1. Toru Kanno, Kazuo Otsuka, Ryoichi Saito, Katsuhiro Ito, Shigeki Koterazawa, Shinya Somiya, Takao Haitani, Yoshihito Higashi, Hitoshi Yamada: Minimally invasive total pelvic exenteration for symptomatic locally advanced prostate cancer with rectal invasion: Indications and technical considerations. Asian J Endosc Surg. 2024.04; 17 (2): e13290. ( PubMed , DOI )

  2. Motoki Makuuchi, Yoichi Kakuta, Junji Umeno, Toshimitsu Fujii, Tetsuya Takagawa, Takashi Ibuka, Miki Miura, Yu Sasaki, Sakuma Takahashi, Hiroshi Nakase, Hiroki Kiyohara, Keiichi Tominaga, Yosuke Shimodaira, Sakiko Hiraoka, Nobuhiro Ueno, Shunichi Yanai, Takeo Yoshihara, Kazuki Kakimoto, Katsuyoshi Matsuoka, Ryohei Hayashi, Sohachi Nanjo, Itaru Iwama, Yoh Ishiguro, Hirofumi Chiba, Katsuya Endo, Takashi Kagaya, Tomohiro Fukuda, Yasuhisa Sakata, Takahiro Kudo, Tomohisa Takagi, Kenichi Takahashi, Makoto Naganuma, Masaru Shinozaki, Noriyuki Ogata, Hiroki Tanaka, Kazuyuki Narimatsu, Haruka Miyazaki, Takashi Ishige, Motoyuki Onodera, Yu Hashimoto, Hiroshi Nagai, Yusuke Shimoyama, Takeo Naito, Rintaro Moroi, Hisashi Shiga, , Yoshitaka Kinouchi, Akira Andoh, Tadakazu Hisamatsu, Atsushi Masamune: Real-world NUDT15 genotyping and thiopurine treatment optimization in inflammatory bowel disease: a multicenter study. J Gastroenterol. 2024.04; Online ahead of print ( PubMed , DOI )

  3. Nobuhiko Ogasawara, Yoshihito Kano, Yosuke Yoneyama, Sakurako Kobayashi, Satoshi Watanabe, Sakura Kirino, Fausto D Velez-Bravo, Yourae Hong, Aleksandra Ostapiuk, Pavlo Lutsik, Iichiroh Onishi, Shinichi Yamauchi, Yui Hiraguri, Go Ito, Yusuke Kinugasa, Kenichi Ohashi, Mamoru Watanabe, Ryuichi Okamoto, Sabine Tejpar, Shiro Yui: Discovery of non-genomic drivers of YAP signaling modulating the cell plasticity in CRC tumor lines. iScience. 2024.03; 27 (3): 109247. ( PubMed , DOI )

  4. Tatsuya Suzuki, Yuka Hayakawa, Shun Kaneko, Kento Takenaka, Keiya Watakabe, Yuko Kinowaki, Akira Takemoto, Kazuo Ohtsuka, Yasuhiro Asahina, Ryuichi Okamoto: Granulomatous hepatitis with Crohn's disease: a case report. Clin J Gastroenterol. 2024.03; Online ahead of print ( PubMed , DOI )

  5. Shintaro Akiyama, Kaoru Yokoyama, Soichi Yagi, Shinichiro Shinzaki, Kozo Tsuruta, Shinichiro Yoshioka, Minako Sako, Hiromichi Shimizu, Mariko Kobayashi, Toshiyuki Sakurai, Kei Nomura, Tomoyoshi Shibuya, Masahiro Takahara, Sakiko Hiraoka, Kyohei Sugai, Shunichi Yanai, Atsushi Yoshida, Miki Koroku, Teppei Omori, Masayuki Saruta, Takayuki Matsumoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Toshimitsu Fujii: Efficacy and safety of filgotinib for ulcerative colitis: A real-world multicenter retrospective study in Japan. Aliment Pharmacol Ther. 2024.03; Online ahead of print ( PubMed , DOI )

  6. Keito Suzuki, Yutaka Yasui, Kaoru Tsuchiya, Hiroaki Matsumoto, Yudai Yamazaki, Naoki Uchihara, Yuki Tanaka, Haruka Miyamoto, Michiko Yamada-Shimizu, Taisei Keitoku, Risa Okada, Mayu Higuchi, Kenta Takaura, Shohei Tanaka, Chiaki Maeyashiki, Nobuharu Tamaki, Hiroyuki Nakanishi, Yuka Takahashi, Yasuhiro Asahina, Ryuichi Okamoto, Masayuki Kurosaki, Namiki Izumi: Impact of immune-related adverse events in patients with hepatocellular carcinoma treated with atezolizumab plus bevacizumab. J Gastroenterol Hepatol. 2024.03; Online ahead of print ( PubMed , DOI )

  7. Marc Ferrante, Peter M Irving, Maria T Abreu, Jeffrey Axler, Xiang Gao, Qian Cao, Toshimitsu Fujii, Astrid Rausch, Joana Torres, Ezequiel Neimark, Alexandra Song, Kori Wallace, Kristina Kligys, Sofie Berg, Xiaomei Liao, Qing Zhou, Jasmina Kalabic, Brian Feagan, Remo Panaccione: Maintenance Risankizumab Sustains Induction Response in Patients with Crohn's Disease in a Randomized Phase 3 Trial. J Crohns Colitis. 2024.03; 18 (3): 416-423. ( PubMed , DOI )

  8. Makoto Naganuma, Naohiro Nakamura, Reiko Kunisaki, Katsuyoshi Matsuoka, Shojiro Yamamoto, Ami Kawamoto, Daisuke Saito, Taku Kobayashi, Kosaku Nanki, Kazuyuki Narimatsu, Hisashi Shiga, Motohiro Esaki, Shinichiro Yoshioka, Shingo Kato, Masayuki Saruta, Shinji Tanaka, Eriko Yasutomi, Kaoru Yokoyama, Kei Moriya, Yoshikazu Tsuzuki, Makoto Ooi, Mikihiro Fujiya, Atsushi Nakazawa, Tomohisa Takagi, Teppei Omori, Toshiyuki Tahara, Tadakazu Hisamatsu & The Japanese UC Study Group : Medical treatment selection and outcomes for hospitalized patients with severe ulcerative colitis as defined by the Japanese criteria. J Gastroenterol. 2024.01; Online ahead of print ( PubMed , DOI )

  9. Xiang Gao, Toshimitsu Fujii, Byong Duk Ye, Jen-Wei Chou, Ken Sugimoto, Qian Cao, Kristina Kligys, Kaoru Murakoshi, Dennis Teng, Yafei Zhang, Hiroshi Nakase: Efficacy and safety of risankizumab for Crohn's disease in patients from Asian countries: a post hoc subanalysis of the global phase 3 ADVANCE, MOTIVATE, and FORTIFY studies. J Gastroenterol Hepatol. 2024.01; 39 (1): 55-65. ( PubMed , DOI )

  10. Shun Kaneko, Yasuhiro Asahina, Miyako Murakawa, Seishin Azuma, Kento Inada, Tomohiro Mochida, Keiya Watakabe, Taro Shimizu, Jun Tsuchiya, Masato Miyoshi, Fukiko Kawai-Kitahata, Sayuri Nitta, Marie Takahashi, Tomoyuki Fujioka, Mitsuhiro Kishino, Tatsuhiko Anzai, Sei Kakinuma, Mina Nakagawa, Ryuichi Okamoto: Analysis of prognosis and background liver disease in non-advanced hepatocellular carcinoma in two decades. PLoS One. 2024; 19 (3): e0297882. ( PubMed , DOI )

  1. Makoto Naganuma, Taku Kobayashi, Reiko Kunisaki, Katsuyoshi Matsuoka, Shojiro Yamamoto, Ami Kawamoto, Daisuke Saito, Kosaku Nanki, Kazuyuki Narimatsu, Hisashi Shiga, Motohiro Esaki, Shinichiro Yoshioka, Shingo Kato, Masayuki Saruta, Shinji Tanaka, Eriko Yasutomi, Kaoru Yokoyama, Kei Moriya, Yoshikazu Tsuzuki, Makoto Ooi, Mikihiro Fujiya, Atsushi Nakazawa, Takayuki Abe, Tadakazu Hisamatsu, : Real-world efficacy and safety of advanced therapies in hospitalized patients with ulcerative colitis. J Gastroenterol. 2023.12; 58 (12): 1198-1210. ( PubMed , DOI )

  2. Nanako Hashido, Masanori Kobayashi, Ami Kawamoto, Suguru Mabuchi, Hiromune Katsuda, Kazuo Ohtsuka, Yasuhiro Asahina, Masayoshi Hashimoto, Ryuichi Okamoto: Sphincter of Oddi dysfunction that could not be diagnosed with Rome IV: a case report. Clin J Gastroenterol. 2023.12; 16 (6): 913-918. ( PubMed , DOI )

  3. Shun Kaneko, Yasuhiro Asahina, Miyako Murakawa, Shunsuke Ueyama, Chiaki Maeyashiki, Hideki Watanabe, Akiko Kusano-Kitazume, Ayako Sato, Kozue Uchidate, Takehito Asakawa, Sho Watanabe, Yasuhiro Iizuka, Isamu Shibata, Shinya Oooka, Yuko Karakama, Takashi Fujii, Taro Watabe, Keiichi Akahoshi, Minoru Tanabe, Kento Inada, Tomohiro Mochida, Keiya Watakabe, Taro Shimizu, Jun Tsuchiya, Masato Miyoshi, Fukiko Kitahata-Kawai, Sayuri Nitta, Mina Nakagawa, Sei Kakinuma, Ryuichi Okamoto, : Prognostic Significance of C-Reactive Protein in Unresectable Hepatocellular Carcinoma treated with Atezolizumab and Bevacizumab. Hepatol Res. 2023.12; Online ahead of print. ( PubMed , DOI )

  4. Laurent Peyrin-Biroulet, Jessica R Allegretti, David T Rubin, Brian Bressler, Matthew Germinaro, Kuan-Hsiang Gary Huang, Nicole Shipitofsky, Hongyan Zhang, Rebbecca Wilson, Chenglong Han, Brian G Feagan, William J Sandborn, Julian Panés, Tadakazu Hisamatsu, Gary R Lichtenstein, Bruce E Sands, Axel Dignass ; QUASAR Study Group: Guselkumab in Patients With Moderately to Severely Active Ulcerative Colitis: QUASAR Phase 2b Induction Study. Gastroenterology. 2023.12; 165 (6): 1443-1457. ( PubMed , DOI )

  5. Haruki Uojima, Kadzuki Nakabayashi, Kazumi Yamasaki, Masaya Sugiyama, Norihiro Ishii, Ken Shirabe, Takuya Kyoutou, Koji Ueda, Yoichi Takahama, Nobuharu Tamaki, Masayuki Kurosaki, Hisashi Hidaka, Chika Kusano, Keisuke Amano, Takumi Kawaguchi, Akinobu Taketomi, Satoru Joshita, Takeji Umemura, Miyako Murakawa, Yasuhiro Asahina, Takanori Suzuki, Kentaro Matsuura, Takashi Nishimura, Hiroko Iijima, Kazumasa Sakamoto, Kiyoaki Ito, Sohji Nishina, Keisuke Hino, Hidenori Toyoda, Hiroshi Yatsuhashi, Masayoshi Kage, Masashi Mizokami: New chemiluminescent enzyme immunoassay for quantitative measurement of Mac-2 binding protein glycosylation isomer in chronic liver disease. J Gastroenterol. 2023.12; 58 (12): 1252-1260. ( PubMed , DOI )

  6. Yuki Tahata, Hayato Hikita, Satoshi Mochida, Nobuyuki Enomoto, Akio Ido, Hidekatsu Kuroda, Daiki Miki, Masayuki Kurosaki, Yoichi Hiasa, Ryotaro Sakamori, Norifumi Kawada, Taro Yamashita, Goki Suda, Hiroshi Yatsuhashi, Hitoshi Yoshiji, Naoya Kato, Taro Takami, Kazuhiko Nakao, Kentaro Matsuura, Yasuhiro Asahina, Yoshito Itoh, Ryosuke Tateishi, Yasunari Nakamoto, Eiji Kakazu, Shuji Terai, Masahito Shimizu, Yoshiyuki Ueno, Norio Akuta, Masanori Miyazaki, Yasutoshi Nozaki, Masayuki Kabayama, Satoshi Sobue, Akihiro Moriuchi, Tomokatsu Miyaki, Takahiro Kodama, Tomohide Tatsumi, Tomomi Yamada, Tetsuo Takehara: Posttreatment liver function, but not baseline liver function stratifies patient survival after direct-acting antiviral treatment in decompensated cirrhosis with hepatitis C virus. J Gastroenterol. 2023.12; 58 (12): 1211-1221. ( PubMed , DOI )

  7. Shuji Hibiya, Takashi Fujii, Toshimitsu Fujii, Shinji Suzuki, Mayumi Kondo, Shinya Ooka, Yohei Furumoto, Seishin Azuma, Kei Tanaka, Hitoshi Kurata, Shohei Tanaka, Masayuki Kurosaki, Kazuyoshi Nagayama, Fumihiko Kusano, Yasuhiro Iizuka, Takahiro Kawamura, Hidekazu Ikemiyagi, Shinya Sakita, Tsunehito Yauchi, Hideki Watanabe, Ami Kawamoto, Yusuke Matsuyama, Kazuo Ohtsuka, Ryuichi Okamoto: COVID-19 severity is associated with the risk of gastrointestinal bleeding. BMJ Open Gastroenterol. 2023.11; 10 (1): ( PubMed , DOI )

  8. Ami Kawamoto, Kento Takenaka, Shuji Hibiya, Yoshio Kitazume, Hiromichi Shimizu, Toshimitsu Fujii, Eiko Saito, Kazuo Ohtsuka, Ryuichi Okamoto: Combination of leucine-rich alpha-2 glycoprotein and fecal markers detect Crohn's disease activity confirmed by balloon-assisted enteroscopy. Intest Res. 2023.11; Online ahead of print ( PubMed , DOI )

  9. Miwa Himuro, Yuka Wakabayashi, Tomomi Taguchi, Takehiro Katahira, Luka Suzuki, Hitoshi Iida, Takeshi Ogihara, Yuya Nishida, Shugo Sasaki, Francis C Lynn, Yuichi Hiraoka, Shigeru Oshima, Ryuichi Okamoto, Yoshio Fujitani, Hirotaka Watada, Takeshi Miyatsuka: Novel time-resolved reporter mouse reveals spatial and transcriptional heterogeneity during alpha cell differentiation. Diabetologia. 2023.10; ( PubMed , DOI )

  10. Masanori Kobayashi, Hiromune Katsuda, Kazuo Ohtsuka, Ryuichi Okamoto: Comparison of guidewires for successful cannulation of biliary stenosis and targeting of biliary branches in ERCP. Endosc Int Open. 2023.09; 11 (9): E805-E810. ( PubMed , DOI )

  11. Kirino Sakura, Tamaki Nobuharu, Kurosaki Masayuki, Takahashi Yuka, Higuchi Mayu, Itakura Yoshie, Tanaka Yuki, Inada Kento, Ishido Shun, Yamashita Koji, Nobusawa Tsubasa, Matsumoto Hiroaki, Hayakawa Yuka, Kakegawa Tatsuya, Takaura Kenta, Tanaka Shohei, Maeyashiki Chiaki, Kaneko Shun, Yasui Yutaka, Tsuchiya Kaoru, Nakanishi Hiroyuki, Okamoto Ryuichi, Izumi Namiki: Detecting advanced liver fibrosis using ultrasound shear wave velocity measurement in the general population QUANTITATIVE IMAGING IN MEDICINE AND SURGERY. 2023.08; 13 (10): 6493-6502. ( PubMed , DOI )

  12. Kentaro Miyamoto, Tomohisa Sujino, Yosuke Harada, Hiroshi Ashida, Yusuke Yoshimatsu, Yuki Yonemoto, Yasuhiro Nemoto, Michio Tomura, Hassan Melhem, Jan Hendrik Niess, Toshihiko Suzuki, Toru Suzuki, Shohei Suzuki, Yuzo Koda, Ryuichi Okamoto, Yohei Mikami, Toshiaki Teratani, Kenji F. Tanaka, Akihiko Yoshimura, Toshiro Sato, Takanori Kanai: The gut microbiota-induced kynurenic acid recruits GPR35-positive macrophages to promote experimental encephalitis. Cell Rep. 2023.08; 42 (8): 113005. ( PubMed , DOI )

