疾患モデル動物解析学

156  件  
※ 登録方法の違いにより重複して表示されている場合があります。

  1. Nanae Miyazaki, Shohei Takami, Mami Uemura, Hironobu Oiki, Masataka Takahashi, Hiroshi Kawashima, Yutaka Kanamori, Takako Yoshioka, Mureo Kasahara, Atsuko Nakazawa, Mayumi Higashi, Ayaka Yanagida, Ryuji Hiramatsu, Masami Kanai-Azuma, Jun Fujishiro, Yoshiakira Kanai: Impact of gallbladder hypoplasia on hilar hepatic ducts in biliary atresia. Communications medicine. 2024.06; 4 (1): 111. ( PubMed , DOI )

  2. Masaki Nagaya, Ayuko Uchikura, Kazuaki Nakano, Masahito Watanabe, Hitomi Matsunari, Kazuhiro Umeyama, Naoaki Mizuno, Toshiya Nishimura, Hiromitsu Nakauchi, Hiroshi Nagashima: Generation of insulin-like growth factor 1 receptor-knockout pigs as a potential system for interspecies organogenesis. Regen Ther. 2024.06; 26 783-791. ( PubMed , DOI )

  3. Hisato Nagano, Naoaki Mizuno, Hideyuki Sato, Eiji Mizutani, Ayaka Yanagida, Mayuko Kano, Mariko Kasai, Hiromi Yamamoto, Motoo Watanabe, Fabian Suchy, Hideki Masaki, Hiromitsu Nakauchi: Skin graft with dermis and appendages generated in vivo by cell competition. Nature Communications. 2024.04; 15 (1): 3366. ( PubMed , DOI )

  1. Ito M, Ito H, Miyoshi K, Kanai-Azuma M: Chronic non-discriminatory social defeat stress during the perinatal period induces depressive-like outcomes in female mice. Brain Research. 2023.12; 1825 148734. ( PubMed , DOI )

  2. Maruyama N, Fukunaga I, Kogo T, Endo T, Fujii W, Kanai-Azuma M, Naito K, Sugiura K: Accumulation of senescent cells in the stroma of aged mouse ovary. J Reprod Dev. 2023.12; 69 (6): 328-336. ( PubMed , DOI )

  3. Melig G, Nobuhisa I, Saito K, Tsukahara R, Itabashi A, Kanai Y, Kanai-Azuma M, Osawa M, Oshima M, Iwama A, Taga T: A Sox17 downstream gene Rasip1 is involved in the hematopoietic activity of intra-aortic hematopoietic clusters in the midgestation mouse embryo. Inflamm Regen. 2023.08; 43 (1): 41. ( PubMed , DOI )

  4. Mayuko Kano, Naoaki Mizuno, Hideyuki Sato, Takaharu Kimura, Rei Hirochika, Yasumasa Iwasaki, Naoko Inoshita, Hisato Nagano, Mariko Kasai, Hiromi Yamamoto, Tomoyuki Yamaguchi, Hidetaka Suga, Hideki Masaki, Eiji Mizutani, Hiromitsu Nakauchi: Functional calcium-responsive parathyroid glands generated using single-step blastocyst complementation. Proc Natl Acad Sci U S A. 2023.07; 120 (28): e2216564120. ( PubMed , DOI )

  5. Yomogita H, Ito H, Hashimoto K, Kudo A, Fukushima T, Endo T, Hirate Y, Akimoto Y, Komada M, Kanai Y, Miyasaka N, Kanai-Azuma M: A possible function of Nik-related kinase in the labyrinth layer of delayed delivery mouse placentas. J Reprod Dev. 2023.02; 69 (1): 32-40. ( PubMed , DOI )

  1. Uchida A, Imaimatsu K, Suzuki H, Han X, Ushioda H, Uemura M, Imura-Kishi K, Hiramatsu R, Takase HM, Hirate Y, Ogura A, Kanai-Azuma M, Kudo A, Kanai Y: SOX17-positive rete testis epithelium is required for Sertoli valve formation and normal spermiogenesis in the male mouse. Nature communications. 2022.12; 13 (1): 7860. ( PubMed , DOI )

  2. Yomogita H, Miyasaka N, Kanai-Azuma M: A Review of Delayed Delivery Models and the Analysis Method in Mice. Journal of developmental biology. 2022.05; 10 (2): ( PubMed , DOI )

  3. Mami Oikawa, Hisato Kobayashi, Makoto Sanbo, Naoaki Mizuno, Kenyu Iwatsuki, Tomoya Takashima, Keiko Yamauchi, Fumika Yoshida, Takuya Yamamoto, Takashi Shinohara, Hiromitsu Nakauchi, Kazuki Kurimoto, Masumi Hirabayashi, Toshihiro Kobayashi: Functional primordial germ cell-like cells from pluripotent stem cells in rats. Science. 2022.04; 376 (6589): 176-179. ( PubMed , DOI )

  4. Mami Oikawa, Mayuko Nagae, Naoaki Mizuno, Kenyu Iwatsuki, Fumika Yoshida, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura, Hiromitsu Nakauchi, Masumi Hirabayashi, Toshihiro Kobayashi: Generation of Tfap2c-T2A-tdTomato knock-in reporter rats via adeno-associated virus-mediated efficient gene targeting. Mol Reprod Dev. 2022.03; 89 (3): 129-132. ( PubMed , DOI )

  5. Kazuto Yamazaki, Kenji Kubara, Satoko Ishii, Peng Li, Ryo Dairiki, Taro Hihara, Yuta Ishizuka, Yukina Izumi, Minoru Kumai, Tsutomu Kamisako, Hiroyoshi Ishizaki, Hideyuki Sato, Hideki Masaki, Naoaki Mizuno, Kaoru Mitsuhashi, Masashi Ito, Sanae Hamanaka, Tomoyuki Yamaguchi, Motoo Watanabe, Fumihiro Sugiyama, Hiromitsu Nakauchi: In vitro and in vivo functions of T cells produced in complemented thymi of chimeric mice generated by blastocyst complementation. Sci Rep. 2022.02; 12 (1): 3242. ( PubMed , DOI )

  1. Ryuichi Yamada, Akira Oguri, Katsunori Fujiki, Katsuhiko Shirahige, Yoshikazu Hirate, Masami Kanai-Azuma, Hirotaka Takezoe, Yoshihiro Akimoto, Naoki Takahashi, Yoshiakira Kanai: MAB21L1 modulates gene expression and DNA metabolic processes in the lens placode. Dis Model Mech. 2021.12; 14 (12): ( PubMed , DOI )

  2. Toshihiro Kobayashi, Aracely Castillo-Venzor, Chris A Penfold, Michael Morgan, Naoaki Mizuno, Walfred W C Tang, Yasuyuki Osada, Masao Hirao, Fumika Yoshida, Hideyuki Sato, Hiromitsu Nakauchi, Masumi Hirabayashi, M Azim Surani: Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells. Cell Rep. 2021.10; 37 (2): 109812. ( PubMed , DOI )

  3. Hirate Yoshikazu, Hayakawa Kana, Nakano Yuki, Kumazawa Shiori, Miura Kento, Kanai Yoshiakira, Kanai-Azuma Masami: Role of SOX17 in crypt formation and regulation of SOX9 and AREG expression at the implantation site(和訳中) Experimental Animals. 2021.06; 70 (Suppl.): S61. ( 医中誌 )

  4. Okiko Habara, Catriona Y Logan, Masami Kanai-Azuma, Roeland Nusse, Hinako M Takase: WNT signaling in pre-granulosa cells is required for ovarian folliculogenesis and female fertility. Development. 2021.05; 148 (9): ( PubMed , DOI )

  5. Yoshikazu Hirate, Kana Hayakawa, Yuki Nakano, Shiori Kumazawa, Kento Miura, Yoshiakira Kanai, Masami Kanai-Azuma: Early Crypt Formation Defects in the Uterine Epithelia of Sox17 Heterozygous Mice. Sex Dev. 2021.03; 14 (1-6): 40-50. ( PubMed , DOI )

  6. Naito Yoichi, Aburatani Hiroyuki, Amano Toraji, Baba Eishi, Furukawa Toru, Hayashida Tetsu, Hiyama Eiso, Ikeda Sadakatsu, Kanai Masashi, Kato Motohiro, Kinoshita Ichiro, Kiyota Naomi, Kohno Takashi, Kohsaka Shinji, Komine Keigo, Matsumura Itaru, Miura Yuji, Nakamura Yoshiaki, Natsume Atsushi, Nishio Kazuto, Oda Katsutoshi, Oda Naoyuki, Okita Natsuko, Oseto Kumiko, Sunami Kuniko, Takahashi Hideaki, Takeda Masayuki, Tashiro Shimon, Toyooka Shinichi, Ueno Hideki, Yachida Shinichi, Yoshino Takayuki, Tsuchihara Katsuya: Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (edition 2.1) INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY. 2021.02; 26 (2): 233-283. ( PubMed , DOI )

