1. Ono D, Kawai H, Kuwahara H, Yokota T: Automated whole slide morphometry of sural nerve biopsy using machine learning. Neuropathology and applied neurobiology. 2024.04; 50 (2): e12967. ( PubMed , DOI )

  2. Amano E, Sato W, Kimura Y, Kimura A, Lin Y, Okamoto T, Sato N, Yokota T, Yamamura T: CD11c(high) B Cell Expansion Is Associated With Severity and Brain Atrophy in Neuromyelitis Optica. Neurology(R) neuroimmunology & neuroinflammation. 2024.03; 11 (2): e200206. ( PubMed , DOI )

  3. Hiroyuki Maruoka, Takaaki Hattori, Takeshi Hase, Kunihiko Takahashi, Masahiro Ohara, Satoshi Orimo, Takanori Yokota: Aberrant morphometric networks in Alzheimer's disease have hemispheric asymmetry and age dependence. Eur J Neurosci. 2024.03; 59 (6): 1332-1347. ( PubMed , DOI )

  4. Nishina K, Yoshioka K, Yokota T, Hara RI: Comparison of interaction between antimiR and microRNA versus HDO-antimiR and microRNA by molecular dynamics simulation. Nucleosides, nucleotides & nucleic acids. 2024.01; 1-16. ( PubMed , DOI )

  5. Sanjo N, Suzuki M, Yoshihama R, Toyoshima Y, Mizuta I, Fujita N, Usuda H, Uchiyama Y, Yasuda R, Yoshida T, Yamada M, Yokota T: Substitution of Glu to Lys at Codon 332 on the GFAP Gene Alone Is Causative for Adult-onset Alexander Disease. Internal medicine (Tokyo, Japan). 2024.01; 63 (2): 309-313. ( PubMed , DOI )

  6. Okamoto T, Ishizuka T, Shimizu R, Asahina Y, Nakamura H, Shimizu Y, Nishida Y, Yokota T, Lin Y, Sato W, Yamamura T: Efficacy and Safety of the Natural Killer T Cell-Stimulatory Glycolipid OCH-NCNP1 for Patients With Relapsing Multiple Sclerosis: Protocol for a Randomized Placebo-Controlled Clinical Trial. JMIR research protocols. 2024.01; 13 e46709. ( PubMed , DOI )

  7. Yum J, Aulia F, Kamiya K, Hori M, Qiao N, Kim BS, Naito M, Ogura S, Nagata T, Yokota T, Uchida S, Obika S, Kim HJ, Miyata K: Hydrophobicity Tuning of Cationic Polyaspartamide Derivatives for Enhanced Antisense Oligonucleotide Delivery. Bioconjugate chemistry. 2024.01; 35 (2): 125-131. ( PubMed , DOI )

  1. Kawai H, Matsubayashi T, Yokota T, Sanjo N: Serial changes in regional cerebral blood flow in Gerstmann-Sträussler-Scheinker disease caused by a Pro-to-Leu mutation at codon 105 in the prion protein gene. Prion. 2023.12; 17 (1): 138-140. ( PubMed , DOI )

  2. Hirata K, Matsuoka K, Tagai K, Endo H, Tatebe H, Ono M, Kokubo N, Oyama A, Shinotoh H, Takahata K, Obata T, Dehghani M, Near J, Kawamura K, Zhang MR, Shimada H, Yokota T, Tokuda T, Higuchi M, Takado Y: Altered Brain Energy Metabolism Related to Astrocytes in Alzheimer's Disease. Annals of neurology. 2023.09; ( PubMed , DOI )

  3. Noda K, Hattori Y, Hori M, Nakaoku Y, Tanaka A, Yoshimoto T, Nishimura K, Yokota T, Harada-Shiba M, Ihara M: Amplified Risk of Intracranial Artery Stenosis/Occlusion Associated With RNF213 p.R4810K in Familial Hypercholesterolemia. JACC. Asia. 2023.08; 3 (4): 625-633. ( PubMed , DOI )

  4. Iida S, Kanouchi T, Hattori T, Kanai K, Nakazato T, Hattori N, Yokota T: Verification of propagation hypothesis in patients with sporadic hand onset amyotrophic lateral sclerosis. Acta neurologica Belgica. 2023.08; 123 (4): 1511-1517. ( PubMed , DOI )

  5. Yuhei Takahashi, Kiyoshi Kakuta, Yukichi Namioka, Ayumi Igarashi, Taiichi Sakamoto, Rintaro Iwata Hara, Kazuki Sato, Takeshi Wada: Synthesis of P-Modified DNA from Boranophosphate DNA as a Precursor via Acyl Phosphite Intermediates The Journal of Organic Chemistry. 2023.07; 88 (15): 10617-10631. ( DOI )

  6. Motoki Miura, Fumika Sakaue, Hirokazu Matsuno, Kento Morita, Akiko Yoshida, Rintaro Iwata Hara, Ren Nishimura, Yurika Nishida, Mariko Yokogawa, Masanori Osawa, Takanori Yokota: TDP‐43 N‐terminal domain dimerisation or spatial separation by RNA binding decreases its propensity to aggregate FEBS Letters. 2023.06; 597 (12): 1667-1676. ( DOI )

  7. Mitsui J, Matsukawa T, Uemura Y, Kawahara T, Chikada A, Porto KJL, Naruse H, Tanaka M, Ishiura H, Toda T, Kuzuyama H, Hirano M, Wada I, Ga T, Moritoyo T, Takahashi Y, Mizusawa H, Ishikawa K, Yokota T, Kuwabara S, Sawamoto N, Takahashi R, Abe K, Ishihara T, Onodera O, Matsuse D, Yamasaki R, Kira JI, Katsuno M, Hanajima R, Ogata K, Takashima H, Matsushima M, Yabe I, Sasaki H, Tsuji S: High-dose ubiquinol supplementation in multiple-system atrophy: a multicentre, randomised, double-blinded, placebo-controlled phase 2 trial. EClinicalMedicine. 2023.05; 59 101920. ( PubMed , DOI )

  8. Kazuki Sato, Kazumasa Muramoto, Tomoya Hagio, Rintaro I. Hara, Takeshi Wada: Solid-Phase Synthesis of Glycosyl Phosphate Repeating Units via Glycosyl Boranophosphates as Stable Intermediates Organic Letters. 2023.05; 25 (21): 3927-3931. ( DOI )

  9. Nakamura R, Tohnai G, Nakatochi M, Atsuta N, Watanabe H, Ito D, Katsuno M, Hirakawa A, Izumi Y, Morita M, Hirayama T, Kano O, Kanai K, Hattori N, Taniguchi A, Suzuki N, Aoki M, Iwata I, Yabe I, Shibuya K, Kuwabara S, Oda M, Hashimoto R, Aiba I, Ishihara T, Onodera O, Yamashita T, Abe K, Mizoguchi K, Shimizu T, Ikeda Y, Yokota T, Hasegawa K, Tanaka F, Nakashima K, Kaji R, Niwa JI, Doyu M, Terao C, Ikegawa S, Fujimori K, Nakamura S, Ozawa F, Morimoto S, Onodera K, Ito T, Okada Y, Okano H, Sobue G, Japanese Consortium for Amyotrophic Lateral Sclerosis research (JaCALS) study group: Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients. Journal of neurology, neurosurgery, and psychiatry. 2023.05; 94 (10): 816-824. ( PubMed , DOI )

  10. Honda T, Matsumura K, Hashimoto Y, Yokota T, Mizusawa H, Nagao S, Ishikawa K: Temporal Relationship between Impairment of Cerebellar Motor Learning and Deterioration of Ataxia in Patients with Cerebellar Degeneration. Cerebellum (London, England). 2023.04; ( PubMed , DOI )

  11. Yanagidaira M, Yoshioka K, Nagata T, Nakao S, Miyata K, Yokota T: Effects of combinations of gapmer antisense oligonucleotides on the target reduction. Molecular biology reports. 2023.04; 50 (4): 3539-3546. ( PubMed , DOI )

  12. Li F, Ichinose K, Ishibashi S, Yamamoto S, Iwasawa E, Suzuki M, Yoshida-Tanaka K, Yoshioka K, Nagata T, Hirabayashi H, Mogushi K, Yokota T: Preferential delivery of lipid-ligand conjugated DNA/RNA heteroduplex oligonucleotide to ischemic brain in hyperacute stage. Molecular therapy : the journal of the American Society of Gene Therapy. 2023.04; 31 (4): 1106-1122. ( PubMed , DOI )

  13. Miyashita A, Kobayashi M, Yokota T, Zochodne DW: Diabetic Polyneuropathy: New Strategies to Target Sensory Neurons in Dorsal Root Ganglia. International journal of molecular sciences. 2023.03; 24 (6): ( PubMed , DOI )

  14. Jia C, Lei Mon SS, Yang Y, Katsuyama M, Yoshida-Tanaka K, Nagata T, Yoshioka K, Yokota T: Change of intracellular calcium level causes acute neurotoxicity by antisense oligonucleotides via CSF route. Molecular therapy. Nucleic acids. 2023.03; 31 182-196. ( PubMed , DOI )

  15. Ohara M, Hirata K, Hallett M, Matsubayashi T, Chen Q, Kina S, Shimano K, Hirakawa A, Yokota T, Hattori T: Long-term levodopa ameliorates sequence effect in simple, but not complex walking in early Parkinson's disease patients. Parkinsonism & related disorders. 2023.03; 108 105322. ( PubMed , DOI )

  16. Tomomi Shiraishi, Kazuki Sato, Rintaro Iwata Hara, Takeshi Wada: Properties of artificial cationic oligodiaminosaccharides and oligopeptides that bind to A-type oligonucleotide duplexes Nucleosides, Nucleotides & Nucleic Acids. 2023.02; 619-636. ( DOI )

  17. Amano A, Sanjo N, Araki W, Anraku Y, Nakakido M, Matsubara E, Tomiyama T, Nagata T, Tsumoto K, Kataoka K, Yokota T: Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain. Journal of nanobiotechnology. 2023.01; 21 (1): 36. ( PubMed , DOI )

  18. Takaaki Koide, Shintaro Mandai*, Reo Kitaoka, Hisazumi Matsuki, Motoko Chiga, Kouhei Yamamoto, Kotaro Yoshioka, Yohsuke Yagi, Soichiro Suzuki, Tamami Fujiki, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Shotaro Naito, Eisei Sohara, Tatemitsu Rai, Takanori Yokota, Shinichi Uchida: Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease. Circ Res. 2023.01; ( PubMed , DOI )

  19. Hattori T, Ohara M, Yuasa T, Azuma R, Chen Q, Hanazawa R, Hirakawa A, Orimo S, Yokota T: Correlation of callosal angle at the splenium with gait and cognition in normal pressure hydrocephalus. Journal of neurosurgery. 2023.01; 139 (2): 1-11. ( PubMed , DOI )

  20. Aiba I, Hayashi Y, Shimohata T, Yoshida M, Saito Y, Wakabayashi K, Komori T, Hasegawa M, Ikeuchi T, Tokumaru AM, Sakurai K, Murayama S, Hasegawa K, Uchihara T, Toyoshima Y, Saito Y, Yabe I, Tanikawa S, Sugaya K, Hayashi K, Sano T, Takao M, Sakai M, Fujimura H, Takigawa H, Adachi T, Hanajima R, Yokota O, Miki T, Iwasaki Y, Kobayashi M, Arai N, Ohkubo T, Yokota T, Mori K, Ito M, Ishida C, Tanaka M, Idezuka J, Kanazawa M, Aoki K, Aoki M, Hasegawa T, Watanabe H, Hashizume A, Niwa H, Yasui K, Ito K, Washimi Y, Mukai E, Kubota A, Toda T, Nakashima K, J-VAC study group: Clinical course of pathologically confirmed corticobasal degeneration and corticobasal syndrome. Brain communications. 2023; 5 (6): fcad296. ( PubMed , DOI )

  1. Taiki Matsubayashi, Nobuo Sanjo: Systematic Review of Clinical and Pathophysiological Features of Genetic Creutzfeldt–Jakob Disease Caused by a Val-to-Ile Mutation at Codon 180 in the Prion Protein Gene International Journal of Molecular Science. 2022.12; 23 15172.

  2. Matsuda Hiroshi, Okita Kyoji, Motoi Yumiko, Mizuno Toshiki, Ikeda Manabu, Sanjo Nobuo, Murakami Koji, Kambe Taiki, Takayama Toshiki, Yamada Kei, Suehiro Takashi, Matsunaga Keiko, Yokota Takanori, Tateishi Ukihide, Shigemoto Yoko, Kimura Yukio, Chiba Emiko, Kawashima Takahiro, Tomo Yui, Tachimori Hisateru, Kimura Yuichi, Sato Noriko: Clinical impact of amyloid PET using 18F-florbetapir in patients with cognitive impairment and suspected Alzheimer's disease: a multicenter study Annals of Nuclear Medicine. 2022.12; 36 (12): 1039-1049. ( ichushi )

  3. Matsuda Hiroshi, Okita Kyoji, Motoi Yumiko, Mizuno Toshiki, Ikeda Manabu, Sanjo Nobuo, Murakami Koji, Kambe Taiki, Takayama Toshiki, Yamada Kei, Suehiro Takashi, Matsunaga Keiko, Yokota Takanori, Tateishi Ukihide, Shigemoto Yoko, Kimura Yukio, Chiba Emiko, Kawashima Takahiro, Tomo Yui, Tachimori Hisateru, Kimura Yuichi, Sato Noriko: Clinical impact of amyloid PET using F-18-florbetapir in patients with cognitive impairment and suspected Alzheimer's disease: a multicenter study ANNALS OF NUCLEAR MEDICINE. 2022.12; 36 (12): 1039-1049. ( PubMed , DOI )

  4. Masaaki Niino, Shoko Fukumoto, Tatsusada Okuno, Nobuo Sanjo, Hikoaki Fukaura, Masahiro Mori, Takashi Ohashi, Hideyuki Takeuchi, Yuko Shimizu, Juichi Fujimori, Izumi Kawachi, Jun-ichi Kira, Eri Takahashi, Yusei Miyazaki, Nobuhiro Mifune: Health related quality of life in Japanese patients with multiple sclerosis Journal of Neurology. 2022.11; 270 1011-1018.

