Department of Clinical Biostatistics

290  articles.  
* There may be some overlapped articles listed due to the difference of format.

  1. Mori N, Nanki T, Hirakawa A, Yamato M, Kaneko Y, Shiokawa R, Ozaki R, Kawabata N, Ohmagari N: Tocilizumab in combination with standard of care in patients with severe COVID-19 pneumonia: efficacy and safety from a phase 3 clinical trial in Japan. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2024.09; ( PubMed , DOI )

  2. Fujimaru T, Mori T, Sekine A, Chiga M, Mandai S, Kikuchi H, Mori Y, Hara Y, Fujiki T, Ando F, Susa K, Iimori S, Naito S, Hanazawa R, Hirakawa A, Mochizuki T, Suwabe T, Ubara Y, Uchida S, Sohara E: Importance of IFT140 in Patients with Polycystic Kidney Disease Without a Family History. Kidney international reports. 2024.09; 9 (9): 2685-2694. ( PubMed , DOI )

  3. Murofushi K, Katagiri H, Mitomo S, Hirohata K, Furuya H, Hanazawa R, Hirakawa A, Yagishita K, Kaneoka K: Exploring age-related changes in motor function: insights from the peak decline found in Koji Awareness screening test. Scientific reports. 2024.08; 14 (1): 18903. ( PubMed , DOI )

  4. Noritaka Suzuki, Yawara Eguchi, Takashi Hirai, Takuya Takahashi, Yohei Takahashi, Kota Watanabe, Tomohiro Banno, Kyohei Sakaki, Satoshi Maki, Yuuichi Takano, Yuki Taniguchi, Yasuchika Aoki, Takamitsu Konishi, Yutaka Hiraizumi, Masatsune Yamagata, Akihiro Hirakawa, Seiji Ohtori: Outcome of intradiscal condoliase injection therapy for patients with recurrent lumbar disc herniation. Asian Spine J. 2024.08; 18 (4): 550-559. ( PubMed , DOI )

  5. Sakyo Hirai, Ryoichi Hanazawa, Masataka Yoshimura, Keigo Shigeta, Yohei Sato, Naoki Taira, Yoshihisa Kawano, Jun Karakama, Yoshiki Obata, Mutsuya Hara, Kenji Yamada, Yosuke Ishii, Kana Sawada, Shogo Imae, Hikaru Wakabayashi, Hirotaka Sagawa, Kyohei Fujita, Shoko Fujii, Satoru Takahashi, Akihiro Hirakawa, Shigeru Nemoto, Kazutaka Sumita: Safety and Efficacy of Management for Intraprocedural Rupture During Endovascular Treatment for Intracranial Aneurysms. Neurosurgery. 2024.08; ( PubMed , DOI )

  6. Hajime Tanaka, Yuki Fukawa, Kouhei Yamamoto, Kousuke Tanimoto, Akira Takemoto, Takayasu Mori, Hisashi Hasumi, Mayumi Kinoshita, Takumi Kanazawa, Asuka Furukawa, Koichiro Kimura, Hiroyuki Sato, Akihiro Hirakawa, Shohei Fukuda, Yuma Waseda, Soichiro Yoshida, Steven C Campbell, Yasuhisa Fujii: Prognostic impact and genomic backgrounds of renal parenchymal infiltration or micronodular spread in non-metastatic clear cell renal cell carcinoma. Mod Pathol. 2024.08; 100590. ( PubMed , DOI )

  7. Harada T, Kobayashi T, Hirakawa A, Takayanagi T, Nogami M, Mochiyama T, Hirayama M, Foidart JM, Osuga Y: Efficacy and safety of estetrol (E4) 15 mg/drospirenone (DRSP) 3 mg combination in a cyclic regimen for the treatment of endometriosis-associated pain and objective gynecological findings: A multicenter, placebo-controlled, double-blind, randomized study. Fertility and sterility. 2024.07; ( PubMed , DOI )

  8. Ohara M, Hirata K, Matsubayashi T, Chen Q, Shimano K, Hanazawa R, Hirakawa A, Yokota T, Hattori T: Circular walking is useful for assessing the risk of falls in early progressive supranuclear palsy. Journal of neurology. 2024.07; ( PubMed , DOI )

  9. Nishikawa T, Kakunaga S, Tamura K, Ando M, Ozaki T, Kawai A, Ueda T, Kawasaki M, Tomatsuri S, Okamura N, Kamikura M, Hamada A, Yoshida A, Hirakawa A, Shibata T, Nakamura K, Yonemori K: Efficacy and safety of nivolumab monotherapy in patients with unresectable clear cell sarcoma and alveolar soft part sarcoma (OSCAR Trial/NCCH1510). Cancer. 2024.07; ( PubMed , DOI )

  10. Kobayashi M, Niimi M, Katsuda H, Akahoshi K, Kinowaki Y, Sasaki M, Hirakawa A, Tateishi U, Tanabe M, Okamoto R: Optimization of Endoscopic Ultrasound Characteristics in the Diagnosis of Malignant Intraductal Papillary Mucinous Neoplasm. Pancreas. 2024.07; 53 (6): e521-e527. ( PubMed , DOI )

  11. Ito S, Kinugasa Y, Yamauchi S, Sato H, Hirakawa A, Ishihara S, Shiomi A, Kanemitsu Y, Suto T, Takahashi H, Itabashi M, Shiozawa M, Hiyoshi M, Kobatake T, Komori K, Egi H, Ozawa H, Yamaguchi T, Inada R, Ito M, Hirano Y, Furutani A, Tanabe Y, Ueno H, Ohue M, Hida K, Kawai K, Sunami E, Ishida H, Uehara K, Watanabe J, Hotchi M, Ishibe A, Takii Y, Hiro J, Numata M, Takemasa I, Kato T, Kakeji Y, Hirata A, Ajioka Y: Long-term Outcome After Surgical Resection of Paraaortic Lymph Node Metastasis of Colorectal Cancer: A Multicenter Retrospective Study. Diseases of the colon and rectum. 2024.07; ( PubMed , DOI )

  12. Yamaoka H, Hirai S, Hanazawa R, Yoshimura M, Hayashi T, Kaneoka A, Yamada K, Yoshino Y, Ebiko Y, Yamamura T, Ishikawa M, Sagawa H, Aoyama J, Fujii S, Fujita K, Kawano Y, Hirakawa A, Sumita K: A thoracic CT imaging parameter predicting access difficulty in acute stroke thrombectomy. Clinical neurology and neurosurgery. 2024.07; 244 108453. ( PubMed , DOI )

  13. Takahashi Y, Kobori A, Hiroshima K, Sakamoto Y, Kimura M, Inaba O, Tanimoto K, Hanazawa R, Hirakawa A, Goya M, Sasano T: MAP-AF: A Multicenter, Single-Blind, Randomized Controlled Trial. Circulation. Arrhythmia and electrophysiology. 2024.07; 17 (8): e012829. ( PubMed , DOI )

  14. Sasaki M, Sato H, Uemura Y, Mikami A, Ichihara N, Fujitani S, Kondo M, Doi Y, Morino E, Tokita D, Ohmagari N, Sugiura W, Hirakawa A: How Much More Efficient Are Adaptive Platform Trials Than Multiple Stand-Alone Trials? A Comprehensive Simulation Study for Streamlining Drug Development During a Pandemic. Clinical pharmacology and therapeutics. 2024.06; 115 (6): 1372-1382. ( PubMed , DOI )

  15. Sakurai T, Sugimoto T, Akatsu H, Doi T, Fujiwara Y, Hirakawa A, Kinoshita F, Kuzuya M, Lee S, Matsumoto N, Matsuo K, Michikawa M, Nakamura A, Ogawa S, Otsuka R, Sato K, Shimada H, Suzuki H, Suzuki H, Takechi H, Takeda S, Uchida K, Umegaki H, Wakayama S, Arai H, J‐MINT study group: Japan-Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024.06; 20 (6): 3918-3930. ( PubMed , DOI )

  16. Mikamo H, Takahashi S, Yamagishi Y, Hirakawa A, Harada T, Nagashima H, Noguchi C, Masuko K, Maekawa H, Kashii T, Ohbayashi H, Hosokawa S, Maejima K, Yamato M, Manosuthi W, Paiboonpol S, Suganami H, Tanigawa R, Kawamura H, IVERMILCO Study Group: Efficacy and safety of ivermectin in patients with mild COVID-19 in Japan and Thailand. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2024.06; 30 (6): 536-543. ( PubMed , DOI )

  17. Yatabe Y, Hanaoka M, Hanazawa R, Hirakawa A, Mukai T, Kimura K, Yamanoi K, Kono J, Yokota M, Takahashi H, Kobayashi A, Kobayashi K, Ichikawa N, Yasui M, Nakane K, Yamamoto M, Takenaka A, Nakamura Y, Takemasa I, Yabusaki N, Akamoto S, Tatarano S, Murata K, Manabe T, Fujimura T, Kawamura M, Egi H, Yamaguchi S, Terai Y, Inoue S, Ito A, Kinugasa Y: Robotic versus open and laparoscopic pelvic exenterations for pelvic cancer: a multicenter propensity-matched analysis in Japan. Surgical endoscopy. 2024.06; 38 (8): 4390-4401. ( PubMed , DOI )

  18. Arai, S; Hanaoka, M; Yamauchi, S; Baba, H; Hanazawa, R; Sato, H; Hirakawa, A; Tokunaga, M; Kinugasa, Y: Modified oral antibiotics and mechanical bowel preparation (OAMBP) versus conventional OAMBP for sigmoid colon and rectal surgery: A multicenter randomized non-inferiority trial ANNALS OF GASTROENTEROLOGICAL SURGERY. 2024.06; ( DOI )

  19. Kato, M; Shiota, M; Kimura, T; Hanazawa, R; Hirakawa, A; Takamatsu, D; Tashiro, K; Matsui, Y; Hashine, K; Saito, R; Yokomizo, A; Yamamoto, Y; Narita, S; Hashimoto, K; Matsumoto, H; Akamatsu, S; Nishiyama, N; Eto, M; Kitamura, H; Tsuzuki, T: Validation study on the 2 mm diameter cutoff in lymph node-positive cases following radical prostatectomy in accordance with the AJCC/UICC TNM 8th edition: Real-world data analysis from a Japanese cohort INTERNATIONAL JOURNAL OF UROLOGY. 2024.06; 31 (6): 662-669. ( PubMed , DOI )

  20. Kawamura I, Miyazaki S, Inamura Y, Nitta J, Kobori A, Nakamura K, Murakami M, Nakamura T, Inaba O, Sekiguchi Y, Asano S, Sasaki Y, Mizuno S, Naito S, Hirakawa A, Sasano T: A randomized controlled trial of the size-adjustable cryoballoon vs conventional cryoballoon for paroxysmal atrial fibrillation: The CONTRAST-CRYO II trial rationale and design. Heart rhythm O2. 2024.05; 5 (5): 301-306. ( PubMed , DOI )

  21. Yamada, T; Minami, T; Yoshino, S; Emoto, K; Mabuchi, S; Hanazawa, R; Hirakawa, A; Hashimoto, M: Relationship Between Diaphragm Thickness, Thickening Fraction, Dome Excursion, and Respiratory Pressures in Healthy Subjects: An Ultrasound Study LUNG. 2024.04; 202 (2): 171-178. ( PubMed , DOI )

  22. Yukinori Kurokawa, Yuichiro Doki, Ryo Kitabayashi, Takaki Yoshikawa, Takashi Nomura, Kunihiro Tsuji, Masahiro Goto, Haruhiko Cho, Jun Hihara, Naoki Hiki, Souya Nunobe, Junki Mizusawa, Narikazu Boku, Masanori Terashima: Short-term outcomes of preoperative chemotherapy with docetaxel, oxaliplatin, and S-1 for gastric cancer with extensive lymph node metastasis (JCOG1704). Gastric Cancer. 2024.03; 27 (2): 366-374. ( PubMed , DOI )

  23. Kobayashi D, Kodera Y, Fukushima R, Morita M, Fushida S, Yamashita N, Yoshikawa K, Ueda S, Yabusaki H, Kusumoto T, Arigami T, Hidemura A, Omori T, Yamaguchi H, Hirono Y, Tsuji Y, Moon JH, Tomita T, Imamura H, Nakanishi K, Shimizu D, Hirakawa A, Ishigami H, Kitayama J.: Phase II Study of Intraperitoneal Administration of Paclitaxel Combined with S-1 and Cisplatin for Gastric Cancer with Peritoneal Metastasis. Ann Surg Oncol. 2024.02; 31 (2): 735-743. ( PubMed , DOI )

  24. Ikenaga N, Hashimoto T, Mizusawa J, Kitabayashi R, Sano Y, Fukuda H, Nakata K, Shibuya K, Kitahata Y, Takada M, Kamei K, Kurahara H, Ban D, Kobayashi S, Nagano H, Imamura H, Unno M, Takahashi A, Yagi S, Wada H, Shirakawa H, Yamamoto N, Hirono S, Gotohda N, Hatano E, Nakamura M, Ueno M, on behalf of the Hepatobiliary and Pancreatic Oncology Group in Japan Clinical Oncology Group: A multi-institutional randomized phase III study comparing minimally invasive distal pancreatectomy versus open distal pancreatectomy for pancreatic cancer; Japan Clinical Oncology Group study JCOG2202 (LAPAN study). BMC cancer. 2024.02; 24 (1): 231. ( PubMed , DOI )

  25. Fujita K, Sato Y, Hanazawa R, Sagawa H, Ishikawa M, Fujii S, Aoyama J, Hirai S, Yoshimura M, Yoshino Y, Kawano Y, Shigeta K, Taira N, Karakama J, Ishiwada T, Yamashina M, Hirakawa A, Sumita K: Impact of cancer history on long-term outcome after elective neuro-endovascular treatment in patients aged 80 years or older: A retrospective multicenter observational study. Geriatrics & gerontology international. 2024.02; 24 (2): 211-217. ( PubMed , DOI )

  26. Hirai S, Fujita K, Fujii S, Takahashi S, Shigeta K, Karakama J, Enomoto Y, Sato Y, Yoshimura M, Hirota S, Mizoue T, Yoshino Y, Kawano Y, Yamamura T, Kohyama S, Hirohata M, Yoshimura S, Ishii Y, Yamauchi T, Taira N, Obata Y, Sakamoto M, Inoue M, Yamashina M, Tokunaga S, Higashi T, Sawada K, Mochida H, Ido K, Takeuchi M, Takigawa T, Takagi Y, Morimoto M, Nanto M, Miki K, Misaki K, Arimura K, Hanaoka Y, Hara M, Hara S, Yokoyama K, Ooyama J, Hanazawa R, Sato H, Hirakawa A, Ishiguro M, Nemoto S, Sumita K: Study protocol of the ASTOP trial: A multicenter, randomized, double-blind, placebo-controlled trial of presurgical aspirin administration for the prevention of thromboembolic complications of coil embolization for ruptured aneurysms. PloS one. 2024; 19 (9): e0310906. ( PubMed , DOI )