  7. Tadashi Shin, Yuichi Hiraoka, Tokiwa Yamasaki, Jamey D Marth, Josef M Penninger, Masami Kanai-Azuma, Kohichi Tanaka, Satoshi Kofuji, Hiroshi Nishina: MKK7 deficiency in mature neurons impairs parental behavior in mice. Genes Cells. 2021.01; 26 (1): 5-17. ( PubMed , DOI )

  8. Kasane Imura-Kishi, Aya Uchida, Naoki Tsunekawa, Hitomi Suzuki, Hinako M Takase, Yoshikazu Hirate, Masami Kanai-Azuma, Ryuji Hiramatsu, Masamichi Kurohmaru, Yoshiakira Kanai: Low retinoic acid levels mediate regionalization of the Sertoli valve in the terminal segment of mouse seminiferous tubules. Sci Rep. 2021.01; 11 (1): 1110. ( PubMed , DOI )

  1. Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Terao C, Amariuta T, Gazal S, Kochi Y, Horikoshi M, Suzuki K, Ito K, Koyama S, Ozaki K, Niida S, Sakata Y, Sakata Y, Kohno T, Shiraishi K, Momozawa Y, Hirata M, Matsuda K, Ikeda M, Iwata N, Ikegawa S, Kou I, Tanaka T, Nakagawa H, Suzuki A, Hirota T, Tamari M, Chayama K, Miki D, Mori M, Nagayama S, Daigo Y, Miki Y, Katagiri T, Ogawa O, Obara W, Ito H, Yoshida T, Imoto I, Takahashi T, Tanikawa C, Suzuki T, Sinozaki N, Minami S, Yamaguchi H, Asai S, Takahashi Y, Yamaji K, Takahashi K, Fujioka T, Takata R, Yanai H, Masumoto A, Koretsune Y, Kutsumi H, Higashiyama M, Murayama S, Minegishi N, Suzuki K, Tanno K, Shimizu A, Yamaji T, Iwasaki M, Sawada N, Uemura H, Tanaka K, Naito M, Sasaki M, Wakai K, Tsugane S, Yamamoto M, Yamamoto K, Murakami Y, Nakamura Y, Raychaudhuri S, Inazawa J, Yamauchi T, Kadowaki T, Kubo M, Kamatani Y: Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases. Nature genetics. 2020.07; 52 (7): 669-679. ( PubMed , DOI )

  2. Pattarapanawan M, Uemura M, Miyazaki N, Takami S, Tomiyasu H, Tsunekawa N, Hirate Y, Fujishiro J, Kurohmaru M, Kanai-Azuma M, Higashiyama H, Kanai Y: Anatomical and histological characteristics of the hepatobiliary system in adult Sox17 heterozygote mice. Anatomical record (Hoboken, N.J. : 2007). 2020.06; 303 (12): 3096-3107. ( PubMed , DOI )

  3. Mami Uemura, Mayumi Higashi, Montri Pattarapanawan, Shohei Takami, Naoki Ichikawa, Hiroki Higashiyama, Taizo Furukawa, Jun Fujishiro, Yuki Fukumura, Takashi Yao, Tatsuro Tajiri, Masami Kanai-Azuma, Yoshiakira Kanai: Gallbladder wall abnormality in biliary atresia of mouse Sox17 +/- neonates and human infants Dis Model Mech. 2020.04; 13 (4): ( PubMed , DOI )

  4. Yamada, T, Takechi M (Co-first), Yokoyama N, Hiraoka Y, Ishikubo H, Usami T, Furutera T, Taga Y, Hirate Y, Kanai-Azuma M, Yoda T, Ogawa-Goto K, Iseki S: Heterozygous mutation of the splicing factor Sf3b4 affects development of the axial skeleton and forebrain in mouse. Developmental Dynamics. 2020.01; ( PubMed , DOI )

  1. Arata Honda, Ryoma Tachibana, Kazuya Hamada, Kohtaro Morita, Naoaki Mizuno, Kento Morita, Masahide Asano: Efficient derivation of knock-out and knock-in rats using embryos obtained by in vitro fertilization. Sci Rep. 2019.08; 9 (1): 11571. ( PubMed , DOI )

  2. Rie Saba, Keiko Kitajima, Lucille Rainbow, Silvia Engert, Mami Uemura, Hidekazu Ishida, Ioannis Kokkinopoulos, Yasunori Shintani, Shigeru Miyagawa, Yoshiakira Kanai, Masami Kanai-Azuma, Peter Koopman, Chikara Meno, John Kenny, Heiko Lickert, Yumiko Saga, Ken Suzuki, Yoshiki Sawa, Kenta Yashiro: Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice. Sci Rep. 2019.08; 9 (1): 11953. ( PubMed , DOI )

  3. Hirate Yoshikazu, Nakano Yuki, Yoshida Tatsumi, Ito Hikaru, Uemura Mami, Kanai Yoshiakira, Kanai-Azuma Masami: 子宮内膜上皮移植に対する、TRECKに基づいたアプローチ法の確立(Establishment of a TRECK-based approach for replacement of uterine endometrial epithelium) Experimental Animals. 2019.07; 68 (Suppl.): S66. ( 医中誌 )

  4. Naoaki Mizuno, Eiji Mizutani, Hideyuki Sato, Mariko Kasai, Hiromitsu Nakauchi, Tomoyuki Yamaguchi: CRISPR/Cas9 + AAV-mediated Intra-embryonic Gene Knocking in Mice. Bio Protoc. 2019.07; 9 (13): e3295. ( PubMed , DOI )

  5. Sakurai Atsushi, Kinoshita Kosaku, Maeda Yukihiro, Homma Yosuke, Tahara Yoshio, Yonemoto Naohiro, Nagao Ken, Yaguchi Arino, Morimura Naoto, Inokuchi Sadaki, Masui Yoshihiro, Miura Kunihisa, Tsutsumi Haruhiko, Takuma Kiyotsugu, Atsushi Ishihara, Nakano Minoru, Tanaka Hiroshi, Ikegami Keiichi, Arai Takao, Yaguchi Arino, Kitamura Nobuya, Oda Shigeto, Kobayashi Kenji, Suda Takayuki, Ono Kazuyuki, Morimura Naoto, Furuya Ryosuke, Furuya Ryosuke, Koido Yuichi, Iwase Fumiaki, Nagao Ken, Kanesaka Shigeru, Okada Yasusei, Unemoto Kyoko, Sadahiro Tomohito, Iyanaga Masayuki, Muraoka Asaki, Hayashi Munehiro, Ishimatsu Shinichi, Miyake Yasufumi, Yokokawa Hideo, Koyama Yasuaki, Tsuchiya Asuka, Kashiyama Tetsuya, Hayashi Munetaka, Oshima Kiyohiro, Kiyota Kazuya, Hamabe Yuichi, Yokota Hiroyuki, Hori Shingo, Inaba Shin, Sakamoto Tetsuya, Harada Naoshige, Kimura Akio, Kanai Masayuki, Otomo Yasuhiro, Sugita Manabu, Kinoshita Kosaku, Sakurai Takatoshi, Kitano Mitsuhide, Matsuda Kiyoshi, Tanaka Kotaro, Yoshihara Katsunori, Yoh Kikuo, Suzuki Junichi, Toyoda Hiroshi, Mashiko Kunihiro, Shimizu Naoki, Muguruma Takashi, Shimada Tadanaga, Kobe Yoshiro, Shoko Tomohisa, Nakanishi Kazuya, Shiga Takashi, Yamamoto Takefumi, Sekine Kazuhiko, Izuka Shinichi: Confirmed cardiac output on emergency medical services arrival as confounding by indication: an observational study of prehospital airway management in patients with out-of-hospital cardiac arrest EMERGENCY MEDICINE JOURNAL. 2019.07; 36 (7): 410-+. ( DOI )

  6. Takahashi Hitomi, Hirate Yoshikazu, Li Jinling, Ito Yoshiaki, Otsuka Chiho, Anezaki Mayumi, Asahara Hirosh, Chen-Tsai Ruby Yanru, Kanai-Azuma Masami: 試験管内授精マウス胚におけるTARGATTノックインシステムを用いた部位特異的遺伝子導入(Site-specific transgenesis using TARGATT knock-in system in in vitro fertilized mouse embryos) Experimental Animals. 2019.07; 68 (Suppl.): S219. ( 医中誌 )

  7. Risa Nomura, Kenichi Kashimada, Hitomi Suzuki, Liang Zhao, Atsumi Tsuji-Hosokawa, Hideo Yagita, Masatoshi Takagi, Yoshiakira Kanai, Josephine Bowles, Peter Koopman, Masami Kanai-Azuma, Tomohiro Morio: Nr5a1 suppression during the murine fetal period optimizes ovarian development by fine-tuning Notch signaling. J. Cell. Sci.. 2019.04; 132 (8): ( PubMed , DOI )

