システム発生・再生医学

247  件  
※ 登録方法の違いにより重複して表示されている場合があります。

  1. Homma H, Ngo KX, Yoshioka Y, Tanaka H, Inotsume M, Fujita K, Ando T, Okazawa H: PQBP3/NOL7 is an intrinsically disordered protein. Biochem Biophys Res Commun. 2024.12; 736 150453. ( PubMed , DOI )

  2. Yoshioka Y, Huang Y, Jin X, Ngo KX, Kumaki T, Jin M, Toyoda S, Takayama S, Inotsume M, Fujita K, Homma H, Ando T, Tanaka H, Okazawa H: PQBP3 prevents senescence by suppressing PSME3-mediated proteasomal Lamin B1 degradation. EMBO J. 2024.09; 43 (18): 3968-3999. ( PubMed , DOI )

  3. Ryo Nakamichi, Hiroshi Asahara: The role of mechanotransduction in tendon. J Bone Miner Res. 2024.08; 39 (7): 814-820. ( PubMed , DOI )

  4. Takahide Matsushima, Asahara Hiroshi: Molecular mechanisms of mechanosensing and plasticity of tendons and ligaments. J Biochem. 2024.05; ( PubMed , DOI )

  5. Lisa Yagasaki, Tomoki Chiba, Ryota Kurimoto, Mitsuyo Nakajima, Takanori Iwata, Hiroshi Asahara: The essential role of Mkx in periodontal ligament on the metabolism of alveolar bone and cementum Regen Ther. 2024.03; 25 186-193. ( PubMed , DOI )

  1. Naoto Washihira, Mika Murakami, Miho Nakamura, Sho Fujii, Takahide Matsushima, Hiroshi Asahara, Akio Kishida, Tadao Tanabe, Tsuyoshi Kimura, Mako Kobayashi, Masaya Yamamoto: Application of a genetically engineered macrophage cell line for evaluating cellular effects of UV/US-treated poly(ethylene terephthalate) microplastics. Colloids and Surface B: Biointerfaces. 2023.12; 234 113735. ( PubMed , DOI )

  2. Yoshioka Y, Taniguchi JB, Homma H, Tamura T, Fujita K, Inotsume M, Tagawa K, Misawa K, Matsumoto N, Nakagawa M, Inoue H, Tanaka H, Okazawa H: AAV-mediated editing of PMP22 rescues Charcot-Marie-Tooth disease type 1A features in patient-derived iPS Schwann cells. Commun Med (Lond). 2023.11; 3 (1): 170. ( PubMed , DOI )

  3. Mengjiao Li, Tatsunori Nishimura, Yasuto Takeuchi, Tsunaki Hongu, Yuming Wang, Daisuke Shiokawa, Kang Wang, Haruka Hirose, Asako Sasahara, Masao Yano, Satoko Ishikawa, Masafumi Inokuchi, Tetsuo Ota, Masahiko Tanabe, Kei-Ichiro Tada, Tetsu Akiyama, Xi Cheng, Chia-Chi Liu, Toshinari Yamashita, Sumio Sugano, Yutaro Uchida, Tomoki Chiba, Hiroshi Asahara, Masahiro Nakagawa, Shinya Sato, Yohei Miyagi, Teppei Shimamura, Luis Augusto E Nagai, Akinori Kanai, Manami Katoh, Seitaro Nomura, Ryuichiro Nakato, Yutaka Suzuki, Arinobu Tojo, Dominic C Voon, Seishi Ogawa, Koji Okamoto, Theodoros Foukakis, Noriko Gotoh: FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters. J Clin Invest. 2023.11; 133 (22): ( PubMed , DOI )

  4. Jaehoon Shin, Shigeru Miyaki, Hiroshi Asahara, Takayuki Akimoto: MicroRNA-140 is not involved in sepsis-induced muscle atrophy. Am J Physiol Cell Physiol. 2023.08; 325 (2): C509-C518. ( PubMed , DOI )

  5. Yudai Ono, Saundra Schlesinger, Kanako Fukunaga, Shinsei Yambe, Tempei Sato, Takako Sasaki, Chisa Shukunami, Hiroshi Asahara, Masafumi Inui: Scleraxis-lineage cells are required for correct muscle patterning. Development. 2023.05; 150 (10): ( PubMed , DOI )

  6. Maiko Inotsume, Tomoki Chiba, Takahide Matsushima, Ryota Kurimoto, Mitsuyo Nakajima, Tomomi Kato, Kana Shishido, Lin Liu, Koichi Kawakami, Hiroshi Asahara: One-step generation of mice with gene editing by Tol2 transposon-dependent gRNA delivery. FEBS Lett. 2023.03; ( PubMed , DOI )

  7. Hiroto Yamamoto, Yutaro Uchida, Ryota Kurimoto, Tomoki Chiba, Takahide Matsushima, Yoshiaki Ito, Maiko Inotsume, Kohei Miyata, Kenta Watanabe, Masaki Inada, Naoki Goshima, Tokujiro Uchida, Hiroshi Asahara: RNA-binding protein LIN28A upregulates transcription factor HIF1α by posttranscriptional regulation via direct binding to UGAU motifs. J Biol Chem. 2023.01; 299 (1): 102791. ( PubMed , DOI )

  1. Tomohiko Murakami, Yoshifumi Takahata, Kenji Hata, Kosuke Ebina, Katsutoshi Hirose, Lerdluck Ruengsinpinya, Yuri Nakaminami, Yuki Etani, Sachi Kobayashi, Takashi Maruyama, Hiroyasu Nakano, Takehito Kaneko, Satoru Toyosawa, Hiroshi Asahara, Riko Nishimura: Semaphorin 4D induces articular cartilage destruction and inflammation in joints by transcriptionally reprogramming chondrocytes. Sci Signal. 2022.11; 15 (758): eabl5304. ( PubMed , DOI )

  2. Ryo Nakamichi, Hiroshi Asahara: Motion-capture Analysis of Mice Using a Video Recorded on an iPhone Camera. Bio Protoc. 2022.11; 12 (21): ( PubMed , DOI )

  3. Takayoshi Sasako, Toshihiro Umehara, Kotaro Soeda, Kazuma Kaneko, Miho Suzuki, Naoki Kobayashi, Yukiko Okazaki, Miwa Tamura-Nakano, Tomoki Chiba, Domenico Accili, C Ronald Kahn, Tetsuo Noda, Hiroshi Asahara, Toshimasa Yamauchi, Takashi Kadowaki, Kohjiro Ueki: Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice. Nat Commun. 2022.10; 13 (1): 5655. ( PubMed , DOI )

  4. Yuta Fujii, Lin Liu, Lisa Yagasaki, Maiko Inotsume, Tomoki Chiba, Hiroshi Asahara: Cartilage Homeostasis and Osteoarthritis. Int J Mol Sci. 2022.06; 23 (11): ( PubMed , DOI )

  5. Ryo Nakamichi, Shang Ma, Takayuki Nonoyama, Tomoki Chiba, Ryota Kurimoto, Hiroki Ohzono, Merissa Olmer, Chisa Shukunami, Noriyuki Fuku, Guan Wang, Errol Morrison, Yannis P Pitsiladis, Toshifumi Ozaki, Darryl D'Lima, Martin Lotz, Ardem Patapoutian, Hiroshi Asahara: The mechanosensitive ion channel PIEZO1 is expressed in tendons and regulates physical performance. Sci Transl Med. 2022.06; 14 (647): eabj5557. ( PubMed , DOI )

  6. Manabu Kawata, Takeshi Teramura, Philip Ordoukhanian, Steven R Head, Padmaja Natarajan, Aishwarya Sundaresan, Merissa Olmer, Hiroshi Asahara, Martin K Lotz: Krüppel-like factor-4 and Krüppel-like factor-2 are important regulators of joint tissue cells and protect against tissue destruction and inflammation in osteoarthritis. Ann Rheum Dis. 2022.05; ( PubMed , DOI )

  7. Kaho Takada, Tomoki Chiba, Takayuki Miyazaki, Lisa Yagasaki, Ryo Nakamichi, Takanori Iwata, Keiji Moriyama, Hiroyuki Harada, Hiroshi Asahara: Single Cell RNA Sequencing Reveals Critical Functions of Mkx in Periodontal Ligament Homeostasis Front Cell Dev Biol. 2022.02; 10 795441. ( PubMed , DOI )

  8. Hiroki Tsutsumi, Ryota Kurimoto, Ryo Nakamichi, Tomoki Chiba, Takahide Matsushima, Yuta Fujii, Risa Sanada, Tomomi Kato, Kana Shishido, Yuriko Sakamaki, Tsuyoshi Kimura, Akio Kishida, Hiroshi Asahara: Generation of a tendon-like tissue from human iPS cells. J Tissue Eng. 2022.01; 13 20417314221074018. ( PubMed , DOI )

  1. Miyazaki Takayuki, Kurimoto Ryota, Chiba Tomoki, Matsushima Takahide, Nakamichi Ryo, Tsutsumi Hiroki, Takada Kaho, Yagasaki Lisa, Kato Tomomi, Shishido Kana, Kobayashi Yukiho, Matsumoto Tsutomu, Moriyama Keiji, Asahara Hiroshi: Mkxは破骨細胞の誘導を介して歯科矯正による歯の移動を制御する(Mkx regulates the orthodontic tooth movement via osteoclast induction) Journal of Bone and Mineral Metabolism. 2021.09; 39 (5): 780-786. ( 医中誌 )

  2. Lin Liu, Hiroyuki Koike, Takehito Ono, Shinichiro Hayashi, Fujimi Kudo, Atsushi Kaneda, Hiroyuki Kagechika, Ichiro Manabe, Tomoki Nakashima, Yumiko Oishi: Identification of a KLF5-dependent program and drug development for skeletal muscle atrophy. Proc Natl Acad Sci U S A. 2021.08; 118 (35): ( PubMed , DOI )

  3. Yoshiaki Ito, Tokio Matsuzaki, Fumiaki Ayabe, Sho Mokuda, Ryota Kurimoto, Takahide Matsushima, Yusuke Tabata, Maiko Inotsume, Hiroki Tsutsumi, Lin Liu, Masahiro Shinohara, Yoko Tanaka, Ryo Nakamichi, Keiichiro Nishida, Martin K Lotz, Hiroshi Asahara: Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis. Nat Commun. 2021.07; 12 (1): 4148. ( PubMed , DOI )

  4. Takayuki Miyazaki, Ryota Kurimoto, Tomoki Chiba, Takahide Matsushima, Ryo Nakamichi, Hiroki Tsutsumi, Kaho Takada, Lisa Yagasaki, Tomomi Kato, Kana Shishido, Yukiho Kobayashi, Tsutomu Matsumoto, Keiji Moriyama, Hiroshi Asahara: Mkx regulates the orthodontic tooth movement via osteoclast induction. J Bone Miner Metab. 2021.05; 39 (5): 780-786. ( PubMed , DOI )

