1. Shuji Hibiya, Kento Takenaka, Ryuichi Okamoto. Comparison of the efficacy of biologics for intestinal stricture in Crohn's disease. 第107回日本消化器内視鏡学会総会 2024.05.31 国際館パミール

  2. Ami Kawamoto, Kento Takenaka, Ryuichi Okamoto. Efficacy of biomarkers in predicting prognosis of Crohn’s disease patients with small bowel disease. 第107回日本消化器内視鏡学会総会 2024.05.30 国際館パミール

  3. K Matsuoka, S Motoya, T Yamamoto, M Matsuura, T Fujii, S Shinzaki, Y Mikami, S Arai, J Oshima, Y Endo, H Yuasa, M Hoshi, K Sato, T Hisamatsu. Post-marketing surveillance of tofacitinib in patients with ulcerative colitis in Japan: a final report of safety and effectiveness data. DDW2024 米国消化器病学会 2024.05.19 Walter E. Washington Convention Center_ Washington, D.C.

  4. Hiroshi Nakase, Toshimitsu Fujii, Tadakazu Hisamatsu, Yasuo Suzuki, Mamoru Watanabe, Yoko Uchikawa, Shoichiro Goto, Go Fujimoto, Changliang Zhang, Toshifumi Hibi. Ozanimod as induction and maintenance therapy for ulcerative colitis: a randomized, double-blind, placebo-controlled study in Japan (J-True North). DDW2024 米国消化器病学会 2024.05.19 Walter E. Washington Convention Center_ Washington, D.C.

  5. 藤井 悟, 水谷 知裕, 清水 寛路, 岡本 隆一. クローン病小腸病変に対する自家移植可能な小腸上皮オルガノイド培養法の開発. 第110回日本消化器病学会総会 2024.05.10 アスティとくしま

  6. Shun Kaneko. The Progress of Internal Medicine for Intrahepatic Cholangiocarcinoma. The 33rd Annual Meeting of the Asian Pacific Association for the Study of the Liver 2024.03.29 Kyoto International Conference Hall, Kyoto

  7. Inoue T, Fushimi M, Yamada D, Watabe T, Watanabe M, Okamoto R, Nagaishi T. Downregulated apelin expression in T cells in the setting of chronic colitis. ECCO 2024.02.23 Stockholmsmässan_Stockholm

  8. Katsuyoshi Matsuoka, Satoshi Motoya, Takayuki Yamamoto, Minoru Matsuura, Toshimitsu Fujii, Shinichiro Shinzaki, Yohei Mikami, Shoko Arai, Junichi Oshima, Yutaka Endo, Hirotoshi Yuasa, Masato Hoshi, Keiko Sato, Tadakazu Hisamatsu. Post-marketing surveillance of tofacitinib in patients with ulcerative colitis in Japan: a final report of effectiveness and safety data. 19th Congress of ECCO 2024.02.23 Stockholmsmässan_Stockholm

  9. N.Takatsu, T.Yamamoto, H.Nakase, S.Shinzaki, K.Watanabe, T.Fujii, R.Okamoto, K.Matsuoka, A.Yamada, R.Kunisaki, M.Matsuura, H.Shiga, S.Bamba, Y.Mikami, T.Shimoyama, S.Motoya, T.Torisu, T.Kobayashi, N.Ohmiya, M.Saruta, S.Yoshigoe, Y.Murata, T.Hisamatsu. Clinical features and surgical necessity rate of fistulisingperianal disease in newly diagnosed patients with Crohn's disease: Interim analysis of inception cohort registry study of patients with Crohn's disease (iCREST-CD). 19th Congress of ECCO 2024.02.23 Stockholmsmässan_Stockholm

  10. Katsuyoshi Matsuoka, Hiroshi Nakase, Toshimitsu Fujii, Tadakazu Hisamatsu, Yasuo Suzuki, Mamoru Watanabe, Yoko Uchikawa, Shoichiro Goto, Go Fujimoto, Changliang Zhang, Toshifumi Hibi. Ozanimod as a once-daily oral therapy for Japanese patients with ulcerative colitis: results from the induction period of a phase 2/3 study (J-True North). 19th Congress of ECCO 2024.02.23 Stockholmsmässan_Stockholm

  11. Inoue T, Fushimi M, Tsugawa N, Yamada D, Watabe T, Watanabe M, Okamoto R, Adachi T, Blumberg RS, Nagaishi T. B cell receptor signaling-mediated activation in lymphoid tissues is regulated by the long isoform of CEACAM1. 第52回日本免疫学会学術集会 2024.01.19 幕張メッセ

  12. Fushimi M, Inoue T, Yamada D, Kojima Y, Hosoya A, Watabe T, Watanabe M, Okamoto R, Nagaishi T. APL downregulation in T cells in an animal model of chronic colitis. 第52回日本免疫学会学術集会 2024.01.19 幕張メッセ

  1. Ryuichi Okamoto. Clinical Application of Patient-derived Organoids. World Bio Innovation Forum Invitation 2023.12.06 WEB

  2. Kento Takenaka. Deep neural network for video colonoscopy of ulcerative colitis. JDDW2023 2023.11.04 Kobe_Japan

  3. Shun Kaneko, Yasuhiro Asahina, Miyako Murakawa, Ryuichi Okamoto. Liver stiffness stratify the disease progression and hepatocellular carcinoma predictive risk score on chronic hepatitis B patients. JDDW2023 2023.11.03 Kobe_Japan

  4. Marla C. Dubinsky, Geert D’Haens, Olivier Dewit, Pascal Juillerat, Remo Panaccione, Toshimitsu Fujii, Ana P Lacerda, Elena Dubcenco, Samuel Anyanwu, Chirag Doshi, John Liu, Andrew Garrison, Edward V Loftus Jr. Corticosteroid-Sparing Effect of Upadacitinib in Patients With Moderately to Severely Active Crohn’s Disease. ACG 2023 - American College of Gastroenterology 2023.10.20 Vancouver_Canada

  5. B.Bressler, L.Peyrin-Biroulet, J.R.Allegretti, K.G.Huang, M.Germinaro, N.Shipitofsky, Y.Miao, H.Zhang, M.Bortlik, T.Hlavaty, T.Fujii, B.G.Feagan, B.E.Sands, A.Dignass on behalf of the QUASAR Investigators. The Efficacy of Induction Treatment With Guselkumab in Patients with Moderately to Severely Active Ulcerative Colitis: Phase 3 QUASAR Induction Study Results at Week 12 by Prior Advanced Therapy History. ACG 2023 - American College of Gastroenterology 2023.10.20 Vancouver_Canada

  6. Mone Fushimi, Tadahiko Inoue, Daiki Yamada, Taro Watabe, Mamoru Watanabe, Ryuichi Okamoto, Takashi Nagaishi. APL downregulation in T cells in the setting of chronic colitis. UEGW2023 2023.10.15 Copenhagen_Denmark

  7. T. Fujii , S. Hibiya , H. Shimizu , A. Kawamoto , K. Takenaka , E. Saito , M. Nagahori , K. Ohtsuka , R. Okamoto. DUAL THERAPY WITH CAROTEGRAST (AJM300: ORAL α4 INTEGRIN ANTAGONIST) AND BIOLOGICS FOR REFRACTORY ULCERATIVE COLITIS. UEGW2023 2023.10.15 Copenhagen_Denmark

  8. Minhu Chen, Xiang Gao, Kenji Watanabe, Toshimitsu Fujii, Jae Hee Cheon, Shu-Chen Wei, Dennis Teng, Ana P Lacerda, Valencia P Remple, Hiroshi Nakase. Efficacy of Induction Upadacitinib Therapy in East Asian Patients With Moderately to Severely Active Crohn’s Disease. UEGW2023 2023.10.15 Copenhagen_Denmark

  9. B.Bressler, L.Peyrin-Biroulet, J.R.Allegretti, K.G.Huang, M.Germinaro, N.Shipitofsky, Y.Miao, H.Zhang, M.Bortlik, T.Hlavaty, T.Fujii, B.G.Feagan, B.E.Sands, A.Dignass on behalf of the QUASAR Investigators. The Efficacy of Induction Treatment With Guselkumab in Patients with Moderately to Severely Active Ulcerative Colitis: Phase 3 QUASAR Induction Study Results at Week 12 by Prior Advanced Therapy History. UEGW2023 2023.10.15 Copenhagen_Denmark

  10. A. Kawamoto, K. Takenaka, S. Hibiya, Y. Kitazume, K. Ito, H. Shimizu, T. Fujii, E. Saito, K. Ohtsuka, R. Okamoto. COMBINING LEUCINE-RICH ALPHA-2 GLYCOPROTEIN AND FAECAL BIOMARKERS FOR ACCURATE MONITORING OF SMALL BOWEL ACTIVITY IN CROHN’S DISEASE. UEGW2023 2023.10.14 Copenhagen_Denmark

  11. Hiromune Katsuda, Go Ito, Yui Hiraguri, Tomohiro Muto, Shun Ishido, Masanori Kobayashi, Hironari Yamashita, Akira Ito, Hiroaki Ono, Atsushi Kudo, Mamoru Watanabe, Minoru Tanabe, Ryuichi Okamoto. Analysis of gene expression to elucidate the pathogenesis of pancreatic solid pseudopapillary neoplasm. UEGW2023 2023.10.14 Copenhagen_Denmark

  12. Shuij Hibiya, Takashi Fujii, Toshimitsu Fujii, Kazuo Ohtsuka, Ryuichi Okamoto. Severe COVID-19 is associated with risk of lower gastrointestinal bleeding. UEGW2023 2023.10.14 Copenhagen_Denmark

  13. Shiro Yui. Fetal-like reprogramming is the key to understand the heterogeneity of colorectal cancer. SICS-OMICS2023, The 41st Sapporo International Cancer Symposium 2023.10.13 Tokyo, Japan

  14. Marc Ferrante, Laurent Peyrin-Biroulet, Axel Dignass, David T. Rubin, Silvio Danese, Geert D'Haens, Kristina Kligys, Sofie Berg, Jasmina Kalabic, Javier Zambrano, Yafei Zhang, Toshimitsu Fujii, and Remo Panaccione. Clinical and Endoscopic Improvements with Risankizumab Induction and Maintenance Dosing Versus Placebo are Observed Irrespective of Number of Prior Failed Biologics. UEGW2023 2023.10.11 Copenhagen_Denmark

  15. Marla C. Dubinsky, Geert D’Haens, Olivier Dewit, Pascal Juillerat, Remo Panaccione, Toshimitsu Fujii, Ana P Lacerda, Elena Dubcenco, Samuel Anyanwu, Chirag Doshi, Madhuja Mallick, Andrew Garrison, John Liu, Edward V Loftus Jr. Corticosteroid discontinuation and clinical outcomes in patients with moderately to severely active Crohn’s disease treated with upadacitinib. SGG Swiss congress 2023 2023.09.23 Interlaken_Switzerland

  16. Nobuhiko Ogasawara, Shiro Yui et al. ECM-niche dependent plasticity controls the acquisition of invasive phenotype in colorectal cancer. 第82回日本癌学会学術総会 2023.09.21 Yokohama

  17. Nobuhiko Ogasawara, Yoshihito Kano, Sakurako Kobayashi, Satoshi Watanabe, Sakura Kirino, Iichiroh Onishi, Shinichi Yamauchi, Yui Hiraguri, Go Ito, Mamoru Watanabe, Yusuke Kinugasa, Kenichi Ohashi, Ryuichi Okamoto, Shiro Yui. ECM-niche dependent plasticity controlsthe acquisition of invasive phenotype in colorectal cancer. The 82nd Annual Meeting Of The Japanese Cancer Association 2023.09.21 Yokohama_Japan

  18. Mina Nakagawa, Miyako Murakawa, Masato Miyoshi, Shun Kaneko, Fukiko Kawai-Kitahata, Sayuri Nitta, Sei Kakinuma, Yasuhiro Asahina, Ryuichi Okamoto. Factors associated with HCC development and patients’ survival in patients with an SVR. The 3rd JSH International Liver Conference 2023.09.07

  19. Marla C. Dubinsky, Geert D’Haens, Olivier Dewit, Pascal Juillerat, Remo Panaccione, Toshimitsu Fujii, Ana P Lacerda, Elena Dubcenco, Samuel Anyanwu, Chirag Doshi, Madhuja Mallick, Andrew Garrison, John Liu, Lena Thin, Edward V Loftus Jr. Corticosteroid discontinuation and clinical outcomes in patients with moderately to severely active Crohn’s disease treated with upadacitinib. AGW2023 2023.09.02 Brisbane_Australia

  20. Kazuo Ohtsuka. Endoscopic and imaging diagnosis and assessment of inflammatory bowel disease. 7th TASSID TSIBD Joint Symposium 2023.08.05 Tainan_Taiwan

  21. Kazuo Ohtsuka, Kento Takenaka, Ryuichi Okamoto. Cutting-edge of clinical practice in SBE. The 105th Congress of the Japan Gastroenterological Endoscopy Society 2023.05.26 Tokyo_Japan

  22. Ryuichi Okamoto, Yasuhiro Nemoto, Tomohiro Mizutani, Hiromichi Shimizu. Recent Progress in the Treatment of Tissue Specific Immunological Diseases. The 2nd International Symposium of Clinical Immunology 2023.05.19 Kamakura_JAPAN

  23. Nobuhiko Ogasawara, Yoshihito Kano, Sakurako Kobayashi, Satoshi Watanabe, Sakura Kirino, Shinichi Yamauchi, Yui Hiraguri, Go Ito, Tomohiro Mizutani, Mamoru Watanabe, Yusuke Kinugasa, Ryuichi Okamoto, Shiro Yui. Unveiling the gene network behind cell plasticity provides a novel insight into the therapeutic approach for human colorectal cancer. Keystone Symposia 2023.05.11 Vancouver_Canada

  24. Marla C. Dubinsky, Geert D’Haens, Olivier Dewit, Pascal Juillerat, Remo Panaccione, Toshimitsu Fujii, Ana P. Lacerda, Elena Dubcenco, Samuel Anyanwu, Chirag Doshi, Madhuja Mallick, Andrew Garrison, John Liu, Edward V. Loftus Jr. Corticosteroid Discontinuation and Clinical Outcomes in Patients With Moderately to Severely Active Crohn’s Disease Treated With Upadacitinib. DDW2023 2023.05.09 Washington,D.C._USA