  8. Tamura Tomoyoshi, Suzuki Masaru, Hayashida Kei, Sasaki Junichi, Yonemoto Naohiro, Sakurai Atsushi, Tahara Yoshio, Nagao Ken, Yaguchi Arino, Morimura Naoto, Inokuchi Sadaki, Masui Yoshihiro, Miura Kunihisa, Tsutsumi Haruhiko, Takuma Kiyotsugu, Atsushi Ishihara, Nakano Minoru, Tanaka Hiroshi, Ikegami Keiichi, Arai Takao, Yaguchi Arino, Kitamura Nobuya, Oda Shigeto, Kobayashi Kenji, Suda Takayuki, Ono Kazuyuki, Morimura Naoto, Furuya Ryosuke, Koido Yuichi, Iwase Fumiaki, Nagao Ken, Kanesaka Shigeru, Okada Yasusei, Unemoto Kyoko, Sada-hiro Tomohito, Iyanaga Masayuki, Muraoka Asaki, Hayashi Munehiro, Ishimatsu Shinichi, Miyake Yasufumi, Yokokawa Hideo, Koyama Yasuaki, Tsuchiya Asuka, Kashiyama Tetsuya, Hayashi Munetaka, Oshima Kiyohiro, Kiyota Kazuya, Hamabe Yuichi, Yokota Hiroyuki, Hori Shingo, Inaba Shin, Sakamoto Tetsuya, Harada Naoshige, Kimura Akio, Kanai Masayuki, Otomo Yasuhiro, Sugita Manabu, Kinoshita Kosaku, Sakurai Takatoshi, Kitano Mitsuhide, Matsuda Kiyoshi, Tanaka Kotaro, Yoshihara Katsunori, Yoh Kikuo, Suzuki Junichi, Toyoda Hiroshi, Mashiko Kunihiro, Shimizu Naoki, Muguruma Takashi, Shimada Tadanaga, Kobe Yoshiro, Shoko Tomohisa, Nakanishi Kazuya, Shiga Takashi, Yamamoto Takefumi, Sekine Kazuhiko, Izuka Shinichi: Renal Function and Outcome of Out-of-Hospital Cardiac Arrest - Multicenter Prospective Study (SOS-KANTO 2012 Study) - CIRCULATION JOURNAL. 2019.01; 83 (1): 139-+. ( DOI )

  9. Miura K, Harikae K, Nakaguch M, Imaimatsu K, Hiramatsu R, Tomita A, Hirate Y, Kanai-Azuma M, Kurohmaru M, Ogura A, Kanai Y: Molecular and genetic characterization of partial masculinization in embryonic ovaries grafted into male nude mice. PLoS ONE. 2019; 14 (3): e0212367. ( PubMed , DOI )

  1. Miyake H, Yamada S, Fujii Y, Sawai H, Arimori N, Yamanouchi Y, Ozasa Y, Kanai M, Sago H, Sekizawa A, Takada F, Masuzaki H, Matsubara Y, Hirahara F, Kugu K: Correction: Nationwide survey for current clinical status of amniocentesis and maternal serum marker test in Japan. Journal of human genetics. 2018.11; 63 (11): 1195. ( PubMed , DOI )

  2. Naoaki Mizuno, Eiji Mizutani, Hideyuki Sato, Mariko Kasai, Aki Ogawa, Fabian Suchy, Tomoyuki Yamaguchi, Hiromitsu Nakauchi: Intra-embryo Gene Cassette Knockin by CRISPR/Cas9-Mediated Genome Editing with Adeno-Associated Viral Vector. iScience. 2018.11; 9 286-297. ( PubMed , DOI )

  3. Sanae Hamanaka, Ayumi Umino, Hideyuki Sato, Tomonari Hayama, Ayaka Yanagida, Naoaki Mizuno, Toshihiro Kobayashi, Mariko Kasai, Fabian Patrik Suchy, Satoshi Yamazaki, Hideki Masaki, Tomoyuki Yamaguchi, Hiromitsu Nakauchi: Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation. Stem Cell Reports. 2018.10; 11 (4): 988-997. ( PubMed , DOI )

  4. Tomoyuki Yamaguchi, Hideyuki Sato, Toshihiro Kobayashi, Megumi Kato-Itoh, Teppei Goto, Hiromasa Hara, Naoaki Mizuno, Ayaka Yanagida, Ayumi Umino, Sanae Hamanaka, Fabian Suchy, Hideki Masaki, Yasunori Ota, Masumi Hirabayashi, Hiromitsu Nakauchi: An interspecies barrier to tetraploid complementation and chimera formation. Sci Rep. 2018.10; 8 (1): 15289. ( PubMed , DOI )

  5. Igarashi H, Uemura M, Hiramatsu R, Hiramatsu R, Segami S, Pattarapanawan M, Hirate Y, Yoshimura Y, Hashimoto H, Higashiyama H, Sumitomo H, Kurohmaru M, Saijoh Y, Suemizu H, Kanai-Azuma M, Kanai Y: Sox17 is essential for proper formation of the marginal zone of extraembryonic endoderm adjacent to a developing mouse placental disk. Biol. Reprod. 2018.09; 99 (3): 578-589. ( PubMed , DOI )

  6. Yoshimura T, Watanabe T, Kuramochi-Miyagawa S, Takemoto N, Shiromoto Y, Kudo A, Kanai-Azuma M, Tashiro F, Miyazaki S, Katanaya A, Chuma S, Miyazaki J: Mouse GTSF1 is an essential factor for secondary piRNA biogenesis. EMBO Rep. 2018.04; 19 (4): e42054. ( PubMed , DOI )

  7. Saito K, Nobuhisa I, Harada K, Takahashi S, Anani M, Lickert H, Kanai-Azuma M, Kanai Y, Taga T: Maintenance of hematopoietic stem and progenitor cells in fetal intra-aortic hematopoietic clusters by the Sox17-Notch1-Hes1 axis. Exp. Cell Res. 2018.04; 365 (1): 145-155. ( PubMed , DOI )

  8. Hirata J, Hirota T, Ozeki T, Kanai M, Sudo T, Tanaka T, Hizawa N, Nakagawa H, Sato S, Mushiroda T, Saeki H, Tamari M, Okada Y.: Variants at HLA-A, HLA-C, and HLA-DQB1 Confer Risk of Psoriasis Vulgaris in Japanese. J Invest Dermatol. 2018.03; 138 (3): 542-548. ( DOI )

  9. Higashiyama H, Uemura M, Igarashi H, Kurohmaru M, Kanai-Azuma M and Kanai Y: Anatomy and development of the extrahepatic biliary system in mouse and rat: a perspective on the evolutionary loss of the gallbladder. J. Anat. 2018.01; 232 (1): 134-145. ( PubMed , DOI )

  10. Takase MH, Kanai-Azuma M, Kanai Y: Differentiation of ovaries. Reference Module in Biomedical Sciences. 2018;

  1. Shinozaki Koichiro, Suzuki Masaru, Oda Shigeto, Becker Lance B., Tagami Takashi, Sakurai Atsushi, Tahara Yoshio, Nagao Ken, Yonemoto Naohiro, Yaguchi Arino, Morimura Naoto, Miyazaki Dai, Ogasawara Tomoko, Hayashida Kei, Amino Mari, Nomura Tomohisa, Akashi Akiko, Inokuchi Sadaki, Masui Yoshihiro, Miura Kunihisa, Tsutsumi Haruhiko, Takuma Kiyotsugu, Atsushi Ishihara, Nakano Minoru, Tanaka Hiroshi, Ikegami Keiichi, Arai Takao, Yaguchi Arino, Kitamura Nobuya, Kobayashi Kenji, Suda Takayuki, Ono Kazuyuki, Morimura Naoto, Furuya Ryosuke, Koido Yuichi, Iwase Fumiaki, Kanesaka Shigeru, Okada Yasusei, Unemoto Kyoko, Sadahiro Tomohito, Iyanaga Masayuki, Muraoka Asaki, Hayashi Munehiro, Ishimatsu Shinichi, Miyake Yasufumi, Yokokawa Hideo, Koyama Yasuaki, Tsuchiya Asuka, Kashiyama Tetsuya, Hayashi Munetaka, Oshima Kiyohiro, Kiyota Kazuya, Hamabe Yuichi, Yokota Hiroyuki, Hori Shingo, Inaba Shin, Sakamoto Tetsuya, Harada Naoshige, Kimura Akio, Kanai Masayuki, Otomo Yasuhiro, Sugita Manabu, Kinoshita Kosaku, Sakurai Takatoshi, Kitano Mitsuhide, Matsuda Kiyoshi, Tanaka Kotaro, Yoshihara Katsunori, Yoh Kikuo, Suzuki Junichi, Toyoda Hiroshi, Mashiko Kunihiro, Shimizu Naoki, Muguruma Takashi, Shimada Tadanaga, Kobe Yoshiro, Shoko Tomohisa, Nakanishi Kazuya, Shiga Takashi, Yamamoto Takefumi, Sekine Kazuhiko, Izuka Shinichi: Initial Blood Ammonia Level Is a Useful Prognostication Tool in Out-of-Hospital Cardiac Arrest - Multicenter Prospective Study (SOS-KANTO 2012 Study) CIRCULATION JOURNAL. 2017.12; 81 (12): 1839-+. ( DOI )

