1. Hatano M, Akiyama Y, Shimada S, Yagi K, Akahoshi K, Itoh M, Tanabe M, Ogawa Y, Tanaka S: Loss of KDM6B epigenetically confers resistance to lipotoxicity in nonalcoholic fatty liver disease-related hepatocellular carcinoma. Hepatology Communications. 2023.10; 7 (10): e0277.

  2. Murota Y, Nagane M, Wu M, Santra M, Venkateswaran S, Tanaka S, Bradley M, Taga T, Tabu K: A niche-mimicking polymer hydrogel-based approach to identify molecular targets for tackling human pancreatic cancer stem cells. Inflammation and regeneration. 2023.09; 43 (1): 46. ( PubMed , DOI )

  3. Yamane M, Ishikawa Y, Asano D, Watanabe S, Ueda H, Akahoshi K, Ono H, Kudo A, Tanaka S, Sugiyama Y, Muro S, Akita K, Tanabe M: Surgical anatomy of the dorsal pancreatic artery: Considering embryonic development. Pancreatology. 2023.09; 23 (6): 697-703. ( PubMed , DOI )

  4. Yamamoto Y, Shimada S, Akiyama Y, Tsukihara S, Sugimoto R, Kabashima A, Tokunaga M, Kinugasa Y, Kawakami Y, Tanaka S: RTP4 silencing provokes tumor-intrinsic resistance to immune checkpoint blockade in colorectal cancer. Journal of Gastroenterology. 2023.06; 58 (6): 540-553.

  5. Morimoto K, Ueda H, Asano D, Ishikawa Y, Watanabe S, Akahoshi K, Ono H, Kobayashi M, Okamoto R, Tanaka S, Tanabe M: Incidence and Mechanism of Refractory Postoperative Cholangitis After Hepatectomy with Hepaticojejunostomy. Journal of Gastrointestinal Surgery. 2023.06; 27 (8): 1668-1676.

  6. Yagi K, Ono H, Kudo A, Kinowaki Y, Asano D, Watanabe S, Ishikawa Y, Ueda H, Akahoshi K, Tanaka S, Tanabe M: MGMT is frequently inactivated in pancreatic NET-G2 and is associated with the therapeutic activity of STZ-based regimens. Sci Rep. 2023.05; 13 (1): 7535. ( PubMed , DOI )

  7. Ono H, Murase Y, Yamashita H, Kato T, Asano D, Ishikawa Y, Watanabe S, Ueda H, Akahoshi K, Ogawa K, Kudo A, Akiyama Y, Tanaka S, Tanabe M: RRM1 is mediated by histone acetylation through gemcitabine resistance and contributes to invasiveness and ECM remodeling in pancreatic cancer. International Journal of Oncology. 2023.04; 62 (4): 51.

  8. Ishii T, Akiyama Y, Shimada S, Kabashima A, Asano D, Watanabe S, Ishikawa Y, Ueda H, Akahoshi K, Ogawa K, Ono H, Kudo A, Tanabe M, Tanaka S: Identification of a novel target of SETD1A histone methyltransferase and the clinical significance in pancreatic cancer. Cancer Science. 2023.02; 114 (2): 463-476.

  9. Shimada S, Tanaka S: The chronicles of hepatocellular carcinoma classification: subtyping, modeling and treatment. Hepatology. 2023; in press.

  1. Ichihara M, Takahashi H, Nishida N, Ivan C, Okuzaki D, Yokoyama Y, Ohtsuka M, Miyoshi N, Uemura M, Tanaka S, Calin G, Mori M, Doki Y, Eguchi, H, Yamamoto H: Long noncoding RNA 01534 maintains cancer stemness by down-regulating endoplasmic reticulum stress response in colorectal cancer Annals of Gastroenterological Surgery. 2022.12; 7 (3): 458-470.

  2. Ichihara M, Takahashi H, Nishida N, Ivan C, Okuzaki D, Yokoyama Y, Ohtsuka M, Miyoshi N, Uemura M, Tanaka S, Calin G, Mori M, Doki Y, Eguchi, H, Yamamoto H: Long noncoding RNA 01534 maintains cancer stemness by down-regulating endoplasmic reticulum stress response in colorectal cancer Annals of Gastroenterological Surgery. 2022.12; 7 (3): 458-470. ( PubMed )

  3. Ishii Takeshi, Akiyama Yoshimitsu, Shimada Shu, Kabashima Ayano, Asano Daisuke, Watanabe Shuichi, Ishikawa Yoshiya, Ueda Hiroki, Akahoshi Keiichi, Ogawa Kosuke, Ono Hiroaki, Kudo Atsushi, Tanabe Minoru, Tanaka Shinji: Identification of a novel target of SETD1A histone methyltransferase and the clinical significance in pancreatic cancer CANCER SCIENCE. 2022.11; 114 (2): 463-476.

  4. Asano D, Kudo A, Akahoshi K, Maekawa A, Murase Y, Ogawa K, Ono H, Ban D, Tanaka S, Tanabe M: Curative Surgery and Ki-67 Value Rather than Tumor Differentiation Predict the Survival of Patients with High-grade Neuroendocrine Neoplasms. Annals of Surgery. 2022.08; 276 (2): e108-e113.

  5. Shimada S, Tanaka S: Molecular targeted drugs, comprehensive classification and preclinical models for the implementation of precision immune oncology in hepatocellular carcinoma International Journal of Clinical Oncology. 2022.07; 27 (7): 1101-1109. ( PubMed , DOI )

  6. Kabashima A, Matsuo Y, Ito S, Akiyama Y, Ishii T, Shimada S, Masamune A, Tanabe M, Tanaka S: cGAS-STING signaling encourages immune cell overcoming of fibroblast barricades in pancreatic cancer. Scientific Reports. 2022.06; 12 (1): 10466. ( PubMed , DOI )

  7. Kato T, Kudo A, Kinowaki Y, Ishikawa Y, Watanabe S, Akahoshi K, Ogawa K, Ono H, Ban D, Tanaka S, Tanabe M: A novel classification of portal venous tumor invasion to predict residual tumor status after surgery in patients with pancreatic neuroendocrine neoplasms. J Cancer Res Clin Oncol. 2022.04; 148 (4): 931-941. ( PubMed , DOI )

  8. Maekawa A, Kudo A, Kishino M, Murase Y, Watanabe S, Ishikawa Y, Ueda H, Akahoshi K, Ogawa K, Ono H, Tanaka S, Kinowaki Y, Tanabe M: Hormonal tumor mapping for liver metastases of gastroenteropancreatic neuroendocrine neoplasms: a novel therapeutic strategy. J Cancer Res Clin Oncol. 2022.03; 148 (3): 697-706. ( PubMed , DOI )

  9. Wang J, Hirose H, Yokoyama Y, Ikeshima R, Tsujimura N, Bonkobara S, Takeda K, Hata T, Inoue A, Hiraki M, Ohtsuka M, Nishida N, Takahashi H, Haraguchi N, Tanaka S, Wu X, Mori M, Yamamoto H.: Functional assessment of miR-1291 in colon cancer cells. International Journal of Oncology. 2022.02; 60 (2): 13. ( PubMed , DOI )

  10. Zhang M, Sugita I, Komura D, Katoh H, Shimada S, Inazawa J, Tanaka S, Ishikawa S: Genomic landscape of a mouse model of diffuse-type gastric adenocarcinoma Gastric Cancer. 2022.01; 25 (1): 83-95. ( PubMed )

  11. Ichihara M, Takahashi H, Nishida N, Ivan C, Okuzaki D, Yokoyama Y, Ohtsuka M, Miyoshi N, Uemura M, Tanaka S, Calin G, Mori M, Doki Y, Eguchi, H, Yamamoto H: Long noncoding RNA 01534 maintains cancer stemness by down-regulating endoplasmic reticulum stress response in colorectal cancer. Annals of Gastroenterological Surgery. 2022; 7 (3): 458-470. ( PubMed , DOI )

  12. Yamamoto Y, Shimada S, Akiyama Y, Tsukihara S, Sugimoto R, Kabashima A, Tokunaga M, Kinugasa Y, Kawakami Y, Tanaka S: RTP4 silencing provokes tumor-intrinsic resistance to immune checkpoint blockade in colorectal cancer. Journal of Gastroenterology. 2022;

  13. Ishii T, Akiyama Y, Shimada S, Kabashima A, Asano D, Watanabe S, Ishikawa Y, Ueda H, Akahoshi K, Ogawa K, Ono H, Kudo A, Tanabe M, Tanaka S: Identification of a novel target of SETD1A histone methyltransferase and the clinical significance in pancreatic cancer Cancer Science. 2022;

  1. Murase Yoshiki, Ono Hiroaki, Ogawa Kosuke, Yoshioka Risa, Ishikawa Yoshiya, Ueda Hiroki, Akahoshi Keiichi, Ban Daisuke, Kudo Atsushi, Tanaka Shinji, Tanabe Minoru: Inhibitor library screening identifies ispinesib as a new potential chemotherapeutic agent for pancreatic cancers(和訳中) Cancer Science. 2021.11; 112 (11): 4641-4654. ( ichushi )

  2. Yoshiki Murase, Hiroaki Ono, Kosuke Ogawa, Risa Yoshioka, Yoshiya Ishikawa, Hiroki Ueda, Keiichi Akahoshi, Daisuke Ban, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe: Inhibitor library screening identifies ispinesib as a new potential chemotherapeutic agent for pancreatic cancers. Cancer Sci. 2021.11; 112 (11): 4641-4654. ( PubMed , DOI )

  3. Taniai Tomohiko, Shirai Yoshihiro, Shimada Yohta, Hamura Ryoga, Yanagaki Mitsuru, Takada Naoki, Horiuchi Takashi, Haruki Koichiro, Furukawa Kenei, Uwagawa Tadashi, Tsuboi Kazuhito, Okamoto Yasuo, Shimada Shu, Tanaka Shinji, Ohashi Toya, Ikegami Toru: Inhibition of acid ceramidase elicits mitochondrial dysfunction and oxidative stress in pancreatic cancer cells(和訳中) Cancer Science. 2021.11; 112 (11): 4570-4579. ( ichushi )

  4. Aramaki O, Takayama T, Moriguchi M, Sakamoto H, Yodono H, Kokudo N, Yamanaka N, Kawasaki S, Sasaki Y, Kubota K, Otsuji E, Tanaka S, Matsuyama Y, Fujii M.: Arterial chemoembolisation with cisplatin versus epirubicin for hepatocellular carcinoma (ACE 500 study): A multicentre, randomised controlled phase 2/3 trial. European Journal of Cancer. 2021.09; 157 373-382.

  5. Taniai T, Shirai Y, Shimada Y, Hamura R, Yanagaki M, Takada N, Horiuchi T, Haruki K, Furukawa K, Uwagawa T, Tsuboi K, Okamoto Y, Shimada S, Tanaka S, Ohashi T, Ikegami T.: Inhibition of acid ceramidase elicits mitochondrial dysfunction and oxidative stress in pancreatic cancer cells. Cancer Science. 2021.09; 112 (11): 4570-4579. ( DOI )

  6. Matsui S, Ono H, Asano D, Ishikawa Y, Ueda H, Akahoshi K, Ogawa K, Kudo A, Tanaka S, Tanabe M: Pancreatic metastasis from renal cell carcinoma presenting as gastrointestinal hemorrhage: a case report. Journal of surgical case reports. 2021.08; 2021 (8): rjab368. ( PubMed , DOI )

  7. Zhang M, Sugita I, Komura D, Katoh H, Shimada S, Inazawa J, Tanaka S, Ishikawa S: Genomic landscape of a mouse model of diffuse-type gastric adenocarcinoma. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 2021.08; ( PubMed , DOI )

  8. Akasu M, Shimada S, Kabashima A, Akiyama Y, Shimokawa M, Akahoshi K, Kudo A, Yamaoka S, Tanabe M, Tanaka S: Intrinsic activation of β-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to immune evasion in hepatocellular carcinoma. Scientific Reports. 2021.08; 11 (1):

  9. Matsui S, Ono H, Asano D, Ishikawa Y, Ueda H, Akahoshi K, Ogawa K, Kudo A, Tanaka S, Tanabe M: Pancreatic metastasis from renal cell carcinoma presenting as gastrointestinal hemorrhage: a case report. Jornal of Surgical Case Reports. 2021.08; 2021 (8):

  10. Akasu M, Shimada S, Kabashima A, Akiyama Y, Shimokawa M, Akahoshi K, Kudo A, Yamaoka S, Tanabe M, Tanaka S: Intrinsic activation of β-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to immune evasion in hepatocellular carcinoma. Scientific reports. 2021.08; 11 (1): 16732. ( PubMed , DOI )

  11. Kato T, Ono H, Fujii M, Akahoshi K, Ogura T, Ogawa K, Ban D, Kudo A, Tanaka S, Tanabe M: Cytoplasmic RRM1 activation as an acute response to gemcitabine treatment is involved in drug resistance of pancreatic cancer cells. PLoS One. 2021.06; 16 (6):

  12. Hiroyuki Ishida, Yoshiya Ishikawa, Keiichi Akahoshi, Hiroki Ueda, Koichiro Morimoto, Hironari Yamashita, Kosuke Ogawa, Hiroaki Ono, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe.: Laparoscopic distal pancreatectomy in a patient with aberrant splenic artery originating from the superior mesenteric artery: A case report 2021.05; 100 (18): e25704.

  13. Ono H, Kato T, Murase Y, Nakamura Y, Ishikawa Y, Watanabe S, Akahoshi K, Ogura T, Ogawa K, Ban D, Kudo A, Akiyama Y, Tanaka S, Ito H, Tanabe M: C646 inhibits G2/M cell cycle-related proteins and potentiates anti-tumor effects in pancreatic cancer. Scientific Reports. 2021.05; 11 (1): ( PubMed , DOI )

  14. Iwao Y, Ban D, Muro S, Kudo A, Tanaka S, Menon K, Tanabe M: Extraordinary first jejunal arterial variation associated with annular pancreas undergoing pancreaticoduodenectomy for pancreatic cancer: a case report. Surgical and Radiologic Anatomy. 2021.05; 43 (5): 805-810.

  15. Toshitaka Sugawara, Daisuke Ban, Jo Nishino, Shuichi Watanabe, Aya Maekawa, Yoshiya Ishikawa, Keiichi Akahoshi, Kosuke Ogawa, Hiroaki Ono, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe: Prediction of early recurrence of pancreatic ductal adenocarcinoma after resection PLoS One. 2021.04; 16 (4): e0249885.