  25. Marc Ferrante, Qian Cao, Toshimitsu Fujii, Astrid Rausch, Ezequiel Neimark, Alexandra Song, Kori Wallace, Kristina Kligys, Qing Zhou, Jasmina Kalabic, Brian Feagan. Patients with Moderate-to-Severe Crohn’s Disease with and without Prior Biologic Failure Demonstrate Improved Endoscopic Outcomes with Risankizumab: Results from Phase 3 Induction and Maintenance Trials Marc. DDW2023 2023.05.09 Washington,D.C._USA

  26. Ryuichi Okamoto. Bench-to-bedside research: Patient-derived organoid transplantation for treatment of intractable ulcerative colitis. SIDDS 2023 2023.04.08 Grand Walkerhill Seoul_Korea

  27. M.C. Dubinsky, G. D’Haens, O. Dewit, P. Juillerat, R. Panaccione, T. Fujii, A.P. Lacerda, E. Dubcenco, S.Anyanwu, C. Doshi, M. Mallick, A. Garrison, J. Liu, E.V. Loftus Jr.. Corticosteroid discontinuation and clinical outcomes in patients with moderately to severely active Crohn's disease treated with upadacitinib. 18th Congress of ECCO 2023.03.02 Copenhagen_Denmark

  28. Junichi Takahashi, Tomohiro Mizutani, Ryuichi Okamoto. A suspension method for efficient induction and maturation of human intestinal organoids using a rotational bioreactor. 2023 RIKEN BDR-CuSTOM Joint Organoid Symposium 2023.02.17 Kobe_Japan

  29. Junichi Takahashi, Tomohiro Mizutani, Ryuichi Okamoto. A suspension method for efficient induction and maturation of human intestinal organoids using a rotational bioreactor. 2023 RIKEN BDR-CuSTOM Joint Organoid Symposium 2023.02.15 Kobe_Japan

  1. Yasuhiro Asahina. HCC development and surveillance after SVR. JDDW 2022, JSH-AASLD joint symposium 2022.10.27

  2. Marc Ferrante, Laurent Peyrin-Biroulet, Axel Dignass, David T. Rubin, Silvio Danese, Geert D'Haens, Kristina Kligys, Sofie Berg, Jasmina Kalabic, Javier Zambrano, Yafei Zhang, Toshimitsu Fujii, and Remo Panaccione. Clinical and Endoscopic Improvements with Risankizumab Induction and Maintenance Dosing Versus Placebo are Observed Irrespective of Number of Prior Failed Biologics. American College of Gastroenterology Annual Scientific Meeting 2022.10.25

  3. Ami Kawamoto. Novel Biomarkers for Small Intestinal Crohn’s Disease. UEG Week 2022 2022.10.11

  4. B.Feagan,J.F.Colombel,J.Torres,T.Fujii,W.Zhou,X.Yao,Y.Sanchez Gonzalez,D.Ilo,X.Roblin. IMPACT OF INFLAMMATORY BURDEN ON EFFICACY OF UPADACITINIB MAINTENANCE THERAPY IN ULCERATIVE COLITIS: RESULTS FROM THE PHASE 3 U-ACHIEVE STUDY. UEGW2022 2022.10.11

  5. Shun Kaneko. The risk factor of hepatocellular carcinoma in chronic hepatitis B patients on nucleos(t)ide analogues therapy. The 6th Joint Session between TDDW - JDDW – KDDW 2022.09.24

  6. Ryuichi Okamoto. Scientific Session 9 : Advances in Regenerative Medicine_Chairperson. AOCC2022 2022.06.22

  7. Watanabe, Satoshi ; Ogasawara, Nobuhiko ; Kobayashi, Sakurako ; Ito, Go ; Kano, Yoshito ; Mizutani, Tomohiro ; Shimizu, Hiromichi ; Watanabe, Mamoru ; Okamoto, Ryuichi ; Yui, Shiro. APPLICATION OF DSS-GRAFTING ASSAY TO EVALUATE THE POTENTIAL OF CECUM ORGANOIDS AS A USEFUL CELLULAR SOURCE FOR THE TREATMENT OF COLITIS. Digestive Disease Week, 2022 2022.05.22 San Diego

  8. Ryo Morikawa,Yasuhiro Nemoto,Yuki Yonemoto,Mamoru Watanabe,Ryuichi Okamoto. Visualization of the interaction between intraepithelial lymphocytes and the intestinal tumor cells both in vitro and in vivo. Digestive Disease Week 2022 2022.05.22

  9. Takahashi, Junichi, Mizutani, Tomohiro ,Okamoto, Ryuichi. A NOVEL SUSPENSION METHOD FOR EFFICIENT INDUCTION AND RAPID MATURATION OF HUMAN INTESTINAL ORGANOIDS USING A ROTATIONAL BIOREACTOR. DDW2022 2022.05

  10. Ryuichi Okamoto. Regenerative medicine and mucosal immunology for IBD. The 1st International Symposium of Clinical Immunology 2022.04.03

  11. M Ferrante, Q Cao, T Fujii, A Rausch, E Neimark, A Song, K Wallace, K Kligys, Q Zhou, J Kalabic, B G Feagan. Patients with moderate to severe Crohn’s Disease with and without prior biologic failure demonstrate improved endoscopic outcomes with risankizumab: Results from phase 3 induction and maintenance trials. ECCO2022 2022.02.18

  1. Kento Takenaka, Kazuo Ohtsuka, Ryuichi Okamoto. Balloon assisted enteroscopy and Magnetic resonance enterograpy for Small bowel Crohn’s disease. JDDW2021 2021.11.06 神戸コンベンションセンター

  2. Shuji Hibiya, Kazuo Ohtsuka, Ryuichi Okamoto. Association between mucosal healing and surgery risk after endoscopic balloon dilatation for small intestinal stricture of Crohn's disease. JDDW2021 2021.11.06 神戸コンベンションセンター(兵庫)

  3. Kent Tkenaka. Higher Concentrations of TNF antibodies are associated with better healing of the small bowel in crohn's disease. JDDW2021 2021.11.05 神戸コンベンションセンター（兵庫）

  4. Mina Nakagawa, Masato Miyoshi, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Yasuhiro Asahina. Factors associated with HCC development and patients’ survival in patients with an SVR. JSH International Liver Conference 2021 2021.10.03

  5. 土屋輝一郎、長堀正和、日比谷秀爾、竹中健人、河本亜美、清水寛路、藤井俊光、齊藤詠子、大塚和朗、渡辺　守、岡本隆一 . 【誌面発表】COVID-19蔓延下におけるスマートデバイスを用いたIBD病診連携に関する研究. 厚生労働科学研究費 難治性疾患政策研究事業 「難治性炎症性腸管障害に関する調査研究」令和3年度 第1回総会 2021.07.15 Web開催

  6. Takashi Nagaishi. BCR signaling-mediated activation in lymphoid tissues is regulated by the long isoform of Ceacam1.. DDW2021 2021.05.21 Online

  7. Kento Takenaka. Deep Neural Network for Accurate Evaluation of Endoscopic Images from Patients with Ulcerative Colitis. IMKASID 2021 2021.04.16 Online

  1. 根本泰宏. Strategic International Session (Symposium)1　ディスカッサント. JDDW2020 2020.11.06

  2. Takashi Nagaishi, Naoya Tsugawa, Daiki Yamada, Yudai Kojima, Michio Onizawa, Taro Watabe, Richard S. Blumberg, Mamoru Watanabe. BCR signaling in lymphoid tissues regulated by the long isoform of Ceacam1.. FOCIS2020 2020.10.28 Web開催

  3. Takashi Nagaishi, Daiki Yamada, Naoya Tsugawa, Taro Watabe, Eiko Saito, Masayoshi Fukuda, Ayako Arai, Kazuo Ohtsuka, Mamoru Watanabe. A case of villous atrophy with CCR4+ T cell infiltration in the small intestine.. UEGW2020 2020.10.10 Web開催

  4. 勝倉暢洋、日比谷秀爾、土屋輝一郎. The role of intestinal differentiation system in carcinogenesis of IPMN. 第79回日本癌学会学術総会 2020.10.01 Web開催

  5. Kaneko Shun, Kurosaki Masayuki, Izumi Namiki. B型肝炎診療の最先端2020(The latest in the prevention and treatment of hepatitis B: 2020 update)　Nucleos(t)ide analogue投与中の血清中HBV-DNA量により層別化したB型慢性肝炎患者の肝細胞癌リスク(Serum HBV-DNA during nucleos(t)ide analogues therapy stratifies hepatocellular carcinoma risk on chronic hepatitis B patients). 肝臓 2020.09.01

  6. Fukiko Kawai-Kitahata, Yasuhiro Asahina , Sei Kakinuma, Miyako Murakawa, Sayuri Nitta, Masato Miyoshi, Ayako Sato, Jun Tsuchiya, Taro Shimizu, Eiko Takeichi, Mina Nakagawa, Yasuhiro Itsui, Seishin Azuma, Shinji Tanaka , Minoru Tanabe, Shinya Maekawa, Nobuyuki Enomoto and Mamoru Watanabe. Comprehensive analysis of cancer-related genes and AAV/Hepatitis B virus integration into genome on development of hepatocellular carcinoma in patients with prior Hepatitis B virus infection. EASL The Digital International Liver Congress 2020 2020.08.28 Online

  7. Takashi Nagaishi, Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Yudai Kojima, Richard S. Blumberg, Mamoru Watanabe. BCR signaling in lymphoid tissues is regulated by the long isoform of Ceacam1.. MICS2020 2020.07.20 Web開催

  8. Toshimitsu Fujii, Shuji Hibiya, Chiaki Maeyashiki, Eiko Saito, Kento Takenaka, Maiko Motobayashi, Hiromichi Shimizu, Masakazu Nagahori, Kazuo Ohtsuka, Masayuki Kurosaki, Tsunehito Yauchi, Mamoru Watanabe. Intolerance to 5-aminosalicylate is a risk of poor prognosis in Ulcerative colitis patients.. ECCO2020 2020.02.14 Vienna（Austria）

  9. Takashi Nagaishi, Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Mamoru Watanabe. B cell receptor signaling in lymphoid tissues may be regulated by CEACAM1.. ECCO2020 2020.02.14 Vienna（Austria）

  10. Sakurako Kobayashi, Satoshi Watanabe, Yosuke Yoneyama, Kousuke Tanimoto, Ryu Nishimura, Sayaka Nagata, Masami Inoue, Kouhei Suzuki, Sei Kakinuma, Kiichiro Tsuchiya, Ryuichi Okamoto, Mamoru Watanabe, Takanori Takebe, Shiro Yui. Conceptual basis of lineage shift between intestinal epithelium and hepatocytes. Keystone Symposia, Tissue Organoids as Models of Host Physiology and Pathophysiology of Disease 2020.01.22 Vancouver（Canada）

  1. Takahiro Adachi, Taro Watabe, Takashi Nagaishi, Mamoru Watanabe, Hajime Karasuyama, Soichiro Yoshikawa. IgA-deficiency causes spontaneous enteritis.. The 48th Annual Meeting of the Japanese Society for Immunology 2019.12.13 Hamamatsu（Japan）

  2. Yasuhiro Asahina. Do DAA therapy result in an increased risk of hepatocarcinogenesis?. Asian Pacific Digestive Week 2019 2019.12.13 Kolata（India）

  3. Shiro Yui. Regenerative medicine in treatment of IBD. APDW 2019 2019.12.12 Kolkata (India)

  4. Naoya Tsugawa, Takashi Nagaishi, Daiki Yamada, Toshimitsu Fujii, Yudai Kojima, Arisa Tokai, Taro Watabe, Shuang Wang, Michio Onizawa, Takahiro Adachi, Mamoru Watanabe. BCR signaling in the activated B cells may be regulated by the long isoform of Ceacam1. 第48回日本免疫学会学術集会 2019.12.11 アクトシティ浜松

  5. Yasuhiro Asahina, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Sei Kakinuma. Comprehensive analysis of cancer gene mutations and viral integration in hepatocellular carcinoma arising from non-fibrotic liver. AASLD The Liver Meeting 2019 2019.11.10 Boston（USA）

  6. Shuji Hibiya, Kiichiro Tsuchiya, Ryu Nishimura, Sho Watanabe, Nobuhiro Katsukura, Tomoaki Shirasaki, Ryuichi Okamoto, Mamoru Watanabe. Establishment of chronic inflammation model using human small intestinal and colonic organoids. UEG Week 2019 2019.10.23 Barcelona（Spain）

  7. Yasuhiro Asahina. Prevention and Risk for Liver Cancer after Anti-Viral Therapy in Patients with HBV/HCV. JSH International Liver Conference 2019.10.02 Osaka（Japan）

  8. Kana Otsubo, Yoichi Nibe, Chiaki Maeyashiki, Akiko Tamura, Emi Aonuma, Hiroki Matsuda, Mamoru Watanabe, Shigeru Oshima. The role of ubiquitination in crosstalk of intestinal epithelial cell death and autophagic signaling was revealed by a novel polyubiquitin imaging system.. 19th International congress of mucosal immunology 2019.07.17 the Brisbane Convention & Exhibition Centre(Brisbane, Australia)

  9. Daiki Yamada, Takashi Nagaishi, Taro Watabe, Naoya Tsugawa, Yudai Kojima, Takahiro Adachi, Mamoru Watanabe. Analysis of Ileocecal Immune Response in an Animal Model of Colitis. ICMI 2019 2019.07.17 Brisbane Convention & Exhibition Centre(Brisbane)

  10. Okamoto R, Watanabe M. 【Focus Session: Cutting Edge Regenerative Medicine Using Stem Cells】Intestinal Epithelial Stem Cell Organoids and IBD. ISSCR2019 2019.06.26 Los Angeles（USA）

  11. Takashi Nagaishi, Yudai Kojima, Taro Watabe, Naoya Tsugawa, Daiki Yamada, Nisha Jose, Akinori Hosoya, Masahiro Suzuki, Michio Onizawa, Mamoru Watanabe. Analysis of APL expression in an animal model of chronic colitis. FOCIS2019 2019.06.20 Boston（USA）

  12. Shiro Yui, Mamoru Watanabe. Stem Cells in Gut, Who are They and How They Work, What Can We Count on Them. AOCC2019 2019.06.16 Taipei（Taiwan）