  2. Akashi Akiko, Kashiura Masahiro, Sugiyama Kazuhiro, Hamabe Yuichi, Sakurai Atsushi, Tahara Yoshio, Yonemoto Naohiro, Nagao Ken, Yaguchi Arino, Morimura Naoto, Takashi Tagami, Miyazaki Dai, Ogasawara Tomoko, Hayashida Kei, Suzuki Masaru, Amino Mari, Kitamura Nobuya, Nomura Tomohisa, Shimizu Naoki, Inokuchi Sadaki, Masui Yoshihiro, Miura Kunihisa, Tsutsumi Haruhiko, Takuma Kiyotsugu, Atsushi Ishihara, Nakano Minoru, Tanaka Hiroshi, Ikegami Keiichi, Arai Takao, Oda Shigeto, Kobayashi Kenji, Suda Takayuki, Ono Kazuyuki, Furuya Ryosuke, Koido Yuichi, Iwase Fumiaki, Kanesaka Shigeru, Okada Yasusei, Unemoto Kyoko, Sadahiro Tomohito, Iyanaga Masayuki, Muraoka Asaki, Hayashi Munehiro, Ishimatsu Shinichi, Miyake Yasufumi, Yokokawa Hideo, Koyama Yasuaki, Tsuchiya Asuka, Kashiyama Tetsuya, Hayashi Munetaka, Oshima Kiyohiro, Kiyota Kazuya, Yokota Hiroyuki, Hori Shingo, Inaba Shin, Sakamoto Tetsuya, Harada Naoshige, Kimura Akio, Kanai Masayuki, Otomo Yasuhiro, Sugita Manabu, Kinoshita Kosaku, Sakurai Takatoshi, Kitano Mitsuhide, Matsuda Kiyoshi, Tanaka Kotaro, Yoshihara Katsunori, Yoh Kikuo, Suzuki Junichi, Toyoda Hiroshi, Mashiko Kunihiro, Shimizu Naoki, Muguruma Takashi, Shimada Tadanaga, Kobe Yoshiro, Shoko Tomohisa, Nakanishi Kazuya, Shiga Takashi, Yamamoto Takefumi, Sekine Kazuhiko, Izuka Shinichi: A NEW RULE FOR TERMINATING RESUSCITATION OF OUT-OF-HOSPITAL CARDIAC ARREST PATIENTS IN JAPAN: A PROSPECTIVE STUDY JOURNAL OF EMERGENCY MEDICINE. 2017.09; 53 (3): 345-352. ( DOI )

  3. Kishi K, Uchida A, Takase HM, Suzuki H, Kurohmaru M, Tsunekawa N, Kanai-Azuma M, Stephen A. Wood and Kanai Y: Spermatogonial deubiquitinase USP9X is essential for proper spermatogenesis in mice. Reproduction. 2017.08; 154 (2): 135-143. ( PubMed , DOI )

  4. Hirate Yoshikazu, Hayakawa Kana, Toyomura Yuga, Igarashi Hitomi, Miura Kento, Kanai Yoshiakira, Kanai-Azuma Masami: Sox17ハプロ不全による着床異常マウスにおける子宮上皮遺伝子の発現変化(Expression changes in uterine epithelial genes in implantation-defective mice due to Sox17 haploinsufficiency) Experimental Animals. 2017.06; 66 (Suppl.): S101. ( 医中誌 )

  5. Ohgaki R, Ohmori T, Hara S,Nakagomi S, Kanai-Azuma M, Kaneda-Nakashima K, Okuda S, Nagamori S, Kanai Y: Essential Roles of L-Type Amino Acid Transporter 1 in Syncytiotrophoblast Development by Presenting Fusogenic 4F2hc. Mol. Cell. Biol. 2017.06; 37 (11): ( PubMed , DOI )

  6. Miura K, Murata C, Harikae K, Suzuki H, Kanai-Azuma M, Kurohmaru M, Tsunekawa N, Kanai Y: Defects in the first wave of folliculogenesis in mouse XO ovaries. J. Reprod. Dev. 2017.06; 63 (3): 333-338. ( PubMed , DOI )

  7. Higashiyama H, Ozawa A, Sumitomo H, Uemura M, Fujino K, Igarashi H, Imaimatsu K, Tsunekawa N, Hirate Y, Kurohmaru M, Saijoh Y, Kanai-Azuma M and Kanai Y: Embryonic cholecystitis and defective gallbladder contraction in the Sox17-haploinsufficient mouse model of biliary atresia. Development. 2017.05; 144 (10): 1906-1917. ( PubMed , DOI )

  8. Yusuke Watanabe, Kota Y Miyasaka, Atsushi Kubo, Yasuyuki S Kida, Osamu Nakagawa, Yoshikazu Hirate, Hiroshi Sasaki, Toshihiko Ogura: Notch and Hippo signaling converge on Strawberry Notch 1 (Sbno1) to synergistically activate Cdx2 during specification of the trophectoderm. Scientific Reports. 2017.04; 7 46135. ( PubMed , DOI )

  9. Tomoyuki Yamaguchi, Hideyuki Sato, Megumi Kato-Itoh, Teppei Goto, Hiromasa Hara, Makoto Sanbo, Naoaki Mizuno, Toshihiro Kobayashi, Ayaka Yanagida, Ayumi Umino, Yasunori Ota, Sanae Hamanaka, Hideki Masaki, Sheikh Tamir Rashid, Masumi Hirabayashi, Hiromitsu Nakauchi: Interspecies organogenesis generates autologous functional islets. Nature. 2017.02; 542 (7640): 191-196. ( PubMed , DOI )

  1. Ayaka Yanagida, Naoak Mizuno, Yuji Yamazaki, Megumi Kato-Itoh, Ayumi Umino, Hideyuki Sato, Keiichi Ito, Tomoyuki Yamaguchi, Hiromitsu Nakauchi, Akihide Kamiya: Investigation of bipotent differentiation of hepatoblasts using inducible diphtheria toxin receptor-transgenic mice. Hepatol Res. 2016.07; 46 (8): 816-828. ( PubMed , DOI )

  2. Hayama T, Yamaguchi T, Kato-Itoh M, Ishii Y, Mizuno N, Umino A, Sato H, Sanbo M, Hamanaka S, Masaki H, Hirabayashi M, Nakauchi H.: Practical selection methods for rat and mouse round spermatids without DNA staining by flow cytometric cell sorting. Mol Reprod Dev.. 2016.06;

  3. Uchida A, Kishi K, Aiyama Y, Miura K, Takase HM, Suzuki H, Kanai-Azuma M, Iwamori T, Kurohmaru M, Tsunekawa N, Kanai Y: In vivo dynamics of GFRalpha1-positive spermatogonia stimulated by GDNF signals using a bead transplantation assay. Biochem Biophys Res Commun. 2016.05; ( PubMed , DOI )

  4. Hirate Y, Suzuki H, Kawasumi M, Takase HM, Igarashi H, Naquet P, Kanai Y, Kanai-Azuma M: Mouse Sox17 haploinsufficiency leads to female subfertility due to impaired implantation. Sci Rep. 2016.04; 6 24171. ( PubMed , DOI )

  1. Hirate Y, Hirahara S, Inoue K, Kiyonari H, Niwa H, Sasaki H.: Par-aPKC-dependent and -independent mechanisms cooperatively control cell polarity, Hippo signaling, and cell positioning in 16-cell stage mouse embryos. Development, Growth & Differentiation. 2015.10; 57 (8): 544-556. ( PubMed , DOI )

  2. Aiyama Y, Tsunekawa N, Kishi K, Kawasumi M, Suzuki H, Kanai-Azuma M, Kurohmaru M, Kanai Y: A Niche for GFRalpha1-Positive Spermatogonia in the Terminal Segments of the Seminiferous Tubules in Hamster Testes. Stem Cells. 2015.09; 33 (9): 2811-2824. ( PubMed , DOI )

  3. Suzuki H, Kanai-Azuma M, Kanai Y: From Sex Determination to Initial Folliculogenesis in Mammalian Ovaries: Morphogenetic Waves along the Anteroposterior and Dorsoventral Axes. Sex Dev. 2015.09; 9 (4): 190-204. ( PubMed , DOI )

  4. Uemura M, Igarashi H, Ozawa A, Tsunekawa N, Kurohmaru M, Kanai-Azuma M, Kanai Y: Fate mapping of gallbladder progenitors in posteroventral foregut endoderm of mouse early somite-stage embryos. J. Vet. Med. Sci. 2015.05; 77 (5): 587-591. ( PubMed , DOI )

