninger: Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)K gamma NATURE. 2000.08; 406 (6798): 897-902. ( PubMed , DOI )

  5. T Sasaki, J Irie-Sasaki, R G Jones, A J Oliveira-dos-Santos, W L Stanford, B Bolon, A Wakeham, A Itie, D Bouchard, I Kozieradzki, N Joza, T W Mak, P S Ohashi, A Suzuki, J M Penninger: Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science. 2000.02; 287 (5455): 1040-1046. ( PubMed )

  6. K Bachmaier, C Krawczyk, I Kozieradzki, Y Y Kong, T Sasaki, A Oliveira-dos-Santos, S Mariathasan, D Bouchard, A Wakeham, A Itie, J Le, P S Ohashi, I Sarosi, H Nishina, S Lipkowitz, J M Penninger: Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 2000.01; 403 (6766): 211-216. ( PubMed , DOI )

  1. H Watanabe, M Miura, T Sasaki: Differential effects of the insulin-like growth factor I receptor on radiosensitivity and spontaneous necrosis formation of human glioblastoma cells grown in multicellular spheroids EXPERIMENTAL CELL RESEARCH. 1999.07; 250 (1): 99-111.

  2. JM Penninger, KD Fischer, T Sasaki, Kozieradzki, I, J Le, K Tedford, K Bachmaier, PS Ohashi, MF Bachmann: The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation EUROPEAN JOURNAL OF IMMUNOLOGY. 1999.05; 29 (5): 1709-1718. ( PubMed , DOI )

  3. Q Liu, T Sasaki, I Kozieradzki, A Wakeham, A Itie, D J Dumont, J M Penninger: SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival. Genes Dev.. 1999.04; 13 (7): 786-791. ( PubMed )

  4. MA Lomaga, WC Yeh, Sarosi, I, GS Duncan, C Furlonger, A Ho, S Morony, C Capparelli, G Van, S Kaufman, A van der Heiden, A Itie, A Wakeham, W Khoo, T Sasaki, ZD Cao, JM Penninger, CJ Paige, DL Lacey, CR Dunstan, WJ Boyle, DV Goeddel, TW Mak: TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling GENES & DEVELOPMENT. 1999.04; 13 (8): 1015-1024. ( PubMed , DOI )

  5. A Hakem, T Sasaki, I Kozieradzki, J M Penninger: The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis. J. Exp. Med.. 1999.03; 189 (6): 957-968. ( PubMed )

  6. H Nishina, C Vaz, P Billia, M Nghiem, T Sasaki, JL De la Pompa, K Furlonger, C Paige, CC Hui, KD Fischer, H Kishimoto, T Iwatsubo, T Katada, Woodgett, JR, JM Penninger: Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4 DEVELOPMENT. 1999.02; 126 (3): 505-516. ( PubMed )

  1. T Sasaki, T Maehama, T Yamamoto, S Takasuga, S Hoshino, H Nishina, O Hazeki, T Katada: Activation of c-Jun N-terminal kinase (JNK) by lysophosphatidic acid in Swiss 3T3 fibroblasts JOURNAL OF BIOCHEMISTRY. 1998.11; 124 (5): 934-939. ( PubMed , DOI )

  2. V Stambolic, A Suzuki, J L de la Pompa, G M Brothers, C Mirtsos, T Sasaki, J Ruland, J M Penninger, D P Siderovski, T W Mak: Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell. 1998.10; 95 (1): 29-39. ( PubMed )

  3. H Nishina, L Radvanyi, K Raju, T Sasaki, Kozieradzki, I, JM Penninger: Impaired TCR-mediated apoptosis and Bcl-XL expression in T cells lacking the stress kinase activator SEK1/MKK4 JOURNAL OF IMMUNOLOGY. 1998.10; 161 (7): 3416-3420. ( PubMed )

