A major goal in the field of comprehensive pathology is to understand and overcome many intractable diseases such as leukaemia, lymphomas and tumours. In research, the patient is the starting point for research and the goal of research is also to help the patient. We share the motivation to help and support patients across disciplines, from sequencing, computation and drug discovery, while valuing the classical approach of pathology = sectioning, utilising the foundation of pathological diagnosis to determine the disease and its severity, and we all work together to help and support patients. We are conducting research by incorporating a wide variety of science and technology. We share the 'desire to overcome disease = pathology that helps' across all generations, from staff to students. The real world at the bedside is one in which the same diagnosis can lead to different disease states and different responses to treatment. The importance of this system is to perform comprehensive measurements from the individual, connecting multiple layers of tissues/organs, cells, proteins, genes, metabolites, etc., and to find the essence of the disease and weaknesses in the disease from the data. Every staff member brings his or her own area of specialisation to the table, with each disease they wish to understand and each patient they wish to help in mind. We don't just work in the world of pathology, we work with many collaborators and encourage you to learn from them. Whether you are an undergraduate, postgraduate or doctor, you will also be a link between knowing and seeing the world and meeting amazing people. We also collaborate with the business development world to develop new treatments and bring them to patients, both nationally and internationally. We will also introduce you to our collaborators, so doing research while moving between medicine, dentistry and various other areas may be a good way to broaden your horizons, deepen your research and realise your dreams.

1. reproduction of human blood, immunity and disease As mentioned above, each patient has a different disease and a different immune system that tries to suppress it. Immunity is created from haematopoietic stem cells, and while reproducing this process in mice, we are researching what genes are needed to create a strong immunity, how leukaemia develops in the bones and spreads throughout the body, and what treatments can stop it. Diverse ideas and research tools are needed for research that can help. 2. understanding leukaemia relapse and developing treatments Our major goal is to eradicate 'relapse', where leukaemia cells, once reduced by chemotherapy and other treatments, reappear. To achieve this, we find the cells that cause the relapse, identify therapeutic targets in them and create a treatment. We have been working on these efforts together with the wishes of a large number of patients. We have a continuum of research to track down leukaemia, and as we proceed, we also have the desire to learn about changing technologies and build even better teamwork. 3. visualisation of the bone marrow microenvironment Pathological assessment of the bone marrow microenvironment in human bone marrow What is needed to capture the bone marrow microenvironment as it is known in haematology with optical microscopy? We will also approach this from a molecular biological aspect. Construction of the bone marrow microenvironment using random mutations - Understanding cell-cell interactions in the cancer microenvironment - While many previous reports on the 'cancer microenvironment' have mainly focused on poor prognosis cancers themselves, this research team has comprehensively investigated the mechanism of induction of drug resistance by tumour peritumour support cells. In contrast, the research team established a new CRISPR screening method*3 to comprehensively elucidate the mechanism of drug resistance induction by per tumour support cells. Understanding treatment resistance in disease using CRISPR-Cas Associate Professor Kurata was one of the first to learn about CRISPR and has taken an international leadership role. He is taking on challenges that he has wanted to solve for many years but has not been able to do so, such as tumour resistance to treatment. Postgraduate students and young pathologists are also successfully including CRISPR in their respective research topics to improve their research. 4. deepening pathology and medicine for a wide range of diseases, including breast cancer, pancreatic endocrine tumours, endometriosis, liposarcoma and malignant mesothelioma. 5. visualisation of disease cell/stromal relationships.

Undergraduate education: Education is provided throughout the four years from the first grade to the fourth grade of specialized courses through the general pathology, each theory practice, PBL, block type learning, comprehensive diagnostics practice, BSL, and the like. The program is implemented in cooperation with the human pathology department, hospital pathology department, molecular pathology department, difficult research neuropathology department, and dentistry oral pathology course. At the case study meeting, CPE, which is held at the end of each discussion practice, a small number of students are in charge of one case, give presentations, and promote understanding of pathology through case experience.

Post-graduate education: Training of pathological, anatomy and surgical pathology for the purpose of acquiring the qualification of a pathological society-certified physician, as well as training in related hospitals. Through CPC and case study meetings with clinical departments, the aim is to deepen their understanding of clinical medicine. Regarding research, in addition to the usual pathological methods, we will use them according to the theme of each person such as immunopathology, virology, biochemistry and molecular biology methods, so that we can conduct advanced research.

I the university hospital, surgical materials, biopsy materials, and various organs obtained by pathological dissection are subjected to immunohistological technic in addition to the usual morphological methods.

To improve diagnostic accuracy, the methods of molecular pathology are also applied.