1. Alain Rios, Kyohei Fujita, Yoshikazu Isomura, Nobuya Sato: Adaptive circuits for action and value information in rodent operant learning Neuroscience Research. 2024.09; ( DOI )

  2. Alain Rios, Kyohei Fujita, Yoshikazu Isomura, Nobuya Sato: Adaptive circuits for action and value information in rodent operant learning Neuroscience Research. 2024.09; in press.

  3. Hikaru Sugino, Sho Tanno, Tatsumi Yoshida, Yoshikazu Isomura, Riichiro Hira: Functional segregation and dynamic integration of the corticotectal descending signal in rat Neuroscience Research. 2024.09; in press.

  4. Hikaru Sugino , Sho Tanno , Tatsumi Yoshida , Yoshikazu Isomura , Riichiro Hira: Dynamic integration of cortical activity in the deep layer of the anterolateral superior colliculus bioRxiv (preprint). 2024.07; ( DOI )

  5. Tatsumi Yoshida , Hikaru Sugino , Hinako Yamamoto , Sho Tanno , Mikihide Tamura , Jun Igarashi , Yoshikazu Isomura , Riichiro Hira: Synergistic reinforcement learning by cooperation of the cerebellum and basal ganglia bioRxiv (preprint). 2024.07; ( DOI )

  6. Closed-loop experiments and brain machine interfaces with multiphoton microscopy Neurophotonics. 2024.02;

  1. Koji Ikezoe, Naoki Hidaka, Satoshi Manita, Masayoshi Murakami, Shinichiro Tsutsumi, Yoshikazu Isomura, Masanobu Kano, Kazuo Kitamura: Cerebellar climbing fibers multiplex movement and reward signals during a voluntary movement task in mice. Commun Biol. 2023.09; 6 (1): 924. ( PubMed , DOI )

  2. Rios A, Nonomura S, Kato S, Yoshida J, Matsushita N, Nambu A, Takada M, Hira R, Kobayashi K, Sakai Y, Kimura M, Isomura Y: Reward expectation enhances action-related activity of nigral dopaminergic and two striatal output pathways Commun Biol. 2023.09; 6 (1): 914. ( PubMed , DOI )

  3. Riichiro Hira, Leah B. Townsend, Ikuko T. Smith, Che-Hang Yu, Jeffrey N. Stirman, Yiyi Yu, Spencer LaVere Smith: Mesoscale functional architecture in medial posterior parietal cortex bioRxiv (preprint). 2023.08; ( DOI )

  4. Shogo Soma, Shinya Ohara, Satoshi Nonomura, Naofumi Suematsu, Junichi Yoshida, Eva Pastalkova, Yutaka Sakai, Ken-Ichiro Tsutsui, Yoshikazu Isomura: Rat hippocampal CA1 region represents learning-related action and reward events with shorter latency than the lateral entorhinal cortex. Commun Biol. 2023.05; 6 (1): 584. ( PubMed , DOI )

  5. Tomohiko Yoshizawa , Yuuto Miyamura , Yuta Ochi , Riichiro Hira , Makoto Funahashi , Yutaka Sakai , Yilong Cui , Yoshikazu Isomura: Working memory-based and -free reward prediction in a dual dopamine system in the basal ganglia bioRxiv (preprint). 2023.03; ( DOI )

  1. Keita Mitani, Masanori Kawabata, Yoshikazu Isomura, Yutaka Sakai: Automated and parallelized spike collision tests to identify spike signal projections iScience. 2022.09; 25 (10): 105071. ( DOI )

  2. Koji Ikezoe, Naoki Hidaka, Satoshi Manita, Masayoshi Murakami, Shinichiro Tsutsumi, Yoshikazu Isomura, Masanobu Kano, Kazuo Kitamura: Cerebellar climbing fibers convey behavioral information of multiplex modalities and form functional modules bioRxiv. 2022.08; (preprint).

  3. Soma S, Ohara S, Nonomura S, Yoshida J, Suematsu N, Pastalkova E, Sakai Y, Tsutsui K-I, Isomura Y: Hippocampal CA1 represents action and reward events instantly compared to the superficial and deep layers of the lateral entorhinal cortex bioRxiv. 2022.04; (preprint). ( DOI )

  1. CH Yu, JN Stirman, Y Yu, R Hira, SL Smith: Diesel2p mesoscope with dual independent scan engines for flexible capture of dynamics in distributed neural circuitry Nature Communications. 2021.11; 12 (1): 6639. ( PubMed , DOI )

  2. Kazuhiko Ishigaki, Keiki Kumano, Kyohei Fujita, Hiroo Ueno: Cellular basis of omentum activation and expansion revealed by single-cell RNA sequencing using a parabiosis model. Sci Rep. 2021.07; 11 (1): 13958. ( PubMed , DOI )

  3. Motoki Kajiwara, Ritsuki Nomura, Felix Goetze, Masanori Kawabata, Yoshikazu Isomura, Tatsuya Akutsu, Masanori Shimono: Inhibitory neurons exhibit high controlling ability in the cortical microconnectome. PLoS Comput Biol. 2021.04; 17 (4): e1008846. ( PubMed , DOI )