  16. Fukuda T, Bouchi R, Takeuchi T, Amo-Shiinoki K, Kudo A, Tanaka S, Tanabe M, Akashi T, Hirayama K, Odamaki T, Igarashi M, Kimura I, Tanabe K, Tanizawa Y, Yamada T, Ogawa Y: Importance of Intestinal Environment and Cellular Plasticity of Islets in the Development of Postpancreatectomy Diabetes. Diabetes Care. 2021.04; 44 (4): 1002-1011. ( PubMed , DOI )

  17. Maekawa A, Kudo A, Kishino M, Murase Y, Watanabe S, Ishikawa Y, Ueda H, Akahoshi K, Ogawa K, Ono H, Tanaka S, Kinowaki Y, Tanabe M.: Hormonal tumor mapping for liver metastases of gastroenteropancreatic neuroendocrine neoplasms: a novel therapeutic strategy Journal of Cancer Research and Clinical Oncology. 2021.04; published online

  18. Tatsuya Fukuda, Ryotaro Bouchi, Takato Takeuchi, Kikuko Amo-Shiinoki, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe, Takumi Akashi, Kazuhiro Hirayama, Toshitaka Odamaki, Miki Igarashi, Ikuo Kimura, Katsuya Tanabe, Yukio Tanizawa, Tetsuya Yamada, Yoshihiro Ogawa: Importance of Intestinal Environment and Cellular Plasticity of Islets in the Development of Postpancreatectomy Diabetes. Diabetes Care. 2021.04; 44 (4): 1002-1011. ( PubMed , DOI )

  19. Yoshiki Murase, Atsushi Kudo, Keiichi Akahoshi, Aya Maekawa, Yoshiya Ishikawa, Hiroki Ueda, Kosuke Ogawa, Hiroaki Ono, Shinji Tanaka, Minoru Tanabe: Surgery after sunitinib administration to improve survival of patients with advanced pancreatic neuroendocrine neoplasms Annals of Gastroenterological Surgery. 2021.03; 0 (0): 1-9.

  20. Amo-Shiinoki K, Tanabe K, Hoshii Y, Matsui H, Harano R, Fukuda T, Takeuchi T, Bouchi R, Takagi T, Hatanaka M, Takeda K, Okuya S, Nishimura W, Kudo A, Tanaka S, Tanabe M, Akashi T, Yamada T, Ogawa Y, Ikeda E, Nagano H, Tanizawa Y: Islet cell dedifferentiation is a pathologic mechanism of long-standing progression of type 2 diabetes. JCI insight. 2021.01; 6 (1):

  21. Kabashima Ayano, Shimada Shu, Shimokawa Masahiro, Akiyama Yoshimitsu, Tanabe Minoru, Tanaka Shinji: Molecular and immunological paradigms of hepatocellular carcinoma: Special reference to therapeutic approaches Journal of Hepato-Biliary-Pancreatic Sciences . 2021.01; 28 (1): 62-75. ( PubMed , DOI )

  22. Kikuko Amo-Shiinoki, Katsuya Tanabe, Yoshinobu Hoshii, Hiroto Matsui, Risa Harano, Tatsuya Fukuda, Takato Takeuchi, Ryotaro Bouchi, Tokiyo Takagi, Masayuki Hatanaka, Komei Takeda, Shigeru Okuya, Wataru Nishimura, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe, Takumi Akashi, Tetsuya Yamada, Yoshihiro Ogawa, Eiji Ikeda, Hiroaki Nagano, Yukio Tanizawa: Islet cell dedifferentiation is a pathologic mechanism of long-standing progression of type 2 diabetes. JCI Insight. 2021.01; 6 (1): ( PubMed , DOI )

  1. Murase Y, Ban D, Maekawa A, Watanabe S, Ishikawa Y, Akahoshi K, Ogawa K, Ono H, Kudo A, Kudo T, Tanaka S, Tanabe M: Successful conversion surgery of distal pancreatectomy with celiac axis resection (DP-CAR) with double arterial reconstruction using saphenous vein grafting for locally advanced pancreatic cancer: a case report. Surgical case reports. 2020.12; 6 (1): 302. ( PubMed , DOI )

  2. Seol HS, Akiyama Y, Lee SE, Shimada S, Jang SJ.: Loss of miR-100 and miR-125b results in cancer stem cell properties through IGF2 upregulation in hepatocellular carcinoma. Scientific Reports.. 2020.12; 10 (1): 21412. ( DOI )

  3. Yoshiki Murase, Daisuke Ban, Aya Maekawa, Shuichi Watanabe, Yoshiya Ishikawa, Keiichi Akahoshi, Kosuke Ogawa, Hiroaki Ono, Atsushi Kudo, Toshifumi Kudo, Shinji Tanaka, Minoru Tanabe: Successful conversion　surgery　of　distal　pancreatectomy　with　celiac　axis　resection(DP-CAR)　with　double　arterial　reconstruction using saphenous vein grafting for locally advanced pancreatic cancer: a case report Surgical Case Reports. 2020.12;

  4. Kimura Koichiro, Tsuchiya Junichi, Kitazume Yoshio, Kishino Mitsuhiro, Akahoshi Keiichi, Kudo Atsushi, Tanaka Shinji, Tanabe Minoru, Tateishi Ukihide: Dynamic Enhancement Pattern on CT for Predicting Pancreatic Neuroendocrine Neoplasms with Low PAX6 Expression: A Retrospective Observational Study. Diagnostics (Basel). 2020.11; 10 (11): ( PubMed , DOI )

  5. Koichiro Kimura, Junichi Tsuchiya, Yoshio Kitazume, Mitsuhiro Kishino, Keiichi Akahoshi, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe, Ukihide Tateishi : Dynamic Enhancement Pattern on CT for Predicting Pancreatic Neuroendocrine Neoplasms with Low PAX6 Expression: A Retrospective Observational Study Diagnostics . 2020.11; 10 (11): 919.

  6. 島田 周, 秋山 好光, 田邉 稔, 田中 真二: KDM6A発現低下を特徴とする膵がん予後不良サブタイプにはHDAC阻害剤が著効する 日本癌学会総会記事. 2020.10; 79回 OJ14-6. ( ichushi )

  7. Asano, Daisuke, Kudo, Atsushi, Akahoshi, Keiichi, Maekawa, Aya, Murase, Yoshiki, Ogawa, Kosuke, Ono, Hiroaki, Ban, Daisuke, Tanaka, Shinji, Tanabe, Minoru : Curative Surgery and Ki-67 Value Rather than Tumor Differentiation Predict the Survival of Patients with High-grade Neuroendocrine Neoplasms Annals of Surgery . 2020.09;

  8. Asano D, Kudo A, Akahoshi K, Maekawa A, Murase Y, Ogawa K, Ono H, Ban D, Tanaka S, Tanabe M: Curative Surgery and Ki-67 Value Rather than Tumor Differentiation Predict the Survival of Patients with High-grade Neuroendocrine Neoplasms. Annals of surgery. 2020.09; ( PubMed , DOI )

  9. Yoshino J, Akiyama Y, Shimada S, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Yamaoka S, Tanabe M, Tanaka S: Loss of ARID1A induces a stemness gene ALDH1A1 expression with histone acetylation in the malignant subtype of cholangiocarcinoma. Carcinogenesis. 2020.07; 41 (6): 734-742. ( PubMed , DOI )

  10. Matsui Satoshi, Ogura Toshiro, Ban Daisuke, Ogawa Kosuke, Ono Hiroaki, Mitsunori Yusuke, Kudo Atsushi, Tanaka Shinji, Tanabe Minoru: Position of the Pancreas Division Line and Postoperative Outcomes After Distal Pancreatectomy WORLD JOURNAL OF SURGERY. 2020.04; 44 (4): 1244-1251. ( PubMed , DOI )

  11. Fujita M, Yamaguchi R, Hasegawa T, Shimada S, Arihiro K, Hayashi S, Maejima K, Nakano K, Fujimoto A, Ono A, Aikata H, Ueno M, Hayami S, Tanaka H, Miyano S, Yamaue H, Chayama K, Kakimi K, Tanaka S, Imoto S, Nakagawa H: Classification of primary liver cancer with immunosuppression mechanisms and correlation with genomic alterations. EBioMedicine. 2020.03; 53 102659. ( PubMed , DOI )

  12. Hiroaki Ono, Atsushi Kudo, Keiichi Akahoshi, Toshiro Ogura, Kosuke Ogawa, Daisuke Ban, Shinji Tanaka, Minoru Tanabe: Combination of weekly streptozocin and oral S-1 treatment for patients of unresectable or metastatic pancreatic neuroendocrine neoplasms Journal of Cancer Research and Clinical Oncology. 2020.03; 146 (3): 793-799.

  13. Ono Hiroaki, Kudo Atsushi, Akahoshi Keiichi, Ogura Toshiro, Ogawa Kosuke, Ban Daisuke, Tanaka Shinji, Tanabe Minoru: Combination of weekly streptozocin and oral S-1 treatment for patients of unresectable or metastatic pancreatic neuroendocrine neoplasms JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. 2020.03; 146 (3): 793-799. ( PubMed , DOI )

  14. Ono S, Dohi O, Yagi N, Sanomura Y, Tanaka S, Naito Y, Sakamoto N, Kato M: Accuracies of Endoscopic Diagnosis of Helicobacter pylori-Gastritis: Multicenter Prospective Study Using White Light Imaging and Linked Color Imaging. Digestion. 2020; 101 (5): 624-630. ( PubMed , DOI )

  1. Asakawa M, Itoh M, Suganami T, Sakai T, Kanai S, Shirakawa I, Yuan X, Hatayama T, Shimada S, Akiyama Y, Fujiu K, Inagaki Y, Manabe I, Yamaoka S, Yamada T, Tanaka S, Ogawa Y: Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis. Scientific reports. 2019.12; 9 (1): 19601. ( PubMed , DOI )

  2. Ono Hiroaki, Ikeda Sadakatsu, Ogawa Kosuke, Ogura Toshiro, Ban Daisuke, Kudo Atushi, Miyake Satoshi, Tanaka Shinji, Tanabe Minoru: Genomic sequencing in HBP malignancies(和訳中) 日本消化器病学会雑誌. 2019.11; 116 (臨増大会): A893. ( ichushi )

  3. Ono Hiroaki, Ikeda Sadakatsu, Ogawa Kosuke, Ogura Toshiro, Ban Daisuke, Kudo Atushi, Miyake Satoshi, Tanaka Shinji, Tanabe Minoru: HBP悪性疾患に関するゲノムシークエンス解析(Genomic sequencing in HBP malignancies) 日本消化器外科学会雑誌. 2019.11; 52 (Suppl.2): 306. ( ichushi )

  4. Matsui S, Ogura T, Ban D, Ogawa K, Ono H, Mitsunori Y, Kudo A, Tanaka S, Tanabe M.: Position of the Pancreas Division Line and Postoperative Outcomes After Distal Pancreatectomy. World Journal of Surgery. 2019.11;

  5. Qian Yamin, Wu Xin, Yokoyama Yuhki, Okuzaki Daisuke, Taguchi Mai, Hirose Haruka, Wang Jiaqi, Hata Tsuyoshi, Inoue Akira, Hiraki Masayuki, Ohtsuka Masahisa, Takahashi Hidekazu, Haraguchi Naotsugu, Mizushima Tsunekazu, Tanaka Shinji, Mori Masaki, Yamamoto Hirofumi: E-cadherin-Fc chimera protein matrix enhances cancer stem-like properties and induces mesenchymal features in colon cancer cells CANCER SCIENCE. 2019.11; 110 (11): 3520-3532. ( PubMed , DOI )

  6. Qian Yamin, Wu Xin, Yokoyama Yuhki, Okuzaki Daisuke, Taguchi Mai, Hirose Haruka, Wang Jiaqi, Hata Tsuyoshi, Inoue Akira, Hiraki Masayuki, Ohtsuka Masahisa, Takahashi Hidekazu, Haraguchi Naotsugu, Mizushima Tsunekazu, Tanaka Shinji, Mori Masaki, Yamamoto Hirofumi: E-カドヘリン-Fcキメラ蛋白質マトリックスは、癌幹細胞の特性を増強し、結腸癌細胞の間葉系特性を誘導する(E-cadherin-Fc chimera protein matrix enhances cancer stem-like properties and induces mesenchymal features in colon cancer cells) Cancer Science. 2019.11; 110 (11): 3520-3532. ( ichushi )

  7. Yoshino J, Akiyama Y, Shimada S, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Yamaoka S, Tanabe M, Tanaka S.: Loss of ARID1A induces a stemness gene ALDH1A1 expression with histone acetylation in the malignant subtype of cholangiocarcinoma. Carcinogenesis. 2019.10;

  8. Liu Bo, Kudo Atsushi, Kinowaki Yuko, Ogura Toshiro, Ogawa Kosuke, Ono Hiroaki, Mitsunori Yusuke, Ban Daisuke, Tanaka Shinji, Akashi Takumi, Tanabe Minoru: A simple and practical index predicting the prognoses of the patients with well-differentiated pancreatic neuroendocrine neoplasms JOURNAL OF GASTROENTEROLOGY. 2019.09; 54 (9): 819-828. ( PubMed , DOI )

  9. Liu B, Kudo A, Kinowaki Y, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Tanaka S, Akashi T, Tanabe M: A simple and practical index predicting the prognoses of the patients with well-differentiated pancreatic neuroendocrine neoplasms The Japanese Society of Gastroenterology. 2019.09; 54 (9): 819-828.

  10. Jun Yoshino, Daisuke Ban, Toshiro Ogura, Kosuke Ogawa, Hiroaki Ono, Yusuke Mitsunori, Atsushi Kudo, Shinji Tanaka & Minoru Tanabe: The Clinial Implications of Peripancreatic Fluid Collection After Distal Pancreatectomy World Journal of Surgery. 2019.08; 43 (8): 2069-2076.

  11. Yoshino Jun, Ban Daisuke, Ogura Toshiro, Ogawa Kosuke, Ono Hiroaki, Mitsunori Yusuke, Kudo Atsushi, Tanaka Shinji, Tanabe Minoru: The Clinical Implications of Peripancreatic Fluid Collection After Distal Pancreatectomy WORLD JOURNAL OF SURGERY. 2019.08; 43 (8): 2069-2076. ( PubMed , DOI )

  12. Matsui Satoshi, Kudo Atsushi, Ogura Toshiro, Ogawa Kosuke, Ono Hiroaki, Mitsunori Yusuke, Ban Daisuke, Tanaka Shinji, Tanabe Minoru: Does sunitinib have a patient-specific dose without diminishing its antitumor effect on advanced pancreatic neuroendocrine neoplasms? JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. 2019.08; 145 (8): 2097-2104. ( PubMed , DOI )

  13. Matsui S, Kudo A, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Tanaka S, Tanabe M.: Does sunitinib have a patient-specific dose without diminishing its antitumor effect on advanced pancreatic neuroendocrine neoplasms? Journal of Cancer Research and Clinical Oncology. 2019.08; 145 (8): 2097-2104.

