The policy of the Department of Nephrology is to accomplish trustworthy medicine and to educate excellent academic scientists and nephrologists. Our department is one of the pioneering institutes that introduced the hemodialysis therapy in Japan, and thus, has a long experience of clinical practice of kidney diseases.
We are now investigating pathophysiological mechanisms of various kidney diseases including genetic renal diseases. Furthermore, we are taking a proactive stance in developing innovative therapy. We hope new young scientists and physicians join us for future science and nephrology.
The theme of our study is "to investigate the mechanisms of maintaining blood pressure and body fluids homeostasis regulated by the kidney and to clear the pathophysiology caused by their failure, and to develop novel strategies for their treatment.” This would lead to the development of kidney disease therapy itself and would also lead to studying for multiple organ failure caused by chronic kidney disease (CKD).
In 2018, our 13 presentations were adopted in the annual meeting of American Society of Nephrology (ASN KIDNEY WEEK). Moreover, our research manuscripts were published in several high impact journals such as Nature Communications (IF: 12.4), Kidney International (IF: 8.4), or Scientific Reports (IF: 4.3). We published 29 reports in English and six of them were presented in "press release".
In addition to them, a lot of our members have got prizes in various medical meetings regardless of whether they are in or out of the country. Further, comprehensive diagnosis of inherited kidney diseases using next generation sequencer (NGS) and clinical studies on genome information are now on track and is contributing to various genetic diagnosis of many patients. Genetic diagnosis was carried out for more than 200 cases a year. CKD-ROUTE study, which is the clinical cohort study with 1,000 subjects we take the initiative have been finished the observation period of 3 years, which enabled us to publish 9 clinical research papers (5 in Clin Exp Nephrol., 1 in Nephrology and others).
For third grade medical students, we are conducting lectures organized in a three-week ‘block form’ together with urology and pathology sections. Under the name of "Body Fluid Regulation and Urology" Block, the students can learn intensively about kidney and urologic diseases during a period of three weeks. In this lecture, we incorporate PBL (Problem-Based Learning) lectures and lectures held by actual patients, so that the students will be able to study independently and bi-directionally.
We accept several students every year in the project semester, in which they are expected to participate in the forefront research with the assistance of graduate students.
For the last three months of fourth grade following the systematic lectures and project semester, we provide the Pre-Clinical Clerkship (PCC) lectures for ten weeks (two weeks of large-class comprehensive lectures and eight weeks of small-class lectures), which are more practical and interactive than the previous lectures held in the classroom. After PCC, fifth grade students will undergo Clinical Clerkship (CC), in which they will actually take charge of patients in the hospital ward, and study about kidney diseases while developing their clinical skills. They will be in charge of one new inpatient each week, make a presentation about their patient at the regular ward conference, and are expected to learn about the pathophysiology of various kidney diseases in depth.
After the two-year initial training after graduation, postgraduate doctors will be engaged in clinical training as nephrologists either in the University Hospital or affiliated hospitals as senior trainees. During this period, we teach them so that they can be aware about unsolved clinical problems. We are planning to bring them up as “academic doctors”. Research activities in the graduate school are very active, and by carrying out the state-of-the-art research as described above, we are training doctors to be able to excel in both basic and clinical works.
Clinical Services & Other Works
We are one of the first groups that introduced the hemodialysis therapy in Japan, and thus, have a long experience of clinical practice of kidney diseases. We have close coordination with our 19 affiliated hospitals, and are performing CKD-ROUTE clinical cohort study stated above in cooperation with 15 hospitals of the 19, which enabled us to publish 7 clinical research papers. We continue to make an effort to reveal the pathophysiology of CKD patients. We have been actively adopting the “educational admission” for CKD patients and it has been showing the significant inhibitory effect on progression of kidney disease. For end-stage renal disease patients, vascular access surgery, peritoneal dialysis-related surgery, and induction of dialysis are consistently carried out in our department. Our hemopurification center is one of the biggest institutions among 42 hospitals belonging to national universities. In 2018, the number of newly started dialysis patients and plasma exchange were in 1st place, the total number of blood purifications and the number of hemodialysis were in 2nd place. Furthermore, we developed diagnostic panel for comprehensive genetic diagnosis for hereditary kidney diseases like nephrogenic diabetes insipidus, peudohypoaldosteronism type II, Liddle syndrome, and Polycystic kidney diseases. Currently, we receive requests of genetic tests from all over the country. Genetic screening using next-generation sequencing technology enables definite diagnosis for rare hereditary diseases.