  5. Ohara M, Sanjo N, Kanouchi T, Yokota T: Entrapment partly participates in the longitudinal progression of neuropathy with anti-MAG antibodies. Revue neurologique. 2022.11; 179 (1-2): 118-122. ( PubMed , DOI )

  6. Chen Q, Hattori T, Tomisato H, Ohara M, Hirata K, Yokota T, Alzheimer's Disease Neuroimaging Initiative: Turning and multitask gait unmask gait disturbance in mild-to-moderate multiple sclerosis: Underlying specific cortical thinning and connecting fibers damage. Human brain mapping. 2022.11; 44 (3): 1193-1208. ( PubMed , DOI )

  7. Goto A, Yamamoto S, Igari T, Matsumoto SI, Chisaki I, Iida K, Nakayama M, Oda A, Kakoi Y, Uchida A, Miyata K, Nishikawa M, Nagata T, Kusuhara H, Yokota T, Hirabayashi H: Quantitative Model Analysis and Simulation of Pharmacokinetics and Malat1 RNA Knockdown Effect After Systemic Administration of Cholesterol-conjugated DNA/RNA Heteroduplex Oligonucleotide Crossing Blood-Brain Barrier of Mice. The Journal of pharmacology and experimental therapeutics. 2022.10; 384 (1): 197-204. ( PubMed , DOI )

  8. Tomomi Shiraishi, Kazuki Sato, Rintaro Iwata Hara, Takeshi Wada: Synthesis and properties of oligodiaminogalactoses that bind to A-type oligonucleotide duplexes Organic & Biomolecular Chemistry. 2022.09; 20 (42): 8243-8258. ( DOI )

  9. Zeniya S, Sanjo N, Kuwahara H, Ishikawa K, Higashi M, Matsunaga A, Yoneda M, Mizusawa Ho, Yokota T: Spinocerebellar Ataxia Type 31 Exacerbated by Anti-amino Terminal of Alpha-enolase Autoantibodies(タイトル和訳中) Internal Medicine. 2022.09; 61 (18): 2793-2796. ( ichushi )

  10. Kazuki Sato, Akie Chiba, Tomomi Shiraishi, Yuki Ogawa, Rintaro Iwata Hara, Takeshi Wada: Solid-phase synthesis of N-trichloroacetyl mannosamine 1-phosphate repeating units mimicking capsular polysaccharide derived from Neisseria meningitidis serotype A Carbohydrate Research. 2022.08; 518 108585. ( DOI )

  11. Yokote H, Miyazaki Y, Toru S, Nishida Y, Hattori T, Niino M, Sanjo N, Yokota T: High-efficacy therapy reduces subcortical grey matter volume loss in Japanese patients with relapse-onset multiple sclerosis: A 2-year cohort study. Mult Scler Relat Disord. 2022.07; 67 104077. ( PubMed , DOI )

  12. Winklehner M, Bauer J, Endmayr V, Schwaiger C, Ricken G, Motomura M, Yoshimura S, Shintaku H, Ishikawa K, Tsuura Y, Iizuka T, Yokota T, Irioka T, Höftberger R: Paraneoplastic Cerebellar Degeneration With P/Q-VGCC vs Yo Autoantibodies. Neurology(R) neuroimmunology & neuroinflammation. 2022.07; 9 (4): e200006. ( PubMed , DOI )

  13. Toshitaka Yoshii, Takashi Hirai, Satoru Egawa, Motonori Hashimoto, Yu Matsukura, Hiroyuki Inose, Nobuo Sanjo, Takanori Yokota, Atsushi Okawa: Case Report: Dural Dissection With Ventral Spinal Fluid-Filled Collection in Superficial Siderosis: Insights Into the Pathology From Anterior-Approached Surgical Cases. Front Neurol. 2022.07; 13 919280. ( PubMed , DOI )

  14. Kaburagi Hidetoshi, Nagata Tetsuya, Enomoto Mitsuhiro, Hirai Takashi, Ohyagi Masaki, Ihara Kensuke, Yoshida-Tanaka Kie, Ebihara Satoe, Asada Ken, Yokoyama Hiroyuki, Okawa Atsushi, Yokota Takanori: Systemic DNA/RNA heteroduplex oligonucleotide administration for regulating the gene expression of dorsal root ganglion and sciatic nerve MOLECULAR THERAPY-NUCLEIC ACIDS. 2022.06; 28 910-919. ( PubMed , DOI )

  15. Tamaki Kana, Nishida Yoichiro, Sanjo Nobuo, Yokota Takanori: A patient with generalized myasthenia gravis facing an impending crisis triggered by early fast-acting treatment(タイトル和訳中) Clinical and Experimental Neuroimmunology. 2022.05; 13 (2): 99-101. ( ichushi )

  16. Kana Tamaki,Yoichiro Nishida,Nobuo Sanjo,Takanori Yokota: A patient with generalized myasthenia gravis facing an impending crisis triggered by early fast-acting treatment Clinical and Experimental Neuroimmunology. 2022.05; 13 99-101. ( DOI )

  17. Ryo Iwase, Tadashi Kanouchi, Toshitaka Yoshii, Taro Ishiguro, Takashi Hirai, Atsushi Okawa, Takanori Yokota, Nobuo Sanjo: Diverging pathophysiology in superficial siderosis with proximal upper limb amyotrophy. J Neurol Sci. 2022.05; 436 120248. ( PubMed , DOI )

  18. Noda Kotaro, Nosaka Nobuyuki, Hara Nobuhiro, Yokota Takanori, Shigemitsu Hidenobu, Takahashi Hideo: We Should Pay Attention to "Referred Pain": A Case of Acute Myocardial Infarction That Masked and Delayed the Diagnosis of Esophageal Perforation(和訳中) Internal Medicine. 2022.04; 61 (8): 1295-1298. ( ichushi )

  19. Bannawongsil T, Yamada A, Nakamura A, Uchihara T, Yokota T: Neuronal internalization of immunoglobulin G injected into the mouse brain by a novel absorption strategy to avoid unwanted interaction with immune complex using centrifugal filtration. Histochemistry and cell biology. 2022.04; ( PubMed , DOI )

  20. Uematsu M, Mikami K, Nakamura A, Takahashi R, Yokota T, Hirokawa K, Uchihara T: Parallel gold enhancement of quantum dots 565/655 for double-labelling correlative light and electron microscopy on human autopsied samples. Sci Rep. 2022.04; 12 (1): 6113. ( PubMed , DOI )

  21. Yamada Akane, Nishida Yoichiro, Wake Kenjiro, Nakamura Ayako, Sakamaki Yuriko, Kuwahara Hiroya, Uchihara Toshiki, Yokota Takanori: Serial ultrathin sections to identify ultrastructural localization of GLUT1 molecules in vesicles in brain endothelial cells-correlative light and electron microscopy in depth(和訳中) Microscopy. 2022.04; 71 (2): 124-131. ( ichushi )

  22. Matsubayashi T, Akaza M, Hayashi Y, Hamaguchi T, Satoh K, Kosami K, Ae R, Kitamoto T, Yamada M, Shimohata T, Yokota T, Sanjo N: Specific electroencephalogram features in the very early phases of sporadic Creutzfeldt-Jakob disease. J Neurol Sci. 2022.04; 437 120265. ( PubMed , DOI )

  23. Koki Kosami, Ryusuke Ae, Tsuyoshi Hamaguchi, Nobuo Sanjo, Tadashi Tsukamoto, Tetsuyuki Kitamoto, Masahito Yamada, Hidehiro Mizusawa, Yosikazu Nakamura: Methionine homozygosity for PRNP polymorphism and susceptibility to human prion diseases Journal of Neurology, Neurosurgery, and Psychiatry. 2022.04; 93 779-784.

  24. Miyashita A, Kobayashi M, Ishibashi S, Nagata T, Chandrasekahr A, Zochodne DW, Yokota T: The Role of Long Non-coding RNA MALAT1 in Diabetic Polyneuropathy and the Impact of its Silencing in the Dorsal Root Ganglion by a DNA/RNA Heteroduplex Oligonucleotide. Diabetes. 2022.03; 71 (6): 1299-1312. ( PubMed , DOI )

  25. Taniguchi K, Yamamoto F, Amamo A, Tamaoka A, Sanjo N, Yokota T, Kametani F, Araki W: Amyloid-β oligomers interact with NMDA receptors containing GluN2B subunits and metabotropic glutamate receptor 1 in primary cortical neurons: Relevance to the synapse pathology of Alzheimer's disease. Neurosci Res. 2022.03; ( PubMed , DOI )

  26. Yamada A, Nishida Y, Wake K, Nakamura A, Sakamaki Y, Kuwahara H, Uchihara T, Yokota T: Serial ultrathin sections to identify ultrastructural localization of GLUT1 molecules in vesicles in brain endothelial cells-correlative light and electron microscopy in depth. Microscopy (Oxford, England). 2022.02; 71 (2): 124-131. ( PubMed , DOI )

  27. Nishi R, Ohyagi M, Nagata T, Mabuchi Y, Yokota T: Regulation of activated microglia and macrophages by systemically administered DNA/RNA heteroduplex oligonucleotides. Mol Ther. 2022.02; 30 (6): 2210-23. ( PubMed , DOI )

  28. Aoki H, Higashi M, Okita M, Ando N, Murayama S, Ishikawa K, Yokota T: Thymidine Kinase 2 and Mitochondrial Protein COX I in the Cerebellum of Patients with Spinocerebellar Ataxia Type 31 Caused by Penta-nucleotide Repeats (TTCCA)n. Cerebellum . 2022.01; 22 (1): 70-84. ( PubMed , DOI )

  29. Masaaki Niino, Shoko Fukumoto, Tatsusada Okuno, Nobuo Sanjo, Hikoaki Fukaura, Masahiro Mori, Takashi Ohashi, Hideyuki Takeuchi, Yuko Shimizu, Juichi Fujimori, Izumi Kawachi, Jun-ichi Kira, Eri Takahashi, Yusei Miyazaki, Nobuhiro Mifune: Correlation of the Symbol Digit Modalities Test with the Quality of Life and Depression in Japanese Patients with Multiple Sclerosis Multiple Sclerosis and Related Disorders. 2022.01; 57 103427.

  30. Yohsuke Yagi, Yutaro Asami, Mitsuki Kyoya, Takanori Yokota: Cerebral venous sinus thrombosis after mRNA-based COVID-19 vaccination. Neurol Sci. 2022.01; 43 (1): 41-43. ( PubMed , DOI )

  31. Zeniya S, Sanjo N, Kuwahara H, Ishikawa K, Higashi M, Matsunaga A, Yoneda M, Mizusawa H, Yokota T: Spinocerebellar Ataxia Type 31 Exacerbated by Anti-amino Terminal of Alpha-enolase Autoantibodies. Internal medicine (Tokyo, Japan). 2022; 61 (18): 2793-2796. ( PubMed , DOI )

  1. Masaki Ohyagi, Tetsuya Nagata,Kensuke Ihara, Kie Yoshida-Tanaka, Rieko Nishi, Haruka Miyata, Aya Abe,Yo Mabuchi, Chihiro Akazawa, Takanori Yokota: DNA/RNA heteroduplex oligonucleotide technology for regulating lymphocytes in vivo. Nat Commun. 2021.12; 12 (1): 7344. ( PubMed , DOI )

  2. Tohnai G, Nakamura R, Atsuta N, Nakatochi M, Hayashi N, Ito D, Watanabe H, Watanabe H, Katsuno M, Izumi Y, Taniguchi A, Kanai K, Morita M, Kano O, Kuwabara S, Oda M, Abe K, Aoki M, Aiba I, Okamoto K, Mizoguchi K, Ishihara T, Kawata A, Yokota T, Hasegawa K, Nagano I, Yabe I, Tanaka F, Kuru S, Hattori N, Nakashima K, Kaji R, Sobue G, Japanese Consortium for Amyotrophic Lateral Sclerosis Research (JaCALS).: Mutation screening of the DNAJC7 gene in Japanese patients with sporadic amyotrophic lateral sclerosis. Neurobiol Aging. 2021.12; 113 131-136. ( PubMed , DOI )

  3. Hiromasa Matsuda , Hiroaki Ito , Yohei Nukaga , Sho Uehara , Kazuki Sato , Rintaro Iwata Hara , Takeshi Wada: Solid-phase synthesis of oligouridine boranophosphates using the H-boranophosphonate method with 2′-O-(2-cyanoethoxymethyl) protection Tetrahedron Letters. 2021.12; 87 (21): 153526. ( DOI )

  4. Kotaro Noda, Yohsuke Yagi, Takanori Yokota: Evaluation of the risk factors predicting thrombotic complications associated with intravenous immunoglobulin therapy in neuroimmunological diseases. Neurol Sci. 2021.12; 42 (12): 5321-5326. ( PubMed , DOI )

  5. Eiichiro Amano, Tomokatsu Yoshida, Ikuko Mizuta, Jun Oyama, Shingo Sakashita, Syunsuke Ueyama, Akira Machida, Takanori Yokota: Activation of a Cryptic Splice Site of GFAP in a Patient With Adult-Onset Alexander Disease. Neurol Genet. 2021.12; 7 (6): e626. ( PubMed , DOI )

  6. Yoichiro Nishida,Taro Ishiguro, Takanori Yokota: Tap-Elicited Clonus of the Biceps and Triceps Brachii. JAMA Neurol. 2021.11; 79 (2): 194. ( PubMed , DOI )

  7. Hiromasa Matsuda, Erina Yoshida, Takaaki Shinoda, Kazuki Sato, Rintaro Iwata Hara, Takeshi Wada: Solution-phase synthesis of oligodeoxyribonucleotides using the H-phosphonate method with N-unprotected 5′-phosphite monomers RSC Advances. 2021.11; 11 (60): 38094-38107. ( DOI )

  8. Kokoro Ozaki, Takashi Irioka, Toshiki Uchihara, Akane Yamada, Ayako Nakamura, Takamasa Majima, Susumu Igarashi, Hiroshi Shintaku, Mayumi Yakeishi, Yukio Tsuura, Yasushi Okazaki, Kinya Ishikawa, Takanori Yokota: Neuropathology of SCA34 showing widespread oligodendroglial pathology with vacuolar white matter degeneration: a case study. Acta neuropathol commun. 2021.10; 9 (1): 172. ( PubMed , DOI )

  9. Yurie Nose, Ikuko Uwano, Ukihide Tateishi, Makoto Sasaki, Takanori Yokota, Nobuo Sanjo: Quantitative clinical and radiological recovery in post-operative patients with superficial siderosis by an iron chelator. J Neurol. 2021.10; 269 (5): 2539-2548. ( PubMed , DOI )

  10. Takayuki Kuroda, Miho Akaza, Kazunori Miki, Shoko Fujii, Yousuke Yagi, Tadashi Kanouchi, Nobuo Sanjo, Kazutaka Sumita, Takanori Yokota: Sacral dural arteriovenous fistula mimicking multiple mononeuropathy. Clin Neurol Neurosurg. 2021.10; 210 106993. ( PubMed , DOI )

  11. Noda K, Nosaka N, Hara N, Yokota T, Shigemitsu H, Takahashi H: We Should Pay Attention to "Referred Pain" - A Case of Acute Myocardial Infarction that Masked and Delayed the Diagnosis of Esophageal Perforation. Internal medicine (Tokyo, Japan). 2021.09; 61 (8): 1295-1298. ( PubMed , DOI )

  12. Rintaro Iwata Hara, Takeshi Wada: Inhibition of off-target cleavage by RNase H using an artificial cationic oligosaccharide. Org Biomol Chem. 2021.08; 19 (31): 6865-6870. ( PubMed , DOI )