  14. Shimada S, Tanaka S: A new era for understanding genetic evolution of multistep carcinogenesis. Journal of gastroenterology. 2019.07; 54 (7): 667-668. ( PubMed , DOI )

  15. Shuichi Watanabe, Shu Shimada, Yoshimitsu Akiyama, Yoshiya Ishikawa, Toshiro Ogura, Kosuke Ogawa, Hiroaki Ono, Yusuke Mitsunori, Daisuke Ban, Atsushi Kudo, Shoji Yamaoka, Minoru Tanabe, Shinji Tanaka: Loss of KDM6A characterizes a poor prognostic subtype of human pancreatic cancer and potentiates HDAC inhibitor lethality. Int. J. Cancer. 2019.07; 145 (1): 192-205. ( PubMed , DOI )

  16. Shimada Shu, Tanaka Shinji: 多段階発癌の遺伝的進化の理解の新時代(A new era for understanding genetic evolution of multistep carcinogenesis) Journal of Gastroenterology. 2019.07; 54 (7): 667-668. ( ichushi )

  17. Akahoshi Keiichi, Ban Daisuke, Kuboki Ryo, Oba Atsushi, Ono Hiroaki, Mitsunori Yusuke, Kudo Atsushi, Tanaka Shinji, Tanabe Minoru: Orotate phosphoribosyltransferase as a predictor of benefit from S-1 adjuvant chemotherapy for cholangiocarcinoma patients JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. 2019.06; 34 (6): 1108-1115. ( PubMed , DOI )

  18. Ban Daisuke, Kudo Atsushi, Tanaka Shinji, Tanabe Minoru: HBP外科専門医への教育ロードマップ　腹腔鏡下HBP外科専門医へのロードマップ(Education roadmap to qualified HBP surgeons　Roadmap to the qualified laparoscopic HBP surgeon) 日本肝胆膵外科学会・学術集会プログラム・抄録集. 2019.06; 31回 ESY1-1. ( ichushi )

  19. Keisuke Okuno, Yoshimitsu Akiyama, Shu Shimada, Masatoshi Nakagawa, Toshiro Tanioka, Mikito Inokuchi, Shoji Yamaoka, Kazuyuki Kojima, Shinji Tanaka: Asymmetric dimethylation at histone H3 arginine 2 by PRMT6 in gastric cancer progression. Carcinogenesis. 2019.03; 40 (1): 15-26. ( PubMed , DOI )

  20. Hiroshi Fukamachi, Seon-Kyu Kim, Jiwon Koh, Hye Seung Lee, Yasushi Sasaki, Kentaro Yamashita, Taketo Nishikawaji, Shu Shimada, Yoshimitsu Akiyama, Sun-Ju Byeon, Dong-Hyuck Bae, Keisuke Okuno, Masatoshi Nakagawa, Toshiro Tanioka, Mikito Inokuchi, Hiroshi Kawachi, Kiichiro Tsuchiya, Kazuyuki Kojima, Takashi Tokino, Yoshinobu Eishi, Yong Sung Kim, Woo Ho Kim, Yasuhito Yuasa, Shinji Tanaka: A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors. J. Exp. Clin. Cancer Res.. 2019.03; 38 (1): 127. ( PubMed , DOI )

  21. Shu Shimada, Kaoru Mogushi, Yoshimitsu Akiyama, Takaki Furuyama, Shuichi Watanabe, Toshiro Ogura, Kosuke Ogawa, Hiroaki Ono, Yusuke Mitsunori, Daisuke Ban, Atsushi Kudo, Shigeki Arii, Minoru Tanabe, Jack R Wands, Shinji Tanaka: Comprehensive molecular and immunological characterization of hepatocellular carcinoma. EBioMedicine. 2019.02; 40 457-470. ( PubMed , DOI )

  22. Ishikawa Y, Ban D, Watanabe S, Akahoshi K, Ono H, Mitsunori Y, Kudo A, Tanaka S, Tanabe M: Splenic artery as a simple landmark indicating difficulty during laparoscopic distal pancreatectomy. Asian journal of endoscopic surgery. 2019.01; 12 (1): 81-87. ( PubMed , DOI )

  1. Tanaka Shinji: Molecular target therapy for liver cancer under precision medicine CANCER SCIENCE. 2018.12; 109 634.

  2. Watanabe Yuichiro, Honda Shinya, Konishi Akimitsu, Tanabe Minoru, Tanaka Shinji, Shimizu Shigeomi: Autophagy controls centrosome number by degrading Cep63 CANCER SCIENCE. 2018.12; 109 309.

  3. Akiyama Yoshimitsu, Shimada Shu, Tanabe Minoru, Tanaka Shinji: DAXX acts as a tumor suppressor through histone H3.3/H3K9me3 pathway in pancreatic neuroendocrine tumors CANCER SCIENCE. 2018.12; 109 1103.

  4. Mizuno Yuki, Shimada Shu, Akiyama Yoshimitsu, Watanabe Shuichi, Aida Tomomi, Ogawa Kosuske, Ono Hiroaki, Mitsunori Yusuke, Ban Daisuke, Kudo Atsushi, Yamaoka Shoji, Tanaka Shinji, Tanabe Minoru: DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma CANCER SCIENCE. 2018.12; 109 952.

  5. Fukamachi Hiroshi, Nishikawaji Taketo, Shimada Shu, Akiyama Yoshimitsu, Yuasa Yasuhito, Tsuchiya Kiichiro, Tanaka Shinji: Diffuse-type gastric cancers are classified into two clusters, which may be formed via different carcinogenic pathways CANCER SCIENCE. 2018.12; 109 1131.

  6. Shimada Shu, Akiyama Yoshimitsu, Tanabe Minoru, Tanaka Shinji: FABP4 overexpression in intratumoral hepatic stellate cells within hepatocellular carcinoma with metabolic risk factors CANCER SCIENCE. 2018.12; 109 940.

  7. Akahoshi Keiichi, Ono Hiroaki, Akasu Masafumi, Ban Daisuke, Kudo Atsushi, Konta Atsuko, Tanaka Shinji, Tanabe Minoru: Rapid growth speed of cysts can predict malignant intraductal mucinous papillary neoplasms JOURNAL OF SURGICAL RESEARCH. 2018.11; 231 195-200. ( PubMed , DOI )

  8. Keiichi Akahoshi, Hiroaki Ono, Masafumi Akasu, Daisuke Ban, Atsushi Kudo, Atsuko Konta, Shinji Tanaka, Minoru Tanabe: Rapid growth speed of cysts can predict malignant intraductal mucinous papillary neoplasms Journal of Surgical Research. 2018.11; 231 195-200.

  9. Keiichi Akahoshi, Daisuke Ban, Ryo Kuboki, Atsushi Oba, Hiroaki Ono, Yusuke Mitsunori, Atsushi Kudo, Shinji Tanaka and Minoru Tanabe: Orotate phosphoribosyltransferase as a predictor of benefit from S-1 adjuvant chemotherapy for cholangiocarcinoma patients Journal of Gastroenterology and Hepatology. 2018.09;

  10. Atsushi Kudo, Keiichi Akahoshi, Sakiko Ito, Takumi Akashi, Shu Shimada, Toshiro Ogura, Kosuke Ogawa, Hiroaki Ono, Yusuke Mitsunori, Daisuke Ban, Ukihide Tateishi, Shinji Tanaka, Minoru Tanabe: Downregulated Pancreatic Beta Cell Genes Indicate Poor Prognosis in Patients With Pancreatic Neuroendocrine Neoplasms. Ann. Surg.. 2018.07; ( PubMed , DOI )

  11. Kudo A, Akahoshi K, Ito S, Akashi T, Shimada S, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Tateishi U, Tanaka S, Tanabe M: Downregulated Pancreatic Beta Cell Genes Indicate Poor Prognosis in Patients With Pancreatic Neuroendocrine Neoplasms. Annals of Surgery. 2018.07;

  12. Yuki Mizuno, Atsushi Kudo, Takumi Akashi, Keiichi Akahoshi, Toshiro Ogura, Kosuke Ogawa, Hiroaki Ono, Yusuke Mitsunori, Daisuke Ban, Shinji Tanaka, Ukihide Tateishi, Minoru Tanabe: Sunitinib shrinks NET-G3 pancreatic neuroendocrine neoplasms. J. Cancer Res. Clin. Oncol.. 2018.06; 144 (6): 1155-1163. ( PubMed , DOI )

  13. Ueda Hiroki, Akiyama Yoshimitsu, Shimada Shu, Mogushi Kaoru, Serizawa Misaki, Matsumura Satoshi, Mitsunori Yusuke, Aihara Arihiro, Ban Daisuke, Ochiai Takanori, Kudo Atsushi, Tanabe Minoru, Tanaka Shinji: Tumor suppressor functions of DAXX through histone H3.3/H3K9me3 pathway in pancreatic NETs ENDOCRINE-RELATED CANCER. 2018.06; 25 (6): 619-631. ( PubMed , DOI )

  14. Chiyonobu Norimichi, Shimada Shu, Akiyama Yoshimitsu, Mogushi Kaoru, Itoh Michiko, Akahoshi Keiichi, Matsumura Satoshi, Ogawa Kosuke, Ono Hiroaki, Mitsunori Yusuke, Ban Daisuke, Kudo Atsushi, Arii Shigeki, Suganami Takayoshi, Yamaoka Shoji, Ogawa Yoshihiro, Tanabe Minoru, Tanaka Shinji: Fatty Acid Binding Protein 4 (FABP4) Overexpression in Intratumoral Hepatic Stellate Cells within Hepatocellular Carcinoma with Metabolic Risk Factors AMERICAN JOURNAL OF PATHOLOGY. 2018.05; 188 (5): 1213-1224. ( PubMed , DOI )

  15. Norimichi Chiyonobu, Shu Shimada, Yoshimitsu Akiyama, Kaoru Mogushi, Michiko Itoh, Keiichi Akahoshi, Satoshi Matsumura, Kosuke Ogawa, Hiroaki Ono, Yusuke Mitsunori, Daisuke Ban, Atsushi Kudo, Shigeki Arii, Takayoshi Suganami, Shoji Yamaoka, Yoshihiro Ogawa, Minoru Tanabe, Shinji Tanaka: Fatty acid binding protein 4 (FABP4) overexpression in intratumoral hepatic stellate cells within hepatocellular carcinoma with metabolic risk factors The American Journal of Pathology. 2018.05; 188 (5):

  16. Shu Shimada, Yoshimitsu Akiyama, Kaoru Mogushi, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiromi Nagasaki, Hiroshi Fukamachi, Yasuhito Yuasa, Shinji Tanaka: Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models. Br. J. Cancer. 2018.04; 118 (7): 972-984. ( PubMed , DOI )

  17. Kawai-Kitahata F., Asahina Y., Kakinuma S., Murakawa M., Nitta S., Nagata H., Kaneko S., Inoue E., Miyoshi M., Tsunoda T., Sato A., Nakagawa M., Itsui Y., Azuma S., Tanaka S., Tanabe M., Maekawa S., Enomoto N., Watanabe M.: Difference of gene mutational profile among viral- and non-viral HCC with or without prior HBV infection: Results of comprehensive deep sequencing analyses of cancer genes and HBV/AAV integration JOURNAL OF HEPATOLOGY. 2018.04; 68 S667.

  18. Tanaka Shinji: ゲノム規模解析およびゲノム編集技術の時代に外科腫瘍学に基づいた精密医療(Precision medicine based on surgical oncology in the era of genome-scale analysis and genome editing technology) Annals of Gastroenterological Surgery. 2018.03; 2 (2): 106-115. ( ichushi )

  19. Yuki Mizuno,Atsushi Kudo,Takumi Akashi,Toshiro Ogura,Kosuke Ogawa,Hiroaki Ono, Yusuke Mitsunori,Daisuke Ban, Shinji Tanaka, Ukihide Tateishi, Minoru Tanabe: Sunitinib shrinks NET-G3 pancreatic neuroendocrine neoplasms Journal of Cancer Research and Clinical Oncology. 2018.03; 144 1155-1163.

  20. Ueda H, Akiyama Y, Shimada S, Mogushi K, Serizawa M, Matsumura S, Mitsunori Y, Aihara A, Ban D, Ochiai T, Kudo A, Tanabe M, Tanaka S: Tumor suppressor functions of DAXX through histone H3.3/H3K9me3 pathway in pancreatic NETs. Endocrine-Related Cancer. 2018.03; 25 (6): 619-631.

  21. Tanaka Shinji: HCCと膵癌に対するオーダーメイド医療(Precision medicine for HCC and pancreatic cancer) 日本消化器病学会雑誌. 2018.03; 115 (臨増総会): A200. ( ichushi )

  22. Yoshiya Ishikawa, Daisuke Ban, Shuichi Watanabe, Keiichi Akahoshi, Hiroaki Ono, Yusuke Mitsunori, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe: Splenic artery as a simple landmark indicating difficulty during laparoscopic distal pancreatectomy Asian Journal of Endoscopic Surgery. 2018.02; 1-7.

  23. Akiyama Yoshimitsu, Nishikawaji Taketo, Shimada Shu, Yuasa Yasuhito, Tanaka Shinji: Molecular mechanisms of SETDB2 histone methyltransferase overexpression in gastric cancer CANCER SCIENCE. 2018.01; 109 913.

  24. Mizuno Y, Shimada S, Akiyama Y, Watanabe S, Aida T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Arii S, Yamaoka S, Tanabe M, Tanaka S: DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma. Scientific　Reports. 2018.01; 8 (1):

  25. Mizuno Yuki, Shimada Shu, Akiyama Yoshimitsu, Watanabe Shuichi, Aida Tomomi, Ogawa Kosuke, Ono Hiroaki, Mitsunori Yusuke, Ban Daisuke, Kudo Atsushi, Arii Shigeki, Yamaoka Shoji, Tanabe Minoru, Tanaka Shinji: DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma SCIENTIFIC REPORTS. 2018.01; 8 (1): 106. ( PubMed , DOI )

  26. Shimada Shu, Akiyama Yoshimitsu, Tanaka Shinji: Acquired resistance with epigenetic alterations under long-term anti-angiogenic therapy for hepatocellular carcinoma CANCER SCIENCE. 2018.01; 109 60.