  5. Yutaro Uchida, Takahide Matsushima, Ryota Kurimoto, Tomoki Chiba, Yuki Inutani, Hiroshi Asahara: Identification of chemical compounds regulating PD-L1 by introducing HiBiT-tagged cells. FEBS Lett. 2021.03; 595 (5): 563-576. ( PubMed , DOI )

  6. Chiba T, Kurimoto R, Matsushima T, Ito Y, Nakamichi R, Lotz M, Asahara H: MicroRNA Expression Profiling, Target Identification, and Validation in Chondrocytes. Methods in molecular biology (Clifton, N.J.). 2021; 2245 151-166. ( PubMed , DOI )

  7. Keiko Itano,KojiOchiai, Takahide Matsushima,Hiroshi Asahara and Koichi Takahashi: Automation of Foci-Cell-State Judgement with Regression Models Transactions of the Institute of Systems, Control and Information Engineers. 2021; 34 (3): 69-80. ( DOI )

  1. Hiroto Yamamoto, Yutaro UchidaI, Tomoki Chiba, Ryota Kurimoto,Takahide Matsushima, Maiko Inotsume, Chihiro Ishikawa, Haiyan Li, Takashi Shiga, Masafumi Muratani, Tokujiro Uchida, Hiroshi Asahara: Transcriptome analysis of sevoflurane exposure effects at the different brain regions PLOS ONE. 2020.10;

  2. Kwang Il Lee, Ramya Gamini, Merissa Olmer, Yasunari Ikuta, Joe Hasei, Jihye Baek, Oscar Alvarez-Garcia, Shawn P Grogan, Darryl D D'Lima, Hiroshi Asahara, Andrew I Su, Martin K Lotz: Mohawk is a transcription factor that promotes meniscus cell phenotype and tissue repair and reduces osteoarthritis severity. Sci Transl Med. 2020.10; 12 (567): 7967. ( PubMed , DOI )

  3. Kurimoto R, Chiba T, Ito Y, Matsushima T, Yano Y, Miyata K, Yashiro Y, Suzuki T, Tomita K, Asahara H: The tRNA pseudouridine synthase TruB1 regulates the maturation of let-7 miRNA. The EMBO journal. 2020.09; e104708. ( PubMed , DOI )

  4. Ryo Nakamichi, Ryota Kurimoto, Yusuke Tabata, Hirosi Asahara: Transcriptional, epigenetic and microRNA regulation of growth plate. Bone. 2020.08; 137 115434. ( PubMed , DOI )

  5. Ryo Nakamichi, Hiroshi Asahara: Regulation of tendon and ligament differentiation. Bone. 2020.08; 115609. ( PubMed , DOI )

  6. Kurimoto R, Sakurai K, Motoori K, Suda A: A case of COVID-19 with the atypical CT finding. Clinical case reports. 2020.07; ( PubMed , DOI )

  7. Mokuda S, Nakamichi R, Ito Y, Asahara H: Genetic, Epigenetic, and MicroRNA Regulation of Osteoarthritis Encyclopedia of Bone Biology, vol.[1]. 2020.06; 1 641-651.

  8. Tempei Sato, Kensuke Kataoka, Yoshiaki Ito, Shigetoshi Yokoyama, Masafumi Inui, Masaki Mori, Satoru Takahashi, Keiichi Akita, Shuji Takada, Hiroe Ueno-Kudoh, Hiroshi Asahara: Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates Elife. 2020.05; 9 ( PubMed , DOI )

  9. Ryo Nakamichi, Hiroshi Asahara: The transcription factors regulating intervertebral disc development. JOR Spine. 2020.03; 3 (1): e1081. ( PubMed , DOI )

  10. Eric Gracey, Arne Burssens, Isabelle Cambré, Georg Schett, Rik Lories, Iain B McInnes, Hiroshi Asahara, Dirk Elewaut: Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis. Nat Rev Rheumatol. 2020.02; 16 (4): 193-207. ( PubMed , DOI )

  11. Yuki Yano, Tomoki Chiba, Hiroshi Asahara: Analysis of the Mouse Y Chromosome by Single-Molecule Sequencing With Y Chromosome Enrichment. Front Genet. 2020; 11 406. ( PubMed , DOI )

  12. Kensuke Kataoka, Ryota Kurimoto, Hiroki Tsutsumi, Tomoki Chiba, Tomomi Kato, Kana Shishido, Mariko Kato, Yoshiaki Ito, Yuichiro Cho, Osamu Hoshi, Ayako Mimata, Yuriko Sakamaki, Ryo Nakamichi, Martin K Lotz, Keiji Naruse, Hiroshi Asahara: In vitro Neo-Genesis of Tendon/Ligament-Like Tissue by Combination of Mohawk and a Three-Dimensional Cyclic Mechanical Stretch Culture System Front Cell Dev Biol. 2020; 8 307. ( PubMed , DOI )

  13. Yamamoto H, Uchida Y, Chiba T, Kurimoto R, Matsushima T, Inotsume M, Ishikawa C, Li H, Shiga T, Muratani M, Uchida T, Asahara H: Transcriptome analysis of sevoflurane exposure effects at the different brain regions. PloS one. 2020; 15 (12): e0236771. ( PubMed , DOI )

  1. Carmen Adriaens, Florian Rambow, Greet Bervoets, Toomas Silla, Mari Mito, Tomoki Chiba, Hiroshi Asahara, Tetsuro Hirose, Shinichi Nakagawa, Torben Heick Jensen, Jean-Christophe Marine: The long noncoding RNA NEAT1_1 is seemingly dispensable for normal tissue homeostasis and cancer cell growth. RNA. 2019.12; 25 (12): 1681-1695. ( PubMed , DOI )

  2. Momo Isobe, Hikaru Toya, Mari Mito, Tomoki Chiba, Hiroshi Asahara, Tetsuro Hirose, Shinichi Nakagawa: Forced isoform switching of Neat1_1 to Neat1_2 leads to the loss of Neat1_1 and the hyperformation of paraspeckles but does not affect the development and growth of mice. RNA. 2019.12; ( PubMed , DOI )

  3. Yutaro Uchida, Tomoki Chiba, Ryota Kurimoto, Hiroshi Asahara: Post-transcriptional regulation of inflammation by RNA-binding proteins via cis-elements of mRNAs. J. Biochem.. 2019.11; 166 (5): 375-382. ( PubMed , DOI )

  4. Uchida Yutaro, Chiba Tomoki, Kurimoto Ryota, Asahara Hiroshi: RNA結合蛋白質によるmRNAのシスエレメントを介した炎症の転写後調節(Post-transcriptional regulation of inflammation by RNA-binding proteins via cis-elements of mRNAs) The Journal of Biochemistry. 2019.11; 166 (5): 375-382. ( 医中誌 )

  5. Kurimoto Ryota, Tsutsumi Hiroki, Uchida Yutaro, Asahara Hiroshi: New regulatory mechanism of tumor suppressor microRNA let-7s (comprehensive approach for tumor suppressors in vitro) ANNALS OF ONCOLOGY. 2019.10; 30 ( DOI )

  6. Yamashita Satoshi, Kataoka Kensuke, Yamamoto Hiroto, Kato Tomoko, Hara Satoshi, Yamaguchi Katsushi, Renard-Guillet Claire, Katou Yuki, Shirahige Katsuhiko, Ochi Haruki, Ogino Hajime, Uchida Tokujiro, Inui Masafumi, Takada Shuji, Shigenobu Shuji, Asahara Hiroshi: Comparative analysis demonstrates cell type-specific conservation of SOX9 targets between mouse and chicken SCIENTIFIC REPORTS. 2019.08; 9 (1): 12560. ( PubMed , DOI )

  7. Takayoshi Sasako, Mitsuru Ohsugi, Naoto Kubota, Shinsuke Itoh, Yukiko Okazaki, Ai Terai, Tetsuya Kubota, Satoshi Yamashita, Kunio Nakatsukasa, Takumi Kamura, Kaito Iwayama, Kumpei Tokuyama, Hiroshi Kiyonari, Yasuhide Furuta, Junji Shibahara, Masashi Fukayama, Kenichiro Enooku, Kazuya Okushin, Takeya Tsutsumi, Ryosuke Tateishi, Kazuyuki Tobe, Hiroshi Asahara, Kazuhiko Koike, Takashi Kadowaki, Kohjiro Ueki: Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism. Nat Commun. 2019.02; 10 (1): 947. ( PubMed , DOI )

  8. Kita M, Nakae J, Kawano Y, Asahara H, Takemori H, Okado H, Itoh H: Zfp238 Regulates the Thermogenic Program in Cooperation with Foxo1. iScience. 2019.02; 12 87-101. ( PubMed , DOI )

  1. Mitsumura T, Ito Y, Chiba T, Matsushima T, Kurimoto R, Tanaka Y, Kato T, Uchida K, Ito T, Yamamoto K, Eishi Y, Kitagawa M, Miyazaki Y, Inase N, Asahara H: Ablation of miR-146b in mice causes hematopoietic malignancy. Blood advances. 2018.12; 2 (23): 3483-3491. ( PubMed , DOI )

  2. Takeshi Saito, Satoshi Hara, Tomoko Kato, Moe Tamano, Akari Muramatsu, Hiroshi Asahara, Shuji Takada: A tandem repeat array in IG-DMR is essential for imprinting of paternal allele at the Dlk1-Dio3 domain during embryonic development. Hum. Mol. Genet.. 2018.09; 27 (18): 3283-3292. ( PubMed , DOI )

  3. Yusuke Mochizuki, Tomoki Chiba, Kensuke Kataoka, Satoshi Yamashita, Tempei Sato, Tomomi Kato, Kenji Takahashi, Takeshi Miyamoto, Masashi Kitazawa, Tomohisa Hatta, Tohru Natsume, Shinro Takai, Hiroshi Asahara: Combinatorial CRISPR/Cas9 Approach to Elucidate a Far-Upstream Enhancer Complex for Tissue-Specific Sox9 Expression. Dev. Cell. 2018.08; 46 (6): 794-806.e6. ( PubMed , DOI )

  4. Alvarez-Garcia O, Matsuzaki T, Olmer M, Miyata K, Mokuda S, Sakai D, Masuda K, Asahara H, Lotz MK: FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration. Aging Cell. 2018.07; e12800. ( PubMed , DOI )

  5. Masafumi Inui, Sho Mokuda, Tempei Sato, Moe Tamano, Shuji Takada, Hiroshi Asahara: Dissecting the roles of miR-140 and its host gene. Nat. Cell Biol.. 2018.05; 20 (5): 516-518. ( PubMed , DOI )

  6. Nakamichi R, Kataoka K, Asahara H: Essential role of Mohawk for tenogenic tissue homeostasis including spinal disc and periodontal ligament. Modern rheumatology. 2018.05; 1-8. ( PubMed , DOI )