  1. Shinomura M, Kishi K, Tomita A, Kawasumi M, Kanezashi H, Kuroda Y, Tsunekawa N, Ozawa A, Aiyama Y, Yoneda A, Suzuki H, Saito M, Picard JY, Kohno K, Kurohmaru M, Kanai-Azuma M, Kanai Y: A novel Amh-Treck transgenic mouse line allows toxin-dependent loss of supporting cells in gonads. Reproduction. 2014.12; 148 (6): H1-H9. ( PubMed , DOI )

  2. Takahashi S, Lee J, Kohda T, Matsuzawa A, Kawasumi M, Kanai-Azuma M, Kaneko-Ishino T and Ishino F: Induction of the G2/M transition stabilizes haploid embryonic stem cells. Development. 2014.10; 141 (20): 3842-3847. ( PubMed , DOI )

  3. Wicklow E, Blij S, Frum T, Hirate Y, Lang RA, Sasaki H, Ralston A.: HIPPO pathway members restrict SOX2 to the inner cell mass where it promotes ICM fates in the mouse blastocyst. PLOS Genetics. 2014.10; 10 (10): e1004618. ( PubMed , DOI )

  4. Tomonari Hayama, Tomoyuki Yamaguchi, Megumi Kato-Itoh, Sanae Hamanaka, Mami Kawarai, Makoto Sanbo, Chihiro Tamura, Youn-Su Lee, Ayaka Yanagida, Hideyuki Murayama, Naoaki Mizuno, Ayumi Umino, Hideyuki Sato, Satoshi Yamazaki, Hideki Masaki, Toshihiro Kobayashi, Masumi Hirabayashi, Hiromitsu Nakauchi: Generation of mouse functional oocytes in rat by xeno-ectopic transplantation of primordial germ cells. Biol Reprod. 2014.10; 91 (4): 89. ( PubMed , DOI )

  5. Ryota Inokuchi, Kensuke Nakamura, Naoaki Mizuno, Hajime Sato, Kazuaki Shinohara, Takehiro Matsubara, Kent Doi, Takeshi Ishii, Masataka Gunshin, Susumu Nakajima, Naoki Yahagi: Adult-onset seizures in a patient with Down syndrome and portosystemic shunt. Brain Dev. 2014.08; 36 (7): 626-629. ( PubMed , DOI )

  6. Nobuhisa Ikuo, Osawa Mitsujiro, Uemura Mami, Kishikawa Yoko, Anani Maha, Harada Kaho, Takagi Haruna, Saito Kiyoka, Kanai-Azuma Masami, Kanai Yoshiakira, Iwama Atsushi, Taga Tetsuya: Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters. Mol Cell Biol. 2014.06; 34 (11): 1976-1990. ( PubMed , DOI )

  7. Mishima T, Fujiwara T, Sanada M, Kofuji T, Kanai-Azuma M, Akagawa K: Syntaxin 1B, but not syntaxin 1A, is necessary for the regulation of synaptic vesicle exocytosis and of the readily releasable pool at central synapses. PLoS One. 2014.02; 9 (2): e90004. ( PubMed , DOI )

  8. Hirate Yoshikazu, Sasaki Hiroshi: The role of angiomotin phosphorylation in the Hippo pathway during preimplantation mouse development. Tissue Barriers. 2014.01; 2 (1): e28127. ( PubMed , DOI )

  1. Takada Shuji, Sato Tempei, Ito Yoshiaki, Yamashita Satoshi, Kato Tomoko, Kawasumi Miyuri, Kanai-Azuma Masami, Igarashi Arisa, Kato Tomomi, Tamano Moe, Asahara Hiroshi: Targeted gene deletion of miRNAs in mice by TALEN system. PLoS One. 2013.10; 8 (10): e76004. ( PubMed , DOI )

  2. Hirate Yoshikazu, Hirahara Shino, Inoue Ken-Ichi, Suzuki Atsushi, Alarcon Vernadeth B, Akimoto Kazunori, Hirai Takaaki, Hara Takeshi, Adachi Makoto, Chida Kazuhiro, Ohno Shigeo, Marikawa Yusuke, Nakao Kazuki, Shimono Akihiko, Sasaki Hiroshi: Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos. Curr Biol. 2013.07; 23 (13): 1181-1194. ( PubMed , DOI )

  3. Harikae K, Miura K, Shinomura M, Matoba S, Hiramatsu R, Tsunekawa N, Kanai-Azuma M, Kurohmaru M, Morohashi KI, Kanai Y: Heterogeneity in sexual bipotentiality and plasticity of granulosa cells in developing mouse ovaries. J Cell Sci. 2013.07; 126 (Pt 13): 2834-2844. ( PubMed , DOI )

  4. Uemura Mami, Ozawa Aisa, Nagata Takumi, Kurasawa Kaoruko, Tsunekawa Naoki, Nobuhisa Ikuo, Taga Tetsuya, Hara Kenshiro, Kudo Akihiko, Kawakami Hayato, Saijoh Yukio, Kurohmaru Masamichi, Kanai-Azuma Masami, Kanai Yoshiakira: Sox17 haploinsufficiency results in perinatal biliary atresia and hepatitis in C57BL/6 background mice. Development. 2013.02; 140 (3): 639-648. ( PubMed , DOI )

  1. Hirate Yoshikazu, Cockburn Katie, Rossant Janet, Sasaki Hiroshi: Tead4 is constitutively nuclear, while nuclear vs. cytoplasmic Yap distribution is regulated in preimplantation mouse embryos. Proc Natl Acad Sci U S A. 2012.12; 109 (50): E3389-90; author reply E3391. ( PubMed , DOI )

  2. Sekiuchi M, Kudo A, Nakabayashi K, Kanai-Azuma M, Akimoto Y, Kawakami H, Yamada A: Expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of matrix metalloproteinases 2 and 1 in the glomeruli of human glomerular diseases: the results of studies using immunofluorescence, in situ hybridization, and immunoelectron microscopy. Clin Exp Nephrol. 2012.12; 16 (6): 863-874. ( PubMed , DOI )

  3. Nagai R, Shinomura M, Kishi K, Aiyama Y, Harikae K, Sato T, Kanai-Azuma M, Kurohmaru M, Tsunekawa N, Kanai Y: Dynamics of GFRalpha1-positive spermatogonia at the early stages of colonization in the recipient testes of W/Wnu male mice. Dev Dyn. 2012.08; 241 (8): 1374-1384. ( PubMed , DOI )

  4. Saund RS, Kanai-Azuma M, Kanai Y, Kim I, Lucero MT, and Saijoh Y: Gut endoderm is involved in the transfer of left-right asymmetry from the node to the lateral plate mesoderm in the mouse embryo. Development. 2012.07; 139 (13): 2426-2435. ( PubMed , DOI )

  5. Ken Morita, Fumihiko Nakamura, Yasuhiko Kamikubo, Naoaki Mizuno, Masashi Miyauchi, Go Yamamoto, Yasuhito Nannya, Motoshi Ichikawa, Mineo Kurokawa: Pituitary lymphoma developing within pituitary adenoma. Int J Hematol. 2012.06; 95 (6): 721-724. ( PubMed , DOI )

  6. Junji Kawada, Hisashi Wada, Midori Isobe, Sacha Gnjatic, Hiroyoshi Nishikawa, Achim A Jungbluth, Nami Okazaki, Akiko Uenaka, Yurika Nakamura, Shinichi Fujiwara, Naoaki Mizuno, Takashi Saika, Erika Ritter, Makoto Yamasaki, Hiroshi Miyata, Gerd Ritter, Roger Murphy, Ralph Venhaus, Linda Pan, Lloyd J Old, Yuichiro Doki, Eiichi Nakayama: Heteroclitic serological response in esophageal and prostate cancer patients after NY-ESO-1 protein vaccination. Int J Cancer. 2012.02; 130 (3): 584-592. ( PubMed , DOI )

  1. Matsui Takaaki, Thitamadee Siripong, Murata Tomoko, Kakinuma Hisaya, Nabetani Takuji, Hirabayashi Yoshio, Hirate Yoshikazu, Okamoto Hitoshi, Bessho Yasumasa: Canopy1, a positive feedback regulator of FGF signaling, controls progenitor cell clustering during Kupffer's vesicle organogenesis. Proc Natl Acad Sci U S A. 2011.06; 108 (24): 9881-9886. ( PubMed , DOI )

  2. Pfister S, Jones VJ, Power M, Truisi GL, Khoo PL, Steiner KA, Kanai-Azuma M, Kanai Y, Tam PP, Loebel DA: Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos. Int. J. Dev. Biol. 2011; 55 (1): 45-58. ( PubMed , DOI )

  3. Ogawa Y, Miura Y, Harazono A, Kanai-Azuma M, Akimoto Y, Kawakami H, Yamaguchi T, Toda T, Endo T, Tsubuki M, Yanoshita R: Proteomic analysis of two types of exosomes in human whole saliva. Biol. Pharm. Bull. 2011; 34 (1): 13-23. ( PubMed )