  27. Fukamachi Hiroshi, Nishikawaji Taketo, Shimada Shu, Akiyama Yoshimitsu, Yuasa Yasuhito, Tuchiya Kiichiro, Tanaka Shinji: Identification of signal transduction pathway in PDX-derived diffuse-type gastric tumor-initiating cells CANCER SCIENCE. 2018.01; 109 880.

  28. Oba Atsushi, Ban Daisuke, Kudo Atsushi, Kirimura Susumu, Ito Hiromitsu, Matsumura Satoshi, Mitsunori Yusuke, Aihara Arihiro, Ochiai Takanori, Tanaka Shinji, Tanabe Minoru: Correlation Between the Acquisition of Resistance to Gemcitabine Therapy and the Expression of HuR in Pancreatic Ductal Adenocarcinoma: A Case Report INTERNATIONAL SURGERY. 2018; 103 (1-2): 116-120. ( DOI )

  1. Ueda H, Ban D, Akahoshi K, Mitsunori Y, Matsumura S, Ochiai T, Kudo A, Tanaka S, Tanabe M: Refractory long-term cholangitis after pancreaticoduodenectomy: a retrospective study. World Journal of Surgery. 2017.07; 41 (7): 1882-1889. ( DOI )

  2. Ishikawa Yoshiya, Ban Daisuke, Matsumura Satoshi, Mitsunori Yusuke, Ochiai Takanori, Kudo Atsushi, Tanaka Shinji, Tanabe Minoru: Surgical pitfalls of jejunal vein anatomy in pancreaticoduodenectomy JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES. 2017.07; 24 (7): 394-400. ( PubMed , DOI )

  3. Ueda Hiroki, Ban Daisuke, Kudo Atsushi, Ochiai Takanori, Tanaka Shinji, Tanabe Minoru: Refractory Long-Term Cholangitis After Pancreaticoduodenectomy: A Retrospective Study WORLD JOURNAL OF SURGERY. 2017.07; 41 (7): 1882-1889. ( PubMed , DOI )

  4. Ishikawa Y, Ban D, Matsumura S, Mitsunori Y, Ochiai T, Kudo A, Tanaka S, Tanabe M: Surgical pitfalls of jejunal vein anatomy in pancreaticoduodenectomy. J Hepatobiliary Pancreat Sci. 2017.07; 4 (7): 394-400. ( DOI )

  5. Ohata Y, Shimada S, Akiyama Y, Mogushi K, Ito H, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Tanabe M, Tanaka S : Acquired resistance with epigenetic alterations under long-term anti-angiogenic therapy for hepatocellular carcinoma. Molecular Cancer Therapeutics. 2017.06; 16 (6): 1155-1165. ( DOI )

  6. Ohata Yoshiteru, Shimada Shu, Akiyama Yoshimitsu, Mogushi Kaoru, Nakao Keisuke, Matsumura Satoshi, Aihara Arihiro, Mitsunori Yusuke, Ban Daisuke, Ochiai Takanori, Kudo Atsushi, Arii Shigeki, Tanabe Minoru, Tanaka Shinji: Acquired Resistance with Epigenetic Alterations Under Long-Term Antiangiogenic Therapy for Hepatocellular Carcinoma MOLECULAR CANCER THERAPEUTICS. 2017.06; 16 (6): 1155-1165. ( PubMed , DOI )

  7. Atsushi Oba, Atsushi Kudo, Keiichi Akahoshi, Mitsuhiro Kishino, Takumi Akashi, Eriko Katsuta, Yasuhito Iwao, Hiroaki Ono, Yusuke Mitsunori, Daisuke Ban, Shinji Tanaka, Yoshinobu Eishi, Ukihide Tateishi, Minoru Tanabe: A simple morphological classification to estimate the malignant potential of pancreatic neuroendocrine tumors. J. Gastroenterol.. 2017.05; 52 (10): 1140-1146. ( PubMed , DOI )

  8. Oba A, Shimada S, Akiyama Y, Nishikawaji T, Mogushi K, Ito H, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Asahara H, Kaida A, Miura M, Tanabe M, Tanaka S : ARID2 modulates DNA damage response in human hepatocellular carcinoma cells. Journal of Hepatology. 2017.05; 66 (5): 942-951. ( DOI )

  9. Chiyonobu Norimichi, Ono Hiroaki, Iwao Yasuhito, Matsumura Satoshi, Mitsunori Yusuke, Ban Daisuke, Ochiai Takanori, Kudo Atsushi, Tanaka Shinji, Tanabe Minoru: IPMNの術前画像検査において造影される結節の臨床的意義(Clinical significance of enhancing nodules in preoperative imaging studies of IPMN) Journal of Hepato-Biliary-Pancreatic Sciences. 2017.05; 24 (Suppl.1): A369. ( ichushi )

  10. Keiichi Akahoshi, Takanori Ochiai, Ayumi Takaoka, Takuya Kitamura, Daisuke Ban, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe: Emergency Cholecystectomy for Patients on Antiplatelet Therapy. Am Surg. 2017.05; 83 (5): 486-490. ( PubMed )

  11. Ono Hiroaki, Akahoshi Keiichi, Iwao Yasuhito, Matsumura Satoshi, Mitsunori Yuusuke, Ban Daisuke, Ochiai Takanori, Kudo Atsushi, Tanaka Shinji, Tanabe Minoru: IPMNに対する手術後におけるリンパ節転移の臨床評価(Clinical evaluation of lymph node metastasis after surgery of IPMN) Journal of Hepato-Biliary-Pancreatic Sciences. 2017.05; 24 (Suppl.1): A115. ( ichushi )

  12. Akahoshi Keiichi, Ochiai Takanori, Takaoka Ayumi, Kitamura Takuya, Ban Daisuke, Kudo Atsushi, Tanaka Shinji, Tanabe Minoru: Emergency Cholecystectomy for Patients on Antiplatelet Therapy AMERICAN SURGEON. 2017.05; 83 (5): 486-490.

  13. Ban Daisuke, Asano Daisuke, Akahoshi Keiichi, Ono Hiroaki, Mitsunori Yusuke, Kudo Atsushi, Tanaka Shinji, Tanabe Minoru: Borderline resectable膵癌に対するCT画像の特徴に応じた至適管理(The optimal management depending on the features of CT imaging of borderline resectable pancreatic cancer) Journal of Hepato-Biliary-Pancreatic Sciences. 2017.05; 24 (Suppl.1): A165. ( ichushi )

  14. 田中 真二, 島田 周, 秋山 好光, 松村 聡, 光法 雄介, 藍原 有弘, 落合 高徳, 伴 大輔, 工藤 篤, 有井 滋樹, 田邉 稔: Precision medicine　bench to bedside　肝胆膵がんの分子サブタイプと治療抵抗性解析によるprecision medicineの展開 日本外科学会定期学術集会抄録集. 2017.04; 117回 SY-7. ( ichushi )

  15. Oze I, Shimada S, Nagasaki H, Akiyama Y, Watanabe M, Yatabe Y, Matsuo K, Yuasa Y.: Plasma miR-103, miR-107, and miR-194 levels are not correlated with human diffuse gastric cancer. Journal of Cancer Research and Clinical Oncology. 2017.03; (143): 551-554.

  16. Oze I, Shimada S, Nagasaki H, Akiyama Y, Watanabe M, Yatabe Y, Matsuo K, Yuasa Y: Plasma microRNA-103, microRNA-107, and microRNA-194 levels are not biomarkers for human diffuse gastric cancer. Journal of Cancer Research and Clinical Oncology. 2017.03; 143 (3): 551-554. ( PubMed , DOI )

  17. Kawai-Kitahata F., Asahina Y., Kakinuma S., Murakawa M., Nitta S., Nagata H., Kaneko S., Otani S., Asano Y., Inoue E., Miyoshi M., Tsunoda T., Sato A., Nakagawa M., Itsui Y., Azuma S., Tanaka S., Tanabe M., Maekawa S., Enomoto N., Watanabe M.: Genetic differences in hepatocellular carcinoma among chronic persistent hepatitis B virus infection with or without viral suppression and prior hepatitis B virus infection JOURNAL OF HEPATOLOGY. 2017; 66 (1): S227.

  1. Furuyama T, Kudo A, Matsumura S, Mitsunori Y, Aihara A, Ban D, Ochiai T, Tanaka S, Tanabe M: Preoperative direct bilirubin to prothrombin time ratio index to prevent liver failure after minor hepatectomy J Hepatobiliary Pancreat Sci. 2016.12; 23 (12): 763-770. ( DOI )

  2. Watanabe Y, Honda S, Konishi A, Satoko Arakawa S, Murohashi M, Yamaguchi H, Torii S, Tanabe M, Tanaka S, Warabi E, Shimizu S: Autophagy controls centrosome number by degrading Cep63. Nature Communications. 2016.11; 21 (7): 13508. ( DOI )

  3. Munakata K, Uemura M, Tanaka S, Kawai K, Kitahara T, Miyo M, Kano Y, Nishikawa S, Fukusumi T, Takahashi Y, Hata T, Nishimura J, Takemasa I, Mizushima T, Ikenaga M, Kato T, Murata K, Carethers JM, Yamamoto H, Doki Y, Mori M: Cancer stem-like properties in colorectal cancer cells with low proteasome activity Clinical Cancer Research. 2016.11; 22 (21): 5277-5286.

  4. Angel Diaz-Lagares, Ana B Crujeiras, Paula Lopez-Serra, Marta Soler, Fernando Setien, Ashish Goyal, Juan Sandoval, Yutaka Hashimoto, Anna Martinez-Cardús, Antonio Gomez, Holger Heyn, Catia Moutinho, Jesús Espada, August Vidal, Maria Paúles, Maica Galán, Núria Sala, Yoshimitsu Akiyama, María Martínez-Iniesta, Lourdes Farré, Alberto Villanueva, Matthias Gross, Sven Diederichs, Sonia Guil, Manel Esteller: Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer. Proc. Natl. Acad. Sci. U.S.A.. 2016.11; 113 (47): E7535-E7544.

  5. Nishikawaji T, Akiyama Y, Shimada S, Kojima K, Kawano T, Eishi Y, Yuasa Y, Tanaka S: Oncogenic roles of the SETDB2 histone methyltransferase in gastric cancer. Oncotarget. 2016.10; 7 (41): 67251-67265. ( PubMed , DOI )

  6. Nishikawaji T, Akiyama Y, Shimada S, Kojima K, Kawano T, Eishi Y, Yuasa Y, Tanaka S: Overexpression of histone methyltransferase SETDB2 acts an oncogene in gastric cancer Oncotarget. 2016.10; 7 (41): 67251-67265. ( DOI )

  7. Akahoshi K, Tanaka S, Mogushi K, Shimada S, Matsumura S, Akiyama Y, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Arii S, Tanabe M: Expression of connective tissue growth factor in the livers of non-viral hepatocellular carcinoma patients with metabolic risk factors Journal of Gastroenterology. 2016.09; 51 (9): 910-922. ( DOI )

  8. Akahoshi K, Tanaka S, Mogushi K, Shimada S, Matsumura S, Akiyama Y, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Arii S, Tanabe M.: Expression of connective tissue growth factor in the livers of non-viral hepatocellular carcinoma patients with metabolic risk factors. J Gastroenterol. . 2016.09; 51 (9): 910-922.

  9. Tanaka S: Cancer stem cells as therapeutic targets Human Stem Cell Toxicity (ed. Sherley JL). 2016.08; 280-294. ( DOI )

  10. Oba A, Ban D, Kirimura S, Akahoshi K, Mitsunori Y, Matsumura S, Ochiai T, Kudo A, Tanaka S, Tanabe M. : Clinical application of the biomarkers for the selection of adjuvant chemotherapy in pancreatic ductal adenocarcinoma. J Hepatobiliary Pancreat Sci. 2016.08; 23 (8): 480-488. ( DOI )

  11. Oba A, Ban D, Kirimura S, Akahoshi K, Mitsunori Y, Matsumura S, Ochiai T, Kudo A, Tanaka S, Minoru T.: Clinical application of the biomarkers for the selection of adjuvant chemotherapy in pancreatic ductal adenocarcinoma. J Hepatobiliary Pancreat Sci. . 2016.08; 23 (8): 480-488.

  12. Eriko Katsuta, Atsushi Kudo, Takumi Akashi, Yusuke Mitsunori, Satoshi Matsumura, Arihiro Aihara, Daisuke Ban, Takanori Ochiai, Shinji Tanaka, Yoshinobu Eishi, Minoru Tanabe: Macroscopic morphology for estimation of malignant potential in pancreatic neuroendocrine neoplasm. J. Cancer Res. Clin. Oncol.. 2016.06; 142 (6): 1299-1306. ( PubMed , DOI )

  13. Eriko Katsuta, Atsushi Kudo, Takumi Akashi, Yusuke Mitsunori, Satoshi Matsumura, Arihiro Aihara, Daisuke Ban, Takanori Ochiai, Shinji Tanaka, Yoshinobu Eishi, Minoru Tanabe: Macroscopic morphology for estimation of malignant potential in pancreatic neuroendocrine neoplasm J Cancer Res Clin Oncol . 2016.06; 142 1299-1306.

  14. Furuyama T, Tanaka S, Shimada S, Akiyama Y, Matsumura S, Mitsunori Y, Aihara A, Ban D, Ochiai T, Kudo A, Fukamachi H, Arii S, Kawaguchi Y, Tanabe M: Proteasome activity is required for the initiation of precancerous pancreatic lesions Scientific Reports. 2016.05; 6 27044. ( DOI )

  15. Furuyama T, Tanaka S, Shimada S, Akiyama Y, Matsumura S, Mitsunori Y, Aihara A, Ban D, Ochiai T, Kudo A, Fukamachi H, Arii S, Kawaguchi Y, Tanabe M: Proteasome activity is required for the initiation of precancerous pancreatic lesions. Sci Rep. 2016.05; 6 27044. ( PubMed , DOI )

  16. Yamada N, Yasui K, Dohi O, Gen Y, Tomie A, Kitaichi T, Iwai N, Mitsuyoshi H, Sumida Y, Moriguchi M, Yamaguchi K, Nishikawa T, Umemura A, Naito Y, Tanaka S, Arii S, Itoh Y: Genome-wide DNA methylation analysis in hepatocellular carcinoma Oncology Reports. 2016.04; 35 (4): 2228-2236. ( DOI )

  17. Lentjes MH, Niessen HE, Akiyama Y, de Bruïne AP, Melotte V, van Engeland M: The emerging role of GATA transcription factors in development and disease. Expert Rev Mol Med. 2016.03; 18 e3. ( PubMed , DOI )

  18. 4) Katsuta E, Tanaka S, Mogushi K, Shimada S, Akiyama Y, Aihara A, Matsumura S, Mitsunori Y, Ban D, Ochiai T, Kudo A, Fukamachi H, Tanaka H, Nakayama K, Arii S, Tanabe M : CD73 as a therapeutic target for pancreatic neuroendocrine tumor stem cells International Journal of Oncology. 2016.02; 48 (2): 657-669.