  4. Shun Hamada, Masashi Nagase, Tomohiko Yoshizawa, Akari Hagiwara, Yoshikazu Isomura, Ayako M Watabe, Toshihisa Ohtsuka: An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping. Commun Biol. 2021.04; 4 (1): 461. ( PubMed , DOI )

  1. Masanori Kawabata, Shogo Soma, Akiko Saiki-Ishikawa, Satoshi Nonomura, Junichi Yoshida, Alain Ríos, Yutaka Sakai, Yoshikazu Isomura: A spike analysis method for characterizing neurons based on phase locking and scaling to the interval between two behavioral events. J Neurophysiol. 2020.12; 124 (6): 1923-1941. ( PubMed , DOI )

  2. 田中 慧介, 田中 準一, 相澤 怜, 吉田 真子, 松浦 徹, 藤田 恭平, 田中 麻友, 上野 博夫, 美島 健二, 山本 松男: 多色細胞系譜追跡法を用いた歯肉接合上皮細胞のクローナリティ解析 日本歯周病学会会誌. 2020.10; 62 108. ( ichushi )

  3. Tomoko Tanaka, Yoshikazu Isomura, Kazuto Kobayashi, Takashi Hanakawa, Satoshi Tanaka, Manabu Honda: Electrophysiological effects of transcranial direct current stimulation on neural activity in the rat motor cortex Frontiers in Neuroscience. 2020.06; 14 article 495. ( DOI )

  4. Saegusa Hironao, Li Xu, Wang Xinshuang, Kayakiri Midori, Tanabe Tsutomu: Knockdown of microglial Cav2.2 N-type voltage-dependent Ca(2+)channel ameliorates behavioral deficits in a mouse model of Parkinson's disease FEBS LETTERS. 2020.06; ( PubMed , DOI )

  5. Kato Daisuke, Wake Hiroaki, Lee Philip, Tachibana Yoshihisa, Ono Riho, Sugio Shouta, Tsuji Yukio, Tanaka Yasuyo, Tanaka Yasuhiro, Masamizu Yoshito, Hira Riichiro, Moorhouse Andrew, Tamamaki Nobuaki, Ikenaka Kazuhiro, Matsukawa Noriyuki, Fields Douglas, Nabekura Junichi, Matsuzaki Masanori: 学習障害を引き起こす髄鞘機能障害の神経回路基盤(Illumination of abnormal neural activities caused by myelin impairment suggests possible contribution to learning deficits) The Journal of Physiological Sciences. 2020.03; 70 (Suppl.1): S172. ( ichushi )

  6. Soma Shogo, Saiki Akiko, Yoshida Junichi, Kato Shigeki, Takahashi Yukari, Nonomura Satoshi, Sugimura Yae K., Rios Alain, Kawabata Masanori, Kobayashi Kazuto, Kato Fusao, Sakai Yutaka, Isomura Yoshikazu: ラット運動野および頭頂連合野における前肢運動の対側・同側情報表現 The Journal of Physiological Sciences. 2020.03; 70 (Suppl.1): S75. ( ichushi )

  7. Daisuke Kato, Hiroaki Wake, Philip R Lee, Yoshihisa Tachibana, Riho Ono, Shouta Sugio, Yukio Tsuji, Yasuyo H Tanaka, Yasuhiro R Tanaka, Yoshito Masamizu, Riichiro Hira, Andrew J Moorhouse, Nobuaki Tamamaki, Kazuhiro Ikenaka, Noriyuki Matsukawa, R Douglas Fields, Junichi Nabekura, Masanori Matsuzaki: Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity. Glia. 2020.01; 68 (1): 193-210. ( PubMed , DOI )

  1. Tsutsumi S, Hidaka N, Isomura Y, Matsuzaki M, Sakimura K, Kano M, Kitamura K: Modular organization of cerebellar climbing fiber inputs during goal-directed behavior. eLife. 2019.10; 8 e47021. ( PubMed , DOI )

  2. Huntula, S., Wang, X., Saegusa, H. and Tanabe, T.: Involvement of N-type Ca2+ channel in microglial activation and its implications to aging-induced exaggerated cytokine response. Cell Calcium. 2019.07; 82 102059. ( DOI )

  3. Rios A, Soma S, Yoshida J, Nonomura S, Kawabata M, Sakai Y, *Isomura Y: Differential changes in the lateralized activity of identified projection neurons of motor cortex in hemiparkinsonian rats. eNeuro. 2019.06; 6 (4): ENEURO.0110-19. ( PubMed , DOI )

  4. Soma Shogo, Yoshida Junichi, Kato Shigeki, Nonomura Satoshi, Sugimura Yae K., Rios Alain, Kawabata Masanori, Kobayashi Kazuto, Kato Fusao, Sakai Yutaka, Isomura Yoshikazu: げっ歯類後頭頂皮質は同側と同様に対側の運動も制御する The Journal of Physiological Sciences. 2019.06; 69 (Suppl.1): S250. ( ichushi )

  5. Wang, X., Saegusa, H., Huntula, S. and Tanabe, T. : Blockade of microglial Cav1.2 Ca2+ channel exacerbates the symptoms in a Parkinson’s disease model. Scientific Reports . 2019.06; 9 (9138): ( DOI )