  13. Takayuki Yamamoto, Hiroshi Nakase, Kenji Watanabe, Shinichiro Shinzaki, Noritaka Takatsu, Toshimitsu Fujii, Ryuichi Okamoto, Katsuyoshi Matsuoka, Akihiro Yamada, Reiko Kunisaki, Minoru Matsuura, Hisashi Shiga, Shigeki Bamba, Yohei Mikami, Takahiro Shimoyama, Satoshi Motoya, Takehiro Torisu, Taku Kobayashi, Naoki Ohmiya, Masayuki Saruta, Koichiro Matsuda, Takayuki Matsumoto, Atsuo Maemoto, Yoko Murata, Shinichi Yoshigoe, Shinya Nagasaka, Tsutomu Yajima, Tadakazu Hisamatsu, : Diagnosis and Clinical Features of Perianal Lesions in Newly Diagnosed Crohn's Disease: Subgroup Analysis from Inception Cohort Registry Study of Patients with Crohn's Disease (iCREST-CD). J Crohns Colitis. 2023.08; 17 (8): 1193-1206. ( PubMed , DOI )

  14. Morimoto K, Ueda H, Asano D, Ishikawa Y, Watanabe S, Akahoshi K, Ono H, Kobayashi M, Okamoto R, Tanaka S, Tanabe M: Incidence and Mechanism of Refractory Postoperative Cholangitis After Hepatectomy with Hepaticojejunostomy. J Gastrointest Surg. 2023.08; 27 (8): 1668-1676. ( PubMed , DOI )

  15. Katsuyoshi Matsuoka, Hajime Yamazaki, Masakazu Nagahori, Taku Kobayashi, Teppei Omori, Yohei Mikami, Toshimitsu Fujii, Shinichiro Shinzaki, Masayuki Saruta, Minoru Matsuura, Takayuki Yamamoto, Satoshi Motoya, Toshifumi Hibi, Mamoru Watanabe, Jovelle Fernandez, Shunichi Fukuhara, Tadakazu Hisamatsu: Association of ulcerative colitis symptom severity and proctocolectomy with multidimensional patient-reported outcomes: a cross-sectional study. J Gastroenterol. 2023.08; 58 (8): 751-765. ( PubMed , DOI )

  16. Takeshi Ueda, Fumikazu Koyama, Akira Sugita, Hiroki Ikeuchi, Kitaro Futami, Kouhei Fukushima, Riichiro Nezu, Hideki Iijima, Tsunekazu Mizushima, Michio Itabashi, Kazuhiro Watanabe, Keisuke Hata, Takahide Shinagawa, Katsuyoshi Matsuoka, Kento Takenaka, Makoto Sasaki, Manabu Nagayama, Hironori Yamamoto, Masaru Shinozaki, Mikihiro Fujiya, Jun Kato, Yoshitaka Ueno, Shinji Tanaka, Yoshiki Okita, Yoshinari Hashimoto, Taku Kobayashi, Kazutaka Koganei, Motoi Uchino, Hisao Fujii, Yasuo Suzuki, Tadakazu Hisamatsu: Endoscopic lesions of postoperative anastomotic area in patients with Crohn's disease in the biologic era: A Japanese multi-center nationwide cohort study. J Crohns Colitis. 2023.07; ( PubMed , DOI )

  17. Yoshio Kitazume, Kento Takenaka, Kazuo Ohtsuka, Yasuo Ozawa, Koichiro Kimura, Ryosuke Watanabe, Junichi Tsuchiya, Toshimitsu Fujii, Masakazu Nagahori, Mamoru Watanabe, Ukihide Tateishi: Motility Mapping Quantification Using the Classical Optical Flow Algorithm for Small Bowel Crohn's Disease: Comparison with Balloon-assisted Enteroscopy Findings. Magn Reson Med Sci. 2023.07; 22 (3): 325-334. ( PubMed , DOI )

  18. Kento Takenaka, Ami Kawamoto, Yoshio Kitazume, Toshimitsu Fujii, Yumi Udagawa, Hiromichi Shimizu, Shuji Hibiya, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto: Transmural Remission Characterized by High Biologic Concentrations Demonstrates Better Prognosis in Crohn's Disease. J Crohns Colitis. 2023.06; 17 (6): 855-862. ( PubMed , DOI )

  19. Kento Takenaka, Yoshio Kitazume, Ami Kawamoto, Toshimitsu Fujii, Yumi Udagawa, Ryosuke Wanatabe, Hiromichi Shimizu, Shuji Hibiya, Masakazu Nagahori, Kazuo Ohtsuka, Hiroyuki Sato, Akihiro Hirakawa, Mamoru Watanabe, Ryuichi Okamoto: Serum Leucine-Rich α2 Glycoprotein: A Novel Biomarker for Transmural Inflammation in Crohn's Disease. Am J Gastroenterol. 2023.06; 118 (6): 1028-1035. ( PubMed , DOI )

  20. Shun Fujiwara, Yoshihito Kano, Yasuhiro Maejima, Tomoyuki Fujioka, Kazuhiro Tamura, Susumu Kirimura, Satoshi Miyake, Ryuichi Okamoto: Clinical Response of Primary Malignant Pericardial Mesothelioma with Peritoneal Dissemination to Nivolumab. Intern Med. 2023.06; Online ahead of print ( PubMed , DOI )

  21. Katsuyoshi Matsuoka, Toshimitsu Fujii, Ryuichi Okamoto, Akihiro Yamada, Reiko Kunisaki, Minoru Matsuura, Kenji Watanabe, Hisashi Shiga, Noritaka Takatsu, Shigeki Bamba, Yohei Mikami, Takayuki Yamamoto, Takahiro Shimoyama, Satoshi Motoya, Takehiro Torisu, Taku Kobayashi, Naoki Ohmiya, Masayuki Saruta, Koichiro Matsuda, Takayuki Matsumoto, Hiroshi Nakase, Atsuo Maemoto, Shinichiro Shinzaki, Yoko Murata, Shinichi Yoshigoe, Ayako Sasaki, Tsutomu Yajima, Tadakazu Hisamatsu, : Correction: Characteristics of adult patients newly diagnosed with Crohn's disease: interim analysis of the nation-wide inception cohort registry study of patients with Crohn's disease in Japan (iCREST-CD). J Gastroenterol. 2023.06; 58 (6): 602-603. ( PubMed , DOI )

  22. Junichi Takahashi, Hady Yuki Sugihara, Shu Kato, Sayaka Nagata, Ryuichi Okamoto, Tomohiro Mizutani: Protocol to generate large human intestinal organoids using a rotating bioreactor. STAR Protocols. 2023.06; 4 (3): 102374. ( PubMed , DOI )

  23. Sylvia Leo, Yusuke Kato, Yu Meng Wu, Mutsumi Yokota, Masato Koike, Shiro Yui, Kiichiro Tsuchiya, Nobuaki Shiraki, Shoen Kume: The effect of Vitamin D3 and Valproic Acid on the maturation of human induced pluripotent stem cell-derived enterocyte-like cells. Stem Cells. 2023.05; ( PubMed , DOI )

  24. Kaneko Shun, Asahina Yasuhiro, Nakagawa Mina, Murakawa Miyako, Miyazaki Yasunari, Asakage Takahiro, Fukuda Shohei, Namiki Takeshi, Kano Yoshihito, Nagata Masashi, Tsuchiya Jun, Miyoshi Masato, Kitahata-Kawai Fukiko, Nitta Sayuri, Itsui Yasuhiro, Kakinuma Sei, Okamoto Ryuichi: Factors associated with liver injury and prognosis in advanced cancer patients treated with immune checkpoint inhibitors(タイトル和訳中) Hepatology Research. 2023.05; 53 (5): 450-459. ( ichushi )

  25. Fujiwara S, Kawamoto A, Motobayashi M, Hibiya S, Takenaka K, Shimizu H, Saito E, Fujii T, Nagahori M, Kawata D, Umezawa N, Hosoya T, Yasuda S, Ohtsuka K, Okamoto R: Hemorrhagic gastric ulcer in a patient with Behcet's disease successfully treated with infliximab. DEN open. 2023.04; 3 (1): e196. ( PubMed , DOI )

  26. Mina Nakagawa, Yasuhiro Asahina, Sei Kakinuma, Ryuichi Okamoto: Impact of eradication of hepatitis C virus on liver-related and -unrelated diseases: morbidity and mortality of chronic hepatitis C after SVR. J Gastroenterol. 2023.04; 58 (4): 299-310. ( PubMed , DOI )

  27. Hiroshi Nakase, Motohiro Esaki, Fumihito Hirai, Taku Kobayashi, Katsuyoshi Matsuoka, Minoru Matsuura, Makoto Naganuma, Masayuki Saruta, Kiichiro Tsuchiya, Motoi Uchino, Kenji Watanabe, Tadakazu Hisamatsu, : Treatment escalation and de-escalation decisions in Crohn's disease: Delphi consensus recommendations from Japan, 2021. J Gastroenterol. 2023.04; 58 (4): 313-345. ( PubMed , DOI )

  28. Satoshi Watanabe, Nobuhiko Ogasawara, Sakurako Kobayashi, Sakura Kirino, Masami Inoue, Yui Hiraguri, Sayaka Nagata, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Yasuhiro Nemoto, Kiichiro Tsuchiya, Ryuichi Okamoto, Mamoru Watanabe, Shiro Yui: Organoids transplantation as a new modality to design epithelial signature to create a membrane-protective sulfomucin-enriched segment. J Gastroenterol. 2023.04; 58 (4): 379-393. ( PubMed , DOI )

  29. Taisei Keitoku, Nobuharu Tamaki, Masayuki Kurosaki, Kento Inada, Sakura Kirino, Naoki Uchihara, Keito Suzuki, Yuki Tanaka, Haruka Miyamoto, Shun Ishido, Michiko Yamada, Tsubasa Nobusawa, Hiroaki Matsumoto, Mayu Higuchi, Kenta Takaura, Shohei Tanaka, Chiaki Maeyashiki, Shun Kaneko, Yutaka Yasui, Yuka Takahashi, Kaoru Tsuchiya, Hiroyuki Nakanishi, Yasuhiro Asahina, Ryuichi Okamoto, Namiki Izumi: Effect of fatty liver and fibrosis on hepatocellular carcinoma development in patients with chronic hepatitis B who received nucleic acid analog therapy. J Viral Hepat. 2023.04; 30 (4): 297-302. ( PubMed , DOI )

  30. Mina Nakagawa, Yasuhiro Asahina, Sei Kakinuma, Ryuichi Okamoto: Correction: Impact of eradication of hepatitis C virus on liver-related and -unrelated diseases: morbidity and mortality of chronic hepatitis C after SVR. J Gastroenterol. 2023.04; 58 (4): 311-312. ( PubMed , DOI )

  31. Daiki Yamada, Yudai Kojima, Akinori Hosoya, Masahiro Suzuki, Taro Watabe, Tadahiko Inoue, Naoya Tsugawa, Takehito Asakawa, Yuki Yonemoto, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Motoyuki Shimonaka, Keiji Kuba, Junji Ishida, Akiyoshi Fukamizu, Josef M Penninger, Mamoru Watanabe, Ryuichi Okamoto, Takashi Nagaishi: Apelin expression is downregulated in T cells in a murine model of chronic colitis. Biochem Biophys Res Commun. 2023.03; 647 72-79. ( PubMed , DOI )

  32. Saito E, Ohtsuka K, Kawamoto A, Fujii T, Takenaka K, Hibiya S, Shimizu H, Nagahori M, Tomii S, Okamoto R: A case of venous stasis colitis possibly caused by eplerenone. Clinical journal of gastroenterology. 2023.02; 16 (1): 69-72. ( PubMed , DOI )

  33. Satoshi Watanabe, Nobuhiko Ogasawara, Sakurako Kobayashi, Sakura Kirino, Masami Inoue, Yui Hiraguri, Sayaka Nagata, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Yasuhiro Nemoto, Kiichiro Tsuchiya, Ryuichi Okamoto, Mamoru Watanabe, Shiro Yui: Organoids transplantation as a new modality to design epithelial signature to create a membrane-protective sulfomucin-enriched segment. J Gastroenterol. 2023.02; ( PubMed , DOI )

  34. Toshiaki Shibata, Daisuke Shinjo, Junichi Takahashi, Kiyohide Fushimi: Pandemic-resilient target setting in colorectal cancer screening for vulnerable older population. Cancer Med. 2023.01; 12 (1): 619-630. ( PubMed , DOI )

  35. Tetsuro Shimakami, Hiroko Setoyama, Noriko Oza, Jun Itakura, Shun Kaneko, Masaaki Korenaga, Tadashi Toyama, Junko Tanaka, Tatsuya Kanto: Development of performance indicators for hepatitis countermeasures as a tool for the assessment and promotion of liver cancer prevention in Japan. J Gastroenterol. 2023.01; 1-11. ( PubMed , DOI )

  36. Shun Kaneko, Masayuki Kurosaki, Toshie Mashiba, Hiroyuki Marusawa, Masahiko Kondo, Yuji Kojima, Yasushi Uchida, Hideki Fujii, Takehiro Akahane, Hitoshi Yagisawa, Atsunori Kusakabe, Haruhiko Kobashi, Takehiko Abe, Hideo Yoshida, Chikara Ogawa, Koichiro Furuta, Nobuharu Tamaki, Keiji Tsuji, Tomomichi Matsushita, Namiki Izumi, : Risk factors for hepatocellular carcinoma at baseline and 1 year after initiation of nucleos(t)ide analog therapy for chronic hepatitis B. J Med Virol. 2023.01; 95 (1): e28210. ( PubMed , DOI )

  37. Kaneko S, Asahina Y, Nakagawa M, Murakawa M, Miyazaki Y, Asakage T, Fukuda S, Namiki T, Kano Y, Nagata M, Tsuchiya J, Miyoshi M, Kitahata-Kawai F, Nitta S, Itsui Y, Kakinuma S, Okamoto R: Factors associated with liver injury and prognosis in advanced cancer patients treated with immune checkpoint inhibitors. Hepatology research : the official journal of the Japan Society of Hepatology. 2023.01; 53 (5): 450-459. ( PubMed , DOI )

  38. Ryuichi Okamoto, Tomohiro Mizutani, Hiromichi Shimizu: Development and Application of Regenerative Medicine in Inflammatory Bowel Disease. Digestion. 2023; 104 (1): 24-29. ( PubMed , DOI )

  39. Shokichi Takahama, Sachiyo Yoshio, Yuji Masuta, Hirotomo Murakami, Ryotaro Sakamori, Shun Kaneko, Takashi Honda, Miyako Murakawa, Masaya Sugiyama, Masayuki Kurosaki, Yasuhiro Asahina, Tetsuo Takehara, Victor Appay, Tatsuya Kanto, Takuya Yamamoto: Hepatitis B surface antigen reduction is associated with hepatitis B core-specific CD8+ T cell quality Front Immunol. 2023; 14 1257113. ( PubMed , DOI )

  1. Takahashi J, Mizutani T, Sugihara HY, Nagata S, Kato S, Hiraguri Y, Takeoka S, Tsuchiya M, Kuno R, Kakinuma S, Watanabe M, Okamoto R: Suspension culture in a rotating bioreactor for efficient generation of human intestinal organoids. Cell Reports Methods. 2022.11; 2 (11): 100337. ( PubMed , DOI )

  2. Katsuyoshi Matsuoka, Toshimitsu Fujii, Ryuichi Okamoto, Akihiro Yamada, Reiko Kunisaki, Minoru Matsuura, Kenji Watanabe, Hisashi Shiga, Noritaka Takatsu, Shigeki Bamba, Yohei Mikami, Takayuki Yamamoto, Takahiro Shimoyama, Satoshi Motoya, Takehiro Torisu, Taku Kobayashi, Naoki Ohmiya, Masayuki Saruta, Koichiro Matsuda, Takayuki Matsumoto, Hiroshi Nakase, Atsuo Maemoto, Shinichiro Shinzaki, Yoko Murata, Shinichi Yoshigoe, Ayako Sasaki, Tsutomu Yajima, Tadakazu Hisamatsu: Characteristics of adult patients newly diagnosed with Crohn's disease: interim analysis of the nation-wide inception cohort registry study of patients with Crohn's disease in Japan (iCREST-CD). J Gastroenterol. 2022.11; 57 (11): 867-878. ( PubMed , DOI )

  3. Ami Kawamoto, Kento Takenaka, Ryuichi Okamoto, Mamoru Watanabe, Kazuo Ohtsuka: Systematic review of artificial intelligence-based image diagnosis for inflammatory bowel disease. Dig Endosc. 2022.11; 34 (7): 1311-1319. ( PubMed , DOI )

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  2. Kaneko S, Kurosaki M, Sugiyama T, Takahashi Y, Yamaguchi Y, Nagasawa M, Izumi N.: The dynamics of quantitative SARS-CoV-2 antispike IgG response to BNT162b2 vaccination J Med Virol. 2021.12; 93 (12): 6813-6817.