  13. Kento Takenaka, Kazuo Ohtsuka, Toshimitsu Fujii, Kohei Suzuki, Hiromichi Shimizu, Maiko Motobayashi, Shuji Hibiya, Eiko Saito, Masakazu Nagahori, Mamoru Watanabe. Small bowel endoscopic healing of Crohn’s disease treated with anti-TNF antibodies. AOCC2019 2019.06.15 Taipei（Taiwan）

  14. Eiko Saito, Kohei Suzuki, Shuuji Hibiya, Maiko Motobayashi, Kento Takenaka, Nobukatsu Horita, Hiromichi Shimizu, Michio Onizawa, Toshimitsu Fujii, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe. The clinical efficacy of ustekinumab (UST) in patients with Crohn’s disease (CD). AOCC2019 2019.06.15 Taipei（Taiwan）

  15. Daiki Yamada, Takashi Nagaishi, Yudai Kojima, Taro Watabe, Naoya Tsugawa, Nisha Jose, Akinori Hosoya, Masahiro Suzuki, Michio Onizawa, Mamoru Watanabe. APL downregulation in an animal model of chronic colitis. AOCC2019 2019.06.15 Taipei Marriott Hotel

  16. Shuji Hibiya, Kiichiro Tsuchiya, Ryu Nishimura, Tomoaki Shirasaki, Sho Watanabe, Nobuhiro Katsukura, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Long-term inflammation model using human colonic organoids. AOCC2019 2019.06.15 Taipei（Taiwan）

  17. Kawai M, Hama M, Nagata S, Kawamoto A, Suzuki K, Shimizu H, Anzai S, Takahashi J, Kuno R, Takeoka S, Hiraguri Y, Yui S, Okamoto R, Watanabe M. Functional analysis of isoflavones using patient-derived intestinal organoids. AOCC2019 2019.06.14 Taipei（Taiwan）

  18. Ryuichi Okamoto, Mao Kawai, Minami Hama, Sayaka Nagata, Ami Kawamoto, Kohei Suzuki, Hiromichi Shimizu, Sho Anzai, Junichi Takahashi, Reiko Kuno, Sayaka Takeoka, Yui Hiraguri, Shiro Yui, Mamoru Watanabe. 【The 6th JSGE International Topic Conference Lifestyle-related Diseases in Gastroenterology】Gastrointestinal tract（role of gut microbiome and diet）：Food-bome factors in inflammatory bowel disease. The105th General Meeting of the Japanese Society of Gastroenterology 2019.05.10 Kanazawa（Japan）

  19. Miyako Murakawa, Yasuhiro Asahina, Emi Inoue, Mina Nakagawa, Jun Tuchiya, Ayako Sato, Masato Miyoshi, Tomoyuki Tsunoda, Fukiko Kitahata-Kawai, Sayuri Nitta, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Mamoru Watanabe. The association of serum IFN-lambda 3 levels with liver fibrosis and hepatocarcinogenesis in chronic hepatitis C patients treated with direct-acting antiviral agents . EASL, The International Liver Congress 2019 2019.04.13 Vienna （Austria）

  20. MIna Nakagawa, Yasuhiro Asahina, Jun Tsuchiya, Ayako Sato, Tomoyuki Tsunoda, Msato Miyosh, Emi Inoue, Fukiko Kawai-Kitahata, MIyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Makoto Tomita, Mamoru Watanabe. Impact of HCV clearance on HCC development and patient survival: Propensity score-matched analysis of an ongoing database of 2173 CHC patients. EASL, The International Liver Congress 2019 2019.04.13 Messe Wien Congress and Exhibition Center(Vienna （Austria）)

  21. Shun Kaneko, Masayuki Kurosaki, Nobuharu Tamaki, Jun Itakura, Sakura Kirino, Leona Osawa, Keiya Watakabe, Mao Okada, Wan Wang, Takao Shimizu, Mayu Higuchi, Kenta Takaura, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Yuka Takahashi, Namiki Izumi. Efficacy and safety of switching therapy from tenofovir disoproxil fumarate to tenofovir alafenamide for hepatitis B virus infection. 2019 EASL 2019.04.12 Vienna

  22. Tsuchiya K, Watanabe S, Shirasaki T, Nishimura R, Katsukura N, Hibiya S, Okamoto R, Nakamura T, Watanabe M. TP53 mutation in human colonic organoids acquires resistance to in vitro long-term inflammation.. ECCO2019 2019.03.09 Copenhagen（Denmark）

  23. Takashi Nagaishi, Yudai Kojima, Daiki Yamada, Taro Watabe, Naoya Tsugawa, Nisha Jose, Michio Onizawa, Mamoru Watanabe.. APL expression is downregulated in an animal model of chronic colitis.. ECCO2019 2019.03.08 Copenhagen（Denmark）

  24. Shuji Hibiya, Kiichiro Tsuchiya, Ryu Nishimura, Tomoaki Shirasaki, Sho Watanabe, Nobuhiro Katsukura, Tetsuya Nakamura, Mamoru Watanabe. Establishment of an in vitro system to evaluate the therapeutic effect of the investigational drug on ulcerative colitis using human colonic organoids.. ECCO2019 2019.03.08 Copenhagen（Denmark）

  25. Kawamoto A, Nagata S, Anzai S, Takahashi J, Kawai M, Hama M, Nogawa D, Yamamoto K, Kuno R, Suzuki K, Shimizu H, Hiraguri Y, Yui S, Oshima S, Tsuchiya K, Nakamura T, Ohtsuka K, Kitagawa M, Okamoto R, Watanabe M. Synergy of Notch signalling and TNF-α in the inflamed intestinal epithelia of IBD patients leads to up-regulation of UBD, a ubiquitin-like protein. ECCO2019 2019.03.08 Copenhagen（Denmark）

  26. Okamoto R, Watanabe M. 【Session 2: Clinical assessment and therapeutic modulation of intestinal regeneration in IBD】Epithelial transplantation to facilitate mucosal healing. ECCO2019 2019.03.07 Copenhagen（Denmark）

  27. Suzuki K, Shimizu H, Kawai M, Takahashi J, Anzai S, Kawamoto A, Nagata S, Hiraguri Y, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Okamoto R, Watanabe M . UC-related and segment-specific properties of patientderived colonic organoids. ECCO2019 2019.03.07 Copenhagen（Denmark）

  28. Shigeru Oshima, Yoichi Nibe, Akiko Tamura, Hiroki Matsuda, Emi Aonuma, Kana Otsubo, Mamoru Watanabe. K33-linked polyubiquitin is recruited by SQSTM1/p62. Keystone Symposia: Autophagy(B2) 2019.02.19 New Mexico（USA）

  1. Yudai Kojima, Takashi Nagaishi, Taro Watabe, Daiki Yamada, Naoya Tsugawa, Nisha Jose, Akinori Hosoya, Masahiro Shimizu, Michio Onizawa, Mamoru Watanabe. Downregulated APL expression in T cells in the setting of chronic colitis. 第47回日本免疫学会学術集会 2018.12.10 福岡国際会議場（福岡県福岡市）

  2. Asahina Y. Increased risk of HCC following DAA: fact or fiction? / Follow up strategy after SVR in chronic hepatitis C. Asian Pacific Digestive Week 2018 2018.11.16 Seoul（Korea）

  3. Nakagawa M, Asahina Y, Kawai-Kitahata F, Murakawa M, Nitta S, Itsui Y, Azuma S, Kakinuma S, Tomita M, Watanabe M. Post-Treatment M2BPGi Level Is Useful for Predicting HCC Occurrence and Recurrence after Viral Eradication in Chronic Hepatitis C Patients. AASLD, The Liver Meeting 2018 2018.11.10 San Francisco (USA）

  4. Nitta S, Kato T, Tuchiya J, Sato A, Tsunoda T, Miyoshi M, Inoue- Shinomiya E, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Kakinuma S, Asahina Y. The Characteristic and the Anti-HCV Reagents Susceptibility Analysis of NS5A Resistance-Associated Substitutions (RAS) Detected after Daa Treatment Failure Patients. AASLD, The Liver Meeting 2018 2018.11.10 San Francisco (USA）

  5. Asahina Y, Kawai-Kitahata F, Murakawa M, Nitta S, Nakagawa M, Kakinuma S, Watanabe M. Gene Mutational Profile and Viral Integration in Hepatocellular Carcinoma with or without HBV/HCV Suppression. AASLD, The Liver Meeting 2018 2018.11.10 San Francisco（USA）

  6. Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K. Naruse, Mamoru Watanabe, Akinori Kimura. Mice overexpressing MKL1 in macrophages experience fulminant colitis. UEGW 2018 2018.10.22 Vienna（Austria）

  7. Yudai Kojima, Takashi Nagaishi, Taro Watabe, Naoya Tsugawa, Nisha Jose, Daiki Yamada, Akinori Hosoya, Takahiro Adachi, Mamoru Watanabe. B cell-mediated ileocecal immune response is activated in the early phase of colitis development. UEGW 2018 2018.10.22 Vienna（Austria）

  8. Kuwabara K, Ishibashi F, Kawamoto A, Anzai S, Takahashi J, Nagata S, Shimizu H, Yui S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R. Long-lived secretory cells residing in the Mouse proximal colon serve as reserve stem cells Under DNA damage-induced mucosal injury. UEGW 2018 2018.10.22 Vienna（Austria）

  9. Watanabe S, Tsuchiya K, Shirasaki T, Hibiya S, Nishimura S, Katsukura N, Oshima S, Okamoto R, Tetsuya N, Watanabe M. Tp53 mutation enhances cell proliferation and stemness in human colon epithelial organoids and promotes a resistance against long-term inflammation. UEGW 2018 2018.10.22 Vienna（Austria）

  10. Hibiya S, Tsuchiya K, Nishimura R, Shirasaki T, Watanabe S, Katsukura N, Okamoto R, Nakamura T, Watanabe M. Lesion-specific gene expression in the Epithelial cells of Crohn’s disease by comparing Small intestinal organoids from active and inactive Lesion in the same patient. UEGW 2018 2018.10.22 Vienna（Austria）

  11. Ishibashi F, Kuwabara K, Kawamoto A, Anzai S, Takahashi J, Nagata S, Shimizu H, Yui S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R. Ectopic expression of reg3a in the mice distal Colon is mediated by interactions between notch and Il-22 signaling pathways, and promotes tissue repair By the augmentation of EGFR signaling. UEGW 2018 2018.10.22 Vienna（Austria）

  12. Kazuo Ohtsuka . State of the art for single balloon enteroscopy; Secrets of troubleshooting during insertion and therapeutic management. The6th GSTEC2018 2018.10.13 Seoul (Korea)

  13. Nitta S, Kato T, Tuchiya J, Shinomiya-Inoue E, Sato A, Tsunoda T, Miyoshi M, Kitahata-Kawai F, Murakawa M, Istui Y, Azuma S, Nakagawa M, Kakinuma S, Asahina Y. The in vitro analysis of NS5A resistance-associated substitutions (RAS) observed in DAA treatment failure patients. 25th International Symposium on Hepatitis C Virus and Related Viruses 2018.10.09 Dublin（Ireland）

  14. Suzuki K, Takahashi J, Hiraguri Y, Yui S, Shimizu H, Tsuchiya K, Nakamura T, Ohtsuka K, Okamoto R, Watanabe M. . Crohn’s disease patient-derived small intestinal organoids reveal diseasestatus related modification of stem cell properties.. 5th TERMIS World Congress 2018 2018.09.07 Kyoto（JAPAN）

  15. Okamoto R, Watanabe M. Regenerative medicine for the treatment of inflammatory bowel disease. 5th TERMIS World Congress 2018 2018.09.07 Kyoto（JAPAN）

  16. Takenaka K, Ohtsuka K, Fujii T, Nagahori M, Saito E, Motobayashi M, Suzuki K, Watanabe M. Small bowel mucosal healing of Crohn’s disease treated with anti-TNF antibodies. FALKsymposium 2018.09.07 Kyoto（JAPAN）

  17. Suzuki K, Murano T, Hiraguri Y, Takahashi J, Shimizu H,Anzai S, Kuwabara K, Kawamoto A, Ishibashi F, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Watanabe M, Okamoto R.. Crohn’s disease patient-derived small intestinal organoids reveal disease-status related modification of stem cell properties.. 5th TERMIS World Congress 2018 2018.09.06 Kyoto（JAPAN）

  18. Kazuo Ohtsuka. Immunologocal Implication in the Development of IBD Medications. TASSID 3rd Academic Meeting of 2018 2018.09.01 Taipei（Taiwan）

  19. Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K. Naruse, Mamoru Watanabe, Akinori Kimura. Overexpression of MKL1 in Macrophages leads to the development of murine colitis. MICS 2018 2018.07.19 Oxford（UK）

  20. Saito E, Suzuki K, Shimizu H, Motobayashi M, Takenaka K, Onizawa M, Fujii T, Nagahori M, Ohtsuka K, Watanabe M. The clinical efficacy of switching cases between Infliximab(IFX) andAdalimumab(ADA) in patients with ulcerative colitis. AOCC2018 2018.06.22 Shanghai （China）

  21. Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K. Naruse, Mamoru Watanabe, Akinori Kimura. Mice overexpressing MKL1 in macrophages are susceptible to DSS-induced colitis. FOCIS 2018 2018.06.22 San Francisco (USA）

  22. Yasuhiro Nemoto. Colonic regulatory T Cells function during the ulcerative colitis. AOCC2018 2018.06.22 Shanghai（China）

  23. Ishibashi F, Shimizu H, Kawamoto A, Suzuki K, Anzai S, Kuwabara K, Takahashi J, Nagata S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R. Mouse colonic secretory cells de-differentiate into intestinal stem cells and promote mucosal repair through activation of NF-KB signalin. ISSCR2018 2018.06.20 Melbourne

  24. Takashi Nagaishi, Taro Watabe, Tsugawa, Yudai Kojima, Nisha Jose, Daiki Yamada, Takahiro Adachi, Mamoru Watanabe. Analysis of cecal immune response in a murine model of colitis using intravital imaging. FOCIS 2018 2018.06.20 San Francisco (USA）

  25. Jianbo An, Takashi Nagaishi, Taro Watabe, Taeko K. Naruse, Mamoru Watanabe, Akinori Kimura. Mice overexpressing MKL1 in macrophages are susceptible to the development of colitis. DDW 2018 2018.06.05 Washington D.C (USA）