  13. Tetsuya Nagata, Chrissa A. Dwyer, Kie Yoshida-Tanaka, Kensuke Ihara, Masaki Ohyagi, Hidetoshi Kaburagi, Haruka Miyata, Satoe Ebihara, Kotaro Yoshioka, Takashi Ishii, Kanjiro Miyata, Kenichi Miyata, Berit Powers, Tomoko Igari, Syunsuke Yamamoto, Naoto Arimura, Hideki Hirabayashi, Toshiki Uchihara, Rintaro Iwata Hara, Takeshi Wada, C. Frank Bennett, Punit P. Seth, Frank Rigo and Takanori Yokota: Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS. Nat Biotechnol. 2021.08; ( PubMed , DOI )

  14. Kazuki Sato, Tomoya Hagio, Michi Sano, Kazumasa Muramoto, Aya Yaoita, Mihoko Noro, Rintaro Iwata Hara, Takeshi Wada: Solid-Phase Stereocontrolled Synthesis of Oligomeric P-Modified Glycosyl Phosphate Derivatives Using the Oxazaphospholidine Method. ACS Omega. 2021.08; 6 (30): 20026-20041. ( PubMed , DOI )

  15. Kazumasa Kawata, Hideyuki Koga, Kunikazu Tsuji, Kazumasa Miyatake, Yusuke Nakagawa, Takanori Yokota, Ichiro Sekiya, Hiroki Katagiri: Extracellular vesicles derived from mesenchymal stromal cells mediate endogenous cell growth and migration via the CXCL5 and CXCL6/CXCR2 axes and repair menisci. Stem Cell Res Ther. 2021.07; 12 (1): 414. ( PubMed , DOI )

  16. Shinya Akiko, Takahashi Makoto, Sato Nozomu, Nishida Yoichiro, Inaba Akira, Inaji Motoki, Yokota Takanori, Orimo Satoshi: Oculo-dento-digital Dysplasia Presenting as Spastic Paraparesis Which Was Successfully Treated by Intrathecal Baclofen Therapy(和訳中) Internal Medicine. 2021.07; 60 (14): 2301-2305. ( ichushi )

  17. Motohiro Suzuki, Satoru Ishibashi, Eri Iwasawa , Takahiro Oguma, Yasuhiro Saito, Fuying Li, Shinichi Otsu, Keiko Ichinose, Kotaro Yoshioka, Tetsuya Nagata, Takanori Yokota: Effective silencing of miR-126 after ischemic stroke by means of intravenous α-tocopherol-conjugated heteroduplex oligonucleotide in mice. Sci Rep. 2021.07; 11 (1): 14237. ( PubMed , DOI )

  18. Homma H, Tanaka H, Jin M, Jin X, Huang Y, Yoshioka Y, Bertens CJ, Tsumaki K, Kondo K, Shiwaku H, Tagawa K, Akatsu H, Atsuta N, Katsuno M, Furukawa K, Ishiki A, Waragai M, Ohtomo G, Iwata A, Yokota T, Inoue H, Arai H, Sobue G, Sone M, Fujita K, Okazawa H: DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis. Life Sci Alliance. 2021.06; 4 (7): e202101022. ( PubMed , DOI )

  19. Ken Asada, Fumika Sakaue, Tetsuya Nagata, Ji-Chun Zhang, Kie Yoshida-Tanaka, Aya Abe, Makiko Nawa, Kazutaka Nishina , Takanori Yokota: Short DNA/RNA heteroduplex oligonucleotide interacting proteins are key regulators of target gene silencing. Nucleic Acids Res.. 2021.05; 49 (9): 4864-4876. ( PubMed , DOI )

  20. Yoichiro Nishida, Takanori Yokota: Reversible reduction of dopamine transporter uptake in a case of hydrocephalus. Ann Neurol. 2021.05; ( PubMed , DOI )

  21. Nobuo Sanjo, Yurie Nose, Shouhei Miyamoto, Yukiko Shishido-Hara, Tatsuya Saito, Tetsuya Fukuda, Kurara Yamamoto, Daisuke Kobayashi, Takanori Yokota: Early pathological JC virus lesions in a patient without any MRI-based indications Inten Med. 2021.04; 60 (8): 1279-1282. ( ichushi )

  22. Daisuke Ono, Ken Asada, Daishi Yui, Fumika Sakaue, Kotaro Yoshioka, Tetsuya Nagata, Takanori Yokota: Separation-related rapid nuclear transport of DNA/RNA heteroduplex oligonucleotide: unveiling distinctive intracellular trafficking. Mol Ther Nucleic Acids. 2021.03; 23 1360-1370. ( PubMed , DOI )

  23. Hiroaki Yokote, Shuta Toru, Yoichiro Nishida, Takaaki Hattori, Nobuo Sanjo, Takanori Yokota : Serum amyloid A level correlates with T2 lesion volume and cortical volume in patients with multiple sclerosis. J Neuroimmunol. 2021.02; 351 577466. ( PubMed , DOI )

  24. Asami Yutaro, Nagata Tetsuya, Yoshioka Kotaro, Kunieda Taiki, Yoshida-Tanaka Kie, Bennett C. Frank, Seth Punit P., Yokota Takanori: Efficient Gene Suppression by DNA/DNA Double-Stranded Oligonucleotide In Vivo. Mol Ther. 2021.02; 29 (2): 838-847. ( PubMed , DOI )

  25. Akiko Shinya, Makoto Takahashi, Nozomu Sato, Yoichiro Nishida, Akira Inaba, Motoki Inaji, Takanori Yokota, Satoshi Orimo: A case of oculo-dento-digital dysplasia presenting as spastic paraparesis which was successfully treated by intrathecal baclofen therapy. Intern Med. 2021.02; 60 (14): 2301-2305. ( PubMed , DOI )

  26. Mitsuru Naito, Hiroyuki Chaya, Kazuko Toh, Beob Soo Kim, Kotaro Hayashi, Shigeto Fukushima, Tetsuya Nagata, Takanori Yokota, Kazunori Kataoka, Kanjiro Miyata: Structural tuning of oligonucleotides for enhanced blood circulation properties of unit polyion complexes prepared from two-branched poly(ethylene glycol)-block-poly(l-lysine). J control Release . 2021.01; 330 812-820. ( PubMed , DOI )

  27. Mitsuru Watanabe, Yuri Nakamura, Shinya Sato, Masaaki Niino, Hikoaki Fukaura, Masami Tanaka, Hirofumi Ochi, Takashi Kanda, Yukio Takeshita, Takanori Yokota, Yoichiro Nishida, Makoto Matsui, Shigemi Nagayama, Susumu Kusunoki, Katsuichi Miyamoto, Masanori Mizuno, Izumi Kawachi, Etsuji Saji, Takashi Ohashi, Shun Shimohama, Shin Hisahara, Kazutoshi Nishiyama, Takahiro Iizuka, Yuji Nakatsuji, Tatsusada Okuno, Kazuhide Ochi, Akio Suzumura, Ken Yamamoto, Yuji Kawano, Shoji Tsuji, Makoto Hirata, Ryuichi Sakate, Tomonori Kimura, Yuko Shimizu, Akiko Nagaishi, Kazumasa Okada, Fumie Hayashi, Ayako Sakoda, Katsuhisa Masaki, Koji Shinoda, Noriko Isobe, Takuya Matsushita, Jun-Ichi Kira : HLA genotype-clinical phenotype correlations in multiple sclerosis and neuromyelitis optica spectrum disorders based on Japan MS/NMOSD Biobank data. Sci rep. 2021.01; 11 (1): 607. ( PubMed , DOI )

  1. Matsuhisa Koji, Cai Longjie, Saito Atsushi, Sakaue Fumika, Kamikawa Yasunao, Fujiwara Sachiko, Asada Rie, Kudo Yukitsuka, Imaizumi Kazunori: Toxic effects of endoplasmic reticulum stress transducer BBF2H7-derived small peptide fragments on neuronal cells. Brain Res. 2020.12; 1749 147139. ( PubMed , DOI )

  2. Miho Akaza, Shigenori Kawabata, Isamu Ozaki, Yuki Miyano, Taishi Watanabe, Yoshiaki Adachi, Kensuke Sekihara, Yuki Sumi, Takanori Yokota: Noninvasive measurement of sensory action currents in the cervical cord by magnetospinography. Clin Neurophysiol. 2020.12; 132 (2): 382-391. ( PubMed , DOI )

  3. Matsubayashi T, Akaza M, Hayashi Y, Hamaguchi T, Yamada M, Shimohata T, Yokota T, Sanjo N: Focal sharp waves are a specific early-stage marker of the MM2-cortical form of sporadic Creutzfeldt-Jakob disease. Prion. 2020.12; 14 (1): 207-213. ( PubMed , DOI )

  4. Takahashi Sunao, Sanjo Nobuo, Miyamoto Shohei, Hattori Takaaki, Oyama Jun, Tateishi Ukihide, Yokota Takanori: Width of the third ventricle as a highly-sensitive biomarker in chronic progressive neuro-Behçet's disease. J Neurol Sci. 2020.12; 421 117284. ( PubMed , DOI )

  5. Hirata K, Yokota T, Miura Y: Teaching-Neuroimages: Parkinsonism secondary to a metastatic lesion involving the substantia nigra. Neurology. 2020.11; 96 (13): e1800-e1801. ( PubMed , DOI )

  6. Sanjo N, Nose Y, Miyamoto S, Shishido-Hara Y, Saito T, Fukuda T, Yamamoto K, Kobayashi D, Yokota T: Early Pathological JC Virus Lesions in a Patient without any MRI-based Indications. Intern Med. 2020.11; 60 (8): 1279-1282. ( PubMed , DOI )

  7. Sugita Y, Nishida Y, Ishibashi S, Yokota T: Convexity Subarachnoid Hemorrhage Soon after Starting a Direct Oral Anticoagulant in 2 Patients with Acute Infarction. J Stroke Cerebrovasc Dis .. 2020.11; 29 (11): 105216. ( PubMed , DOI )

  8. Hiroyuki Yokoyama, Takashi Hirai, Tetsuya Nagata, Mitsuhiro Enomoto, Hidetoshi Kaburagi, Li Leiyo, Takayuki Motoyoshi, Toshitaka Yoshii, Atsushi Okawa, Takanori Yokota: DNA Microarray Analysis of Differential Gene Expression in the Dorsal Root Ganglia of Four Different Neuropathic Pain Mouse Models. J Pain Res. 2020.11; 13 3031-3043. ( PubMed , DOI )

  9. Kishimoto Y, Nakagawa O, Fujii A, Yoshioka K, Nagata T, Yokota T, Hari Y, Obika S: 2',4'-BNA/LNA with 9-(2-Aminoethoxy)-1,3-diaza-2-oxophenoxazine Efficiently Forms Duplexes and Has Enhanced Enzymatic Resistance*. Chemistry . 2020.10; 27 (7): 2427-2438. ( PubMed , DOI )

  10. Yuko Yamagishi, Motoi Kuwahara, Hidekazu Suzuki, Masahiro Sonoo, Satoshi Kuwabara, Takanori Yokota, Kyoichi Nomura, Atsuro Chiba, Ryuji Kaji, Takashi Kanda, Ken-Ichi Kaida, Tatsuro Mutoh, Ryo Yamasaki, Hiroshi Takashima, Makoto Matsui, Kazutoshi Nishiyama, Gen Sobue, Susumu Kusunoki: Serum IgG anti-GD1a antibody and mEGOS predict outcome in Guillain-Barré syndrome. J Neurol Neurosurg Psychiatry. 2020.10; 91 (12): 1339-1342. ( PubMed , DOI )

  11. Atsushi Irie, Kazuki Sato, Rintaro Iwata Hara, Takeshi Wada, Futoshi Shibasaki: An artificial cationic oligosaccharide combined with phosphorothioate linkages strongly improves siRNA stability. Sci Rep. 2020.09; 10 (1): 14845. ( PubMed , DOI )

  12. Rintaro Iwata Hara, Reijiro Yoshino, Yohei Nukaga, Kazuki Sato, Takeshi Wada: Synthesis and properties of DNA oligomers containing stereopure phosphorothioate linkages and C-5 modified deoxyuridine derivatives RSC Advances. 2020.09; 10 (56): 34006-34013. ( DOI )

  13. Abe T, Yokota T, Fukushima A, Kakutani N, Katayama T, Shirakawa R, Maekawa S, Nambu H, Obata Y, Yamanashi K, Nakano I, Takada S, Yokota I, Okita K, Kinugawa S, Anzai T: Type 2 diabetes is an independent predictor of lowered peak aerobic capacity in heart failure patients with non-reduced or reduced left ventricular ejection fraction. Cardiovascular diabetology. 2020.09; 19 (1): 142. ( PubMed , DOI )

  14. Wenqing Liao, Sakiko Akahira, Rintaro Iwata Hara, Takeshi Wada, Kosuke Kusamori, Yoshinobu Takakura, Makiya Nishikawa: Enhanced Immunostimulatory Activity of CpG Oligodeoxynucleotide by the Combination of Mannose Modification and Incorporation into Nanostructured DNA. Biol Pharm Bull. 2020.08; 43 (8): 1188-1195. ( PubMed , DOI )

  15. Iwase R, Irioka T, Igarashi S, Ayabe J, Yokota T: Intracranial dural arteriovenous fistula mimicking neuromyelitis optica spectrum disorder: A case report. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2020.08; 29 (8): 105007. ( PubMed , DOI )

  16. Kosei Hirata, Takaaki Hattori, Satoko Kina, Qingmeng Chen, Masahiro Ohara, Takanori Yokota: Striatal Dopamine Denervation Impairs Gait Automaticity in Drug-Naïve Parkinson's Disease Patients. Mov. Disord.. 2020.06; 35 (6): 1037-1045. ( PubMed , DOI )

  17. Ryo Iwase, Taro Ishiguro, Kyohei Fujita, Satoru Ishibashi, Takanori Yokota: Dupilumab for Atopic Dermatitis, a Possible Risk Factor of Juvenile Ischemic Stroke: A Case Report. J Stroke Cerebrovasc Dis. 2020.06; 29 (6): 104763. ( PubMed , DOI )

  18. Tai Otani, Takashi Irioka, Susumu Igarashi, Kimihiko Kaneko, Toshiyuki Takahashi, Takanori Yokota: Self-remitting cerebral cortical encephalitis associated with myelin oligodendrocyte glycoprotein antibody mimicking acute viral encephalitis: A case report. Mult Scler Relat Disord. 2020.06; 41 102033. ( PubMed , DOI )

  19. Hirata K, Kobayashi M, Miyashita A, Yokota T: Steroid-responsive myositis in a patient with Sjögren's syndrome and refractory peripheral neuropathy. Neurological sciences . 2020.05; 41 (5): 1303-1305. ( PubMed , DOI )

  20. Jinbing Xie, Daniel Gonzalez-Carter, Theofilus A Tockary, Noriko Nakamura, Yonger Xue, Makoto Nakakido, Hiroki Akiba, Anjaneyulu Dirisala, Xueying Liu, Kazuko Toh, Tao Yang, Zengtao Wang, Shigeto Fukushima, Junjie Li, Sabina Quader, Kouhei Tsumoto, Takanori Yokota, Yasutaka Anraku, Kazunori Kataoka: Dual-Sensitive Nanomicelles Enhancing Systemic Delivery of Therapeutically Active Antibodies Specifically into the Brain. ACS Nano. 2020.05; 14 (6): 6729-6742. ( PubMed , DOI )