  6. Hori Y, Ihara N, Sugai C, Ogura J, Honda M, Kato K, Isomura Y, *Hanakawa T: Ventral striatum links motivational and motor networks during operant-conditioned movement in rats. NeuroImage. 2019.01; 184 943-953. ( PubMed , DOI )

  7. *Soma S, Yoshida J, Kato S, Takahashi Y, Nonomura S, Sugimura YK, Ríos A, Kawabata M, Kobayashi K, Kato F, Sakai Y, Isomura Y: Ipsilateral-dominant control of limb movements in rodent posterior parietal cortex. The Journal of neuroscience. 2019.01; 39 (3): 485-502. ( PubMed , DOI )

  1. Teppei Ebina, Yoshito Masamizu, Yasuhiro R Tanaka, Akiya Watakabe, Reiko Hirakawa, Yuka Hirayama, Riichiro Hira, Shin-Ichiro Terada, Daisuke Koketsu, Kazuo Hikosaka, Hiroaki Mizukami, Atsushi Nambu, Erika Sasaki, Tetsuo Yamamori, Masanori Matsuzaki: Two-photon imaging of neuronal activity in motor cortex of marmosets during upper-limb movement tasks. Nat Commun. 2018.12; 9 (1): 1879. ( PubMed , DOI )

  2. Nonomura S, Nishizawa K, Sakai Y, Kawaguchi Y, Kato S, Uchigashima M, Watanabe M, Yamanaka K, Enomoto K, Chiken S, Sano H, Soma S, Yoshida J, Samejima K, Ogawa M, Kobayashi K, Nambu A, *Isomura Y, *Kimura M: Monitoring and Updating of Action Selection for Goal-Directed Behavior through the Striatal Direct and Indirect Pathways. Neuron. 2018.09; 99 (6): 1302-1314. ( PubMed , DOI )

  3. Yoshida J, Saiki A, Soma S, Yamanaka K, Nonomura S, Ríos A, Kawabata M, Kimura M, Sakai Y, *Isomura Y: Area-specific modulation of functional cortical activity during block-based and trial-based proactive inhibition. Neuroscience. 2018.08; 388 297-316. ( PubMed , DOI )

  4. G. Martín-Vázquez, T. Asabuki, Y. Isomura, T. *Fukai: Learning Task-Related Activities From Independent Local-Field-Potential Components Across Motor Cortex Layers Frontiers in Neuroscience. 2018.06; 12 Article 429. ( DOI )

  5. Daisuke Kondo, Hironao Saegusa, Tsutomu Tanabe: Involvement of phosphatidylinositol-3 kinase/Akt/mammalian target of rapamycin/peroxisome proliferator-activated receptor γ pathway for induction and maintenance of neuropathic pain. Biochem. Biophys. Res. Commun.. 2018.05; 499 (2): 253-259. ( PubMed , DOI )

  6. Saiki A, Sakai Y, Fukabori R, Soma S, Yoshida J, Kawabata M, Yawo H, Kobayashi K, Kimura M, *Isomura Y: In Vivo Spiking Dynamics of Intra- and Extratelencephalic Projection Neurons in Rat Motor Cortex. Cerebral cortex. 2018.03; 28 (3): 1024-1038. ( PubMed , DOI )

  7. Yiyi Yu, Riichiro Hira, Jeffrey N Stirman, Waylin Yu, Ikuko T Smith, Spencer L Smith: Mice use robust and common strategies to discriminate natural scenes. Sci Rep. 2018.01; 8 (1): 1379. ( PubMed , DOI )

  1. *Soma S, Saiki A, Yoshida J, Ríos A, Kawabata M, Sakai Y, Isomura Y: Distinct laterality in forelimb-movement representations of rat primary and secondary motor cortical neurons with intratelencephalic and pyramidal tract projections. The Journal of neuroscience. 2017.10; 37 (45): 10904-10916. ( PubMed , DOI )

  2. Handa T, Takekawa T, Harukuni R, Isomura Y, *Fukai T: Medial Frontal Circuit Dynamics Represents Probabilistic Choices for Unfamiliar Sensory Experience. Cerebral cortex. 2017.07; 27 (7): 3818-3831. ( PubMed , DOI )

  3. Ryuhei Ogawa, Kyohei Fujita, Kazuo Ito: Mouse embryonic dorsal root ganglia contain pluripotent stem cells that show features similar to embryonic stem cells and induced pluripotent stem cells. Biol Open. 2017.05; 6 (5): 602-618. ( PubMed , DOI )

  4. Nonomura S#, Fujiwara-Tsukamoto Y#, Kajihara T, Fujiyama F, *Isomura Y: Continuous membrane potential fluctuations in motor cortex and striatum neurons during voluntary forelimb movements and pauses. Neuroscience research. 2017.03; 120 53-59. ( PubMed , DOI )

  5. Kawabata Masanori, Soma Shogo, Saiki Akiko, Yoshida Junichi, Sakai Yutaka, Isomura Yoshikazu: ラットの多感覚促進を伴う行動に関連する大脳皮質の神経活動 The Journal of Physiological Sciences. 2017.03; 67 (Suppl.1): S184. ( ichushi )