  3. Kento Takenaka, Toshimitsu Fujii, Ami Kawamoto, Kohei Suzuki, Hiromichi Shimizu, Chiaki Maeyashiki, Osamu Yamaji, Maiko Motobayashi, Akira Igarashi, Ryoichi Hanazawa, Shuji Hibiya, Masakazu Nagahori, Eiko Saito, Ryuichi Okamoto, Kazuo Ohtsuka, Mamoru Watanabe: Deep neural network for video colonoscopy of ulcerative colitis: a cross-sectional study. Lancet Gastroenterol Hepatol. 2021.11; ( PubMed , DOI )

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  5. Noriyuki Ogata, Kazuo Ohtsuka, Masataka Ogawa, Yasuharu Maeda, Fumio Ishida, Shin-Ei Kudo: Image-Enhanced Capsule Endoscopy Improves the Identification of Small Intestinal Lesions. Diagnostics (Basel). 2021.11; 11 (11): ( PubMed , DOI )

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  7. Kento Takenaka, Ami Kawamoto, Kazuo Ohtsuka: Editorial: higher concentrations of cytokine blockers are needed to obtain small bowel mucosal healing during maintenance therapy in Crohn's disease-authors' reply. Aliment Pharmacol Ther. 2021.10; 54 (8): 1087. ( PubMed , DOI )

  8. Yuka Hayakawa, Kaoru Tsuchiya, Masayuki Kurosaki, Yutaka Yasui, Shun Kaneko, Yuki Tanaka, Shun Ishido, Kento Inada, Sakura Kirino, Koji Yamashita, Tsubasa Nobusawa, Hiroaki Matsumoto, Tatsuya Kakegawa, Mayu Higuchi, Kenta Takaura, Shohei Tanaka, Chiaki Maeyashiki, Nobuharu Tamaki, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi , Yasuhiro Asahina, Ryuichi Okamoto, Namiki Izumi: Early experience of atezolizumab plus bevacizumab therapy in Japanese patients with unresectable hepatocellular carcinoma in real-world practice Investigational New Drugs. 2021.10;

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  12. Kaneko S, Kurosaki M, Tsuchiya K, Yasui Y, Inada K, Kirino S, Yamashita K, Osawa L, Hayakawa Y, Sekiguchi S, Higuchi M, Takaura K, Maeyashiki C, Tamaki N, Itakura J, Takahashi Y, Nakanishi H, Asano D, Irie T, Kawachi Y, Izumi N.: Prognosis of intrahepatic cholangiocarcinoma stratified by albumin-bilirubin grade Hepatol Res. 2021.08; 51 (8): 902-908.

  13. Inada K, Kaneko S, Kurosaki M, Yamashita K, Kirino S, Osawa L, Hayakawa Y, Sekiguchi S, Higuchi M, Takaura K, Maeyashiki C, Tamaki N, Yasui Y, Itakura J, Takahashi Y, Tsuchiya K, Nakanishi H, Okamoto R, Izumi N.: Tenofovir alafenamide for prevention and treatment of hepatitis B virus reactivation and de novo hepatitis. JGH Open. 2021.08; 19 (5): 1085-1091.

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  1. Fukiko Kawai-Kitahata, Yasuhiro Asahina, Shun Kaneko, Jun Tsuchiya, Ayako Sato, Masato Miyoshi, Tomoyuki Tsunoda, Emi Inoue-Shinomiya, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Sei Kakinuma, Minoru Tanabe, Emiko Sugawara, Akira Takemoto, Hidenori Ojima, Michiie Sakamoto, Masaru Muraoka, Shinichi Takano, Shinya Maekawa, Nobuyuki Enomoto, Mamoru Watanabe: Comprehensive genetic analysis of cholangiolocellular carcinoma with a coexistent hepatocellular carcinoma-like area and metachronous hepatocellular carcinoma. Hepatol Res. 2019.12; 49 (12): 1466-1474. ( PubMed , DOI )

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  15. Emi Inoue-Shinomiya, Miyako Murakawa, Yasuhiro Asahina, Mina Nakagawa, Jun Tsuchiya, Ayako Sato, Tomoyuki Tsunoda, Masato Miyoshi, Sayuri Nitta, Fukiko Kawai-Kitahata, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Kazumoto Murata, Masashi Mizokami, Mamoru Watanabe: Association of serum interferon-λ3 levels with hepatocarcinogenesis in chronic hepatitis C patients treated with direct-acting antiviral agents. Hepatol. Res.. 2019.05; 49 (5): 500-511. ( PubMed , DOI )

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  1. Yuki Tanisaka, Shomei Ryozawa, Masafumi Mizuide, Masanori Kobayashi, Akashi Fujita, Kazuhiro Minami, Tsutomu Kobatake, Kumiko Omiya, Hirotoshi Iwano, Ryuichiro Araki: Usefulness of the "newly designed" short-type single-balloon enteroscope for ERCP in patients with Roux-en-Y gastrectomy: a pilot study. Endosc Int Open. 2018.12; 6 (12): E1417-E1422. ( PubMed , DOI )

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  6. Shinichiro Shinzaki, Toshimitsu Fujii, Shigeki Bamba, Maiko Ogawa, Taku Kobayashi, Masahide Oshita, Hiroki Tanaka, Keiji Ozeki, Sakuma Takahashi, Hiroki Kitamoto, Kazuhito Kani, Sohachi Nanjo, Takeshi Sugaya, Yuko Sakakibara, Toshihiro Inokuchi, Kazuki Kakimoto, Akihiro Yamada, Hisae Yasuhara, Yoko Yokoyama, Takuya Yoshino, Akira Matsui, Misaki Nakamura, Taku Tomizawa, Ryosuke Sakemi, Noriko Kamata, Toshifumi Hibi: Seven days triple therapy for eradication of Helicobacter pylori does not alter the disease activity of patients with inflammatory bowel disease. Intest Res. 2018.10; 16 (4): 609-618. ( PubMed , DOI )

  7. Hosoe N, Ohtsuka K, Endo Y, Naganuma M, Ogata N, Kuroki Y, Sasanuma S, Takabayashi K, Kudo SE, Takahashi H, Ogata H, Kanai T: Insertability comparison of passive bending single-balloon prototype versus standard single-balloon enteroscopy: a multicenter randomized non-blinded trial. Endoscopy international open. 2018.10; 6 (10): E1184-E1189. ( PubMed , DOI )

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  12. Michael G Kattah, Ling Shao, Yenny Y Rosli, Hiromichi Shimizu, Michael I Whang, Rommel Advincula, Philip Achacoso, Sanjana Shah, Bao H Duong, Michio Onizawa, Priscilia Tanbun, Barbara A Malynn, Averil Ma: A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival. J. Exp. Med. 2018.07; 215 (7): 1839-1852. ( PubMed , DOI )

  13. Fumihiko Iwamoto, Katsuyoshi Matsuoka, Maiko Motobayashi, Kento Takenaka, Toru Kuno, Keisuke Tanaka, Yuya Tsukui, Shoji Kobayashi, Takashi Yoshida, Toshimitsu Fujii, Eiko Saito, Tatsuya Yamaguchi, Masakazu Nagahori, Tadashi Sato, Kazuo Ohtsuka, Nobuyuki Enomoto, Mamoru Watanabe: Prediction of disease activity of Crohn's disease through fecal calprotectin evaluated by balloon-assisted endoscopy. J. Gastroenterol. Hepatol.. 2018.06; ( PubMed , DOI )

  14. Wai-Kay Seto, Yasuhiro Asahina, Todd T Brown, Cheng-Yuan Peng, Carol Stanciu, Dzhamal Abdurakhmanov, Fehmi Tabak, Tuan T Nguyen, Wan-Long Chuang, Tetsuro Inokuma, Fusao Ikeda, Teresa Antonia Santantonio, François Habersetzer, Alnoor Ramji, Audrey H Lau, Vithika Suri, John F Flaherty, Hongyuan Wang, Anuj Gaggar, G Mani Subramanian, Shrikant Mukewar, Maurizia R Brunetto, Scott Fung, Henry Lik-Yuen Chan: Improved Bone Safety of Tenofovir Alafenamide Compared to Tenofovir Disoproxil Fumarate Over 2 Years in Patients With Chronic HBV Infection.[Epub ahead of print] Clin. Gastroenterol. Hepatol. 2018.06; ( PubMed , DOI )

  15. Maekawa Shinya, Sato Mitsuaki, Kuratomi Natsuhiko, Inoue Taisuke, Suzuki Yuichiro, Tatsumi Akihisa, Miura Mika, Matsuda Shuya, Muraoka Masaru, Nakakuki Natsuko, Amemiya Fumitake, Takano Shinichi, Fukasawa Mitsuharu, Nakayama Yasuhiro, Yamaguchi Tatsuya, Sato Tadashi, Sakamoto Minoru, Murakawa Miyako, Nakagawa Mina, Asahina Yasuhiro, Enomoto Nobuyuki: Association between alanine aminotransferase elevation and UGT1A1*6 polymorphisms in daclatasvir and asunaprevir combination therapy for chronic hepatitis C J. Gastroenterol. 2018.06; 53 (6): 780-786. ( ichushi )

  16. Yutaka Yasui, Kaoru Tsuchiya, Masayuki Kurosaki, Takaya Takeguchi, Yuko Takeguchi, Mao Okada, Wan Wang, Yohei Kubota, Tomoyuki Goto, Yasuyuki Komiyama, Mayu Higuchi, Kenta Takaura, Tsuguru Hayashi, Hitomi Takada, Nobuharu Tamaki, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Yasuhiro Asahina, Nobuyuki Enomoto, Yoshiro Himeno, Namiki Izumi: Up-to-seven criteria as a useful predictor for tumor downstaging to within Milan criteria and Child-Pugh grade deterioration after initial conventional transarterial chemoembolization. Hepatol. Res. 2018.05; 48 (6): 442-450. ( PubMed , DOI )

  17. M Kobayashi, S Ryozawa, K Nagata: Hepatobiliary and Pancreatic: A case of pure squamous cell carcinoma of the gallbladder. J. Gastroenterol. Hepatol.. 2018.05; 33 (5): 976. ( PubMed , DOI )

  18. Sasanuma S, Ohtsuka K, Kudo SE, Ogata N, Maeda Y, Misawa M, Mori Y, Kudo T, Hisayuki T, Wakamura K, Hayashi T, Katagiri A, Miyachi H, Baba T, Ishida F: Narrow band imaging efficiency in evaluation of mucosal healing/relapse of ulcerative colitis. Endoscopy international open. 2018.05; 6 (5): E518-E523. ( PubMed , DOI )

  19. Yoshiki Wada, Masayoshi Fukuda, Kazuo Ohtsuka, Mamoru Watanabe, Yumiko Fukuma, Yoko Wada, Masahiro Wada: Efficacy of Endocuff-assisted colonoscopy in the detection of colorectal polyps. Endosc Int Open. 2018.04; 6 (4): E425-E431. ( PubMed , DOI )

  20. Yuki Tanisaka, Shomei Ryozawa, Masanori Kobayashi, Maiko Harada, Tsutomu Kobatake, Kumiko Omiya, Hirotoshi Iwano, Shin Arai, Kouichi Nonaka, Yumi Mashimo: Usefulness of endoscopic ultrasound-guided fine needle aspiration for lymphadenopathy. Oncol Lett. 2018.04; 15 (4): 4759-4766. ( PubMed , DOI )

  21. Shintaro Akiyama, Masakazu Nagahori, Shinya Oooka, Mariko Negi, Takashi Ito, Kento Takenaka, Kazuo Ohtsuka, Mamoru Watanabe: Small intestinal obstruction due to the metastasis of intrahepatic cholangiocarcinoma: A case report. Medicine (Baltimore). 2018.03; 97 (12): e0190. ( PubMed , DOI )

  22. Hiroko Nagata, Mina Nakagawa, Yasuhiro Asahina: Reply to: "Imaging Basis of AFP and WFA+M2BP as Indicators of the risk of HCC after SVR". J. Hepatol. 2018.03; 68 (3): 607-608. ( PubMed , DOI )

  23. Ogata N, Ohtsuka K, Sasanuma S, Ogawa M, Maeda Y, Ichimasa K, Mori Y, Misawa M, Kudo T, Hisayuki T, Hayashi T, Wakamura K, Miyachi H, Baba T, Ishida F, Kudo SE: White light-emitting contrast image capsule endoscopy for visualization of small intestine lesions: a pilot study. Endoscopy international open. 2018.03; 6 (3): E315-E321. ( PubMed , DOI )

  24. Taro Watabe, Takashi Nagaishi, Naoya Tsugawa, Yudai Kojima, Nisha Jose, Akinori Hosoya, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Tetsuya Nakamura, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe: B cell activation in the cecal patches during the development of an experimental colitis model. Biochem. Biophys. Res. Commun.. 2018.02; 496 (2): 367-373. ( PubMed , DOI )

  25. Kento Takenaka, Kazuo Ohtsuka, Yoshio Kitazume, Katsuyoshi Matsuoka, Masakazu Nagahori, Toshimitsu Fujii, Eiko Saito, Maiko Kimura, Tomoyuki Fujioka, Mamoru Watanabe: Utility of Magnetic Resonance Enterography For Small Bowel Endoscopic Healing in Patients With Crohn's Disease Am. J. Gastroenterol. 2018.02; 113 (2): 283-294. ( PubMed , DOI )

  26. Yuki Tanisaka, Shomei Ryozawa, Masanori Kobayashi, Maiko Harada, Tsutomu Kobatake, Kumiko Omiya, Hirotoshi Iwano, Shin Arai, Kouichi Nonaka, Yumi Mashimo: Endoscopic removal of laser-cut covered self-expandable metallic biliary stents: A report of six cases. Mol Clin Oncol. 2018.02; 8 (2): 269-273. ( PubMed , DOI )

  27. Matsuda K, Tanaka K, Fujishiro M, Saito Y, Ohtsuka K, Oda I, Katada C, Kato M, Kida M, Kobayashi K, Hoteya S, Horimatsu T, Kodashima S, Matsuda T, Muto M, Yamamoto H, Ryozawa S, Iwakiri R, Kutsumi H, Miyata H, Kato M, Haruma K, Fujimoto K, Uemura N, Kaminishi M, Tajiri H: Design paper: Japan Endoscopy Database (JED): A prospective, large database project related to gastroenterological endoscopy in Japan. Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society. 2018.01; 30 (1): 5-19. ( PubMed , DOI )

  28. Kodashima S, Tanaka K, Matsuda K, Fujishiro M, Saito Y, Ohtsuka K, Oda I, Katada C, Kato M, Kida M, Kobayashi K, Hoteya S, Horimatsu T, Matsuda T, Muto M, Yamamoto H, Ryozawa S, Iwakiri R, Kutsumi H, Miyata H, Kato M, Haruma K, Fujimoto K, Uemura N, Kaminishi M, Tajiri H: First progress report on the Japan Endoscopy Database project. Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society. 2018.01; 30 (1): 20-28. ( PubMed , DOI )

  29. Shiro Yui, Luca Azzolin, Martti Maimets, Marianne Terndrup Pedersen, Robert P Fordham, Stine L Hansen, Hjalte L Larsen, Jordi Guiu, Mariana R P Alves, Carsten F Rundsten, Jens V Johansen, Yuan Li, Chris D Madsen, Tetsuya Nakamura, Mamoru Watanabe, Ole H Nielsen, Pawel J Schweiger, Stefano Piccolo, Kim B Jensen: YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration. Cell Stem Cell. 2018.01; 22 (1): 35-49.e7. ( PubMed , DOI )

  1. Taku Kobayashi, Asahi Hishida, Hiroki Tanaka, Yoichiro Nuki, Shigeki Bamba, Akihiro Yamada, Toshimitsu Fujii, Shinichiro Shinzaki, Yoko Yokoyama, Atsushi Yoshida, Keiji Ozeki, Shinya Ashizuka, Noriko Kamata, Sohachi Nanjo, Kazuki Kakimoto, Misaki Nakamura, Akira Matsui, Ryosuke Yamauchi, Sakuma Takahashi, Taku Tomizawa, Takuya Yoshino, Toshifumi Hibi: Real-world Experience of Anti-tumor Necrosis Factor Therapy for Internal Fistulas in Crohn's Disease: A Retrospective Multicenter Cohort Study. Inflamm. Bowel Dis.. 2017.12; 23 (12): 2245-2251. ( PubMed , DOI )

  2. Fumiaki Ishibashi, Hiromichi Shimizu, Toru Nakata, Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Sho Anzai, Reiko Kuno, Sayaka Nagata, Go Ito, Tatsuro Murano, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe, Ryuichi Okamoto: Contribution of ATOH1+ Cells to the Homeostasis, Repair, and Tumorigenesis of the Colonic Epithelium. [Epub ahead of print] Stem Cell Reports. 2017.12; ( PubMed , DOI )

  3. Yoichi Nibe, Shigeru Oshima, Masanori Kobayashi, Chiaki Maeyashiki, Yu Matsuzawa, Kana Otsubo, Hiroki Matsuda, Emi Aonuma, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Shinichiro Nakada, Mamoru Watanabe: Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by SQSTM1/p62. Autophagy. 2017.11; 14 (2): 1-43. ( PubMed , DOI )

  4. Masanori Kobayashi, Ou Yamaguchi, Koji Nagata, Kouichi Nonaka, Shomei Ryozawa: Acute hemorrhagic gastritis after nivolumab treatment. Gastrointest. Endosc.. 2017.11; 86 (5): 915-916. ( PubMed , DOI )

  5. Hiroko Nagata, Mina Nakagawa, Yasuhiro Asahina, Ayako Sato, Yu Asano, Tomoyuki Tsunoda, Masato Miyoshi, Shun Kaneko, Satoshi Otani, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Toshihiko Nouchi, Hideki Sakai, Makoto Tomita, Mamoru Watanabe: Effect of interferon-based and -free therapy on early occurrence and recurrence of hepatocellular carcinoma in chronic hepatitis C. J. Hepatol. 2017.11; 67 (5): 933-939. ( PubMed , DOI )

  6. Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K Naruse, Mamoru Watanabe, Akinori Kimura: MKL1 expressed in macrophages contributes to the development of murine colitis. Sci Rep. 2017.10; 7 (1): 13650. ( PubMed , DOI )

  7. Okabayashi S, Kobayashi T, Sujino T, Ozaki R, Umeda S, Toyonaga T, Saito E, Nakano M, Tablante MC, Morinaga S, Hibi T: Steroid-refractory extensive enteritis complicated by ulcerative colitis successfully treated with adalimumab. Intestinal research. 2017.10; 15 (4): 535-539. ( PubMed , DOI )

  8. Kaneko Shun, Kakinuma Sei, Asahina Yasuhiro, Kamiya Akihide, Miyoshi Masato, Tsunoda Tomoyuki, Inoue-Shinomiya Emi, Nitta Sayuri, Sato Ayako, Asano Yu, Nagata Hiroko, Kawai-Kitahata Fukiko, Murakawa Miyako, Itsui Yasuhiro, Nakagawa Mina, Azuma Seishin, Watanabe Mamoru: A novel culture model for coinfection of hepatitis B and hepatitis C viruses using human induced pluripotent stem cell-derived hepatic cells for analyses of changes in host-innate immune responses HEPATOLOGY. 2017.10; 66 69A.