  21. Masahiro Ohara, Takaaki Hattori, Takanori Yokota: Progressive supranuclear palsy often develops idiopathic normal pressure hydrocephalus-like MRI features. Eur. J. Neurol.. 2020.05; 27 (10): 1930-1936. ( PubMed , DOI )

  22. Teruhiko Sekiguchi, Satoru Ishibashi, Jo Sasame, Jun-Ichi Mukae, Kotaro Noda, Hiroaki Tanaka, Koh Yamamoto, Yasunori Takemoto, Jiro Kumagai, Takanori Yokota: Recurrent stroke due to quasi-moyamoya disease associated with POEMS syndrome: An autopsy case. J. Neurol. Sci.. 2020.02; 412 116738. ( PubMed , DOI )

  23. Matsuhisa Koji, Saito Atsushi, Cai Longjie, Kaneko Masayuki, Okamoto Takumi, Sakaue Fumika, Asada Rie, Urano Fumihiko, Yanagida Kanta, Okochi Masayasu, Kudo Yukitsuka, Matsumoto Masaki, Nakayama Keiichi I, Imaizumi Kazunori: Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis. FASEB J. 2020.01; 34 (1): 865-880. ( PubMed , DOI )

  24. Okamoto Takumi, Wu Yan, Matsuhisa Koji, Saito Atsushi, Sakaue Fumika, Imaizumi Kazunori, Kaneko Masayuki: Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit. Biochem Biophys Res Commun. 2020.01; 521 (4): 1030-1035. ( PubMed , DOI )

  25. Lei Mon SS, Yoshioka K, Jia C, Kunieda T, Asami Y, Yoshida-Tanaka K, Piao W, Kuwahara H, Nishina K, Nagata T, Yokota T: Highly efficient gene silencing in mouse brain by overhanging-duplex oligonucleotides via intraventricular route. FEBS letters. 2020.01; 594 (9): 1413-1423. ( PubMed , DOI )

  26. Nishida Y, Takahashi YK, Kanai T, Nose Y, Ishibashi S, Sanjo N, Uzawa A, Oda F, Ozawa Y, Kuwabara S, Noguchi E, Suzuki S, Nakahara J, Suzuki N, Ogawa T, Yokoyama K, Hattori N, Konno S, Fujioka T, Kawaguchi N, Hatanaka Y, Sonoo M, Kaneko J, Ogino M, Nishiyama K, Nomura K, Yokota T: Safety of tapering tacrolimus dose in patients with well-controlled anti-acetylcholine receptor antibody-positive myasthenia gravis. European journal of neurology. 2020.01; 27 (1): 100-104. ( PubMed , DOI )

  27. Rintaro Iwata Hara, Kotaro Yoshioka, Takanori Yokota: DNA-RNA Heteroduplex Oligonucleotide for Highly Efficient Gene Silencing. Methods Mol. Biol.. 2020; 2176 113-119. ( PubMed , DOI )

  28. Tsuyoshi Hamaguchi, Nobuo Sanjo, Ryusuke Ae, Yosikazu Nakamura, Kenji Sakai, Masaki Takao, Shigeo Murayama, Yasushi Iwasaki, Katsuya Satoh, Hiroyuki Murai, Masafumi Harada, Tadashi Tsukamoto, Hidehiro Mizusawa, Masahito Yamada.: MM2 type sporadic Creutzfeldt-Jakob disease: new diagnostic criteria for MM2-cortical type. Journal of Neurology, Neurosurgery & Psychiatry . 2020; in press in press.

  29. Kenji Sakai, Tsuyoshi Hamaguchi, Nobuo Sanjo, Hiroyuki Murai, Yasushi Iwasaki, Tadanori Hamano, Mari Honma, Moeko Noguchi-Shinohara, Ichiro Nozaki, Yosikazu Nakamura, Tetsuyuki Kitamoto, Masafumi Harada, Hidehiro Mizusawa, MasahitoYamada. : Diffusion-weighted magnetic resonance imaging in dura mater graftassociated Creutzfeldt-Jakob disease. Journal of the Neurological Sciences . 2020; in press

  1. Wu Yan, Kimura Yuka, Okamoto Takumi, Matsuhisa Koji, Asada Rie, Saito Atsushi, Sakaue Fumika, Imaizumi Kazunori, Kaneko Masayuki: Inflammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation. Sci Rep. 2019.12; 9 (1): 20301. ( PubMed , DOI )

  2. Yanagidaira M, Nishida Y, Yokota T: Temporal correlation between serum CH50 level and symptom severity of myasthenia gravis during eculizumab therapy. Clinical neurology and neurosurgery. 2019.12; 189 105630. ( PubMed , DOI )

  3. Masaki Ohyagi, Takashi Irioka, Takuya Ohkubo, Satoru Ishibashi, Yuko K Takahashi, Eiichiro Amano, Akira Machida, Hiroya Kuwahara, Takanori Yokota: Intrathecal IgG Synthesis and Persistent Inflammation Are Associated with White Matter Lesions in HIV-negative Patients with Cryptococcal Meningoencephalitis. Intern. Med.. 2019.11; 58 (21): 3077-3082. ( PubMed , DOI )

  4. Yokote Hiroaki, Amano Ryota, Toru Shuta, Hattori Takaaki, Nishida Yoichiro, Sanjo Nobuo, Yokota Takanori: 多発性硬化症患者における血清アミロイドA蛋白の上昇と脳萎縮との関連(Brain atrophy is associated with higher serum amyloid A levels in patients with multiple sclerosis) 臨床神経学. 2019.11; 59 (Suppl.): S400. ( ichushi )

  5. Yanagidaira M, Hattori T, Emoto H, Kiyosawa M, Yokota T: Optic perineuritis with anti-myelin oligodendrocyte glycoprotein antibody. Multiple sclerosis and related disorders. 2019.10; 38 101444. ( PubMed , DOI )

  6. Amano Akiko, Sanjo Nobuo, Nakakido Makoto, Tsumoto Kouhei, Matsubara Etsuro, Furukawa Fumiko, Nishida Yoichiro, Saito Takashi, Saido Takaomi, Yokota Takanori: ドットブロット法を用いたマウス脳におけるAβオリゴマーの定量的評価(Quantitative evaluation of Aβ oligomer in mouse brain using dot blot method) Dementia Japan. 2019.10; 33 (4): 515. ( ichushi )

  7. Kazuki Sato , Hiroki Imai , Tomohito Shuto , Rintaro Iwata Hara , Takeshi Wada: Solid-Phase Synthesis of Phosphate/Boranophosphate Chimeric DNAs using the H-Phosphonate–H-Boranophosphonate Method Journal of Organic Chemistry. 2019.10; 84 (23): 15032-15041. ( DOI )

  8. Murai H., Nakamura Y., Matsushita T., Kitamoto T., Tsuboi Y., Sanjo N., Yamada M., Mizusawa H.: Epidemiological study of Gerstmann-Straussler-Scheinker disease with codon 102 mutation in Japan JOURNAL OF THE NEUROLOGICAL SCIENCES. 2019.10; 405 (73): 73 -73. ( DOI )

  9. Ohara M, Sanjo N, Hattori T, Oyama J, Hamada M, Ozaki K, Yokota T: Olivary hypertrophy improved by steroid treatment: Two case reports with unique presentations. Journal of neuroimmunology. 2019.09; 334 577003. ( PubMed , DOI )

  10. Yoshioka K, Kunieda T, Asami Y, Guo H, Miyata H, Yoshida-Tanaka K, Sujino Y, Piao W, Kuwahara H, Nishina K, Hara RI, Nagata T, Wada T, Obika S, Yokota T: Highly efficient silencing of microRNA by heteroduplex oligonucleotides. Nucleic acids research. 2019.08; 47 (14): 7321-7332. ( PubMed , DOI )

  11. , Nobuya Monden, Takahiro Asakage, Naomi Kiyota, Akihiro Homma, Kazuto Matsuura, Nobuhiro Hanai, Takeshi Kodaira, Sadamoto Zenda, Hirofumi Fujii, Makoto Tahara, Tomoya Yokota, Tetsuo Akimoto, Shigemichi Iwae, Tetsuro Onitsuka, Takenori Ogawa, Susumu Okano, Shunji Takahashi, Yasushi Shimizu, Koichiro Yonezawa, Ryuichi Hayashi: A review of head and neck cancer staging system in the TNM classification of malignant tumors (eighth edition). Jpn J Clin Oncol. 2019.07; 49 (7): 589-595. ( PubMed , DOI )

  12. Fujita K, Tanaka K, Yamagami H, Ide T, Ishiyama H, Sonoda K, Satow T, Takahashi JC, Ihara M, Koga M, Yokota T, Toyoda K: Detrimental Effect of Chronic Hypertension on Leptomeningeal Collateral Flow in Acute Ischemic Stroke. Stroke. 2019.07; 50 (7): 1751-1757. ( PubMed , DOI )

  13. Shintaku H, Yamaguchi M, Toru S, Kitagawa M, Hirokawa K, Yokota T, Uchihara T. : Three-dimensional surface models of autopsied human brains constructed from multiple photographs by photogrammetry. PLoS One. 2019.07; 14 (7): ( DOI )

  14. Momoko Ebashi, Shuta Toru, Ayako Nakamura, Satoshi Kamei, Takanori Yokota, Katsuiku Hirokawa, Toshiki Uchihara: Detection of AD-specific four repeat tau with deamidated asparagine residue 279-specific fraction purified from 4R tau polyclonal antibody Acta Neuropathologica. 2019.07; 138 (1): 163-166.

  15. Minikel Eric Vallabh, Vallabh Sonia M., Orseth Margaret C., Brandel Jean-Philippe, Haik Stephane, Laplanche Jean-Louis, Zerr Inga, Parchi Piero, Capellari Sabina, Safar Jiri, Kenny Janna, Fong Jamie C., Takada Leonel T., Ponto Claudia, Hermann Peter, Knipper Tobias, Stehmann Christiane, Kitamoto Tetsuyuki, Ae Ryusuke, Hamaguchi Tsuyoshi, Sanjo Nobuo, Tsukamoto Tadashi, Mizusawa Hidehiro, Collins Steven J., Chiesa Roberto, Roiter Ignazio, de Pedro-Cuesta Jesus, Calero Miguel, Geschwind Michael D., Yamada Masahito, Nakamura Yosikazu, Mead Simon: Age at onset in genetic prion disease and the design of preventive clinical trials NEUROLOGY. 2019.07; 93 (2): E125-E134. ( PubMed , DOI )

  16. Rintaro Iwata Hara, Tatsuya Saito, Tomoki Kogure, Yuka Hamamura, Naoki Uchiyama, Yohei Nukaga, Naoki Iwamoto,Takeshi Wada: Stereocontrolled Synthesis of Boranophosphate DNA by an Oxazaphospholidine Approach and Evaluation of Its Properties Journal of Organic Chemistry. 2019.06; 84 (12): 7971-7983. ( DOI )

  17. Hashiguchi S, Doi H, Kunii M, Nakamura Y, Shimuta M, Suzuki E, Koyano S, Okubo M, Kishida H, Shiina M, Ogata K, Hirashima F, Inoue Y, Kubota S, Hayashi N, Nakamura H, Takahashi K, Katsumoto A, Tada M, Tanaka K, Sasaoka T, Miyatake S, Miyake N, Saitsu H, Sato N, Ozaki K, Ohta K, Yokota T, Mizusawa H, Mitsui J, Ishiura H, Yoshimura J, Morishita S, Tsuji S, Takeuchi H, Ishikawa K, Matsumoto N, Ishikawa T, Tanaka F: Ataxic phenotype with altered CaV3.1 channel property in a mouse model for spinocerebellar ataxia 42. Neurobiology of disease. 2019.06; 130 104516. ( PubMed , DOI )

  18. Otsu S, Ishibashi S, Ozaki K, Yokota T: Elevated lipid peaks during the recovery phase of Baló's concentric sclerosis: A case report. eNeurologicalSci. 2019.06; 15 100191. ( PubMed , DOI )

  19. Ono D, Shishido-Hara Y, Mizutani S, Mori Y, Ichinose K, Watanabe M, Tanizawa T, Yokota T, Uchihara T, Fujigasaki H: Development of demyelinating lesions in progressive multifocal leukoencephalopathy (PML): Comparison of magnetic resonance images and neuropathology of post-mortem brain. Neuropathology : official journal of the Japanese Society of Neuropathology. 2019.06; 39 (4): 294-306. ( PubMed , DOI )

  20. Guo L, Bertola DR, Takanohashi A, Saito A, Segawa Y, Yokota T, Ishibashi S, Nishida Y, Yamamoto GL, Franco JFDS, Honjo RS, Kim CA, Musso CM, Timmons M, Pizzino A, Taft RJ, Lajoie B, Knight MA, Fischbeck KH, Singleton AB, Ferreira CR, Wang Z, Yan L, Garbern JY, Simsek-Kiper PO, Ohashi H, Robey PG, Boyde A, Matsumoto N, Miyake N, Spranger J, Schiffmann R, Vanderver A, Nishimura G, Passos-Bueno MRDS, Simons C, Ishikawa K, Ikegawa S: Bi-allelic CSF1R Mutations Cause Skeletal Dysplasia of Dysosteosclerosis-Pyle Disease Spectrum and Degenerative Encephalopathy with Brain Malformation. American journal of human genetics. 2019.05; 104 (5): 925-935. ( PubMed , DOI )

  21. Ozaki K, Ansai A, Nobuhara K, Araki T, Kubodera T, Ishii T, Higashi M, Sato N, Soga K, Mizusawa H, Ishikawa K, Yokota T: Prevalence and clinicoradiological features of spinocerebellar ataxia type 34 in a Japanese ataxia cohort. Parkinsonism & related disorders. 2019.05; 65 238-242. ( PubMed , DOI )

  22. Uehara T, Choong CJ, Nakamori M, Hayakawa H, Nishiyama K, Kasahara Y, Baba K, Nagata T, Yokota T, Tsuda H, Obika S, Mochizuki H: Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson's disease. Scientific reports. 2019.05; 9 (1): 7567. ( PubMed , DOI )

  23. Hirata K, Numasawa Y, Kobayashi Z, Yokota T: Bilateral Optic Tract Hyperintensity due to Pituitary Apoplexy. Internal medicine (Tokyo, Japan). 2019.04; 58 (8): 1185-1186. ( PubMed , DOI )

  24. Takahashi Yuko K., Nishida Yoichiro, Nose Yurie, Ishibashi Satoru, Sanjo Nobuo, Kanai Tetsuya, Uzawa Akiyuki, Oda Fumiko, Ozawa Yukiko, Kuwabara Satoshi, Yokota Takanori: Calcineurin Inhibitors Can Be Safely Reduced in Most Patients with Well-controlled Myasthenia Gravis NEUROLOGY. 2019.04; 92 (15):