  4. Sato T, Aiyama Y, Ishii-Inagaki M, Hara K, Tsunekawa N, Harikae K, Uemura-Kamata M, Shinomura M, Zhu XB, Maeda S, Kuwahara-Otani S, Kudo A, Kawakami H, Kanai-Azuma M, Fujiwara M, Miyamae Y, Yoshida S, Seki M, Kurohmaru M, Kanai Y: Cyclical and patch-like GDNF distribution along the basal surface of Sertoli cells in mouse and hamster testes. PLoS ONE. 2011; 6 (12): e28367. ( PubMed , DOI )

  1. Tashiro F, Kanai-Azuma M, Miyazaki S, Kato M, Tanaka T, Toyoda S, Yamato E, Kawakami H, Miyazaki T, Miyazaki J: Maternal-effect gene Ces5/Ooep/Moep19/Floped is essential for oocyte cytoplasmic lattice formation and embryonic development at the maternal-zygotic stage transition. Genes Cells. 2010.08; 15 (8): 813-828. ( PubMed , DOI )

  2. Uemura M, Hara K, Shitara H, Ishii R, Tsunekawa N, Miura Y, Kurohmaru M, Taya C, Yonekawa H, Kanai-Azuma M, Kanai Y : Expression and function of mouse Sox17 gene in the specification of gallbladder/bile-duct progenitors during early foregut morphogenesis. Biochem. Biophys. Res. Commun. 2010.01; 391 (1): 357-363. ( PubMed , DOI )

  1. Hara K, Kanai-Azuma M, Uemura M, Shitara H, Taya C, Yonekawa H, Kawakami H, Tsunekawa N, Kurohmaru M, Kanai Y: Evidence for crucial role of hindgut expansion in directing proper migration of primordial germ cells in mouse early embryogenesis. Dev Biol. 2009.06; 330 (2): 427-439. ( PubMed , DOI )

  2. Ryuji Hiramatsu, Shogo Matoba, Masami Kanai-Azuma, Naoki Tsunekawa, Yuko Katoh-Fukui, Masamichi Kurohmaru, Ken-Ichirou Morohashi, Dagmar Wilhelm, Peter Koopman, Yoshiakira Kanai: A critical time window of Sry action in gonadal sex determination in mice. Development. 2009.01; 136 (1): 129-138. ( PubMed , DOI )

  1. Shogo Matoba, Ryuji Hiramatsu, Masami Kanai-Azuma, Naoki Tsunekawa, Kyoko Harikae, Hayato Kawakami, Masamichi Kurohmaru, Yoshiakira Kanai: Establishment of testis-specific SOX9 activation requires high-glucose metabolism in mouse sex differentiation. Dev. Biol. 2008.12; 324 (1): 76-87. ( PubMed , DOI )

  2. Takuo Mizukami, Yoshiakira Kanai, Masahiko Fujisawa, Masami Kanai-Azuma, Masamichi Kurohmaru, Yoshihiro Hayashi: Five azacytidine, a DNA methyltransferase inhibitor, specifically inhibits testicular cord formation and Sertoli cell differentiation in vitro. Mol. Reprod. Dev. 2008.06; 75 (6): 1002-1010. ( PubMed , DOI )

  3. Yuko Ogawa, Masami Kanai-Azuma, Yoshihiro Akimoto, Hayato Kawakami, Ryohei Yanoshita: Exosome-like vesicles with dipeptidyl peptidase IV in human saliva. Biol. Pharm. Bull. 2008.06; 31 (6): 1059-1062. ( PubMed )

  4. Yuko Ogawa, Masami Kanai-Azuma, Yoshihiro Akimoto, Hayato Kawakami, Ryohei Yanoshita: Exosome-like vesicles in Gloydius blomhoffii blomhoffii venom. Toxicon. 2008.05; 51 (6): 984-993. ( PubMed , DOI )

  5. Maryam Kabir-Salmani, Michiko N Fukuda, Masami Kanai-Azuma, Nesar Ahmed, Shigetatsu Shiokawa, Yoshihiro Akimoto, Keiji Sakai, Seishi Nagamori, Yoshikatsu Kanai, Kazuhiro Sugihara, Mitsutoshi Iwashita: The membrane-spanning domain of CD98 heavy chain promotes alpha(v)beta3 integrin signals in human extravillous trophoblasts. Mol. Endocrinol. 2008.03; 22 (3): 707-715. ( PubMed , DOI )

  1. Masafumi Shimoda, Masami Kanai-Azuma, Kenshiro Hara, Satsuki Miyazaki, Yoshiakira Kanai, Morito Monden, Jun-ichi Miyazaki: Sox17 plays a substantial role in late-stage differentiation of the extraembryonic endoderm in vitro. J. Cell. Sci. 2007.11; 120 (Pt 21): 3859-3869. ( PubMed , DOI )

  2. Rutherford Suzannah, Hirate Yoshikazu, Swalla Billie J: The Hsp90 capacitor, developmental remodeling, and evolution: the robustness of gene networks and the curious evolvability of metamorphosis. Crit Rev Biochem Mol Biol. 2007.09; 42 (5): 355-372. ( PubMed , DOI )

  3. Youhei Sakamoto, Kenshiro Hara, Masami Kanai-Azuma, Toshiyasu Matsui, Yutaroh Miura, Naoki Tsunekawa, Masamichi Kurohmaru, Yukio Saijoh, Peter Koopman, Yoshiakira Kanai: Redundant roles of Sox17 and Sox18 in early cardiovascular development of mouse embryos. Biochem. Biophys. Res. Commun. 2007.08; 360 (3): 539-544. ( PubMed , DOI )

  4. Mayuko Ishii, Tsuyoshi Tachiwana, Anshin Hoshino, Naoki Tsunekawa, Ryuji Hiramatsu, Shogo Matoba, Masami Kanai-Azuma, Hayato Kawakami, Masamichi Kurohmaru, Yoshiakira Kanai: Potency of testicular somatic environment to support spermatogenesis in XX/Sry transgenic male mice. Development. 2007.02; 134 (3): 449-454. ( PubMed , DOI )

  1. Toshiyasu Matsui, Masami Kanai-Azuma, Kenshiro Hara, Shogo Matoba, Ryuji Hiramatsu, Hayato Kawakami, Masamichi Kurohmaru, Peter Koopman, Yoshiakira Kanai: Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice. J. Cell. Sci. 2006.09; 119 (Pt 17): 3513-3526. ( PubMed , DOI )

  2. Jiho Sohn, JoAnne Natale, Li-Jin Chew, Shibeshih Belachew, Ying Cheng, Adan Aguirre, Judith Lytle, Brahim Nait-Oumesmar, Christophe Kerninon, Masami Kanai-Azuma, Yoshiakira Kanai, Vittorio Gallo: Identification of Sox17 as a transcription factor that regulates oligodendrocyte development. J. Neurosci. 2006.09; 26 (38): 9722-9735. ( PubMed , DOI )

  3. Hirate Yoshikazu, Okamoto Hitoshi: Canopy1, a novel regulator of FGF signaling around the midbrain-hindbrain boundary in zebrafish. Curr Biol. 2006.02; 16 (4): 421-427. ( PubMed , DOI )

  1. Maki Ishii, Yoshiakira Kanai, Masami Kanai-Azuma, Youichi Tajima, Tay Tat Wei, Tomohide Kidokoro, Yutaka Sanai, Masamichi Kurohmaru, Yoshihiro Hayashi: Adhesion activity of fetal gonadal cells to EGF and discoidin domains of milk fat globule-EGF factor 8 (MFG-E8), a secreted integrin-binding protein which is transiently expressed in mouse early gonadogenesis. Anat. Embryol. 2005.07; 209 (6): 485-494. ( PubMed , DOI )

  2. Shogo Matoba, Yoshiakira Kanai, Tomohide Kidokoro, Masami Kanai-Azuma, Hayato Kawakami, Yoshihiro Hayashi, Masamichi Kurohmaru: A novel Sry-downstream cellular event which preserves the readily available energy source of glycogen in mouse sex differentiation. J. Cell. Sci. 2005.04; 118 (Pt 7): 1449-1459. ( PubMed , DOI )

  3. Tomohide Kidokoro, Shogo Matoba, Ryuji Hiramatsu, Masahiko Fujisawa, Masami Kanai-Azuma, Choji Taya, Masamichi Kurohmaru, Hayato Kawakami, Yoshihiro Hayashi, Yoshiakira Kanai, Hiromichi Yonekawa: Influence on spatiotemporal patterns of a male-specific Sox9 activation by ectopic Sry expression during early phases of testis differentiation in mice. Dev. Biol. 2005.02; 278 (2): 511-525. ( PubMed , DOI )

  1. Takeshi Sato, Yoshiakira Kanai, Takashi Noma, Masami Kanai-Azuma, Shinichiro Taya, Toshiyasu Matsui, Maki Ishii, Hayato Kawakami, Masamichi Kurohmaru, Kozo Kaibuchi, Stephen A Wood, Yoshihiro Hayashi: A close correlation in the expression patterns of Af-6 and Usp9x in Sertoli and granulosa cells of mouse testis and ovary. Reproduction. 2004.11; 128 (5): 583-594. ( PubMed , DOI )