  9. Nakagawa Mina, Asahina Yasuhiro, Nagata Hiroko, Kaneko Shun, Kawai-Kitahata Fukiko, Murakawa Miyako, Nitta Sayuri, Itsui Yasuhiro, Azuma Seishin, Kakinuma Sei, Tanaka Yujiro, Watanabe Mamoru: Evaluation of an early occurrence and recurrence of hepatocellular carcinoma in chronic hepatitis C patients treated with All-Oral DAAs - propensity score-matched analysis of a prospective database HEPATOLOGY. 2017.10; 66 38A-39A.

  10. Nitta Sayuri, Murakawa Miyako, Kato Takanobu, Sato Ayako, Tsunoda Tomoyuki, Miyoshi Masato, Asano Yu, Kaneko Shun, Nagata Hiroko, Kawai-Kitahata Fukiko, Itsui Yasuhiro, Nakagawa Mina, Azuma Seishin, Kakinuma Sei, Asahina Yasuhiro: The analysis of NS5A Resistance-Associated Substitutions (RAS): In vitro study of NS5A recombinant hepatitis C in infectious cell culture system for various RAS detected after treatment failure in chronic hepatitis C patients HEPATOLOGY. 2017.10; 66 480A.

  11. Murakawa Miyako, Asahina Yasuhiro, Nakagawa Mina, Nitta Sayuri, Kawai-Kitahata Fukiko, Nagata Hiroko, Kaneko Syun, Asano Yu, Miyoshi Masato, Tsunoda Tomoyuki, Inoue-Shinomiya Emi, Sato Ayako, Itsui Yasuhiro, Kakinuma Sei, Azuma Seishin, Watanabe Mamoru: On-treatment higher levels of alpha-fetoprotein and M2BPGi are associated with development of hepatocellular carcinoma during nucleos(t)ide analog therapy in patients with HBV chronic infection HEPATOLOGY. 2017.10; 66 507A.

  12. Murakawa Miyako, Asahina Yasuhiro, Nagata Hiroko, Nakagawa Mina, Kakinuma Sei, Nitta Sayuri, Kawai-Kitahata Fukiko, Otani Satoshi, Kaneko Shun, Miyoshi Masato, Tsunoda Tomoyuki, Asano Yu, Sato Ayako, Itsui Yasuhiro, Azuma Seishin, Nouchi Toshihiko, Furumoto Yohei, Asano Tooru, Chuganji Yoshimichi, Tohda Shuji, Watanabe Mamoru: ITPA gene variation and ribavirin-induced anemia in patients with genotype 2 chronic hepatitis C treated with sofosbuvir plus ribavirin Hepatology Research. 2017.10; 47 (11): 1212-1218. ( ichushi )

  13. Asahina Yasuhiro, Itoh Yoshito, Ueno Yoshiyuki, Matsuzaki Yasushi, Takikawa Yasuhiro, Yatsuhashi Hiroshi, Genda Takuya, Ikeda Fusao, Matsuda Takuma, Huang K. C., Massetto Benedetta, Osinusi Anu O., Brainard Diana M., McHutchison John G., Kawada Norifumi, Enomoto Nobuyuki: Ledipasvir/Sofosbuvir in the Treatment of Japanese Patients with Chronic HCV Genotype 2 Infection HEPATOLOGY. 2017.10; 66 638A.

  14. Tatsuro Yoneyama, Midori A Arai, Ryuta Akamine, Kazune Koryudzu, Anna Tsuchiya, Samir K Sadhu, Firoj Ahmed, Motoyuki Itoh, Ryuichi Okamoto, Masami Ishibashi: Notch Inhibitors from Calotropis gigantea That Induce Neuronal Differentiation of Neural Stem Cells. J. Nat. Prod. 2017.09; 80 (9): 2453-2461. ( PubMed , DOI )

  15. Azuma Seishin, Asahina Yasuhiro, Kakinuma Sei, Azuma Keiko, Watanabe Mamoru: Diabetic retinopathy as a risk factor associated with development of hepatocellular carcinoma in non-alcoholic fatty liver disease JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. 2017.09; 32 158.

  16. Jarno Drost, Ruben van Boxtel, Francis Blokzijl, Tomohiro Mizutani, Nobuo Sasaki, Valentina Sasselli, Joep de Ligt, Sam Behjati, Judith E Grolleman, Tom van Wezel, Serena Nik-Zainal, Roland P Kuiper, Edwin Cuppen, Hans Clevers: Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer Science. 2017.09; 358 (6360): 234-238. ( PubMed , DOI )

  17. Kento Takenaka, Kazuo Ohtsuka, Yoshio Kitazume, Katsuyoshi Matsuoka, Toshimitsu Fujii, Masakazu Nagahori, Maiko Kimura, Tomoyuki Fujioka, Akihiro Araki, Mamoru Watanabe: Magnetic resonance evaluation for small bowel strictures in Crohn's disease: comparison with balloon enteroscopy. J. Gastroenterol.. 2017.08; 52 (8): 879-888. ( PubMed , DOI )

  18. Tamaki N, Kurosaki M, Kusakabe A, Orito E, Joko K, Kojima Y, Kimura H, Uchida Y, Hasebe C, Asahina Y, Izumi N, Japanese Red Cross Hospital Liver Study Group.: Hepatitis B surface antigen reduction by switching from long-term nucleoside/nucleotide analogue administration to pegylated interferon. Journal of viral hepatitis. 2017.08; 24 (8): 672-678. ( PubMed , DOI )

  19. Goto Fumio, Kakinuma Sei, Miyoshi Masato, Tsunoda Tomoyuki, Kaneko Shun, Sato Ayako, Asano Yu, Otani Satoshi, Azuma Seishin, Nagata Hiroko, Kawai-Kitahata Fukiko, Murakawa Miyako, Nitta Sayuri, Itsui Yasuhiro, Nakagawa Mina, Asahina Yasuhiro, Watanabe Mamoru: Bone morphogenetic protein-4 modulates proliferation and terminal differentiation of fetal hepatic stem/progenitor cells Hepatology Research. 2017.08; 47 (9): 941-952. ( ichushi )

  20. Takenaka Kento, Ohtsuka Kazuo, Kitazume Yoshio, Matsuoka Katsuyoshi, Fujii Toshimitsu, Nagahori Masakazu, Kimura Maiko, Fujioka Tomoyuki, Araki Akihiro, Watanabe Mamoru: クローン病における小腸狭窄の磁気共鳴評価　バルーン小腸内視鏡検査との比較(Magnetic resonance evaluation for small bowel strictures in Crohn's disease: comparison with balloon enteroscopy) Journal of Gastroenterology. 2017.08; 52 (8): 879-888. ( ichushi )

  21. Yamamoto H, Ogata H, Matsumoto T, Ohmiya N, Ohtsuka K, Watanabe K, Yano T, Matsui T, Higuchi K, Nakamura T, Fujimoto K: Clinical Practice Guideline for Enteroscopy. Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society. 2017.07; 29 (5): 519-546. ( PubMed , DOI )

  22. Tomohiro Mizutani, Yoshiyuki Tsukamoto, Hans Clevers: Oncogene-inducible organoids as a miniature platform to assess cancer characteristics. J. Cell Biol. 2017.06; 216 (6): 1505-1507. ( PubMed , DOI )

  23. Shuji Hibiya, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Nobukatsu Horita, Sho Watanabe, Tomoaki Shirasaki, Ryu Nishimura, Natsuko Kimura, Tatsunori Nishimura, Noriko Gotoh, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe: Long-term Inflammation Transforms Intestinal Epithelial Cells of Colonic Organoids. J Crohns Colitis. 2017.05; 11 (5): 621-630. ( PubMed , DOI )

  24. Shintaro Akiyama, Toshimitsu Fujii, Katsuyoshi Matsuoka, Ebana Yusuke, Mariko Negi, Kento Takenaka, Masakazu Nagahori, Kazuo Ohtsuka, Mitsuaki Isobe, Mamoru Watanabe: Endoscopic features and genetic background of inflammatory bowel disease complicated with Takayasu arteritis. J. Gastroenterol. Hepatol.. 2017.05; 32 (5): 1011-1017. ( PubMed , DOI )

  25. Yasuharu Maeda, Kudo Shinei, Mori Yuichi, Misawa Masashi, Wakamura Kunihiko, Hayashi Seiko, Ogata Noriyuki, Takeda Kenichi, Kudo Toyoki, Hayashi Takemasa, Katagiri Atsushi, Ishida Fumio, Ohtsuka Kazuo, Oda Masahiro, Mori Kensaku: Artificial Intelligence for Endocytoscopy Provides Fully Automated Diagnosis of Histological Remission in Ulcerativ E. Coli Tis GASTROINTESTINAL ENDOSCOPY. 2017.05; 85 (5): AB248.

  26. Kentaro Matsuura, Hiromi Sawai, Kazuho Ikeo, Shintaro Ogawa, Etsuko Iio, Masanori Isogawa, Noritomo Shimada, Atsumasa Komori, Hidenori Toyoda, Takashi Kumada, Tadashi Namisaki, Hitoshi Yoshiji, Naoya Sakamoto, Mina Nakagawa, Yasuhiro Asahina, Masayuki Kurosaki, Namiki Izumi, Nobuyuki Enomoto, Atsunori Kusakabe, Eiji Kajiwara, Yoshito Itoh, Tatsuya Ide, Akihiro Tamori, Misako Matsubara, Norifumi Kawada, Ken Shirabe, Eiichi Tomita, Masao Honda, Shuichi Kaneko, Sohji Nishina, Atsushi Suetsugu, Yoichi Hiasa, Hisayoshi Watanabe, Takuya Genda, Isao Sakaida, Shuhei Nishiguchi, Koichi Takaguchi, Eiji Tanaka, Junichi Sugihara, Mitsuo Shimada, Yasuteru Kondo, Yosuke Kawai, Kaname Kojima, Masao Nagasaki, Katsushi Tokunaga, Yasuhito Tanaka, : Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection. Gastroenterology. 2017.05; 152 (6): 1383-1394. ( PubMed , DOI )

  27. Chiaki Maeyashiki, Shigeru Oshima, Kana Otsubo, Masanori Kobayashi, Yoichi Nibe, Yu Matsuzawa, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe: HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells. Biochem. Biophys. Res. Commun.. 2017.03; 484 (3): 636-641. ( PubMed , DOI )

  28. Toru Nakata, Hiromichi Shimizu, Sayaka Nagata, Go Ito, Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Reiko Kuno, Sho Anzai, Tatsuro Murano, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe, Ryuichi Okamoto: Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine. Data Brief. 2017.02; 10 551-556. ( PubMed , DOI )

  29. Endo Y., Ohtsuka K., Yoshida A., Ueno F., Takenaka K., Watanabe M.: A novel small-caliber deep enteroscope can overcome technical difficulty of insertion in patients with Crohn's disease JOURNAL OF CROHNS & COLITIS. 2017.02; 11 S164-S165.

  30. Nagata Sayaka, Fujii Satoru, Suzuki Kohei, Kawamoto Ami, Ishibashi Fumiaki, Nakata Toru, Anzai Sho, Kuno-Ishii Reiko, Ito Go, Shimizu Hiromichi, Tsuchiya Kiichiro, Nakamura Tetsuya, Ootsuka Kazuo, Okamoto Ryuichi, Watanabe Mamoru: PGE2 Is a Robust Mediator of Chloride and Water Secretion by Human Intestinal Epithelial Cells INFLAMMATORY BOWEL DISEASES. 2017.02; 23 S91-S92.

  31. Ozaki R., Kobayashi T., Saito E., Toyonaga T., Okabayashi S., Umeda S., Nakano M., Matsuoka K., Morinaga S., Hisamatsu T., Hibi T.: Histological risk factors to predict clinical relapse in ulcerative colitis in mucosal healing JOURNAL OF CROHNS & COLITIS. 2017.02; 11 S226.

  32. Matsuoka K., Iwamoto F., Kimura M., Takenaka K., Fujii T., Nagahori M., Enomoto N., Ohtsuka K., Watanabe M.: Correlation of fecal calprotectin levels with endoscopic severity evaluated with balloon-assisted endoscopy in patients with Crohn's disease JOURNAL OF CROHNS & COLITIS. 2017.02; 11 S208.

  33. Endo Y., Ohtsuka K., Yoshida A., Ueno F., Takenaka K., Watanabe M.: A novel small-caliber deep enteroscope can overcome technical difficulty of insertion in patients with Crohn's disease JOURNAL OF CROHNS & COLITIS. 2017.02; 11 S164-S165.

  34. Toru Nakata, Hiromichi Shimizu, Sayaka Nagata, Go Ito, Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Reiko Kuno, Sho Anzai, Tatsuro Murano, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe, Ryuichi Okamoto: Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors. Biochem. Biophys. Res. Commun.. 2017.01; 482 (4): 1296-1303. ( PubMed , DOI )

  35. Miyako Murakawa, Yasuhiro Asahina, Hiroko Nagata, Mina Nakagawa, Sei Kakinuma, Sayuri Nitta, Fukiko Kawai-Kitahata, Satoshi Otani, Shun Kaneko, Masato Miyoshi, Tomoyuki Tsunoda, Yu Asano, Ayako Sato, Yasuhiro Itsui, Seishin Azuma, Toshihiko Nouchi, Yohei Furumoto, Tooru Asano, Yoshimichi Chuganji, Shuji Tohda, Mamoru Watanabe: ITPA gene variation and ribavirin-induced anemia in patients with genotype 2 chronic hepatitis C treated with sofosbuvir plus ribavirin. Hepatol. Res.. 2017.01; ( PubMed , DOI )

  36. Toyonaga T, Kobayashi T, Nakano M, Saito E, Umeda S, Okabayashi S, Ozaki R, Hibi T: Usefulness of fecal calprotectin for the early prediction of short-term outcomes of remission-induction treatments in ulcerative colitis in comparison with two-item patient-reported outcome. PloS one. 2017; 12 (9): e0185131. ( PubMed , DOI )

  1. Toshiaki Watanabe, Yoichi Ajioka, Keiichi Mitsuyama, Kenji Watanabe, Hiroyuki Hanai, Hiroshi Nakase, Reiko Kunisaki, Keiji Matsuda, Ryuichi Iwakiri, Nobuyuki Hida, Shinji Tanaka, Yoshiaki Takeuchi, Kazuo Ohtsuka, Kazunari Murakami, Kiyonori Kobayashi, Yasushi Iwao, Masakazu Nagahori, Bunei Iizuka, Keisuke Hata, Masahiro Igarashi, Ichiro Hirata, Shin-Ei Kudo, Takayuki Matsumoto, Fumiaki Ueno, Gen Watanabe, Masahiro Ikegami, Yoko Ito, Koji Oba, Eisuke Inoue, Naoki Tomotsugu, Toru Takebayashi, Kenichi Sugihara, Yasuo Suzuki, Mamoru Watanabe, Toshifumi Hibi: Comparison of Targeted vs Random Biopsies for Surveillance of Ulcerative Colitis-Associated Colorectal Cancer. Gastroenterology. 2016.12; 151 (6): 1122-1130. ( PubMed , DOI )