  25. Nishida Yoichiro, Hizume Masaki, Fumimura Yuichi, Ichikawa Tadashi: ドネペジルにより改善した小脳性認知情動症候群(Cerebellar Cognitive Affective Syndrome Improved by Donepezil) Internal Medicine. 2019.04; 58 (7): 1003-1006. ( ichushi )

  26. Ebashi M, Toru S, Nakamura A, Kamei S, Yokota T, Hirokawa K, Uchihara T: Detection of AD-specific four repeat tau with deamidated asparagine residue 279-specific fraction purified from 4R tau polyclonal antibody. Acta neuropathologica. 2019.04; 138 (1): 163-166. ( PubMed , DOI )

  27. Furukawa F, Ishikawa K, Yokota T, Sanjo N: Cross-Sectional Area Analysis of the Head of the Caudate Nucleus in Huntington's Disease. European neurology. 2019.04; 81 (1-2): 13-18. ( PubMed , DOI )

  28. Hashimoto S, Inaji M, Nariai T, Kobayashi D, Sanjo N, Yokota T, Ishii K, Taketoshi M: Usefulness of [11C] Methionine PET in the Differentiation of Tumefactive Multiple Sclerosis from High Grade Astrocytoma. Neurologia medico-chirurgica. 2019.04; 59 (5): 176-183. ( PubMed , DOI )

  29. Takahashi Yuko K., Nishida Yoichiro, Nose Yurie, Ishibashi Satoru, Sanjo Nobuo, Kanai Tetsuya, Uzawa Akiyuki, Oda Fumiko, Ozawa Yukiko, Kuwabara Satoshi, Yokota Takanori: Calcineurin Inhibitors Can Be Safely Reduced in Most Patients with Well-controlled Myasthenia Gravis NEUROLOGY. 2019.04; 92 (15):

  30. Nico J. Diedrich, James Surmeier, Toshiki Uchihara, Sten Grillner, Christopher G. Goetz: Parkinson's disease: Is it a consequence of human brain evolution? Movement Disorders. 2019.04; ３４ (４): ４５３-1531. ( PubMed , DOI )

  31. Rashaun S. Wilson, Navin Rauniyar, Fumika Sakaue, TuKiet T. Lam, Kenneth R. Williams, Angus C. Nairn: Development of Targeted Mass Spectrometry-Based Approaches for Quantitation of Proteins Enriched in the Postsynaptic Density (PSD) proteomes. 2019.04; 7 (2): ( PubMed , DOI )

  32. Yokote H., Amano R., Toru S., Hattori T., Nishida Y., Sanjo N., Yokota T.: Brain Atrophy is Associated with Higher Serum Amyloid A Levels in Patients with Relapsing and Remitting Multiple Sclerosis and Clinically Isolated Syndrome MULTIPLE SCLEROSIS JOURNAL. 2019.03; 25 (3): 442.

  33. Yokote H., Amano R., Toru S., Hattori T., Nishida Y., Sanjo N., Yokota T.: Brain Atrophy is Associated with Higher Serum Amyloid A Levels in Patients with Relapsing and Remitting Multiple Sclerosis and Clinically Isolated Syndrome MULTIPLE SCLEROSIS JOURNAL. 2019.03; 25 (3): 442.

  34. Suzuki S, Naito S, Numasawa Y, Asada M, Shoji N, Zeniya M, Takahashi D, Sato H, Iimori S, Nomura N, Sohara E, Okado T, Ishiwata Y, Nagata M, Rai T, Yokota T, Uchida S: Encephalopathy Induced by High Plasma and Cerebrospinal Fluid Ceftriaxone Concentrations in a Hemodialysis Patient. Internal medicine (Tokyo, Japan). 2019.02; ( PubMed , DOI )

  35. Sanjo N, Nose Y, Shishido-Hara Y, Mizutani S, Sekijima Y, Aizawa H, Tanizawa T, Yokota T: A controlled inflammation and a regulatory immune system are associated with more favorable prognosis of progressive multifocal leukoencephalopathy. Journal of neurology. 2019.02; 266 (2): 369-377. ( PubMed , DOI )

  36. Takahashi K, Yanai S, Takisawa S, Kono N, Arai H, Nishida Y, Yokota T, Endo S, Ishigami A: Vitamin C and vitamin E double-deficiency increased neuroinflammation and impaired conditioned fear memory. Archives of biochemistry and biophysics. 2019.01; 663 120-128. ( PubMed , DOI )

  37. Amano E, Ozaki K, Ishibashi S, Sanjo N, Yokota T: Remarkable improvement in progressive multifocal leukoencephalopathy following acute pyelonephritis with bacteremia. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2019.01; 62 226-228. ( PubMed , DOI )

  38. Maeda Y, Iwata Hara R, Nishina K, Yoshida-Tanaka K, Sakamoto T, Yokota T, Wada T: Artificial cationic peptides that increase nuclease resistance of siRNA without disturbing RNAi activity. Nucleosides, nucleotides & nucleic acids. 2019.01; 38 (5): 338-348. ( PubMed , DOI )

  39. Eiichiro Amano, Kokoro Ozaki, Satoru Ishibashi, Nobuo Sanjo, Takanori Yokota. : Remarkable improvement in progressive multifocal leukoencephalopathy following acute pyelonephritis with bacteremia. Journal of Clinical Neuroscience . 2019; 62 226-228.

  40. Y. Nishida, Y. K. Takahashi, T. Kanai, Y. Nose, S. Ishibashi, N. Sanjo, A. Uzawa, F. Oda, Y. Ozawa, S. Kuwabara, E. Noguchi, S. Suzuki, J. Nakahara, N. Suzuki, T. Ogawa, K. Yokoyama, N. Hattori, S. Konno, T. Fujioka, N. Kawaguchi, Y. Hatanaka, M. Sonoo, J. Kaneko, M. Ogino, K. Nishiyama, K. Nomura, T. Yokota. : Safety of tapering tacrolimus dose in patients with well-controlled anti-acetylcholine receptor antibody-positive myasthenia gravis. European Journal of Neurology . 2019; 27 (1): 100-104.

  41. Eric Vallabh Minikel, Sonia M Vallabh, Margaret C Orseth, Jean-Philippe Brandel, Stéphane Haïk, Jean-Louis Laplanche, Inga Zerr, Piero Parchi, Sabina Capellari, Jiri Safar, Janna Kenny, Jamie C Fong, Leonel T Takada, Claudia Ponto, Peter Hermann, Tobias Knipper, Christiane Stehmann, Tetsuyuki Kitamoto, Ryusuke Ae, Tsuyoshi Hamaguchi, Nobuo Sanjo, Tadashi Tsukamoto, Hidehiro Mizusawa, Steven J Collins, Roberto Chiesa, Ignazio Roiter, Jesús de Pedro-Cuesta, Miguel Calero, Michael D Geschwind, Masahito Yamada, Yosikazu Nakamura, Simon Mead. : Age at onset in genetic prion disease and the design of preventive clinical trials. Neurology. 2019; 93 125-134.

  1. Ozaki K, Ohkubo T, Yamada T, Yoshioka K, Ichijo M, Majima T, Kudo S, Akashi T, Honda K, Ito E, Watanabe M, Sekine M, Hamagaki M, Eishi Y, Sanjo N, Ishibashi S, Mizusawa H, Yokota T: Progressive Encephalomyelitis with Rigidity and Myoclonus Resolving after Thymectomy with Subsequent Anasarca: An Autopsy Case Internal Medicine. 2018.12; 57 (23): 3451-3458. ( ichushi )

  2. Otani T, Irioka T, Takahashi YK, Soga K, Igarashi S, Kaneko K, Takahashi T, Yokota T: Two cases of late-onset neuromyelitis optica spectrum disorder initially presenting with isolated cerebral white matter lesions. eNeurologicalSci. 2018.12; 13 35-37. ( PubMed , DOI )

  3. Nishida Y, Hizume M, Fumimura Y, Ichikawa T: Cerebellar Cognitive Affective Syndrome Improved by Donepezil. Internal medicine (Tokyo, Japan). 2018.12; ( PubMed , DOI )

  4. Miura M, Numasawa Y, Takahisa M, Ozaki K, Irioka T, Nishida Y, Ishibashi S, Yokota T: Levodopa-responsive truncal tremor in a patient with spinocerebellar ataxia type 3. Journal of the neurological sciences. 2018.09; 392 32-33. ( PubMed , DOI )

  5. Sano T, Kobayashi Z, Takaoka K, Ota K, Onishi I, Iizuka M, Tomimitsu H, Shintani S: Retrobulbar optic neuropathy associated with sphenoid sinus mucormycosis. Neurology and clinical neuroscience. 2018.09; 6 (5): 146-147. ( PubMed , DOI )

  6. Miho Akaza, Itaru Akaza, Tadashi Kanouchi, Tetsuo Sasano, Yuki Sumi, Takanori Yokota: Nerve conduction study of the association between glycemic variability and diabetes neuropathy. Diabetol Metab Syndr. 2018.09; 10 69. ( PubMed , DOI )

  7. Rintaro Iwata Hara, Yusuke Maeda, Haruna Fujimaki, Takeshi Wada: Enhancement in RNase H activity of a DNA/RNA hybrid duplex using artificial cationic oligopeptides Chemical Communications. 2018.08; 54 (61): 8526-8529. ( DOI )

  8. Nakamura Tsutomu, Sakaue Fumika, Nasu-Nishimura Yukiko, Takeda Yasuko, Matsuura Ken, Akiyama Tetsu: The Autism-Related Protein PX-RICS Mediates GABAergic Synaptic Plasticity in Hippocampal Neurons and Emotional Learning in Mice. EBioMedicine. 2018.08; 34 189-200. ( PubMed , DOI )

  9. Ozaki K, Ohkubo T, Yamada T, Yoshioka K, Ichijo M, Majima T, Kudo S, Akashi T, Honda K, Ito E, Watanabe M, Sekine M, Hamagaki M, Eishi Y, Sanjo N, Ishibashi S, Mizusawa H, Yokota T: Progressive Encephalomyelitis with Rigidity and Myoclonus Resolving after Thymectomy with Subsequent Anasarca: An Autopsy Case. Internal medicine (Tokyo, Japan). 2018.07; ( PubMed , DOI )

  10. Sasaguri H, Nagata K, Sekiguchi M, Fujioka R, Matsuba Y, Hashimoto S, Sato K, Kurup D, Yokota T, Saido TC: Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID. Nature communications. 2018.07; 9 (1): 2892. ( PubMed , DOI )

  11. Yokote H, Kamata T, Toru S, Sanjo N, Yokota T: Brain volume loss is present in Japanese multiple sclerosis patients with no evidence of disease activity. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2018.07; 39 (10): 1713-1716. ( PubMed , DOI )

  12. Honda T, Nagao S, Hashimoto Y, Ishikawa K, Yokota T, Mizusawa H, Ito M: Tandem internal models execute motor learning in the cerebellum. Proceedings of the National Academy of Sciences of the United States of America. 2018.07; 115 (28): 7428-7433. ( PubMed , DOI )

  13. Rintaro Iwata Hara, Aya Yaoita, Katsuya Takeda, Hiroaki Ueki, Ayumu Ishii, Hideyuki Imoto, Satoshi Kobayashi, Michi Sano, Mihoko Noro, Kazuki Sato, Takeshi Wada: Solid-Phase Synthesis of Fluorinated Analogues of Glycosyl 1-Phosphate Repeating Structures from Leishmania using the Phosphoramidite Method ChemistryOpen. 2018.06; 7 439-446. ( DOI )

  14. Asada K, Ito K, Yui D, Tagaya H, Yokota T: Cytosolic Genomic DNA functions as a Natural Antisense. Scientific reports. 2018.06; 8 (1): 8551. ( PubMed , DOI )

  15. Misawa S, Kuwabara S, Sato Y, Yamaguchi N, Nagashima K, Katayama K, Sekiguchi Y, Iwai Y, Amino H, Suichi T, Yokota T, Nishida Y, Kanouchi T, Kohara N, Kawamoto M, Ishii J, Kuwahara M, Suzuki H, Hirata K, Kokubun N, Masuda R, Kaneko J, Yabe I, Sasaki H, Kaida KI, Takazaki H, Suzuki N, Suzuki S, Nodera H, Matsui N, Tsuji S, Koike H, Yamasaki R, Kusunoki S, Japanese Eculizumab Trial for GBS (JET-GBS) Study Group.: Safety and efficacy of eculizumab in Guillain-Barré syndrome: a multicentre, double-blind, randomised phase 2 trial. The Lancet. Neurology. 2018.06; 17 (6): 519-529. ( PubMed , DOI )

  16. Itaya Sakiko, Kobayashi Zen, Ozaki Kokoro, Sato Nozomu, Numasawa Yoshiyuki, Ishikawa Kinya, Yokota Takanori, Matsuda Hiroshi, Shintani Shuzo: Spinocerebellar Ataxia Type 31 with Blepharospasm Internal Medicine. 2018.06; 57 (11): 1651-1654. ( ichushi )

  17. Li Fuying, Ishibashi Satoru, Iwasawa Eri, Suzuki Motohiro, Ichinose Keiko, Yokota Takanori: Upregulation of lipoprotein receptors on brain endothelial cells and neurons in the early phase of ischemic stroke in mice Journal of Medical and Dental Sciences. 2018.06; 65 (2): 59-71. ( ichushi )

  18. Guo Huijia, Yoshioka Kotaro, Kunieda Taiki, Asami Yutaro, Miyata Haruka, Yoshida-Tanaka Kie, Nagata Tetsuya, Yokota Takanori: Efficacy of microRNA silencing by lipid-conjugated double-stranded antisense oligonucleotides Journal of Medical and Dental Sciences. 2018.06; 65 (2): 83-88. ( ichushi )

  19. Eri Iwasawa, Satoru Ishibashi, Motohiro Suzuki, FuYing Li, Masahiko Ichijo, Kazunori Miki, Takanori Yokota: Sphingosine-1-Phosphate Receptor 1 Activation Enhances Leptomeningeal Collateral Development and Improves Outcome after Stroke in Mice. J Stroke Cerebrovasc Dis. 2018.05; 27 (5): 1237-1251. ( PubMed , DOI )

  20. Higashi M, Ozaki K, Hattori T, Ishii T, Soga K, Sato N, Tomita M, Mizusawa H, Ishikawa K, Yokota T: A diagnostic decision tree for adult cerebellar ataxia based on pontine magnetic resonance imaging. Journal of the neurological sciences. 2018.04; 387 187-195. ( PubMed , DOI )

  21. Hattori T, Ito K, Nakazawa C, Numasawa Y, Watanabe M, Aoki S, Mizusawa H, Ishiai S, Yokota T: Structural connectivity in spatial attention network: reconstruction from left hemispatial neglect. Brain imaging and behavior. 2018.04; 12 (2): 309-323. ( PubMed , DOI )

  22. Nishimaki K, Asada T, Ohsawa I, Nakajima E, Ikejima C, Yokota T, Kamimura N, Ohta S: Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment. Current Alzheimer research. 2018.03; 15 (5): 482-492. ( PubMed , DOI )