  6. *Kimura R, Saiki A, Fujiwara-Tsukamoto Y, Sakai Y, Isomura Y: Large-scale analysis reveals populational contributions of cortical spike rate and synchrony to behavioral functions. The Journal of physiology. 2017.01; 595 (1): 385-413. ( PubMed , DOI )

  1. Kyohei Fujita, Ryuhei Ogawa, Kazuo Ito: CHD7, Oct3/4, Sox2, and Nanog control FoxD3 expression during mouse neural crest-derived stem cell formation. FEBS J. 2016.10; 283 (20): 3791-3806. ( PubMed , DOI )

  2. Takeuchi S, Murai R, Shimazu H, Isomura Y, Mima T, *Tsujimoto T: Spatiotemporal Organization and Cross-Frequency Coupling of Sleep Spindles in Primate Cerebral Cortex. Sleep. 2016.07; 39 (9): 1719-1735. ( PubMed , DOI )

  3. Mochizuki Y, Onaga T, Shimazaki H, Shimokawa T, Tsubo Y, Kimura R, Saiki A, Sakai Y, Isomura Y, Fujisawa S, Shibata K, Hirai D, Furuta T, Kaneko T, Takahashi S, Nakazono T, Ishino S, Sakurai Y, Kitsukawa T, Lee JW, Lee H, Jung MW, Babul C, Maldonado PE, Takahashi K, Arce-McShane FI, Ross CF, Sessle BJ, Hatsopoulos NG, Brochier T, Riehle A, Chorley P, Grün S, Nishijo H, Ichihara-Takeda S, Funahashi S, Shima K, Mushiake H, Yamane Y, Tamura H, Fujita I, Inaba N, Kawano K, Kurkin S, Fukushima K, Kurata K, Taira M, Tsutsui K, Ogawa T, Komatsu H, Koida K, Toyama K, Richmond BJ, *Shinomoto S（著者54名中9番目）: Similarity in Neuronal Firing Regimes across Mammalian Species. The Journal of neuroscience. 2016.05; 36 (21): 5736-5747. ( PubMed , DOI )

  1. Riichiro Hira, Shin-Ichiro Terada, Masashi Kondo, Masanori Matsuzaki: Distinct Functional Modules for Discrete and Rhythmic Forelimb Movements in the Mouse Motor Cortex. J. Neurosci.. 2015.09; 35 (39): 13311-13322. ( PubMed , DOI )

  2. Takeuchi S, Mima T, Murai R, Shimazu H, Isomura Y, *Tsujimoto T: Gamma Oscillations and Their Cross-frequency Coupling in the Primate Hippocampus During Sleep. Sleep. 2015.07; 38 (7): 1085-1091. ( PubMed , DOI )

  1. Cui W, Mizukami H, Yanagisawa M, Aida T, Nomura M, Isomura Y, Takayanagi R, Ozawa K, Tanaka K, *Aizawa H: Glial dysfunction in the mouse habenula causes depressive-like behaviors and sleep disturbance. The Journal of neuroscience. 2014.12; 34 16273-16285. ( PubMed , DOI )

  2. Riichiro Hira, Fuki Ohkubo, Yoshito Masamizu, Masamichi Ohkura, Junichi Nakai, Takashi Okada, Masanori Matsuzaki: Reward-timing-dependent bidirectional modulation of cortical microcircuits during optical single-neuron operant conditioning. Nat Commun. 2014.11; 5 5551. ( PubMed , DOI )

  3. Kyohei Fujita, Ryuhei Ogawa, Syunsaku Kawawaki, Kazuo Ito: Roles of chromatin remodelers in maintenance mechanisms of multipotency of mouse trunk neural crest cells in the formation of neural crest-derived stem cells. Mech Dev. 2014.08; 133 126-145. ( PubMed , DOI )

  4. Masamizu Y, Tanaka YR, Tanaka YH, Hira R, Ohkubo F, Kitamura K, Isomura Y, Okada T, *Matsuzaki M: Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task. Nature Neuroscience. 2014.07; 17 (7): 987-994. ( PubMed , DOI )

  5. Hironao Saegusa, Tsutomu Tanabe: N-type voltage-dependent Ca2+ channel in non-excitable microglial cells in mice is involved in the pathophysiology of neuropathic pain. Biochem. Biophys. Res. Commun.. 2014.07; 450 (1): 142-147. ( PubMed , DOI )

  6. Saiki A, Kimura R, Samura T, Fujiwara-Tsukamoto Y, Sakai Y, *Isomura Y: Different modulation of common motor information in rat primary and secondary motor cortices. PLoS ONE. 2014.06; 9 (6): e98662. ( PubMed , DOI )

  1. Brent Asrican, George J Augustine, Ken Berglund, Susu Chen, Nick Chow, Karl Deisseroth, Guoping Feng, Bernd Gloss, Riichiro Hira, Carolin Hoffmann, Haruo Kasai, Malvika Katarya, Jinsook Kim, John Kudolo, Li Ming Lee, Shun Qiang Lo, James Mancuso, Masanori Matsuzaki, Ryuichi Nakajima, Li Qiu, Gregory Tan, Yanxia Tang, Jonathan T Ting, Sachiko Tsuda, Lei Wen, Xuying Zhang, Shengli Zhao: Next-generation transgenic mice for optogenetic analysis of neural circuits. Front Neural Circuits. 2013.11; 7 160. ( PubMed , DOI )