  7. Tokio Matsuzaki, Oscar Alvarez-Garcia, Sho Mokuda, Keita Nagira, Merissa Olmer, Ramya Gamini, Kohei Miyata, Yukio Akasaki, Andrew I Su, Hiroshi Asahara, Martin K Lotz: FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis. Sci Transl Med. 2018.02; 10 (428): ( PubMed , DOI )

  8. Kataoka K, Matsushima T, Ito Y, Sato T, Yokoyama S, Asahara H: Bhlha9 regulates apical ectodermal ridge formation during limb development. Journal of bone and mineral metabolism. 2018.01; 36 (1): 64-72. ( PubMed , DOI )

  9. Kataoka K, Matsushima T, Ito Y, Sato T, Yokoyama S, Asahara H: Bhlha9 regulates apical ectodermal ridge formation during limb development. JBMM. 2018.01; 36 (1): 64-72. ( PubMed , DOI )

  1. kuda K, Kobayashi S, Fukaya M, Watanabe A, Murakami T, Hagiwara M, Sato T, Ueno H, Ogonuki N, Komano-Inoue S, Manabe H, Yamaguchi M, Ogura A, Asahara H, Sakagami H, Mizuguchi M, Manabe T, Tanaka T: CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility. Neurobiol Dis. 2017.10; 106 158-170. ( PubMed , DOI )

  2. Asahara H*, Inui M*, Lotz M: Tendons and Ligaments: Connecting Developmental Biology to Musculoskeletal Disease Pathogenesis. JBMR. 2017.09; 32 (9): 1773-1782. ( PubMed )

  3. Shiba D, Mizuno H, Yumoto A, Shimomura M, Kobayashi H, Morita H, Shimbo M, Hamada M, Kudo T, Shinohara M, Asahara H, Shirakawa M, Takahashi S.: Development of new experimental platform 'MARS'-Multiple Artificial-gravity Research System-to elucidate the impacts of micro/partial gravity on mice. Sci Rep. 2017.09; 7 (1): 10837. ( PubMed , DOI )

  4. Miyata K, Naito M, Miyata T, Mokuda S, Asahara H*: Bisulfite Sequencing for DNA Methylation Analysis of Primary Muscle Stem Cells. Methods Mol Biol. 2017.08; (1668): 3-13. ( PubMed )

  5. Kurimoto R, Ebata T, Iwasawa S, Ishiwata T, Tada Y, Tatsumi K, Takiguchi Y: Pirfenidone may revert the epithelial-to-mesenchymal transition in human lung adenocarcinoma. Oncology letters. 2017.07; 14 (1): 944-950. ( PubMed , DOI )

  6. Ogino H, Hisanaga A, Kohno T, Kondo Y, Okumura K, Kamei T, Sato T, Asahara H, Tsuiji H, Fukata M, Hattori M: Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin. J Neurosci. 2017.05; 37 (12): 3181-3191. ( PubMed , DOI )

  7. Oba A, Shimada S, Akiyama Y, Nishikawaji T, Mogushi K, Ito H, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Asahara H, Kaida A, Miura M, Tanabe M, Tanaka S: ARID2 modulates DNA damage response in human hepatocellular carcinoma cells. J Hepato. 2017.05; 66 (5): 942-951. ( PubMed , DOI )

  8. Yokoyama S, Furukawa S, Kitada S, Mori M, Saito T, Kawakami K, Izpisua Belmonte JC, Kawakami Y, Ito Y, Sato T, AsaharaH: Analysis of transcription factors expressed at the anterior mouse limb bud. PLoS One. 2017.05; 12 (5): e0175673. ( PubMed , DOI )

  9. Kurimoto R, Iwasawa S, Ebata T, Ishiwata T, Tada Y, Tatsumi K, Takiguchi Y: Pirfenidone in reversion of the epithelial-to-mesenchymal transition in human lung adenocarcinoma. Oncology Letters. 2017.05; 14 (1): 944-950.

  10. Ito Y, Inoue A, Seers T, Hato Y, Igarashi A, Toyama T, Taganov K, Boldin M, AsaharaH: Identification of targets of tumor suppressor microRNA-34a using a reporter library system. Proc Natl Acad Sci U S A. 2017.04; 114 (15): 3927-3932. ( PubMed , DOI )

  11. Yachie Nozomu, Natsume Tohru, Takahashi Koichi, Katayama Toshiaki, Sakurada Takeshi, Kanda Genki N., Takagi Eiji, Hirose Takako, Katsura Tatsuo, Moriya Tetsuo, Kitano Hiroaki, Tsujii Junichi, Natsume Tohru, Shiraki Tomoyuki, Kariyazaki Hirokazu, Kamei Motohisa, Abe Noriko, Fukuda Takuya, Sawada Yukiko, Hashiguchi Yukio, Matsukuma Kenji, Murai Shinji, Sasaki Naoyuki, Ipposhi Tatsuro, Urabe Hideo, Kudo Taku, Umeno Makoto, Ono Seiki, Miyauchi Kohei, Nakamura Miki, Kizaki Takahiro, Suyama Takashi, Hatta Tomohisa, Natsume Tohru, Ohta Tazro, Takahashi Koichi, Ozawa Yosuke, Yachie Nozomu, Sakurada Takeshi, Matsukuma Kenji, Murai Shinji, Ihara Shoji, Tamaki Satoshi, Antezana Erick, Garcia-Castro Alexander, Perret Jean-Luc, Ishiguro Soh, Mori Hideto, Evans-Yamamoto Daniel, Masuyama Nanami, Tomita Masaru, Tsujii Junichi, Katayama Toshiaki, Kitano Hiroaki, Hatta Tomohisa, Matsumoto Masaki, Nakayama Hiroshi, Shirasawa Ayaka, Shimbo Kazutaka, Yamada Naoyuki, Nakayama Keiichi I., Natsume Tohru, Shimizu Takatsune, Saya Hideyuki, Yamashita Satoshi, Matsushima Takahide, Asahara Hiroshi, Eguchi Hidetoshi, Mikamori Manabu, Mori Masaki: Robotic crowd biology with Maholo LabDroids NATURE BIOTECHNOLOGY. 2017.04; 35 (4): 310-312. ( DOI )

  12. Emiko Sakaida, Takahiro Ebata, Shunichiro Iwasawa, Ryota Kurimoto, Sachiko Yonemori, Satoshi Ota, Yukio Nakatani, Ikuo Sekine, Yuichi Takiguchi: Potential Activity of Amrubicin as a Salvage Therapy for Merkel Cell Carcinoma. Internal Medicine. 2017.03; 56 (5): 567-570.

  13. Matsui-Hasumi A, Sato Y, Uto-Konomi A, Yamashita S, Uehori J, Yoshimura A, Yamashita M, Asahara H, Suzuki S, Kubo M: E3 ubiquitin ligases SIAH1/2 regulate hypoxia-inducible factor-1 (HIF-1)-mediated Th17 cell differentiation. International immunology. 2017.03; 29 (3): 133-143. ( PubMed , DOI )

  14. Kayama Tomohiro, Mori Masaki, Ito Yoshiaki, Matsushima Takahide, Nakamichi Ryo, Suzuki Hidetsugu, Ichinose Shizuko, Saito Mitsuru, Marumo Keishi, Asahara Hiroshi: コラーゲン線維の成熟における腱/靱帯特異的Mohawk(Mkx)遺伝子の機械調節転写ネットワークの関与(Mechanoregulatory transcriptional network converges to tendon/ligament-specific Mohawk(Mkx) gene for collagen fiber maturation) 日本整形外科学会雑誌. 2017.03; 91 (3): S788. ( 医中誌 )

  15. Sakaida Emiko, Ebata Takahiro, Iwasawa Shunichiro, Kurimoto Ryota, Yonemori Sachiko, Ota Satoshi, Nakatani Yukio, Sekine Ikuo, Takiguchi Yuichi: メルケル細胞癌に対するサルベージ療法としてのアムルビシンの潜在的活性(Potential Activity of Amrubicin as a Salvage Therapy for Merkel Cell Carcinoma) Internal Medicine. 2017.03; 56 (5): 567-570. ( 医中誌 )

  16. Hasei J, Teramura T, Takehara T, Onodera Y, Horii T, Olmer M, Hatada I, Fukuda K, Ozaki T, Lotz M, Asahara H: TWIST1 induces MMP3 expression through up-regulating DNA hydroxymethylation and promotes catabolic responses in human chondrocytes. Sci Rep. 2017.02; 7 42990. ( PubMed , DOI )

  17. Saito T, Hara S, Tamano M, Asahara H, Takada S: Deletion of conserved sequences in IG-DMR at Dlk1-Gtl2 locus suggests their involvement in expression of paternally expressed genes in mice. J Reprod Dev. 2017.02; 63 (1): 101-109. ( PubMed , DOI )

  18. Nakasuji T, Ogonuki N, Chiba T, Kato T, Shiozawa K, Yamatoya K, Tanaka H, Kondo T, Miyado K, Miyasaka N, Kubota T, Ogura A, Asahara H: Complementary critical functions of Zfy1 and Zfy2 in mouse spermatogenesis and reproductiontran PLoS Genetics. 2017.01; 13 (1): e1006578.

  19. Otero M, Peng H, El Hachem K, Culley KL, Wondimu EB, Quinn J, Asahara H, Tsuchimochi K, Hashimoto K, Goldring MB: ELF3 modulates type II collagen gene (COL2A1) transcription in chondrocytes by Inhibiting SOX9-CBP/p300-driven histone acetyltransferase activity. Connect Tissue Res. 2017.01; 58 (1): 15-26. ( PubMed , DOI )

  20. Koda N, Sato T, Shinohara M, Ichinose S, Ito Y, Nakamichi R, Kayama T, Kataoka K, Suzuki H, Moriyama K, Asahara H: The transcription factor mohawk homeobox regulates homeostasis of the periodontal ligament. Development (Cambridge, England). 2017.01; 144 (2): 313-320. ( PubMed , DOI )

  21. Sakaida E, Ebata T, Iwasawa S, Kurimoto R, Yonemori S, Ota S, Nakatani Y, Sekine I, Takiguchi Y: Potential Activity of Amrubicin as a Salvage Therapy for Merkel Cell Carcinoma. Internal medicine (Tokyo, Japan). 2017; 56 (5): 567-570. ( PubMed , DOI )

  1. Kurimoto Ryota, Shono Katsuhiro, Onoda Masahiro, Yamamoto Kyohei, Yokota Akira: メトトレキサート治療に関連した関節リウマチ患者のMYC/BCL2ダブルヒットリンパ腫(MYC/BCL2 Double-hit Lymphoma in a Patient with Rheumatoid Arthritis Associated with Methotrexate Treatment) Internal Medicine. 2016.08; 55 (16): 2271-2275. ( 医中誌 )

  2. Ryo Nakamichi, Yoshiaki Ito, Masafumi Inui, Naoko Onizuka, Tomohiro Kayama, Kensuke Kataoka, Hidetsugu Suzuki, Masaki Mori, Masayo Inagawa, Shizuko Ichinose, Martin K Lotz, Daisuke Sakai, Koichi Masuda, Toshifumi Ozaki, Hiroshi Asahara: Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs. Nat Commun. 2016.08; 7 12503. ( PubMed , DOI )