  23. Hiroya Kuwahara, Jindong Song, Takahiro Shimoura, Kie Yoshida-Tanaka, Tadahaya Mizuno, Tatsuki Mochizuki, Satoshi Zeniya, Fuying Li, Kazutaka Nishina, Tetsuya Nagata, Shingo Ito, Hiroyuki Kusuhara, Takanori Yokota: Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo. Sci Rep. 2018.03; 8 (1): 4377. ( PubMed , DOI )

  24. Rintaro Iwata Hara, Yuki Hisada, Yusuke Maeda, Takanori Yokota, Takeshi Wada: Artificial cationic oligosaccharides for heteroduplex oligonucleotide-type drugs. Sci Rep. 2018.03; 8 (1): 4323. ( PubMed , DOI )

  25. Amano Eiichiro, Ozaki Kokoro, Egawa Satoru, Suzuki Motohiro, Hirai Takashi, Ishibashi Satoru, Ohkubo Takuya, Yoshii Toshitaka, Okawa Atsushi, Yokota Takanori: Dynamic spinal compression revealed by computed tomography myelography in overshunting-associated myelopathy: A case report. Medicine (Baltimore). 2018.03; 97 (10): e0082. ( PubMed , DOI )

  26. Hiroki Yamada, Takahiro Takeda, Toshiki Uchihara, Shizuko Sato, Susumu Kirimura, Yuka Hirota, Makoto Kodama, Masanobu Kitagawa, Katsuiku Hirokawa, Takanori Yokota, Shuta Toru: Macroscopic Localized Subicular Thinning as a Potential Indicator of Amyotrophic Lateral Sclerosis. Eur. Neurol.. 2018.03; 79 (3-4): 200-205. ( PubMed , DOI )

  27. Yoko Ito, Nobuo Sanjo, Masaki Hizume, Atsushi Kobayashi, Tetsuya Ohgami, Katsuya Satoh, Tsuyoshi Hamaguchi Masahito Yamada, Tetsuyuki Kitamoto, Hidehiro Mizusawa, Takanori Yokota: Biochemical features of genetic Creutzfeldt-Jakob disease with valine-to-isoleucine substitution at codon 180 on the prion protein gene. Biochemical and Biophysical Research Communications. 2018.02; 496 (4): 1055-1061. ( PubMed , DOI )

  28. Rintaro Iwara Hara, Yuta Mitsuhashi, Keita Saito, Yusuke Maeda, Takeshi Wada: Solid-phase synthesis of oligopeptides containing sterically hindered amino acids on non-swellable resin using 3-nitro-1,2,4-triazol-1-yl-tris(pyrrolidin-1-yl)phosphonium hexafluorophosphate (PyNTP) as the condensing reagent ACS Combinatrial Science. 2018.01; 20 132-136. ( DOI )

  29. Hara Y, Mizobe Y, Miyatake S, Takizawa H, Nagata T, Yokota T, Takeda S, Aoki Y: Exon Skipping Using Antisense Oligonucleotides for Laminin-Alpha2-Deficient Muscular Dystrophy. Methods in molecular biology (Clifton, N.J.). 2018; 1828 553-564. ( PubMed , DOI )

  30. Furukawa F, Sanjo N, Kobayashi A, Hamaguchi T, Yamada M, Kitamoto T, Mizusawa H, Yokota T: Specific amyloid-β42 deposition in the brain of a Gerstmann-Sträussler-Scheinker disease patient with a P105L mutation on the prion protein gene. Prion. 2018; 12 (5-6): 315-319. ( PubMed , DOI )

  31. Ohara Masahiro, Ozaki Kokoro, Ohkubo Takuya, Yamada Akane, Numasawa Yoshiyuki, Tanaka Keisuke, Tomii Shohei, Ishibashi Satoru, Sanjo Nobuo, Yokota Takanori: Myasthenia Gravis Complicated with Peripheral T-cell Lymphoma, Not Otherwise Specified (PTCL-NOS), Following Thymectomy and Longstanding Tacrolimus Therapy INTERNAL MEDICINE. 2018; 57 (4): 601-604. ( PubMed , DOI )

  1. Yuko Yamagishi, Hidekazu Suzuki, Masahiro Sonoo, Satoshi Kuwabara, Takanori Yokota, Kyoichi Nomura, Atsuro Chiba, Ryuji Kaji, Takashi Kanda, Kenichi Kaida, Shu-Ichi Ikeda, Tatsuro Mutoh, Ryo Yamasaki, Hiroshi Takashima, Makoto Matsui, Kazutoshi Nishiyama, Gen Sobue, Susumu Kusunoki: Markers for Guillain-Barré syndrome with poor prognosis: a multi-center study. J. Peripher. Nerv. Syst.. 2017.12; 22 (4): 433-439. ( PubMed , DOI )

  2. Masaaki Niino,Toshiyuki Fukazawa,Jun-ichi Kira,Tatsusada Okuno,Masahiro Mori,Nobuo Sanjo,Takashi Ohashi,Hiroaki Fukaura,Juichi Fujimori,Yuko Shimizu,Nobuhiro Mifune,Yusei Miyazaki,Eri Takahashi,Seiji Kikuchi,Dawn Langdon,Ralph HB Benedict,Makoto Matsui: Validation of the Brief International Cognitive Assessment for Multiple Sclerosis in Japan. Multiple Sclerosis Journal. 2017.12; 26 (3): ( PubMed , DOI )

  3. Shuta Toru, Tadashi Kanouchi, Takanori Yokota, Yosuke Yagi, Akira Machida, Takayoshi Kobayashi: Utility of Autonomic Function Tests to Differentiate Dementia with Lewy Bodies and Parkinson Disease with Dementia from Alzheimer Disease. Eur. Neurol.. 2017.11; 79 (1-2): 27-32. ( PubMed , DOI )

  4. Yajun Hu, Yuji Hashimoto, Takashi Ishii, Mamut Rayle, Kazumasa Soga, Nozomu Sato, Michi Okita, Miwa Higashi, Kokoro Ozaki, Hidehiro Mizusawa, Kinya Ishikawa, Takanori Yokota: Sequence configuration of spinocerebellar ataxia type 8 repeat expansions in a Japanese cohort of 797 ataxia subjects. J. Neurol. Sci.. 2017.11; 382 87-90. ( PubMed , DOI )

  5. Tetsuya Kanai, Akiyuki Uzawa, Yasunori Sato, Shigeaki Suzuki, Naoki Kawaguchi, Keiichi Himuro, Fumiko Oda, Yukiko Ozawa, Jin Nakahara, Norihiro Suzuki, Yuko K Takahashi, Satoru Ishibashi, Takanori Yokota, Takashi Ogawa, Kazumasa Yokoyama, Nobutaka Hattori, Shoko Izaki, Satoru Oji, Kyoichi Nomura, Juntaro Kaneko, Kazutoshi Nishiyama, Ichiro Yoshino, Satoshi Kuwabara: A clinical predictive score for postoperative myasthenic crisis. Ann. Neurol.. 2017.11; 82 (5): 841-849. ( PubMed , DOI )

  6. Yuki Kishimoto, Akane Fujii, Osamu Nakagawa, Tetsuya Nagata, Takanori Yokota, Yoshiyuki Hari, Satoshi Obika: Synthesis and thermal stabilities of oligonucleotides containing 2'-O,4'-C-methylene bridged nucleic acid with a phenoxazine base. Org. Biomol. Chem.. 2017.10; 15 (38): 8145-8152. ( PubMed , DOI )

  7. Nishida Y., Winkler E., Sagare A., De Vivo D., Zlokovic B.: Decreased glucose transporter 1 expression at the blood-brain barrier exacerbates Alzheimer disease-like phenotypes in mouse models JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 768. ( DOI )

  8. Yamada A., Numasawa Y., Hattori T., Ozaki K., Ishibashi S., Nishida Y., Kanouchi T., Sanjo N., Takanori Y.: Signal changes of skeletal muscle MRI in peripheral nerve disorders JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 1068. ( DOI )

  9. Ichinose K., Ishibashi S., Miyashita A., Sanjo N., Uchida K., Suzuki Y., Sekine M., Kobayashi D., Eishi Y., Yokota T.: Clinicopathological features of neuromuscular sarcoidosis and its immunoreactivity profiles of P. acne JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 465. ( DOI )

  10. Numasawa Y., Hattori T., Ishiai S., Kobayashi Z., Kamata T., Kotera M., Ishibashi S., Sanjo N., Mizusawa H., Yokota T.: Components of depressive disorder due to raphe-nuclei damage: Subclass analysis of patients with brainstem infarction JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 636. ( DOI )

  11. Hamaguchi T., Sakai K., Kobayashi A., Kitamoto T., Ae R., Nakamura Y., Sanjo N., Arai K., Koide M., Katada F., Tsukamoto T., Mizusawa H., Yamada M.: Investigation of clinical and pathological features of "sporadic Creutzfeldt-Jakob disease" with history of neurosurgery to identify iatrogenic cases JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 416-417. ( DOI )

  12. Y Anraku, H Kuwahara, Y Fukusato, A Mizoguchi, T Ishii, K Nitta, Y Matsumoto, K Toh, K Miyata, S Uchida, K Nishina, K Osada, K Itaka, N Nishiyama, H Mizusawa, T Yamasoba, T Yokota, K Kataoka: Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain. Nat Commun. 2017.10; 8 (1): 1001. ( PubMed , DOI )

  13. Nozomu Sato, Nozomi Toide, Mami Kizawa, Takuya Ohkubo, Satoru Ishibashi, Nobuo Sanjo, Takanori Yokota: Methotrexate-associated lymphoproliferative disorder in a patient with neuromyelitis optica spectrum disorder: An implication for pathogenesis mediated by Epstein-Barr virus. J. Neurol. Sci.. 2017.08; 379 219-221. ( PubMed , DOI )

  14. Hiroaki Yokote,Tomoyuki Kamata,Nobuo Sanjo,Takanori Yokota: Serum retinol levels are associated with brain volume loss in patients with multiple sclerosis. Multiple Sclerosis Journal 2017. 2017.07; 3 (3): ( DOI )

  15. Maya Higuma,Nobuo Sanjo,Hiroshi Mitoma,Mitsuru Yoneyama,Takanori Yokota: Whole-day gait monitoring in patients with Alzheimer's disease: a relationship between attention and gait cycle. Journal of Alzheimer's Disease Reports 2017 . 2017.07; 1 (1): 1-8. ( DOI )

  16. Ohyagi M, Ishibashi S, Ohkubo T, Kobayashi Z, Mizusawa H, Yokota T, Emoto H, Kiyosawa M: Subacute Supranuclear Palsy in anti-Hu Paraneoplastic Encephalitis. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. 2017.07; 44 (4): 444-446. ( PubMed , DOI )

  17. Yokote H, Kamata T, Toru S, Sanjo N, Yokota T: Serum retinol levels are associated with brain volume loss in patients with multiple sclerosis. Multiple sclerosis journal - experimental, translational and clinical. 2017.07; 3 (3): 2055217317729688. ( PubMed , DOI )

  18. Yoshiyuki Numasawa, Takaaki Hattori, Sumio Ishiai, Zen Kobayashi, Tomoyuki Kamata, Minoru Kotera, Satoru Ishibashi, Nobuo Sanjo, Hidehiro Mizusawa, Takanori Yokota.: Depressive disorder is associated with brainstem infarction involving raphe nuclei. Journal of Affective Disorders. 2017.04; (213): 191-198.

  19. Taro Ishiguro, Nozomu Sato, Morio Ueyama, Nobuhiro Fujikake, Chantal Sellier, Akemi Kanegami, Eiichi Tokuda, Bita Zamiri, Terence Gall-Duncan, Mila Mirceta, Yoshiaki Furukawa, Takanori Yokota, Keiji Wada, J. Paul Taylor, Christopher E. Pearson, Nicolas Charlet-Berguerand, Hidehiro Mizusawa, Yoshitaka Nagai, and Kinya Ishikawa: Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31. Neuron. 2017.04; 94 (1): 108-124. ( PubMed , DOI )

  20. Higuma M, Sanjo N, Mitoma H, Yoneyama M, Yokota T: Whole-Day Gait Monitoring in Patients with Alzheimer's Disease: A Relationship between Attention and Gait Cycle. Journal of Alzheimer's disease reports. 2017.04; 1 (1): 1-8. ( PubMed , DOI )

  21. Yoshiyuki Numasawa, Takaaki Hattori, Sumio Ishiai, Zen Kobayashi, Tomoyuki Kamata, Minoru Kotera, Satoru Ishibashi, Nobuo Sanjo, Hidehiro Mizusawa, Takanori Yokota: Depressive disorder may be associated with raphe nuclei lesions in patients with brainstem infarction. Journal of Affective Disorder. 2017.04; 213 191-198. ( PubMed , DOI )

  22. Yokota Takanori: 肝外臓器におけるDNA/RNAヘテロ二本鎖オリゴヌクレオチド(HDO)の作用(The effect of DNA/RNA heteroduplex oligonucleotide (HDO) in extrahepatic organs) Journal of Pharmacological Sciences. 2017.03; 133 (3Suppl.): S43. ( ichushi )

  23. Sakiko Chikazawa, Takaaki Hanafusa, Kokoro Ozaki, Takeshi Namiki, Maki Amano, Makiko Ueno, Shown Tokoro, Ken Igawa, Takefumi Sato, Kinya Ishikawa, Takanori Yokota, Hiroo Yokozeki: Incomplete Behçet's disease with calf muscle pain and MRI hyperintensity due to possible thrombophlebitis. Eur J Dermatol. 2017.02; 27 (1): 76-77. ( PubMed , DOI )

  24. Kazumasa Soga, Kinya Ishikawa, Tokuro Furuya, Tadatsune Iida, Tetsuo Yamada, Noboru Ando, Kiyobumi Ota, Hiromi Kanno-Okada, Shinya Tanaka, Masayuki Shintaku, Yoshinobu Eishi, Hidehiro Mizusawa, Takanori Yokota: Gene dosage effect in spinocerebellar ataxia type 6 homozygotes: A clinical and neuropathological study. J Neurol Sci. 2017.02; 373 321-328. ( PubMed , DOI )

  25. Keisuke Abe, Takuya Ohkubo, Takanori Yokota.: TDP-43 in the skin of amyotrophic lateral sclerosis patients. Journal of Medical and Dental Sciences. 2017.01; 64 (1): 9-17. ( PubMed , DOI )

  26. Yohsuke Yagi, Takuya Ohkubo, Hideya Kawaji, Akira Machida, Haruka Miyata, Saori Goda, Sugata Roy, Yoshihide Hayashizaki, Harukazu Suzuki, Takanori Yokota: Next-generation sequencing-based small RNA profiling of cerebrospinal fluid exosomes. Neurosci. Lett.. 2017.01; 636 48-57. ( PubMed , DOI )

  27. Maya Higuma, Nobuo Sanjo, Hiroshi Mitoma, Mitsuru Yoneyama, Takanori Yokota. : Whole-day gait monitoring in patients with Alzheimer disease: a relationship between attention and gait cycle. Journal of Alzheimer’s Disease Reports. 2017; 1 (1): 1-8.