  1. Niizuma K, Osawa S, Endo H, Izumi S, Ataka K, Hirakawa A, Iwano M, Tominaga T: Randomized placebo-controlled trial of CL2020, an allogenic muse cell-based product, in subacute ischemic stroke. J Cereb Blood Flow Metab. 2023.12; 43 (12): 2029-2039. ( PubMed , DOI )

  2. Okuma HS, Watanabe K, Tsuchihashi K, Machida R, Sadachi R, Hirakawa A, Ariyama H, Kanai M, Kamikura M, Anjo K, Hiramitsu A, Sekine S, Okita N, Mano H, Nishikawa H, Nakamura K, Yonemori K: Phase II Trial of Nivolumab in Metastatic Rare Cancer with dMMR or MSI-H and Relation with Immune Phenotypic Analysis (the ROCK Trial). Clin Cancer Res. 2023.12; 29 (24): 5079-5086. ( PubMed , DOI )

  3. Ikenouchi, T; Miyazaki, S; Nitta, J; Sekiguchi, Y; Kobori, A; Nakamura, K; Inamura, Y; Murakami, M; Sagawa, Y; Sasaki, Y; Inaba, O; Yamauchi, Y; Naito, S; Hirakawa, A; Sasano, T: Characteristics of two different cryoballoon systems for treatment of paroxysmal atrial fibrillation: study protocol for a multicenter randomized controlled trial (CONTRAST-CRYO Trial) JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY. 2023.12; 67 (1): 5-12. ( PubMed , DOI )

  4. Yamada T, Minami T, Yoshino S, Emoto K, Mabuchi S, Hanazawa R, Hirakawa A, Hashimoto M: Diaphragm Ultrasonography: Reference Values and Influencing Factors for Thickness, Thickening Fraction, and Excursion in the Seated Position. Lung. 2023.11; 202 (1): 83-90. ( PubMed , DOI )

  5. Mitsui Y, Bando YK, Hirakawa A, Furusawa K, Morimoto R, Taguchi E, Kimura A, Kamiya H, Nishikimi N, Komori K, Nishigami K, Murohara T: Role of Common Antihypertensives in the Growth of Abdominal Aortic Aneurysm at the Presurgical Stage. Circ Rep. 2023.11; 5 (11): 405-414. ( PubMed , DOI )

  6. Sadachi R, Sato H, Fujiwara T, Hirakawa A: Enhancement of Bayesian optimal interval design by accounting for overdose and underdose errors trade-offs. J Biopharm Stat. 2023.11; 1-20. ( PubMed , DOI )

  7. Komatsuzaki K, Kageshima H, Sekino Y, Suzuki Y, Ugajin T, Tamaoka M, Hanazawa R, Hirakawa A, Miyazaki Y: Local nasal immunotherapy with birch pollen-galactomannan conjugate-containing ointment in mice and humans. Allergology international : official journal of the Japanese Society of Allergology. 2023.11; ( PubMed , DOI )

  8. Shuheng Wen, Kana Unuma, Ryoichi Hanazawa, Shutaro Nagano, Ryo Watanabe, Akihiro Hirakawa, Koichi Uemura: Alcohol and toxicological factors influencing fatal falls from height in the Greater Tokyo Area: a retrospective study. Int J Legal Med. 2023.11; ( PubMed , DOI )

  9. Masaaki Mori, Kanako Yoshizaki, Shinichi Watabe, Mika Ishige, Akinari Hinoki, Takuya Kondo, Tomoaki Taguchi, Hisaya Hasegawa, Tomoko Hatata, Naoyuki Tanuma, Kosuke Kirino, Akihiro Hirakawa, Takuya Naruto, Minoru Imai, Ryuji Koike, Kenichiro Hosoi, Satoshi Kusuda: Safety, efficacy and pharmacokinetics of palivizumab in off-label neonates, infants, and young children at risk for serious respiratory syncytial virus infection: a multicenter phase II clinical trial. Lancet Reg Health West Pac. 2023.10; 39 100847. ( PubMed , DOI )

  10. Kinoshita F, Yoshida K, Fujitani M, Imai Y, Kobayashi Y, Ito T, Okumura Y, Sato H, Mikami T, Jung S, Hirakawa A, Nakatochi M: Lifestyle parameters of Japanese agricultural and non-agricultural workers aged 60 years or older and less than 60 years: A cross-sectional observational study. PLoS One. 2023.10; 18 (10): e0290662. ( PubMed , DOI )

  11. Shigeta T, Miyazaki S, Inaba O, Inamura Y, Nitta J, Sekiguchi Y, Takahashi A, Hachiya H, Nagata Y, Yamauchi Y, Hayashi T, Iwai S, Mizukami A, Ono Y, Handa K, Suzuki M, Suzuki A, Nakajima J, Hirao K, Okada H, Negishi M, Ikenouchi T, Yamamoto T, Goto K, Nishimura T, Tao S, Takigawa M, Hirakawa A, Goya M, Sasano T: Adjunctive posterior wall isolation for the treatment of persistent and longstanding persistent atrial fibrillation (CORNERSTONE AF) trial: Design and rationale. Clinical cardiology. 2023.10; 47 (1): e24164. ( PubMed , DOI )

  12. Mizusawa J, Sato H, Rubinstein LV, Fujiwara T, Yonemori K*, Hirakawa A*: Racial differences in longitudinal toxicities of anticancer agents in early phase cancer clinical trials. Cancer Med. 2023.09; 12 (17): 18098-18109. ( PubMed , DOI )

  13. Sakyo Hirai, Akihiro Hirakawa, Kyohei Fujita, Tadahiro Ishiwada, Masanao Sasaki, Masataka Yoshimura, Keigo Shigeta, Yohei Sato, Kenji Yamada, Mariko Ishikawa, Hirotaka Sagawa, Jiro Aoyama, Shoko Fujii, Yosuke Ishii, Kana Sawada, Yoshiki Obata, Jun Karakama, Mutsuya Hara, Yoshihisa Kawano, Shigeru Nemoto, Kazutaka Sumita: Imaging predictors of clinical outcomes after endovascular treatment in MRI-selected patients with acute basilar artery occlusion. Clinical Neurology and Neurosurgery . 2023.08; 231 107824. ( PubMed , DOI )

  14. Koyama T, Shimizu T, Kojima Y, Sudo K, Okuma HS, Shimoi T, Ichikawa H, Kohsaka S, Sadachi R, Hirakawa A, Yoshida A, Ando RM, Ueno T, Yanagaki M, Matsui N, Nakamura K, Yamamoto N, Yonemori K: Clinical Activity and Exploratory Resistance Mechanism of Milademetan, an MDM2 Inhibitor, in Intimal Sarcoma with MDM2 Amplification: An Open-Label Phase Ib/II Study. Cancer discovery. 2023.08; 13 (8): 1814-1825. ( PubMed , DOI )

  15. Yokoi A, Ukai M, Yasui T, Inokuma Y, Kim HD, Matsuzaki J, Yoshida K, Kitagawa M, Chattrairat K, Iida M, Shimada T, Manabe Y, Chang IY, Asano-I E, Koya Y, Nawa A, Nakamura K, Kiyono T, Kato T, Hirakawa A, Yoshioka Y, Ochiya T, Hasegawa T, Baba Y, Yamamoto Y, Kajiyama H: Identifying high-grade serous ovarian carcinoma-specific extracellular vesicles by polyketone-coated nanowires. Sci Adv. 2023.07; 9 (27): eade6958. ( PubMed , DOI )

  16. Yamaguchi Y, Tanaka H, Kimura K, Fukuda S, Fukushima H, Waseda Y, Yoshida S, Yokoyama M, Hirakawa A, Tateishi U, Campbell SC, Fujii Y: Prognostic impact of the radiological infiltrative feature of primary renal tumor in metastatic renal cell carcinoma. International journal of urology : official journal of the Japanese Urological Association. 2023.06; ( PubMed , DOI )

  17. Yuji Akiyama, Hitoshi Katai, Ryo Kitabayashi, Souya Nunobe, Keisuke Koeda, Masahiro Yura, Yuya Sato, Takaki Yoshikawa, Masanori Terashima: Frequency of lymph node metastasis according to tumor location in clinical T1 early gastric cancer: supplementary analysis of the Japan Clinical Oncology Group study (JCOG0912). Journal of Gastroenterology. 2023.06; 58 (6): 519-526. ( PubMed , DOI )

  18. Hosoya T, Oba S, Komiya Y, Kawata D, Kamiya M, Iwai H, Miyamoto S, Kataoka M, Tobiume M, Kanno T, Ainai A, Sato H, Hirakawa A, Mitsui Y, Satoh T, Wakabayashi K, Yamada T, Otomo Y, Miyazaki Y, Hasegawa H, Suzuki T, Yasuda S: Apple-shaped obesity: A risky soil for cytokine-accelerated severity in COVID-19. Proceedings of the National Academy of Sciences of the United States of America. 2023.05; 120 (22): e2300155120. ( PubMed , DOI )

  19. Nakamura R, Tohnai G, Nakatochi M, Atsuta N, Watanabe H, Ito D, Katsuno M, Hirakawa A, Izumi Y, Morita M, Hirayama T, Kano O, Kanai K, Hattori N, Taniguchi A, Suzuki N, Aoki M, Iwata I, Yabe I, Shibuya K, Kuwabara S, Oda M, Hashimoto R, Aiba I, Ishihara T, Onodera O, Yamashita T, Abe K, Mizoguchi K, Shimizu T, Ikeda Y, Yokota T, Hasegawa K, Tanaka F, Nakashima K, Kaji R, Niwa JI, Doyu M, Terao C, Ikegawa S, Fujimori K, Nakamura S, Ozawa F, Morimoto S, Onodera K, Ito T, Okada Y, Okano H, Sobue G, Japanese Consortium for Amyotrophic Lateral Sclerosis research (JaCALS) study group: Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients. Journal of neurology, neurosurgery, and psychiatry. 2023.05; 94 (10): 816-824. ( PubMed , DOI )

  20. Unuma K, Sato H, Wen S, Makino Y, Hirakawa A, Uemura K: The proportion of false-positives in positive Seratec® prostate-specific antigen SemiQuant test results in postmortem screening for seminal fluid. Legal medicine (Tokyo, Japan). 2023.05; 62 102243. ( PubMed , DOI )

  21. Omori H, Kawase Y, Mizukami T, Tanigaki T, Hirata T, Okubo M, Kamiya H, Hirakawa A, Kawasaki M, Kondo T, Suzuki T, Matsuo H: Diagnostic Accuracy of Artificial Intelligence-Based Angiography-Derived Fractional Flow Reserve Using Pressure Wire-Based Fractional Flow Reserve as a Reference. Circulation journal : official journal of the Japanese Circulation Society. 2023.05; 87 (6): 783-790. ( PubMed , DOI )

  22. Nishikawa T, Hasegawa K, Matsumoto K, Mori M, Hirashima Y, Takehara K, Ariyoshi K, Kato T, Yagishita S, Hamada A, Kawasaki M, Kawashima S, Tomatsuri S, Nagasaka Y, Yoshida H, Machida R, Hirakawa A, Nakamura K, Yonemori K: Trastuzumab Deruxtecan for Human Epidermal Growth Factor Receptor 2-Expressing Advanced or Recurrent Uterine Carcinosarcoma (NCCH1615): The STATICE Trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2023.05; 41 (15): 2789-2799. ( PubMed , DOI )

  23. Ohara M, Hirata K, Hallett M, Matsubayashi T, Chen Q, Kina S, Shimano K, Hirakawa A, Yokota T, Hattori T: Long-term levodopa ameliorates sequence effect in simple, but not complex walking in early Parkinson's disease patients. Parkinsonism & related disorders. 2023.03; 108 105322. ( PubMed , DOI )

  24. Asano J, Sato H, Hirakawa A: Practical basket design for binary outcomes with control of family-wise error rate. BMC medical research methodology. 2023.02; 23 (1): 52. ( PubMed , DOI )

  25. Hattori T, Ohara M, Yuasa T, Azuma R, Chen Q, Hanazawa R, Hirakawa A, Orimo S, Yokota T: Correlation of callosal angle at the splenium with gait and cognition in normal pressure hydrocephalus. Journal of neurosurgery. 2023.01; 139 (2): 1-11. ( PubMed , DOI )

  26. Kyohei Sakaki, Toshitaka Yoshii, Yoshiyasu Arai, Ichiro Torigoe, Masaki Tomori, Hiroaki Onuma, Takahisa Ogawa, Akihiro Hirakawa, Kenichiro Sakai, Atsushi Okawa: Effectiveness of Lumbosacral Orthosis After Discectomy for Lumbar Disk Herniation: A Prospective Comparative Study. Spine (Phila Pa 1976). 2023.01; 48 (1): 15-20. ( PubMed , DOI )

  27. Hanazawa R, Sato H, Sasaki M, Suzuki K, Hirakawa A: Study designs and statistical analyses in randomized controlled trials of non-pharmacological preventive and therapeutic interventions for dementia continuum : A statistical review Dementia Japan. 2023.01; 37 (1): 96-132.