  2. Miyako Murakawa, Yasuhiro Asahina, Fukiko Kawai-Kitahata, Mina Nakagawa, Sayuri Nitta, Satoshi Otani, Hiroko Nagata, Shun Kaneko, Yu Asano, Tomoyuki Tsunoda, Masato Miyoshi, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Yasuhito Tanaka, Sayuki Iijima, Kaoru Tsuchiya, Namiki Izumi, Shuji Tohda, Mamoru Watanabe: Hepatic IFNL4 expression is associated with non-response to interferon-based therapy through the regulation of basal interferon-stimulated gene expression in chronic hepatitis C patients. [Epub ahead of print] J. Med. Virol.. 2016.12; ( PubMed , DOI )

  3. Ryuichi Okamoto, Mamoru Watanabe: Functional relevance of intestinal epithelial cells in inflammatory bowel disease. Nihon Rinsho Meneki Gakkai Kaishi. 2016.11; 39 (6): 522-527. ( PubMed , DOI )

  4. Hitomi Takada, Kaoru Tsuchiya, Yutaka Yasui, Natsuko Nakakuki, Nobuharu Tamaki, Shoko Suzuki, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Masayuki Kurosaki, Yasuhiro Asahina, Nobuyuki Enomoto, Namiki Izumi: Irregular vascular pattern by contrast-enhanced ultrasonography and high serum Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein level predict poor outcome after successful radiofrequency ablation in patients with early-stage hepatocellular carcinoma. Cancer Med. 2016.11; 5 (11): 3111-3120. ( PubMed , DOI )

  5. Masanori Kobayashi, Shigeru Oshima, Chiaki Maeyashiki, Yoichi Nibe, Kana Otsubo, Yu Matsuzawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe: The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development. Sci Rep. 2016.11; 6 36780. ( PubMed , DOI )

  6. Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Toru Nakata, Tatsuro Murano, Go Ito, Hiromichi Shimizu, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Akihiro Araki, Kazuo Ohtsuka, Ryuichi Okamoto, Mamoru Watanabe: PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells. Sci Rep. 2016.11; 6 36795. ( PubMed , DOI )

  7. Sayuri Nitta, Yasuhiro Asahina, Mami Matsuda, Norie Yamada, Ryuichi Sugiyama, Takahiro Masaki, Ryosuke Suzuki, Nobuyuki Kato, Mamoru Watanabe, Takaji Wakita, Takanobu Kato: Effects of Resistance-Associated NS5A Mutations in Hepatitis C Virus on Viral Production and Susceptibility to Antiviral Reagents. Sci Rep. 2016.10; 6 34652. ( PubMed , DOI )

  8. Masato Miyoshi, Sei Kakinuma, Yoko Tanabe, Koji Ishii, Tian-Cheng Li, Takaji Wakita, Yukio Tsuura, Hideki Watanabe, Yasuhiro Asahina, Mamoru Watanabe, Takaaki Ikeda: Chronic Hepatitis E Infection in a Persistently Immunosuppressed Patient Unable to Be Eliminated after Ribavirin Therapy. Intern. Med. 2016.10; 55 (19): 2811-2817. ( PubMed , DOI )

  9. Miyoshi Masato, Kakinuma Sei, Tanabe Yoko, Ishii Koji, Li Tian-Cheng, Wakita Takaji, Tsuura Yukio, Watanabe Hideki, Asahina Yasuhiro, Watanabe Mamoru, Ikeda Takaaki: 恒常的免疫抑制患者における慢性E型肝炎感染はリバビリン療法後に排除することができない(Chronic Hepatitis E Infection in a Persistently Immunosuppressed Patient Unable to Be Eliminated after Ribavirin Therapy) Internal Medicine. 2016.10; 55 (19): 2811-2817. ( ichushi )

  10. Jun Itakura, Masayuki Kurosaki, Chitomi Hasebe, Yukio Osaki, Kouji Joko, Hitoshi Yagisawa, Shinya Sakita, Hiroaki Okushin, Takashi Satou, Hiroyuki Hisai, Takehiko Abe, Keiji Tsuji, Takashi Tamada, Haruhiko Kobashi, Akeri Mitsuda, Yasushi Ide, Chikara Ogawa, Syotaro Tsuruta, Kouichi Takaguchi, Miyako Murakawa, Yasuhiro Asahina, Nobuyuki Enomoto, Namiki Izumi: Complex Pattern of Resistance-Associated Substitutions of Hepatitis C Virus after Daclatasvir/Asunaprevir Treatment Failure. PLoS ONE. 2016.10; 11 (10): e0165339. ( PubMed , DOI )

  11. Fumio Goto, Sei Kakinuma, Masato Miyoshi, Tomoyuki Tsunoda, Shun Kaneko, Ayako Sato, Yu Asano, Satoshi Otani, Seishin Azuma, Hiroko Nagata, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Mina Nakagawa, Yasuhiro Asahina, Mamoru Watanabe: Bone morphogenetic protein-4 modulates proliferation and terminal differentiation of fetal hepatic stem/progenitor cells. Hepatol. Res. 2016.09; 47 (9): 941-952. ( PubMed , DOI )

  12. Naoki Hosoe, Kenji Watanabe, Takako Miyazaki, Masaaki Shimatani, Takahiro Wakamatsu, Kazuichi Okazaki, Motohiro Esaki, Takayuki Matsumoto, Takayuki Abe, Takanori Kanai, Kazuo Ohtsuka, Mamoru Watanabe, Keiichi Ikeda, Hisao Tajiri, Naoki Ohmiya, Masanao Nakamura, Hidemi Goto, Tomoyuki Tsujikawa, Haruhiko Ogata: Evaluation of performance of the Omni mode for detecting video capsule endoscopy images: A multicenter randomized controlled trial. Endosc Int Open. 2016.08; 4 (8): E878-E882. ( PubMed , DOI )

  13. Ryuichi Okamoto, Mariko Negi, Syohei Tomii, Yoshinobu Eishi, Mamoru Watanabe: Diagnosis and treatment of microscopic colitis. Clin J Gastroenterol. 2016.08; 9 (4): 169-174. ( PubMed , DOI )

  14. Taichi Matsumoto, Wakana Mochizuki, Yoichi Nibe, Shintaro Akiyama, Yuka Matsumoto, Kengo Nozaki, Masayoshi Fukuda, Ayumi Hayashi, Tomohiro Mizutani, Shigeru Oshima, Mamoru Watanabe, Tetsuya Nakamura: Retinol Promotes In Vitro Growth of Proximal Colon Organoids through a Retinoic Acid-Independent Mechanism. PLoS ONE. 2016.08; 11 (8): e0162049. ( PubMed , DOI )

  15. Hiroko Nagata, Mina Nakagawa, Yuki Nishimura-Sakurai, Yu Asano, Tomoyuki Tsunoda, Masato Miyoshi, Shun Kaneko, Fumio Goto, Satoshi Otani, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Naoko Tojo, Shuji Tohda, Yasuhiro Asahina, Mamoru Watanabe, : Serial measurement of Wisteria floribunda agglutinin positive Mac-2-binding protein is useful for predicting liver fibrosis and the development of hepatocellular carcinoma in chronic hepatitis C patients treated with IFN-based and IFN-free therapy.[Epub ahead of print] Hepatol Int. 2016.07; ( PubMed , DOI )

  16. Shun Kaneko, Sei Kakinuma, Yasuhiro Asahina, Akihide Kamiya, Masato Miyoshi, Tomoyuki Tsunoda, Sayuri Nitta, Yu Asano, Hiroko Nagata, Satoshi Otani, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Hiromitsu Nakauchi, Hironori Nishitsuji, Saneyuki Ujino, Kunitada Shimotohno, Masashi Iwamoto, Koichi Watashi, Takaji Wakita, Mamoru Watanabe: Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus. Sci Rep. 2016.07; 6 29358. ( PubMed , DOI )

  17. Ryohei Hayashi, Kiichiro Tsuchiya, Keita Fukushima, Nobukatsu Horita, Shuji Hibiya, Keisuke Kitagaki, Mariko Negi, Eisaku Itoh, Takumi Akashi, Yoshinobu Eishi, Eriko Okada, Akihiro Araki, Kazuo Ohtsuka, Shinji Fukuda, Hiroshi Ohno, Ryuichi Okamoto, Tetsuya Nakamura, Shinji Tanaka, Kazuaki Chayama, Mamoru Watanabe: Reduced Human α-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease. Inflamm. Bowel Dis. 2016.05; 22 (5): 1119-1128. ( PubMed , DOI )

  18. Kawai-Kitahata F, Asahina Y, Tanaka S, Kakinuma S, Murakawa M, Nitta S, Watanabe T, Otani S, Taniguchi M, Goto F, Nagata H, Kaneko S, Tasaka-Fujita M, Nishimura-Sakurai Y, Azuma S, Itsui Y, Nakagawa M, Tanabe M, Takano S, Fukasawa M, Sakamoto M, Maekawa S, Enomoto N, Watanabe M: Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features 2016.05;

  19. Ryuichi Okamoto, Mamoru Watanabe: Investigating cell therapy for inflammatory bowel disease. Expert Opin Biol Ther. 2016.04; 1-9. ( PubMed , DOI )

  20. Seishin Azuma, Yasuhiro Asahina, Yuki Nishimura-Sakurai, Sei Kakinuma, Shun Kaneko, Hiroko Nagata, Fumio Goto, Satoshi Ootani, Fukiko Kawai-Kitahata, Miki Taniguchi, Miyako Murakawa, Takako Watanabe, Megumi Tasaka-Fujita, Yasuhiro Itsui, Mina Nakagawa, Mamoru Watanabe: Efficacy of additional radiofrequency ablation after transcatheter arterial chemoembolization for intermediate hepatocellular carcinoma. Hepatol. Res.. 2016.04; 46 (4): 312-319. ( PubMed , DOI )

  21. Kazuo Ohtsuka, Kento Takenaka, Yoshio Kitazume, Toshimitsu Fujii, Katsuyoshi Matsuoka, Maiko Kimura, Takashi Nagaishi, Mamoru Watanabe: Magnetic resonance enterography for the evaluation of the deep small intestine in Crohn's disease. Intest Res. 2016.04; 14 (2): 120-126. ( PubMed , DOI )

  22. Miki Taniguchi, Megumi Tasaka-Fujita, Mina Nakagawa, Takako Watanabe, Fukiko Kawai-Kitahata, Satoshi Otani, Fumio Goto, Hiroko Nagata, Shun Kaneko, Sayuri Nitta, Miyako Murakawa, Yuki Nishimura-Sakurai, Seishin Azuma, Yasuhiro Itsui, Kenichi Mori, Shintaro Yagi, Sei Kakinuma, Yasuhiro Asahina, Mamoru Watanabe: Evaluation of Interferon Resistance in Newly Established Genotype 1b Hepatitis C Virus Cell Culture System. J Clin Transl Hepatol. 2016.03; 4 (1): 5-11. ( PubMed , DOI )

  23. Kengo Nozaki, Wakana Mochizuki, Yuka Matsumoto, Taichi Matsumoto, Masayoshi Fukuda, Tomohiro Mizutani, Mamoru Watanabe, Tetsuya Nakamura: Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes. J. Gastroenterol. 2016.03; 51 (3): 206-213. ( PubMed , DOI )

  24. Yasuhiro Asahina, Namiki Izumi, Kumada Hiromitsu, Masayuki Kurosaki, Kazuhiko Koike, Fumitaka Suzuki, Hajime Takikawa, Atsushi Tanaka, Eiji Tanaka, Yasuhito Tanaka, Hirohito Tsubouchi, Norio Hayashi, Naoki Hiramatsu, Hiroshi Yotsuyanagi: JSH Guidelines for the Management of Hepatitis C Virus Infection: A 2016 update for genotype 1 and 2. Hepatol. Res. 2016.02; 46 (2): 129-165. ( PubMed , DOI )

  25. Satoshi Otani, Sei Kakinuma, Akihide Kamiya, Fumio Goto, Shun Kaneko, Masato Miyoshi, Tomoyuki Tsunoda, Yu Asano, Fukiko Kawai-Kitahata, Sayuri Nitta, Toru Nakata, Ryuichi Okamoto, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Yasuhiro Asahina, Tomoyuki Yamaguchi, Naohiko Koshikawa, Motoharu Seiki, Hiromitsu Nakauchi, Mamoru Watanabe: Matrix metalloproteinase-14 mediates formation of bile ducts and hepatic maturation of fetal hepatic progenitor cells. Biochem. Biophys. Res. Commun.. 2016.01; 469 (4): 1062-1068. ( PubMed , DOI )

  26. Takashi Nagaishi, Taro Watabe, Nisha Jose, Arisa Tokai, Toshimitsu Fujii, Katsuyoshi Matsuoka, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe: Epithelial Nuclear Factor-κB Activation in Inflammatory Bowel Diseases and Colitis-Associated Carcinogenesis. Digestion. 2016.01; 93 (1): 40-46. ( PubMed , DOI )

  27. Yasuhiro Asahina, Mamoru Watanabe: Need for appropriate programs for prevention of hepatitis B infection: Lessons from the latest nationwide survey in Japan. J. Gastroenterol. Hepatol. 2016.01; 31 (1): 12-13. ( PubMed , DOI )

  28. Ryuichi Okamoto, Mamoru Watanabe: Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease. J. Gastroenterol. 2016.01; 51 (1): 11-21. ( PubMed , DOI )

  1. Fukiko Kawai-Kitahata, Yasuhiro Asahina, Shinji Tanaka, Sei Kakinuma, Miyako Murakawa, Sayuri Nitta, Takako Watanabe, Satoshi Otani, Miki Taniguchi, Fumio Goto, Hiroko Nagata, Shun Kaneko, Megumi Tasaka-Fujita, Yuki Nishimura-Sakurai, Seishin Azuma, Yasuhiro Itsui, Mina Nakagawa, Minoru Tanabe, Shinichi Takano, Mitsuharu Fukasawa, Minoru Sakamoto, Shinya Maekawa, Nobuyuki Enomoto, Mamoru Watanabe: Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features. J. Gastroenterol. 2015.11; ( PubMed , DOI )

  2. Megumi Tasaka-Fujita, Nao Sugiyama, Wonseok Kang, Takahiro Masaski, Asako Murayama, Norie Yamada, Ryuichi Sugiyama, Senko Tsukuda, Koichi Watashi, Yasuhiro Asahina, Naoya Sakamoto, Takaji Wakita, Eui-Cheol Shin, Takanobu Kato: Amino acid polymorphisms in hepatitis C virus core affect infectious virus production and major histocompatibility complex class I molecule expression. Sci Rep. 2015.09; 5 13994. ( PubMed , DOI )

  3. Nobuharu Tamaki, Masayuki Kurosaki, Mayu Higuchi, Hitomi Takada, Natsuko Nakakuki, Yutaka Yasui, Shoko Suzuki, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Shintaro Ogawa, Yasuhito Tanaka, Yasuhiro Asahina, Namiki Izumi: Genetic polymorphisms of IL28B and PNPLA3 are predictive for HCV related rapid fibrosis progression and identify patients who require urgent antiviral treatment with new regimens. PLoS ONE. 2015.09; 10 (9): e0137351. ( PubMed , DOI )

  4. Kento Takenaka, Kazuo Ohtsuka, Yoshio Kitazume, Masakazu Nagahori, Toshimitsu Fujii, Eiko Saito, Tomoyuki Fujioka, Katsuyoshi Matsuoka, Makoto Naganuma, Mamoru Watanabe: Correlation of the Endoscopic and Magnetic Resonance Scoring Systems in the Deep Small Intestine in Crohn's Disease. Inflamm. Bowel Dis.. 2015.08; 21 (8): 1832-1838. ( PubMed , DOI )

  5. Ryuichi Okamoto, Mamoru Watanabe: Perspectives for Regenerative Medicine in the Treatment of Inflammatory Bowel Diseases. Digestion. 2015.07; 92 (2): 73-77. ( PubMed , DOI )

  6. Yu Matsuzawa, Shigeru Oshima, Masahiro Takahara, Chiaki Maeyashiki, Yasuhiro Nemoto, Masanori Kobayashi, Yoichi Nibe, Kengo Nozaki, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Averil Ma, Mamoru Watanabe: TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy. Autophagy. 2015.06; 11 (7): 1052-1062. ( PubMed , DOI )

  7. Miyako Murakawa, Yasuhiro Asahina, Mina Nakagawa, Naoya Sakamoto, Sayuri Nitta, Akiko Kusano-Kitazume, Takako Watanabe, Fukiko Kawai-Kitahata, Satoshi Otani, Miki Taniguchi, Fumio Goto, Yuki Nishimura-Sakurai, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Mamoru Watanabe: Impaired induction of interleukin 28B and expression of interferon λ 4 associated with nonresponse to interferon-based therapy in chronic hepatitis C. J. Gastroenterol. Hepatol. 2015.06; 30 (6): 1075-1084. ( PubMed , DOI )