  3. Asahara H*.: Current Status and Strategy of microRNA Research for Cartilage Development and Osteoarthritis Pathogenesis. J Bone Metab. . 2016.08; 23 (3): 121-127. ( PubMed , DOI )

  4. Kurimoto Ryota, Ikeda Kei, Nakagomi Daiki, Nakajima Hiroshi: [18F]FDG-PET/CTで描出された好酸球性筋膜炎(Eosinophilic Fasciitis Illustrated by [18F] FDG-PET/CT) Internal Medicine. 2016.08; 55 (16): 2321-2322. ( 医中誌 )

  5. Naito M, Mori M, Inagawa M, Miyata K, Hashimoto N, Tanaka S, Asahara H.: Dnmt3a Regulates Proliferation of Muscle Satellite Cells via p57Kip2. PLoS Genetics. . 2016.07; 12 (7): e1006167. ( PubMed , DOI )

  6. Hidetsugu Suzuki, Yoshiaki Ito, Masahiro Shinohara, Satoshi Yamashita, Shizuko Ichinose, Akio Kishida, Takuya Oyaizu, Tomohiro Kayama, Ryo Nakamichi, Naoki Koda, Kazuyoshi Yagishita, Martin K Lotz, Atsushi Okawa, Hiroshi Asahara: Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis. Proc. Natl. Acad. Sci. U.S.A.. 2016.07; 113 (28): 7840-7845. ( PubMed , DOI )

  7. Ryota Kurimoto, Shunichiro Iwasawa, Takahiro Ebata, Tsukasa Ishiwata, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Shuhei Koide, Atsushi Iwama, Yuichi Takiguchi: Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation. Int. J. Oncol.. 2016.05; 48 (5): 1825-1836. ( PubMed , DOI )

  8. Shimbo M, Kudo T, Hamada M, Jeon H, Imamura Y, Asano K, Okada R, Tsunakawa Y, Mizuno S, Yagami KI, Ishikawa C, Li H, Shiga T, Ishida J, Hamada J, Murata K, Ishimaru T, Hashimoto M, Fukamizu A, Yamane M, Ikawa M, Morita H, Shinohara M, Asahara H, Akiyama T, Akiyama N, Sasanuma H, Yoshida N, Zhou R, Wang YY, Ito T, Kokubu Y, Noguchi TK, Ishimine H, Kurisaki A, Shiba D, Mizuno H, Shirakawa M, Ito N, Takeda S, Takahashi S.: Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies. Experimental Animals. 2016.05; ( PubMed , DOI )

  9. Kayama T, Mori M, Ito Y, Matsushima T, Nakamichi R, Suzuki H, Ichinose S, Saito M, Marumo K, Asahara H: Gtf2ird1-Dependent Mohawk Expression Regulates Mechanosensing Properties of the Tendon. Molecular and cellular biology. 2016.04; 36 (8): 1297-309. ( PubMed , DOI )

  10. Emiko Sakaida, Shunichiro Iwasawa, Ryota Kurimoto, Takahiro Ebata, Chiaki Imai, Tomoko Oku, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Yuichi Takiguchi: Safety of a short hydration method for cisplatin administration in comparison with a conventional method-a retrospective study. Jpn. J. Clin. Oncol.. 2016.04; 46 (4): 370-377. ( PubMed , DOI )

  11. Sakaida Emiko, Iwasawa Shunichiro, Kurimoto Ryota, Ebata Takahiro, Imai Chiaki, Oku Tomoko, Sekine Ikuo, Tada Yuji, Tatsumi Koichiro, Takiguchi Yuichi: Cisplatin投与におけるshort hydration法の安全性の従来法との比較　後向き研究(Safety of a short hydration method for cisplatin administration in comparison with a conventional method: a retrospective study) Japanese Journal of Clinical Oncology. 2016.04; 46 (4): 370-377. ( 医中誌 )

  12. Tsukasa Ishiwata, Shunichiro Iwasawa, Ryota Kurimoto, Takahiro Ebata, Yuichi Takiguchi: Prophylactic dexamethasone for radiation-induced bone-pain flare. Lancet Oncol.. 2016.02; 17 (2): e39-e40. ( PubMed , DOI )

  13. Kayama T, Mori M, Ito Y, Matsushima T, Nakamichi R, Suzuki H, Ichinose S, Saito M, Marumo K, Asahara H.: Gtf2ird1-dependent Mohawk (Mkx) expression regulates mechanosensing properties of tendon. Mol Cell Biol. 2016.02; ( PubMed , DOI )

  14. Doiguchi M, Nakagawa T, Imamura Y, Yoneda M, Higashi M, Kubota K, Yamashita S, Asahara H, Iida M, Fujii S, Ikura T, Liu Z, Nandu T, Kraus WL, Ueda H, Ito T: SMARCAD1 is an ATP-dependent stimulator of nucleosomal H2A acetylation via CBP, resulting in transcriptional regulation Sci Rep. 2016.02; ( PubMed , DOI )

  15. Ito Y, Mokuda S, Miyata K, Matsushima T, Asahara H.: MicroRNAs in Chronic Inflammation Diseases. Chronic Inflammation (Chapter 6) 2016 Springer Japan. Review. Book.. 2016; ( DOI )

  16. T. Chiba, Y. Ito, H. Asahara.: Post-Transcriptional Gene Regulation by MicroRNA and RNA-Binding Protein Biomedical Sciences. 2016;

  17. Ryota Kurimoto, Kei Ikeda, Daiki Nakagomi, Hiroshi Nakajima: Eosinophilic Fasciitis Illustrated by [(18)F] FDG-PET/CT. Intern. Med.. 2016; 55 (16): 2321-2322. ( PubMed , DOI )

  18. Ryota Kurimoto, Katsuhiro Shono, Masahiro Onoda, Kyohei Yamamoto, Akira Yokota: MYC/BCL2 Double-hit Lymphoma in a Patient with Rheumatoid Arthritis Associated with Methotrexate Treatment. Intern. Med.. 2016; 55 (16): 2271-2275. ( PubMed , DOI )

  1. Yamada K, Saito H, Kondo T, Murakami S, Masuda N, Yamamoto M, Igawa S, Katono K, Takiguchi Y, Iwasawa S, Kurimoto R, Okamoto H, Shimokawa T, Hosomi Y, Takagi Y, Kishi K, Ohba M, Oshita F, Watanabe K: Multicenter Phase II Study of Nedaplatin and Irinotecan for Patients with Squamous Cell Carcinoma of the Lung: Thoracic Oncology Research Group 0910. Anticancer research. 2015.12; 35 (12): 6705-11. ( PubMed )

  2. Ogura Y, Miyake N, Kou I, Iida A, Nakajima M, Takeda K, Fujibayashi S, Shiina M, Okada E, Toyama Y, Iwanami A, Ishii K, Ogata K, Asahara H, Matsumoto N, Nakamura M, Matsumoto M, Ikegawa S: Identification of HOXD4 Mutations in Spinal Extradural Arachnoid Cyst PLoS One. 2015.11; ( PubMed , DOI )

  3. Gernapudi R, Wolfson B, Zhang Y, Yao Y, Yang P, Asahara H, Zhou Q: MicroRNA 140 Promotes Expression of Long Noncoding RNA NEAT1 in Adipogenesis Mol Cell Biol. 2015.10; ( PubMed , DOI )

  4. Ryosuke Tateishi , Nobuko Akiyama , Maki Miyauchi, Riko Yoshinaga, Hiroki Sasanuma, Takashi Kudo, Miki Shimbo, Masahiro Shinohara, Koji Obata, Jun-ichiro Inoue, Masaki Shirakawa, Dai Shiba, Hiroshi Asahara, Nobuaki Yoshida, Satoru Takahashi, Hironobu Morita , Taishin Akiyama: Hypergravity Provokes a Temporary Reduction in CD4+CD8+ Thymocyte Number and a Persistent Decrease in Medullary Thymic Epithelial Cell Frequency in Mice. PLoS One. 2015.10; 10 ( PubMed , DOI )

  5. Matsubara Y, Kato T, Kashimada K, Tanaka H, Zhi Z, Ichinose S, Mizutani S, Morio T, Chiba T, Ito Y, Saga Y, Takada S, Asahara H: TALEN-Mediated Gene Disruption on Y Chromosome Reveals Critical Role of EIF2S3Y in Mouse Spermatogenesis. Stem Cells Dev. 2015.05; 1164-1170. ( PubMed , DOI )

  6. Kurimoto Ryota, Sekine Ikuo, Iwasawa Shunichiro, Sakaida Emiko, Tada Yuji, Tatsumi Koichiro, Takahashi Yoko, Nakatani Yukio, Imai Chiaki, Takiguchi Yuichi: ペメトレキセド投与に関連した肺胞出血(Alveolar Hemorrhage Associated with Pemetrexed Administration) Internal Medicine. 2015.04; 54 (7): 833-836. ( 医中誌 )

  7. Koji Otabe, Hiroyuki Nakahara, Akihiko Hasegawa, Tetsuya Matsukawa, Fumiaki Ayabe, Naoko Onizuka, Masafumi Inui, Shuji Takada, Yoshiaki Ito, Ichiro Sekiya, Takeshi Muneta, Martin Lotz, Hiroshi Asahara: Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo. J. Orthop. Res.. 2015.01; 33 (1): 1-8. ( PubMed , DOI )

  8. Yohei Matsubara, Tomoko Kato, Kenichi Kashimada, Hiromitsu Tanaka, Zhou Zhi, Shizuko Ichinose, Shuki Mizutani, Tomohiro Morio, Tomoki Chiba, Yoshiaki Ito, Yumiko Saga, Shuji Takada, and Hiroshi Asahara: TALEN-Mediated Gene Disruption on Y Chromosome Reveals Critical Role of EIF2S3Y in Mouse Spermatogenesis Stem cells and development. 2015;

  9. Ishii T, Iwasawa S, Kurimoto R, Maeda A, Takiguchi Y, Kaneda M: Crizotinib-Induced Abnormal Signal Processing in the Retina. PloS one. 2015; 10 (8): e0135521. ( PubMed , DOI )

  10. Kurimoto R, Sekine I, Iwasawa S, Sakaida E, Tada Y, Tatsumi K, Takahashi Y, Nakatani Y, Imai C, Takiguchi Y: Alveolar hemorrhage associated with pemetrexed administration. Internal medicine (Tokyo, Japan). 2015; 54 (7): 833-6. ( PubMed , DOI )

  1. Chiba K, Araseki M, Nozawa K, Furukori K, Araki Y, Matsushima T, Nakaya T, Hata S, Saito Y, Uchida S, Okada Y, Nairn AC, Davis RJ, Yamamoto T, Kinjo M, Taru H, Suzuki T: Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport. Molecular biology of the cell. 2014.11; 25 (22): 3569-80. ( PubMed , DOI )