  2. Igarashi J, Isomura Y, Arai K, Harukuni R, *Fukai T: A θ-γ Oscillation Code for Neuronal Coordination during Motor Behavior. The Journal of Neuroscience. 2013.11; 33 18515-18530. ( PubMed , DOI )

  3. Oyama K#, Ohara S#, Sato S, Karube F, Fujiyama F, Isomura Y, Mushiake H, Iijima T, *Tsutsui KI: Long-lasting single-neuron labeling by in vivo electroporation without microscopic guidance. Journal of Neuroscience Methods. 2013.09; 218 (2): 139-147. ( DOI )

  4. Riichiro Hira, Fuki Ohkubo, Yasuhiro R Tanaka, Yoshito Masamizu, George J Augustine, Haruo Kasai, Masanori Matsuzaki: In vivo optogenetic tracing of functional corticocortical connections between motor forelimb areas. Front Neural Circuits. 2013.04; 7 55. ( PubMed , DOI )

  5. *Tsubo Y, Isomura Y, Fukai T: Passage-time coding with timing kernel inferred from irregular cortical spike sequences. J Stat Mech Theor Exp (JSTAT). 2013.03; 2013 (3): P03004. ( DOI )

  6. Hira R, Ohkubo F, Ozawa K, Isomura Y, Kitamura K, Kano M, Kasai H, *Matsuzaki M: Spatiotemporal Dynamics of Functional Clusters of Neurons in the Mouse Motor Cortex during a Voluntary Movement. The Journal of Neuroscience. 2013.01; 33 (4): 1377-1390. ( PubMed , DOI )

  1. *Tsubo Y, Isomura Y, Fukai T: Power-law inter-spike interval distributions infer a conditional maximization of entropy in cortical neurons. PLoS Computational Biology. 2012.04; 8 (4): e1002461. ( PubMed , DOI )

  2. Takekawa T, Isomura Y, *Fukai T: Spike sorting of heterogeneous neuron types by multimodality-weighted PCA and explicit robust variational Bayes. Frontiers in Neuroinformatics. 2012.03; 6 article 5. ( PubMed , DOI )

  1. Rie Ako, Mayu Wakimoto, Haruka Ebisu, Kaori Tanno, Riichiro Hira, Haruo Kasai, Masanori Matsuzaki, Hiroshi Kawasaki: Simultaneous visualization of multiple neuronal properties with single-cell resolution in the living rodent brain. Mol. Cell. Neurosci.. 2011.11; 48 (3): 246-257. ( PubMed , DOI )

  2. Kazuo Ito, Kyohei Fujita: In vitro analysis of mouse mesencephalic neural crest development. Curr Protoc Neurosci. 2011.07; Chapter 3 Unit 3.23. ( PubMed , DOI )

  3. Kyohei Fujita, Saki Yasui, Takeshi Shinohara, Kazuo Ito: Interaction between NF-κB signaling and Notch signaling in gliogenesis of mouse mesencephalic neural crest cells. Mech Dev. 2011; 128 (7-10): 496-509. ( PubMed , DOI )

  1. Fujiwara-Tsukamoto Y, *Isomura Y, Imanishi M, Ninomiya T, Tsukada M, Yanagawa Y, Fukai T, Takada M: Prototypic seizure activity driven by mature hippocampal fast-spiking interneurons. The Journal of Neuroscience. 2010.10; 30 (41): 13679-13689. ( PubMed , DOI )

  1. Li L, Saegusa H, Tanabe T: Deficit of heat shock transcription factor 1-heat shock 70 kDa protein 1A axis determines the cell death vulnerability in a model of spinocerebellar ataxia type 6. Genes Cells. 2009.11; 14 (11): 1253-1269. ( PubMed , DOI )

  2. Kondo D, Saegusa H, Yabe R, Takasaki I, Kurihara T, Zong S, Tanabe T: Peripheral-type benzodiazepine receptor antagonist is effective in relieving neuropathic pain in mice. J Pharmacol Sci. 2009.05; 110 (1): 55-63. ( PubMed )

  3. Riichiro Hira, Naoki Honkura, Jun Noguchi, Yoshio Maruyama, George J Augustine, Haruo Kasai, Masanori Matsuzaki: Transcranial optogenetic stimulation for functional mapping of the motor cortex. J. Neurosci. Methods. 2009.05; 179 (2): 258-263. ( PubMed , DOI )

  4. Okamoto N, Yamanaka N, Satake H, Saegusa H, Kataoka H, Mizoguchi A: An ecdysteroid-inducible insulin-like growth factor-like peptide regulates adult development of the silkmoth Bombyx mori. FEBS J. 2009.03; 276 (5): 1221-1232. ( PubMed , DOI )

  5. Sakurai E, Kurihara T, Kouchi K, Saegusa H, Zong S, Tanabe T: Upregulation of casein kinase 1epsilon in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain. Mol Pain. 2009; 5 74. ( PubMed , DOI )

  1. Atsushi Ohsaga, Yoshimichi Murata, Yoshiaki Kondo, Riichiro Hira, Yoshio Maruyama: Asymmetry of Rb+ conduction emerged under bi-ionic conditions in epithelial maxi-K+ channels. J Physiol Sci. 2008.12; 58 (6): 363-369. ( PubMed , DOI )

  2. Mariko Itoh, Kyohei Fujita, Kohei Hatta: A sleep disorder in zebrafish: analysis of a population that spawn before dawn Reports of graduate school of material science and graduate school of life science. 2008; (19): 19-28.