  26. Taro Watabe, Takashi Nagaishi, Naoya Tsugawa, Yudai Kojima, Nisha Jose, Akinori Hosoya, Takahiro Adachi, Mamoru Watanabe. Analysis of ileocecal immune response in an animal model of colitis using intra-vital imaging. DDW 2018 2018.06.05 Washington D.C (USA）

  27. Shirasaki T, Tsuchiya K, Nishimura R, Watanabe S, Hibiya S, Katsukura N, Okamoto R, Nakamura T, Watanabe M.. Identification of lesion-specific epithelial function of ulcerative colitis by comparing colonic organoids from lesion and non-lesion parts of same patients.. DDW2018 2018.06.05 Washington D.C (USA）

  28. Hibiya S, Tsuchiya K, Watanabe S, Nishimura R, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M. Human colonic organoid treated with inflammatory factors might mimic the pathophysiology of epithelial cells in ulcerative colitis. DDW2018 2018.06.05 Washington D.C (USA）

  29. Suzuki K, Kuwabara K, Takahashi J, Anzai S, Kuno R, Kawamoto A, Ishibashi F, Nagata S, Hiraguri Y, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Okamoto R, Watanabe M.. Single-cell level analysis of organoids derived from CD patients reveals disease-status related modifications of small intestinal stem cells. DDW2018 2018.06.04 Washington D.C (USA）

  30. Ohtsuka K, Takenaka K, Suzuki K, Fujii T, Nagahori M, Matsuoka K, Saito E, Katsukura N, Fukuda M, Araki A, Watanabe M. Usefulness of single-balloon enteroscopy: from a single center 990 experiences. DDW2018 2018.06.03 Washington D.C (USA）

  31. Shiro Yui,Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Fetalization of colonic epithelium medicated by YAP/TAZ links ECM remodeling to tissue regeneration. 16th Stem Cell Research Symposium 2018.06.02 Hyakunenn-Koudou, Kyushu University, Fukuoka（Japan）

  32. Shiro Yui, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Fetalization of colonic epithelium medicated by YAP/TAZ links ECM remodeling to tissue regeneration. GI Research Academy 2018 2018.05.25 Tokyo (Japan)

  33. Fukiko Kawai-Kitahata. Difference of gene mutational profile among viral- and non-viral HCC with or without prior HBV infection: Results of comprehensive deep sequencing analyses of cancer genes and HBV/A AV integration. . EASL, The International Liver Congress 2018 2018.04.14 Paris(France)

  34. Asahina Y, Kakinuma S . HBV reactivation and changes in interferon-stimulated gene expression during treatment of direct-acting antivirals for HCV: Analyses in a novel in vitro model for HBV-HCV coinfection using human induced pluripotent stem cell-derived hepatic cells . EASL, The International Liver Congress 2018 2018.04.14 Paris（France）

  35. Ohtsuka K. Live demonstrations. (Single-balloon Endoscopy). Endoscopy 2018 2018.04.08 Kuala Lumpur（Malaysia）

  36. Ohtsuka K. Live demonstrations. (Single-balloon Endoscopy). Endoscopy 2018 2018.04.07 Kuala Lumpur（Malaysia）

  37. Ohtsuka K. Balloon-assisted Endoscopy. Tips and Trick. Endoscopy 2018 2018.04.07 Kuala Lumpur（Malaysia）

  38. Ohtsuka K. Tips of Enteroscopy -Single Balloon Endoscopy-. Taiwan Association for the Study of Small Intestinal Diseases (TASSID) Annual Meeting 2018 2018.03.25 Taipei（Taiwan）

  39. Ohtsuka K. Small Bowel Bleeding-Japan experience. Taiwan Association for the Study of Small Intestinal Diseases (TASSID) Annual Meeting 2018 2018.03.24 Taipei（Taiwan）

  40. Asahina Y, Liu CJ, Gane E, Itoh Y, Kawada N, Ueno Y, Wang CY, Llewellyn J, Osinusi A, Svarovskaia J, Mo H, Crans G, Chuang WL, Chen PJ, Enomoto N. Ledipasvir/Sofosbuvir All-oral Regimen for Patients with Chronic Hepatitis C Genotype 2 Infection: Integrated Analysis of Three Clinical Studies. 27th Annual Conference of the Asian Pacific Association for the Study of the Liver 2018.03.15 Dehli（India）

  41. Hibiya S, Tsuchiya K, Watanabe S, Nishimura R, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M. Establishment of in vitro human model for Ulcerative Colitis by using human colon organoid culture. 13th Congress of ECCO 2018.02.16 Vienna（Austria）

  42. Nishimura R, Tsuchiya K, Shirasaki T, Watanabe S, Hibiya S, Okamoto R, Nakamura T, Watanabe M.. The identification of lesion-specific gene expression in intestinal epithelial cells of Ulcerative Colitis by comparing colonic organoids from lesion and non-lesion parts of same patients.. The 13th Congress of ECCO 2018.02.16 Vienna

  43. Matsuda H, Nibe Y, Aonuma E, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Nakada S, Watanabe M, Oshima S. K33-linked polyubiquitin is recruited by SQSTM1/p62.. Keystone Symposia - Ubiquitin Signaling (A8) 2018.01.30 Tahoe(USA)

  44. Nibe Y, Matsuda H, Aonuma E, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Nakada S, Mamoru Watanabe M, Oshima S. Novel polyubiquitin imaging system, PolyUb-FC, visualized atypical polyubiquitin chain in living cells.. Keystone Symposia - Ubiquitin Signaling (A8) 2018.01.30 Tahoe(USA)

  45. Otsubo K, Maeyashiki C, Aonuma E, Matsuda H, Nibe Y, Kobayashi M, Matsuzawa Y, Watanabe M, Oshima S. Long-chain fatty acid regulates autophagy and polyubiquitination in intestinal epithelial cells. Keystone Symposia - Ubiquitin Signaling (A8) 2018.01.30 Tahoe(USA)

  46. Aonuma E, Nibe Y, Matsuda H, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Watanabe M, Oshima S. Necroptosis stimulation regulates SQSTM1/p62-LC3 complex formation and polyubiquitination. Keystone Symposia - Ubiquitin Signaling (A8) 2018.01.29 Tahoe(USA)

  47. Asahina Y. Host genome mutations and HBV integration in HCC patients with HBV infection. 36th US-Japan Hepatitis Panel Meeting 2018.01.10 Shenzhen（China）

  1. Tsugawa N, Nagaishi T, Watabe T, Hosoya A, Jose N, Kojima Y, Yoshikawa S, Karasuyama H, Adachi T, Watanabe M. Verification of immunoglobulin A regulation of mucosal microflora and homeostasis. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Miyagi (Japan)

  2. Watabe T, Nagaishi T, Hosoya A, Jose N, Tsugawa N, Kojima Y, Yoshikawa S, Karasuyama H, Adachi T, Watanabe M . Analysis of ileocecal immune response in an experimental colitis model using intra-vital imaging. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Miyagi (Japan)

  3. 朝比奈靖浩. Gap between real world data and the clinical trial with DAA for HCV. TASL2017 2017.12.10 台湾

  4. 朝比奈靖浩. Occurrence and recurrence of hepatocellular carcinoma (HCC) in HCV patients treated with direct acting antiviral agents.. KDDW2017 2017.11.23 Seoul (Korea)

  5. Chiba A, Nagaishi T, Miyake S. MAIT cells exacerbate the disease course of oxazolone-induced colitis. CD1-MR1 2017 2017.11.05 California (USA)

  6. Fujii T, Kitazume Y, Takenaka K, Kimura M, Saito E, Matsuoka K, Nagahori M, Ohtsuka K, Watanabe M. Simplified MR enterocolonography Classification Based on Endoscopic Findings for Activity Assessment of Crohn’s Disease. UEGW2017 2017.11.01 Barcelona(Spain)

  7. S. Watanabe K. Tsuchiya T. Shirasaki S. Hibiya S. Ooshima T. Nakamura R. Nishimura R. Okamoto M. Watanabe. TP53 mutation acquires higher malignant potential in human colon cancer cells. UEGW2017 (欧州消化器病学会週間2017） 2017.11.01 Barcelona(Spain)

  8. Kawamoto A, Ito G, Nakata T, Fujii S, Suzuki K, Ishibashi F, Shimizu H, Nagata S, Anzai S, Kuno R, Kuwabara K, Kawai M, Takahashi J, Hama M, Tsuchiya K, Nakamura T, Okamoto R, Watanabe M. The ubiquitin-like protein ubiquitin d is up-regulated by synergy of notch and pro-inflammatory cytokines in the inflamed intestinal epithelia of ibd patients.. UEGW2017 2017.11.01 Barcelona(Spain)

  9. F. Ishibashi H. Shimizu A. Kawamoto G. Ito T. Nakata S. Fujii K. Suzuki R. Kuno S. Anzai K. Kuwabara M. Kawai J. Takahashi M. Hama S. Nagata K. Tsuchiya T. Nakamura R. Okamoto M. Watanabe. Reprogrammed Atoh1+ intestinal epithelial cells contribute to regenerate damaged colonic mucosa in DSS-induced colitis. UEGW2017 (欧州消化器病学会週間2017） 2017.11.01 Barcelona(Spain)

  10. Tanaka H, Kamata N, Yamada A, Fujii T, Endo K, Yoshino T, Bamba S, Sugaya T, Kawaguchi T, Ishii M, Shinzaki S, Toya Y, Yanai Y, Yokoyama Y, Umeno J, Okada T, Kobayashi T, Nojima M, Hibi T. Usefulness of combination therapy with adalimumab and immunomodulators in patients with crohn’s disease: a large, multi-centre cohort study. UEGW2017 2017.10.31 Barcelona(Spain)

  11. N. Tsugawa T. Nagaishi T. Watabe N. Jose A. Hosoya Y. Kojima T. Adachi R. Blumberg M. Watanabe. Verification of immunoglobulin a regulation of microflora and protection of intestinal mucosa. UEGW2017 (欧州消化器病学会週間2017） 2017.10.31 Barcelona(Spain)

  12. Shinzaki S, Fujii T, Bamba S, Kobayashi T, Tanaka T, Yoshino T, Yamada A, Kamata N, Hibi T. Safety and efficacy of Helicobacter pylori eradication in patients with inflammatory bowel disease. UEGW2017 2017.10.31 Barcelona(Spain)

  13. Takenaka K, Ohtsuka K, Kitazume Y, Fujii T, Matsuoka K, Kimura M, Nagahori M, Watanabe M. Utility of Magnetic Resonance Evaluation for Small Bowel Endoscopic Healing in Patients with Crohn’s Disease. UEGW2017 2017.10.30 Barcelona(Spain)

  14. Kaneko S, Kakinuma S, Asahina Y, Kamiya A, Miyoshi M, Tsunoda T, Inoue-Shinomiya E, Nitta S, Sato A, Asano Y, Nagata H, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Watanabe M. A novel culture model for coinfection of hepatitis B and hepatitis C viruses using human induced pluripotent stem cell–derived hepatic cells for analyses of changes in host-innate immune responses . AASLD The Liver Meeting 2017 2017.10.22 Washington DC

  15. Nakagawa M, Asahina Y, Nagata H, Kaneko S, Kawai-Kitahata F, Murakawa M, Nitta S, Itsui Y, Azuma S, Kakinuma S, Tanaka Y, Watanabe M. Evaluation of an early occurrence and recurrence of hepatocellular carcinoma in chronic hepatitis C patients treated with All-Oral DAAs - propensity score-matched analysis of a prospective database -. AASLD, The Liver Meeting 2017 2017.10.22 Walter E. Washington Convention Center（Washington D.C, USA）

  16. Nitta S, Murakawa M, Kato T, Asahina Y.. The analysis of NS5A Resistance-Associated Substitutions (RAS): In vitro study of NS5A recombinant hepatitis C in infectious cell culture system for various RAS detected after treatment failure in chronic hepatitis C patients . AASLD The Liver Meeting 2017 2017.10.21 Walter E. Washington Convention Center（Washington D.C, USA）

  17. Miyako Murakawa, Yasuhiro Asahina, Mina Nakagawa, Sayuri Nitta, Fukiko Kawai-Kitahata, Hiroko Nagata, Syun Kaneko, Yu Asano, Masato Miyoshi, Tomoyuki Tsunoda, Emi Inoue-Shinomiya, Ayako Sato, Yasuhiro Itsui, Sei Kakinuma, Seishin Azuma, Mamoru Watanabe. On-treatment higher levels of alpha-fetoprotein and M2BPGi are associated with development of hepatocellular carcinoma during nucleos(t)ide analog therapy in patients with HBV chronic infection. AASLD, The Liver Meeting 2017 2017.10.21 Washington DC

  18. HCC with or without viral suppression and new predictive biomarkers.. Taiwan Digestive Diseases Week 2017 2017.10.01

  19. Azuma S, Asahina Y, Kakinuma S, Azuma K, Watanabe M.. Diabetic retinopathy as a risk factor associated with development of hepatocellular carcinoma in non-alcoholic fatty liver disease.. Asian Pacific Digestive Week 2017.10.01

  20. YOHEI FURUMOTO, AKIHIRO ARAKI, SAYURI NITTA, HIROKO NAGATA, KENTO TAKENAKA, KOUHEI SUZUKI, ERIKO OKADA, TAKAO HORIUCHI, MAMORU WATANABE. Report of successful rescue of disrupted capsafter rule endoscopy retention. Asian Pacific Digestive Week 2017.09.26 Hongkong

  21. Seishin Azuma, Yasuhiro Asahina, Sei Kakinuma, Keiko Azuma, Mamoru Watanabe. Diabetic retinopathy as a risk factor associated with development of hepatocellular carcinoma in non-alcoholic fatty liver disease. Asian Pacific Digestive Week 2017 2017.09.25 香港

  22. Takenaka K, Ohtsuka K, Kitazume Y, Matsuoka K, Fujii T, Nagahori M, Kimura M, Watanabe M. Magnetic resonance enterography for small bowel mucosal healing in patients with Crohn’s disease. APDW2017 2017.09.23 (Hong Kong)

  23. Nagaishi T, Watabe T, Jose N, Hosoya A, Kojima Y, Tsugawa N, Adachi T, Watanabe M. Deficiency of IgA Induces Microflora Alteration and Ileal Inflammation. ICMI 2017 2017.07.21 Washington DC (USA)