  8. Keita Fukushima, Kiichiro Tsuchiya, Yoshihito Kano, Nobukatsu Horita, Shuji Hibiya, Ryohei Hayashi, Keisuke Kitagaki, Mariko Negi, Eisaku Itoh, Takumi Akashi, Yoshinobu Eishi, Shigeru Oshima, Takashi Nagaishi, Okamoto Ryuichi, Tetsuya Nakamura, Mamoru Watanabe: Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line. Cancer Sci.. 2015.05; ( PubMed , DOI )

  9. Ulrike W Denzer, Thomas Rösch, Bilal Hoytat, Mohammed Abdel-Hamid, Xavier Hebuterne, Geoffroy Vanbiervielt, Jérôme Filippi, Haruiko Ogata, Naoki Hosoe, Kazuo Ohtsuka, Noriyuki Ogata, Keiichi Ikeda, Hiroyuki Aihara, Shin-Ei Kudo, Hisao Tajiri, Andras Treszl, Karl Wegscheider, Michel Greff, Jean-Francois Rey: Magnetically guided capsule versus conventional gastroscopy for upper abdominal complaints: a prospective blinded study. J. Clin. Gastroenterol.. 2015.02; 49 (2): 101-107. ( PubMed , DOI )

  10. Yasuharu Maeda, Kazuo Ohtsuka, Shin-ei Kudo, Kunihiko Wakamura, Yuichi Mori, Noriyuki Ogata, Yoshiki Wada, Masashi Misawa, Akihiro Yamauchi, Seiko Hayashi, Toyoki Kudo, Takemasa Hayashi, Hideyuki Miyachi, Fuyuhiko Yamamura, Fumio Ishida, Haruhiro Inoue, Shigeharu Hamatani: Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis. World J. Gastroenterol.. 2015.02; 21 (7): 2108-2115. ( PubMed , DOI )

  11. Yu Matsuzawa, Shigeru Oshima, Yoichi Nibe, Masanori Kobayashi, Chiaki Maeyashiki, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe: RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62. Biochem. Biophys. Res. Commun.. 2015.01; 456 (1): 298-304. ( PubMed , DOI )

  1. Nobutoshi Komatsu, Utaroh Motosugi, Shinya Maekawa, Kuniaki Shindo, Minoru Sakamoto, Mitsuaki Sato, Akihisa Tatsumi, Mika Miura, Fumitake Amemiya, Yasuhiro Nakayama, Taisuke Inoue, Mitsuharu Fukasawa, Tomoyoshi Uetake, Masahiko Ohtaka, Tadashi Sato, Yasuhiro Asahina, Masayuki Kurosaki, Namiki Izumi, Tomoaki Ichikawa, Tsutomu Araki, Nobuyuki Enomoto: Hepatocellular carcinoma risk assessment using gadoxetic acid-enhanced hepatocyte phase magnetic resonance imaging. Hepatol Res. 2014.12; 44 (13): 1339-1346. ( PubMed , DOI )

  2. Nobuharu Tamaki, Masayuki Kurosaki, Shuya Matsuda, Masaru Muraoka, Yutaka Yasui, Shoko Suzuki, Takanori Hosokawa, Ken Ueda, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Yasuhiro Asahina, Namiki Izumi: Non-invasive prediction of hepatocellular carcinoma development using serum fibrosis marker in chronic hepatitis C patients. J. Gastroenterol. 2014.11; 49 (11): 1495-1503. ( PubMed , DOI )

  3. Xuan Li, Yun-Jia Zhao, Jun Dai, Xiao-Bo Li, Han-Bin Xue, Yao Zhang, Guang-Su Xiong, Kazuo Ohtsuka, Yun-Jie Gao, Qiang Liu, Yan Song, Jing-Yuan Fang, Zhi-Zheng Ge: Carbon dioxide insufflation improves the intubation depth and total enteroscopy rate in single-balloon enteroscopy: a randomised, controlled, double-blind trial. Gut. 2014.10; 63 (10): 1560-1565. ( PubMed , DOI )

  4. Nobukatsu Horita, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Shuji Hibiya, Masayoshi Fukuda, Yoshihito Kano, Tomohiro Mizutani, Yasuhiro Nemoto, Shiro Yui, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe: Fluorescent labelling of intestinal epithelial cells reveals independent long-lived intestinal stem cells in a crypt. Biochem. Biophys. Res. Commun. 2014.10; 454 (4): 493-499. ( PubMed , DOI )

  5. Yoshihito Kano, Sei Kakinuma, Fumio Goto, Seishin Azuma, Yuki Nishimura-Sakurai, Yasuhiro Itsui , Mina Nakagawa, Atsushi Kudo, Minoru Tanabe, Susumu Kirimura, Tomonori Amano, Takashi Ito , Takumi Akashi, Yasuhiro Asahina, Mamoru Watanabe: Primary Hepatic Neuroendocrine Carcinoma with a Cholangiocellular Carcinoma Component in One Nodule. Clinical Journal of Gastroenterology. 2014.10; 7 449-454.

  6. Yoshihito Kano, Sei Kakinuma, Fumio Goto, Seishin Azuma, Yuki Nishimura-Sakurai, Yasuhiro Itsui, Mina Nakagawa, Atsushi Kudo, Minoru Tanabe, Susumu Kirimura, Tomonori Amano, Takashi Ito, Takumi Akashi, Yasuhiro Asahina, Mamoru Watanabe: Primary hepatic neuroendocrine carcinoma with a cholangiocellular carcinoma component in one nodule. Clin J Gastroenterol. 2014.10; 7 (5): 449-454. ( PubMed , DOI )

  7. Goki Suda, Yoshiya Yamamoto, Astushi Nagasaka, Ken Furuya, Mineo Kudo, Yoshimichi Chuganji, Yoko Tsukuda, Seiji Tsunematsu, Fumiyuki Sato, Katsumi Terasita, Masato Nakai, Hiromasa Horimoto, Takuya Sho, Mitsuteru Natsuizaka, Kouji Ogawa, Shunsuke Ohnishi, Makoto Chuma, Yasuyuki Fujita, Riichiro Abe, Miki Taniguchi, Mina Nakagawa, Yasuhiro Asahina, Naoya Sakamoto, : Serum granulysin levels as a predictor of serious telaprevir-induced dermatological reactions. Hepatol Res.. 2014.09; ( PubMed , DOI )

  8. Kaoru Tsuchiya, Yasuhiro Asahina, Masayuki Kurosaki, Nobuyuki Enomoto, Namiki Izumi: Reply: To PMID 24734314. Liver Transpl. 2014.09; 20 (9): 1152. ( PubMed , DOI )

  9. Yasuhiro Asahina, Kaoru Tsuchiya, Namiki Izumi: Reply: To PMID 23564522. Hepatology. 2014.08; 60 (2): 764. ( PubMed , DOI )

  10. Yasuhiro Iizuka, Hideki Sakai, Konomi Kobayashi, Kazue Iizuka, Eri Ito, Nahoko Mochizuki, Yasuhiro Asahina, Mamoru Watanabe: A case of chronic hepatitis B managed with continued adefovir despite treatment-related Fanconi syndrome and osteomalacia. Nihon Shokakibyo Gakkai Zasshi. 2014.08; 111 (8): 1618-1623. ( PubMed )

  11. Masayoshi Fukuda, Tomohiro Mizutani, Wakana Mochizuki, Taichi Matsumoto, Kengo Nozaki, Yuriko Sakamaki, Shizuko Ichinose, Yukinori Okada, Toshihiro Tanaka, Mamoru Watanabe, Tetsuya Nakamura: Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon. Genes Dev. 2014.08; 28 (16): 1752-1757. ( PubMed , DOI )

  12. Kento Takenaka, Kazuo Ohtsuka, Yoshio Kitazume, Masakazu Nagahori, Toshimitsu Fujii, Eiko Saito, Makoto Naganuma, Akihiro Araki, Mamoru Watanabe: Comparison of magnetic resonance and balloon enteroscopic examination of the small intestine in patients with Crohn's disease. Gastroenterology. 2014.08; 147 (2): 334-342.e3. ( PubMed )

  13. Nobuharu Tamaki, Masayuki Kurosaki, Shuya Matsuda, Toru Nakata, Masaru Muraoka, Yuichiro Suzuki, Yutaka Yasui, Shoko Suzuki, Takanori Hosokawa, Takashi Nishimura, Ken Ueda, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Kotaro Matsunaga, Kazuhiro Taki, Yasuhiro Asahina, Namiki Izumi: Prospective comparison of real-time tissue elastography and serum fibrosis markers for the estimation of liver fibrosis in chronic hepatitis C patients. Hepatol Res. 2014.07; 44 (7): 720-727. ( PubMed , DOI )

  14. Yasuhiro Asahina, Kaoru Tsuchiya, Takashi Nishimura, Masaru Muraoka, Yuichiro Suzuki, Nobuharu Tamaki, Yutaka Yasui, Takanori Hosokawa, Ken Ueda, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Masayuki Kurosaki, Nobuyuki Enomoto, Mina Nakagawa, Sei Kakinuma, Mamoru Watanabe, Namiki Izumi: Genetic variation near interleukin 28B and the risk of hepatocellular carcinoma in patients with chronic hepatitis C. J. Gastroenterol. 2014.07; 49 (7): 1152-1162. ( PubMed , DOI )

  15. Hiromichi Shimizu, Ryuichi Okamoto, Go Ito, Satoru Fujii, Toru Nakata, Kohei Suzuki, Tatsuro Murano, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe: Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine. PeerJ. 2014.05; 2 (1): e370. ( PubMed , DOI )

  16. Hiroyuki Nakanishi, Masayuki Kurosaki, Kaoru Nakanishi, Kaoru Tsuchiya, Takamasa Noda, Nobuharu Tamaki, Yutaka Yasui, Takanori Hosokawa, Ken Ueda, Jun Itakura, Kimitaka Anami, Yasuhiro Asahina, Nobuyuki Enomoto, Teruhiko Higuchi, Namiki Izumi: Impaired brain activity in cirrhotic patients with minimal hepatic encephalopathy: Evaluation by near-infrared spectroscopy. Hepatol Res. 2014.03; 44 (3): 319-326. ( PubMed , DOI )

  17. Kaoru Tsuchiya, Yasuhiro Asahina, Nobuharu Tamaki, Yutaka Yasui, Takanori Hosokawa, Ken Ueda, Hiroyuki Nakanishi, Jun Itakura, Masayuki Kurosaki, Nobuyuki Enomoto, Namiki Izumi: Risk factors for exceeding the Milan criteria after successful radiofrequency ablation in patients with early-stage hepatocellular carcinoma. Liver Transpl. 2014.03; 20 (3): 291-297. ( PubMed )

  18. Masanori Kobayashi, Akahito Sako, Toshiko Ogami, So Nishimura, Naoki Asayama, Tomoyuki Yada, Naoyoshi Nagata, Toshiyuki Sakurai, Chizu Yokoi, Masao Kobayakawa, Mikio Yanase, Naohiko Masaki, Nozomi Takeshita, Naomi Uemura: Validation of the 3-day rule for stool bacterial tests in Japan. Intern. Med.. 2014.03; 53 (6): 533-539. ( PubMed )

  19. Masahiro Suzuki, Takashi Nagaishi, Motomi Yamazaki, Michio Onizawa, Taro Watabe, Yuriko Sakamaki, Shizuko Ichinose, Mamoru Totsuka, Shigeru Oshima, Ryuichi Okamoto, Motoyuki Shimonaka, Hideo Yagita, Tetsuya Nakamura, Mamoru Watanabe: Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis. PLoS ONE. 2014.02; 9 (2): e88369. ( PubMed , DOI )

  20. Nao Nishida, Hiromi Sawai, Koichi Kashiwase, Mutsuhiko Minami, Masaya Sugiyama, Wai-Kay Seto, Man-Fung Yuen, Nawarat Posuwan, Yong Poovorawan, Sang Hoon Ahn, Kwang-Hyub Han, Kentaro Matsuura, Yasuhito Tanaka, Masayuki Kurosaki, Yasuhiro Asahina, Namiki Izumi, Jong-Hon Kang, Shuhei Hige, Tatsuya Ide, Kazuhide Yamamoto, Isao Sakaida, Yoshikazu Murawaki, Yoshito Itoh, Akihiro Tamori, Etsuro Orito, Yoichi Hiasa, Masao Honda, Shuichi Kaneko, Eiji Mita, Kazuyuki Suzuki, Keisuke Hino, Eiji Tanaka, Satoshi Mochida, Masaaki Watanabe, Yuichiro Eguchi, Naohiko Masaki, Kazumoto Murata, Masaaki Korenaga, Yoriko Mawatari, Jun Ohashi, Minae Kawashima, Katsushi Tokunaga, Masashi Mizokami: New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia. PLoS ONE. 2014.02; 9 (2): e86449. ( PubMed , DOI )

  21. Asahina Y, HayashinN, Hiramatsu N, Izumi N, Koike K, Kumada H, Kurosaki M,Oketani M, Suzuki F, Takikawa H, Tanaka A, Tanaka E, Tanaka Y, Tsubouchi H,Yotsuyanagi H: JSH Guidelines for the Management of Hepatitis B Virus Infection. Hepatol Res. 2014.01; 44 Suppl S1 1-58. ( PubMed , DOI )

  22. Eiko Saito, Masakazu Nagahori, Toshimitsu Fujii, Kazuo Ohtsuka, Mamoru Watanabe: Efficacy of salvage therapy and its effect on operative outcomes in patients with ulcerative colitis. Digestion. 2014.01; 89 (1): 55-60. ( PubMed , DOI )

  23. Toshimitsu Fujii, Makoto Naganuma, Yoshio Kitazume, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe: Advancing magnetic resonance imaging in Crohn's disease. Digestion. 2014.01; 89 (1): 24-30. ( PubMed , DOI )

  24. Kaoru Tsuchiya, Yasuhiro Asahina, Shuya Matsuda, Masaru Muraoka, Toru Nakata, Yuichiro Suzuki, Nobuharu Tamaki, Yutaka Yasui, Shoko Suzuki, Takanori Hosokawa, Takashi Nishimura, Ken Ueda, Teiji Kuzuya, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Masayuki Kurosaki, Nobuyuki Enomoto, Namiki Izumi: Changes in plasma vascular endothelial growth factor at 8 weeks after sorafenib administration as predictors of survival for advanced hepatocellular carcinoma. Cancer. 2014.01; 120 (2): 229-237. ( PubMed , DOI )

  25. Tatsuro Murano, Ryuichi Okamoto, Go Ito, Toru Nakata, Shuji Hibiya, Hiromichi Shimizu, Satoru Fujii, Yoshihito Kano, Tomohiro Mizutani, Shiro Yui, Junko Akiyama-Morio, Yasuhiro Nemoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe: Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells. Biochem. Biophys. Res. Commun. 2014.01; 443 (3): 840-846. ( PubMed , DOI )

  26. Yasui Y, Kudo A, Kurosaki M, Matsuda S, Muraoka M, Tamaki N, Suzuki S, Hosokawa T, Ueda K, Matsunaga K, Nakanishi H, Tsuchiya K, Itakura J, Takahashi Y, Tanaka S, Asahina Y, Enomoto N, Arii S, Izumi N.: Reduced organic anion transporter expression is a risk factor for hepatocellular carcinoma in chronic hepatitis C patients: a propensity score matching study. Oncology. 2014.01; 86 (1): 53-62. ( PubMed , DOI )

  1. Robert P Fordham, Shiro Yui, Nicholas R F Hannan, Christoffer Soendergaard, Alison Madgwick, Pawel J Schweiger, Ole H Nielsen, Ludovic Vallier, Roger A Pedersen, Tetsuya Nakamura, Mamoru Watanabe, Kim B Jensen: Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury. Cell Stem Cell. 2013.12; 13 (6): 734-744. ( PubMed , DOI )

  2. Okamoto R, Nagaori T, Watanabe M: Prespectives for IBD in Japan. AGA Perspectives. 2013.12; 9 (2): 18-19.

  3. Masakazu Nagahori, Toshimitsu Fujii, Eiko Saito, Kazuo Ohtsuka, Mamoru Watanabe: Biologics treatment for ulcerative colitis. Nihon Shokakibyo Gakkai Zasshi. 2013.11; 110 (11): 1909-1915. ( PubMed )

  4. Masahiro Takahara, Yasuhiro Nemoto, Shigeru Oshima, Yu Matsuzawa, Takanori Kanai, Ryuichi Okamoto, Kiichiro Tsuchiyaa, Tetsuy Nakamura, Kazuhide Yamamoto, Mamoru Watanabe.: IL-7 promotes long-term in vitro survival of unique long-lived memory subset generated from mucosal effector memory CD4+ T cells in chronic colitis mice. Immunol Lett. 2013.11; 156 (1-2): 82-93. ( PubMed , DOI )

  5. Go Ito, Ryuichi Okamoto, Tatsuro Murano, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Tomohiro Mizutani, Shiro Yui, Junko Akiyama-Morio, Yasuhiro Nemoto, Eriko Okada, Akihiro Araki, Kazuo Ohtsuka, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe: Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cells. PLoS ONE. 2013.11; 8 (11): e79693. ( PubMed , DOI )