  28. Oba S, Hosoya T, Kaneshige R, Kawata D, Yamaguchi T, Mitsumura T, Shimada S, Shibata S, Tateishi T, Koike R, Tohda S, Hirakawa A, Yoko N, Otomo Y, Nojima J, Miyazaki Y, Yasuda S: Thrombosis and antiphospholipid antibodies in Japanese COVID-19: based on propensity score matching. Frontiers in immunology. 2023; 14 1227547. ( PubMed , DOI )

  1. Maruyama F, Masuda T, Nosaka N, Wakabayashi K: Case of laryngeal venous malformations requiring repeated advanced airway management in the perioperative course. Clinical case reports. 2022.12; 10 (12): e6687. ( PubMed , DOI )

  2. Shitara K, Kawazoe A, Hirakawa A, Nakanishi Y, Furuki S, Fukuda M, Ueno Y, Raizer J, Arozullah A: Phase 1 trial of zolbetuximab in Japanese patients with CLDN18.2+ gastric or gastroesophageal junction adenocarcinoma. Cancer science. 2022.12; 114 (4): 1606-1615. ( PubMed , DOI )

  3. Takenaka K, Kitazume Y, Kawamoto A, Fujii T, Udagawa Y, Wanatabe R, Shimizu H, Hibiya S, Nagahori M, Ohtsuka K, Sato H, Hirakawa A, Watanabe M, Okamoto R: Serum Leucine-Rich α2 Glycoprotein: A Novel Biomarker for Transmural Inflammation in Crohn's Disease. The American journal of gastroenterology. 2022.12; 118 (6): 1028-1035. ( PubMed , DOI )

  4. Yamada S, Hashizume A, Hijikata Y, Inagaki T, Ito D, Kishimoto Y, Kinoshita F, Hirakawa A, Shimizu S, Nakamura T, Katsuno M: Mexiletine in spinal and bulbar muscular atrophy: a randomized controlled trial. Annals of clinical and translational neurology. 2022.11; 9 (11): 1702-1714. ( PubMed , DOI )

  5. Takahashi Y, Yamamoto T, Oyama J, Sugihara G, Shirai Y, Tao S, Takigawa M, Sato H, Sasaki M, Hirakawa A, Takahashi H, Goya M, Sasano T: Increase in Cerebral Blood Flow After Catheter Ablation of Atrial Fibrillation. JACC. Clinical electrophysiology. 2022.11; 8 (11): 1369-1377. ( PubMed , DOI )

  6. Kawahara T, Iwamoto T, Takashima I, Hanazawa R, Uemura K, Uemura Y, Mukai H, Kikawa Y, Taira N: Association of change in health-related quality of life and treatment discontinuation in metastatic breast cancer: a post hoc, exploratory analysis of two randomized clinical trials Support Care Cancer. 2022.10; 30 (10): 8367-8375. ( PubMed , DOI )

  7. Inagaki T, Hashizume A, Hijikata Y, Yamada S, Ito D, Kishimoto Y, Torii R, Sato H, Hirakawa A, Katsuno M: Development of a functional composite for the evaluation of spinal and bulbar muscular atrophy. Scientific reports. 2022.10; 12 (1): 17443. ( PubMed , DOI )

  8. Oda G, Nakagawa T, Mori H, Onishi I, Fujioka T, Mori M, Kubota K, Hanazawa R, Hirakawa A, Ishikawa T, Okamoto K, Uetake H: Factors predicting upstaging from clinical N0 to pN2a/N3a in breast cancer patients. World Journal of Clinical Oncology. 2022.09; 13 (9): 748-757. ( PubMed , DOI )

  9. Nakayama K, Shachar S, Finn EH, Sato H, Hirakawa A, Misteli T: Large-scale mapping of positional changes of hypoxia-responsive genes upon activation. Molecular biology of the cell. 2022.07; 33 (8): ar72. ( PubMed , DOI )

  10. Hirakawa A, Sato H, Hanazawa R, Suzuki K, Japanese Alzheimer's Disease Neuroimaging Initiative.: Estimating the longitudinal trajectory of cognitive function measurement using short-term data with different disease stages: Application in Alzheimer's disease. Statistics in medicine. 2022.06; 41 (21): 4200-4214. ( PubMed , DOI )

  11. Hiroyuki Inose, Tsuyoshi Kato, Masanao Sasaki, Yu Matsukura, Takashi Hirai, Toshitaka Yoshii, Shigenori Kawabata, Akihiro Hirakawa, Atsushi Okawa: Comparison of decompression, decompression plus fusion, and decompression plus stabilization: a long-term follow-up of a prospective, randomized study. Spine J. 2022.05; 22 (5): 747-755. ( PubMed , DOI )

  12. Kotani T, Imai K, Ushida T, Moriyama Y, Nakano-Kobayashi T, Osuka S, Tsuda H, Sumigama S, Yamamoto E, Kinoshita F, Hirakawa A, Iwase A, Kikkawa F, Kajiyama H: Pregnancy Outcomes in Women with Thyroid Diseases. JMA journal. 2022.04; 5 (2): 216-223. ( PubMed , DOI )

  13. Matsuyama N, Shimizu S, Ueda K, Suzuki T, Suzuki S, Miura R, Katayama A, Ando M, Mizuno M, Hirakawa A, Hayakawa M, Sato Y: Safety and tolerability of a multilineage-differentiating stress-enduring cell-based product in neonatal hypoxic-ischaemic encephalopathy with therapeutic hypothermia (SHIELD trial): a clinical trial protocol open-label, non-randomised, dose-escalation trial. BMJ OPEN. 2022.04; 12 (4): ( DOI )

  14. Takino K, Kameshima M, Asai C, Kawamura I, Tomita S, Sato H, Hirakawa A, Yamada S: Neuromuscular electrical stimulation after cardiovascular surgery mitigates muscle weakness in older individuals with diabetes. Annals of physical and rehabilitation medicine. 2022.03; 66 (2): 101659. ( PubMed , DOI )

  15. Hirakawa A, Sato H, Igeta M, Fujikawa K, Daimon T, Teramukai S: Regulatory issues and the potential use of Bayesian approaches for early drug approval systems in Japan. Pharmaceutical statistics. 2022.01; 21 (3): 691-695. ( PubMed , DOI )

  1. Yoshiko Ishisaka, Nobuyuki Nosaka, Yuka Mishima, Takahiro Masuda, Michio Nagashima, Yosuke Tanaka, Kouhei Yamamoto, Masayuki Yoshida, Hidenobu Shigemitsu: COVID-19 case of ventilator-induced lung injury on extracorporeal membrane oxygenation: Physicians' clinical struggle and ethical conflict in a novel pandemic. Clin Case Rep. 2021.12; 9 (12): e05223. ( PubMed , DOI )

  2. Nobuyuki Nosaka, Takahiro Masuda: Sedation and Ventilator Liberation Protocol vs Usual Care and Duration of Invasive Ventilation in Pediatric Intensive Care Units. JAMA. 2021.12; 326 (22): 2328-2329. ( PubMed , DOI )

  3. Oba S, Hosoya T, Amamiya M, Mitsumura T, Kawata D, Sasaki H, Kamiya M, Yamamoto A, Ando T, Shimada S, Shirai T, Okamoto T, Tateishi T, Endo A, Aiboshi J, Nosaka N, Yamanouchi H, Ugawa T, Nagaoka E, Oi K, Tao S, Maejima Y, Tanaka Y, Tanimoto K, Takeuchi H, Tohda S, Hirakawa A, Sasano T, Arai H, Otomo Y, Miyazaki Y, Yasuda S: Arterial and Venous Thrombosis Complicated in COVID-19: A Retrospective Single Center Analysis in Japan Frontiers in Cardiovascular Medicine. 2021.11;

  4. Takenaka K, Fujii T, Kawamoto A, Suzuki K, Shimizu H, Maeyashiki C, Yamaji O, Motobayashi M, Igarashi A, Hanazawa R, Hibiya S, Nagahori M, Saito E, Okamoto R, Ohtsuka K, Watanabe M: Deep neural network for video colonoscopy of ulcerative colitis: a cross-sectional study Lancet Gastroenterology & Hepatology. 2021.11; 7 (3): 230-237. ( PubMed , DOI )

  5. Noda-Narita S, Kawachi A, Okuyama A, Sadachi R, Hirakawa A, Goto Y, Fujiwara Y, Higashi T, Yonemori K: First-line treatment for lung cancer among Japanese older patients: a real-world analysis of hospital-based cancer registry data PLOS ONE. 2021.09; 16 (9): ( DOI )

  6. Ezaki A, Hirakawa A, Hanaoka H, Uyama Y: Factors Influencing Classifications of Safety Specifications in a Risk Management Plan for Antineoplastic Agents Approved in Japan: A Review and Descriptive Analysis. Therapeutic innovation & regulatory science. 2021.09; 55 (5): 1075-1081. ( PubMed , DOI )

  7. Masuda T, Nosaka N, Nagashima M: Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients. JAMA. 2021.08; 326 (6): 568-569. ( PubMed , DOI )

  8. Masuda T, Uchimido R, Nosaka N, Akiyama H, Kamisato A, Yoshida M: Concerns in Methodology for Self-Administered Questionnaire: Needs for Involvement of Social Scientists. Chest. 2021.07; 160 (1): e92-e93. ( PubMed , DOI )

  9. Takahiro Masuda, Nobuyuki Nosaka, Ryo Uchimido, Michio Nagashima: Use of stylet and airway management procedure in critically ill patients. Intensive Care Med. 2021.07; 47 (12): 1497-1498. ( PubMed , DOI )

  10. Takahashi Y, Nitta J, Kobori A, Sakamoto Y, Nagata Y, Tanimoto K, Matsuo S, Yamane T, Morita N, Satomi K, Inaba O, Murata K, Sasaki Y, Yoshimoto D, Kaneko M, Tanimoto Y, Isogai R, Yamashita S, Sato H, Hanazawa R, Hirakawa A, Goya M, Sasano T.: Alcohol Consumption Reduction and Clinical Outcomes of Catheter Ablation for Atrial Fibrillation Circulation:Arrhythmia and electrophysiology. 2021.06; 14 (6):

  11. Omori H, Hara M, Sobue Y, Kawase Y, Mizukami T, Tanigaki T, Hirata T, Ota H, Okubo M, Hirakawa A, Suzuki T, Kondo T, Leipsic J, NØrgaard B L, Matsuo H.: Determination of the Optimal Measurement Point for Fractional Flow Reserve Derived From CTA Using Pressure Wire Assessment as Reference American Journal of Roentgenology. 2021.06; 216 (6): 1492-1499.

  12. Ezaki A, Hirakawa A, Hanaoka H, Uyama Y. : Factors Influencing Classifications of Safety Specifications in a Risk Management Plan for Antineoplastic Agents Approved in Japan: A Review and Descriptive Analysis Therapeutic innovation & regulatory science. 2021.06;

  13. Sugimoto T, Sakurai T, Akatsu H, Doi T, Fujiwara Y, Hirakara A, Kinoshita F, Kuzuya M, Lee S, Matsuo K, Michikawa M, Ogawa S, Otsuka R, Sato K, Shimada H, Suzuki H, Takechi H, Takeda S, Umegaki H, Wakayama S, Arai H, J-MINT investigators: The Japan-Multimodal Intervention Trial for Prevention of Dementia (J-MINT): The Study Protocol for an 18-Month, Multicenter, Randomized, Controlled Trial The Journal of Prevention of Alzheimer's Disease. 2021.06;

  14. Takahashi Y, Nitta J, Kobori A, Sakamoto Y, Nagata Y, Tanimoto K, Matsuo S, Yamane T, Morita N, Satomi K, Inaba O, Murata K, Sasaki Y, Yoshimoto D, Kaneko M, Tanimoto Y, Isogai R, Yamashita S, Sato H, Hanazawa R, Hirakawa A, Goya M, Sasano T: Alcohol Consumption Reduction and Clinical Outcomes of Catheter Ablation for Atrial Fibrillation. Circulation: Arrhythmia and Electrophysiollogy. 2021.05; 14 (6): e009770. ( PubMed , DOI )

  15. Mori M, Watabe S, Taguchi T, Hasegawa H, Ishige M, Tanuma N, Hirakawa A, Koike R, Kusuda S: Study protocol: a multicenter, uncontrolled, open-label study of palivizumab in neonates, infants, and preschool children at high risk of severe respiratory syncytial virus infection. BMC pediatrics. 2021.03; 21 (1): 106. ( PubMed , DOI )

  16. Nagaoka E, Arai H, Ugawa T, Masuda T, Ochiai K, Tamaoka M, Kurashima N, Oi K, Fujiwara T, Yoshida M, Shigemitsu H, Otomo Y: Efficacy of Multidisciplinary Team Approach with Extracorporeal Membrane Oxygenation for COVID-19 in Low Volume ECMO center. Artificial organs. 2021.03; 45 (9): 1061-1067. ( PubMed , DOI )

  17. Yamada S, Hashizume A, Hijikata Y,Ito D, Kishimoto Y, Iida M, Koike H, Hirakawa A, Katsuno M.: Ratio of urinary N-terminal titin fragment to urinary creatinine is a novel biomarker for amyotrophic lateral sclerosis Journal of Neurology,Neurosurgery & Psyychiatry. 2021.03;

  18. Mori M, Watabe S, Taguchi T, Hasegawa H, Ishige M, Tanuma N, Hirakawa A, Koike R, Kusuda S.: Study protocol: a multicenter, uncontrolled, open-label study of palivizumab in neonates, infants, and preschool children at high risk of severe respiratory syncytial virus infection BMC Pediatrics. 2021.03; 21 (1):

  19. Ota H, Omori H, Kawasaki M, Hirakawa A, Matsuo H: Clinical impact of PCSK9 inhibitor on stabilization and regression of lipid-rich coronary plaques: a near-infrared spectroscopy study. European heart journal cardiovascular Imaging. 2021.02; 23 (2): 217-228. ( PubMed , DOI )

  20. Sano T, Kato M, Sassa N, Sadachi R, Hirakawa A, Kamihira O, Hirabayashi T, Nishikimi T, Katsuno S, Kimura T, Hattori R, Gotoh M, Tsuzuki T: pT3 subclassification of renal pelvic cancer considering the tumor location improves the patients' prognostic accuracy. Virchows Archiv : an international journal of pathology. 2021.01; 478 (6): 1089-1097. ( PubMed , DOI )

  21. Ikenouchi T, Inaba O, Takamiya T, Inamura Y, Sato A, Matsumura Y, Sato H, Hirakawa A, Takahashi Y, Goya M, Sasano T, Nitta J: The impact of left atrium size on selection of the pulmonary vein isolation method for atrial fibrillation: Cryoballoon or radiofrequency catheter ablation. American heart journal. 2021.01; 231 82-92. ( PubMed , DOI )

  22. Kato M, Hirakawa A, Sato H, Hanazawa R, Naito Y, Tochigi K, Sano T, Ishida S, Funahashi Y, Fujita T, Matsukawa Y, Hattori R, Tsuzuki T: Grade group 2 (10% ≥ GP4) patients have very similar malignant potential with grade group 1 patients, given the risk of intraductal carcinoma of the prostate. International journal of clinical oncology. 2021.01; 26 (4): 764-769. ( PubMed , DOI )

  23. Kawase Y, Omori H, Tanigaki T, Hirakawa A, Hirata T, Ota H, Kikuchi J, Sobue Y, Okubo M, Kamiya H, Kawasaki M, Suzuki T, Matsuo H: In vivo validation of resting full-cycle ratio and diastolic pressure ratio: simultaneous measurement with instantaneous wave-free ratio. Cardiovascular intervention and therapeutics. 2021.01; 36 (1): 74-80. ( PubMed , DOI )

  24. Okuma HS, Yonemori K, Kojima Y, Tanioka M, Sudo K, Noguchi E, Hijioka S, Wakakuwa K, Kato K, Hirakawa A, Kuchiba A, Kubo T, Ichikawa H, Yoshida A, Yatabe Y, Nakamura K, Mano H, Yamamoto N, Fujiwara Y: Clinical Utility of Circulating Tumor DNA in Advanced Rare Cancers. Frontiers in oncology. 2021; 11 732525. ( PubMed , DOI )