  24. Motobayashi M, Matsuoka K, Iwamoto F, Takenaka K, Fujii T, Nagahori M, Enomoto N, Ohtsuka K, Watanabe M. Correlation of Fecal Calprotectin Levels with Endoscopic Severity Evaluated with Balloon-assisted Endoscopy in Patients with Crohn’s Disease. . AOCC2017 2017.06.17 Seoul, Korea

  25. Toyonaga T, Kobayashi T, Kuronuma S, Takeuchi O, Nakano M, Saito E, Umeda S, Okabayashi S, Ozaki R, Hibi T . Patient-Reported outcome is more reliable than fecal calprotectin in detecting early response to remission induction treatment in ulcerative colities. AOCC2017 2017.06.17 Seoul (Korea)

  26. Hosoya A, Nagaishi T, Watabe T, Tsugawa N, Jose N, Kojima Y, Adachi T, Watanabe M. Verification of immunoglobulin A protection of intestinal mucosa from microflora. AOCC2017 2017.06.16 Seoul (Korea)

  27. Fujii T, Kitazume Y, Takenaka K, Kimura M, Matsuoka K, Nagahori M, Ohtsuka K, Watanabe M. The 5-point MR enterocolonography classification based on endoscopic findings for activity assessment of Crohn's disease. AOCC2017 2017.06.16 Seoul (Korea)

  28. Saito E, Kobayashi T, Ozaki R, Okabayashi S, Umeda S, Nakano M, Toyonaga T, Kuronuma S, Takeuchi O, Hibi T. Is inflliximab blood concentration measurement of patients with IBD useful for optimization?. AOCC2017 2017.06.16 Seoul (Korea)

  29. Okamoto R, Watanabe M. Stem cell-based therapies: Ready for clinical practise? . AOCC2017 2017.06.16 Seoul (Korea)

  30. Kawamoto A, Ito G, Nakata T, Fujii S, Suzuki K, Ishibashi F, Shimizu H, Tsuchiya K, Nakamura T, Okamoto R, Watanabe M. Synergy of Notch signaling and pro-inflammatory cytokines leads to up-regulation of UBD in the inflamed intestinal epithelia of IBD patients. The 5th Annual Meeting of Asian Organization for Crohn's and Colitis 2017.06.16 Seoul (Korea)

  31. Takenaka K, Ohtsuka K, Kitazume Y, Matsuoka K, Fujii T, Nagahori M, Kimura M, Watanabe M. Magnetic resonance evaluation for small bowel endoscopic remission in patients with crohn’s disease. AOCC2017 2017.06.15 Seoul (Korea)

  32. Nagaishi T, Watabe T, Jose N, Hosoya A, Kojima Y, Tsugawa N, Adachi T, Watanabe M. IgA Deficiency Induces Spontaneous Inflammation in the Ileum. FOCIS 2017 2017.06.14 Chicago (USA)

  33. Nibe Y, Oshima S, Aonuma E, Matsuda H, Otsubo K, Maeyashiki C, Kobayashia M, Matsuzawa Y , Nakada S, Watanabe M. Novel polyubiquitin imaging reveals that atypical polyubiquitin contribute to autophagy. GI research Academy 2017 2017.06.09 Tokyo (JAPAN)

  34. Otsubo K, Oshima S, Maeyashiki C, Aonuma E, Matsuda H, Kobayashi M, Yoichi Nibe Y, Matsuzawa Y, Watanabe M. HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells. The 8th International Symposium on Autophagy 2017.05.29 Nara (Japan)

  35. Nibe Y, Oshima S, Aonuma E, Matsuda H, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Nakada S, Watanabe M. Novel polyubiquitin imaging reveals that atypical polyubiquitin contribute to autophagy via p62. The 8th International Symposium on Autophagy 2017.05.29 Nara (Japan)

  36. Watabe T, Nagaishi T, Hosoya A, Jose N, Tokai A, Kojima Y, Adachi T, Watanabe M. The lack of secreted IgA spontaneously induces the mucosal inflammation specifically in the ileum. DDW 2017 2017.05.09 Chicago (USA)

  37. Kobayashi m, Oshima S, Maeyashiki C, Nibe Y, Otsubo K, Watanabe M. The Ubiquitin Hybrid Gene UBA52 Regulates Cell Cycle and Ubiquitination of Ribosome in Colon Cancer. DDW 2017 2017.05.09 Chicago (USA)

  38. Fumiaki Ishibashi, Hiromichi Shimizu, Toru Nakata, Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Sho Anzai, Reiko Kuno, Sayaka Nagata, Go Ito, Tatsuro Murano, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Mamoru Watanabe. Lineage tracing reveals contribution of atoh1+ cell-derived stem cells in the homeostasis, repair, and carcinogenesis of the intestinal epithelium. DDW2017 2017.05.09 Chicago(USA)

  39. Kawai-Kitahata F, Asahina Y, Kakinuma S, Murakawa M, Niita S, Nagata H, Kaneko S, Otani S, Miyoshi M, Tsunoda T, Sato A, Nakagawa M, Itsui Y, Azuma S, Tanaka S, Tanabe M, Maekawa S, Enomoto N, Watanabe M. Genetic differences in hepatocellular carcinoma among chronic persistent hepatitis B virus infection with or without viral suppression and prior hepatitis B virus infection. EASL The International Liver Congress 2017 2017.04.20 Amsterdam

  1. Kawamoto A, Nakata T, Fujii S, Suzuki K, Ishibashi F, Shimizu H, Tsuchiya K, Nakamura T, Okamoto R, Watanabe M. Notch signaling and TNF-α synergistically up-regulate stem cell-specific genes, OLFM4 and UBD, in the inflamed intestinal epithelia of IBD patients. 2016 Advances in Inflammatory Bowel Diseases, Crohn’s & Colitis Foundation of America's Clinical & Research Conference (CCFA) 2016.12.10 Orlando, Florida

  2. Kamei M, Chiba A, Nagaishi T, Haga K, Miyake S. MAIT cells exacerbate the disease course of oxazolone colitis.. 第45回日本免疫学会学術集会 2016.12.07 沖縄コンベンションセンター（沖縄県宜野湾市）

  3. Wai-Kay Seto , Yasuhiro Asahina , Cheng-Yuan Peng , Carol Stanciu , Djamal Abdurakhmanov , John F. Flaherty , Kyungpil Kim , Anuj Gaggar , Mani Subramanian, Fehmi Tabak, Tuan T. Nguyen, Henry Lik-Yuen Chan. Reduced Changes In Bone Mineral Density In CHB Patients Receiving Tenofovir Alfenamide (TAF) Com-pared With Tenofovir disoproxil fumarate. AASLD The Liver meeting 2016 2016.11.11 Boston（USA）

  4. Seto WK, Asahina Y, Peng CY, Stanciu C, Abdurakhmanov D, Flaherty JF, Kim K, Gaggar A, Subramanian M, Tabak F, Nguyen TT, Chan HLY.. Reduced Changes In Bone Mineral Density In CHB Patients Receiving Tenofovir Alfenamide (TAF) Compared With Tenofovir disoproxil fumarate.. 2016.11.11

  5. Shun Kaneko, Sei Kakinuma, Yasuhiro Asahina, Akihide Kamiya, Masato Miyoshi, Tomoyuki Tsunoda, Sayuri Nitta, Ayako Sato, Yu Asano, Hiroko Nagata, Satoshi Otani, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Mamoru Watanabe. Genetically modified human induced pluripotent stem cell-derived hepatic progenitor-like cell lines as a model for interaction between hepatitis B virus and host cells. AASLD The Liver meeting 2016 2016.11.11 Boston（USA）

  6. Takenaka K, Ohtsuka K, Watanabe M. Magnetic resonance evaluation for small bowel strictures of Crohn’s disease: comparison with balloon enteroscopy. APDW2016 2016.11.05 Kobe convention center, KOBE（JAPAN）

  7. Watabe T, Nagaishi T, Tokai A, Jose N, Hosoya A, Kojima Y, Yamazaki M, Richard S. Blumberg, Watanabe M. CD66a regulation of BCR signaling in the activated B cells . APDW 2016 2016.11.04 神戸コンベンションセンター（兵庫県神戸市）

  8. Watabe　T, Nagaishi T, Suzuki M, Yamazaki M, Onizawa M, Jose N, Tokai A, Hosoya A, Kojima Y, Watanabe M. Type 2 TNF receptor signaling in colonic epithelia may be involved in the development of colitis-associated carcinogenesis. APDW 2016 2016.11.03 神戸コンベンションセンター（兵庫県神戸市）

  9. Tsuchiya K, Hibiya S, Fukushima K, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M. Atoh1 protein stabilization in colon tumor acquires the　morphological change to signet ring cell carcinoma with cancer stem cell enrichment. APDW2016 2016.11.03 Kobe convention center, KOBE（JAPAN）

  10. Fujii T, Takenaka K, Kitazume Y, Kimura M, Matsuoka K, Nagahori M, Ohtsuka K, Watanabe M. MR enterocolonography can detect small bowel strictures and predict surgery in patients with Crohn’s disease: Comparison with balloon enteroscopy. APDW2016 2016.11.03 Kobe convention center, KOBE（JAPAN）

  11. Asahina Y. 【International Session（Symposium）1】Genomics of hepatocellular carcinoma: Hepatitis virus infection and hepatocarcinogenesis. Chair . JDDW2016 2016.11.03 Kobe Cinvention Center（Kobe JAPAN）

  12. Asahina Y. Recent progress in anti-HCV therapy and challenges toward HCC eradication.. Academic Forum of Liver Disease in Northeast China and the Annual Convention for the Study of Liver Diseases in Jilin Province in 2016. 2016.10.29 Changchun（China）

  13. Hosoya A, Nagaishi T, Tokai A, Watabe T, Jose N, Kojima Y, Yamazaki M, Richard S. Blumberg, Watanabe M. CEACAM1 regulation of BCR signaling in the activated B cells. UEGW2016 2016.10.19 VIENNA

  14. Toshimitsu Fujii, Kento Takenaka, Maiko Kimura, Katsuyoshi Matsuoka, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe. MR enterocolonography evaluation for small bowel strictures in patients with Crohn’s disease: comparison with balloon enteroscopy. UEGW2016 2016.10.18 Vienna（Austria）

  15. Hibiya S, Tsuchiya K, Watanabe S, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M. Construction of in vitro model of ulcerative colitis using mouse primary colonic organoid.. UEGW2016 2016.10.18 Vienna（Austria）

  16. Yui S (招待講演). Dissecting the molecular and cellular mechanisms responsible for tissue repair in inflammatory bowel disease.. First international conference on tissue repair, regeneration, and fibrosis. 2016.09.23 Rhodes, Greece

  17. Nagaishi T, Tokai A, Watabe T, Jose N, Hosoya A, Yamazaki M, Blumberg RS, Watanabe M. BCR signaling in the activated B cells may be regulated by CEACAM1. Mucosal Immunology Course & Symposium (MICS）2016 2016.07.29 Toronto（Canada）

  18. Ohtsuka K, Takenaka K, Fujii T, Matsuoka K, Nagahori M, Kimura M, Fukuda M, Katsukura N, Watanabe M. Mucosal healing improves prognosis of endoscopic balloon dilatatiion for small intestinal strictures of Crohn's disease. AOCC2016 2016.07.09 Kyoto

  19. Taro Watabe, Takashi Nagaishi, Arisa Tokai, Akinori Hosoya, Nisha Jose, Yudai Kojima, Motomi Yamazaki, Richard S. Blumberg, Mamoru Watanabe. BCR signaling in the activated B cells may be regulated by CD66a. AOCC2016 2016.07.08 Kyoto International Conference Center, Kyoto（JAPAN）

  20. Minami Hama, Ayumi Hayashi, Tomohiro Mizutani, Satoru Fujii, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Ken Watanabe, Norio Shimizu, Ryuichi Okamoto, Mamoru Watanabe. Prevalence of viral DNA in the mucosal tissue and cultured organoids of inflammatory bowel disease patients.. AOCC2016 2016.07.08 Kyoto International Conference Center, Kyoto（JAPAN）

  21. Shuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Mouse colonic organoid acquires wnt-independent survival property after long-term inflammation.. AOCC2016 2016.07.08 Kyoto International Conference Center, Kyoto（JAPAN）

  22. Toshimitsu Fujii, Kento Takenaka, Maiko Kimura, Katsuyoshi Matsuoka, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe. The evaluation for small bowel strictures on MR enterocolonography in patients with Crohn’s disease. AOCC2016 2016.07.08 Kyoto International Conference Center, Kyoto（JAPAN）

  23. Kiichiro Tsuchiya, Shuji Hibiya, Keita Fukushima, Tomoaki Shirasaki, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Atoh1 protein stabilization in colon tumor acquires the phenotype of signet ring cell carcinoma with cancer stem cell enrichment.. AOCC2016 2016.07.08 Kyoto International Conference Center, Kyoto（JAPAN）

  24. Kawamoto A, Ito G, Nakata T, Fujii S, Suzuki K, Ishibashi F, Shimizu H, Tsuchiya K, Nakamura T, Okamoto R, Watanabe M. OLFM4 and UBD are up-regulated in the inflamed intestinal epithelia of IBD patients by synergy of Notch signaling and TNF-α. AOCC2016 2016.07.07 Kyoto International Conference Center, Kyoto（JAPAN）

  25. Tomoaki Shirasaki, Kiichiro Tsuchiya, Shuji Hibiya, Ryu Nishimura, Keita Fukushima, Sho Watanabe, Ryuichi Okamoto, Tetsuya Nakamura and Mamoru Watanabe. Stimulation with the ligands of Toll like receptors in primary human organoids.. AOCC2016 2016.07.07 Kyoto International Conference Center, Kyoto（JAPAN）

  26. Kento Takenaka, Kazuo Ohtsuka, Yoshio Kitazume, Masakazu Nagahori, Katsuyoshi Matsuoka, Toshimitsu Fujii, Maiko Kimura, Tomoyuki Fujioka, Mamoru Watanabe. Enteroscopic and MR findings of small bowel in Crohn’s disease. AOCC2016 2016.07.07 Kyoto International Conference Center, Kyoto（JAPAN）

  27. Maiko Kimura, Katsuyoshi Matsuoka, Eiko Saito, Toshimitsu Fujii, Kento Takenaka, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe. Salvage therapy for corticosteroid-refractory ulcerative colitis patients. AOCC2016 2016.07.07 Kyoto International Conference Center, Kyoto（JAPAN）