  1. Saegusa H, Wakamori M, Matsuda Y, Wang J, Mori Y, Zong S, Tanabe T: Properties of human Cav2.1 channel with a spinocerebellar ataxia type 6 mutation expressed in Purkinje cells. Mol Cell Neurosci. 2007.02; 34 (2): 261-270. ( PubMed , DOI )

  1. Kondo D, Yabe R, Kurihara T, Saegusa H, Zong S, Tanabe T: Progesterone receptor antagonist is effective in relieving neuropathic pain. Eur J Pharmacol. 2006.07; 541 (1-2): 44-48. ( PubMed , DOI )

  2. Osanai M, Saegusa H, Kazuno AA, Nagayama S, Hu Q, Zong S, Murakoshi T, Tanabe T: Altered cerebellar function in mice lacking CaV2.3 Ca2+ channel. Biochem Biophys Res Commun. 2006.06; 344 (3): 920-925. ( PubMed , DOI )

  1. Takasaki I, Kurihara T, Saegusa H, Zong S, Tanabe T: Effects of glucocorticoid receptor antagonists on allodynia and hyperalgesia in mouse model of neuropathic pain. Eur J Pharmacol. 2005.11; 524 (1-3): 80-83. ( PubMed , DOI )

  2. Hu Q, Saegusa H, Hayashi Y, Tanabe T: The carboxy-terminal tail region of human Cav2.1 (P/Q-type) channel is not an essential determinant for its subcellular localization in cultured neurones. Genes Cells. 2005.02; 10 (2): 87-96. ( PubMed , DOI )

  1. Yokoyama K, Kurihara T, Saegusa H, Zong S, Makita K, Tanabe T: Blocking the R-type (Cav2.3) Ca2+ channel enhanced morphine analgesia and reduced morphine tolerance. Eur J Neurosci. 2004.12; 20 (12): 3516-3519. ( PubMed , DOI )

  1. Takei T, Saegusa H, Zong S, Murakoshi T, Makita K, Tanabe T: Increased sensitivity to halothane but decreased sensitivity to propofol in mice lacking the N-type Ca2+ channel. Neurosci Lett. 2003.10; 350 (1): 41-45. ( PubMed )

  2. Takei T, Saegusa H, Zong S, Murakoshi T, Makita K, Tanabe T: Anesthetic sensitivities to propofol and halothane in mice lacking the R-type (Cav2.3) Ca2+ channel. Anesth Analg. 2003.07; 97 (1): 96-103, table of contents. ( PubMed )

  1. Han W, Saegusa H, Zong S, Tanabe T: Altered cocaine effects in mice lacking Ca(v)2.3 (alpha(1E)) calcium channel. Biochem Biophys Res Commun. 2002.11; 299 (2): 299-304. ( PubMed )

  2. Saegusa H, Matsuda Y, Tanabe T: Effects of ablation of N- and R-type Ca(2+) channels on pain transmission. Neurosci Res. 2002.05; 43 (1): 1-7. ( PubMed )

  3. Sakata Y, Saegusa H, Zong S, Osanai M, Murakoshi T, Shimizu Y, Noda T, Aso T, Tanabe T: Ca(v)2.3 (alpha1E) Ca2+ channel participates in the control of sperm function. FEBS Lett. 2002.04; 516 (1-3): 229-233. ( PubMed )

  4. Tsunemi T, Saegusa H, Ishikawa K, Nagayama S, Murakoshi T, Mizusawa H, Tanabe T: Novel Cav2.1 splice variants isolated from Purkinje cells do not generate P-type Ca2+ current. J Biol Chem. 2002.03; 277 (9): 7214-7221. ( PubMed , DOI )

  5. Toriyama H, Wang L, Saegusa H, Zong S, Osanai M, Murakoshi T, Noda T, Ohno K, Tanabe T: Role of Ca(v) 2.3 (alpha1E ) Ca2+ channel in ischemic neuronal injury. Neuroreport. 2002.02; 13 (2): 261-265. ( PubMed )

  1. Matsuda Y, Saegusa H, Zong S, Noda T, Tanabe T: Mice lacking Ca(v)2.3 (alpha1E) calcium channel exhibit hyperglycemia. Biochem Biophys Res Commun. 2001.12; 289 (4): 791-795. ( PubMed , DOI )

  2. Sakata Y, Saegusa H, Zong S, Osanai M, Murakoshi T, Shimizu Y, Noda T, Aso T, Tanabe T: Analysis of Ca(2+) currents in spermatocytes from mice lacking Ca(v)2.3 (alpha(1E)) Ca(2+) channel. Biochem Biophys Res Commun. 2001.11; 288 (4): 1032-1036. ( PubMed , DOI )

  3. Saegusa H, Kurihara T, Zong S, Kazuno A, Matsuda Y, Nonaka T, Han W, Toriyama H, Tanabe T: Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel. EMBO J. 2001.05; 20 (10): 2349-2356. ( PubMed , DOI )