  28. Iwasawa Eri, Ohkubo Takuya, Kanouchi Tadashi, Kanda Takashi, Mizusawa Hidehiro, Yokota Takanori: Long-term Effects of Intravenous Cyclophosphamide in Combination with Mesna Provided Intravenously and via Bladder Perfusion in a Patient with Severe Multifocal Motor Neuropathy INTERNAL MEDICINE. 2017; 56 (14): 1893-1896. ( PubMed , DOI )

  29. Rintaro Iwata Hara, Yuki Ogawa, Mihoko Noro, Takeshi Wada: Stereocontrolled Synthesis of P-Modified N-Acetylmannosamine-α-1-Phosphate Analogs Chemistry Letters. 2017; 46 1051-1053. ( DOI )

  30. Rintaro Iwata Hara, Satoshi Kobayashi, Mihoko Noro, Kazuki Sato, Takeshi Wada: Synthesis and properties of 2-deoxy-2-fluoromannosyl phosphate derivatives Tetrahedron. 2017; 73 4560-4565. ( DOI )

  31. Rintaro Iwata Hara, Masayuki kageyama, Koichiro Arai, Naoki Uchiyama, Takeshi Wada: Synthesis of 2'-O-monohaloethoxymethyl-modified RNAs and their duplex formation ability RSC Advances. 2017; 7 41297-41303. ( DOI )

  32. Rintaro Iwata Hara, Yusuke Maeda, Taiichi Sakamoto, Takeshi Wada: Double-stranded RNA-binding artificial cationic oligosaccharides stabilizing siRNAs with a low N/P ratio Organic & Biomolecular Chemistry. 2017; 15 (36): 1710-1717. ( DOI )

  1. Nobuko Yamaguchi, Sonoko Misawa, Yasunori Sato, Kengo Nagashima, Kanako Katayama, Yukari Sekiguchi, Yuta Iwai, Hiroshi Amino, Tomoki Suichi, Takanori Yokota, Yoichiro Nishida, Nobuo Kohara, Koichi Hirata, Kazutoshi Nishiyama, Ichiro Yabe, Ken-Ichi Kaida, Norihiro Suzuki, Hiroyuki Nodera, Shoji Tsuji, Haruki Koike, Jun-Ichi Kira, Hideki Hanaoka, Susumu Kusunoki, Satoshi Kuwabara, : A Prospective, Multicenter, Randomized Phase II Study to Evaluate the Efficacy and Safety of Eculizumab in Patients with Guillain-Barré Syndrome (GBS): Protocol of Japanese Eculizumab Trial for GBS (JET-GBS). JMIR Res Protoc. 2016.11; 5 (4): e210. ( PubMed , DOI )

  2. Nobutaka Ishizu, Daishi Yui, Akira Hebisawa, Hidenori Aizawa, Wanpeng Cui, Yuko Fujita, Kenji Hashimoto, Itsuki Ajioka, Hidehiro Mizusawa, Takanori Yokota, Kei Watase: Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice. Hum. Mol. Genet.. 2016.10; 25 (20): 4507-4517. ( PubMed , DOI )

  3. Ryo Yamasaki, Takuya Matsushita, Toshiyuki Fukazawa, Kazumasa Yokoyama, Kazuo Fujihara, Mieko Ogino, Takanori Yokota, Katsuichi Miyamoto, Masaaki Niino, Kyoichi Nomura, Ryo Tomioka, Masami Tanaka, Izumi Kawachi, Takashi Ohashi, Ken-Ichi Kaida, Makoto Matsui, Yuji Nakatsuji, Hirofumi Ochi, Hikoaki Fukaura, Takashi Kanda, Akiko Nagaishi, Kanae Togo, Hidehiro Mizusawa, Hiroyuki Murai, Jun-Ichi Kira: Efficacy of intravenous methylprednisolone pulse therapy in patients with multiple sclerosis and neuromyelitis optica. Mult. Scler.. 2016.09; 22 (10): 1337-1348. ( PubMed , DOI )

  4. Koya Ono, Ken Murata, Toshinari Arai, Tomoyuki Kino, Keisuke Onaka, Satoru Takahashi, Hirotaka Sato, Hiroya Kuwahara: Posterior reversible encephalopathy syndrome after iron administration in a patient with chronic severe anemia. Journal of the Neurological Sciences. 2016.08; 367 333-334. ( PubMed , DOI )

  5. Hamaguchi Tsuyoshi, Taniguchi Yu, Sakai Kenji, Kitamoto Tetsuyuki, Takao Masaki, Murayama Shigeo, Iwasaki Yasushi, Yoshida Mari, Shimizu Hiroshi, Kakita Akiyoshi, Takahashi Hitoshi, Suzuki Hiroyoshi, Naiki Hironobu, Sanjo Nobuo, Mizusawa Hidehiro, Yamada Masahito: Significant association of cadaveric dura mater grafting with subpial A beta deposition and meningeal amyloid angiopathy ACTA NEUROPATHOLOGICA. 2016.08; 132 (2): 313-315. ( PubMed , DOI )

  6. Mitsuru Yoneyama,Hiroshi Mitoma,Nobuo Sanjo, Maya Higuma,Hiroo Terashi,Takanori Yokota: Ambulatory Gait Behavior in Patients with Dementia: A Comparison with Parkinson's Disease. Transactions on Neural System and Rehabilitation Engineering 2015 . 2016.08; 24 (8): 817-826. ( PubMed , DOI )

  7. Iwata Masaaki, Ota Kristie T, Li Xiao-Yuan, Sakaue Fumika, Li Nanxin, Dutheil Sophie, Banasr Mounira, Duric Vanja, Yamanashi Takehiko, Kaneko Koichi, Rasmussen Kurt, Glasebrook Andrew, Koester Anja, Song Dekun, Jones Kenneth A, Zorn Stevin, Smagin Gennady, Duman Ronald S: Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor. Biol Psychiatry. 2016.07; 80 (1): 12-22. ( PubMed , DOI )

  8. Eri Iwasawa, Masahiko Ichijo, Satoru Ishibashi, Takanori Yokota: Acute development of collateral circulation and therapeutic prospects in ischemic stroke. Neural Regen Res. 2016.03; 11 (3): 368-371. ( PubMed , DOI )

  9. Nakamura Tsutomu, Arima-Yoshida Fumiko, Sakaue Fumika, Nasu-Nishimura Yukiko, Takeda Yasuko, Matsuura Ken, Akshoomoff Natacha, Mattson Sarah N, Grossfeld Paul D, Manabe Toshiya, Akiyama Tetsu: PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking. Nat Commun. 2016.03; 7 10861. ( PubMed , DOI )

  10. Nobuo Sanjo,Satoko Kina,Yukiko Shishido-Hara,Yurie Nose,Satoru Ishibashi,Tetsuya Fukuda,Taketoshi Maehara,Yoshinobu Eishi,Hidehiro Mizusawa,Takanori Yokota: A Case of Progressive Multifocal Leukoencephalopathy with Balanced CD4/CD8 T-Cell Infiltration and Good Response to Mefloquine Treatment. Internal Medicine. 2016.01; 55 (12): 1631-1635. ( PubMed , DOI )

  11. Eric Vallabh Minikel,Sonia M. Vallabh,Monkol Lek,Karol O. Estrada,Kaitline E. Samocya,J. Fah Sathirapongsasuti,Cory Y. McLean,Joice Y. Tung,Linda P.C.Yu, Pierluigi Gambetti,Janis Blevins,Shuling Zhamg,Yvonne Cohen,Wei Chen,Masahito Yamada,Tsuyoshi Hamaguchi,Nobuo Sanjo,Hidehiro Mizusawa,Yoshikazu Nakamura,Tetsuyuki Kitamoto,Steven J. Collins,Alison Boyd,Robert G Will,Richard Knight,Claudia Ponto,Inga Zerr,Theo Kraus,Sabina Eigenbrod,Armin Giese,Jesus de Pedro Cuesta,Stéphane Haïk,Jean-Louis Laplanche,Jean Philippe Brandel,Michael Boenke,Markku Laakso,Karen Mohlke,Francis S.Collins,Anna Kähler,Kinberly Chambert, Steven McCarroll,Patrick Sullivan,Christina M. Hultman,Shaun M.Purcell,Pamela Sklar,Cornelia M.van Dujin,F.Rivadeneira Ramirez,Arfan Ikram,Sven J.van der Lee,Jeannette M.Vergeer-Drop,André G.Uitterlinden,Mark J.Daley,Daniel G.MacArthur,: Quantifying prion disease penetrance using large population control cohorts. Science Translational Medicine 2016. 2016.01; 8 (322): 322R9-322RA9. ( PubMed , DOI )

  12. Yutaro Asami, Kotaro Yoshioka, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota: Drug delivery system of therapeutic oligonucleotides. Drug Discov Ther. 2016; 10 (5): 256-262. ( PubMed , DOI )

  13. Mitsuru Yoneyama, Hiroshi Mitoma, Nobuo Sanjo, Maya Higuma, Hiroo Terashi, Takanori Yokota: Ambulatory Gait Behavior in Patients with Dementia: A Comparison with Parkinson’s Disease. Transactions on Neural System and Rehabilitation Engineering. 2016; 24 (8): 817-826.

  14. Yamada K, Kobayashi H, Bo R, Takahashi T, Purevsuren J, Hasegawa Y, Taketani T, Fukuda S, Ohkubo T, Yokota T, Watanabe M, Tsunemi T, Mizusawa H, Takuma H, Shioya A, Ishii A, Tamaoka A, Shigematsu Y, Sugie H, Yamaguchi S: Clinical, biochemical and molecular investigation of adult-onset glutaric acidemia type II: Characteristics in comparison with pediatric cases. Brain Dev. 2016; 38 (3): 293-301.

  15. Enomoto M, Hirai T, Kaburagi H, Yokota T: Efficient Gene Suppression in Dorsal Root Ganglia and Spinal Cord Using Adeno-associated Virus Vectors Encoding Short-Hairpin RNA. Methods Mol Biol. 2016; 1364 277-290.

  16. Ishimura Yuko, Tsukamoto Tadashi, Kuwata Kazuo, Yamada Masahito, Doh-ura Katsumi, Tsuboi Yoshio, Sato Katsuya, Nakamura Yoshikazu, Sanjo Nobuo, Tamura Chieko, Mizusawa Hidehiro: The Japan Consortium of Prion Disease (JACOP) for patients' registration and clinical studies of Prion diseases in Japan PRION. 2016; 10 S106-S107.

  17. Furukawa Fumiko, Sanjo Nobuo, Kobayashi Atsushi, Hamaguchi Tsuyoshi, Yamada Masahito, Kitamoto Tetsuyuki, Mizusawa Hidehiro, Yokota Takanori: Differential association of amyloid-beta with PrPSc pathology in each genetic prion disease PRION. 2016; 10 S85-S86.

  18. Yamada Masahito, Hamaguchi Tsuyoshi, Sakai Kenji, Nozaki Ichiro, Noguchi-Shinohara Moeko, Sanjo Nobuo, Tsukamoto Tadashi, Ae Ryusuke, Nakamura Yosikazu, Kitamoto Tetsuyuki, Mizusawa Hidehiro: Epidemiological and clinical features of human prion diseases in Japan: Prospective 17-year surveillance PRION. 2016; 10 S10-S11.

  1. Masahiro Murakami, Kazutaka Nishina, Chie Watanabe, Kie Yoshida-Tanaka, Wenying Piao, Hiroya Kuwahara, Yuji Horikiri, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka, Masayuki Yoshida, Hidehiro Mizusawa, Takanori Yokota.: Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route. Scientific Reports. 2015.11; 5 17035. ( PubMed , DOI )

  2. Kotaro Yoshioka, Kosuke Watanabe, Satoshi Zeniya, Yoko Ito, Masaki Hizume, Toshiro Kanazawa, Makoto Tomita, Satoru Ishibashi, Hirotomo Miake, Hiroaki Tanaka, Takanori Yokota, Hidehiro Mizusawa: A Score for Predicting Paroxysmal Atrial Fibrillation in Acute Stroke Patients: iPAB Score. J Stroke Cerebrovasc Dis. 2015.10; 24 (10): 2263-2269. ( PubMed , DOI )

  3. M Ichijo, E Iwasawa, Y Numasawa, K Miki, S Ishibashi, M Tomita, H Tomimitsu, T Kamata, H Fujigasaki, S Shintani, H Mizusawa: Significance of Development and Reversion of Collaterals on MRI in Early Neurologic Improvement and Long-Term Functional Outcome after Intravenous Thrombolysis for Ischemic Stroke. AJNR Am J Neuroradiol. 2015.10; 36 (10): 1839-1845. ( PubMed , DOI )

  4. Murai H., Nakamura Y., Kitamoto T., Tsuboi Y., Sanjo N., Yamada M., Mizusawa H., Kira J.: Clinical and epidemiological survey of gerstmann-strausslerscheinker disease with codon 102 mutation in Japan JOURNAL OF THE NEUROLOGICAL SCIENCES. 2015.10; 357 E114. ( DOI )

  5. Yoneyama M, Mitoma H, Higuma M, Sanjo N, Yokota T, Terashi H: Ambulatory Gait Behavior in Patients with Dementia: A Comparison with Parkinson's Disease. IEEE Trans Neural Syst Rehabil Eng. 2015.09;

  6. Kazutaka Nishina, Wenying Piao, Kie Yoshida-Tanaka, Yumiko Sujino, Tomoko Nishina, Tsuyoshi Yamamoto, Keiko Nitta, Kotaro Yoshioka, Hiroya Kuwahara, Hidenori Yasuhara, Takeshi Baba, Fumiko Ono, Kanjiro Miyata, Koichi Miyake, Punit P Seth, Audrey Low, Masayuki Yoshida, C Frank Bennett, Kazunori Kataoka, Hidehiro Mizusawa, Satoshi Obika, Takanori Yokota: DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing. Nat Commun. 2015.08; 6 7969. ( PubMed , DOI )

  7. Hiroya Kuwahara, Kazutaka Nishina, Takanori Yokota.: Blood-brain barrier: a novel therapeutic target in multiple sclerosis. Clinical and Experimental Neuroimmunology.. 2015.05; 6 (2): 129-138. ( DOI )

  8. Yohsuke Yagi, Hiroaki Yokote, Yukiko Watanabe, Takeshi Amino, Tomoyuki Kamata, Susumu Kusunoki: Taste impairment in Miller Fisher syndrome. Neurol. Sci.. 2015.05; 36 (5): 809-810. ( PubMed , DOI )

  9. Ethan A Winkler, Yoichiro Nishida, Abhay P Sagare, Sanket V Rege, Robert D Bell, David Perlmutter, Jesse D Sengillo, Sara Hillman, Pan Kong, Amy R Nelson, John S Sullivan, Zhen Zhao, Herbert J Meiselman, Rosalinda B Wenby, Jamie Soto, E Dale Abel, Jacob Makshanoff, Edward Zuniga, Darryl C De Vivo, Berislav V Zlokovic: GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration. Nat. Neurosci.. 2015.04; 18 (4): 521-530. ( PubMed , DOI )

  10. Colangelo Christopher M, Ivosev Gordana, Chung Lisa, Abbott Thomas, Shifman Mark, Sakaue Fumika, Cox David, Kitchen Robert R, Burton Lyle, Tate Stephen A, Gulcicek Erol, Bonner Ron, Rinehart Jesse, Nairn Angus C, Williams Kenneth R: Development of a highly automated and multiplexed targeted proteome pipeline and assay for 112 rat brain synaptic proteins. Proteomics. 2015.04; 15 (7): 1202-1214. ( PubMed , DOI )

  11. Furukawa Fumiko, Sanjo Nobuo, Higuma Maya, Kitamoto Tetsuyuki, Hizume Masaki, Nakamura Yoshikazu, Yukamoto Tadashi, Murayama Shigeo, Koshi Kagari, Matsukawa Takashi, Tsuji Shoji, Goto Jun, Yamada Masahito, Mizusawa Hidehiro, Yokota Takanori: Clinical features in Gerstmann-Straussler-Scheinker syndrome with P105L mutation PRION. 2015.04; 9 S16.