  2. Nagata Eiko, Kano Hiroki, Kato Fumiko, Yamaguchi Rie, Nakashima Shinichi, Takayama Shinichiro, Kosaki Rika, Tonoki Hidefumi, Mizuno Seiji, Watanabe Satoshi, Yoshiura Koh-Ichiro, Kosho Tomoki, Hasegawa Tomonobu, Kimizuka Mamori, Suzuki Atsushi, Shimizu Kenji, Ohashi Hirofumi, Haga Nobuhiko, Numabe Hironao, Horii Emiko, Nagai Toshiro, Yoshihashi Hiroshi, Nishimura Gen, Toda Tatsushi, Takada Shuji, Yokoyama Shigetoshi, Asahara Hiroshi, Sano Shinichiro, Fukami Maki, Ikegawa Shiro, Ogata Tsutomu: Japanese founder duplications/triplications involving BHLHA9 are associated with split-hand/foot malformation with or without long bone deficiency and Gollop-Wolfgang complex. Orphanet J Rare Dis. 2014.10; 9 (1): 125. ( PubMed , DOI )

  3. Miyata Kohei, Yotsumoto Fusanori, Nam Sung Ouk, Odawara Takashi, Manabe Sadao, Ishikawa Toyokazu, Itamochi Hiroaki, Kigawa Junzo, Takada Shuji, Asahara Hiroshi, Kuroki Masahide, Miyamoto Shingo: Contribution of transcription factor, SP1, to the promotion of HB-EGF expression in defense mechanism against the treatment of irinotecan in ovarian clear cell carcinoma. Cancer Med. 2014.10; 3 (5): 1159-1169. ( PubMed , DOI )

  4. Takiguchi Y, Sekine I, Iwasawa S, Kurimoto R, Tatsumi K: Chronic obstructive pulmonary disease as a risk factor for lung cancer. World journal of clinical oncology. 2014.10; 5 (4): 660-6. ( PubMed , DOI )

  5. Miyata Kohei, Miyata Tomoko, Nakabayashi Kazuhiko, Okamura Kohji, Naito Masashi, Kawai Tomoko, Takada Shuji, Kato Kiyoko, Miyamoto Shingo, Hata Kenichiro, Asahara Hiroshi: DNA methylation analysis of human myoblasts during in vitro myogenic differentiation: de novo methylation of promoters of muscle-related genes and its involvement in transcriptional down-regulation. Hum Mol Genet. 2014.09; 24 (2): 410-423. ( PubMed , DOI )

  6. Takiguchi Yuichi, Sekine Ikuo, Iwasawa Shunichiro, Kurimoto Ryota, Sakaida Emiko, Tamura Kenji: 日本における内科的腫瘍学の現状　がん診療連携拠点病院に送付した質問紙調査から明らかになった現実(Current Status of Medical Oncology in Japan: Reality Gleaned from a Questionnaire Sent to Designated Cancer Care Hospitals) Japanese Journal of Clinical Oncology. 2014.07; 44 (7): 632-640. ( 医中誌 )

  7. Takiguchi Y, Sekine I, Iwasawa S, Kurimoto R, Sakaida E, Tamura K: Current status of medical oncology in Japan--reality gleaned from a questionnaire sent to designated cancer care hospitals. Japanese journal of clinical oncology. 2014.07; 44 (7): 632-40. ( PubMed , DOI )

  8. Takiguchi Y, Sekine I, Iwasawa S, Kurimoto R, Uehara T: Stereotactic radiosurgery for patients with brain metastases. The Lancet. Oncology. 2014.06; 15 (7): e247-8. ( PubMed , DOI )

  9. Kei Takasawa, Kenichi Kashimada, Emanuele Pelosi, Masatoshi Takagi, Tomohiro Morio, Hiroshi Asahara, David Schlessinger, Shuki Mizutani, Peter Koopman: FOXL2 transcriptionally represses Sf1 expression by antagonizing WT1 during ovarian development in mice. FASEB J.. 2014.05; 28 (5): 2020-2028. ( PubMed , DOI )

  10. Shinohara Masahiro, Chang Betty Y, Buggy Joseph J, Nagai Yusuke, Kodama Tatsuhiko, Asahara Hiroshi, Takayanagi Hiroshi: The orally available Btk inhibitor ibrutinib (PCI-32765) protects against osteoclast-mediated bone loss. Bone. 2014.03; 60 8-15. ( PubMed , DOI )

  11. Sakaida Emiko, Sekine Ikuo, Iwasawa Shunichiro, Kurimoto Ryota, Uehara Takashi, Ooka Yoshihiko, Akanuma Naoki, Tada Yuji, Imai Chiaki, Oku Tomoko, Takiguchi Yuichi: 外来化学療法クリニックにおける細胞毒性薬の血管外漏出の発生率、危険因子、治療転帰(Incidence, Risk Factors and Treatment Outcomes of Extravasation of Cytotoxic Agents in an Outpatient Chemotherapy Clinic) Japanese Journal of Clinical Oncology. 2014.02; 44 (2): 168-171. ( 医中誌 )

  12. Sakaida E, Sekine I, Iwasawa S, Kurimoto R, Uehara T, Ooka Y, Akanuma N, Tada Y, Imai C, Oku T, Takiguchi Y: Incidence, risk factors and treatment outcomes of extravasation of cytotoxic agents in an outpatient chemotherapy clinic. Japanese journal of clinical oncology. 2014.02; 44 (2): 168-71. ( PubMed , DOI )

  13. Onizuka Naoko, Ito Yoshiaki, Inagawa Masayo, Nakahara Hiroyuki, Takada Shuji, Lotz Martin, Toyama Yoshiaki, Asahara Hiroshi: The Mohawk homeobox transcription factor regulates the differentiation of tendons and volar plates. J Orthop Sci. 2014.01; 19 (1): 172-180. ( PubMed , DOI )

  14. Akasaki Y, Hasegawa A, Saito M, Asahara H, Iwamoto Y, Lotz M K: Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis. Osteoarthritis Cartilage. 2014.01; 22 (1): 162-170. ( PubMed , DOI )

  15. Inui Masafumi, Miyado Mami, Igarashi Maki, Tamano Moe, Kubo Atsushi, Yamashita Satoshi, Asahara Hiroshi, Fukami Maki, Takada Shuji: Rapid generation of mouse models with defined point mutations by the CRISPR/Cas9 system. Sci Rep. 2014; 4 5396. ( PubMed , DOI )

  16. Yohei Matsubara, Tomoki Chiba, Kenichi Kashimada, Tomohiro Morio, Shuji Takada, Shuki Mizutani, Hiroshi Asahara: Transcription activator-like effector nuclease-mediated transduction of exogenous gene into IL2RG locus. Sci Rep. 2014; 4 5043. ( PubMed , DOI )

  1. Yoshitaka Teruhito, Kawai Akira, Miyaki Shigeru, Numoto Kunihiko, Kikuta Kazutaka, Ozaki Toshifumi, Lotz Martin, Asahara Hiroshi: Analysis of microRNAs expressions in chondrosarcoma. J Orthop Res. 2013.12; 31 (12): 1992-1998. ( PubMed , DOI )

  2. Kato Tomoko, Miyata Kohei, Sonobe Miku, Yamashita Satoshi, Tamano Moe, Miura Kento, Kanai Yoshiakira, Miyamoto Shingo, Sakuma Tetsushi, Yamamoto Takashi, Inui Masafumi, Kikusui Takefumi, Asahara Hiroshi, Takada Shuji: Production of Sry knockout mouse using TALEN via oocyte injection. Sci Rep. 2013.11; 3 3136. ( PubMed , DOI )

  3. Shimizu Hirohito, Kubo Atsushi, Uchibe Kenta, Hashimoto Megumi, Yokoyama Shigetoshi, Takada Shuji, Mitsuoka Kazuhiko, Asahara Hiroshi: The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013.10; 8 (10): e75754. ( PubMed , DOI )

  4. Takada Shuji, Sato Tempei, Ito Yoshiaki, Yamashita Satoshi, Kato Tomoko, Kawasumi Miyuri, Kanai-Azuma Masami, Igarashi Arisa, Kato Tomomi, Tamano Moe, Asahara Hiroshi: Targeted gene deletion of miRNAs in mice by TALEN system. PLoS One. 2013.10; 8 (10): e76004. ( PubMed , DOI )

  5. Gibson Gary, Asahara Hiroshi: microRNAs and cartilage. J Orthop Res. 2013.09; 31 (9): 1333-1344. ( PubMed , DOI )

  6. Nakahara Hiroyuki, Hasegawa Akihiko, Otabe Koji, Ayabe Fumiaki, Matsukawa Tetsuya, Onizuka Naoko, Ito Yoshiaki, Ozaki Toshifumi, Lotz Martin K, Asahara Hiroshi: Transcription factor Mohawk and the pathogenesis of human anterior cruciate ligament degradation. Arthritis Rheum. 2013.08; 65 (8): 2081-2089. ( PubMed , DOI )

  7. Rakoczy Joanna, Fernandez-Valverde Selene L, Glazov Evgeny A, Wainwright Elanor N, Sato Tempei, Takada Shuji, Combes Alexander N, Korbie Darren J, Miller David, Grimmond Sean M, Little Melissa H, Asahara Hiroshi, Mattick John S, Taft Ryan J, Wilhelm Dagmar: MicroRNAs-140-5p/140-3p modulate Leydig cell numbers in the developing mouse testis. Biol Reprod. 2013.06; 88 (6): 143. ( PubMed , DOI )

  8. Matsukawa Tetsuya, Sakai Tadahiro, Yonezawa Tomo, Hiraiwa Hideki, Hamada Takashi, Nakashima Motoshige, Ono Yohei, Ishizuka Shinya, Nakahara Hiroyuki, Lotz Martin K, Asahara Hiroshi, Ishiguro Naoki: MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes. Arthritis Res Ther. 2013.02; 15 (1): R28. ( PubMed , DOI )

  9. Hasegawa Akihiko, Nakahara Hiroyuki, Kinoshita Mitsuo, Asahara Hiroshi, Koziol James, Lotz Martin K: Cellular and extracellular matrix changes in anterior cruciate ligaments during human knee aging and osteoarthritis. Arthritis Res Ther. 2013.02; 15 (1): R29. ( PubMed , DOI )

  10. Takata Akemi, Otsuka Motoyuki, Yoshikawa Takeshi, Kishikawa Takahiro, Hikiba Yohko, Obi Shuntaro, Goto Tadashi, Kang Young Jun, Maeda Shin, Yoshida Haruhiko, Omata Masao, Asahara Hiroshi, Koike Kazuhiko: MicroRNA-140 acts as a liver tumor suppressor by controlling NF-kappaB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression. Hepatology. 2013.01; 57 (1): 162-170. ( PubMed , DOI )