  6. Yasuhiro Asahina, Kaoru Tsuchiya, Takashi Nishimura, Masaru Muraoka, Yuichiro Suzuki, Nobuharu Tamaki, Yutaka Yasui, Takanori Hosokawa, Ken Ueda, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Masayuki Kurosaki, Nobuyuki Enomoto, Mina Nakagawa, Sei Kakinuma, Mamoru Watanabe, Namiki Izumi: α-fetoprotein levels after interferon therapy and risk of hepatocarcinogenesis in chronic hepatitis C. Hepatology. 2013.10; 58 (4): 1253-1262. ( PubMed , DOI )

  7. Yasuhiro Nemoto, Takanori Kanai, Masahiro Takahara, Shigeru Oshima, Tetsuya Nakamura, Ryuichi Okamoto, Kiichiro Tsuchiya, and Mamoru Watanabe.: Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells. Gut. 2013.08; 62 (8): 1142-1152. ( PubMed , DOI )

  8. Kei Kiyohashi, Sei Kakinuma, Akihide Kamiya, Naoya Sakamoto, Sayuri Nitta, Hideto Yamanaka, Kouhei Yoshino, Junko Fujiki, Miyako Murakawa, Akiko Kusano-Kitazume, Hiromichi Shimizu, Ryuichi Okamoto, Seishin Azuma, Mina Nakagawa, Yasuhiro Asahina, Naoki Tanimizu, Akira Kikuchi, Hiromitsu Nakauchi, Mamoru Watanabe: Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells in mice. Hepatology. 2013.06; 57 (6): 2502-2513. ( PubMed , DOI )

  9. Yasuhiro Nemoto, Takanori Kanai, Masahiro Takahara, Shigeru Oshima, Ryuichi Okamoto, Kiichiro Tsuchiya, Satoshi Matsumoto, Mamoru Watanabe: Th1/Th17-mediated interstitial pneumonia in chronic colitis mice independent of intestinal microbiota. J. Immunol.. 2013.06; 190 (12): 6616-6625. ( PubMed , DOI )

  10. Makoto Naganuma, Toshimitsu Fujii, Reiko Kunisaki, Naoki Yoshimura, Masakazu Takazoe, Yoshiaki Takeuchi, Eiko Saito, Masakazu Nagahori, Keiko Asakura, Toru Takebayashi, Mamoru Watanabe: Incidence and characteristics of the 2009 influenza (H1N1) infections in inflammatory bowel disease patients. J Crohns Colitis. 2013.05; 7 (4): 308-313. ( PubMed , DOI )

  11. Yoshihito Kano, Kiichiro Tsuchiya, Xiu Zheng, Nobukatsu Horita, Keita Fukushima, Shuji Hibiya, Yuhki Yamauchi, Tatsunori Nishimura, Kunihiko Hinohara, Noriko Gotoh, Shinji Suzuki, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe: The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein. Biochem. Biophys. Res. Commun. 2013.03; 432 (1): 175-181. ( PubMed , DOI )

  12. Makoto Naganuma, Masakazu Nagahori, Toshimitsu Fujii, Junko Morio, Eiko Saito, Mamoru Watanabe: Poor recall of prior exposure to varicella zoster, rubella, measles, or mumps in patients with IBD. Inflamm. Bowel Dis.. 2013.02; 19 (2): 418-422. ( PubMed , DOI )

  1. Kyohei Fujita, Makoto Naganuma, Eiko Saito, Shinji Suzuki, Akihiro Araki, Mariko Negi, Hiroshi Kawachi, Mamoru Watanabe: Histologically confirmed IgG4-related small intestinal lesions diagnosed via double balloon enteroscopy. Dig. Dis. Sci.. 2012.12; 57 (12): 3303-3306. ( PubMed , DOI )

  2. Akihiro Araki, Kiichiro Tsuchiya, Shigeru Oshima, Eriko Okada, Shinji Suzuki, Junko Morio Akiyama, Toshimitsu Fujii, Ryuichi Okamoto, Mamoru Watanabe: Endoscopic ultrasound with double-balloon endoscopy for the diagnosis of inverted Meckel's diverticulum: a case report. J Med Case Rep. 2012.09; 6 (1): 328. ( PubMed , DOI )

  3. Kusano-Kitazume A, Sakamoto N, Okuno Y, Sekine-Osajima Y, Nakagawa M, Kakinuma S, Kiyohashi K, Nitta S, Murakawa M, Azuma S, Nishimura-Sakurai Y, Hagiwara M, Watanabe M: Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication. Antimicrob Agents Chemother. 2012.03; 56 (3): 1315-1323. ( PubMed , DOI )

  4. Yamaji O, Nagaishi T, Totsuka T, Onizawa M, Suzuki M, Tsuge N, Hasegawa A, Okamoto R, Tsuchiya K, Nakamura T, Arase H, Kanai T, Watanabe M: The Development of Colitogenic CD4+ T Cells Is Regulated by IL-7 in Collaboration with NK Cell Function in a Murine Model of Colitis. J Immunol. 2012.03; 188 (6): 2524-2536. ( PubMed , DOI )

  5. Yui S, Nakamura T, Sato T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, Nagaishi T, Okamoto R, Tsuchiya K, Clevers H, Watanabe M.: Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell. Nat Med. 2012.03;

  6. Tomohiro Mizutani, Tetsuya Nakamura, Ryo Morikawa, Masayoshi Fukuda, Wakana Mochizuki, Yuhki Yamauchi, Kengo Nozaki, Shiro Yui, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Mamoru Watanabe: Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro. Biochem. Biophys. Res. Commun.. 2012.03; 419 (2): 238-243. ( PubMed , DOI )

  7. Shiro Yui, Tetsuya Nakamura, Toshiro Sato, Yasuhiro Nemoto, Tomohiro Mizutani, Xiu Zheng, Shizuko Ichinose, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Hans Clevers, Mamoru Watanabe: Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell. Nat. Med.. 2012.03; 18 (4): 618-623. ( PubMed , DOI )

  1. Nemoto Y, Kanai T, Shinohara T, Ito T, Nakamura T, Okamoto R, Tsuchiya K, Lipp M, Eishi Y, Watanabe M: Luminal CD4 T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation. Gastroenterology. 2011.12; 141 (6): 2130-2139.e11. ( PubMed , DOI )

  2. Nemoto Y, Kanai T, Shinohara T, Ito T, Nakamura T, Okamoto R, Tsuchiya K, Lipp M, Eishi Y, Watanabe M.: Luminal CD4⁺ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation. Gastroenterology. 2011.12;

  3. Zheng X, Tsuchiya K, Okamoto R, Iwasaki M, Kano Y, Sakamoto N, Nakamura T, Watanabe M: Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis. Inflamm Bowel Dis. 2011.11; 17 (11): 2251-2260. ( PubMed , DOI )

  4. Funaoka Y, Sakamoto N, Suda G, Itsui Y, Nakagawa M, Kakinuma S, Watanabe T, Mishima K, Ueyama M, Onozuka I, Nitta S, Kitazume A, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, Watanabe M: Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 91. J Virol. 2011.06; 85 (12): 5986-5994. ( PubMed , DOI )

  5. Sakamoto N, Nakagawa M, Tanaka Y, Sekine-Osajima Y, Ueyama M, Kurosaki M, Nishida N, Tamori A, Nishimura-Sakurai Y, Itsui Y, Azuma S, Kakinuma S, Hige S, Ito Y, Tanaka E, Hiasa Y, Izumi N, Tokunaga K, Mizokami M, Watanabe M: Association of IL28B variants with response to pegylated-interferon alpha plus ribavirin combination therapy reveals intersubgenotypic differences between genotypes 2a and 2b. J Med Virol. 2011.03; 83 871-878. ( PubMed , DOI )

  6. Masayuki Kurosaki, Yasuhito Tanaka, Nao Nishida, Naoya Sakamoto, Nobuyuki Enomoto, Masao Honda, Masaya Sugiyama, Kentaro Matsuura, Fuminaka Sugauchi, Yasuhiro Asahina, Mina Nakagawa, Mamoru Watanabe, Minoru Sakamoto, Shinya Maekawa, Akito Sakai, Shuichi Kaneko, Kiyoaki Ito, Naohiko Masaki, Katsushi Tokunaga, Namiki Izumi, Masashi Mizokami: Pre-treatment prediction of response to pegylated-interferon plus ribavirin for chronic hepatitis C using genetic polymorphism in IL28B and viral factors. J. Hepatol.. 2011.03; 54 (3): 439-448. ( PubMed , DOI )

  7. Yamamoto M, Sakamoto N, Nakamura T, Itsui Y, Nakagawa M, Nishimura-Sakurai Y, Kakinuma S, Azuma S, Tsuchiya K, Kato T, Wakita T, Watanabe M: Studies on virus kinetics using infectious fluorescence-tagged hepatitis C virus cell culture. Hepatol Res. 2011.03; 41 (3): 258-269. ( PubMed , DOI )

  8. Izumi Onozuka, Sei Kakinuma, Akihide Kamiya, Masato Miyoshi, Naoya Sakamoto, Kei Kiyohashi, Takako Watanabe, Yusuke Funaoka, Mayumi Ueyama, Mina Nakagawa, Naohiko Koshikawa, Motoharu Seiki, Hiromitsu Nakauchi, Mamoru Watanabe: Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice. Biochem. Biophys. Res. Commun.. 2011.03; 406 (1): 134-140. ( PubMed , DOI )

  9. Shinohara T, Nemoto Y, Kanai T, Kameyama K, Okamoto R, Tsuchiya K, Nakamura T, Totsuka T, Ikuta K, Watanabe M: Upregulated IL-7 receptor alpha expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis. J Immunol. 2011.02; 186 (4): 2623-2632. ( PubMed , DOI )

  10. Shinohara T*, Nemoto Y*, Kanai T, Kameyama K, Okamoto R, Tsuchiya K, Nakamura T, Totsuka T, Ikuta K, Watanabe M. *equally contributed: Upregulated IL-7 receptor α expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis. J Immunol. 2011.02;

  11. Ueyama M, Nakagawa M, Sakamoto N, Onozuka I, Funaoka Y, Watanabe T, Nitta S, Kiyohashi K, Kitazume A, Murakawa M, Nishimura-Sakurai Y, Sekine-Osajima Y, Itsui Y, Azuma S, Kakinuma S, Watanabe M:: Serum interleukin-6 levels correlate with resistance to treatment of chronic hepatitis C infection with pegylated-interferon-α2b plus ribavirin. Antiviral Therapy. 2011; 16 1081-1091. ( PubMed , DOI )

  1. Iwasaki M, Tsuchiya K, Okamoto R, Zheng X, Kano Y, Okamoto E, Okada E, Araki A, Suzuki S, Sakamoto N, Kitagaki K, Akashi T, Eishi Y, Nakamura T, Watanabe M: Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4. J Gastroenterol. 2010.12; ( PubMed , DOI )

  2. Masakazu Nagahori, Sea Bong Hyun, Teruji Totsuka, Ryuichi Okamoto, Erika Kuwahara, Toru Takebayashi, Makoto Naganuma, Mamoru Watanabe: Prevalence of metabolic syndrome is comparable between inflammatory bowel disease patients and the general population. J. Gastroenterol.. 2010.10; 45 (10): 1008-1013. ( PubMed , DOI )

  3. Kameyama K*, Nemoto Y*, Kanai T, Shinohara T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Totsuka T, Hibi T, Watanabe M. *equally contributed: IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitis. Eur J Immunol. 2010.09;

  4. Kaori Kameyama, Yasuhiro Nemoto, Takanori Kanai, Tamako Shinohara, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Naoya Sakamoto, Teruji Totsuka, Toshifumi Hibi, Mamoru Watanabe: IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitis. Eur J Immunol. 2010.09; 40 (9): 2423-2436. ( PubMed , DOI )

  5. Junko Akiyama, Ryuichi Okamoto, Michiko Iwasaki, Xiu Zheng, Shiro Yui, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe: Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells. Biochem. Biophys. Res. Commun. 2010.03; 393 (4): 662-667. ( PubMed , DOI )

  1. Yasuhiro Itsui, Naoya Sakamoto, Sei Kakinuma, Mina Nakagawa, Yuko Sekine-Osajima, Megumi Tasaka-Fujita, Yuki Nishimura-Sakurai, Gouki Suda, Yuko Karakama, Kako Mishima, Machi Yamamoto, Takako Watanabe, Mayumi Ueyama, Yusuke Funaoka, Seishin Azuma, Mamoru Watanabe: Antiviral effects of the interferon-induced protein guanylate binding protein 1 and its interaction with the hepatitis C virus NS5B protein. Hepatology. 2009.12; 50 (6): 1727-1737. ( PubMed , DOI )

  2. Nemoto Y, Kanai T, Kameyama K, Shinohara T, Sakamoto N, Totsuka T, Okamoto R, Tsuchiya K, Nakamura T, Sudo T, Matsumoto S, Watanabe M: Long-lived colitogenic CD4+ memory T cells residing outside the intestine participate in the perpetuation of chronic colitis. J Immunol. 2009.10; 183 (8): 5059-5068. ( PubMed , DOI )

  3. Nemoto Y, Kanai T, Kameyama K, Shinohara T, Sakamoto N, Totsuka T, Okamoto R, Tsuchiya K, Nakamura T, Sudo T, Matsumoto S, Watanabe M.: Long-lived colitogenic CD4+ memory T cells residing outside the intestine participate in the perpetuation of chronic colitis. J Immunol. 2009.10;

  4. Tomita T, Kanai T, Totsuka T, Nemoto Y, Okamoto R, Tsuchiya K, Sakamoto N, Ohteki T, Hibi T, Watanabe M.: IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis. Eur J Immunol. 2009.10;

  5. Takayuki Tomita, Takanori Kanai, Teruji Totsuka, Yasuhiro Nemoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Naoya Sakamoto, Toshiaki Ohteki, Toshifumi Hibi, Mamoru Watanabe: IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis. Eur J Immunol. 2009.10; 39 (10): 2737-2747. ( PubMed , DOI )

  6. Kanai T, Nemoto Y, Kamada N, Totsuka T, Hisamatsu T, Watanabe M, Hibi T.: Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease. Curr Opin Gastroenterol. 2009.07;

  7. Kanai T, Nemoto Y, Tomita T, Totsuka T, Watanabe M, Hibi T.: Persistent retention of colitogenic CD4+ memory T cells causes inflammatory bowel diseases to become intractable. Inflamm Bowel Dis. 2009.06;

  8. Totsuka T, Kanai T, Nemoto Y, Tomita T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Akiba H, Okumura K, Yagita H, Watanabe M: RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis. J Immunol. 2009.05; 182 (10): 6079-6087. ( PubMed , DOI )

  9. Totsuka T, Kanai T, Nemoto Y, Tomita T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Akiba H, Okumura K, Yagita H, Watanabe M.: RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis. J Immunol. 2009.05;

  10. Onizawa M, Nagaishi T, Kanai T, Nagano K, Oshima S, Nemoto Y, Yoshioka A, Totsuka T, Okamoto R, Nakamura T, Sakamoto N, Tsuchiya K, Aoki K, Ohya K, Yagita H, Watanabe M: Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis. Am J Physiol Gastrointest Liver Physiol. 2009.04; 296 (4): G850-9. ( PubMed , DOI )

  11. Onizawa M, Nagaishi T, Kanai T, Nagano K, Oshima S, Nemoto Y, Yoshioka A, Totsuka T, Okamoto R, Nakamura T, Sakamoto N, Tsuchiya K, Aoki K, Ohya K, Yagita H, Watanabe M.: Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis. Am J Physiol Gastrointest Liver Physiol. 2009.04;

  12. Minekazu Murayama, Ryuichi Okamoto, Kiichiro Tsuchiya, Junko Akiyama, Tetsuya Nakamura, Naoya Sakamoto, Takanori Kanai, Mamoru Watanabe: Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells. J. Gastroenterol.. 2009.03; 44 (3): 173-182. ( PubMed , DOI )

  13. Ryuichi Okamoto, Kiichiro Tsuchiya, Yasuhiro Nemoto, Junko Akiyama, Tetsuya Nakamura, Takanori Kanai, Mamoru Watanabe: Requirement of Notch activation during regeneration of the intestinal epithelia. Am J Physiol Gastrointest Liver Physiol. 2009.01; 296 (1): G23-G35. ( PubMed , DOI )

  14. Okamoto R, Tsuchiya K, Nemoto Y, Akiyama J, Nakamura T, Kanai T, Watanabe M.: Requirement of Notch activation during regeneration of the intestinal epithelia. Am J Physiol Gastrointest Liver Physiol. 2009.01;

  1. Toshimitsu Fujii, Takayuki Tomita, Takanori Kanai, Yasuhiro Nemoto, Teruji Totsuka, Naoya Sakamoto, Tetsuya Nakamura, Kiichiro Tsuchiya, Ryuichi Okamoto, Mamoru Watanabe: FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow. Eur J Immunol. 2008.12; 38 (12): 3290-3303. ( PubMed , DOI )