  28. Ami Kawamoto, Go Ito, Toru Nakata, Satoru Fujii, Kohei Suzuki, Fumiaki Ishibashi, Hiromichi Shimizu, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Mamoru Watanabe. OLFM4 and UBD are up-regulated in the inflamed intestinal epithelia of IBD patients by synergy of Notch signaling and TNF-α. AOCC2016 2016.07.07 Kyoto International Conference Center, Kyoto （JAPAN）

  29. Kazuo Ohtsuka, Kento Takenaka, Toshimitsu Fujii, Katsuyoshi Matsuoka, Masakazu Nagahori, Maiko Kimura, Masayoshi Fukuda, Nobuhiro Katsukura, Mamoru Watanabe. Mucosal healing improves prognosis of endoscopic balloon dilatation for small intestinal strictures of Crohn’s disease. AOCC2016 2016.07.07 Kyoto

  30. Tokai A, Nagaishi T, Watabe T, Jose N, Hosoya A, Yamazaki M, Onizawa M, Richard S. Blumberg, Watanabe M . Activated B cell receptor signaling may be regulated by CEACAM1. FOCIS 2016 2016.06.23 Boston

  31. Asahina Y. Hepatocarcinogenesis after hepatitis C viral eradication.. The 10th APASL Single Topic Conference 2016.06.08 Kaoshiung（Taiwan）

  32. Yui S, Guiu J, Schweigher P, Hanson G, Jensen K. Regional identity of cellular materials dictates the clinical potential in regenerative medicine for inflammatory bowel disease. . Stem Cell Niche conference, Development and Disease 2016.05.26 Favrholm, Denmark

  33. Masanori Kobayashi, Shigeru Oshima, Yoishi Nibe, Chiaki Maeyashiki, Mamoru Watanabe. UBA52, ubiquitin hybrid ribisomal protein, regulates NF-κB signaling in colon cancer. DDW2016 2016.05.24 San Diego

  34. Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Toru Nakata, Go Ito, Hiromichi Shimizu, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Ohtsuka, Ryuichi Okamoto, Mamoru Watanabe. In Vitro organoid model reveals PGF2 as a Robust Mediator of chloride & water secretion bt human intestinal epithelial cells. DDW2016 2016.05.23 San Diego（USA）

  35. Kazuo Ohtsuka, Kento Takenaka, Toshimitsu Fujii, Katsuyoshi Matsuoka, Masakazu Nagahori, Kengo Nozaki, Masayoshi Fukuda, Mamoru Watanabe. Mucosal Healing is imoietant for better outcomes of endosdopic balloon dilatation for smakk intestinal stricture of crohn's disease. DDW2016 2016.05.23 San Diego

  36. Chiaki Maeyashiki, Shigeru Oshima, Yoishi Nibe, Masanori Kobayashi, Mamoru Watanabe. Indentification of autophagic regulators as therapeutic targets in intestinal epithelial cells. DDW2016 2016.05.23 San Diego（USA）

  37. Kiichiro Tsuchiya, Shuji Hibiya, Keita Fukushima, Tomoaki Shirasaki, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. ATOH1 Protein stabillzation in tumor acquires the morphological change to signet ring cell enrichment in colon cancer. DDW2016 2016.05.22 San Diego（USA）

  38. Toru Nakata, Go Ito, Hiromichi Shimizu, Satoru Fujii, Kohei Suzuki, Fumiaki Ishibashi, Ami Kawamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Ryuichi Okamoto, Mamoru Watanabe. Jagged1 is indispensable for the maintenance of tumor stem cell niche in APC-Deficient intestinal adenomas. DDW2016 2016.05.22 San Diego（USA）

  39. Stuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Construction of in vitro model for inflammatory bowel disease using primary colonic organoid. DDW2016 2016.05.21 San Diego（USA）

  40. Kohei Suzuki, Satoru Fujii, Ami Kawamoto, Fumiaki Ishibashi, Toru Nakata, Go Ito, Hiromichi Shimizu, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Otsuka, Ryuichi Okamoto, Mamoru Watanabe. Single-cell level analysis reveals hoterogeneous expression of stem-cell specific genes in human small intestinal organoids. DDW2016 2016.05.21 San Diego（USA）

  41. Takashi Nagaishi, Arisa Tokai, Taro Watabe, Nisha Jose, Akinori Hosoya, Motomi Yamazaki, Richard S.Blumberg, Mamoru Watanabe. CEACAM1 may resulate BCR signaling in the activated B cells. DDW2016 2016.05.21 San Diego（USA）

  42. Kazuo Ohtsuka, Kento Takenaka, Mamoru Watanabe. 【Session 3: Imaging for follow up of IBD】Assessment of small intestinal lesions of Crohn’s disease. 第102回日本消化器病学会総会_The 5th International Forum 2016.04.21 Tokyo

  43. Masanori Kobayashi, Shigeru Oshima, Yoishi Nibe, Chiaki Maeyashiki, Mamoru Watanabe. UBA52, ubiquitin hybrid protein, regulates NF κB signaling. 第102回日本消化器病学会総会_The 5th International Forum 2016.04.21 Tokyo

  44. Ryuichi Okamoto, Mamoru Watanabe. 【Session 4: Novel therapeutic approaches and emerging issues in IBD】Application of regenerative medicine for the treatment of inflammatory bowel disease. The 102nd JSGE-The 5th International Forum 2016.04.21 Tokyo（JAPAN）

  45. Kentaro Takenaka, Kazuo Ohtsuka, Yoshio Kitazume, Masakazu Nagahori, Katsuyoshi Matsuoka, Toshimitsu Fujii, Maiko Kimura, Tomoyuki Fujioka Mamoru Watanabe. Magnetic resonance evaluation for deep small intestinal strictures in patients with Crohn’s disease. 第102回日本消化器病学会総会_The 5th International Forum 2016.04.21 京王プラザホテル（東京都新宿区）

  46. Takenaka K, Ohtsuka K, Kitazume Y, Nagahori M, Matsuoka K, Fujii T, Kimura M, Fujioka T, Watanabe M. Enteroscopic and MR findings of small intestine in Crohn’s disease.. 7th APTC 2016.04.20 京王プラザホテル（東京都新宿区）

  47. Kaneko S, Kakinuma S, Asahina Y, Kamiya A, Nitta S, Tsunoda T, Miyoshi M, Asano Y, Nagata H , Goto F, Otani S, Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Watanabe M. A new model for studying interaction between hepatitis B virus and host cells derived from human induced pluripotent stem cells.. EASL The International Liver Congress 2016 2016.04.14 Barcelona（Spain）

  48. K. Matsuoka, E. Saito, T. Fujii, K. Takenaka, F. Iwamoto, M. Kimura, M. Nagahori, K. Ohtsuka, M. Watanabe. Efficacy and safety of sequential rescue therapy with infliximab and tacrolimus in patients with corticosteroid-refractory Ulcerative Colitis. 11th Congress of ECCO - European Crohn‘s and Colitis Organisation 2016.03.19 Amsterdam（Nederland）

  49. Kaneko S, Kakinuma S, Asahina Y, Kamiya A, Nitta S, Tsunoda T, Miyoshi M, Asano Y, Nagata H , Goto F, Otani S, Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Watanabe M. A Model for Interaction between HBV and Host Cells Derived from Human Induced Pluripotent Stem Cells.. The 25th Asian Pacific Association for the Study of the Liver 2016.02.22 International Convention Center Pamir, Tokyo（JAPAN）

  50. Asahina Y. 【HCV 5】Chair. The 25th Asian Pacific Association for the Study of the Liver 2016.02.22 International Convention Center Pamir, Tokyo（JAPAN）

  51. Asahina Y. 【HCV 2】Chair . The 25th Asian Pacific Association for the Study of the Liver 2016.02.22 International Convention Center Pamir, Tokyo（JAPAN）

  52. Nagata H, Sakurai Y, Nakagawa M, Kakinuma S, Azuma S, Murakawa M, Nitta S, Itsui Y, Asahina Y, Watanabe M. Serial changes in M2BPGi levels as predictors of fibrosis and HCC in chronic hepatitis C. The 25th Asian Pacific Association for the Study of the Liver 2016.02.22 International Convention Center Pamir, Tokyo（JAPAN）

  53. Kawai-Kitahata F, Asahina Y, Tanaka S, Kakinuma S, Murakawa M, Nitta S, Otani S, Goto F, Nagata H, Kaneko S, Asano Y, Miyoshi M, Tsunoda T, Azuma S, Itsui Y, Nakagawa M, Tanabe M, Maekawa S, Enomoto N, Watanabe M. Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma. The 25th Asian Pacific Association for the Study of the Liver 2016.02.22 International Convention Center Pamir, Tokyo（JAPAN）

  54. Nitta S, Asahina Y, Wakita T, Kato T.. In vitro characterization and drug sensitivity analysis for HCV NS5A resistance-associated variants.. The 25th Asian Pacific Association for the Study of the Liver 2016.02.22 International Convention Center Pamir, Tokyo（JAPAN）

  1. Satoru Fujii, Ryuichi Okamoto, Toru Nakata, Kohei Suzuki, Fumiaki Ishibashi, Ami Kawamoto,Sayaka Ohashi Segawa, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Establishment of a 3D cell culture-based screening platform to identify natural products that can regulate transepithelial water transport of the human gastrointestinal tract. Pacifichem2015 2015.12.17 Hawaii

  2. Watabe T, Nagaishi T, Suzuki M, Yamazaki M, Onizawa M, Nisha J, Tokai A, Hosoya A, Kawai R, Watanabe M. APL may regulate chemokine production by macrophages in the setting of colitis. 第44回日本免疫学会学術集会 2015.11.20 札幌コンベンションセンター(北海道　札幌市）

  3. Shun Kaneko, Sei Kakinuma, Yasuhiro Asahina, Akihide Kamiya, Sayuri Nitta, Tomoyuki Tsunoda, Masato Miyoshi, Hiroko Nagata, Fumio Goto, Satoshi Otani, Miyako Murakawa, Fukiko Kawai-Kitahata, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Mamoru Watanabe. Human induced pluripotent stem cell-derived hepatic progenitor-like cells and hepatocyte-like cells as a model for interaction between hepatitis B virus and host cells. AASLD The Liver Meeting 2015 2015.11.16 San Francisco, CA

  4. Kawai-Kitahata F, Asahina Y, Tanaka S, Kakinuma S, Murakawa M, Nitta S, Watanabe T, Otani S, Goto F, Nagata H, Kaneko S, Azuma S, Itsui Y, Nakagawa M, Tanabe M, Maekawa S, Enomoto N, Watanabe M. Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features. AASLD The Liver Meeting 2015 2015.11.14 San Francisco, CA

  5. Sayuri Nitta, Yasuhiro Asahina, Takaji Wakita, Takanobu Kato. Effects of Resistance Mutations of NS5A Inhibitor on Viral Production and Susceptibility to Anti-HCV Reagents in Recombinant Hepatitis C Viruses with NS5A of Genotype 1b. AASLD The Liver Meeting 2015 2015.11.13 San Francisco, CA

  6. Miyako Murakawa, Yasuhiro Asahina, Fukiko Kawai-Kitahata, Hiroko Nagata, Syun Kaneko, Sayuri Nitta, Takako Watanabe, Yasuhiro Itsui, Mina Nakagawa, Sei Kakinuma, Sayuki Iijima, Yasuhito Tanaka, Mamoru Watanabe, Yujiro Tanaka. Expression of IFNλ4 in liver is closely associated with non-response to antiviral therapy through the regulation of basal expression of ISGs in chronic hepatitis C patients but not in hepatitis B patients. AASLD The Liver Meeting 2015 2015.11.13 San Francisco, CA

  7. Takako Watanabe, Yasuhiro Asahina, Mina Nakagawa, Sei Kakinuma, Yasuhiro Itsui, Hiroko Nagata, Miyako Murakawa, Fukiko Kawai-Kitahata, Mika Miura, Shinya Maekawa, Nobuyuki Enomoto, Mamoru Watanabe. Serial change of resistant associated variants during early phase of NS3/4A triple therapy and the final virological outcome: analyses by ultra-deep sequencing technology. AASLD The Liver Meeting 2015 2015.11.13 San Francisco, CA

  8. Hiroko Nagata, Yasuhiro Itsui, Fukiko Kawai-Kitahata, Shun Kaneko, Miyako Murakawa, Sayuri Nitta, Mina Nakagawa, Seishin Azuma, Sei Kakinuma, Yasuhiro Asahina. Variations of the host genome and interaction of hepatitis B viral X protein associated with hepatocarcinogenesis. AASLD The Liver Meeting 2015 2015.11.13 San Francisco, CA

  9. Tomoaki Shirasaki, Keita Fukushima, Kiichirou Tsuchiya, Shuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. TNF-α stabilizes atoh1 protein in colitis-associated colorectal cancer resulting in enhanced malignant potential. . UEGW2015 2015.10.28 Barcelona

  10. Taro Watabe, Takashi Nagaishi, Masahiro Suzuki, Motomi Yamazaki, Michio Onizawa, Nisha Jose, Arisa Tokai, Akinori Hosoya, Risa Kawai, Mamoru Totsuka, Mamoru Watanabe. Epithelial TNFR2 signaling in the setting of ibd may be involved in the development of colitis-associated carcinogenesis . UEGW2015 2015.10.28 Barcelona

  11. Kiichiro Tsuchiya, Ryohei Hayashi, Shuji Hibiya, Keita Fukushima, Nobukatsu Horita, Tomoaki Shirasaki, Mamoru Watanabe. Mapping biopsy of entire small intestine revealed specific gene expression in crohn's disease . UEGW2015 2015.10.27 Barcelona

  12. Shuji Hibiya, Kiichiro Tsuchiya, Tomoaki Shirasaki, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima , Ryuichi Okamoto, Tetsuya Nakamura,Mamoru Watanabe. Contiuous stimulation with cytokines leads to irreversible activation of NF-γb signaling in colonic epithelial cells by organoid culture . UEGW2015 2015.10.27 Barcelona

  13. Kiichiro Tsuchiya, Shuji Hibiya, Mamoru Watanabe. Acquisition of enhanced malignant potential in inflammation associated colon cancer. The 74th Annual Meeting of the Japanese Cancer Association 2015.10.09 Nagoya

  14. Taro Watabe, Takashi Nagaishi, Masahiro Suzuki, Motomi Yamazaki, Nisha Jose, Arisa Tokai, Akinori Hosoya, . Type 2 TNF receptor signaling in the epithelia may be involved　in the development of colitis-associated carcinogenesis. The 74th Annual Meeting of the Japanese Cancer Association 2015.10.08 Nagoya