  4. KD Fischer, YY Kong, H Nishina, K Tedford, LEM Marengere, Kozieradzki, I, T Sasaki, M Starr, G Chan, S Gardener, MP Nghiem, D Bouchard, M Barbacid, A Bernstein, JM Penninger: Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor CURRENT BIOLOGY. 1998.05; 8 (10): 554-562. ( PubMed , DOI )

  1. ZB Yao, K Diener, XS Wang, M Zukowski, G Matsumoto, GS Zhou, R Mo, T Sasaki, H Nishina, CC Hui, TH Tan, JP Woodgett, JM Penninger: Activation of stress-activated protein kinases c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase (MKK7) JOURNAL OF BIOLOGICAL CHEMISTRY. 1997.12; 272 (51): 32378-32383. ( PubMed , DOI )

  1. T Sasaki, K Hazeki, O Hazeki, M Ui, T Katada: Focal adhesion kinase (p125(FAK)) and paxillin are substrates for sphingomyelinase-induced tyrosine phosphorylation in Swiss 3T3 fibroblasts BIOCHEMICAL JOURNAL. 1996.05; 315 1035-1040. ( PubMed , DOI )

  1. T SASAKI, K HAZEKI, O HAZEKI, M UL, T KATADA: PERMISSIVE EFFECT OF CERAMIDE ON GROWTH FACTOR-INDUCED CELL-PROLIFERATION BIOCHEMICAL JOURNAL. 1995.11; 311 829-834. ( PubMed , DOI )

  1. Compartmentalization of phosphatidylinositol 4, 5-bisphosphate 2006.01; 54 (1): 45-50. ( PubMed )

  1. Involvement of phosphoinositide 3-kinases and phosphoinositide phosphatases in immune responses, glucose metabolism and tumorigenesis 2001.09; 46 (12): 1820-1829. ( PubMed )

  1. Phosphatidylinositol-3,5-bisphosphate: metabolism and physiological functions. Journal of biochemistry. 2013.07; ( PubMed , DOI )

  1. Takeda M, Ito W, Tanabe M, Ueki S, Kato H, Kihara J, Tanigai T, Chiba T, Yamaguchi K, Kayaba H, Imai Y, Okuyama K, Ohno I, Sasaki T, Chihara J: Allergic airway hyperresponsiveness, inflammation, and remodeling do not develop in phosphoinositide 3-kinase gamma-deficient mice. The Journal of allergy and clinical immunology. 2009.04; 123 805-812. ( PubMed , DOI )

  1. Hebiguchi M, Hirokawa M, Guo YM, Saito K, Wakui H, Komatsuda A, Fujishima N, Takahashi N, Takahashi T, Sasaki T, Nunomura W, Takakuwa Y, Sawada K: Dynamics of human erythroblast enucleation. International journal of hematology. 2008.12; 88 (5): 498-507. ( PubMed , DOI )

  2. [Phosphoinositides in membrane traffic]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 2008.12; ( PubMed )

  1. Sasaki T, Sasaki J, Sakai T, Takasuga S, Suzuki A: The physiology of phosphoinositides. Biological & pharmaceutical bulletin. 2007.09; 30 (9): 1599-1604. ( DOI )

  1. Nigorikawa K, Yoshikawa K, Sasaki T, Iida E, Tsukamoto M, Murakami H, Maehama T, Hazeki K, Hazeki O: A naphthoquinone derivative, shikonin, has insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and tyrosine phosphatases. Molecular pharmacology. 2006.09; 70 (3): 1143-1149. ( PubMed , DOI )

  1. Suzuki A, Itami S, Ohishi M, Hamada K, Inoue T, Komazawa N, Senoo H, Sasaki T, Takeda J, Manabe M, Mak TW, Nakano T: Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation. Cancer research. 2003.02; 63 674-681. ( PubMed )

  2. Kishimoto H, Hamada K, Saunders M, Backman S, Sasaki T, Nakano T, Mak TW, Suzuki A: Physiological functions of Pten in mouse tissues. Cell structure and function. 2003.02; 28 (1): 11-21. ( PubMed , DOI )

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