  19. Katsuta E, Tanaka S, Mogushi K, Shimada S, Akiyama Y, Aihara A, Matsumura S, Mitsunori Y, Ban D, Ochiai T, Kudo A, Fukamachi H, Tanaka H, Nakayama K, Arii S, Tanabe M.: CD73 as a therapeutic target for pancreatic neuroendocrine tumor stem cells. Int J Oncol. . 2016.02; 48 (2): 657-669.

  20. Tanaka S.: Molecular pathogenesis and targeted therapy of pancreatic cancer. Annals of Surgical Oncology. 2016.02; Suppl (2): 197-205.

  21. Ito H, Tanaka S, Akiyama Y, Shimada S, Adikrisna R, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Arii S, Yamaoka S, Tanabe M: Dominant Expression of DCLK1 in Human Pancreatic Cancer Stem Cells Accelerates Tumor Invasion and Metastasis. PLoS ONE. 2016.01; 11 (1): e0146564. ( PubMed , DOI )

  22. Akiyama Y, Koda Y, Byeon SJ, Shimada S, Nishikawaji T, Sakamoto A, Chen Y, Kojima K, Kawano T, Eishi Y, Deng D, Kim WH, Zhu WG, Yuasa Y, Tanaka S: Reduced expression of SET7/9, a histone mono-methyltransferase, is associated with gastric cancer progression. Oncotarget. 2016.01; 7 (4): 3966-3983. ( PubMed , DOI )

  1. Ayuna Sakamoto, Yoshimitsu Akiyama, Shu Shimada, Wei-Guo Zhu, Yasuhito Yuasa, Shinji Tanaka: DNA Methylation in the Exon 1 Region and Complex Regulation of Twist1 Expression in Gastric Cancer Cells. PLoS ONE. 2015.12; 10 (12): e0145630. ( PubMed , DOI )

  2. Fukiko Kawai-Kitahata, Yasuhiro Asahina, Shinji Tanaka, Sei Kakinuma, Miyako Murakawa, Sayuri Nitta, Takako Watanabe, Satoshi Otani, Miki Taniguchi, Fumio Goto, Hiroko Nagata, Shun Kaneko, Megumi Tasaka-Fujita, Yuki Nishimura-Sakurai, Seishin Azuma, Yasuhiro Itsui, Mina Nakagawa, Minoru Tanabe, Shinichi Takano, Mitsuharu Fukasawa, Minoru Sakamoto, Shinya Maekawa, Nobuyuki Enomoto, Mamoru Watanabe: Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features. J. Gastroenterol. 2015.11; ( PubMed , DOI )

  3. Hiroko Matsunaga, Shinji Tanaka, Arihiro Aihara, Kousuke Ogawa, Satoshi Matsumura, Daisuke Ban, Takanori Ochiai, Takumi Irie, Atsushi Kudo, Noriaki Nakamura, Shigeki Arii and Minoru Tanabe. : A Novel Therapeutic Combination Sequentially Targeting Aurora B and Bcl-xL in Hepatocellular Carcinoma. Ann. Surg. Oncol. 2015.09; 22 (9): 3079-3086.

  4. Watanabe Y, Yamamoto H, Oikawa R, Toyota M, Yamamoto M, Kokudo N, Tanaka S, Arii S, Yotsuyanagi H, Koike K, Itoh F: DNA methylation at hepatitis B viral integrants is associated with methylation at flanking human genomic sequences Genome Research. 2015; 25 (3): 328-337.

  5. Yasui K, Konishi C, Gen Y, Endo M, Dohi O, Tomie A, Kitaichi T, Yamada N, Iwai N, Nishikawa T, Yamaguchi K, Moriguchi M, Sumida Y, Mitsuyoshi H, Tanaka S, Arii S, Itoh Y: EVI1, a target gene for amplification at 3q26, antagonizes TGF-beta-mediated growth inhibition in hepatocellular carcinoma Cancer Science. 2015; 106 (7): 929-937.

  6. Ban D, Kudo A, Irie T, Ochiai T, Aihara A, Matusmura S, Tanaka S, Tanabe M: Advances in reduced port laparoscopic liver resection Asian Journal of Endoscopic Surgery. 2015; 8 (1): 11-15.

  7. Tanaka S: Cancer stem cells as therapeutic targets of hepato-biliary-pancreatic cancers Journal of Hepato-Biliary-Pancreatic Sciences. 2015; 22 (7): 531-537.

  8. Matsunaga H, Tanaka S, Aihara A, Ogawa K, Matsumura S, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Arii S, Tanabe M: A novel therapeutic combination targeting sequentially Aurora B and Bcl-xL in hepatocellular carcinoma Annals of Surgical Oncology. 2015; 22 (9): 3079-3086.

  9. Nakao K, Tanaka S, Miura T, Sato K, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Arii S, Tanabe M: A novel Aurora/VEGFR dual kinase inhibitor as treatment for hepatocellular carcinoma Cancer Science. 2015; 106 (8): 1016-1022.

  10. Sakamoto A, Akiyama Y, Shimada S, Zhu WG, Yuasa Y, Tanaka S: DNA methylation in the exon 1 region and complex regulation of Twist1 expression in gastric cancer PLoS ONE. 2015; 10 (12): e0145630.

  11. Miura T, Ban D, Tanaka S, Mogushi K, Kudo A, Matsumura S, Mitsunori Y, Ochiai T, Tanaka H, Tanabe M: Distinct clinicopathological phenotype of hepatocellular carcinoma with EOB-MRI hyperintensity: association with gene expression signature American Journal of Surgery. 2015; 210 (3): 561-569.

  12. Ban D, Kudo A, Ito H, Mitsunori Y, Matsumura S, Aihara A, Ochiai T, Tanaka S, Tanabe M, Itano O, Kaneko H, Wakabayashi G: The difficulty of laparoscopic liver resection Updates in Surgery. 2015; 67 (2): 123-128.

  13. Okajima C, Arii S, Tanaka S, Matsumura S, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Tanabe M: Prognostic role of Child-Pugh score 5 and 6 in hepatocellular carcinoma patients who underwent curative hepatic resection American Journal of Surgery. 2015; 209 (1): 199-205.

  1. Kudo A, Matusmura S, Ban D, Irie T, Ochiai T, Tanaka S, Arii S, Tanabe M.: Does the preoperative alpha-fetoprotein predict the recurrence and mortality after hepatectomy for hepatocellular carcinoma without macrovascular invasion in patients with normal liver function? Hepatol. Res.. 2014.12; 44 (14): E437-E446. ( PubMed , DOI )

  2. Seol HS, Akiyama Y, Shimada S, Lee HJ, Kim TI, Chun SM, Singh SR, Jang SJ: Epigenetic silencing of microRNA-373 to epithelial-mesenchymal transition in non-small cell lung cancer through IRAK2 and LAMP1 axes. Cancer Letters. 2014.10; 353 (2): 232-241. ( PubMed )

  3. Kudo A, Tanaka S, Ban D, Matsumura S, Irie T, Ochiai T, Nakamura N, Arii S, Tanabe M.: Alcohol consumption and recurrence of non-B or non-C hepatocellular carcinoma after hepatectomy: a propensity score analysis. J. Gastroenterol.. 2014.09; 49 (9): 1352-1361. ( PubMed , DOI )

  4. Katsuta E, Tanaka S, Mogushi K, Matsumura S, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Tanaka H, Tanabe M, Arii S.: Age-related clinicopathologic and molecular features of patients receiving curative hepatectomy for hepatocellular carcinoma. Am. J. Surg.. 2014.09; 208 (3): 450-456. ( PubMed , DOI )

  5. Kudo A, Tanaka S, Matsumura S, Ban D, Irie T, Ochiai T, Nakamura N, Arii S.: Anatomic resection reduces the recurrence of solitary hepatocellular carcinoma <5 cm without macrovascular invasion. Am. J. Surg.. 2014.06; 207 (6): 863-869. ( PubMed , DOI )

  6. Miura T, Ban D, Koyama T, Kudo A, Ochiai T, Irie T, Nakamura N, Tanaka S, Arii S.: Severe postoperative hemorrhage caused by antibody-mediated coagulation factor deficiencies: report of two cases. Surg. Today. 2014.05; 44 (5): 976-981. ( PubMed , DOI )

  7. Ogawa K, Tanaka S, Matsumura S, Murakata A, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Tanabe M, Arii S.: EpCAM-targeted therapy for human hepatocellular carcinoma. Ann. Surg. Oncol.. 2014.04; 21 (4): 1314-1322. ( PubMed , DOI )

  8. Kudo A, Igari T, Kumagai J, Tanaka S, Ban D, Noguchi N, Irie T, Nakamura N, Arii S.: A simple index to predict liver functional reserve after hepatectomy. Hepatogastroenterology. 2014.04; 61 712-716.

  9. Kudo A, Mogushi K, Takayama T, Matsumura S, Ban D, Irie T, Ochiai T, Nakamura N, Tanaka H, Anzai N, Sakamoto M, Tanaka S, Arii S.: Mitochondrial metabolism in the noncancerous liver determine the occurrence of hepatocellular carcinoma: a prospective study. J. Gastroenterol.. 2014.03; 49 (3): 502-510. ( PubMed , DOI )

  10. L Chen, L Fu, X Kong, J Xu, Z Wang, X Ma, Y Akiyama, Y Chen, J Fang: Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer. Br. J. Cancer. 2014.02; 110 (4): 1014-1026. ( PubMed , DOI )

  11. Yasui Y, Kudo A, Kurosaki M, Matsuda S, Muraoka M, Tamaki N, Suzuki S, Hosokawa T, Ueda K, Matsunaga K, Nakanishi H, Tsuchiya K, Itakura J, Takahashi Y, Tanaka S, Asahina Y, Enomoto N, Arii S, Izumi N.: Reduced organic anion transporter expression is a risk factor for hepatocellular carcinoma in chronic hepatitis C patients: a propensity score matching study. Oncology. 2014.01; 86 (1): 53-62. ( PubMed , DOI )

  12. Kano Y, Konno M, Kawamoto K, Tamari K, Hayashi K, Fukusumi T, Satoh T, Tanaka S, Ogawa K, Mori M, Doki Y, Ishii H: Novel drug discovery system for cancer stem cells in human squamous cell carcinoma of the esophagus. Oncology Reports. 2014; 86 (1): 53-62.

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  2. Yutaka Hashimoto, Yoshimitsu Akiyama, Yasuhito Yuasa: Multiple-to-multiple relationships between microRNAs and target genes in gastric cancer. PLoS ONE. 2013.05; 8 (5): e62589. ( PubMed , DOI )

  3. Donglai Wang, Jingyi Zhou, Xiangyu Liu, Danyu Lu, Changchun Shen, Yipeng Du, Fu-Zheng Wei, Boyan Song, Xiaopeng Lu, Yu Yu, Lina Wang, Ying Zhao, Haiying Wang, Yang Yang, Yoshimitsu Akiyama, Hongquan Zhang, Wei-Guo Zhu: Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability. Proc. Natl. Acad. Sci. U.S.A.. 2013.04; 110 (14): 5516-5521. ( PubMed , DOI )

  4. Rotkrua P, Shimada S, Mogushi K, Akiyama Y, Tanaka H, Yuasa Y: Circulating microRNAs as biomarkers for early detection of diffuse-type gastric cancer using a mouse model. British Journal of Cancer. 2013.03; 108 (4): 932-940. ( PubMed )

  5. Fukamachi H, Seol HS, Shimada S, Funasaka C, Baba K, Kim JH, Park YS, Kim MJ, Kato K, Inokuchi M, Kawachi H, Yook JH, Eishi Y, Kojima K, Kim WH, Jang SJ, Yuasa Y: CD49f(high) cells retain sphere-forming and tumor-initiating activities in human gastric tumors. PLoS ONE. 2013; 8 (8): e72438. ( PubMed )

  6. Sato K, Tanaka S, Mitsunori Y, Mogushi K, Yasen M, Aihara A, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Tanaka H, Arii S.: Sato K, Tanaka S, Mitsunori Y, Mogushi K, Yasen M, Aihara A, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Tanaka H, Arii S. Contrast-enhanced intraoperative ultrasonography for vascular imaging of hepatocellular carcinoma; clinical and biological significance. Hepatology, 57:1436-1447, 2013 Hepatology, 57:1436-1447, 2013. 2013;

  7. Muramatsu S, Tanaka S, Mogushi K, Adikrisna R, Aihara A, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Tanaka H, Nakayama K, Tanaka H, Yamaoka S, Arii S. : Muramatsu S, Tanaka S, Mogushi K, Adikrisna R, Aihara A, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Tanaka H, Nakayama K, Tanaka H, Yamaoka S, Arii S. Visualization of stem cell features in human hepatocellular carcinoma enlightened in vivo significance of tumor-host interaction and clinical implication. Hepatology, 58:218-228, 2013 Hepatology. 2013; 58 218 -228.