  12. Minikel Eric Vallabh, Vallabh Sonia M., Lek Monkol, Estrada Karol O., Samocha Kaitlin E., Sathirapongsasuti J. Fah, McLean Cory Y., Tung Joyce Y., Yu Linda P. C., Gambetti Pierluigi, Blevins Janis, Zhang Shulin, Cohen Yvonne, Chen Wei, Yamada Masahito, Hamaguchi Tsuyoshi, Sanjo Nobuo, Mizusawa Hidehiro, Nakamura Yosikazu, Kitamoto Tetsuyuki, Collins Steven J., Boyd Alison, Will Robert G., Knight Richard, Ponto Claudia, Zerr Inga, Kraus Theo F. J., Eigenbrod Sabina, Giese Armin, Calero Miguel, de Pedro-Cuesta Jesus, Haik Stephane, Laplanche Jean-Louis, Bouaziz-Amar Elodie, Brandel Jean-Philippe, Capellari Sabina, Parchi Piero, O'Donnell-Luria Anne H., Karczewski Konrad J., Marshall Jamie L., Boehnke Michael, Laakso Markku, Mohlke Karen L., Kahler Anna, Chambert Kimberly, McCarroll Steven, Sullivan Patrick F., Hultman Christina M., Purcell Shaun M., Sklar Pamela, van der Lee Sven J., Rozemuller Annemieke, Jansen Casper, Hofman Albert, Kraaij Robert, van Rooij Jeroen G. J., Ikram M. Arfan, Uitterlinden Andre G., van Duijn Cornelia M., Daly Mark J., MacArthur Daniel G.: Assessing the pathogenicity of rare PRNP variants by comparing case and control allele frequency PRION. 2015.04; 9 S90-S91.

  13. Hamaguchi Tsuyoshi, Sakai Kenji, Noguchi-Shinohara Moeko, Nozaki Ichiro, Takumi Ichiro, Sanjo Nobuo, Nakamura Yosikazu, Kitamoto Tetsuyuki, Saito Nobuhito, Mizusawa Hidehiro, Yamada Masahito: A comparative study of dura mater graft-associated Creutzfeldt-Jakob disease between Japan and other countries PRION. 2015.04; 9 S23-S24.

  14. Tomoko Nishina, Junna Numata, Kazutaka Nishina, Kie Yoshida-Tanaka, Keiko Nitta, Wenying Piao, Rintaro Iwata, Shingo Ito, Hiroya Kuwahara, Takeshi Wada, Hidehiro Mizusawa, Takanori Yokota.: Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol. Mol Ther Nucleic Acids.. 2015.01; 4 e220. ( PubMed , DOI )

  15. Ohmori H, Hara A, Ishikawa K, Mizusawa H, Ando Y: Clinical characteristics of combined cases of spinocerebellar ataxia types 6 and 31. J Neurogenet. 2015; 29 (2-3): 80-4.

  16. Pedroso JL, Abrahao A, Ishikawa K, Raskin S, de Souza PV, de Rezende Pinto WB, Braga-Neto P, de Albuquerque MV, Mizusawa H, Barsottini OG: When should we test patients with familial ataxias for SCA31? A misdiagnosed condition outside Japan? J Neurol Sci. 2015; 355 (1-2): 206-208.

  17. Yagi Y, Yokote H, Watanabe Y, Amino T, Kamata T, Kusunoki S: Taste impairment in Miller Fisher syndrome. Neurol Sci. 2015; 36 (5): 809-810.

  18. Ohyagi M, Nakamura K, Watanabe M, Fujigasaki H: Embolic stroke during apixaban therapy for left atrial appendage thrombus. J Stroke Cerebrovasc Dis. 2015; 24 (4): e101-102.

  19. Ozaki K, Sanjo N, Ishikawa K, Higashi M, Hattori T, Tanuma N, Miyata R, Hayashi M, Yokota T, Okawa A, Mizusawa H: Elevation of 8-hydroxy-2′-deoxyguanosine in the cerebrospinal fluid of three patients with superficial siderosis. Neurol Clin Neurosci. 2015; 3 (3): 108-110.

  20. Ozaki K, Irioka T, Ishikawa K, Mizusawa H: CADASIL with a novel NOTCH3 mutation (Cys478Tyr). J Stroke Cerebrovasc Dis. 2015; 24 (3): e61-62.

  21. Mitsui J, Matsukawa T, Sasaki H, Yabe I, Matsushima M, Dürr A, Brice A, Takashima H, Kikuchi A, Aoki M, Ishiura H, Yasuda T, Date H, Ahsan B, Iwata A, Goto J, Ichikawa Y, Nakahara Y, Momose Y, Takahashi Y, Hara K, Kakita A, Yamada M, Takahashi H, Onodera O, Nishizawa M, Watanabe H, Ito M, Sobue G, Ishikawa K, Mizusawa H, Kanai K, Hattori T, Kuwabara S, Arai K, Koyano S, Kuroiwa Y, Hasegawa K, Yuasa T, Yasui K, Nakashima K, Ito H, Izumi Y, Kaji R, Kato T, Kusunoki S, Osaki Y, Horiuchi M, Kondo T, Murayama S, Hattori N, Yamamoto M, Murata M, Satake W, Toda T, Filla A, Klockgether T, Wüllner U, Nicholson G, Gilman S, Tanner CM, Kukull WA, Stern MB, Lee VM, Trojanowski JQ, Masliah E, Low PA, Sandroni P, Ozelius LJ, Foroud T, Tsuji S: Variants associated with Gaucher disease in multiple system atrophy. Ann Clin Transl Neurol. 2015; 2 (4): 417-426.

  22. Takenouchi T, Ohyagi M, Torii C, Kosaki R, Takahashi T, Kosaki K: Porencephaly in a fetus and HANAC in her father: variable expression of COL4A1 mutation. Am J Med Genet A. 2015; 167A (1): 156-158.

  23. Nishida Y, Ueda A, Ando Y, Ichikawa T: Skin biopsy-based diagnosis of CADASIL with atypical MRI findings. Intern Med. 2015; 54 (5): 537-538.

  24. Kimura K, Morita H, Daimon M, Kawata T, Nakao T, Lee SL, Hirokawa M, Ebihara A, Nakajima T, Ozawa T, Yonemochi Y, Aida I, Motoyoshi Y, Mikata T, Uchida I, Komori T, Kitao R, Nagata T, Takeda S, Komaki H, Segawa K, Takenaka K, Komuro I : Prognostic impact of venous thromboembolism in patients with Duchenne muscular dystrophy: Prospective multicenter 5-year cohort study. Int J Cardiol. 2015; 191 178-180.

  25. Echigoya Y, Aoki Y, Miskew B, Panesar D, Touznik A, Nagata T, Tanihata J, Nakamura A, Nagaraju K, Yokota T: Long-term efficacy of systemic multiexon skipping targeting dystrophin exons 45-55 with a cocktail of vivo-morpholinos in mdx52 mice. Mol Ther Nucleic Acids. 2015; 4 e225.

  26. Colangelo CM, Ivosev G, Chung L, Abbott T, Shifman M, Sakaue F, Cox D, Kitchen RR, Burton L, Tate SA, Gulcicek E, Bonner R, Rinehart J, Nairn AC, Williams KR: Development of a highly automated and multiplexed targeted proteome pipeline and assay for 112 rat brain synaptic proteins. Proteomics. 2015; 15 (7): 1202-1214.

  27. Masaki Y, Inde T, Nagata T, Tanihata J, Kanamori T, Seio K, Takeda S, Sekine M: Enhancement of exon skipping in mdx52 mice by 2’-O-methyl-2-thioribothymidine incorporation into phosphorothioate oligonucleotides. Med Chem Commun. 2015; 6 630-633.

  28. Yabe I, Matsushima M, Yoshida K, Ishikawa K, Shirai S, Takahashi I, Sasaki H: Rare frequency of downbeat positioning nystagmus in spinocerebellar ataxia type 31. J Neurol Sci. 2015; 350 (1-2): 90-92.

  29. Ishibashi K, Miura Y, Ishikawa K, Ishii K, Ishiwata K: Decreased metabotropic glutamate receptor type 1 availability in a patient with spinocerebellar ataxia type 6: A (11)C-ITMM PET study. J Neurol Sci. 2015; 355 (1-2): 202-205.

  30. Nakamaura Y, Ae R, Takumi I, Sanjo N, Kitamoto T, Yamada M, Mizusawa H: Descriptive epidemiology of prion disease in Japan: 1999-2012. J Epidemiol. 2015; 25 (1): 8-14.

  31. Obayashi M, Stevanin G, Synofzik M, Monin ML, Duyckaerts C, Sato N, Streichenberger N, Vighetto A, Desestret V, Tesson C, Wichmann HE, Illig T, Huttenlocher J, Kita Y, Izumi Y, Mizusawa H, Schöls L, Klopstock T, Brice A, Ishikawa K, Dürr A: Spinocerebellar ataxia type 36 exists in diverse populations and can be caused by a short hexanucleotide GGCCTG repeat expansion. J Neurol Neurosurg Psychiatry. 2015; 86 (9): 986-995.

  32. Rintaro Iwata, Akiko Doi, Yusuke Maeda, Takeshi Wada: Synthesis of oligodiaminomannoses and analysis of their RNA duplex binding properties and their potential application as siRNA-based drugs Organic Biomolecular Chemistry. 2015; 13 9504-9515. ( DOI )

  33. Yosikazu Nakamaura, Ryusuke Ae, Ichiro Takumi, Nobuo Sanjo, Tetsuyuki Kitamoto, Masahito Yamada, Hidehiro Mizusawa. : Descriptive epidemiology of prion disease in Japan: 1999-2012. Journal of Epidemiology . 2015; 25 (1): 8-14.

  34. Yoichiro Nishida, Akihiko Ueda, Yukio Ando, Tadashi Ichikawa: Skin Biopsy-based Diagnosis of CADASIL with Atypical MRI Findings. Intern. Med.. 2015; 54 (5): 537-538. ( PubMed , DOI )

  35. Masahiko Ichijo, Satoru Ishibashi, Fuying Li, Daishi Yui, Kazunori Miki, Hidehiro Mizusawa, Takanori Yokota: Sphingosine-1-Phosphate Receptor-1 Selective Agonist Enhances Collateral Growth and Protects against Subsequent Stroke. PLoS ONE. 2015; 10 (9): e0138029. ( PubMed , DOI )

  36. Iwata R, Nakayama F, Hirochi S, Sato K, Piao W, Nishina K, Yokota T, Wada T: Synthesis and properties of vitamin E analog-conjugated neomycin for delivery of RNAi drugs to liver cells. Bioorg Med Chem Lett. 2015; 25 (4): 815-819.

  37. Yui D, Nishida Y, Nishina T, Mogushi K, Tajiri M, Ishibashi S, Ajioka I, Ishikawa K, Mizusawa H, Murayama S, Yokota T: Enhanced Phospholipase A2 Group 3 Expression by Oxidative Stress Decreases the Insulin-Degrading Enzyme. PLoS One. 2015; 10 (12): e0143518.

  38. Azuma R, Ishikawa K, Hirata K, Hashimoto Y, Takahashi M, Ishii K, Inaba A, Yokota T, Orimo S: A novel mutation of PDE8B Gene in a Japanese family with autosomal-dominant striatal degeneration. Mov Disord. 2015; 30 (14): 1964-1967.

  39. Murakami M, Nishina K, Watanabe C, Yoshida-Tanaka K, Piao W, Kuwahara H, Horikiri Y, Miyata K, Nishiyama N, Kataoka K, Yoshida M, Mizusawa H, Yokota T: Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route. Sci Rep. 2015; 5 17035.

  40. Nishina T, Numata J, Nishina K, Yoshida-Tanaka K, Nitta K, Piao W, Iwata R, Ito S, Kuwahara H, Wada T, Mizusawa H, Yokota T: Chimeric Antisense Oligonucleotide Conjugated to α- Tocopherol. Mol Ther Nucleic Acids. 2015; 4 e220.

  41. Nishina K, Piao W, Yoshida-Tanaka K, Sujino Y, Nishina T, Yamamoto T, Nitta K, Yoshioka K, Kuwahara H, Yasuhara H, Baba T, Ono F, Miyata K, Miyake K, Seth PP, Low A, Yoshida M, Bennett CF, Kataoka K, Mizusawa H, Obika S, Yokota T: DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing. Nat Commun. 2015; 6 7969.

  42. Yoshioka K, Watanabe K, Zeniya S, Ito Y, Hizume M, Kanazawa T, Tomita M, Ishibashi S, Miake H, Tanaka H, Yokota T, Mizusawa H: A Score for Predicting Paroxysmal Atrial Fibrillation in Acute Stroke Patients: iPAB Score. J Stroke Cerebrovasc Dis. 2015; 24 (10): 2263-2269.

  43. Hattori T, Arai A, Yokota T, Imadome K, Tomimitsu H, Miura O, Mizusawa H: Immune-mediated Neuropathy with Epstein-Barrvirus-positive T-cell Lymphoproliferative Disease. Intern Med. 2015; 54 (1): 69-73.

  44. Mizutani S, Usui N, Yokota T, Mizusawa H, Taira M, Katsuyama N: Depth perception from moving cast shadow in macaque monkey. Behav Brain Res. 2015; 288 63-70.

  45. Ozaki K, Doi H, Mitsui J, Sato N, Iikuni Y, Majima T, Yamane K, Irioka T, Ishiura H, Doi K, Morishita S, Higashi M, Sekiguchi T, Koyama K, Ueda N, Miura Y, Miyatake S, Matsumoto N, Yokota T, Tanaka F, Tsuji S, Mizusawa H, Ishikawa K: A Novel Mutation in ELOVL4 Leading to Spinocerebellar Ataxia (SCA) With the Hot Cross Bun Sign but Lacking Erythrokeratodermia: A Broadened Spectrum of SCA34. JAMA Neurol. 2015; 72 (7): 797-805.

  46. Yokote H, Nose Y, Ishibashi S, Tanaka K, Takahashi T, Fujihara K, Yokota T, