Outline Research Clinical Services & Other Works
Home page URL https://www.tmd.ac.jp/grad/rege/

Staffs

Title Name Researcher information
Professor SEKIYA Ichiro
Assistant Professor KATANO Hisako
Assistant Professor Ozeki Nobutake
Graduate Student KUBOTA Rei
Graduate Student Fujii Shunichi
Graduate Student Kiyotaka Horiuchi
Graduate Student YAGI Misaki
Graduate Student KOMURA Miku
Graduate Student MIURA Yuugo
Graduate Student TANIMOTO Takahiro
Graduate Student FURUOKA Hideto
Graduate Student MATSUTA Seiya
Project Researcher KOMORI Keiichiro
MIZUNO Mitsuru
ENDO Kentaro
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Outline

 Our purpose is to support and advance stem cell research and regenerative medicine for the discovery and development of cures, therapies, diagnostics and research technologies to lieve human suffering from chronic disease and injury.
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Research

1) Development of regenerative medicine with stem cells.
2) Realization and industrialization of the cell and regenerative therapy.
3) Establishment of safety test for regenerative medicine.
4) Translational research.
5) Development of software for 3D analysis of knee MRI.
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Clinical Services & Other Works

 Our mission is to establish a novel treatment for knee osteoarthritis. We have shown that synovial mesenchymal stem cells (MSCs) have a high chondrogenic potential, that transplantation of synovial MSCs accelerates the natural healing process, and that transplantation of synovial MSC can be performed by minimally invasive arthroscopic surgery. After these basic researches and two clinical studies, we started a physician-led clinical trial of autologous synovial MSCs for meniscus injury in August 2017. We concluded a patent license agreement with a company in March 2019 and completed a clinical trial in June 2019. After arranging the issues in the pre-application consultation of the PMDA for regenerative medical products, we are now preparing for the corporate clinical trial as a validation study.

 We also started a clinical study "Intra-articular injection of synovial stem cells for knee osteoarthritis" in December 2017 under the support of the AMED Research Project for Practical Application of Regenerative Medicine (PI: Ichiro Sekiya) to develop a treatment through a new route for synovial stem cells, and completed the observation period for all study subjects in March 2020. We plan to conduct a comparative study to promote this treatment in the near future.

 We further developed MRI 3D analysis software that can automatically display cartilage defects in knee joints. This system was installed in a volume analyzer and released commercially in 2019. It is currently used in medical practices.
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