  1. Yasuhito Yuasa, Hiromi Nagasaki, Isao Oze, Yoshimitsu Akiyama, Shunsuke Yoshida, Kouhei Shitara, Seiji Ito, Satoyo Hosono, Miki Watanabe, Hidemi Ito, Hideo Tanaka, Daehee Kang, Kai-Feng Pan, Wei-Cheng You, Keitaro Matsuo: Insulin-like growth factor 2 hypomethylation of blood leukocyte DNA is associated with gastric cancer risk. Int. J. Cancer. 2012.12; 131 (11): 2596-2603. ( PubMed , DOI )

  2. Shimada S, Mimata A, Sekine M, Mogushi K, Akiyama Y, Fukamachi H, Jonkers J, Tanaka H, Eishi Y, Yuasa Y: Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer. Gut. 2012.03; 61 (3): 344-353. ( PubMed )

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  4. Matsumura S, Imoto I, Kozaki K, Matsui T, Muramatsu T, Furuta M, Tanaka S, Sakamoto M, Arii S, Inazawa J. : Matsumura S, Imoto I, Kozaki K, Matsui T, Muramatsu T, Furuta M, Tanaka S, Sakamoto M, Arii S, Inazawa J. Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor-suppressor in hepatocellular carcinoma. Clinical Cancer Research, 18:3541-3551, 2012 Clinical Cancer Research, 18:3541-3551, 2012. 2012;

  5. Tanaka S, Arii S.: Tanaka S, Arii S. Molecular targeted therapy in hepatocellular carcinoma. Seminars in Oncology, 39:486-92, 2012 Seminars in Oncology, 39:486-92, 2012. 2012;

  6. Adikrisna R, Tanaka S, Muramatsu S, Aihara A, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Yamaoka S, Arii S: Adikrisna R, Tanaka S, Muramatsu S, Aihara A, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Yamaoka S, Arii S. Identification of pancreatic cancer stem cells and selective toxicity of chemotherapeutic agents. Gastroenterology, 143:234-245, 2012 Gastroenterology, 143:234-245, 2012 . 2012;

  1. Pichayanoot Rotkrua, Yoshimitsu Akiyama, Yutaka Hashimoto, Takeshi Otsubo, Yasuhito Yuasa: MiR-9 downregulates CDX2 expression in gastric cancer cells. Int. J. Cancer. 2011.12; 129 (11): 2611-2620. ( PubMed , DOI )

  2. Fukamachi H, Shmada S, Ito K, Ito Y, Yuasa Y: CD133 is a marker of gland-forming cells in gastric tumors and Sox17 is involved in its regulation. Cancer Science. 2011.07; 102 (7): 1313-1321. ( PubMed )

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  5. Tanaka S, Mogushi K, Yasen M, Ban D, Noguchi N, Kudo A, Nakamura N, Tanaka H, Yamamoto M, Kokudo N, Takayama T, Kawasaki S, Sakamoto M, Arii S. : Tanaka S, Mogushi K, Yasen M, Ban D, Noguchi N, Kudo A, Nakamura N, Tanaka H, Yamamoto M, Kokudo N, Takayama T, Kawasaki S, Sakamoto M, Arii S. Oxidative stress pathways in non-cancerous human liver tissue to predict hepatocellular carcinoma recurrence; a prospective multi-center study. Hepatology, 54:1273-1281, 2011 Hepatology, 54:1273-1281, 2011. 2011;

  6. Murakata A, Tanaka S, Mogushi K, Yasen M, Noguchi N, Irie T, Kudo A, Nakamura N, Tanaka H, Arii S: Murakata A, Tanaka S, Mogushi K, Yasen M, Noguchi N, Irie T, Kudo A, Nakamura N, Tanaka H, Arii S. Gene expression signature of the gross morphology in hepatocellular carcinoma. Annals of Surgery, 253:94-100, 2011 Annals of Surgery, 253:94-100, 2011. 2011;

  7. Otsubo T, Akiyama Y, Hashimoto Y, Shimada S, Goto K, Yuasa Y: MicroRNA-126 inhibits SOX2 expression and contributes to gastric carcinogenesis. PLoS ONE. 2011; 6 (1): e16617. ( PubMed )

  1. Rie Wada, Yoshimitsu Akiyama, Yutaka Hashimoto, Hiroshi Fukamachi, Yasuhito Yuasa: miR-212 is downregulated and suppresses methyl-CpG-binding protein MeCP2 in human gastric cancer. Int. J. Cancer. 2010.09; 127 (5): 1106-1114. ( PubMed , DOI )

  2. Hashimoto Y, Akiyama Y, Otsubo T, Shimada S, Yuasa Y: Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis. Carcinogenesis. 2010.05; 31 (5): 777-784. ( PubMed )

  3. Xian-Zi Wen, Yoshimitsu Akiyama, Kai-Feng Pan, Zhao-Jun Liu, Zhe-Ming Lu, Jing Zhou, Lian-Kun Gu, Cai-Xuan Dong, Bu-Dong Zhu, Jia-Fu Ji, Wei-Cheng You, Da-Jun Deng: Methylation of GATA-4 and GATA-5 and development of sporadic gastric carcinomas. World J. Gastroenterol.. 2010.03; 16 (10): 1201-1208. ( PubMed )

  4. Aihara A, Tanaka S, Yasen M, Matsumura S, Mitsunori Y, Murakata A, Noguchi N, Kudo A, Nakamura N, Ito K, Arii S: Aihara A, Tanaka S, Yasen M, Matsumura S, Mitsunori Y, Murakata A, Noguchi N, Kudo A, Nakamura N, Ito K, Arii S. The selective Aurora B kinase inhibitor AZD1152 as a novel treatment for hepatocellular carcinoma. Journal of Hepatology, 52:63-71, 2010 Journal of Hepatology, 52:63-71, 2010. 2010;

  1. Debby M E I Hellebrekers, Marjolein H F M Lentjes, Sandra M van den Bosch, Veerle Melotte, Kim A D Wouters, Kathleen L J Daenen, Kim M Smits, Yoshimitsu Akiyama, Yasuhito Yuasa, Silvia Sanduleanu, Carolina A J Khalid-de Bakker, Daisy Jonkers, Matty P Weijenberg, Joost Louwagie, Wim van Criekinge, Beatriz Carvalho, Gerrit A Meijer, Stephen B Baylin, James G Herman, Adriaan P de Bruïne, Manon van Engeland: GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer. Clin. Cancer Res.. 2009.06; 15 (12): 3990-3997. ( PubMed , DOI )

  2. Yasuhito Yuasa, Hiromi Nagasaki, Yoshimitsu Akiyama, Yutaka Hashimoto, Touichirou Takizawa, Kazuyuki Kojima, Tatsuyuki Kawano, Kenichi Sugihara, Kazue Imai, Kei Nakachi: DNA methylation status is inversely correlated with green tea intake and physical activity in gastric cancer patients. Int. J. Cancer. 2009.06; 124 (11): 2677-2682. ( PubMed , DOI )

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  1. Aira Wanajo, Akane Sasaki, Hiromi Nagasaki, Shu Shimada, Takeshi Otsubo, Syuichi Owaki, Yasufumi Shimizu, Yoshinobu Eishi, Kazuyuki Kojima, Yasuaki Nakajima, Tatsuyuki Kawano, Yasuhito Yuasa, Yoshimitsu Akiyama: Methylation of the calcium channel-related gene, CACNA2D3, is frequent and a poor prognostic factor in gastric cancer. Gastroenterology. 2008.08; 135 (2): 580-590. ( PubMed , DOI )

  2. Jin SH, Akiyama Y, Fukamachi H, Yanagihara K, Akashi T, Yuasa Y: IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells. Int J Cancer. 2008.03; 122 (5): 1040-1046. ( PubMed , DOI )

  3. Otsubo T, Akiyama Y, Yanagihara K, Yuasa Y: SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis. Br J Cancer. 2008.02; 98 (4): 824-831. ( PubMed , DOI )

  4. Tanaka S, Arii S, Yasen M, Mogusi K, Su N-T, Zhao C, Imoto I, Eishi Y, Inazawa J, Miki Y, Tanaka H.: Tanaka S, Arii S, Yasen M, Mogusi K, Su N-T, Zhao C, Imoto I, Eishi Y, Inazawa J, Miki Y, Tanaka H. Aurora kinase B is a predictive factor for aggressive recurrence of hepatocellular carcinoma after curative hepatectomy. British Journal of Surgery, 95:611-619, 2008 British Journal of Surgery, 95:611-619, 2008. 2008;

  1. Jinawath A, Akiyama Y, Sripa B, Yuasa Y: Dual blockade of the Hedgehog and ERK1/2 pathways coordinately decreases proliferation and survival of cholangiocarcinoma cells. J Cancer Res Clin Oncol. 2007.04; 133 (4): 271-278. ( PubMed , DOI )

  2. Tani Y, Akiyama Y, Fukamachi H, Yanagihara K, Yuasa Y: Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression. J Cancer Res Clin Oncol. 2007.04; 133 (4): 263-269. ( PubMed , DOI )

  3. Tanaka S, Noguchi N, Ochiai T, Kudo A, Nakamura N, Ito K, Kawamura T, Teramoto K, Arii S. : Tanaka S, Noguchi N, Ochiai T, Kudo A, Nakamura N, Ito K, Kawamura T, Teramoto K, Arii S. Outcomes and recurrence of initially resection of hepatocellular carcinoma meeting Milan criteria: Rationale for partial hepatectomy as first strategy. Journal of the American College of Surgeons, 204:1-6, 2007 Journal of the American College of Surgeons, 204:1-6, 2007. 2007;

  1. Jinawath A, Akiyama Y, Yuasa Y, Pairojkul C: Expression of phosphorylated ERK1/2 and homeodomain protein CDX2 in cholangiocarcinoma. J Cancer Res Clin Oncol. 2006.12; 132 (12): 805-810. ( PubMed , DOI )

  2. Guo M, House MG, Akiyama Y, Qi Y, Capagna D, Harmon J, Baylin SB, Brock MV, Herman JG: Hypermethylation of the GATA gene family in esophageal cancer. Int J Cancer. 2006.11; 119 (9): 2078-2083. ( PubMed , DOI )

  3. Wakana K, Akiyama Y, Aso T, Yuasa Y: Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis. Cancer Lett. 2006.09; 241 (2): 281-288. ( PubMed , DOI )

  4. Sekine A, Akiyama Y, Yanagihara K, Yuasa Y: Hath1 up-regulates gastric mucin gene expression in gastric cells. Biochem Biophys Res Commun. 2006.06; 344 (4): 1166-1171. ( PubMed , DOI )

  5. Wen XZ, Akiyama Y, Baylin SB, Yuasa Y: Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas. Oncogene. 2006.04; 25 (18): 2666-2673. ( PubMed , DOI )

  6. Tanaka S, Pero SC, Taguchi K, Shimada M, Mori M, Krag DN, Arii S: Tanaka S, Pero SC, Taguchi K, Shimada M, Mori M, Krag DN, Arii S. Specific peptide ligand for Grb7 signal transduction protein and pancreatic cancer metastasis. Journal of the National Cancer Institute, 98:491-498, 2006 Journal of the National Cancer Institute, 98:491-498, 2006. 2006;

  1. Galm O, Suzuki H, Akiyama Y, Esteller M, Brock MV, Osieka R, Baylin SB, Herman JG: Inactivation of the tissue inhibitor of metalloproteinases-2 gene by promoter hypermethylation in lymphoid malignancies. Oncogene. 2005.07; 24 (30): 4799-4805. ( PubMed , DOI )

  2. Wu XS, Akiyama Y, Igari T, Kawamura T, Hiranuma S, Shibata T, Tsuruta K, Koike M, Arii S, Yuasa Y: Expression of homeodomain protein CDX2 in gallbladder carcinomas. J Cancer Res Clin Oncol. 2005.05; 131 (5): 271-278. ( PubMed , DOI )

  3. Jinawath A, Miyake S, Yanagisawa Y, Akiyama Y, Yuasa Y: Transcriptional regulation of the human DNA methyltransferase 3A and 3B genes by Sp3 and Sp1 zinc finger proteins. Biochem J. 2005.01; 385 (Pt 2): 557-564. ( PubMed , DOI )

  4. Yuasa Y, Nagasaki H, Akiyama Y, Sakai H, Nakajima T, Ohkura Y, Takizawa T, Koike M, Tani M, Iwai T, Sugihara K, Imai K, Nakachi K: Relationship between CDX2 gene methylation and dietary factors in gastric cancer patients. Carcinogenesis. 2005.01; 26 (1): 193-200. ( PubMed , DOI )

  5. Merle P, Kim M, Herrmann M, Gupte A, Lefrancois L, Califano S, Trepo C, Tanaka S, Vitvitski L, Monte SD, Wands JR: Merle P, Kim M, Herrmann M, Gupte A, Lefrancois L, Califano S, Trepo C, Tanaka S, Vitvitski L, Monte SD, Wands JR. Oncogenic role of the frizzled-7/beta-catenin pathway in hepatocellular carcinoma. Journal of Hepatology, 43:854-62, 2005 Journal of Hepatology, 43:854-62, 2005. 2005;

  6. Harimoto N, Taketomi A, Kitagawa D, Kuroda Y, Itoh S, Gion T, Tanaka S, Shirabe K, Shimada M, Maehara Y: Harimoto N, Taketomi A, Kitagawa D, Kuroda Y, Itoh S, Gion T, Tanaka S, Shirabe K, Shimada M, Maehara Y. The newly established human hepatocyte cell line: application for the bioartificial liver. Journal of Hepatology, 42:557-64, 2005 Journal of Hepatology, 42:557-64, 2005. 2005;

  1. Guo M, Akiyama Y, House MG, Hooker CM, Heath E, Gabrielson E, Yang SC, Han Y, Baylin SB, Herman JG, Brock MV: Hypermethylation of the GATA genes in lung cancer. Clin Cancer Res. 2004.12; 10 (23): 7917-7924. ( PubMed , DOI )

  2. Ren CY, Akiyama Y, Miyake S, Yuasa Y: Transcription factor GATA-5 selectively up-regulates mucin gene expression. J Cancer Res Clin Oncol. 2004.05; 130 (5): 245-252. ( PubMed , DOI )

  3. Suzuki H, Watkins DN, Jair KW, Schuebel KE, Markowitz SD, Chen WD, Pretlow TP, Yang B, Akiyama Y, Van Engeland M, Toyota M, Tokino T, Hinoda Y, Imai K, Herman JG, Baylin SB: Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet. 2004.04; 36 (4): 417-422. ( PubMed , DOI )

  4. Sakai H, Eishi Y, Li XL, Akiyama Y, Miyake S, Takizawa T, Konishi N, Tatematsu M, Koike M, Yuasa Y: PDX1 homeobox protein expression in pseudopyloric glands and gastric carcinomas. Gut. 2004.03; 53 (3): 323-330. ( PubMed )

  5. Douglas DB, Akiyama Y, Carraway H, Belinsky SA, Esteller M, Gabrielson E, Weitzman S, Williams T, Herman JG, Baylin SB: Hypermethylation of a small CpGuanine-rich region correlates with loss of activator protein-2alpha expression during progression of breast cancer. Cancer Res. 2004.03; 64 (5): 1611-1620. ( PubMed )

  6. Wen XZ, Miyake S, Akiyama Y, Yuasa Y: BMP-2 modulates the proliferation and differentiation of normal and cancerous gastric cells. Biochem Biophys Res Commun. 2004.03; 316 (1): 100-106. ( PubMed , DOI )

  7. Li XL, Eishi Y, Bai YQ, Sakai H, Akiyama Y, Tani M, Takizawa T, Koike M, Yuasa Y: Expression of the SRY-related HMG box protein SOX2 in human gastric carcinoma. Int J Oncol. 2004.02; 24 (2): 257-263. ( PubMed )

