The Department of Hematology is responsible for clinical services at our University Hospital with treatment of patients with various hematological disorders including leukemias, lymphomas, anemia, and hemorrhagic diseases by chemotherapies, immunotherapies, molecularly-targeted therapies, and hematopoietic cell transplantation. Our department is also responsible for teaching undergraduate students with the lecture course in hematology as well as the clinical clerkship and for training junior and senior residents. Our department is also actively involved, with doctoral course students, in basic and clinical researches aiming to elucidate the molecular and cellular mechanisms involved in pathogenesis of hematological malignancies as well as in acquisition of therapy resistance to develop novel efficient therapies against these diseases.

Our laboratory has been engaged in various research activities, focusing on elucidation of "crosstalk among intracellular signaling pathways, involved in cell proliferation or tumorigenesis of hematopoietic malignancies" as well as "comprehensive mechanisms by which chemotherapeutic agents induce apoptosis in hematopoietic tumors". Based on those accomplishments, we are energetically pursuing new insights, supported by recent drastic advances in molecular biological and genetic analysis methods.
1) New molecular targets in refractory B-cell malignancies and the potential for therapeutic application.
2) Elucidation of the molecular mechanisms involved in formation of drug resistance in acute leukemias with specific oncogenic mutations.
3) Development of novel Chimeric Antigen Receptor (CAR) T cell technologies.
4) Analyses on pathogenesis-related genetic aberrations and their implication to clinical presentation in primary vitreoretinal lymphoma.
5) Analyses on pathogenesis of myeloproliferative neoplasms, mechanisms of drug resistance, and development of effective therapeutic methodologies.
6) Establishment, characterization of novel cell lines derived from hematopoietic tumors and their application in basic research,
7) Development of novel diagnostic methods and management of infectious complications immunocompromised patients.

Department of hematology is responsible for teaching basic and clinical hematology to the 3rd-year medical students in Hematology/Oncology block course. We are also responsible for the 5th- and 6th-year students in clinical clerkship to obtain basic knowledge and problem-solving abilities in hematology as well as general internal medicine. In the clerkship, we focus on the participation in the team, which would be helpful to proceed to the post-graduate training.
Even under the restriction due to COVID-19 pandemic, lectures based on case study and group work are provided.
In the resident training course, we provide training to acquire the basic skills of total health care including communications, diagnosis and treatment of various hematological disorders. Our training is based on the essential issues and skills to obtain the certificate of Hematology Specialist.
We always guide the young doctors, including Ph.D. students, to search for the solutions of their own questions by planning and performing basic and/or clinical studies. Our goal is to raise researchers with an excellent research mind.

As described in 3, our goal is to raise experts with ability to solve problems and provide total health care through learning clinical and basic hematology.

The Department of Hematology provides diagnosis and treatment for hematological diseases, such as leukemia, malignant lymphoma, anemia, and thrombocythemia, with chemotherapeutics, molecularly-targeted drugs, immunosuppressive agents, hematopoietic cell transplantation, and CAR-T cell therapy.

We provide the highest quality of patient care for a wide spectrum of blood diseases and cancers.