  11. Watanabe Takashi, Oyama Toshinao, Asada Maki, Harada Daisuke, Ito Yoshiaki, Inagawa Masayo, Suzuki Yutaka, Sugano Sumio, Katsube Ken-ichi, Karsenty Gerard, Komori Toshihisa, Kitagawa Motoo, Asahara Hiroshi: MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development. PLoS Genet. 2013.01; 9 (1): e1003132. ( PubMed , DOI )

  12. Hoshino T, Suzuki K, Matsushima T, Yamakawa N, Suzuki T, Mizushima T: Suppression of Alzheimer's disease-related phenotypes by geranylgeranylacetone in mice. PloS one. 2013; 8 (10): e76306. ( PubMed , DOI )

  13. Furumatsu Takayuki, Asahara Hiroshi: Chromatin assembly and in vitro transcription analyses for evaluation of individual protein activities in multicomponent transcriptional complexes. Methods Mol Biol. 2013; 977 193-202. ( PubMed , DOI )

  14. Shimomura I, Tada Y, Miura G, Suzuki T, Matsumura T, Tsushima K, Terada J, Kurimoto R, Sakaida E, Sekine I, Takiguchi Y, Yamamoto S, Tatsumi K: Choroidal metastasis of non-small cell lung cancer that responded to gefitinib. Case reports in ophthalmological medicine. 2013; 2013 213124. ( PubMed , DOI )

  1. Miyaki Shigeru, Asahara Hiroshi: Macro view of microRNA function in osteoarthritis. Nat Rev Rheumatol. 2012.09; 8 (9): 543-552. ( PubMed , DOI )

  2. Ito Yoshiaki, Kayama Tomohiro, Asahara Hiroshi: A systems approach and skeletal myogenesis. Comp Funct Genomics. 2012.09; 2012 759407. ( PubMed , DOI )

  3. Shuji Takada, Hiroshi Asahara: Current strategies for microRNA research. Mod Rheumatol. 2012.09; 22 (5): 645-653. ( PubMed , DOI )

  4. Uchibe Kenta, Shimizu Hirohito, Yokoyama Shigetoshi, Kuboki Takuo, Asahara Hiroshi: Identification of novel transcription-regulating genes expressed during murine molar development. Dev Dyn. 2012.07; 241 (7): 1217-1226. ( PubMed , DOI )

  5. Fukami Maki, Tsuchiya Takayoshi, Takada Shuji, Kanbara Akiko, Asahara Hiroshi, Igarashi Arisa, Kamiyama Yasunori, Nishimura Gen, Ogata Tsutomu: Complex genomic rearrangement in the SOX9 5' region in a patient with Pierre Robin sequence and hypoplastic left scapula. Am J Med Genet A. 2012.07; 158A (7): 1529-1534. ( PubMed , DOI )

  6. Matsushima T, Saito Y, Elliott JI, Iijima-Ando K, Nishimura M, Kimura N, Hata S, Yamamoto T, Nakaya T, Suzuki T: Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue. The Journal of biological chemistry. 2012.06; 287 (23): 19715-24. ( PubMed , DOI )

  7. Yamashita Satoshi, Miyaki Shigeru, Kato Yoshio, Yokoyama Shigetoshi, Sato Tempei, Barrionuevo Francisco, Akiyama Haruhiko, Scherer Gerd, Takada Shuji, Asahara Hiroshi: L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity. J Biol Chem. 2012.06; 287 (26): 22206-22215. ( PubMed , DOI )

  8. Elaine F Chan, Ricky Harjanto, Hiroshi Asahara, Nozomu Inoue, Koichi Masuda, William D Bugbee, Gary S Firestein, Harish S Hosalkar, Martin K Lotz, Robert L Sah: Structural and functional maturation of distal femoral cartilage and bone during postnatal development and growth in humans and mice. Orthop. Clin. North Am.. 2012.04; 43 (2): 173-85, v. ( PubMed , DOI )

  9. Hoshino T, Namba T, Takehara M, Murao N, Matsushima T, Sugimoto Y, Narumiya S, Suzuki T, Mizushima T: Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP(4) receptor. Journal of neurochemistry. 2012.03; 120 (5): 795-805. ( PubMed , DOI )

  10. Satoshi Yamashita and Hiroshi Asahara: miRNA Functions in Arthritis Current Rheumatology Reviews. 2012; 8 98-102.

  1. Shogo Wada, Yoshio Kato, Mitsuharu Okutsu, Shigeru Miyaki, Katsuhiko Suzuki, Zhen Yan, Stefano Schiaffino, Hiroshi Asahara, Takashi Ushida, Takayuki Akimoto: Translational suppression of atrophic regulators by microRNA-23a integrates resistance to skeletal muscle atrophy. J. Biol. Chem.. 2011.11; 286 (44): 38456-38465. ( PubMed , DOI )

  2. Hiroshi Asahara: Switching gears to an arthritis gene expression network by SirT1 cleavage. Arthritis Rheum.. 2011.08; 63 (8): 2161-2163. ( PubMed , DOI )

  3. Shigetoshi Yokoyama, Hiroshi Asahara: The myogenic transcriptional network. Cell. Mol. Life Sci.. 2011.06; 68 (11): 1843-1849. ( PubMed , DOI )

  4. Motoharu Awazawa, Kohjiro Ueki, Kazunori Inabe, Toshimasa Yamauchi, Naoto Kubota, Kazuma Kaneko, Masatoshi Kobayashi, Aya Iwane, Takayoshi Sasako, Yukiko Okazaki, Mitsuru Ohsugi, Iseki Takamoto, Satoshi Yamashita, Hiroshi Asahara, Shizuo Akira, Masato Kasuga, Takashi Kadowaki: Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway. Cell Metab.. 2011.04; 13 (4): 401-412. ( PubMed , DOI )

  5. Hoshino T, Murao N, Namba T, Takehara M, Adachi H, Katsuno M, Sobue G, Matsushima T, Suzuki T, Mizushima T: Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011.04; 31 (14): 5225-34. ( PubMed , DOI )

  6. Maki Asada, Alexander Rauch, Hirohito Shimizu, Hiromi Maruyama, Shigeru Miyaki, Masafumi Shibamori, Hideki Kawasome, Hironobu Ishiyama, Jan Tuckermann, Hiroshi Asahara: DNA binding-dependent glucocorticoid receptor activity promotes adipogenesis via Krüppel-like factor 15 gene expression. Lab. Invest.. 2011.02; 91 (2): 203-215. ( PubMed , DOI )

  7. Reiko Mizutani, Kazuaki Nakamura, Shigetoshi Yokoyama, Atsushi Sanbe, Shinji Kusakawa, Yuki Miyamoto, Tomohiro Torii, Hiroshi Asahara, Haruo Okado, Junji Yamauchi, Akito Tanoue: Developmental expression of sorting nexin 3 in the mouse central nervous system. Gene Expr. Patterns. 2011.01; 11 (1-2): 33-40. ( PubMed , DOI )

  1. Takayuki Furumatsu, Hiroshi Asahara: Histone acetylation influences the activity of Sox9-related transcriptional complex. Acta Med. Okayama. 2010.12; 64 (6): 351-357. ( PubMed , DOI )

  2. Kondo M, Shiono M, Itoh G, Takei N, Matsushima T, Maeda M, Taru H, Hata S, Yamamoto T, Saito Y, Suzuki T: Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain. Molecular neurodegeneration. 2010.09; 5 35. ( PubMed , DOI )

  3. Ito Y, Toriuchi N, Yoshitaka T, Ueno-Kudoh H, Sato T, Yokoyama S, Nishida K, Akimoto T, Takahashi M, Miyaki S, Asahara H: The Mohawk homeobox gene is a critical regulator of tendon differentiation. Proc Natl Acad Sci USA. 2010.06; 107 (23): 10538-10542. ( PubMed , DOI )

  4. Miyaki S, Sato T, Inoue A, Otsuki S, Ito Y, Yokoyama S, Kato Y, Takemoto F, Nakasa T, Yamashita S, Takada S, Lotz MK, Ueno-Kudo H, Asahara H: MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev. 2010.06; 24 (11): 1173-1185. ( PubMed , DOI )

  5. Shuhei Otsuki, Sarah R Hanson, Shigeru Miyaki, Shawn P Grogan, Mitsuo Kinoshita, Hiroshi Asahara, Chi-Huey Wong, Martin K Lotz: Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways. Proc. Natl. Acad. Sci. U.S.A.. 2010.06; 107 (22): 10202-10207. ( PubMed , DOI )

  6. Nakanishi K, Nakasa T, Tanaka N, Ishikawa M, Yamada K, Yamasaki K, Kamei N, Izumi B, Adachi N, Miyaki S, Asahara H, Ochi M. : Responses of microRNAs 124a and 223 following spinal cord injury in mice. Spinal Cord. 2010.03; 48 (3): 192-196. ( PubMed , DOI )

  7. Reiji Higashiyama, Shigeru Miyaki, Satoshi Yamashita, Teruhito Yoshitaka, Görel Lindman, Yoshiaki Ito, Takahisa Sasho, Kazuhisa Takahashi, Martin Lotz, Hiroshi Asahara: Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis. Mod Rheumatol. 2010.02; 20 (1): 11-17. ( PubMed , DOI )

  8. Shuhei Otsuki, Shawn P Grogan, Shigeru Miyaki, Mitsuo Kinoshita, Hiroshi Asahara, Martin K Lotz: Tissue neogenesis and STRO-1 expression in immature and mature articular cartilage. J. Orthop. Res.. 2010.01; 28 (1): 96-102. ( PubMed , DOI )

  1. Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009.12; 17 (6): 836-848. ( PubMed , DOI )

  2. Kato Y, Miyaki S, Yokoyama S, Omori S, Inoue A, Horiuchi M, Asahara H: Real-time functional imaging for monitoring miR-133 during myogenic differentiation. The international journal of biochemistry & cell biology. 2009.11; 41 (11): 2225-31. ( PubMed , DOI )

  3. Abe Y, Oka A, Mizuguchi M, Igarashi T, Ishikawa S, Aburatani H, Yokoyama S, Asahara H, Nagao K, Yamada M, Miyashita T: EYA4, deleted in a case with middle interhemispheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally. Human mutation. 2009.10; 30 (10): E946-55. ( PubMed , DOI )

  4. Miyaki S, Nakasa T, Otsuki S, Grogan SP, Higashiyama R, Inoue A, Kato Y, Sato T, Lotz MK, Asahara H: MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses. Arthritis and rheumatism. 2009.09; 60 (9): 2723-30. ( PubMed , DOI )

  5. Nagata Y, Nakasa T, Mochizuki Y, Ishikawa M, Miyaki S, Shibuya H, Yamasaki K, Adachi N, Asahara H, Ochi M: Induction of apoptosis in the synovium of mice with autoantibody-mediated arthritis by the intraarticular injection of double-stranded MicroRNA-15a. Arthritis and rheumatism. 2009.09; 60 (9): 2677-83. ( PubMed , DOI )