  8. Osoegawa A, Yoshino I, Tanaka S, Sugio K, Kameyama T, Yamaguchi M, Maehara Y. : Osoegawa A, Yoshino I, Tanaka S, Sugio K, Kameyama T, Yamaguchi M, Maehara Y. Regulation of p27 by S-phase kinase-associated protein 2 is associated with aggressiveness in non-small-cell lung cancer. Journal of Clinical Oncology, 22:4165-73, 2004 Journal of Clinical Oncology, 22:4165-73, 2004. 2004;

  9. Merle P, de la Monte S, Kim M, Herrmann M, Tanaka S, Von Dem Bussche A, Kew MC, Trepo C, Wands JR. : Merle P, de la Monte S, Kim M, Herrmann M, Tanaka S, Von Dem Bussche A, Kew MC, Trepo C, Wands JR. Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma. Gastroenterology, 127(4):1110-22, 2004 Gastroenterology, 127(4):1110-22, 2004. 2004;

  10. Maehara Si, Tanaka S, Saito , Shirabe K, Maehara Y. : Maehara Si, Tanaka S, Saito , Shirabe K, Maehara Y. Selenoprotein P, as a predictor for evaluating gemcitabine resistance in human pancreatic cancer cells. International Journal of Cancer, 112:184-9, 2004 International Journal of Cancer, 112:184-9, 2004. 2004;

  1. Akiyama Y, Watkins N, Suzuki H, Jair KW, van Engeland M, Esteller M, Sakai H, Ren CY, Yuasa Y, Herman JG, Baylin SB: GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer. Mol Cell Biol. 2003.12; 23 (23): 8429-8439. ( PubMed )

  2. Brock MV, Gou M, Akiyama Y, Muller A, Wu TT, Montgomery E, Deasel M, Germonpre P, Rubinson L, Heitmiller RF, Yang SC, Forastiere AA, Baylin SB, Herman JG: Prognostic importance of promoter hypermethylation of multiple genes in esophageal adenocarcinoma. Clin Cancer Res. 2003.08; 9 (8): 2912-2919. ( PubMed )

  3. Tanaka S, Sugimachi K, Maehara Si, Shimada M, Maehara Y. : Tanaka S, Sugimachi K, Maehara Si, Shimada M, Maehara Y. A loss of function mutation in WISP3 derived from microsatellite unstable gastric carcinoma. Gastroenterology, 125:1563-4, 2003 Gastroenterology, 125:1563-4, 2003. 2003;

  4. Tanaka S, Sugimachi K, Kameyama T, Maehara Si, Shirabe K, Shimada M, Wands JR, Maehara Y. : Tanaka S, Sugimachi K, Kameyama T, Maehara Si, Shirabe K, Shimada M, Wands JR, Maehara Y. Human WISP1v, a member of CCN family, is associated with invasive cholangiocarcinoma. Hepatology, 37:1122-9, 2003 Hepatology, 37:1122-9, 2003. 2003;

  1. Bai YQ, Yamamoto H, Akiyama Y, Tanaka H, Takizawa T, Koike M, Kenji Yagi O, Saitoh K, Takeshita K, Iwai T, Yuasa Y: Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach. Cancer Lett. 2002.02; 176 (1): 47-55. ( PubMed )

  2. Tanaka S, Sugimachi K, Shimada M, Maehara Y, Sugimachi K. : Tanaka S, Sugimachi K, Shimada M, Maehara Y, Sugimachi K. Variant WISPs as targets for gastrointestinal carcinomas. Gastroenterology, 123:392-3, 2002 Gastroenterology, 123:392-3, 2002. 2002;

  3. Tanaka S, Sugimachi K, Yamashita Yi, Ohga T, Shirabe K, Shimada M, Wands JR, Sugimachi K. : Tanaka S, Sugimachi K, Yamashita Yi, Ohga T, Shirabe K, Shimada M, Wands JR, Sugimachi K. Tie2 vascular endothelial receptor expression and function in hepatocellular carcinoma. Hepatology, 35:861-7, 2002 Hepatology, 35:861-7, 2002. 2002;

  1. Esteller M, Fraga MF, Guo M, Garcia-Foncillas J, Hedenfalk I, Godwin AK, Trojan J, Vaurs-Barriere C, Bignon YJ, Ramus S, Benitez J, Caldes T, Akiyama Y, Yuasa Y, Launonen V, Canal MJ, Rodriguez R, Capella G, Peinado MA, Borg A, Aaltonen LA, Ponder BA, Baylin SB, Herman JG: DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. Hum Mol Genet. 2001.12; 10 (26): 3001-3007. ( PubMed )

  2. Nakajima T, Akiyama Y, Shiraishi J, Arai T, Yanagisawa Y, Ara M, Fukuda Y, Sawabe M, Saitoh K, Kamiyama R, Hirokawa K, Yuasa Y: Age-related hypermethylation of the hMLH1 promoter in gastric cancers. Int J Cancer. 2001.10; 94 (2): 208-211. ( PubMed )

  3. Akiyama Y, Nagasaki H, Nakajima T, Sakai H, Nomizu T, Yuasa Y: Infrequent frameshift mutations in the simple repeat sequences of hMLH3 in hereditary nonpolyposis colorectal cancers. Jpn J Clin Oncol. 2001.02; 31 (2): 61-64. ( PubMed )

  4. Sato Y, Akiyama Y, Tanizawa T, Shibata T, Saito K, Mori S, Kamiyama R, Yuasa Y: Molecular characterization of the genomic breakpoint junction in the t(11;18) (q21;q21) translocation of a gastric MALT lymphoma. Biochem Biophys Res Commun. 2001.01; 280 (1): 301-306. ( PubMed , DOI )

  5. Yamashita Yi, Shimada M, Hamatsu T, Rikimaru T, Tanaka S, Shirabe K, Sugimachi K. : Yamashita Yi, Shimada M, Hamatsu T, Rikimaru T, Tanaka S, Shirabe K, Sugimachi K. Electroporation-mediated interleukin-12 gene therapy for hepatocellular carcinoma in the mice model. Cancer Research, 61:1005–1012, 2001 Cancer Research, 61:1005–1012, 2001. 2001;

  6. Sugimachi K, Aishima S, Taguchi K, Tanaka S, Shimada M, Kajiyama K, Sugimachi K, Tsuneyoshi M. : Sugimachi K, Aishima S, Taguchi K, Tanaka S, Shimada M, Kajiyama K, Sugimachi K, Tsuneyoshi M. The role of overexpression and gene amplification of cyclin D1 in intrahepatic cholangiocarcinoma. Journal of Hepatology, 35:74-79, 2001 Journal of Hepatology, 35:74-79, 2001. 2001;

  7. Etoh T, Inoue H, Tanaka S, Bernard GF, Kitano S, Mori M. : Etoh T, Inoue H, Tanaka S, Bernard GF, Kitano S, Mori M. Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: Possible in vivo regulation via induction of proteases. Cancer Research, 61:2145-2153, 2001 Cancer Research, 61:2145-2153, 2001. 2001;

  8. Tanaka S, Sugimachi K, Saeki H, Kinoshita J, Ohga T, Shimada M, Maehara Y, Sugimachi K. : Tanaka S, Sugimachi K, Saeki H, Kinoshita J, Ohga T, Shimada M, Maehara Y, Sugimachi K. A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma. Oncogene, 20:5525-32, 2001 Oncogene, 20:5525-32, 2001. 2001;

  1. Akiyama Y, Nagasaki H, Yagi KO, Nomizu T, Yuasa Y: Beta-catenin and adenomatous polyposis coli (APC) mutations in adenomas from hereditary non-polyposis colorectal cancer patients. Cancer Lett. 2000.09; 157 (2): 185-191. ( PubMed )

  2. Iida S, Akiyama Y, Nakajima T, Ichikawa W, Nihei Z, Sugihara K, Yuasa Y: Alterations and hypermethylation of the p14(ARF) gene in gastric cancer. Int J Cancer. 2000.09; 87 (5): 654-658. ( PubMed )

  3. Bai Y, Akiyama Y, Nagasaki H, Yagi OK, Kikuchi Y, Saito N, Takeshita K, Iwai T, Yuasa Y: Distinct expression of CDX2 and GATA4/5, development-related genes, in human gastric cancer cell lines. Mol Carcinog. 2000.07; 28 (3): 184-188. ( PubMed )

  4. Furihata M, Shuin T, Takeuchi T, Sonobe H, Ohtsuki Y, Akiyama Y, Yuasa Y: Missense mutation of the hMSH6 and p53 genes in sporadic urothelial transitional cell carcinoma. Int J Oncol. 2000.03; 16 (3): 491-496. ( PubMed )

  5. Yanagisawa Y, Akiyama Y, Iida S, Ito E, Nomizu T, Sugihara K, Yuasa Y, Maruyama K: Methylation of the hMLH1 promoter in familial gastric cancer with microsatellite instability. Int J Cancer. 2000.01; 85 (1): 50-53. ( PubMed )

  6. Tanaka S, Sugimachi K, Shirabe K, Shimada M, Wands JR, Sugimachi K. : Tanaka S, Sugimachi K, Shirabe K, Shimada M, Wands JR, Sugimachi K. Expression and anti-tumor effects of TRAIL in human cholangiocarcinoma. Hepatology, 32:523-527, 2000 Hepatology, 32:523-527, 2000. 2000;

  1. Akiyama Y, Arai T, Nagasaki H, Yagi OK, Nakahata A, Nakajima T, Ohkura Y, Iwai T, Saitoh K, Yuasa Y: Frequent allelic imbalance on chromosome 18q21 in early superficial colorectal cancers. Jpn J Cancer Res. 1999.12; 90 (12): 1329-1337. ( PubMed )

  2. Arai T, Akiyama Y, Nagasaki H, Murase N, Okabe S, Ikeuchi T, Saito K, Iwai T, Yuasa Y: EXTL3/EXTR1 alterations in colorectal cancer cell lines. Int J Oncol. 1999.11; 15 (5): 915-919. ( PubMed )

  3. Bai YQ, Akiyama Y, Nagasaki H, Lu SL, Arai T, Morisaki T, Kitamura M, Muto A, Nagashima M, Nomizu T, Iwama T, Itoh H, Baba S, Iwai T, Yuasa Y: Predominant germ-line mutation of the hMSH2 gene in Japanese hereditary non-polyposis colorectal cancer kindreds. Int J Cancer. 1999.08; 82 (4): 512-515. ( PubMed )

  4. Iida S, Akiyama Y, Ichikawa W, Yamashita T, Nomizu T, Nihei Z, Sugihara K, Yuasa Y: Infrequent germ-line mutation of the E-cadherin gene in Japanese familial gastric cancer kindreds. Clin Cancer Res. 1999.06; 5 (6): 1445-1447. ( PubMed )

  5. Ito E, Yanagisawa Y, Iwahashi Y, Suzuki Y, Nagasaki H, Akiyama Y, Sugano S, Yuasa Y, Maruyama K: A core promoter and a frequent single-nucleotide polymorphism of the mismatch repair gene hMLH1. Biochem Biophys Res Commun. 1999.03; 256 (3): 488-494. ( PubMed , DOI )

  6. Yagi OK, Akiyama Y, Yuasa Y: Genomic structure and alterations of homeobox gene CDX2 in colorectal carcinomas. Br J Cancer. 1999.02; 79 (3-4): 440-444. ( PubMed , DOI )

  7. Tokumitsu Y, Mori M, Tanaka S, Akazawa K, Nakano S, Niho Y. Prognostic significance of polo-like kinase expression in esophageal carcinoma. International Journal of Oncology, 15(4): 687-92, 1999 1999;

  8. Shibata K, Tanaka S, Shiraishi T, Kitano S, Mori M. G-protein gamma 7 is down-regulated in cancers and associated with p 27kip1-induced growth arrest. Cancer Research, 59(5): 1096-101, 1999 Cancer Research, 59(5): 1096-101, 1999. 1999;

  9. Watanabe M, Kuwano H, Tanaka S, Toh Y, Sadanaga N, Sugimachi K. Flow cytometric DNA analysis is useful in detecting multiple genetic alterations in squamous cell carcinoma of the esophagus. Cancer, 85(11): 2322-8, 1999 1999;

  10. de la Monte SM, Ganju N, Tanaka S, Banerjee K, Karl PJ, Brown NV, Wands JR. Differential effects of ethanol on insulin-signaling through the insulin receptor substrate-1. Alcoholism, Clinical and Experimental Research, 23(5): 770-7, 1999 1999;

  11. Fujie T, Tanaka F, Tahara K, Li J, Tanaka S, Mori M, Ueo H, Takesako K, Akiyoshi T. Generation of specific antitumor reactivity by the stimulation of spleen cells from gastric cancer patients with MAGE-3 synthetic peptide. Cancer Immunology and Immunotherapy, 48(4): 189-94, 1999 1999;

  12. Shimada M, Hasegawa H, Gion T, Shirabe K, Taguchi K, Takenaka K, Tanaka S, Sugimachi K. Risk factors of the recurrence of hepatocellular carcinoma originating from residual cancer cells after hepatectomy. Hepatogastroenterology, 46(28): 2469-75, 1999 1999;

  13. Watanabe M, Kuwano H, Tanaka S, Toh Y, Masuda H, Sugimachi K. A significant morphological transformation is recognized in human esophageal cancer cells with an amplification/overexpression of the Cyclin D1 gene. International Journal of Oncology, 15(6): 1103-1108, 1999 1999;

  14. Mori M, Shiraishi T, Tanaka S, Yamagata M, Mafune K, Tanaka Y, Ueo H, Barnard GF, Sugimachi K. Lack of DMBT1 expression in oesophageal, gatric and colon cancer. British Journal of Cancer, 79(2): 211-213, 1999 1999;

  15. Tanaka S, Mori M, Sakamoto Y, Makuuchi M, Sugimachi K, Wands JR. Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma. Journal of Clinical Investigation, 103(3): 341-5, 1999 1999;

  1. Arai T, Akiyama Y, Okabe S, Saito K, Iwai T, Yuasa Y: Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas. Cancer Lett. 1998.11; 133 (2): 197-204. ( PubMed )

  2. Arai T, Akiyama Y, Yamamura A, Hosoi T, Shibata T, Saitoh K, Okabe S, Yuasa Y: Allelotype analysis of early colorectal cancers with lymph node metastasis. Int J Cancer. 1998.08; 79 (4): 418-423. ( PubMed )

  3. Iwahashi Y, Ito E, Yanagisawa Y, Akiyama Y, Yuasa Y, Onodera T, Maruyama K: Promoter analysis of the human mismatch repair gene hMSH2. Gene. 1998.06; 213 (1-2): 141-147. ( PubMed )