  25. Oba S, Hosoya T, Amamiya M, Mitsumura T, Kawata D, Sasaki H, Kamiya M, Yamamoto A, Ando T, Shimada S, Shirai T, Okamoto T, Tateishi T, Endo A, Aiboshi J, Nosaka N, Yamanouchi H, Ugawa T, Nagaoka E, Oi K, Tao S, Maejima Y, Tanaka Y, Tanimoto K, Takeuchi H, Tohda S, Hirakawa A, Sasano T, Arai H, Otomo Y, Miyazaki Y, Yasuda S: Arterial and Venous Thrombosis Complicated in COVID-19: A Retrospective Single Center Analysis in Japan. Frontiers in cardiovascular medicine. 2021; 8 767074. ( PubMed , DOI )

  26. Kawatsu Y, Tsuchida J, Ando S, Hirakawa A, Sozu T: Sample size determination in phase I oncology trials based on selection probability of the maximum tolerated dose. Japanese Journal of Biometrics. 2021; 42 (1): 55-64. ( DOI )

  1. Kaneko S, Hirakawa A: Assessment of Overall Treatment Effect in the Presence of Inconsistent Regional Effects in Multiregional Clinical Trials Statistics in Biopharmaceutical Research. 2020.12;

  2. Goto T, Murata M, Nishida T, Terakura S, Kamoshita S, Ishikawa Y, Ushijima Y, Adachi Y, Suzuki S, Kato K, Hirakawa A, Nishiwaki S, Nishio N, Takahashi Y, Kodera Y, Matsushita T, Kiyoi H: Phase I clinical trial of intra-bone marrow cotransplantation of mesenchymal stem cells in cord blood transplantation. Stem cells translational medicine. 2020.12; 10 (4): 542-553. ( PubMed , DOI )

  3. Kuwatsuka Y, Atsuta Y, Hirakawa A, Uchida N, Inamoto Y, Najima Y, Ikegame K, Eto T, Ozawa Y, Ichinohe T, Inoue M, Kimura T, Okamoto S, Miyamura K, Fukuda T: Use of unapproved or off-label drugs in Japan for the treatment of graft-versus-host disease and post-transplant viral infection. International journal of hematology. 2020.12; 112 (6): 841-850. ( PubMed , DOI )

  4. Kato M, Hirakawa A, Kobayashi Y, Yamamoto A, Naito Y, Tochigi K, Sano T, Ishida S, Funahashi Y, Fujita T, Matsukawa Y, Hattori R, Tsuzuki T: Effect of core needle biopsy number on intraductal carcinoma of the prostate (IDC-P) diagnosis in patients with metastatic hormone-sensitive prostate cancer. International journal of clinical oncology. 2020.12; 25 (12): 2130-2137. ( PubMed , DOI )

  5. Yokoi K, Hattori M, Satake Y, Tanaka Y, Sato M, Hashizume A, Hori A, Kawashima M, Hirakawa A, Watanabe H, Katsuno M: Longitudinal analysis of premotor anthropometric and serological markers of Parkinson's disease. Scientific reports. 2020.11; 10 (1): 20524. ( PubMed , DOI )

  6. Omori H, Kawase Y, Mizukami T, Tanigaki T, Hirata T, Kikuchi J, Ota H, Sobue Y, Miyake T, Kawamura I, Okubo M, Kamiya H, Hirakawa A, Kawasaki M, Nakagawa M, Tsuchiya K, Suzuki Y, Ito T, Terashima M, Kondo T, Suzuki T, Escaned J, Matsuo H: Comparisons of Nonhyperemic Pressure Ratios: Predicting Functional Results of Coronary Revascularization Using Longitudinal Vessel Interrogation. JACC. Cardiovascular interventions. 2020.11; 13 (22): 2688-2698. ( PubMed , DOI )

  7. Saito T, Hatta Y, Hayakawa F, Takahashi T, Hagihara M, Iida H, Minauchi K, Yamazaki E, Sugiura I, Murayama T, Sakura T, Mori N, Imai K, Yahagi Y, Atsuta Y, Saito AM, Hirakawa A, Kiyoi H, Matsumura I, Miyazaki Y, Japan Adult Leukemia Study Group.: Combination of clofarabine, etoposide, and cyclophosphamide in adult relapsed/refractory acute lymphoblastic leukemia: a phase 1/2 dose-escalation study by the Japan Adult Leukemia Study Group. International journal of hematology. 2020.11; 113 (3): 395-403. ( PubMed , DOI )

  8. Kato T, Motoji Y, Tamaki M, Inagaki M, Tsunekawa T, Hirakawa A, Okawa Y, Tomita S: Clinical benefits of fast-track rehabilitation program for patients with uncomplicated type B acute aortic dissection. General thoracic and cardiovascular surgery. 2020.11; 68 (11): 1234-1239. ( PubMed , DOI )

  9. Asano J, Hirakawa A: A Bayesian basket trial design accounting for uncertainties of homogeneity and heterogeneity of treatment effect among subpopulations. Pharmaceutical statistics. 2020.11; 19 (6): 975-1000. ( PubMed , DOI )

  10. Gotoh M, Shimizu S, Yamamoto T, Ishizuka O, Yamanishi T, Mizokami A, Narimoto K, Toriyama K, Kamei Y, Nakayama S, Kuwatsuka Y, Mizuno M, Hirakawa A: Regenerative treatment for male stress urinary incontinence by periurethral injection of adipose-derived regenerative cells: Outcome of the ADRESU study. International journal of urology : official journal of the Japanese Urological Association. 2020.10; 27 (10): 859-865. ( PubMed , DOI )

  11. Omori H, Hara M, Sobue Y, Kawase Y, Mizukami T, Tanigaki T, Hirata T, Ota H, Okubo M, Hirakawa A, Suzuki T, Kondo T, Leipsic J, Nørgaard BL, Matsuo H: Determination of the Optimal Measurement Point for Fractional Flow Reserve Derived from CT Angiography Using Pressure Wire Assessment as Reference. AJR. American journal of roentgenology. 2020.09; 216 (6): 1492-1499. ( PubMed , DOI )

  12. Okuma HS, Yonemori K, Narita SN, Sukigara T, Hirakawa A, Shimizu T, Shibata T, Kawai A, Yamamoto N, Nakamura K, Nishida T, Fujiwara Y: MASTER KEY Project: Powering Clinical Development for Rare Cancers Through a Platform Trial. Clinical pharmacology and therapeutics. 2020.09; 108 (3): 596-605. ( PubMed , DOI )

  13. Nishida Y, Hamada S, Kawai A, Kunisada T, Ogose A, Matsumoto Y, Ae K, Toguchida J, Ozaki T, Hirakawa A, Motoi T, Sakai T, Kobayashi E, Gokita T, Okamoto T, Matsunobu T, Shimizu K, Koike H: Risk factors of local recurrence after surgery in extraabdominal desmoid-type fibromatosis: A multicenter study in Japan. Cancer science. 2020.08; 111 (8): 2935-2942. ( PubMed , DOI )

  14. Takahashi Kenta, Ishibashi Eri, Kubo Toshio, Harada Yohei, Hayashi Hideyuki, Kano Masayuki, Shimizu Yasushi, Shirota Hidekazu, Mori Yukiko, Muto Manabu, Ishioka Chikashi, Dosaka-Akita Hirotoshi, Matsubara Hisahiro, Nishihara Hiroshi, Sueoka-Aragane Naoko, Toyooka Shinichi, Hirakawa Akihiro, Tateishi Ukihide, Miyake Satoshi, Ikeda Sadakatsu: A phase 2 basket trial of combination therapy with trastuzumab and pertuzumab in patients with solid cancers harboring human epidermal growth factor receptor 2 amplification (JUPITER trial) MEDICINE. 2020.08; 99 (32): e21457. ( PubMed , DOI )

  15. Ushida T, Kotani T, Hayakawa M, Hirakawa A, Sadachi R, Nakamura N, Moriyama Y, Imai K, Nakano-Kobayashi T, Kikkawa F: Antenatal corticosteroids and preterm offspring outcomes in hypertensive disorders of pregnancy: A Japanese cohort study. Scientific reports. 2020.06; 10 (1): 9312. ( PubMed , DOI )

  16. Majima S, Wakahara K, Nishio T, Nishio N, Teranishi M, Iwano S, Hirakawa A, Hashimoto N, Sone M, Hasegawa Y.: Bronchial wall thickening is associated with severity of chronic rhinosinusitis. Respiratory Medicine. 2020.05;

  17. Kawachi A, Yamashita S, Okochi-Takada E, Hirakawa A, Tsuda H, Shimomura A, Kojima Y, Yonemori K, Fujiwara Y, Kinoshita T, Ushijima T, Tamura K.: BRCA1 promoter methylation in breast cancer patients is associated with response to olaparib/eribulin combination therapy. Breast Cancer Research and Treatment. 2020.04; 181 (2): 323-329.

  18. Kaneko S, Hirakawa A, Kakurai Y, Hamada C.: A dose-finding approach for genomic patterns in phase I trials. Journal of Biopharmaceutical Statistics. 2020.04;

  19. T Hirata, T Tanigaki, Y Kawase, A Hirakawa, H Omori, S Okamoto, H Ota, Y Sobue, J Kikuchi, M Okubo, H Kamiya, M Kawasaki, T Suzuki, N H J Pijls, H Matsuo: Post-occlusional hyperemia for fractional flow reserve assessment and pull-back curve analysis. Cardiovasc Interv Ther. 2020.04; 35 (2): 142-149. ( PubMed , DOI )

  20. 小山 隆文, 清水 俊雄, 米盛 勧, 小島 勇貴, 松井 直子, 大熊 ひとみ, 野口 瑛美, 須藤 一起, 平川 晃弘, 沖田 南都子, 都祭 紗和子, 鋤柄 多美恵, 中村 健一, 田村 研治, 山本 昇, 藤原 康弘: MDM2阻害剤を用いた内膜肉腫対象医師主導治験 日本心臓血管外科学会学術総会抄録集. 2020.03; 50回 P23-3. ( ichushi )

  21. Matsumoto T, Yamamoto K, Takeuchi T, Tanaka Y, Tanaka S, Nakano T, Ito M, Tomomitsu T, Hirakawa A, Soen S: Eldecalcitol is superior to alfacalcidol in maintaining bone mineral density in glucocorticoid-induced osteoporosis patients (e-GLORIA) Journal of Bone and Mineral Metabolism. 2020.03;

  22. Nishizawa M, Onodera O, Hirakawa A, Shimizu Y, Yamada M; Rovatirelin Study Group: Effect of rovatirelin in patients with cerebellar ataxia: two randomised double-blind placebo-controlled phase 3 trials. Journal of Neurology, Neurosurgery & Psychiatry. 2020.03; 91 (3): 254-262.

  23. Kato M, Hirakawa A, Kobayashi Y, Yamamoto A, Ishida R, Kamihira O, Sano T, Majima T, Ishida S, Funahashi Y, Sassa N, Fujita T, Matsukawa Y, Hattori R, Gotoh M, Tsuzuki T: Response of intraductal carcinoma of the prostate to androgen deprivation therapy predicts prostate cancer prognosis in radical prostatectomy patients. The Prostate. 2020.02; 80 (3): 284-290.

  24. Hattori M, Tsuboi T, Yokoi K, Tanaka Y, Sato M, Suzuki K, Arahata Y, Hori A, Kawashima M, Hirakawa A, Washimi Y, Watanabe H, Katsuno M.: Subjects at risk of Parkinson’s disease in health checkup examinees: cross-sectional analysis of baseline data of the NaT-PROBE study. Journal of Neurology. 2020.02; 267 (5): 1516-1526.

  25. Okuma HS, Yonemori K, Narita SN, Sukigara T, Hirakawa A, Shimizu T, Shibata T, Kawai A, Yamamoto N, Nakamura K, Nishida T, Fujiwara Y. : MASTER KEY Project: Powering Clinical Development for Rare Cancers through a Platform Trial. Clinical Pharmacology & Therapeutics. 2020.02;

  26. Ushida T,Kotani T, Sadachi R, Hirakawa A, Hayakawa M, Moriyama Y, Imai K, Nakano-Kobayashi T, Kikkawa F, for the Neonatal Research Network of Japan: Antenatal Corticosteroids and Outcomes in Preterm Twins. Obstetrics and Gynecology. 2020.01; 135 (6): 1387-1397.

  27. Yonemori K, Tsuta K, Ono M, Shimizu C, Hirakawa A, Hasegawa T, Hatanaka Y, Narita T, Shibui S, Fujiwara Y: Disruption of the blood brain barrier by brain metastases of triple negative and basal-type breast cancer but not HER2/neu-positive breast cancer Cancer. 2020.01; 116 (2): 302-308.

  28. Soen S, Yamamoto K, Takeuchi T, Tanaka Y, Tanaka S, Ito M, Nakano T, Hagino H, Hirakawa A, Matsumoto T: Minodronate combined with alfacalcidol versus alfacalcidol alone for glucocorticoid-induced osteoporosis: a multicenter, randomized, comparative study. Journal of Bone and Mineral Metabolism. 2020.01;

  29. Sakakibara S, Hashimoto R, Katayama T, Kenjyo M, Yokokawa Y, Saito Y, Hirakawa A, Ito M, Nakamura T, Hara K, Hashizume A, Aiba I, Inukai A, Katsuno M: Longitudinal change of DAT SPECT in Parkinson’s disease and multiple system atrophy. Journal of Parkinson's Disease . 2020.01; 10 (1): 123-130.

  30. Yoshida Takuo, Uchino Shigehiko, Sasabuchi Yusuke, Hagiwara Yasuhiro, Yoshida Tomonao, Nashiki Hiroshi, Suzuki Hajime, Takahashi Hiroshi, Kishihara Yuki, Nagasaki Shinya, Okazaki Tomoya, Katayama Shinshu, Sakuraya Masaaki, Ogura Takayuki, Inoue Satoki, Uchida Masatoshi, Osaki Yuka, Kuriyama Akira, Irie Hiromasa, Kyo Michihito, Shima Nozomu, Saito Junichi, Nakayama Izumi, Jingushi Naruhiro, Nishiyama Kei, Masuda Takahiro, Tsujita Yasuyuki, Okumura Masatoshi, Inoue Haruka, Aoki Yoshitaka, Kondo Takashiro, Nagata Isao, Igarashi Takashi, Saito Nobuyuki, Nakasone Masato: Prognostic impact of sustained new-onset atrial fibrillation in critically ill patients INTENSIVE CARE MEDICINE. 2020.01; 46 (1): 27-35. ( DOI )

  31. Suzuki K, Hirakawa A, Ihara R, Iwata A, Ishii K, Ikeuchi T, Sun CK, Donohue M, Iwatsubo T, Alzheimer's Disease Neuroimaging Initiative, Japanese Alzheimer's Disease Neuroimaging Initiative.: Effect of apolipoprotein E ε4 allele on the progression of cognitive decline in the early stage of Alzheimer's disease. Alzheimer's & dementia (New York, N. Y.). 2020; 6 (1): e12007. ( PubMed , DOI )

  32. Kitase Y, Sato Y, Arai S, Onoda A, Ueda K, Go S, Mimatsu H, Jabary M, Suzuki T, Ito M, Saito A, Hirakawa A, Mukai T, Nagamura-Inoue T, Takahashi Y, Tsuji M, Hayakawa M: Establishment of a Novel Fetal Growth Restriction Model and Development of a Stem-Cell Therapy Using Umbilical Cord-Derived Mesenchymal Stromal Cells. Frontiers in cellular neuroscience. 2020; 14 212. ( PubMed , DOI )

  1. Hirakawa A, Tanaka Y, Kaneko S. : Pragmatic dose-escalation methods incorporating relative dose intensity assessment for molecularly targeted agents in phase I trials. Contemporary Clinical Trial Communications . 2019.12; 16 100489.