  2. Takayuki Tomita, Takanori Kanai, Yasuhiro Nemoto, Toshimitsu Fujii, Kengo Nozaki, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Naoya Sakamoto, Teruji Totsuka, Mamoru Watanabe: Colitogenic CD4+ effector-memory T cells actively recirculate in chronic colitic mice. Inflamm. Bowel Dis.. 2008.12; 14 (12): 1630-1640. ( PubMed , DOI )

  3. Fujii T, Tomita T, Kanai T, Nemoto Y, Totsuka T, Sakamoto N, Nakamura T, Tsuchiya K, Okamoto R, Watanabe M.: FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow. Eur J Immunol. 2008.12;

  4. Tomita T, Kanai T, Nemoto Y, Fujii T, Nozaki K, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Totsuka T, Watanabe M.: Colitogenic CD4+ effector-memory T cells actively recirculate in chronic colitic mice. Inflamm Bowel Dis. 2008.12;

  5. A Araki, K Tsuchiya, E Okada, S Suzuki, S Oshima, R Okamoto, T Kanai, M Watanabe: Single-operator method for double-balloon endoscopy: a pilot study. Endoscopy. 2008.11; 40 (11): 936-938. ( PubMed , DOI )

  6. Nemoto Y, Kanai T, Tohda S, Totsuka T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Fukuda T, Miura O, Yagita H, Watanabe M: Negative feedback regulation of colitogenic CD4+ T cells by increased granulopoiesis. Inflamm Bowel Dis. 2008.11; 14 (11): 1491-1503. ( PubMed , DOI )

  7. Nemoto Y, Kanai T, Tohda S, Totsuka T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Fukuda T, Miura O, Yagita H, Watanabe M.: Negative feedback regulation of colitogenic CD4+ T cells by increased granulopoiesis. Inflamm Bowel Dis. 2008.11;

  8. Atsushi Yoshioka, Ryuichi Okamoto, Shigeru Oshima, Junko Akiyama, Kiichiro Tsuchiya, Tetsuya Nakamura, Takanori Kanai, Mamoru Watanabe: Flagellin stimulation suppresses IL-7 secretion of intestinal epithelial cells. Cytokine. 2008.10; 44 (1): 57-64. ( PubMed , DOI )

  9. Kimihiro Hino, Kiichiro Tsuchiya, Taro Fukao, Kotaro Kiga, Ryuichi Okamoto, Takanori Kanai, Mamoru Watanabe: Inducible expression of microRNA-194 is regulated by HNF-1alpha during intestinal epithelial cell differentiation. RNA. 2008.07; 14 (7): 1433-1442. ( PubMed , DOI )

  10. Teruji Totsuka, Takanori Kanai, Yasuhiro Nemoto, Takayuki Tomita, Kiichiro Tsuchiya, Naoya Sakamoto, Ryuichi Okamoto, Mamoru Watanabe: Immunosenescent colitogenic CD4(+) T cells convert to regulatory cells and suppress colitis. Eur J Immunol. 2008.05; 38 (5): 1275-1286. ( PubMed , DOI )

  11. Takayuki Tomita, Takanori Kanai, Toshimitsu Fujii, Yasuhiro Nemoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Teruji Totsuka, Naoya Sakamoto, Mamoru Watanabe: Continuous generation of colitogenic CD4(+) T cells in persistent colitis. Eur J Immunol. 2008.05; 38 (5): 1264-1274. ( PubMed , DOI )

  12. Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N, Watanabe M.: Continuous generation of colitogenic CD4(+) T cells in persistent colitis. Eur J Immunol. 2008.05;

  13. Totsuka T, Kanai T, Nemoto Y, Tomita T, Tsuchiya K, Sakamoto N, Okamoto R, Watanabe M.: Immunosenescent colitogenic CD4(+) T cells convert to regulatory cells and suppress colitis. Eur J Immunol. 2008.05;

  14. Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N, Akira S, Watanabe M: MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis. J Immunol. 2008.04; 180 (8): 5291-5299. ( PubMed )

  15. Mikayo Aragaki, Kiichiro Tsuchiya, Ryuichi Okamoto, Sanae Yoshioka, Tetsuya Nakamura, Naoya Sakamoto, Takanori Kanai, Mamoru Watanabe: Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer. Biochem. Biophys. Res. Commun. 2008.04; 368 (4): 923-929. ( PubMed , DOI )

  16. Tomita T, Kanai T, Fujii T, Nemoto Y, Okamoto R, Tsuchiya K, Totsuka T, Sakamoto N, Akira S, Watanabe M.: MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis. J Immunol. 2008.04;

  17. Y Ito, T Kanai, T Totsuka, R Okamoto, K Tsuchiya, Y Nemoto, A Yoshioka, T Tomita, T Nagaishi, N Sakamoto, T Sakanishi, K Okumura, H Yagita, M Watanabe: Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis. Am J Physiol Gastrointest Liver Physiol. 2008.01; 294 (1): G199-G207. ( PubMed , DOI )

  18. Tomita T, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Sakamoto N, Watanabe M: Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis. J Immunol. 2008.01; 180 (1): 383-390. ( PubMed )

  19. Ito Y, Kanai T, Totsuka T, Okamoto R, Tsuchiya K, Nemoto Y, Yoshioka A, Tomita T, Nagaishi T, Sakamoto N, Sakanishi T, Okumura K, Yagita H, Watanabe M.: Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis. Am J Physiol Gastrointest Liver Physiol. 2008.01;

  20. Tomita T, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Sakamoto N, Watanabe M.: Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis. J Immunol. 2008.01;

  1. Makita S, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Yamamoto M, Kiyono H, Watanabe M: Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation. J Immunol. 2007.04; 178 (8): 4937-4946. ( PubMed )

  2. Totsuka T, Kanai T, Nemoto Y, Makita S, Okamoto R, Tsuchiya K, Watanabe M: IL-7 Is essential for the development and the persistence of chronic colitis. J Immunol. 2007.04; 178 (8): 4737-4748. ( PubMed )

  3. Makita S, Kanai T, Nemoto Y, Totsuka T, Okamoto R, Tsuchiya K, Yamamoto M, Kiyono H, Watanabe M.: Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation. J Immunol. 2007.04;

  4. Totsuka T, Kanai T, Nemoto Y, Makita S, Okamoto R, Tsuchiya K, Watanabe M.: IL-7 Is essential for the development and the persistence of chronic colitis. J Immunol. 2007.04;

  5. Kanai T, Makita S, Kawamura T, Nemoto Y, Kubota D, Nagayama K, Totsuka T, Watanabe M.: Extracorporeal elimination of TNF-alpha-producing CD14(dull)CD16(+) monocytes in leukocytapheresis therapy for ulcerative colitis. Inflamm Bowel Dis. 2007.03;

  6. Nagawa F, Kishishita N, Shimizu K, Hirose S, Miyoshi M, Nezu J, Nishimura T, Nishizumi H, Takahashi Y, Hashimoto S, Takeuchi M, Miyajima A, Takemori T, Otsuka AJ, Sakano H: Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice. Nature immunology. 2007.02; 8 (2): 206-13. ( PubMed , DOI )

  7. Yasuhiro Nemoto, Takanori Kanai, Shin Makita, Ryuichi Okamoto, Teruji Totsuka, Kiyoshi Takeda, Mamoru Watanabe: Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis. Gastroenterology. 2007.01; 132 (1): 176-189. ( PubMed , DOI )

  8. Tsuchiya K, Nakamura T, Okamoto R, Kanai T, Watanabe M: Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer. Gastroenterology. 2007.01; 132 (1): 208-220. ( PubMed , DOI )

  9. Nemoto Y, Kanai T, Makita S, Okamoto R, Totsuka T, Takeda K, Watanabe M.: Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis. Gastroenterology. 2007.01;

  1. R Fujii, T Kanai, Y Nemoto, S Makita, S Oshima, R Okamoto, K Tsuchiya, T Totsuka, M Watanabe: FTY720 suppresses CD4+CD44highCD62L- effector memory T cell-mediated colitis. Am J Physiol Gastrointest Liver Physiol. 2006.08; 291 (2): G267-G274. ( PubMed , DOI )

  2. Fujii R, Kanai T, Nemoto Y, Makita S, Oshima S, Okamoto R, Tsuchiya K, Totsuka T, Watanabe M.: FTY720 suppresses CD4+CD44highCD62L- effector memory T cell-mediated colitis. Am J Physiol Gastrointest Liver Physiol. 2006.08;

  3. Kanai T, Uraushihara K, Totsuka T, Nemoto Y, Fujii R, Kawamura T, Makita S, Sawada D, Yagita H, Okumura K, Watanabe M.: Ameliorating effect of saporin-conjugated anti-CD11b monoclonal antibody in a murine T-cell-mediated chronic colitis. J Gastroenterol Hepatol. 2006.06;

  4. Ryuichi Okamoto, Tomoko Matsumoto, Mamoru Watanabe: Regeneration of the intestinal epithelia: regulation of bone marrow-derived epithelial cell differentiation towards secretory lineage cells. Hum. Cell. 2006.05; 19 (2): 71-75. ( PubMed , DOI )

  5. Kanai T, Tanimoto K, Nemoto Y, Fujii R, Makita S, Totsuka T, Watanabe M.: Naturally arising CD4+CD25+ regulatory T cells suppress the expansion of colitogenic CD4+CD44highCD62L- effector memory T cells. Am J Physiol Gastrointest Liver Physiol. 2006.05;

  6. Kanai T, Kawamura T, Dohi T, Makita S, Nemoto Y, Totsuka T, Watanabe M.: TH1/TH2-mediated colitis induced by adoptive transfer of CD4+CD45RBhigh T lymphocytes into nude mice. Inflamm Bowel Dis. 2006.02;

  1. Ryuichi Okamoto, Mamoru Watanabe: Cellular and molecular mechanisms of the epithelial repair in IBD. Dig. Dis. Sci.. 2005.10; 50 Suppl 1 S34-S38. ( PubMed , DOI )

  2. Teruji Totsuka, Takanori Kanai, Shin Makita, Rei Fujii, Yasuhiro Nemoto, Shigeru Oshima, Ryuichi Okamoto, Akemi Koyanagi, Hisaya Akiba, Ko Okumura, Hideo Yagita, Mamoru Watanabe: Regulation of murine chronic colitis by CD4+CD25- programmed death-1+ T cells. Eur J Immunol. 2005.06; 35 (6): 1773-1785. ( PubMed , DOI )

  3. Matsumoto T, Okamoto R, Yajima T, Mori T, Okamoto S, Ikeda Y, Mukai M, Yamazaki M, Oshima S, Tsuchiya K, Nakamura T, Kanai T, Okano H, Inazawa J, Hibi T, Watanabe M: Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine. Gastroenterology. 2005.06; 128 (7): 1851-1867. ( PubMed )

  4. Totsuka T, Kanai T, Makita S, Fujii R, Nemoto Y, Oshima S, Okamoto R, Koyanagi A, Akiba H, Okumura K, Yagita H, Watanabe M.: Regulation of murine chronic colitis by CD4+CD25- programmed death-1+ T cells. Eur J Immunol. 2005.06;

  5. Shin Namiki, Tetsuya Nakamura, Shigeru Oshima, Motomi Yamazaki, Yuko Sekine, Kiichiro Tsuchiya, Ryuichi Okamoto, Takanori Kanai, Mamoru Watanabe: IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome. FEBS Lett.. 2005.05; 579 (13): 2781-2787. ( PubMed , DOI )

  6. Hea Saeng Koh, Atsushi Matsui, Sumie Mimura, Mie Inao, Eiko Saitoh, Akihiko Ohno, Sumiko Nagoshi, Takayuki Yoshimoto, Satoshi Mochida, Kenji Fujiwara: Increased cytoprotective function in the liver of transgenic mice expressing osteopontin in hepatocytes. Hepatol Res. 2005.05; 32 (1): 46-51. ( PubMed , DOI )

  7. Eiko Saitoh, Atsushi Matsui, Mie Inao, Sumie Mimura, Heasaeng Koh, Akihiko Ohno, Sumiko Nagoshi, Hidekazu Kayano, Takayuki Yoshimoto, Satoshi Mochida, Kenji Fujiwara: Extrahepatic manifestations in transgenic mice of osteopontin in hepatocytes-A clue to advent of pathological state in various organs of chronic hepatitis C patients. Hepatol Res. 2005.04; 31 (4): 197-202. ( PubMed , DOI )

  8. Eriko Okada, Motomi Yamazaki, Masanobu Tanabe, Tsutomu Takeuchi, Masanobu Nanno, Shigeru Oshima, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Takanori Kanai, Toshifumi Hibi, Mamoru Watanabe: IL-7 exacerbates chronic colitis with expansion of memory IL-7Rhigh CD4+ mucosal T cells in mice. Am J Physiol Gastrointest Liver Physiol. 2005.04; 288 (4): G745-G754. ( PubMed , DOI )

  1. Kanazawa N, Kurosaki M, Sakamoto N, Enomoto N, Itsui Y, Yamashiro T, Tanabe Y, Maekawa S, Nakagawa M, Chen CH, Kakinuma S, Oshima S, Nakamura T, Kato T, Wakita T, Watanabe M: Regulation of hepatitis C virus replication by interferon regulatory factor 1. J Virol. 2004.09; 78 (18): 9713-9720. ( PubMed , DOI )

  2. Oshima S, Nakamura T, Namiki S, Okada E, Tsuchiya K, Okamoto R, Yamazaki M, Yokota T, Aida M, Yamaguchi Y, Kanai T, Handa H, Watanabe M: Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. Mol Cell Biol. 2004.07; 24 (14): 6298-6310. ( PubMed , DOI )

  3. Satoshi Mochida, Takayuki Yoshimoto, Sumie Mimura, Mie Inao, Atsushi Matsui, Akihiko Ohno, HeaSaeng Koh, Eiko Saitoh, Sumiko Nagoshi, Kenji Fujiwara: Transgenic mice expressing osteopontin in hepatocytes as a model of autoimmune hepatitis. Biochem Biophys Res Commun. 2004.04; 317 (1): 114-120. ( PubMed , DOI )

  4. Kenichi Ishii, Takanori Kanai, Teruji Totsuka, Koji Uraushihara, Takahiro Ishikura, Motomi Yamazaki, Ryuichi Okamoto, Akihiro Araki, Tatsuya Miyata, Katsuaki Tezuka, Tetsuya Nakamura, Mamoru Watanabe: Hyperexpression of inducible costimulator on lamina propria mononuclear cells in rat dextran sulfate sodium colitis. J. Gastroenterol. Hepatol.. 2004.02; 19 (2): 174-181. ( PubMed )

  5. Ryuichi Okamoto, Mamoru Watanabe: Molecular and clinical basis for the regeneration of human gastrointestinal epithelia. J. Gastroenterol.. 2004.01; 39 (1): 1-6. ( PubMed , DOI )

  1. Ryuichi Okamoto, Mamoru Watanabe: Prospects for regeneration of gastrointestinal epithelia with donor derived cells. Trends Mol Med. 2003.09; 9 (7): 286-290.

  2. Motomi Yamazaki, Tomoharu Yajima, Masanobu Tanabe, Kazuto Fukui, Eriko Okada, Ryuichi Okamoto, Shigeru Oshima, Tetsuya Nakamura, Takanori Kanai, Masahiro Uehira, Tsutomu Takeuchi, Hiromichi Ishikawa, Toshifumi Hibi, Mamoru Watanabe: Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis. J. Immunol.. 2003.08; 171 (3): 1556-1563. ( PubMed )

  3. Mamoru Watanabe, Motomi Yamazaki, Ryuichi Okamoto, Shinya Ohoka, Akihiro Araki, Tetsuya Nakamura, Takanori Kanai: Therapeutic approaches to chronic intestinal inflammation by specific targeting of mucosal IL-7/IL-7R signal pathway. Curr Drug Targets Inflamm Allergy. 2003.06; 2 (2): 119-123. ( PubMed )

  4. Teruji Totsuka, Takanori Kanai, Ryoichi Iiyama, Koji Uraushihara, Motomi Yamazaki, Ryuichi Okamoto, Toshifumi Hibi, Katsunari Tezuka, Miyuki Azuma, Hisaya Akiba, Hideo Yagita, Ko Okumura, Mamoru Watanabe: Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis. Gastroenterology. 2003.02; 124 (2): 410-421. ( PubMed , DOI )

  1. Okamoto R, Yajima T, Yamazaki M, Kanai T, Mukai M, Okamoto S, Ikeda Y, Hibi T, Inazawa J, Watanabe M: Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract. Nat Med. 2002.09; 8 (9): 1011-1017. ( PubMed , DOI )

  1. Takanori Kanai, Mamoru Watanabe, Akira Okazawa, Toshiro Sato, Motomi Yamazaki, Susumu Okamoto, Hiromasa Ishii, Teruji Totsuka, Ryoichi Iiyama, Ryuichi Okamoto, Masao Ikeda, Masashi Kurimoto, Kiyoshi Takeda, Shizuo Akira, Toshifumi Hibi: Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease. Gastroenterology. 2001.10; 121 (4): 875-888. ( PubMed )

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