  6. Ito T, Yadav N, Lee J, Furumatsu T, Yamashita S, Yoshida K, Taniguchi N, Hashimoto M, Tsuchiya M, Ozaki T, Lotz M, Bedford MT, Asahara H: Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification. BMC developmental biology. 2009.09; 9 47. ( PubMed , DOI )

  7. Yamashita S, Andoh M, Ueno-Kudoh H, Sato T, Miyaki S, Asahara H: Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes. Experimental cell research. 2009.08; 315 (13): 2231-40. ( PubMed , DOI )

  8. Grogan SP, Miyaki S, Asahara H, D'Lima DD, Lotz MK: Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis. Arthritis research & therapy. 2009.06; 11 (3): R85. ( PubMed , DOI )

  9. Furumatsu T, Ozaki T, Asahara H: Smad3 activates the Sox9-dependent transcription on chromatin. The international journal of biochemistry & cell biology. 2009.05; 41 (5): 1198-204. ( PubMed , DOI )

  10. FANTOM Consortium., Suzuki H, Forrest AR, van Nimwegen E, Daub CO, Balwierz PJ, Irvine KM, Lassmann T, Ravasi T, Hasegawa Y, de Hoon MJ, Katayama S, Schroder K, Carninci P, Tomaru Y, Kanamori-Katayama M, Kubosaki A, Akalin A, Ando Y, Arner E, Asada M, Asahara H, Bailey T, Bajic VB, Bauer D, Beckhouse AG, Bertin N, Björkegren J, Brombacher F, Bulger E, Chalk AM, Chiba J, Cloonan N, Dawe A, Dostie J, Engström PG, Essack M, Faulkner GJ, Fink JL, Fredman D, Fujimori K, Furuno M, Gojobori T, Gough J, Grimmond SM, Gustafsson M, Hashimoto M, Hashimoto T, Hatakeyama M, Heinzel S, Hide W, Hofmann O, Hörnquist M, Huminiecki L, Ikeo K, Imamoto N, Inoue S, Inoue Y, Ishihara R, Iwayanagi T, Jacobsen A, Kaur M, Kawaji H, Kerr MC, Kimura R, Kimura S, Kimura Y, Kitano H, Koga H, Kojima T, Kondo S, Konno T, Krogh A, Kruger A, Kumar A, Lenhard B, Lennartsson A, Lindow M, Lizio M, Macpherson C, Maeda N, Maher CA, Maqungo M, Mar J, Matigian NA, Matsuda H, Mattick JS, Meier S, Miyamoto S, Miyamoto-Sato E, Nakabayashi K, Nakachi Y, Nakano M, Nygaard S, Okayama T, Okazaki Y, Okuda-Yabukami H, Orlando V, Otomo J, Pachkov M, Petrovsky N, Plessy C, Quackenbush J, Radovanovic A, Rehli M, Saito R, Sandelin A, Schmeier S, Schönbach C, Schwartz AS, Semple CA, Sera M, Severin J, Shirahige K, Simons C, St Laurent G, Suzuki M, Suzuki T, Sweet MJ, Taft RJ, Takeda S, Takenaka Y, Tan K, Taylor MS, Teasdale RD, Tegnér J, Teichmann S, Valen E, Wahlestedt C, Waki K, Waterhouse A, Wells CA, Winther O, Wu L, Yamaguchi K, Yanagawa H, Yasuda J, Zavolan M, Hume DA, Riken Omics Science Center., Arakawa T, Fukuda S, Imamura K, Kai C, Kaiho A, Kawashima T, Kawazu C, Kitazume Y, Kojima M, Miura H, Murakami K, Murata M, Ninomiya N, Nishiyori H, Noma S, Ogawa C, Sano T, Simon C, Tagami M, Takahashi Y, Kawai J, Hayashizaki Y: The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nature genetics. 2009.05; 41 (5): 553-62. ( PubMed , DOI )

  11. Yamasaki K, Nakasa T, Miyaki S, Ishikawa M, Deie M, Adachi N, Yasunaga Y, Asahara H, Ochi M: Expression of MicroRNA-146a in osteoarthritis cartilage. Arthritis and rheumatism. 2009.04; 60 (4): 1035-41. ( PubMed , DOI )

  12. Hikata T, Takaishi H, Takito J, Hakozaki A, Furukawa M, Uchikawa S, Kimura T, Okada Y, Matsumoto M, Yoshimura A, Nishimura R, Reddy SV, Asahara H, Toyama Y: PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts. Blood. 2009.03; 113 (10): 2202-12. ( PubMed , DOI )

  13. Shimizu H, Uchibe K, Asahara H: Large-scale whole mount in situ hybridization of mouse embryos. Methods in molecular biology (Clifton, N.J.). 2009; 577 167-79. ( PubMed , DOI )

  14. Kumagishi K, Nishida K, Yamaai T, Momota R, Miyaki S, Hirohata S, Naito I, Asahara H, Ninomiya Y, Ohtsuka A: A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) expression by chondrocytes during endochondral ossification. Archives of histology and cytology. 2009; 72 (3): 175-85. ( PubMed )

  1. Sakai N, Terami H, Suzuki S, Haga M, Nomoto K, Tsuchida N, Morohashi K, Saito N, Asada M, Hashimoto M, Harada D, Asahara H, Ishikawa T, Shimada F, Sakurada K: Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies. The Journal of endocrinology. 2008.09; 198 (3): 489-97. ( PubMed , DOI )

  2. Hashimoto M, Nakasa T, Hikata T, Asahara H: Molecular network of cartilage homeostasis and osteoarthritis. Medicinal research reviews. 2008.05; 28 (3): 464-81. ( PubMed , DOI )

  3. Nakasa T, Miyaki S, Okubo A, Hashimoto M, Nishida K, Ochi M, Asahara H: Expression of microRNA-146 in rheumatoid arthritis synovial tissue. Arthritis and rheumatism. 2008.05; 58 (5): 1284-92. ( PubMed , DOI )

  4. Yokoyama S, Hashimoto M, Shimizu H, Ueno-Kudoh H, Uchibe K, Kimura I, Asahara H: Dynamic gene expression of Lin-28 during embryonic development in mouse and chicken. Gene expression patterns : GEP. 2008.02; 8 (3): 155-60. ( PubMed , DOI )

  5. H Manabe, Y Nasu, T Komiyama, T Furumatsu, A Kitamura, S Miyazawa, Y Ninomiya, T Ozaki, H Asahara, K Nishida: Inhibition of histone deacetylase down-regulates the expression of hypoxia-induced vascular endothelial growth factor by rheumatoid synovial fibroblasts. Inflamm Res. 2008.01; 57 (1): 4-10. ( PubMed , DOI )

  6. Teruhito Yoshitaka, Hiroshi Asahara,: Epigenetics and Cartilage Regulation US Musculoskeletal Review. 2008; 3 (1): 45-47.

  1. Taniguchi N, Yoshida K, Ito T, Tsuda M, Mishima Y, Furumatsu T, Ronfani L, Abeyama K, Kawahara K, Komiya S, Maruyama I, Lotz M, Bianchi ME, Asahara H: Stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification. Molecular and cellular biology. 2007.08; 27 (16): 5650-63. ( PubMed , DOI )

  2. Shimizu H, Yokoyama S, Asahara H: Growth and differentiation of the developing limb bud from the perspective of chondrogenesis. Development, growth & differentiation. 2007.08; 49 (6): 449-54. ( PubMed , DOI )

  1. Kojiro Sato, Ayako Suematsu, Tomoki Nakashima, Sayaka Takemoto-Kimura, Kazuhiro Aoki, Yasuyuki Morishita, Hiroshi Asahara, Keiichi Ohya, Akira Yamaguchi, Toshiyuki Takai, Tatsuhiko Kodama, Talal A Chatila, Haruhiko Bito, Hiroshi Takayanagi: Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat. Med.. 2006.12; 12 (12): 1410-1416. ( PubMed , DOI )

  1. Furumatsu T, Tsuda M, Yoshida K, Taniguchi N, Ito T, Hashimoto M, Ito T, Asahara H: Sox9 and p300 cooperatively regulate chromatin-mediated transcription. The Journal of biological chemistry. 2005.10; 280 (42): 35203-8. ( PubMed , DOI )

  2. Furumatsu T, Tsuda M, Taniguchi N, Tajima Y, Asahara H: Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding protein/p300 recruitment. The Journal of biological chemistry. 2005.03; 280 (9): 8343-50. ( PubMed , DOI )

  3. Kawakami Y, Tsuda M, Takahashi S, Taniguchi N, Esteban CR, Zemmyo M, Furumatsu T, Lotz M, Izpisúa Belmonte JC, Asahara H: Transcriptional coactivator PGC-1alpha regulates chondrogenesis via association with Sox9. Proceedings of the National Academy of Sciences of the United States of America. 2005.02; 102 (7): 2414-9. ( PubMed , DOI )

  1. Kato T, Asahara H, Kurokawa MS, Fujisawa K, Hasunuma T, Inoue H, Tsuda M, Takahashi S, Motokawa S, Sumida T, Nishioka K: HTLV-I env protein acts as a major antigen in patients with HTLV-I-associated arthropathy. Clinical rheumatology. 2004.10; 23 (5): 400-9. ( PubMed , DOI )

  2. Nishida K, Komiyama T, Miyazawa S, Shen ZN, Furumatsu T, Doi H, Yoshida A, Yamana J, Yamamura M, Ninomiya Y, Inoue H, Asahara H: Histone deacetylase inhibitor suppression of autoantibody-mediated arthritis in mice via regulation of p16INK4a and p21(WAF1/Cip1) expression. Arthritis and rheumatism. 2004.10; 50 (10): 3365-76. ( PubMed , DOI )

  3. Omoto S, Nishida K, Yamaai Y, Shibahara M, Nishida T, Doi T, Asahara H, Nakanishi T, Inoue H, Takigawa M: Expression and localization of connective tissue growth factor (CTGF/Hcs24/CCN2) in osteoarthritic cartilage. Osteoarthritis and cartilage. 2004.10; 12 (10): 771-8. ( PubMed , DOI )

  1. Kawakami Y, Rodríguez-León J, Koth CM, Büscher D, Itoh T, Raya A, Ng JK, Esteban CR, Takahashi S, Henrique D, Schwarz MF, Asahara H, Izpisúa Belmonte JC: MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb. Nature cell biology. 2003.06; 5 (6): 513-9. ( PubMed , DOI )

  2. Canettieri G, Morantte I, Guzmán E, Asahara H, Herzig S, Anderson SD, Yates JR 3rd, Montminy M: Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex. Nature structural biology. 2003.03; 10 (3): 175-81. ( PubMed , DOI )

  1. Asahara H, Tartare-Deckert S, Nakagawa T, Ikehara T, Hirose F, Hunter T, Ito T, Montminy M: Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. Molecular and cellular biology. 2002.05; 22 (9): 2974-83. ( PubMed )

  1. W Xu, H Chen, K Du, H Asahara, M Tini, B M Emerson, M Montminy, R M Evans: A transcriptional switch mediated by cofactor methylation. Science. 2001.12; 294 (5551): 2507-2511. ( PubMed , DOI )