  2. Miyashita Toshio, Yeo Sang-Yeob, Hirate Yoshikazu, Segawa Hiroshi, Wada Hironori, Little Melissa H, Yamada Toshiya, Takahashi Naoki, Okamoto Hitoshi: PlexinA4 is necessary as a downstream target of Islet2 to mediate Slit signaling for promotion of sensory axon branching. Development. 2004.08; 131 (15): 3705-3715. ( PubMed , DOI )

  3. Toshimitsu Fuse, Yoshiakira Kanai, Masami Kanai-Azuma, Misao Suzuki, Kazuhiro Nakamura, Hisashi Mori, Yoshihiro Hayashi, Masayoshi Mishina: Conditional activation of RhoA suppresses the epithelial to mesenchymal transition at the primitive streak during mouse gastrulation. Biochem. Biophys. Res. Commun. 2004.06; 318 (3): 665-672. ( PubMed , DOI )

  4. Okamoto Hitoshi, Hirate Yoshikazu, Ando Hideki: Systematic identification of factors in zebrafish regulating the early midbrain and cerebellar development by odered differential display and caged mRNA technology. Front Biosci. 2004.01; 9 93-99. ( PubMed )

  1. Hiramatsu R, Kanai Y, Mizukami T, Ishii M, Matoba S, Kanai-Azuma M, Kurohmaru M, Kawakami H, Hayashi Y: Regionally distinct potencies of mouse XY genital ridge to initiate testis differentiation dependent on anteroposterior axis. Dev Dyn. 2003.10; 228 (2): 247-253. ( PubMed , DOI )

  2. Masaharu Kotani, Youichi Tajima, Taka Osanai, Atsushi Irie, Ken Iwatsuki, Masami Kanai-Azuma, Masato Imada, Hiroko Kato, Hiroshi Shitara, Hideo Kubo, Hitoshi Sakuraba: Complementary DNA cloning and characterization of RANDAM-2, a type I membrane molecule specifically expressed on glutamatergic neuronal cells in the mouse cerebrum. J. Neurosci. Res. 2003.09; 73 (5): 603-613. ( PubMed , DOI )

  3. Patrick P L Tam, Masami Kanai-Azuma, Yoshiakira Kanai: Early endoderm development in vertebrates: lineage differentiation and morphogenetic function. Curr. Opin. Genet. Dev. 2003.08; 13 (4): 393-400. ( PubMed )

  4. Kuniko Nakano, Masami Kanai-Azuma, Yoshiakira Kanai, Kenji Moriyama, Kazumori Yazaki, Yoshihiro Hayashi, Naomi Kitamura: Cofilin phosphorylation and actin polymerization by NRK/NESK, a member of the germinal center kinase family. Exp. Cell Res. 2003.07; 287 (2): 219-227. ( PubMed )

  5. Hirate Yoshikazu, Okamoto Hitoshi, Yamasu Kyo: Structure of the zebrafish fasciclin I-related extracellular matrix protein (betaig-h3) and its characteristic expression during embryogenesis. Gene Expr Patterns. 2003.06; 3 (3): 331-336. ( PubMed )

  1. Takashi Noma, Yoshiakira Kanai, Masami Kanai-Azuma, Maki Ishii, Masahiko Fujisawa, Masamichi Kurohmaru, Hayato Kawakami, Stephen A Wood, Yoshihiro Hayashi: Stage- and sex-dependent expressions of Usp9x, an X-linked mouse ortholog of Drosophila Fat facets, during gonadal development and oogenesis in mice. Mech. Dev. 2002.12; 119 Suppl 1 S91-S95. ( PubMed )

  2. Takashi Noma, Yoshiakira Kanai, Masami Kanai-Azuma, Maki Ishii, Masahiko Fujisawa, Masamichi Kurohmaru, Hayato Kawakami, Stephen A Wood, Yoshihiro Hayashi: Stage- and sex-dependent expressions of Usp9x, an X-linked mouse ortholog of Drosophila Fat facets, during gonadal development and oogenesis in mice. Gene Expr. Patterns. 2002.11; 2 (1-2): 87-91. ( PubMed )

  3. Masami Kanai-Azuma, Yoshiakira Kanai, Jacqueline M Gad, Youichi Tajima, Choji Taya, Masamichi Kurohmaru, Yutaka Sanai, Hiromichi Yonekawa, Kazumori Yazaki, Patrick P L Tam, Yoshihiro Hayashi: Depletion of definitive gut endoderm in Sox17-null mutant mice. Development. 2002.05; 129 (10): 2367-2379. ( PubMed )

  1. Pantaleon M, Kanai-Azuma M, Mattick JS, Kaibuchi K, Kaye PL, Wood SA: FAM deubiquitylating enzyme is essential for preimplantation mouse embryo development. Mech Dev. 2001.12; 109 (2): 151-160. ( PubMed )

  2. Y Hirate, M Mieda, T Harada, K Yamasu, H Okamoto: Identification of ephrin-A3 and novel genes specific to the midbrain-MHB in embryonic zebrafish by ordered differential display. Mech. Dev.. 2001.09; 107 (1-2): 83-96. ( PubMed )

  3. H Segawa, T Miyashita, Y Hirate, S Higashijima, N Chino, K Uyemura, Y Kikuchi, H Okamoto: Functional repression of Islet-2 by disruption of complex with Ldb impairs peripheral axonal outgrowth in embryonic zebrafish. Neuron. 2001.05; 30 (2): 423-436. ( PubMed )

  4. Sekine-Aizawa Y, Hama E, Watanabe K, Tsubuki S, Kanai-Azuma M, Kanai Y, Arai H, Aizawa H, Iwata N, Saido TC: Matrix metalloproteinase (MMP) system in brain: identification and characterization of brain-specific MMP highly expressed in cerebellum. Eur J Neurosci. 2001.03; 13 (5): 935-948. ( PubMed )

  1. Kanai Y, Kanai-Azuma M, Tajima Y, Birk OS, Hayashi Y, Sanai Y: Identification of a stromal cell type characterized by the secretion of a soluble integrin-binding protein, MFG-E8, in mouse early gonadogenesis. Mech Dev. 2000.09; 96 (2): 223-227. ( PubMed )

  2. Kanai-Azuma M, Mattick JS, Kaibuchi K, Wood SA: Co-localization of FAM and AF-6, the mammalian homologues of Drosophila faf and canoe, in mouse eye development. Mech Dev. 2000.03; 91 (1-2): 383-386. ( PubMed )

  1. Kanai-Azuma M, Kanai Y, Okamoto M, Hayashi Y, Yonekawa H, Yazaki K: Nrk: a murine X-linked NIK (Nck-interacting kinase)-related kinase gene expressed in skeletal muscle. Mech Dev. 1999.12; 89 (1-2): 155-159. ( PubMed )

  2. Taya S, Yamamoto T, Kanai-Azuma M, Wood SA, Kaibuchi K: The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin. Genes Cells. 1999.12; 4 (12): 757-767. ( PubMed )

  3. Y Hirate, K Tomita, S Yamamoto, K Kobari, I Uemura, K Yamasu, T Suyemitsu: Association of the sea urchin EGF-related peptide, EGIP-D, with fasciclin I-related ECM proteins from the sea urchin Anthocidaris crassispina. Dev. Growth Differ.. 1999.08; 41 (4): 483-494. ( PubMed )

  1. Taya S, Yamamoto T, Kano K, Kawano Y, Iwamatsu A, Tsuchiya T, Tanaka K, Kanai-Azuma M, Wood SA, Mattick JS, Kaibuchi K: The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme. J Cell Biol. 1998.08; 142 (4): 1053-1062. ( PubMed )

  1. Y Fujita, Y Hirate, T Hiyama, K Yamasu, T Suyemitsu, K Ishihara: Purification of EGIP-D-binding protein from the embryos of the sea urchin Anthocidaris crassispina. Zool. Sci.. 1997.12; 14 (6): 931-934. ( PubMed )

  2. Kanai-Azuma M, Kanai Y, Matsuda H, Kurohmaru M, Tachi C, Yazaki K, Hayashi Y: Nerve growth factor promotes giant-cell transformation of mouse trophoblast cells in vitro. Biochem Biophys Res Commun. 1997.02; 231 (2): 309-315. ( PubMed , DOI )

  1. Tanemura K, Kanai Y, Kanai-Azuma M, Kurohmaru M, Kuramoto K, Yazaki K, Hayashi Y: Reinitiation of spermatogonial mitotic differentiation in inactive old BDF1 mouse seminiferous tubules transplanted to W/Wv mouse testis. Biol Reprod. 1996.12; 55 (6): 1237-1242. ( PubMed )

  2. Kanai Y, Kanai-Azuma M, Noce T, Saido TC, Shiroishi T, Hayashi Y, Yazaki K: Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis. J Cell Biol. 1996.05; 133 (3): 667-681. ( PubMed )