  15. Hosoya A,Nagaishi T,Watabe T,Suzuki M,Yamazaki M,Onizawa M,Nisha JOSE,Tokai A,Kawai L,Watanabe M. TNFR2 signaling in colonic epithelia may be involved in the development of colitis-associated carcinogenesis.. AOCC2015 2015.06.20 Beijing

  16. 白崎友彬, 福島啓太, 土屋輝一郎, 日比谷秀爾, 林　亮平, 堀田伸勝, 岡本隆一, 中村哲也, 渡辺　守. Atoh1 protein stabilized by TNF-α acquires enhanced malignant potential in colitis-associated colorectal cancer.. AOCC2015 2015.06.19 北京

  17. Nobuyuki Horita, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Shuji Hibiya, Masayoshi Fukuda, Tomohiro Mizutani, Ryuichi Okamoto, Testuya Nakamura and Mamoru Watanabe. A novel fluorescent labelling system into small intestinal organoid reveals independent long-lived intestinal stem cells in a crypt.. AOCC2015 2015.06.19 Beijing

  18. Kohei Suzuki,Satoru Fujii,Toru Nakata,Ami Kawamoto,Fumiaki Ishibashi,Sayaka Ohashi Segawa, Tomohiro Mizutani, Kiichiro Tsuchiya,Kazuo Otsuka,Tetsuya Nakamura,Ryuichi Okamoto,Mamoru Watanabe. Enrichment of Intestinal Stem Cells by the 3D-Culture of IBD Patient Derived Intestinal epithelium. AOCC2015 2015.06.19 Beijing

  19. Fujii T,Takenaka K,Kitazume Y,Saito E,Matsuoka K,Nagahori M,Ohtsuka K,Watanabe M.. Modifying and validating endoscopic and magnetic resonance scoring systems for the deep small intestine in Crohn’s disease.. AOCC2015 2015.06.19 Beijing

  20. Kitahata F, Asahina Y, Watanabe M. Gene alterations in TERT promoter, CTNNB1, and TP53 are closely associated with development and prognosis of hepatocellular carcinoma: Comprehensive analyses by next generation sequencing technology.. The 3rd JSGE International Topic Conference 2015.05.24 Sendai

  21. Toru Nakata, Hiromichi Shimizu, Kohei Suzuki, Satoru Fujii, Go Ito, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Katsuto Hozumi, Mamoru Watanabe. Distinct Role of Notch Ligands, DLL1 and Dll4, in Normal and in Tumor Intestinal Epithelium. DDW 2015 2015.05.19 Washington, D.C.

  22. Shuji Hibiya, Kiichiro Tsuchiya, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Continuous Stimulation With Cytokines Leads to Irreversible Accumulation of NF-kB Signaling in Colonic Epithelial Cells. DDW 2015 2015.05.19 Washinguton DC

  23. Takashi Nagaishi, Taro Watabe, Masahiro Suzuki, Motomi Yamazaki, Nisha Jose, Arisa Tokai, Akinori Hosoya, Mamoru Watanabe. Epithelial NF-kB Activation via TNF Signaling May Be Involved in the Development of Colitis-Associated Carcinogenesis. DDW 2015 2015.05.18 Washington, D.C.

  24. Ryohei Hayashi, Kiichiro Tsuchiya, Shuji Hibiya, Keita Fukushima, Nobukatsu Horita, Eriko Okada, Akihiro Araki, Kazuo Ohtsuka, Mamoru Watanabe. Human Alpha-Defensin 6 Regulated by the Cooperation of Beta-Catenin and ATOH1, Might Be the Pathogenesis of Crohn's Disease. DDW 2015 2015.05.18 Washington, D.C.

  25. Toshimitsu Fujii, Kento Takenaka, Eiko Saito, Katsuyoshi Matsuoka, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe. Modifying and Validating Endoscopic and Magnetic Resonance Scoring Systems for the Deep Small Intestine in Crohn's Disease. DDW 2015 2015.05.17 Washington, D.C.

  26. Keita Fukushima, Kiichiro Tsuchiya, Shuji Hibiya, Ryohei Hayashi, Nobukatsu Horita, Yoshihito Kano, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Atoh1 Protein Expression by TNF-a and the Acquisition of Malignant Potential in Colitis- Associated Colorectal Cancer. DDW 2015 2015.05.17 Washington, D.C.

  27. Yui Shiro Y, Jordi Guiu, Pawel Schweiger, Carsten Friis Rundsen, Kim Jensen. The Cellular Plasticity of Adult and Fetal Intestinal Epithelium and its functional Evaluation by Grafting Assay.. DDW2015 2015.05.16 Washington DC

  28. Shiro Yui, Jordi Guiu, Pawel Schweiger, Carsten Friis Rundsen, Kim Jensen. The Cellular Plasticity of Adult and Fetal Intestinal Epithelium and its functional Evaluation by Grafting Assay. DDW 2015 2015.05.16 Washington, D.C.

  29. Hiromichi Shimizu, Kohei Suzuki, Satoru Fujii, Toru Nakata, Go Ito, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Katsuto Hozumi, Mamoru Watanabe. Notch Ligands DLL1 and Dll4 Are Expressed by Distinct Population of Epithelial Cells in the Mice Intestine. DDW 2015 2015.05.16 Washington, D.C.

  30. Fukiko Kawai-Kitahata, Yasuhiro Asahina, Shun Kaneko, Hiroko Nagata, Fumio Goto, Satoshi Otani, Miki Taniguchi, Miyako Murakawa, Sayuri Nitta, Takako Watanabe, Megumi Tasaka-Fujita, Yuki Nishimura-Sakurai, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Sei Kakinuma, Shinji Tanaka , Minoru Tanabe, Nobuyuki Enomoto and Mamoru Watanabe. Gene alterations in TERT promoter, CTNNB1, and TP53 are closely associated with development and prognosis of hepatocellular carcinoma : Comprehensive analyses by next generation sequencing technology. The 3rd JSGE International Topic Conference 2015.04.24 Sendai

  31. Asahina Y, Kawai-Kitahata F, Kaneko S, Nagata H, Goto F, Otani S, Taniguchi M, Murakawa M, Nitta S, Watanabe T, Tasaka-Fujita M, Nishimura-Sakurai Y, Itsui Y, Nakagawa M, Azuma S, Kakinuma S, Tanaka S, Tanabe M, Enomoto N, Watanabe M. Gene alterations in tert promoter, CTNNB1, and TP53 are closely associated with development and prognosis of hepatocellular carcinoma: comprehensive analyses by next generation sequencing technology. 50th The International liver congress 2015, EASL 2015.04.22 Vienna

  32. Shuji Hibiya, Kiichiro Tsuchiya, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Yoshihito Kano, Ryuichi Okamoto, Tetsuya Nakamura,Mamoru Watanabe. Continuous stimulation with cytokines leads to irreversible accumulation of NF-κB signaling in colonic epithelial cells. The 5th International Symposium on Carcinogenic Spiral 2015.02.26 Kobe

  33. Shuji Hibiya, Kiichiro Tsuchiya, Keita Fukushima, Ryohei Hayashi, Nobukatsu Horita, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Long-term stimulation with cytokines acquires irreersible accumulation of NF-κB signaling in colonic epithelial cells. 10th Congress of ECCO - Inflammatory Bowel Diseases 2015 2015.02.20 Barcelona

  34. Ryohei Hayashi, Kiichiro Tsuchiya, Shuji Hibiya, Keita Fukushima, Nobukatsu Horita, Eriko Okada, Akihiro Araki, Kazuo Ohtsuka, Mamoru Watanabe. Human alpha-defensin 6 regulated by both Atoh1 and beta-catenin might be the pathogenesis of Japanese Crohn's Disease. 10th Congress of ECCO - Inflammatory Bowel Diseases 2015 2015.02.20 Barcelona

  35. Matsuoka K, Saito E, Fujii T, Takenaka K, Nagahori M, Ohtsuka K, Watanabe M. The Ulcerative Colitis Endscopic Index of Severity (UCEIS) is useful to evaluate endoscopic improvement and to predict medium-term prognosis in Ulcerative Colitis patients treated with tacrolimus. 10th Congress of ECCO - Inflammatory Bowel Diseases 2015 2015.02.20 Barcelona

  1. Go Ito, Ryuichi Okamoto, Tasturo Murano, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Notch signaling and TNF-αsynergistically up-regulates expression of OLFM4 in human intestinal epithelial cells.. 第8回Japan-US Collabaration Conference in Gastroenterology 2014.11.21 Tokyo

  2. Watanabe T, Asahina Y, Nakagawa M, Kakinuma S, Itsui Y, Taniguchi M, Murakawa M, Nagata H, Miura M, Maekawa S, Enomoto N, Watanabe M. Emergence or selection of resistant associated variant immediately after initiation of the therapy is predictive for failure of direct acting antiviral therapy:ultra-deep sequencing analyses for serial time points. The 65th. Annual Meeting of American Association for the Study of Liver Diseases（AASLD The Liver Meeting 2014) 2014.11.11 Boston

  3. Otani S, Kakinuma S, Watanabe M. Matrix Metalloproteinase-14 regulates the maturation of fetal hepatic stem/progenitor cells in mice. The 65th. Annual Meeting of American Association for the Study of Liver Diseases（AASLD The Liver Meeting 2014) 2014.11.11 Boston

  4. Murakawa M, Asahina Y, Nakagawa M, Kawai-Kitahata F, Taniguchi M, Nitta S, Watanabe T, Itsui Y, Kakinuma S, Sakamoto N, Watanabe M. Expression of IFNλ4 in liver and PBMC is closely associated with higher basal expression of ISGs and impaired induction of IL28B by interferon treatment in chronic hepatitis C non-responder patients. The 65th. Annual Meeting of American Association for the Study of Liver Diseases（AASLD The Liver Meeting 2014) 2014.11.11 Boston

  5. Kawai-Kitahata F, Asahina Y, Kaneko S, Nagata H, Goto F, Otani S, Taniguchi M , Murakawa M , Nitta S, Watanabe T, Itsui Y, Nakagawa M, Kakinuma S, Enomoto N, Watanabe M. Gene alterations in β-catenin and p53/cell cycle control pathway are closely associated with development and prognosis of hepatocellular carcinoma: Comprehensive analyses by next generation sequencing technology. The 65th. Annual Meeting of American Association for the Study of Liver Diseases（AASLD The Liver Meeting 2014) 2014.11.10 Boston

  6. Nakagawa M, Asahina Y, Taniguchi M, Watanabe T, Nishimura-Sakurai Y, Itsui Y, Azuma S, Kakinuma S, Tanaka Y, Watanabe M. Impact of host and therapeutic factors and resistant associated variants on response to interferon based-direct acting antiviral treatment in difficult-to-treat chronic hepatitis C patients. The 65th. Annual Meeting of American Association for the Study of Liver Diseases（AASLD The Liver Meeting 2014) 2014.11.09 Boston

  7. Ryuichi Okamoto,Tetsuya Nakamura,Mamoru Watanabe. Functional analysis of primary-cultured human intestinal epithelial cells. 新学術領域「天然物ケミカルバイオロジー」 第5回公開シンポジウム 2014.10.28 横浜

  8. Takenaka K, Ohtsuka K, Watanabe M. Enteroscopic and MR findings of small intestine in Crohn's disease. Japan Digesive Disease Weeks 2014 2014.10.26 Kobe

  9. Otani S, Kakinuma S, Kamiya A, Goto F, Kaneko S, Azuma S, Asahina Y, Watanabe M. Matrix Metalloproteinase-14 controls differentiation of fetal hepatic stem/progenitor cells. Japan Digesive Disease Weeks 2014 2014.10.23 Kobe

  10. Okamoto R, Ito G, Shimizu H, Fujii S, Nakata T, Suzuki K, Watanabe M. Notch signaling regulates expression of gelsolin superfamily genes, gelsolim and scinderin and promotes re-assembly of action cytoskeleton in human intestinal epithelial cells. UEGW2014 2014.10.22 Vienna

  11. Jose N, Nagaishi T, Watabe T, Tokai A, Suzuki M, Yamazaki M, Watanabe M. The expression of myosin light chain kinase induced by NK-KB activation is involved in the development of colitis-associated cancer. UEGW2014 2014.10.22 Vienna

  12. Ito G, Okamoto R, Shimizu H, Fujii S, Nakata T, Suzuki K, Tsuchiya K, Nakamura T, Watanabe M. Notch Signaling and TNF-alpha synergistically promotes intracellular protein accumulation of olfm4 in the inflamed mucosa of ulcerative colitis. UEGW2014 2014.10.21 Vienna

  13. Fujii T, Naganuma M, Kitazume Y, Takenaka K, Nagahori M, Saito E, Ohtsuka K, Watanabe M. MR enterocolonography can identify patients who need additional treatment by predicting recurrence, hospitalization and surgey of Crohn's disease patients in remission. UEGW2014 2014.10.20 Vienna

  14. Takenaka K, Ohtsuka K, Kitazume Y, Nagahori M, Fujii T, Saito E, Watanabe M. Magnetic resonance enterocolonography can detect small intestinal active lesions in crohn's disease;comparison with balloon enteroscopy. UEGW2014 2014.10.20 Vienna

  15. Go Ito, Ryuichi Okamoto, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Kohei Suzuki, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Notch signaling and TNF-α synergistically promotes intracellular protein expression of OLFM4 in human intestinal epithelial cells. The 2nd Annual Meeting of Asian Organization for Crohn's and Colitis 2014.06.21 Seoul

  16. Hiromichi Shimizu, Ryuichi Okamoto, Go Ito, Satoru Fujii, Toru Nakata, Kohei Suzuki, Tatsuro Murano, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe. Distinct Expression Patterns of Notch Ligands, DLL1 and DLL4, in Normal and Inflamed Mice Intestine. The 2nd Annual Meeting of Asian Organization for Crohn's and Colitis 2014.06.21 Seoul

  17. Takenaka K, Otsuka K, Nagahori M, Fujii T, Saito E, Watanabe M. Comparison of Magnetic Resonance and Balloon Enteroscopic Examination of Deep Small Intestine in Patients with Crohn's Disease. The 2nd Annual Meeting of AOCC 2014.06.20 Seoul