  2. Hirakawa A, Sudo K, Yonemori K, Sadachi R, Kinoshita F, Kobayashi Y, Okuma SH, Kawachi A, Tamura K, Fujiwara Y, Rubinstein L, Takebe N. : A comparative study of longitudinal toxicities of cytotoxic drugs, molecularly targeted agents, immunomodulatory drugs, and cancer vaccines. Clinical Pharmacology & Therapeutics. 2019.10; 106 (4): 803-809.

  3. Ito D, Hashizume A, Hijikata Y, Yamada S, Iguchi Y, Iida M, Kishimoto Y, Moriyoshi H, Hirakawa A, Katsuno M: Elevated serum creatine kinase in the early stage of sporadic amyotrophic lateral sclerosis. Journal of Neurology. 2019.08; 266 (12): 2952-2961.

  4. Kato M, Hirakawa A, Kobayashi Y, Yamamoto A, Ishida R, Sano T, Kimura T, Majima T, Ishida S, Funahashi Y, Sassa N, Fujita T, Matsukawa Y, Yamamoto T, Hattori R, Gotoh M, Tsuzuki T.: The influence of the presence of intraductal carcinoma of the prostate on the grade group system's prognostic performance. Prostate. 2019.07; 79 (10): 1065-1070.

  5. Taniguchi A, Kawada JI, Go K, Fujishiro N, Hosokawa Y, Maki Y, Sugiyama Y, Suzuki M, Tsuji T, Hoshino S, Muramatsu H, Kidokoro H, Kinoshita F, Hirakawa A, Takahashi Y, Sato Y, Natsume J, Nagoya Collaborative Clinical Research Team.: Comparison of Clinical Characteristics of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Hospitalized Young Children. Japanese journal of infectious diseases. 2019.07; 72 (4): 237-242. ( PubMed , DOI )

  6. Maeda T, Sato Y, Hirakawa A, Nakatochi M, Kinoshita F, Suzuki T, Ichimura S, Ito R, Kudo R, Suzuki M, Hoshino S, Sugiyama Y, Muramatsu H, Kidokoro H, Kawada JI, Takahashi Y: Design of a prospective multicenter randomized controlled trial evaluating the effects of gastric lavage on coffee-ground emesis in neonates: study protocol. Nagoya Journal of Medical Science. 2019.05; 81 (2): 227-232.

  7. Yokoyama T, Miyahara R, Funasaka K, Furukawa K, Yamamura T, Ohno E, Nakamura M, Kawashima H, Watanabe O, Hirooka Y, Hirakawa A, Goto H.: The utility of ultrathin endoscopy with flexible spectral imaging color enhancement for early gastric cancer. Nagoya Journal of Medical Science. 2019.05; 81 (2): 241-248.

  8. Takano N, Yamada S, Hirakawa A, Yokoyama Y, Kawashima H, Maeda O, Okada T, Ohno E, Yamaguchi J, Ishikawa T, Sonohara F, Suenaga M, Takami H, Hayashi M, Niwa Y, Hirooka Y, Ito Y, Naganawa S, Ando Y, Nagino M, Goto H, Fujii T, Kodera Y: Phase II study of chemoradiotherapy combined with gemcitabine plus nab-paclitaxel for unresectable locally advanced pancreatic ductal adenocarcinoma (NUPAT 05 Trial): study protocol for a single arm phase II study Nagoya Journal of Medical Science. 2019.05; 81 (2): 233-239.

  9. Yoshimi A, Yamada S, Kunimoto S, Aleksic B, Hirakawa A, Ohashi M, Matsumoto Y, Hada K, Itoh N, Arioka Y, Kimura H, Kushima I, Nakamura Y, Shiino T, Mori D, Tanaka S, Hamada S, Noda Y, Nagai T, Yamada K, Ozaki N: Author Correction: Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients. Translational psychiatry. 2019.05; 9 (1): 146. ( PubMed , DOI )

  10. Yoshimi A, Yamada S, Kunimoto S, Aleksic B, Hirakawa A, Ohashi M, Matsumoto Y, Hada K, Itoh N, Arioka Y, Kimura H, Kushima I, Nakamura Y, Shiino T, Mori D, Tanaka S, Hamada S, Noda Y, Nagai T, Yamada K, Ozaki N: Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients. Translational Psychiatry. 2019.04; 9 126.

  11. Ikenaka K, Atsuta N, Maeda Y, Hotta Y, Nakamura R, Kawai K, Yokoi D, Hirakawa A, Taniguchi A, Morita M, Mizoguchi K, Mochizuki H, Kimura K, Katsuno M, Sobue G.: Increase of arginine dimethylation correlates with the progression and prognosis of ALS Neurology. 2019.04; 92 (16): e1868-e1877.

  12. Shimizu S, Tsuchiya S, Hirakawa A, Kato K, Ando M, Mizuno M, Osugi M, Okabe K, Katagiri W, Hibi H.: Design of a Randomized Controlled Clinical Study of tissue-engineered osteogenic materials using bone marrow-derived mesenchymal cells for Maxillomandibular bone defects in Japan: the TEOM study protocol. BMC Oral Health. 2019.04; 19 (1): 69.

  13. Hashizume A, Katsuno M, Suzuki K, Banno H, Takeuchi Y, Kawashima M, Suga N, Mano T, Araki A, Hijikata Y, Hirakawa A, Sobue G; JASMITT study group: Efficacy and safety of leuprorelin acetate for subjects with spinal and bulbar muscular atrophy: pooled analyses of two randomized-controlled trials. Journal of Neurology. 2019.03; 266 (5): 1211-1221.

  14. Yonemori K, Shimomura A, Yasojima H, Masuda N, Aogi K, Takahashi M, Naito Y, Shimizu S, Nakamura R, Hashimoto J, Yamamoto H, Hirakawa A, Michimae H, Hamada A, Yoshida T, Sukigara T, Tamura K, Fujiwara Y.: A phase I/II trial of olaparib tablet in combination with eribulin in Japanese patients with advanced or metastatic triple-negative breast cancer previously treated with anthracyclines and taxanes. European Journal of Cancer. 2019.03; 109 84-91.

  15. Tanaka R, Yonemori K, Hirakawa A, Kinoshita F, Yamazaki N, Fujimoto M, Tamura K, Fujiwara Y.: Anti-cancer agent-induced life-threatening skin toxicities: A database study of spontaneous reporting data. The Oncologist. 2019.02; 24 (2): 266-272.

  16. Kakurai Y, Kaneko S, Hamada C, Hirakawa A (corresponding author: Dose individualization and variable selection using Bayesian Lasso in early phase dose-finding trials. Applied Statistics. 2019.02; 68 (2): 445-460.

  17. Kato M, Hirakawa A, Kobayashi Y, Yamamoto A, Ishida R, Kamihira O, Kimura T, Majima T, Ishida S, Funahashi Y, Sassa N, Fujita T, Matsukawa Y, Yamamoto T, Hattori R, Gotoh M, Tsuzuki T: Integrating Tertiary Gleason Pattern 5 into the ISUP Grading System Improves Prediction of Biochemical Recurrence in Radical Prostatectomy Patients. Modern Pathology. 2019.01; 32 (1): 122-127.

  18. Kada A, Hirakawa A (co-first author), Kinoshita F, Kobayashi Y, Hatakeyama T, Kobayashi D, Nishiyama C, Iwami T.: Sample size estimation and re-estimation of cluster randomized controlled trials for real-time feedback, debriefing, and retraining system of cardiopulmonary resuscitation for out-of-hospital cardiac arrests. Contemporary Clinical Trials Communications . 2019.01; 14 100316.

  19. Ogawa C, Sato Y, Suzuki C, Mano A, Tashiro A, Niwa T, Hamazaki S, Tanahashi Y, Suzumura M, Hayano S, Hayakawa M, Tsuji T, Hoshino S, Sugiyama Y, Kidokoro H, Kawada JI, Muramatsu H, Hirakawa A, Ando M, Natsume J, Kojima S: Correction: Treatment with silver nitrate versus topical steroid treatment for umbilical granuloma: A non-inferiority randomized control trial. PloS one. 2019; 14 (6): e0218205. ( PubMed , DOI )

  1. Hirakawa A, Asano J, Sato H, Teramukai S: Master protocol trials in oncology: Review and new trial designs. Contemporary Clinical Trial Communication. 2018.12; 12 1-8. ( PubMed , DOI )

  2. 川村 一太, 梶浦 涼, 平川 晃弘, 近藤 武, 鈴木 孝彦, 松尾 仁司: D-SPECTによる安静Tc/負荷Tl　2核種同時撮像プロトコールの診断能 核医学. 2018.11; 55 (Suppl.): S175. ( ichushi )

  3. Saji N, Sakurai T, Ito K, Tomimoto H, Kitagawa K, Miwa K, Tanaka Y, Kozaki K, Kario K, Eto M, Suzuki K, Shimizu A, Niida S, Hirakawa A, Toba K; Strawberry study investigators: Protective effects of oral anticoagulants on cerebrovascular diseases and cognitive impairment in patients with atrial fibrillation: protocol for a multicentre, prospective, observational, longitudinal cohort study (Strawberry study). BMJ Open. 2018.11; 8 (11): e021759.

  4. Sato Y, Ueda K, Kondo T, Hattori T, Mikrogeorgiou A, Sugiyama Y, Suzuki T, Yamamoto M, Hirata H, Hirakawa A, Nakanishi K, Tsuji M, Hayakawa M: Administration of Bone Marrow-Derived Mononuclear Cells Contributed to the Reduction of Hypoxic-Ischemic Brain Injury in Neonatal Rats. Frontiers in Neurology. 2018.11; 9 987.

  5. Kawamura I, Kajiura R, Motoji Y, Okamoto S, Tanigaki T, Omori H, Hirata T, Kikuchi J, Ota H, Sobue Y, Miyake T, Tsunekawa T, Kato T, Kawase Y, Okubo M, Kamiya H, Tsuchiya K, Tomita S, Hirakawa A, Kondo T, Suzuki T, Matsuo H: Diagnostic Performance of the Simultaneous Acquisition Rest 99mTc-Tetrofosmin/Stress 201Tl Dual Isotope Protocol with a Semiconductor Camera: Comparison with the Rest-Stress 99mTc-Tetrofosmin Protocol. Circulation Journal. 2018.10; 82 (11): 2837-2844.

  6. Sakamoto Y, Okamoto S, Shimizu K, Araki Y, Hirakawa A, Wakabayashi T.: Comparative Prospective Study of Microvascular Anastomosis Training by Self-Learning or with Expert Instruction. World Neurosurgery. 2018.10; 118 e818-e824.

  7. Hirakawa A, Hatakeyama T, Kobayashi D, Nishiyama C, Kada A, Kiguchi T, Kawamura T, Iwami T: Real-time feedback, debriefing, and retraining system of cardiopulmonary resuscitation for out-of-hospital cardiac arrests: a study protocol for a cluster parallel-group randomized controlled trial. Trials. 2018.09; 19 (1): 510. ( PubMed , DOI )

  8. Tsuda H, Kotani T, Nakano T, Imai K, Ushida T, Hirakawa A, Kinoshita F, Takahashi Y, Iwagaki S, Kikkawa F. : The rate of neonatal respiratory distress syndrome/transient tachypnea in the newborn and the amniotic lamellar body count in twin pregnancies compared with singleton pregnancies. Clinica Chimica Acta. 2018.09; 484 293-297.

  9. Tsuda H, Kotani T, Nakano T, Imai K, Ushida T, Hirakawa A, Kinoshita F, Takahashi Y, Iwagaki S, Kikkawa F: The impact of fertility treatment on the neonatal respiratory outcomes and amniotic lamellar body counts in twin pregnancies. Clinica Chimica Acta. 2018.09; 484 192-196.

  10. Yamada S, Hashizume A, Hijikata Y, Inagaki T, Ito D, Kinoshita F, Nakatochi M, Kobayashi Y, Hirakawa A, Nakamura T, Katsuno M.: Study protocol for the MEXiletine hydrochloride administration trial: A placebo-controlled, randomised, double-blind, multicentre, crossover study of its efficacy and safety in spinal and bulbar muscular atrophy (MEXPRESS). BMJ Open. 2018.09; 8 (9): e023041.

  11. Yamada S, Fujii T, Hirakawa A, Takami H, Suenaga M, Hayashi M, Niwa Y, Hattori N, Iwata N, Kanda M, Tanaka C, Kobayashi D, Nakayama G, Koike M, Fujiwara M, Kodera Y: Comparison of the Survival Outcomes of Pancreatic Cancer and Intraductal Papillary Mucinous Neoplasms. Pancreas. 2018.09; 47 (8): 974-979. ( PubMed , DOI )

  12. Hirakawa A, Asano J, Sato H, Teramukai S.: Master protocol trials in oncology: Review and new trial designs. Contemporary Clinical Trial Communication. 2018.08; 12 1-8.

  13. Moritoki Egi, Jun Kataoka, Takashi Ito, Osamu Nishida, Hideto Yasuda, Hiroshi Okamaoto, Akira Shimoyama, Masayo Izawa, Shinsaku Matsumoto, Nana Furushima, Shigeki Yamashita, Koji Takada, Masahide Ohtsuka, Noritomo Fujisaki, Nobuaki Shime, Nobuhiro Inagaki, Yasuhiko Taira, Tomoaki Yatabe, Kenichi Nitta, Takeshi Yokoyama, Shigeki Kushimoto, Kentaro Tokunaga, Matsuyuki Doi, Takahiro Masuda, Yasuo Miki, Kenichi Matsuda, Takehiko Asaga, Keita Hazama, Hiroki Matsuyama, Masaji Nishimura, Satoshi Mizobuchi, : Oxygen management in mechanically ventilated patients: A multicenter prospective observational study. J Crit Care. 2018.08; 46 1-5. ( PubMed , DOI )

  14. Kawase Y, Tanigaki T, Hirakawa A, Omori H, Hirata T, Okamoto S, Ota H, Kikuchi J, Okubo M, Kamiya H, Kawasaki M, Suzuki T, Matsuo H: Frequency of a large drift caused by pressure wire using optical fibers Cardiovascular Intervention and Therapeutics. 2018.07; 33 (3): 270-276.