  1. Kanai Y, Kanai-Azuma M, Kurohmaru M, Yazaki K, Hayashi Y: Effects of extracellular matrix on differentiation of mouse fetal gonads in the absence of mesonephros in vitro. Microsc Res Tech. 1995.12; 32 (5): 437-448. ( PubMed , DOI )

  1. Kanai-Azuma M, Kanai Y, Kurohmaru M, Sakai S, Hayashi Y: Insulin-like growth factor (IGF)-I stimulates proliferation and migration of mouse ectoplacental cone cells, while IGF-II transforms them into trophoblastic giant cells in vitro. Biol Reprod. 1993.02; 48 (2): 252-261. ( PubMed )

  1. Kanai Y, Kawakami H, Kanai-Azuma M, Kurohmaru M, Hirano H, Hayashi Y: Changes in intracellular and cell surface localization of Le(x) epitope during germ cell differentiation in fetal mice. J Vet Med Sci. 1992.04; 54 (2): 297-303. ( PubMed )

  1. Enomoto Noriyuki, Homma Sakae, Inase Naohiko, Kondoh Yasuhiro, Saraya Takeshi, Takizawa Hajime, Inoue Yoshikazu, Ishii Hiroshi, Taguchi Yoshio, Izumi Shinyu, Yamano Yasuhiko, Tanino Yoshinori, Nishioka Yasuhiko, Toyoshima Mikio, Yokomura Koshi, Imokawa Shiro, Koshimizu Naoki, Sano Takehisa, Akamatsu Taisuke, Mukae Hiroshi, Kato Motoyasu, Hamada Naoki, Chiba Hirofumi, Akagawa Shinobu, Muro Shigeo, Uruga Hironori, Matsuda Hiroyuki, Kaida Yusuke, Kanai Miho, Mori Kazutaka, Masuda Masafumi, Hozumi Hironao, Fujisawa Tomoyuki, Nakamura Yutaro, Ogawa Noriyoshi, Suda Takafumi: Prospective nationwide multicentre cohort study of the clinical significance of autoimmune features in idiopathic interstitial pneumonias THORAX. 2021.07; ( DOI )

  1. 高見 尚平, 上村 麻美, Watcharapon Promsut, 宮崎 奈々惠, 平松 竜司, 平手 良和, 石原 玄基, 金井 正美, 藤代 準, 金井 克晃: Indocyanine Greenを用いたSox17+/-胆道閉鎖症モデルマウスの肝外胆管ライブイメージング 日本獣医学会学術集会講演要旨集. 2020.10; 163回 179. ( 医中誌 )

  2. 上村 麻実, 松本 悠貴, 高見 尚平, 平松 竜司, 平手 良和, 藤代 準, 金井 正美, 金井 克晃, 石原 玄基: 獣医療保険金情報を用いた犬・猫の胆汁うっ滞性疾患における候補品種の選抜および遺伝子多型解析 日本獣医学会学術集会講演要旨集. 2020.10; 163回 179. ( 医中誌 )

  3. 蓬田 裕, 伊藤 日加瑠, 平手 良和, 宮坂 尚幸, 金井 正美: マウス・ヒトにおけるNrk遺伝子発現の比較検討 日本獣医学会学術集会講演要旨集. 2020.10; 163回 183. ( 医中誌 )

  1. Enomoto N., Homma S. A., Inase N., Takizawa H., Inoue Y., Ishii H., Taguchi Y., Izumi S., Yamano Y., Tanino Y., Nishioka Y., Toyoshima M., Yokomura K., Imokawa S., Koshimizu N., Sano T., Akamatsu T., Mukae H., Kato M., Hamada N., Takahashi H., Akagawa S., Muro S., Uruga H., Matsuda H., Kaida Y., Kanai M., Masuda M., Suda T.: Prognostic Analysis of Idiopathic Interstitial Pneumonias with Rheumatologic Features: A Prospective Multicenter Cohort Study (PAIR Cohort Study) AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2019; 199

  1. 平手良和: マウス発生工学の技術革新 基礎老化研究. 2018.09; 42 (3): 31-36.

  2. 平手 良和: 【発生工学の老化・疾患研究への応用】マウス発生工学の技術革新 基礎老化研究. 2018.09; 42 (3): 31-36. ( 医中誌 )

  3. 今井松 健也, 平松 竜司, 平手 良和, 金井 正美, 金井 克晃: シングルセルRNA-seq解析によるマウス胎子卵巣のheterogeneity 日本獣医学会学術集会講演要旨集. 2018.08; 161回 289. ( 医中誌 )

  4. 中野 有紀, 平手 良和, 上村 麻実, 金井 克晃, 金井 正美: TRECK法を用いた子宮内膜上皮置換法の確立 日本獣医学会学術集会講演要旨集. 2018.08; 161回 296. ( 医中誌 )

  5. 潮田 裕紀, 高瀬 比菜子, 上村 麻実, 平手 良和, 平松 竜司, 金井 正美, 金井 克晃: luminal flowを形成する精巣網上皮でのマウスSox17遺伝子の役割 日本獣医学会学術集会講演要旨集. 2018.08; 161回 295. ( 医中誌 )

  6. 金井 正美: 環境要因などによる着床障害の原因追求とその治療の基礎 女性健康科学研究会受賞研究報告集. 2018.05; 7 (1): 21-24. ( 医中誌 )

  7. 金井正美: 環境要因などによる着床障害の原因追求とその治療の基礎 女性健康科学研究会誌. 2018.02; 7 (1): 3-6.

  1. 五十嵐 瞳, 平松 竜司, 上村 麻実, 平手 良和, 九郎丸 正道, 吉村 祐貴, 橋下 晴夫, 末水 洋志, 金井 正美, 金井 克晃: マウス壁側内胚葉細胞の維持とSOX17、SOX7の相補的機能 生命科学系学会合同年次大会. 2017.12; 2017年度 [2P-0730]. ( 医中誌 )

  2. 平手 良和, 早川 佳那, 中野 有紀, 上村 麻実, 三浦 健人, 金井 克晃, 金井 正美: マウス子宮上皮における転写因子Sox17の発現は着床の成立に必須である 生命科学系学会合同年次大会. 2017.12; 2017年度 [2P-0713]. ( 医中誌 )

  3. 早川 佳那, 平手 良和, 上村 麻実, 三浦 健人, 金井 克晃, 金井 正美: Sox17ヘテロ変異雌マウスの子宮における着床不全のメカニズム解析 日本獣医学会学術集会講演要旨集. 2017.08; 160回 314. ( 医中誌 )

  4. 五十嵐 瞳, 上村 麻実, 平松 竜司, 平手 良和, 橋本 晴夫, 末水 洋志, 金井 克晃, 九郎丸 正道, 金井 正美: マウスSox17は胎盤辺縁部の壁側内胚葉の正常な分化、維持に必須である 日本獣医学会学術集会講演要旨集. 2017.08; 160回 314. ( 医中誌 )

  5. 村田 千晴, 三浦 健人, 東山 大毅, 平手 良和, 金井 正美, 平松 竜司, 九郎丸 正道, 金井 克晃: Amh欠損雄マウスにおける遺残子宮の形態学的解析 日本獣医学会学術集会講演要旨集. 2017.08; 160回 313. ( 医中誌 )

  1. 金井正美、上村麻実、金井克晃: ホールマウントin situハイブリダイゼーション法とその応用（B.遺伝子発現の解析技術、見るバイオサイエンス-基礎から最先端技術まで） 組織細胞化学. 2011.07; 77-82.

  1. 金井正美、川上速人、原健士朗、金井克晃: ホールマウントin situハイブリダイゼーション(B.in situハイブリダイゼーション法） 組織細胞化学. 2008.07; 51-58.

  1. 金井正美、川上速人、平松竜司、金井克晃: ホールマウントin situハイブリダイゼーション：up to date(Ⅱ.遺伝子組織化学-in situ hybridization) 組織細胞化学. 2006.07; 57-62.

  1. 金井正美、金井克晃、川上速人: ISH法の発生学への応用(Ⅱ.in situ hybridization(ISH)法) 組織細胞化学. 2004.07; 47-52.

  1. 金井正美、金井克晃: 全線標本を用いたin situハイブリダイゼーション法 組織細胞化学. 2002.07; 111-118.

  2. 金井克晃、水上拓郎、金井正美、平松竜司、城所知秀、藤澤正彦、九郎丸正道、林良博: 哺乳類の生殖腺の性分化：SryからMis/テストステロン分泌まで 日本比較内分泌学会ニュース. 2002; 2002 (106): 14-21. ( DOI )

  1. 金井正美、金井克晃: SOX(Sry-type HMG box)-4ノックアウトマウスデーターブック Molecular medicine. 1997.12; (34): 463-464.

  2. 金井正美、金井克晃: SOX(Sry-type HMG box)遺伝子 ホルモンと臨牀. 1997.01; 45 (1): 79-84.

このページの先頭へ▲