  4. Lu SL, Kawabata M, Imamura T, Akiyama Y, Nomizu T, Miyazono K, Yuasa Y: HNPCC associated with germline mutation in the TGF-beta type II receptor gene. Nat Genet. 1998.05; 19 (1): 17-18. ( PubMed , DOI )

  5. Akiyama Y, Yagi OK, Ishikawa T, Nagasaki H, Saitoh K, Yuasa Y: Genetic alterations are frequent in APC but rare in the TGF-beta type II receptor gene in cancer in adenomas of the colon. Cancer Lett. 1998.03; 125 (1-2): 89-96. ( PubMed )

  6. Yagi OK, Akiyama Y, Nomizu T, Iwama T, Endo M, Yuasa Y: Proapoptotic gene BAX is frequently mutated in hereditary nonpolyposis colorectal cancers but not in adenomas. Gastroenterology. 1998.02; 114 (2): 268-274. ( PubMed )

  7. Yanagisawa Y, Ito E, Iwahashi Y, Akiyama Y, Yuasa Y, Maruyama K: Isolation and characterization of the 5' region of the human mismatch repair gene hPMS1. Biochem Biophys Res Commun. 1998.02; 243 (3): 738-743. ( PubMed , DOI )

  8. Arai T, Akiyama Y, Okabe S, Ando M, Endo M, Yuasa Y: Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers. Cancer Lett. 1998.01; 122 (1-2): 157-163. ( PubMed )

  9. Shibata K, Mori M, Tanaka S, Kitano S, Akiyoshi T. Identification and cloning of human G-protein gamma 7, down-regulated in pancreatic cancer. Biochemical and Biophysical Research Communications, 246(1): 205-209, 1998 1998;

  10. Tanaka S, Mori M, Akiyoshi T, Tanaka Y, Mafune K, Wands JR, Sugimachi K.: Tanaka S, Mori M, Akiyoshi T, Tanaka Y, Mafune K, Wands JR, Sugimachi K. A novel variant of human Grb7 is associated with invasive esophageal carcinoma. Journal of Clinical Investigation, 102(4): 821-827, 1998 Journal of Clinical Investigation, 102(4): 821-827, 1998. 1998;

  11. Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K. : Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. Proceedings of the National Academy of Sciences, USA, 95(17): 10164-10169, 1998 Proceedings of the National Academy of Sciences, USA, 95(17): 10164-10169, 1998. 1998;

  12. Tanaka S, Komori K, Sugimachi K. Cytomegalovirus infection in aortic aneurysms. Journal of Vascular Surgery, 27(3): 587-588, 1998 1998;

  13. Mohr L, Tanaka S, Wands JR. Ethanol inhibits hepatocytes proliferation through the IRS-1 signal transduciton pathway in transgene mice. Gastroenterology, 115(6): 1558-65, 1998 1998;

  14. Shiraishi T, Mori M, Tanaka S, Sugimachi K, Akiyoshi T. Identification of cystatin B in human esophageal carcinoma using differential displays in which the gene expression is related to lymph node metastasis. International Journal of Cancer, 79(2): 175-178, 1998 1998;

  15. Mimori K, Mori M, Shiraishi T, Tanaka S, Haraguchi M, Ueo H, Shirasaka C, Akiyoshi. Expression of ornithine decarboxylase mRNA and c-myc mRNA in breast tumours. International Journal of Oncology, 12(3):597-601, 1998 1998;

  16. Yonemitsu Y, Kaneda Y, Tanaka S, Nakashima Y, Komori K, Sugimachi K, Sueishi K. Transfer of wild-type p53 gene effectively inhibits vascular smooth muscle cell proliferation in vitro and in vivo. Circulation Research, 82(2): 147-156, 1998 1998;

  1. Akiyama Y, Sato H, Yamada T, Nagasaki H, Tsuchiya A, Abe R, Yuasa Y: Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred. Cancer Res. 1997.09; 57 (18): 3920-3923. ( PubMed )

  2. Yagi OK, Akiyama Y, Ohkura Y, Ban S, Endo M, Saitoh K, Yuasa Y: Analyses of the APC and TGF-beta type II receptor genes, and microsatellite instability in mucosal colorectal carcinomas. Jpn J Cancer Res. 1997.08; 88 (8): 718-724. ( PubMed )

  3. Akiyama Y, Tsubouchi N, Yuasa Y: Frequent somatic mutations of hMSH3 with reference to microsatellite instability in hereditary nonpolyposis colorectal cancers. Biochem Biophys Res Commun. 1997.07; 236 (2): 248-252. ( PubMed , DOI )

  4. Akiyama Y, Iwanaga R, Saitoh K, Shiba K, Ushio K, Ikeda E, Iwama T, Nomizu T, Yuasa Y: Transforming growth factor beta type II receptor gene mutations in adenomas from hereditary nonpolyposis colorectal cancer. Gastroenterology. 1997.01; 112 (1): 33-39. ( PubMed )

  5. Mimori K, Mori M, Begum NA, Tanaka S, Haraguchi M, Ueo H, Karimine N, Akiyoshi T, Barnard GF. Clinical significance of integrin alpha 6 mRNA expression in gastric carcinoma. International Journal of Oncology, 11(5): 959-964, 1997 1997;

  6. Wands JR, Lavaissiere L, Moradopour D, de la Monte S, Mohr L, Nicolau C, Tanaka S. Immunological approach to hepatocellular carcinoma. Journal of Viral Hepatitis, 4(4): 60-74, 1997 1997;

  7. Mori M, Mimori K, Shiraishi T, Tanaka S, Ueo H, Sugimachi K, Akiyoshi T. p27 expression and gastric carcinoma. Nature Medicine, 3(6): 593, 1997 1997;

  8. Tanaka S, Smidt EV, Mohr L, Sugimachi K, Wands JR. Biological effects of human insulin receptor substrate-1 overexpression in hepatocytes. Hepatology, 26: 598-604, 1997 1997;

  9. Tanaka S, Mori M, Akiyoshi T, Tanaka Y, Mafune K, Wands JR, Sugimachi K. Co-expression of Grb7 with EGFR or Her2/erbB2 in human advanced esophageal carcinoma. Cancer Research, 57: 28-31, 1997 1997;

  1. Akiyama Y, Iwanaga R, Ishikawa T, Sakamoto K, Nishi N, Nihei Z, Iwama T, Saitoh K, Yuasa Y: Mutations of the transforming growth factor-beta type II receptor gene are strongly related to sporadic proximal colon carcinomas with microsatellite instability. Cancer. 1996.12; 78 (12): 2478-2484. ( PubMed )

  2. Lu SL, Zhang WC, Akiyama Y, Nomizu T, Yuasa Y: Genomic structure of the transforming growth factor beta type II receptor gene and its mutations in hereditary nonpolyposis colorectal cancers. Cancer Res. 1996.10; 56 (20): 4595-4598. ( PubMed )

  3. Hori H, Miyake S, Akiyama Y, Endo M, Yuasa Y: Clonal heterogeneity in human esophageal squamous cell carcinomas on DNA analysis. Jpn J Cancer Res. 1996.09; 87 (9): 923-929. ( PubMed )

  4. Akiyama Y, Nakasaki H, Nihei Z, Iwama T, Nomizu T, Utsunomiya J, Yuasa Y: Frequent microsatellite instabilities and analyses of the related genes in familial gastric cancers. Jpn J Cancer Res. 1996.06; 87 (6): 595-601. ( PubMed )

  5. Lu SL, Akiyama Y, Nagasaki H, Nomizu T, Ikeda E, Baba S, Ushio K, Iwama T, Maruyama K, Yuasa Y: Loss or somatic mutations of hMSH2 occur in hereditary nonpolyposis colorectal cancers with hMSH2 germline mutations. Jpn J Cancer Res. 1996.03; 87 (3): 279-287. ( PubMed )

  6. Sasaki A, Nagashima M, Shiseki M, Katai H, Maruyama K, Iwanaga R, Akiyama Y, Yuasa Y, Yokota J: Microsatellite instability in gastric cancer prone families. Cancer Lett. 1996.02; 99 (2): 169-175. ( PubMed )

  7. Tanaka S, Ito T, Wands JR.: Tanaka S, Ito T, Wands JR. Neoplastic transformation induced by insulin receptor substrate-1 overexpression requires an interaction with Grb2 and Syp signaling molecules. Journal of Biological Chemistry, 271(24): 14610-6, 1996 Journal of Biological Chemistry, 271(24): 14610-6, 1996 . 1996;

  8. Tanaka S, Wands JR: Tanaka S, Wands JR. A carboxy-terminal truncated IRS-1 dominant negative protein reverses the human hepatocellular carcinoma malignant phenotype. Journal of Clinical Investigation, 98(9): 2100-8, 1996 Journal of Clinical Investigation, 98(9): 2100-8, 1996. 1996;

  9. Tanaka S, Takenaka K, Matsumata T, Mori R, Sugimachi K. Hepatitis C virus replication is associated with expression of transforming growth factor-alpha and insulin-like growth factor-II in cirrhotic livers. Digestive Diseases and Sciences, 41(1): 208-15, 1996 1996;

  10. Yonemitsu Y, Nakagawa K, Tanaka S, Mori R, Sugimachi K, Sueishi K. In situ detection of frequent and active infection of human cytomegalovirus in inflammatory abdominal aortic aneurysms: possible pathogenic role in sustained chronic inflammatory reaction. Laboratory Investigation, 74(4): 723-36, 1996 1996;

  11. Tanaka S, Wands JR: Tanaka S, Wands JR. Insulin receptor substrate-1 overexpression in human hepatocellular carcinoma cells prevents transforming growth factor-beta1 induced apoptosis. Cancer Research, 56: 3391-4, 1996 Cancer Research, 56: 3391-4, 1996. 1996;

  1. Lu SL, Akiyama Y, Nagasaki H, Saitoh K, Yuasa Y: Mutations of the transforming growth factor-beta type II receptor gene and genomic instability in hereditary nonpolyposis colorectal cancer. Biochem Biophys Res Commun. 1995.11; 216 (2): 452-457. ( PubMed , DOI )

  2. Oto M, Suehiro T, Akiyama Y, Yuasa Y: Microsatellite instability in cancer identified by non-gel sieving capillary electrophoresis. Clin Chem. 1995.03; 41 (3): 482-483. ( PubMed )

  3. 秋山好光, 斎藤澄, 大倉康男, 伴慎一, 中村恭一: PCNA発現を指標としたヒト胃癌の増殖動態の研究-画像解析による定量的検討の試み- 胃と腸. 1995.01; 30 (1): 113-119.

  4. Li YY, Minagawa H, Tanaka S, Mori R. Suppression of infectious virus spread to the liver by foscarnet following lethal infection of acyclovir-resistant herpes simplex virus type 2 in mice. Antiviral Research, 27(1-2): 111-21, 1995 1995;

  5. Mimori K, Mori M, Tanaka S, Akiyoshi T, Sugimachi K. The overexpression of elongation factor 1 gamma mRNA in gastric carcinoma. Cancer, 75(6): 1446-9, 1995 1995;

  1. Wu C, Akiyama Y, Imai K, Miyake S, Nagasaki H, Oto M, Okabe S, Iwama T, Mitamura K, Masumitsu H, et al.: DNA alterations in cells from hereditary non-polyposis colorectal cancer patients. Oncogene. 1994.03; 9 (3): 991-994. ( PubMed )

  2. Mori M, Watanabe M, Tanaka S, Mimori K, Kuwano H, Sugimachi K. Epstein-Barr virus-associated carcinomas of the esophagus and stomach. Archives of Pathology & Laboratory Medicine, 118(10): 998-1001, 1994 1994;

  3. Minagawa H, Tanaka S, Toh Y, Mori R. Detection of herpes simplex virus type 1-encoded RNA by polymerase chain reaction: different pattern of viral RNA detection in latently infected murine trigeminal ganglia following in vitro or in vivo reactivation. Journal of General Virology, 75(3): 647-50, 1994 1994;

  4. Tanaka S, Komori K, Okadome K, Sugimachi K, Mori R. Detection of active cytomegalovirus infection in inflammatory aortic aneurysms with RNA polymerase chain reaction. Journal of Vascular Surgery, 20(2): 235-43, 1994 1994;

  1. Hayashi H, Sugio K, Matsumata T, Adachi E, Urata K, Tanaka S, Sugimachi K. The mutation of codon 249 in the p53 gene is not specific in Japanese hepatocellular carcinoma. Liver, 13(5): 279-81, 1993 1993;

  2. Toh Y, Liu Y, Tanaka S, Mori R. Nucleotide sequence of the major DNA-binding protein gene of herpes simplex virus type 2 and a comparison with the type 1. Archives of Virology, 129(1-4): 183-96, 1993 1993;

  3. Toh Y, Tanaka S, Liu Y, Hidaka Y, Mori R. Molecular characterization of naturally occurring glycoprotein C-negative herpes simplex virus type 1. Archives of Virology, 129(1-4): 119-30, 1993 1993;

  4. Tanaka S, Toh Y, Mori R. Molecular analysis of a neurovirulent herpes simplex virus type 2 strain with reduced thymidine kinase activity. Archives of Virology, 131: 61-73, 1993 1993;

  5. Tanaka S, Toh Y, Adachi E, Matsumata T, Mori R, Sugimachi K. Tumor progression in hepatocellular carcinoma may be mediated by p53 mutation. Cancer Research, 53: 2884-7, 1993 1993;

  1. Toh Y, Kuwano H, Tanaka S, Baba K, Matsuda H, Sugimachi K, Mori R. Detection of human papillomavirus DNA in esophageal carcinoma in Japan by polymerase chain reaction. Cancer, 70(9): 2234-8, 1992 1992;

  2. Tanaka S, Toh Y, Mori R, Komori K, Okadome K, Sugimachi K. Possible role of cytomegalovirus in the pathogenesis of inflammatory aortic diseases. Journal of Vascular Surgery, 16(2): 274-9, 1992 1992;

  3. Tanaka S, Toh Y, Minagawa H, Mori R, Sugimachi K, Minamishima Y. Reactivation of cytomegalovirus in patients with cirrhosis: analysis of 122 cases. Hepatology, 16(6): 1409-14, 1992 1992;

  1. Gao D, Herman JG, Cui H, Jen J, Fuks F, Brock MV, Ushijima T, Croce C, Akiyama Y, Guo M.: Meeting Report of the Fifth International Cancer Epigenetics Conference in Beijing, China, October 2016. Epigenomics. 2017.07; 9 (7): 937-941. ( PubMed , DOI )

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