  15. Kawase Y, Kawasaki M, Kikuchi J, Hirata T, Okamoto S, Tanigaki T, Omori H, Ota H, Okubo M, Kamiya H, Hirakawa A, Matsuo H: Residual pressure gradient across the implanted stent: An important factor of post-PCI physiological results. Journal of Cardiology. 2018.05; 71 (5): 458-463.

  16. Hyodo R, Sato Y, Ito M, Sugiyama Y, Ogawa C, Kawai H, Nakane T, Saito A, Hirakawa A, Kidokoro H, Natsume J, Hayakawa M: Magnetic resonance spectroscopy in preterm infants: association with neurodevelopmental outcomes Archives of Disease in Childhood. 2018.05; 103 (3): f238-f244.

  17. Kimura K, Itoh Y, Okada T, Kubota S, Kawamura M, Nakahara R, Oie Y, Kozai Y, Takase Y, Tsuzuki H, Nishio N, Hiramatsu M, Fujimoto Y, Mizutani T, Hirakawa A, Naganawa S: Study Protocol: Prospective Study of Concurrent Chemoradiotherapy with S-1 and Hypofractionated Radiotherapy for Outpatients with Early Glottic Squamous Cell Carcinomas Asian Pacific journal of cancer prevention : APJCP. 2018.05; 19 (5): 1195-1199. ( PubMed , DOI )

  18. Hirakawa A, Nishikawa T, Yonemori K, Shibata T, Nakamura K, Ando M, Ueda T, Ozaki T, Tamura K, Kawai A, Fujiwara Y.: Utility of Bayesian single-arm design in new drug application for rare cancers in Japan: a case study of phase 2 trial for sarcoma. Therapeutic Innovation & Regulatory Science. 2018.05; 52 (3): 334-338.

  19. Ozeki N, Fukui T, Kawaguchi K, Nakamura S, Hakiri S, Kato T, Hirakawa A, Yokoi K: A survival analysis using physique-adjusted tumor size of non-small cell lung cancer International Journal of Clinical Oncology. 2018.04; 23 (2): 266-274.

  20. Hijikata Y, Hashizume A, Yamada S, Inagaki T, Ito D, Hirakawa A, Suzuki K, Atsuta N, Tsuboi T, Hattori M, Hori A, Banno H, Sobue G, Katsuno M: Biomarker-based analysis of preclinical progression in spinal and bulbar muscular atrophy Neurology. 2018.04; 90 (17): e1501-e1509.

  21. Ohsawa Y, Hagiwara H, Nishimatsu SI, Hirakawa A, Kamimura N, Ohtsubo H, Fukai Y, Murakami T, Koga Y, Goto YI, Ohta S, Sunada Y; KN01 Study Group: Taurine supplementation for prevention of stroke-like episodes in MELAS: a multicentre, open-label, 52-week phase III trial. Journal of Neurology, Neurosurgery, and Psychiatry. 2018.04; 90 (5): 529-536.

  22. Goto T, Murata M, Terakura S, Nishida T, Adachi Y, Ushijima Y, Shimada K, Ishikawa Y, Hayakawa F, Nishio N, Nishiwaki S, Hirakawa A, Kato K, Takahashi Y, Kiyoi H: Phase I study of cord blood transplantation with intra-bone marrow injection of mesenchymal stem cells: A clinical study protocol. Medicine. 2018.04; 97 (17): e0449.

  23. Hijikata Y, Katsuno M, Suzuki K, Hashizume A, Araki A, Yamada S, Inagaki T, Ito D, Hirakawa A, Kinoshita F, Gosho M, Sobue G: Treatment with Creatine Monohydrate in Spinal and Bulbar Muscular Atrophy: Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial. JMIR research protocols. 2018.03; 7 (3): e69. ( PubMed , DOI )

  24. Imai K, Kotani T, Nakano T, Ushida T, Hirakawa A, Kikkawa F.: Maternal protein S activity is associated with massive hemorrhage during Caesarean section: Retrospective case-control study. The Journal of Maternal-Fetal & Neonatal Medicine,. 2018.02; 32 (16): 2633-2637.

  25. Ogawa C, Kidokoro H, Fukasawa T, Yamamoto H, Ishihara N, Ito Y, Sakaguchi Y, Okai Y, Ohno A, Nakata T, Azuma Y, Hattori A, Kubota T, Tsuji T, Hirakawa A, Kawai H, Natsume J: Cytotoxic edema at onset in West syndrome of unknown etiology: a longitudinal DTI study Epilepsia. 2018.02; 59 (2): 440-448.

  26. Ogawa C, Sato Y, Suzuki C, Mano A, Tashiro A, Niwa T, Hamazaki S, Tanahashi Y, Suzumura M, Hayano S, Hayakawa M, Tsuji T, Hoshino S, Sugiyama Y, Kidokoro H, Kawada JI, Muramatsu H, Hirakawa A, Ando M, Natsume J, Kojima S: Treatment with silver nitrate versus topical steroid treatment for umbilical granuloma: a non-inferiority randomized control trial. PLOS ONE. 2018.02; 13 (2): e0192688.

  27. Shimamura F, Hamada C, Matsui S, Hirakawa A(corresponding author): Two-stage approach based on zone and dose findings for two-agent combination Phase I/II trials. Journal of Biopharmaceutical Statistics. 2018.02; 28 (６): 1025-1037.

  28. Hirakawa A, Yonemori K, Kinoshita F, Kobayashi Y, Okuma HS, Kawachi A, Tamura K, Fujiwara Y, Rubinstein L, Harris PJ, Takebe N: Potential utility of a longitudinal relative dose intensity of molecularly targeted agents in phase 1 dose-finding trials. Cancer science. 2018.01; 109 (1): 207-214. ( PubMed , DOI )

  29. Kato M, Kimura K, Hirakawa A, Kobayashi Y, Ishida R, Kamihira O, Majima T, Funahashi Y1, Sassa N, Matsukawa Y, Hattori R, Gotoh M, Tsuzuki T: Prognostic parameter for high risk prostate cancer patients at initial presentation Prostate. 2018.01; 78 (1): 11-16.

  1. Kawase Y, Kawasaki M, Tanigaki T, Omori H, Hirata T, Okamoto S, Ota H, Kikuchi J, Okubo M, Kamiya H, Hirakawa A, Suzuki T, Matsuo H: Postocclusional hyperemia for fractional flow reserve after percutaneous coronary intervention JACC-Cardiovascular Interventions. 2017.12; 10 (12): e005674.

  2. Hashizume A, Katsuno M, Suzuki K, Hirakawa A, Hijikata Y, Yamada S, Inagaki T, Banno H, Sobue G: Long-term treatment with leuprorelin for spinal and bulbar muscular atrophy: natural history-controlled study. Journal of neurology, neurosurgery, and psychiatry. 2017.12; 88 (12): 1026-1032. ( PubMed , DOI )

  3. Nomura S, Hirakawa A, Hamada C.: Sample size determination for the current strategy in oncology phase 3 trials that tests progression-free survival and overall survival in a two-stage design framework. Journal of Biopharmaceutical Statistics. 2017.12; 28 (4): 589-611.

  4. Ozeki N, Kawaguchi K, Fukui T, Fukumoto K, Nakamura S, Hakiri S, Kato T, Hirakawa A, Okasaka T, Yokoi K: The diffusing capacity of the lung for carbon monoxide is associated with the histopathological aggressiveness of lung adenocarcinoma European Journal of Cardio-Thoracic Surgery. 2017.11; 52 (5): 969-974.

  5. Chantarojanasiri T, Hirooka Y, Kawashima H, Ohno E, Kuwahara T, Yamamura T, Funasaka K, Nakamura M, Miyahara R, Ishigami M, Watanabe O, Hashimoto S, Hirakawa A, Ratanachu-ek T, Goto H: Endoscopic ultrasound in diagnosis of solid pancreatic lesions: Elastography or contrast-enhanced harmonic alone versus the combination Endoscopy International Open. 2017.11; 5 (11): e1136-e1143.

  6. Yokoi A, Yoshioka Y, Hirakawa A, Yamamoto Y, Ishikawa M, Ikeda S, Kato T, Niimi K, Kajiyama H, Kikkawa F, Ochiya T: A combination of circulating miRNAs for the early detection of ovarian cancer Oncotarget. 2017.10; 8 (52): 89811-89823.

  7. Miyamoto K, Ohkawara B, Ito M, Masuda A, Hirakawa A, Sakai T, Hiraiwa H, Hamada T, Ishiguro N, Ohno K: Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling PLoS One. 2017.09; 12 (9): e0184388.

  8. Shimizu S, Yamamoto T, Nakayama S, Hirakawa A, Kuwatsuka Y, Funahashi Y, Matsukawa Y, Takanari K, Toriyama K, Kamei Y, Narimoto K, Yamanishi T, Ishizuka O, Mizuno M, Gotoh M: Design of a single-arm clinical trial of regenerative therapy by periurethral injection of adipose-derived regenerative cells for male stress urinary incontinence in Japan: the ADRESU study protocol BMC Urology. 2017.09; 17 (1): 89.

  9. Kato T, Tamaki M, Tsunekawa T, Motoji Y, Hirakawa A, Okawa Y, Tomita S: Health-Related Quality of Life Prospectively Evaluated by the 8-item Short Form After Endovascular Repair Versus Open Surgery for Abdominal Aortic Aneurysms Heart Vessel. 2017.08; 32 (8): 960-968.

  10. Shimura M, Gosho M, Hirakawa A.: Comparison of conditional bias-adjusted estimators for interim analysis in clinical trials with survival data. Statistics in Medicine. 2017.06; 36 (13): 2067-2080.

  11. Sakamoto Y, Okamoto S, Shimizu K, Araki Y, Hirakawa A, Wakabayashi T: Hands-on simulation versus traditional video-learning in teaching microsurgery technique Neurologia Medico-Chirurgica. 2017.05; 57 (5): 238-245.

  12. Kato T, Tsunekawa T, Motoji Y, Hirakawa A, Okawa Y, Tomita S: The side-to-side fashion for individual distal coronary anastomosis using venous conduit Heart and Vessels. 2017.04; 32 (4): 385-389.

  13. Nakanishi K, Sato Y, Mizutani Y, Ito M, Hirakawa A, Higashi Y: Rat umbilical cord blood cells attenuate hypoxic-ischemic brain injury in neonatal rats Scientific Reports. 2017.03;

  14. Imai K, Kotani T, Tsuda H, Nakano T, Hirakawa A, Kikkawa F: A Novel Approach to Detecting Postpartum Hemorrhage Using Contrast-Enhanced Ultrasound Ultrasound in medicine and biology. 2017.03; 43 (3): 615-620.

  15. 谷垣 徹, 川瀬 世史明, 平川 晃弘, 岡本 修一, 大森 寛行, 平田 哲夫, 菊地 淳, 太田 秀彰, 三宅 泰次, 川村 一太, 大久保 宗則, 松尾 仁司: 計算による冠血流予備量比の診断性能の比較　三次元定量的冠動脈造影と冠動脈CT血管造影の比較(Comparison of Diagnostic Performance of Computed Fractional Flow Reserve: 3-Dimentional Quantitative Coronary Angiography versus Coronary Computed Tomography Angiography) 日本循環器学会学術集会抄録集. 2017.03; 81回 OJ-134. ( ichushi )

  16. Hirakawa A, Kinoshita F: An Analysis of Japanese Patients Enrolled in Multiregional Clinical Trials in Oncology. Therapeutic innovation & regulatory science. 2017.03; 51 (2): 207-211. ( PubMed , DOI )

  17. Yamasaki S, Hirakawa A, Aoki J, Uchida N, Fukuda T, Ogawa H, Ohashi K, Kondo T, Eto T, Kanamori H, Okumura H, Iwato K, Ichinohe T, Kanda J, Onizuka M, Kuwatsuka Y, Yanada M, Atsuta Y, Takami A, Yano S: Role of reduced-intensity conditioning allogeneic hematopoietic cell transplantation in older patients with de novo acute myeloid leukemia Annals of Hematology. 2017.02; 96 (2): 289-297.

  18. Miyauchi R, Itoh Y, Kawamura M, Hirakawa A, Shibata K, Kajiyama H, Nakahara R, Kubota S, Ito J, Okada T, Kikkawa F, Naganawa S: Postoperative chemoradiation therapy using high dose cisplatin and fluorouracil for high- and intermediate-risk uterine cervical cancer Nagoya Journal of Medical Science. 2017.02; 79 (2): 211-220.

  19. Asano J, Hirakawa A (co-first author): Assessing the prediction accuracy of a cure model for censored survival data with long-term survivors: application to breast cancer data. Journal of Biopharmaceutical Statistics. 2017.02; 27 (6): 918-932.

  20. Gosho M, Maruo K, Tada K, Hirakawa A.: Utilization of chi-square statistics for screening adverse drug-drug interactions in spontaneous reporting systems. European Journal of Clinical Pharmacology. 2017.01; 73 (6): 779-786.

  21. Sawamura A, Okumura T, Hirakawa A, Ito M, Ozaki Y, Ohte N, Amano T, Murohara T; CHANGE PUMP Investigators: Early Prediction Model for Successful Bridge to Recovery in Patients With Fulminant Myocarditis Supported With Percutaneous Venoarterial Extracorporeal Membrane Oxygenation - Insights From the CHANGE PUMP Study Circulation Journal. 2017; 82 (3): 699-707.

  1. Yamada S, Hashizume A, Hijikata Y, Inagaki T, Suzuki K, Kondo N, Kawai K, Noda S, Nakanishi H, Banno H, Hirakawa A, Koike H, Halievski K, Jordan CL, Katsuno M, Sobue G: Decreased Peak Expiratory Flow Associated with Muscle Fiber-Type Switching in Spinal and Bulbar Muscular Atrophy PLoS One. 2016.12; 11 (12): e0168846.

  2. Yamada S, Fujii T, Hirakawa A, Kanda M, Sugimoto H, Kodera Y: Lymph node ratio as parameter of regional lymph node involvement in pancreatic cancer Langenbeck's Archives of Surgery. 2016.12; 401 (8): 143-1152.

  3. Yonemori K, Hirakawa A (co-first author), Kawachi A, Kinoshita F, Ohkuma H, Nishikawa T, Kenji T, Fujiwara Y, Takebe N. : Drug induced Interstitial Lung Disease in Oncology Phase I Trials. Cancer Science. 2016.12; 107 (12): 1830-1836.