  18. Mizutani T. Successful Engraftment of Cultured Small Intestinal Epithelial Stem Cells onto Damaged Colonic Mucosa by Heterotopic Transplantation. GI Research Academy 2014 2014.06.06 Tokyo

  19. Horita N, Tsuchiya K, Hayashi R, Fukushima K, Hibiya S, Fukuda M, Kano Y, Mizutani T, Nemoto Y, Yui S, Okamoto R, Nakamura T, Watanabe M . Establishment of the gene transduction into the primary intestinal organoid identified the subpopulation of the stem cells in a crypt.. 第12回幹細胞シンポジウム 2014.05.31 福岡

  20. Mizutani T, Fukuda M, Mochizuki W, Matsumoto T, Nozaki K, Ichinose S, Watanabe M, Nakamura T. Successful Engraftment of Cultured Small Intestinal Epithelial Stem Cells onto Damaged Colonic Mucosa by Heterotopic Transplantation. Digestive Disease Week 2014 2014.05.03 Chicago

  21. Takenaka K, Otsuka K, Nagahori M, Fujii T, Saito E, Watanabe M. Comparing MR enterocolonography to enteroscopy in Crohn's disease, especially focusing on small intestinal findings. 9th congress of European Crohn's and Colitis Organisation 2014.02.20 Copenhagen

  22. Hibiya S, Tsuchiya K, Fukushima K, Hayashi R, Horita N, Kano Y , Okamoto R, Nakamura T,Watanabe M. Long-term stimulation with cytokines acquires irreversible accumulation of NF-κB signaling in primary colonic epithelial cells. 4th International Symposium on Carcinogenic Spiral 2014.02.11 Sapporo

  1. 岡本隆一,村野竜朗,伊藤　剛,中田　徹,日比谷秀爾,藤井　悟,清水寛路,水谷知裕,土屋輝一郎,中村哲也,渡辺　守. 炎症性腸疾患におけるNotch-Hes1シグナルを介した粘膜再生機構の解析. 浜名湖シンポジウム 2013.12.21 浜松

  2. Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Proliferation, Differentiation and Tissue Repair of the Intestinal Epithelium. 新学術領域「天然物ケミカルバイオロジー」 第2回国際シンポジウム 2013.10.29 Yokohama

  3. Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Potential of primary cultured intestinal epithelial cells as a tool for biochemical analysis. 新学術領域「天然物ケミカルバイオロジー」 第4回公開シンポジウム 2013.10.28 Yokohama

  4. R Okamoto , T Murano , H Shimizu , G Ito , S Fujii , T Nakata , K Tsuchiya , T Nakamura , M Watanabe. Il-22-mediated antimicrobial response is regulated by hes1 via stat3-dependent transcription in human intestinal epithelial cells.. UEGW 2013 2013.10.16 Berlin

  5. G Ito, R Okamoto, T Murano , H Shimizu , K Tsuchiya , T Nakamura , M Watanabe. Lineage-specific expression of bestrophin-2 and bestrophin-4 is regulated by notch signaling in human intestinal epithelial cells.. UEGW 2013 2013.10.14 Berlin

  6. H Shimizu , R Okamoto , T Nakata , S Fujii , G Ito , T Murano , K Tsuchiya , T Nakamura , M Watanabe. Complete conversion of crypt progenitor cells into atoh1-positive cells by targeted deletion of dll1 and dll4 in lgr5-positive intestinal stem cells.. UEGW 2013 2013.10.14 Germany

  7. 岡本隆一. ここまで解ってきたIBDの病態-goblet細胞と潰瘍性大腸炎-. 第31回　大腸病態治療研究会 2013.06.27 大阪

  8. Ryuichi Okamoto, Tatsuro Murano, Hiromichi Shimizu, Go Ito, Satoru Fujii, Kiichiro Tsuchiya, Tetsuya Nakamura, and Mamoru Watanabe. Hes1 promotes IL-22-mediated antimicrobial response through enhancement of STAT3-dependent transcription in human intestinal epithelial cells. The 1st Annual Meeting of Asian Organization for Crohn's and Colitis 2013.06.13 品川

  9. Go Ito, Ryuichi Okamoto, Tatsuro Murano, Hiromichi Shimizu, Satoru Fujii, Kiichiro Tsuchiya, Tetsuya Nakamura, and Mamoru Watanabe. Lineage-specific expression of bestrophin genes in normal and inflamed human intestine: implications for ulcerative colitis.. The 1st Annual Meeting of Asian Organization for Crohn's and Colitis 2013.06.13 Tokyo

  10. 谷口未樹、中川美奈、 朝比奈靖浩　柿沼　晴、東　正新、渡辺貴子、櫻井　幸、村川美也子、大谷賢志、河合富貴子、後藤文男、坂本直哉、渡辺　守. 慢性肝疾患における肝細胞癌とIL-6 の関連. 第49回日本肝臓学会総会 2013.06.06 京王プラザホテル（東京都新宿区）

  11. Go Ito, Ryuichi Okamoto, Satoru Fujii, Hiromichi Shimizu, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Notch signaling regulates expression of Bestrophin-4, a novel enterocyte-specific HCO3-/Cl- channel, in human intestinal epithelial cells.. DDW 2013 2013.05.20 Orlando

  12. Hiromichi Shimizu, Ryuichi Okamoto, Satoru Fujii, Go Ito, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Complete conversion of crypt progenitor cells into Atoh1-positive cells by targeted deletion of Dll1 and Dll4 in Lgr5-positive intestinal stem cells. DDW 2013 2013.05.19 Orlando

  13. 新田沙由梨、朝比奈靖浩、柿沼　晴、坂本直哉、渡辺　守. ウイルス肝炎における自然免疫応答抑制メカニズムの解析. Liver Forum in Kyoto　第16回学術集会 2013.03.29 京都

  1. 油井史郎、中村哲也、渡辺　守. マウスおよびヒトの正常な腸管上皮初代培養法の確立.. 第3回Japan Gut Forum 2012.11.24 東京

  2. Ryuichi Okamoto, Go Ito, Satoru Fujii, Hiromichi Shimizu, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Hes1 promotes IL-22-mediated epithelial regeneration through enhancement of STAT3-dependent transcription in human intestinal epithelial cells. Asian IBD Symposium 2012.11.03 Seoul

  3. Hiromichi Shimizu, Ryuichi Okamoto, Satoru Fujii, Go Ito, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Identification of Notch ligand expressing cells in normal and inflamed intestinal mucosa. Asian IBD Symposium 2012.11.03 Seoul

  4. Takahiro Mutoh, Ryuichi Okamoto, Go Ito, Satoru Fujii, Hiromichi Shimizu, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru . Notch signaling and TNF-alpha synergistically up-regulate OLFM4 expression in human intestinal epithelial cells. Asian IBD Symposium 2012.11.03 Seoul

  5. Ryuichi Okamoto, Go Ito, Satoru Fujii, Hiromichi Shimizu, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Notch signaling and TNF-alpha synergistically up-regulate OLFM4 expression in human intestinal epithelial cells. UEGW 2012 2012.10.23 Amsterdam

  6. Go Ito, Ryuichi Okamoto, Satoru Fujii, Hiromichi Shimizu, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Notch signaling regulates expression of Bestrophin-4, a novel enterocyte-specific HCO3-/Cl- channel, in human intestinal epithelial cells.. UEGW 2012 2012.10.23 Amsterdam

  7. Shiro Yui, Tetsuya Nakamura, Yasuhiro Nemoto, Tomohiro Mizutani, Masayoshi Fukuda, Kengo Nozaki, Yuuishi Yamauchi, Wakana Mochizuki, Xiu Zheng, Takashi Nagaichi, Ryuichi Okamoto, Kiishiro Ysuchiya, Mamoru Watanabe. 【Colon Stem Cell】Regeneration of damaged colon epithelium by transplanted colon Lgr5+ stem cells maintained and expanded in vitro. 第10回幹細胞シンポジウム 2012.06.01 淡路夢舞台国際会議場（兵庫県）

  8. Yasuhiro Nemoto, Takanori Kanai, Satoshi Matsumoto, Mamoru Watanabe. Colitogenic effector memory CD4+ T cells develop Th1/Th17 mediated interstitial pneumonia independent to intestinal bacterial antigens. Digestive Disease Week 2012 2012.05.22

  9. Mizutani T, Nakamura T, Morikawa R, Fukuda M, Mochizuki W, Yamauchi Y, Nozaki K, Yui S, Okamoto R, Tsuchiya K, Watanabe M. Real-time analysis of p-glycoprotein-mediated drug transport across primary intestinal epitherial cells three-dimensionally cultured in vitro. DDW 2012 2012.05.19 San Diego

  10. Fujii T, Naganuma M, Saito E, Nagahori M, Watanabe M. Intravenous tacrolimus therapy can rapidly induce remission in refractory ulcerative colitis. DDW2012 2012.05.19 San Diego

  11. Yasuhiro Nemoto, Takanori Kanai, Satoshi Matsumoto, Mamoru Watanabe. Colitogenic effector memory CD4+ T cells develop Th17 mediated interstitial pneumonia independent to intestinal bacterial antigens. 第98回日本消化器病学会総会（International Forum） 2012.04.20

  12. Yasuhiro Nemoto, Takanori Kanai, Mamoru Watanabe. Luminal CD4+ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation. he Surface Barrier Immunology Study Group 3rd Meeting 2012.03.23

  13. Ryuichi Okamoto, Go Ito, Satoru Fujii, Hiromichi Shimizu, Tatsuro Murano, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Notch-Hes1 pathway and TNF-α synergistically up-regulates OLFM4 expression in the inflamed mucosa of the human intestine. 6th Korea-Japan IBD Symposium 2012.01.28 Tokyo

  14. Tatsuro Murano, Ryuichi Okamoto, Go Ito, Satoru Fujii, Hiromichi Shimizu, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Hes1 promotes IL-22-mediated epithelial regeneration through enhancement of STAT3-dependent transcription in human intestinal epithelial cells. 6th Korea-Japan IBD Symposium 2012.01.28 Tokyo

  1. Yui S. Regeneration of damaged colon epithelium by transplanted colon atem cells maintained and expanded in vitro.. The 5th Japan & US Collaboration Conference in Gastroenterology 2011.11.09 Tokyo

  2. Yasuhiro Nemoto, Takanori Kanai, Tamako Shinohara, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Luminal CD4+ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation. 15th International Congress of Mucosal Immunology 2011.07.07

  3. Yui S, Nemoto Y, Mizutani T, Zheng X, Nagaishi T, Tsuchiya K, Watanabe M, Nakamura T, Okamoto R, Ichinose S, Sato T, Clevers H. Regeneration of damaged colonic tissue by transplanted colonic epithelial stem cells maintained and expanded in vitro.. GI Research Academy 2011 2011.06.17 Kyoto

  4. Yasuhiro Nemoto, Takanori Kanai, Tamako Shinohara, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. IL-7Rα expression on CD4+ T cells, but not on other cells is essential for the development of chronic colitis. Digestive Disease Week 2011 2011.05.10

  5. Yui S, Nakamura T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, Nagaishi T, Okamoto R, Tsuchiya K, Sato T, Clevers H, Watanabe M. Regeneration of Damaged Colonic Tissue by Transplantation of Colonic Epithelial Stem Cells Maintained and Expanded In Vitro.. DDW2011 2011.05.07 McCormick Place（Chicago,USA）

  1. Yui S, Nakamura T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, Nagaishi T, Okamoto R, Tsuchiya K, Watanabe M. A well-defined culture system for colonic epithelial cells thet allows efficient enrichment of LGR5+ stem cells. The 1st JSGE International Topic Conference 2010.09.25 Kamakura Park Hotel（Kanagawa Japan)

  2. Yasuhiro Nemoto, Takanori Kanai, Mamoru Watanabe. IL-7-producing mesenchymal stromal cells sustain colitogenic memory CD4+ T cells for the persistence of chronic colitis. Digestive Disease Week 2010 2010.05.02

  1. Yasuhiro Nemoto, Takanori Kanai, Kaori Kameyama, Tamako Shinohara, Naoya Sakamoto, Teruji Totsuka, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Satoshi Matsumoto, Mamoru Watanabe. Long-lived Colitogenic CD4+ Memory T Cells can be Maintained Outside the Intestine in the Absence of Commesal Bacteria. 14th International Congress of Mucosal Immunology 2009.07.07

  2. Yasuhiro Nemoto, Takanori Kanai, Kaori Kameyama, Tamako Shinohara, Naoya Sakamoto, Teruji Totsuka, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Satoshi Matsumoto, Mamoru Watanabe. Long-lived Colitogenic CD4+ Memory T Cells Residing Outside the Intestine Participate in the Perpetuation of Chronic Colitis. Digestive Disease Week 2009 2009.05.31

  1. Yasuhiro Nemoto, Takanori Kanai, Shuji Tohda, Teruji Totsuka, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Fukuda, Hideo Yagita, Mamoru Watanabe. Negative Feedback Regulation of Pathogenic CD4+ T Cells by Increased Granulopoiesis. Digestive Disease Week 2008 2008.05.20

  1. Yasuhiro Nemoto, Takanori Kanai, Shin Makita, Teruji Totsuka, Mamoru Watanabe. Bone marrow is a reservoir for persistent colitogenic CD4+TEM cells in IL-7 dependent manner. International Congress of Mucosal Immunology 2007 2007.07.10

  2. Yasuhiro Nemoto, Takanori Kanai, Shin Makita, Rei Fujii, Ryuichi Okamoto, Teruji Totsuka,　Mamoru Watanabe. Bone marrow latently retaining colitogenic CD4+ T cells may be a pathogenic reservoir for lifelong chronic colitis. Digestive Disease Week 2007 2007.05.20

  1. Yasuhiro Nemoto, Takanori Kanai, Shin Makita, Rei Fujii, Ryuichi Okamoto, Teruji Totsuka,　Mamoru Watanabe. Bone marrow latently retaining colitogenic memory CD4+ T cells may be a pathogenic reservoir for lifelong chronic colitis. Digestive Disease Week 2006 2006.05.20

  1. Nemoto Y, Kanai T, Makita S, Fujii R, Kawamura T, Totsuka T, Watanabe M. Murine Lamina Propria CD4+ T Cells Suppress the Development of Chronic Colitis . 12th International Congress of Mucosal Immunology 2005.06.26

  1. Real world experience with tofacitinib in refractory ulcerative colitis.. 2020.02.07

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