  4. Kubota M, Murakoshi T, Saegusa H, Kazuno A, Zong S, Hu Q, Noda T, Tanabe T: Intact LTP and fear memory but impaired spatial memory in mice lacking Ca(v)2.3 (alpha(IE)) channel. Biochem Biophys Res Commun. 2001.03; 282 (1): 242-248. ( PubMed , DOI )

  1. Masumura M, Satake S, Saegusa H, Mizoguchi A: Glucose stimulates the release of bombyxin, an insulin-related peptide of the silkworm Bombyx mori. Gen Comp Endocrinol. 2000.06; 118 (3): 393-399. ( PubMed , DOI )

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  1. Kamijo TC, Hayakawa H, Fukushima Y, Kubota Y, Isomura Y, Tsukada M, Aihara T: Input integration around the dendritic branches in hippocampal dentate granule cells. Cognitive Neurodynamics. 2014.08; 8 267-276. ( PubMed , DOI )

  1. Isomura Y, Takekawa T, Harukuni R, Handa T, Aizawa H, Takada M, Fukai T: Reward-modulated motor information in identified striatum neurons. The Journal of Neuroscience. 2013.06; 33 10209-10220. ( PubMed , DOI )

  2. Tsubo Y, Isomura Y, Fukai T: Neural dynamics and information representation in microcircuits of motor cortex. Frontiers in Neural Circuits. 2013.05; 7 85. ( PubMed , DOI )

  3. Aizawa H, Yanagihara S, Kobayashi M, Niisato K, Takekawa T, Harukuni R, McHugh TJ, Fukai T, Isomura Y, Okamoto H: The synchronous activity of lateral habenular neurons is essential for regulating hippocampal theta oscillation. The Journal of Neuroscience. 2013.05; 33 (20): 8909-8921. ( DOI )

  1. Kimura R, Saiki A, Fujiwara-Tsukamoto Y, Ohkubo F, Kitamura K, Matsuzaki M, Sakai Y, Isomura Y: Reinforcing operandum: rapid and reliable learning of skilled forelimb movements by head-fixed rodents. Journal of Neurophysiology. 2012.09; 108 1781-1792. ( PubMed , DOI )

  1. Safonov LA, Isomura Y, Kang S, Struzik ZR, Fukai T, Câteau H: Near scale-free dynamics in neural population activity of waking/sleeping rats revealed by multiscale analysis. PloS ONE. 2010.09; 5 ( PubMed , DOI )

  2. Tsujimoto T, Shimazu H, Isomura Y, Sasaki K: Theta oscillations in primate prefrontal and anterior cingulate cortices in forewarned reaction time tasks. Journal of Neurophysiology. 2010.02; 103 (2): 827-843. ( PubMed , DOI )

  3. Takekawa T, Isomura Y, Fukai T: Accurate spike sorting for multi-unit recordings. The European Journal of Neuroscience. 2010.01; 31 263-272. ( PubMed , DOI )

  1. Isomura Y, Harukuni R, Takekawa T, Aizawa H, Fukai T: Microcircuitry coordination of cortical motor information in self-initiation of voluntary movements. Nature Neuroscience. 2009.12; 12 (12): 1586-1593. ( PubMed , DOI )

  2. Tsujimoto T, Mima T, Shimazu H, Isomura Y: Directional organization of sensorimotor oscillatory activity related to the electromyogram in the monkey. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2009.06; 120 1168-1173. ( PubMed , DOI )

  3. Ishida Y, Kozaki T, Isomura Y, Ito S, Isobe K: Age-dependent changes in dopaminergic neuron firing patterns in substantia nigra pars compacta. Journal of neural transmission. Supplementum. 2009; 129-133. ( PubMed , DOI )

  1. Sirota A, Montgomery S, Fujisawa S, Isomura Y, Zugaro M, Buzsáki G: Entrainment of neocortical neurons and gamma oscillations by the hippocampal theta rhythm. Neuron. 2008.11; 60 (4): 683-697. ( PubMed , DOI )

  2. Isomura Y, Fujiwara-Tsukamoto Y, Takada M: A network mechanism underlying hippocampal seizure-like synchronous oscillations. Neuroscience research. 2008.07; 61 (3): 227-233. ( PubMed , DOI )

  1. Okamoto H, Isomura Y, Takada M, Fukai T: Temporal integration by stochastic recurrent network dynamics with bimodal neurons. Journal of neurophysiology. 2007.06; 97 3859-3867. ( PubMed , DOI )

  2. Fujiwara-Tsukamoto Y, Isomura Y, Imanishi M, Fukai T, Takada M: Distinct types of ionic modulation of GABA actions in pyramidal cells and interneurons during electrical induction of hippocampal seizure-like network activity. The European journal of neuroscience. 2007.05; 25 2713-2725. ( PubMed , DOI )

  1. Isomura Y, Sirota A, Ozen S, Montgomery S, Mizuseki K, Henze DA, Buzsáki G: Integration and segregation of activity in entorhinal-hippocampal subregions by neocortical slow oscillations. Neuron. 2006.12; 52 (5): 871-882. ( PubMed , DOI )