  4. Fukui T, Fukumoto K, Okasaka T, Kawaguchi K, Nakamura S, Hakiri S, Ozeki N, Hirakawa A, Tateyama H, Yokoi K: Prognostic impact of tumour size in completely resected thymic epithelial tumours European Journal of Cardio-Thoracic Surgery. 2016.12; 50 (6): 1068-1074.

  5. Hirakawa A, Sato H, Gosho M: Effect of design specifications in dose-finding trials for combination therapies in oncology. Pharmaceutical Statistics. 2016.11; 15 (6): 531-540. ( PubMed , DOI )

  6. Hirakawa A, Sato H, Gosho M.: Effect of design specifications in dose-finding trials for combination therapies in oncology. Pharmaceutical Statistics. 2016.11; 15 (6): 531-540.

  7. Gosho M, Maruo K, Ishii R, Hirakawa A: Analysis of an incomplete longitudinal composite variable using a marginalized random effects model and multiple imputation. Statistical Methods in Medical Research. 2016.11; 27 (7): 2200-2215.

  8. Sato H, Hirakawa A (co-first author), Hamada C: An adaptive dose-finding method using a change-point model for molecularly targeted agents in phase I trials. Statistics in Medicine. 2016.10; 35 (23): 4093-4109. ( PubMed , DOI )

  9. Sato H, Hirakawa A (co-first author), Hamada C: An adaptive dose-finding method using a change-point model for molecularly targeted agents in phase I trials. Statistics in Medicine. 2016.10; 35 (23): 4093-4109.

  10. Atsuta Y, Hirakawa A, Nakasone H, Kurosawa S, Oshima K, Sakai R, Ohashi K, Takahashi S, Mori T, Ozawa Y, Fukuda T, Kanamori H, Morishima Y, Kato K, Yabe H, Sakamaki H, Taniguchi S, Yamashita T: Late mortality and causes of death among long-term survivors after allogeneic stem cell transplantation Biology of Blood and Marrow Transplantation. 2016.09; 22 (9): 1702-1709.

  11. Harano K, Yonemori K, Hirakawa A: The influence of familial factors on the choice of the place of death for terminally ill breast cancer patients: a retrospective single-center study Breast Cancer. 2016.09; 23 (5): 797-806.

  12. Okuma H, Koizumi F, Hirakawa A, Nakatochi M, Komori O, Hashimoto J, Kodaira M, Yunokawa M, Yamamoto H, Yonemori K, Shimizu C, Fujiwara Y, Tamura K: Clinical and microarray analysis of breast cancers of all subtypes from two prospective preoperative chemotherapy studies British Journal of Cancer. 2016.08; 115 (4): 411-419.

  13. Watanabe H, Atsuta N, Hirakawa A (co-first author), Nakamura R, Nakatochi M, Ishigaki S, Iida A, Ikegawa S, Kubo M, Yokoi D, Watanabe H, Ito M, Katsuno M, Izumi Y, Morita M, Kanai K, Taniguchi A, Aiba I, Abe K, Mizoguchi K, Oda M, Kano O, Okamoto K, Kuwabara S, Hasegawa K, Imai T, Kawata A, Aoki M, Tsuji S, Nakashima K, Kaji R, Sobue G: A rapid functional decline type of amyotrophic lateral sclerosis is linked to low expression of TTN Journal of Neurology, Neurosurgery, and Psychiatry. 2016.08; 87 (8): 851-858.

  14. Shimada K, Shimada S, Sugimoto K, Nakatochi M, Suguro M, Hirakawa A, Hocking TD, Takeuchi I, Tokunaga T, Takagi Y, Sakamoto A, Aoki T, Naoe T, Nakamura S, Hayakawa F, Seto M, Tomita A, Kiyoi H: Development and analysis of patient-derived xenograft mouse models in intravascular large B-cell lymphoma Leukemia. 2016.07; 30 (7): 1568-1579.

  15. Hijikata Y, Katsuno M, Suzuki K, Hashizume A, Araki A, Yamada S, Inagaki T, Iida M, Noda S, Nakanishi H, Banno H, Mano T, Hirakawa A, Adachi H, Watanabe H, Yamamoto M, Sobue G: Impaired muscle uptake of creatine in spinal and bulbar muscular atrophy Annals of Clinical and Translational Neurology. 2016.06; 23 (3): 537-546.

  16. Harano K, Hirakawa A, Yunokawa M, Nakamura T, Satoh T, Nishikawa T, Aoki D, Ito K, Ito K, Nakanishi T, Susumu N, Takehara K, Watanabe Y, Watari H, Saito T: Optimal cytoreductive surgery in patients with advanced uterine carcinosarcoma: A multi-institutional retrospective study from the Japanese gynecologic oncology group Gynecologic Oncology. 2016.06; 141 (3): 447-453.

  17. Yokoi D, Atsuta N, Watanabe H, Nakamura R, Hirakawa A, Ito M, Watanabe H, Katsuno M, Izumi Y, Morita M, Taniguchi A, Oda M, Abe K, Mizoguchi K, Kano O, Kuwabara S, Kaji R, Sobue G; JaCALS: Age of onset differentially influences the progression of regional dysfunction in sporadic amyotrophic lateral sclerosis Journal of Neurology. 2016.06; 263 (6): 1129-1136.

  18. Nagata T, Sobajima H, Ohashi N, Hirakawa A, Katsuno T, Yasuda Y, Matsuo S, Tsuboi N, Maruyama S: Association between 24h Urinary Sodium and Potassium Excretion and Estimated Glomerular Filtration Rate (eGFR) Decline or Death in Patients with Diabetes Mellitus and eGFR More than 30 ml/min/1.73m2 PLoS ONE. 2016.05; 11 (5): e0152306.

  19. Tanaka R, Yonemori K, Hirakawa A, Kinoshita F, Takahashi N, Hashimoto J, Kodaira M, Yamamoto H, Yunokawa M, Shimizu C, Fujimoto M, Fujiwara Y, Tamura K: Risk factors for developing skeletal-related events in breast cancer patients with bone metastases undergoing treatment with bone-modifying agents Oncologist. 2016.04; 21 (4): 508-513.

  20. Chieko Mitaka, Takahiro Masuda, Koji Kido, Tokujiro Uchida, Shinya Abe, Taku Miyasho, Makoto Tomita, Eiichi Inada: Polymyxin B hemoperfusion prevents acute kidney injury in sepsis model. J. Surg. Res.. 2016.03; 201 (1): 59-68. ( PubMed , DOI )

  21. Kato M, Tsuzuki T, Kimura K, Hirakawa A, Kinoshita F, Sassa N, Ishida R, Fukatsu A, Kimura T, Funahashi Y, Matsukawa Y, Hattori R, Gotoh M: The presence of intraductal carcinoma of the prostate in needle biopsy is a significant prognostic factor for prostate cancer patients with distant metastasis at initial presentation Modern Pathology. 2016.02; 29 (2): 166-173.

  22. Imai K, Kotani T, Tsuda H, Mano Y, Nakano T, Ushida T, Li H, Miki R, Sumigama S, Iwase A, Hirakawa A, Ohno K, Toyokuni S, Takeuchi H, Mizuno T, Suzumura A, Kikkawa F: Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia Free Radical Biology & Medicine. 2016.02; 91 154-163.

  23. Matsukawa Y, Takai S, Funahashi Y, Kato M, Yamamoto T, Hirakawa A, Gotoh M: The Change of Testosterone Secretion During the Treatment of Alpha-1 Blocker in Patients with Benign Prostatic Hyperplasia Urology. 2016.02; 88 149-154.

  24. Fukui T, Fukumoto K, Okasaka T, Kawaguchi K, Nakamura S, Hakiri S, Ozeki N, Hirakawa A, Tateyama H, Yokoi K: Clinical evaluation of a new tumour-node-metastasis staging system for thymic malignancies proposed by the International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and the International Thymic Malignancy Interest Group European Journal of Cardio-Thoracic Surgery. 2016.02; 49 (2): 575-579.

  25. Hirakawa A, Sato H. : Authors' Reply: Response to Letter to the Editor by Drs Riviere et al. Statistics in Medicine. 2016.02; 35 (3): 479-480.

  26. Harano K, Hirakawa A, Yunokawa M, Nakamura T, Satoh T, Nishikawa T, Aoki D, Ito K, Ito K, Nakanishi T, Susumu N, Takehara K, Watanabe Y, Watari H, Saito T: Prognostic factors in patients with uterine carcinosarcoma: a multi-institutional retrospective study from the Japanese Gynecologic Oncology Group International Journal of Clinical Oncology. 2016.02; 21 168-176.

  27. Nagai S, Urata M, Sato H, Mikami M, Kuga W, Yanagihara R, Miyamoto D, Suzuki Y, Shikano M: Evolving Japanese regulations on companion diagnostics. Nature Biotechnology. 2016.02; 34 (2): 141-144. ( PubMed , DOI )

  28. Hirakawa A, Sato H: Authors' Reply. Statistics in Medicine. 2016.02; 35 (3): 479-480. ( PubMed , DOI )

  1. Tsuda H, Hirakawa A, Kotani T, Sumigama S, Mano Y, Nakano T, Imai K, Kawabata I, Takahashi Y, Iwagaki S, Kikkawa F: Risk assessment for neonatal RDS/TTN using gestational age and the amniotic lamellar body count in twin pregnancies Clinica Chimica Acta. 2015.12; 7 (451): 301-304.

  2. Nakano T, Kotani T, Mano Y, Tsuda H, Imai K, Ushida T, Li H, Miki R, Sumigama S, Sato Y, Iwase A, Hirakawa A, Asai M, Toyokuni S, Kikkawa F: Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury Journal of Clinical Biochemistry and Nutrition. 2015.11; 57 (3): 178-182.

  3. Hirakawa A, Wages NA, Sato H, Matsui S: A comparative study of adaptive dose-finding designs for phase I oncology trials of combination therapies. Statistics in Medicine. 2015.10; 34 (24): 3194-3213. ( PubMed , DOI )

  4. Takafumi Ohmori, Nobuhiro Shiota, Akihiro Haramo, Takahiro Masuda, Fumi Maruyama, Kenji Wakabayashi, Yushi U Adachi, Koichi Nakazawa: Post-operative cardiac arrest induced by co-administration of amiodarone and dexmedetomidine: a case report. J Intensive Care. 2015.10; 3 (10): 43. ( PubMed , DOI )

  5. Suzuki N, Takedani H, Hirakawa A, Ushijima Y, Matsushita T: The features of clearance in recombinant factor IX (BeneFIX®) Haemophilia. 2015.09; 21 (5): 702-707.

  6. Gosho M, Hirakawa A, Maruo K, Noma H, Sato Y.: Comparison of bias-corrected covariance estimators for MMRM analysis in longitudinal data with dropouts. Statistical Method in Medical Research. 2015.08; 26 (5): 2389-2406.

  7. Kakurai Y, Hirakawa A, Hamada C.: A dose-finding method based on multiple dosing in two-agent combination phase I trials Journal of Biopharmaceutical Statistics. 2015.07; 25 (5): 1065-1076.

  8. Hashizume A, Katsuno M, Suzuki K, Banno H, Suga N, Mano T, Araki A, Hijikata Y, Grunseich C, Kokkinis A, Hirakawa A, Watanabe H, Yamamoto M, Fischbeck KH, Sobue G: A functional scale for spinal and bulbar muscular atrophy: cross-sectional and longitudinal study Neuromuscular Disorders. 2015.07; 25 (7): 554-562.

  9. Nakamura S, Fukui T, Kawaguchi K, Fukumoto K, Hirakawa A, Yokoi K: Does ground glass opacity-dominant feature have a prognostic significance even in clinical T2aN0M0 lung adenocarcinoma? Lung Cancer. 2015.07; 89 (1): 38-42.

  10. Kaneko S, Hirakawa A, Hamada C. : Enhancing the Lasso approach for developing a survival prediction model based on gene expression data. Computational and Mathematical Methods in Medicine. 2015.06; 2015 (259474):

  11. Kato T, Iwano S, Taniguchi T, Kawaguchi K, Fukui T, Ishiguro F, Fukumoto K, Nakamura S, Hirakawa A, Yokoi K: The contact length between the tumor contour and the lung on computed tomography is a risk factor for pleural recurrence after complete resection of thymoma General Thoracic and Cardiovascular Surgery. 2015.06; 63 (6): 343-348.

  12. Watanabe H, Atsuta N, Nakamura R, Hirakawa A (co-first author), Watanabe H, Ito M, Senda J, Katsuno M, Izumi Y, Morita M, Tomiyama H, Taniguchi A, Aiba I, Abe K, Mizoguchi K, Oda M, Kano O, Okamoto K, Kuwabara S, Hasegawa K, Imai T, Aoki M, Tsuji S, Nakano I, Kaji R, Sobue G: Factors affecting longitudinal functional decline and survival in amyotrophic lateral sclerosis patients Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 2015.06; 16 (3-4): 230-236.

  13. Hirakawa A, Wages NA, Sato H, Matsui S.: A comparative study of adaptive dose-finding designs for phase I oncology trials of combination therapies. Statistics in Medicine. 2015.05; 34 (24): 3194-3213.

  14. Okada N, Tajima K, Takami Y, Kato W, Kei F, Hibino M, Munakata H, Sakai Y, Hirakawa A, Usui A.: Valve selection for the aortic position in dialysis patients. The Annals of Thoracic Surgery. 2015.05; 99 (5): 1524-1531.

  15. Hirakawa A and Matsui S.: Operating characteristics of restrictions on skipping dose level for adaptive dose-finding method in two-agent phase I trials. Japanese Journal of Biometrics. 2015.04; 36 (1): 1-12.

  16. Hattori T, Sato Y, Kondo T, Ichinohashi Y, Sugiyama Y, Yamamoto M, Kotani T, Hirata H, Hirakawa A, Suzuki S, Tsuji M, Ikeda T, Nakanishi K, Kojima S, Blomgren K, Hayakawa M: Administration of umbilical cord blood cells transiently decreased　hypoxic-ischemic brain injury in neonatal rats Developmental Neuroscience. 2015.02; 37 (2): 95-104.

  17. Tsuda H, Kotani T, Sumigama S, Mano Y, Kawabata I, Takahashi Y, Iwagaki S, Hirakawa A, Kikkawa F: Amniotic lamellar body count: predicting and distinguishing neonatal respiratory complications in twin pregnancies Clinica Chimica Acta. 2015.02; 441 (20): 75-78.

  18. Kataoka Y, Nishida S, Hirakawa A, Oiso Y, Arima H: Comparison of incidence of hyponatremia between intranasal and oral desmopressin in patients with central diabetes insipidus Endocrine Journal. 2015; 62 (2): 195-200.

  1. Ozeki N, Iwano S, Taniguchi T, Kawaguchi K, Fukui T, Ishiguro F, Fukumoto K, Nakamura S, Hirakawa A, Yokoi K: Therapeutic surgery without a definitive diagnosis can be an option in selected patients with suspected lung cancer Interactive Cardiovascular and Thoracic Surgery. 2014.11; 19 (5): 830-837.