  2. H Asahara, B Santoso, E Guzman, K Du, P A Cole, I Davidson, M Montminy: Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB. Mol. Cell. Biol.. 2001.12; 21 (23): 7892-7900. ( PubMed , DOI )

  3. F Long, E Schipani, H Asahara, H Kronenberg, M Montminy: The CREB family of activators is required for endochondral bone development. Development. 2001.02; 128 (4): 541-550. ( PubMed )

  4. T Sekine, K Masuko-Hongo, T Matsui, H Asahara, M Takigawa, K Nishioka, T Kato: Recognition of YKL-39, a human cartilage related protein, as a target antigen in patients with rheumatoid arthritis. Ann. Rheum. Dis.. 2001.01; 60 (1): 49-54. ( PubMed )

  1. K Du, H Asahara, U S Jhala, B L Wagner, M Montminy: Characterization of a CREB gain-of-function mutant with constitutive transcriptional activity in vivo. Mol. Cell. Biol.. 2000.06; 20 (12): 4320-4327. ( PubMed )

  2. K Asaumi, T Nakanishi, H Asahara, H Inoue, M Takigawa: Expression of neurotrophins and their receptors (TRK) during fracture healing. Bone. 2000.06; 26 (6): 625-633. ( PubMed )

  3. M Shibahara, K Nishida, H Asahara, T Yoshikawa, S Mitani, Y Kondo, H Inoue: Increased osteocyte apoptosis during the development of femoral head osteonecrosis in spontaneously hypertensive rats. Acta Med. Okayama. 2000.04; 54 (2): 67-74. ( PubMed , DOI )

  4. L F Michael, H Asahara, A I Shulman, W L Kraus, M Montminy: The phosphorylation status of a cyclic AMP-responsive activator is modulated via a chromatin-dependent mechanism. Mol. Cell. Biol.. 2000.03; 20 (5): 1596-1603. ( PubMed )

  1. H Asahara, S Dutta, H Y Kao, R M Evans, M Montminy: Pbx-Hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner. Mol. Cell. Biol.. 1999.12; 19 (12): 8219-8225. ( PubMed )

  2. M Suzuki, H Asahara, S Endo, K Inada, M Doi, K Kuroda, A Ogawa: Increased levels of nitrite/nitrate in the cerebrospinal fluid of patients with subarachnoid hemorrhage. Neurosurg Rev. 1999.10; 22 (2-3): 96-98. ( PubMed )

  3. T Maeda, H Keino, H Asahara, M Taniguchi, K Nishioka, T Sumida: Decreased TCR AV24AJ18+ double-negative T cells in rheumatoid synovium. Rheumatology (Oxford). 1999.02; 38 (2): 186-188. ( PubMed )

  1. K Okamoto, H Asahara, T Kobayashi, H Matsuno, T Hasunuma, T Kobata, T Sumida, K Nishioka: Induction of apoptosis in the rheumatoid synovium by Fas ligand gene transfer. Gene Ther.. 1998.03; 5 (3): 331-338. ( PubMed , DOI )

  2. H Takagoshi, H Hashizume, K Nishida, S Masaoka, H Asahara, H Inoue: Fibrous structure and connection surrounding the metacarpophalangeal joint. Acta Med. Okayama. 1998.02; 52 (1): 19-26. ( PubMed , DOI )

  3. J Pu, K Nishida, H Inoue, H Asahara, A Ohtsuka, T Murakami: Mast cells in osteoarthritic and rheumatoid arthritic synovial tissues of the human knee. Acta Med. Okayama. 1998.02; 52 (1): 35-39. ( PubMed , DOI )

  4. T Sumida, T Hasunuma, H Asahara, T Maeda, K Nishioka: Rheumatoid arthritis and apoptosis. Intern. Med.. 1998.02; 37 (2): 184-188. ( PubMed )

  5. K Fujisawa, K Okamoto, H Asahara, T Hasunuma, T Kobata, T Kato, T Sumida, K Nishioka: Evidence for autoantigens of Env/Tax proteins in human T cell leukemia virus type I Env-pX transgenic mice. Arthritis Rheum.. 1998.01; 41 (1): 101-109. ( PubMed , DOI )

  1. T Kobata, K Takasaki, H Asahara, N M Hong, K Masuko-Hongo, T Kato, S Hirose, T Shirai, N Kayagaki, H Yagita, K Okumura, K Nishioka: Apoptosis with FasL+ cell infiltration in the periphery and thymus of corrected autoimmune mice. Immunology. 1997.10; 92 (2): 206-213. ( PubMed )

  2. C Xue, T Hasunuma, H Asahara, W Yin, T Maeda, K Fujisawa, Y Dong, T Sumida, K Nishioka: Transcriptional regulation of the HOX4C gene by basic fibroblast growth factor on rheumatoid synovial fibroblasts. Arthritis Rheum.. 1997.09; 40 (9): 1628-1635. ( PubMed , DOI )

  3. H Asahara, K Fujisawa, T Kobata, T Hasunuma, T Maeda, M Asanuma, N Ogawa, H Inoue, T Sumida, K Nishioka: Direct evidence of high DNA binding activity of transcription factor AP-1 in rheumatoid arthritis synovium. Arthritis Rheum.. 1997.05; 40 (5): 912-918. ( PubMed , DOI )

  4. M Suzuki, A Ogawa, H Asahara, S Endo, K Inada: Nitric oxide and vasospasm. J. Neurosurg.. 1997.04; 86 (4): 741-742. ( PubMed )

  5. H Asahara, T Hasunuma, T Kobata, H Inoue, U Muller-Ladner, S Gay, T Sumida, K Nishioka: In situ expression of protooncogenes and Fas/Fas ligand in rheumatoid arthritis synovium. J. Rheumatol.. 1997.03; 24 (3): 430-435. ( PubMed )

  6. T Sumida, T T Hoa, H Asahara, T Hasunuma, K Nishioka: T cell receptor of Fas-sensitive T cells in rheumatoid synovium. J. Immunol.. 1997.02; 158 (4): 1965-1970. ( PubMed )

  7. T Hasunuma, N Kayagaki, H Asahara, S Motokawa, T Kobata, H Yagita, H Aono, T Sumida, K Okumura, K Nishioka: Accumulation of soluble Fas in inflamed joints of patients with rheumatoid arthritis. Arthritis Rheum.. 1997.01; 40 (1): 80-86. ( PubMed )

  8. Habu H, Yokoi I, Kabuto H, Asahara H, Toma J, Inada K, Mori A.: The role of nitric oxide on α-guanidinoglutaric acid induced epileptic discharges. Guanidino Compounds: 2,. 1997; 373-377.

  9. Yokoi I, Kabuto H, Habu H, Inada K, Toma J, Asahara H, Mori A.: Structure-activity relationships of guanidine compounds on brain nitric oxide synthase activity. Guanidino Compounds: 2,. 1997; 3-7.

  1. T Hasunuma, T T Hoa, H Aono, H Asahara, S Yonehara, K Yamamoto, T Sumida, S Gay, K Nishioka: Induction of Fas-dependent apoptosis in synovial infiltrating cells in rheumatoid arthritis. Int. Immunol.. 1996.10; 8 (10): 1595-1602. ( PubMed )

  2. H Asahara, T Hasumuna, T Kobata, H Yagita, K Okumura, H Inoue, S Gay, T Sumida, K Nishioka: Expression of Fas antigen and Fas ligand in the rheumatoid synovial tissue. Clin. Immunol. Immunopathol.. 1996.10; 81 (1): 27-34. ( PubMed )

  3. K Fujisawa, H Asahara, K Okamoto, H Aono, T Hasunuma, T Kobata, Y Iwakura, S Yonehara, T Sumida, K Nishioka: Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice. J. Clin. Invest.. 1996.07; 98 (2): 271-278. ( PubMed , DOI )

  4. H Asahara, T Hasunuma, T Obata, T Sumida, K Nishioka: [Expression of Fas/Fas ligand and proto-oncogenes in rheumatoid synovial tissues]. Nihon Rinsho. 1996.07; 54 (7): 1960-1964. ( PubMed )

  5. H Asahara, A Kawai, Y Harada, M Senda, H Inoue: Spinal schwannomas: a review of 42 cases. Acta Med. Okayama. 1996.02; 50 (1): 25-28. ( PubMed , DOI )

  6. H Hashizume, H Asahara, K Nishida, H Inoue, T Konishiike: Histopathology of Kienböck's disease. Correlation with magnetic resonance and other imaging techniques. J Hand Surg Br. 1996.02; 21 (1): 89-93. ( PubMed )

  7. H Asahara, I Yokoi, T Tamada, H Kabuto, N Ogawab, A Mori, H Inoue: Increased cerebrospinal fluid nitrite and nitrate levels in patients with lumbar spondylosis. Res. Commun. Mol. Pathol. Pharmacol.. 1996.01; 91 (1): 77-83. ( PubMed )

  1. H Asahara, M Asanuma, N Ogawa, S Nishibayashi, H Inoue: High DNA-binding activity of transcription factor NF-kappa B in synovial membranes of patients with rheumatoid arthritis. Biochem. Mol. Biol. Int.. 1995.11; 37 (5): 827-832. ( PubMed )

  2. H Asahara, H Kabuto, I Yokoi, H Habu, A Mori, H Inoue: Nitric oxide synthase inhibited by audouine in the rat brain. Neuroreport. 1995.05; 6 (8): 1146-1148. ( PubMed )

  3. H Kabuto, I Yokoi, H Habu, H Asahara, A Mori: Inhibitory effect of arcaine on nitric oxide synthase in the rat brain. Neuroreport. 1995.02; 6 (3): 554-556. ( PubMed )

  1. Uchida Yutaro, Matsushima Takahide, Kurimoto Ryota, Chiba Tomoki, Inutani Yuki, Asahara Hiroshi: HiBiT tagging system for high throughput chemical screening for chemotherapy. CANCER RESEARCH. 2021.07; 81 (13):

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  1. 松島 隆英, 淺原 弘嗣: ゲノム編集のヒトへの応用の展望と問題点 リウマチ科. 2019.02; 61 (2): 191-196. ( 医中誌 )

  1. 栗本 遼太, 滝口 裕一: 【肺癌】 これからの実地医家のための診断とストラテジー　合併症のコントロール　制吐剤をいかに使うか Medical Practice. 2016.02; 33 (2): 231-234. ( 医中誌 )

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  2. Suzuki H, Asahara H: [Analysis of Musculoskeletal Systems and Their Diseases. The research for musculoskeletal disease using genome editing technology] Clin Calcium. 2015.08; 1169-1174. ( PubMed , DOI )

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  1. 栗本 遼太, 関根 郁夫: 【最新肺癌学-基礎と臨床の最新研究動向-】 肺癌の治療戦略　集学的治療　非小細胞肺癌における術前化学放射線療法について 日本臨床. 2013.11; 71 (増刊6 最新肺癌学): 599-603. ( 医中誌 )

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