  2. Tsujimoto T, Shimazu H, Isomura Y: Direct recording of theta oscillations in primate prefrontal and anterior cingulate cortices. Journal of neurophysiology. 2006.05; 95 2987-3000. ( PubMed , DOI )

  3. Fujiwara-Tsukamoto Y, Isomura Y, Takada M: Comparable GABAergic mechanisms of hippocampal seizurelike activity in posttetanic and low-Mg2+ conditions. Journal of neurophysiology. 2006.03; 95 2013-2019. ( PubMed , DOI )

  1. Kaneda K, Fujiwara-Tsukamoto Y, Isomura Y, Takada M: Region-specific modulation of electrically induced synchronous oscillations in the rat hippocampus and cerebral cortex. Neuroscience research. 2005.05; 52 (1): 83-94. ( PubMed , DOI )

  1. Fujiwara-Tsukamoto Y, Isomura Y, Kaneda K, Takada M: Synaptic interactions between pyramidal cells and interneurone subtypes during seizure-like activity in the rat hippocampus. The Journal of physiology. 2004.06; 557 961-979. ( PubMed , DOI )

  2. Isomura Y, Takada M: Neural mechanisms of versatile functions in primate anterior cingulate cortex. Reviews in the neurosciences. 2004; 15 279-291. ( PubMed )

  1. Tsujimoto T, Shimazu H, Isomura Y, Sasaki K: Prefrontal theta oscillations associated with hand movements triggered by warning and imperative stimuli in the monkey. Neuroscience letters. 2003.11; 351 103-106. ( PubMed , DOI )

  2. Isomura Y, Sugimoto M, Fujiwara-Tsukamoto Y, Yamamoto-Muraki S, Yamada J, Fukuda A: Synaptically activated Cl- accumulation responsible for depolarizing GABAergic responses in mature hippocampal neurons. Journal of neurophysiology. 2003.10; 90 2752-2756. ( PubMed , DOI )

  3. Isomura Y, Fujiwara-Tsukamoto Y, Takada M: Glutamatergic propagation of GABAergic seizure-like afterdischarge in the hippocampus in vitro. Journal of neurophysiology. 2003.10; 90 2746-2751. ( PubMed , DOI )

  4. Isomura Y, Ito Y, Akazawa T, Nambu A, Takada M: Neural coding of "attention for action" and "response selection" in primate anterior cingulate cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003.09; 23 8002-8012. ( PubMed )

  5. Fujiwara-Tsukamoto Y, Isomura Y, Nambu A, Takada M: Excitatory GABA input directly drives seizure-like rhythmic synchronization in mature hippocampal CA1 pyramidal cells. Neuroscience. 2003; 119 265-275. ( PubMed , DOI )

  1. Isomura Y, Fujiwara-Tsukamoto Y, Imanishi M, Nambu A, Takada M: Distance-dependent Ni(2+)-sensitivity of synaptic plasticity in apical dendrites of hippocampal CA1 pyramidal cells. Journal of neurophysiology. 2002.02; 87 1169-1174. ( PubMed )

  1. Isomura Y, Kato N: Possible regulatory role of dendritic spikes in induction of long-term potentiation at hippocampal schaffer collateral-CA1 synapses. Brain research. 2000.11; 883 (1): 119-124. ( PubMed , DOI )

  2. Kato N, Isomura Y, Tanaka T: Intracellular calcium releases facilitate induction of long-term depression. Neuropharmacology. 2000.04; 39 (6): 1107-1110. ( PubMed , DOI )

  3. Yamamoto K, Hashimoto K, Isomura Y, Shimohama S, Kato N: An IP3-assisted form of Ca2+-induced Ca2+ release in neocortical neurons. Neuroreport. 2000.02; 11 535-539. ( PubMed )

  1. Isomura Y, Kato N: Action potential-induced dendritic calcium dynamics correlated with synaptic plasticity in developing hippocampal pyramidal cells. Journal of neurophysiology. 1999.10; 82 1993-1999. ( PubMed )

  2. Kato N, Tanaka T, Yamamoto K, Isomura Y: Distinct temporal profiles of activity-dependent calcium increase in pyramidal neurons of the rat visual cortex. The Journal of physiology. 1999.09; 519 Pt 2 467-479. ( PubMed , DOI )

  3. Hashimoto K, Isomura Y, Kato N: Occurrence of dentate granule cell LTP without proximal dendritic Ca2+ increase. Neuroreport. 1999.08; 10 2509-2513. ( PubMed )

  4. Isomura Y, Hashimoto K, Yamamoto K, Kato N: Developmental regulation of action potential-induced Ca2+ entry in neocortical neurons. Neuroreport. 1999.06; 10 1947-1950. ( PubMed )

  5. Kato N, Tanaka T, Yamamoto K, Isomura Y: Enhancement of activity-dependent calcium increase by neurotrophin-4 in visual cortex pyramidal neurons. Brain research. 1999.06; 832 (1/2): 179-183. ( PubMed , DOI )

  6. Isomura Y, Yamamoto K, Hashimoto K, Kato N: Postnatal development of action potential-induced dendritic calcium entry in neocortical layer II/III pyramidal cells. Brain research. 1999.06; 832 (1/2): 175-178. ( PubMed , DOI )

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