  2. Asano J, Hirakawa A, Hamada C: Assessing the prediction accuracy of cure in the Cox proportional hazards cure model: an application to breast cancer data. Pharmaceutical Statistics. 2014.07; 13 (6): 357-363.

  3. Goto M, Yamamoto T, Kato M, Majima T, Toriyama K, kamei Y, Matsukawa Y, Hirakawa A, Funahashi Y: Regenerative treatment of male stress urinary incontinence by periurethral injection of autologous adipose-derived regenerative cells: 1-year outcomes in 11 patients International Journal of Urology. 2014.05; 21 (3): 294-300.

  4. Yamada S, Hirakawa A: Reply to: appropriate statistical descriptions for evaluating the predictive role of epithelial-to-mesenchymal transition in patients with pancreatic cancer Surgery. 2014.05; 155 (5): 959-960.

  5. Hirakawa A, Matsui S.: Response to Letter to the Editor by Drs Wages et al. Statistics in Medicine. 2014.05; 33 (12): 2159-2160.

  6. Taniyama TK, Hashimoto K, Katsumata, N, Hirakawa A, Yonemori K, Yunokawa M,S himizu C,Tamura K, Ando M, Fujiwara Y: Can oncologists predict survival for patients with progressive disease after standard chemotherapies? Current Oncology. 2014.04; 21 (2): 84-90.

  7. Harano K, Hirakawa A, Kato T, Suzuki K, Watanabe S, Katsumata N: Use of colony-stimulating factor in patients with ovarian cancer receiving paclitaxel and carboplatin in Japan Journal Gynecologic Oncology. 2014.04; 25 (2): 124-129.

  8. Ozeki N, Fukui T, Taniguchi T, Usami N, Kawaguchi K, Ito S, Sakao Y, Mitsudomi T, Hirakawa A, Yokoi K: Significance of the serum carcinoembryonic antigen level during the follow-up of patients with completely resected non-small cell lung cancer European Journal of Cardio-Thoracic Surgery. 2014.04; 45 (4): 687-692.

  9. Asakawa T, Hirakawa A, Hamada C.: Bayesian model averaging continual reassessment method for bivariate binary efficacy and toxicity outcomes in phase I oncology trials. Journal of Biopharmaceutical Statistics. 2014.03; 24 (2): 310-325.

  10. Hirakawa A, Yonemori K, Kuwatsuka Y, Kodaira M, Yamamoto H, Yunokawa M, Hamada A, Shimizu C, Tamura K, Gemma A, Fujiwara Y: A descriptive analysis of post-chemotherapy development of interstitial lung disease using spontaneous reporting data in Japan. Current Drug Safety. 2014; 9 (3): 220-226.

  11. Arima H, Wakabayashi T, Nagatani T, Fujii M, Hirakawa A, Murase T, Yambe Y, Yamada T, Yamakawa F, Yamamori I, Yamaguchi M, Oiso Y: Adipsia increases risk of death in patients with central diabetes insipidus Endocrine Journal. 2014; 61 (2): 143-148.

  1. Nakamura S, Fukui T, Taniguchi T, Usami N, Kawaguchi K, Ishiguro F, Hirakawa A, Yokoi K: Prognostic impact of tumor size eliminating the ground glass opacity component: modified clinical T descriptors of the TNM classification of lung cancer Journal of Thoracic Oncology. 2013.12; 8 (12): 1551-1557.

  2. Nakamura R, Atsuta N, Watanabe H, Hirakawa A, Watanabe H, Ito M, Senda J, Katsuno M, Tanaka F, Izumi Y, Morita M, Ogaki K, Taniguchi A, Aiba I, Mizoguchi K, Okamoto K, Hasegawa K, Aoki M, Kawata A, Abe K, Oda M, Konagaya M, Imai T, Nakagawa M, Tsuji S, Kaji R, Nakano I, Sobue G: Neck weakness is a potent prognostic factor in sporadic amyotrophic lateral sclerosis patients Journal of Neurology, Neurosurgery, and Psychiatry. 2013.12; 84 (12): 1365-1371.

  3. Hirano K, Ohgomori T, Kobayashi K, Tanaka F, Matsumoto T, Natori T, Matsuyama Y, Uchimura K, Sakamoto K, Takeuchi H, Hirakawa A, Suzumura A, Sobue G, Ishiguro N, Imagama S, Kadomatsu K: Ablation of keratan sulfate accelerates early phase pathogenesis of ALS PLoS ONE. 2013.06; 25 (8): e66969.

  4. Sato Y, Kawataki M, Hirakawa A, Kato T, Itani T, Hayakawa M: The diameter of the inferior vena cava provides a noninvasive way of calculating central venous pressure in neonates Acta Paediatrica. 2013.06; 102 (6): e241-e246.

  5. Hirakawa A, Hamada C, Matsui S.: A dose-finding approach based on shrunken predictive probability for combinations of two agents in phase I trials. Statistics in Medicine. 2013.05; 32 (26): 4515-4525.

  6. Kobayashi K, Imagama S, Ohgomori T, Hirano K, Uchimura K, Sakamoto K, Hirakawa A, Takeuchi H, Suzumura A, Ishiguro N, Kadomatsu K: Minocycline selectively inhibits M1 polarization of microglia Cell Death & Disease. 2013.03; 7 (4): e525.

  7. Tanabe Y, Hashimoto K, Shimizu C, Hirakawa A, Harano K, Yunokawa M, Yonemori K, Katsumata N, Tamura K, Ando M, Kinoshita T, Fujiwara Y: Paclitaxel-induced peripheral neuropathy in patients receiving adjuvant chemotherapy for breast cancer International Journal of Clinical Oncology. 2013.02; 18 (1): 132-138.

  8. Asano J, Hirakawa A, Hamada C, Yonemori K, Hirata T, Shimizu C, Tamura K, Fujiwara Y: Use of Cox’s cure model to establish clinical determinants of long-term disease-free survival in breast cancer patients treated with neoadjuvant chemotherapy International Journal of Breast Cancer. 2013;

  9. Asano J, Hirakawa A, Hamada C. : A stepwise variable selection for a Cox proportional hazards cure model with application to breast cancer data. Japanese Journal of Biometrics,. 2013; 34 (1): 21-34.

  1. Kaneko S, Hirakawa A, Hamada C.: Gene selection using a high-dimensional regression model with microarrays with cancer prognostic studies. Cancer Informatics. 2012.07; 11 29-39.

  2. Kojima Y, Hashimoto K, Ando M, Hirakawa A, Yonemori K, Kodaira M, Yunokawa M, Shimizu C, Tamura K, Katsumata N, Hosono A, Makimoto A, Fujiwara Y: Clinical outcomes of adult and childhood rhabdomyosarcoma　treated with vincristine, d-actinomycin, and cyclophosphamide chemotherapy Journal of Cancer Research and Clinical Oncology. 2012.07; 138 (7): 1249-1257.

  3. Hirakawa A.: An adaptive dose-finding approach for correlated bivariate binary and continuous outcomes in phase I oncology trials. Statistics in Medicine. 2012.03; 31 (6): 516-532.

  4. Hirakawa A, Hamada C, Yoshimura I.: Sample size calculation through the incorporation of heteroscedasticity and dependence for a penalized t-statistic in microarray experiments. Journal of Biopharmaceutical Statistics. 2012.01; 22 (2): 260-275.

  5. Azuma Y, Hata K, Sai K, Udagawa R, Hirakawa A, Tohkin M, Ryushima Y, Makino Y, Yokote N, Fujiwara Y, Saito Y, Yamamoto H: Significant association between hand-foot syndrome and efficacy of capecitabine in patients with metastatic breast cancer Biological & Pharmaceutical Bulletin. 2012; 35 (5): 717-724.

  6. Hashimoto K, Sasajima Y, Ando M, Yonemori K, Hirakawa A, Furuta K, Tsuda H, Fujiwara Y: Immunohistochemical profile for unknown primary adenocarcinoma PLoS ONE. 2012; 7 (1): e31181.

  7. Yonemori K, Hirakawa A, Ryushima Y, Saito M, Yamamotoro H, Hirata T, Ando M, Kodaira M, Yunokawa M, Shimizu C, Tamura K, Yamamoto H, Fujiwara Y: An analysis of guidance for proper usage documents for oncology drugs in Japan Pharmaceutical Medicine. 2012; 26 165-170.

  8. Yonemori K, Hirakawa A, Ando M, Hirata T, Yunokawa M, Shimizu C, Katsumata N, Tamura K, Yasuhiro F: Content analysis of oncology-related pharmaceutical advertising in a peer-reviewed medical journal PLoS ONE. 2012; 7 (8): e44393.

  1. Hirata T, Yonemori K, Hirakawa A, Shimizu C, Tamura K, Ando M, Katsumata N, Tanimoto M, Fujiwara Y: Efficacy of pleurodesis for malignant pleural effusions in breast cancer patients European Respiratory Journal. 2011.12; 38 (6): 1425-1430.

  2. Hashimoto K, Yonemori K, Katsumata N, Hirakawa A, Hirata T, Yamamoto H, Shimizu C, Tamura K, Ando M, Fujiwara Y: Use of squamous cell carcinoma antigen as biomarker of chemotherapy response in patients with metastatic cervical carcinoma European Journal of Obstetrics & Gynecology and Reproductive Biology. 2011.12; 159 (2): 394-398.

  3. Yonemori K, Tsuta K, Ando M, Hirakawa A, Hatanaka Y, Matsuno Y, Chuman H, Yamazaki N, Fujiwara Y, Hasegawa T: Contrasting prognostic implications of platelet-derived growth factor receptor-beta and vascular endothelial growth factor receptor-2 in patients with angiosarcoma Annals of Surgical Oncology. 2011.10; 18 (10): 2841-2850.

  4. Yonemori K, Hirakawa A, Ando M, Hirata T, Yunokawa M, Shimizu C, Katsumata N, Tamura K, Fujiwara Y: The notorious “drug lag” for oncology in Japan Investigational New Drugs. 2011.08; 29 (4): 706-712.

  5. Hirakawa A, Hamada C, Yoshimura I: Sample size calculation for a regularized t-statistic in microarray experiments. Statistics and Probability Letters. 2011.07; 81 (7): 870-875.

  6. Yonemori K, Hirakawa A, Ando M, Hirata T, Shimizu C, Katsumata N, Tamura K, Fujiwara Y: Compliance with good clinical practice in oncology registration trials in Japan Annals of Oncology. 2011.06; 22 (6): 1451-1456.

  7. Hirata T, Yonemori K, Ando M, Hirakawa A, Tsuda H, Hasegawa T, Chuman H, Namikawa K, Yamazaki N, Fujiwara Y: Efficacy of taxane regimens in patients with metastatic angiosarcoma European Journal of Dermatology. 2011.06; 21 (4): 539-545.

  8. Hashimoto K, Yonemori K, Shimizu C, Hirakawa A, Yamamoto H, Ono M, Hirata T, Kouno T, Tamura K, Katsumata N, Ando M, Fujiwara Y: A retrospective study of the impact of age on patterns of care for elderly patients with metastatic breast cancer Medical Oncology. 2011.06; 28 (2): 434-440.

  9. Yonemori K, Hirakawa A, Ando M, Hirata T, Shimizu C, Katsumata N, Tamura K, Fujiwara Y: Do investigators show selection biases when enrolling patients in phase I oncology registration trials? Journal of Geriatric Oncology. 2011.01; 2 (1): 25-30.

  1. Ando Y, Hirakawa A. : Discussion of “Adaptive and Model-Based Dose-Ranging Trials: Quantitative Evaluation and Recommendations”. Statistics in Biopharmaceutical Research. 2010.11; 2 (4): 462-465.

  2. Hashimoto K, Yonemori K, Katsumata N, Shimizu C, Hirakawa A, Hirata T, Kouno T, Tamura K, Ando M, Fujiwara Y: Prediction of progressive disease using tumor markers in metastatic breast cancer patients without target lesions in first-line chemotherapy Annals of Oncology. 2010.11; 21 (11): 2195-2200.

  3. Yonemori K, Hirakawa A, Komiyama N, Kouno T, Ando M, Fujiwara Y, Urano T, Akagawa H, Maruyama H, Toyoshima S: Participation of elderly patients in registration trials for oncology drug applications in Japan Annals of Oncology. 2010.10; 21 (10): 2112-2118.

  4. Ando Y, Hirakawa A, Uyama Y.: Adaptive clinical trials for new drug applications in Japan. European Neuropsychopharmacology. 2010.10; 21 (2): 175-179.

  5. Yonemori K, Tsuta K, Shimizu C, Hatanaka Y, Hirakawa A, Ono M, Kouno T, Katsumata N, Ando M, Tamura K, Hasegawa T, Kinoshita T, Fujiwara Y: Immunohistochemical expression of HER1, HER3, and HER4 in HER2-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemotherapy Journal of Surgical Oncology. 2010.05; 101 (3): 222-227.

  6. Yonemori K, Kouno T, Ando M, Hirakawa A, Yamamoto H, Ono M, Hirata T, Shimizu C, Tamura K, Katsumata N, Fujiwara Y: Influence of suboptimal treatment in patients with mediastinal primary non-seminomatous germ cell tumor Oncology. 2010; 78 (1): 34-39.

  1. Hirata T, Shimizu C, Yonemori K, Hirakawa A, Kouno T, Tamura K, Ando M, Katsumata N, Fujiwara Y: Change in the hormone receptor status following administration of neoadjuvant chemotherapy and its impact on the long-term outcome in patients with primary breast cancer British Journal of Cancer. 2009.11; 101 (9): 1529-1536.

  2. Yonemori K, Ando M, Yunokawa M, Hirata T, Kouno T, Shimizu C, Tamura K, Katsumata N, Hirakawa A, Matsumoto K, Yamanaka Y, Arioka H, Fujiwara Y: Irinotecan plus carboplatin for patients with carcinoma of unknown primary site British Journal of Cancer. 2009.01; 100 (1): 50-55.

  1. Hirakawa A, Sato Y, Hamada C, Yoshimura I.: A new test statistic based on shrunken sample variance for identifying differentially expressed genes in small microarray experiments. Bioinformatics and Biology Insights. 2008.02; 29 (2): 145-156.

  1. Hirakawa A, Sato Y, Sozu T, Hamada C, Yoshimura I: Estimating the false discovery rate using mixed normal distribution for identifying differentially expressed genes in microarray data analysis. Cancer Informatics. 2007.02; 3 (6): 140-148.

  1. Takahiro Masuda, Koichi Nakazawa, Chieko Mitaka: A case of atypical hemolytic uremic syndrome triggered by a surgery, and treated with eculizumab. J Jpn Soc Intensive Care Med. 2016.11; 23 (6): 673-674.

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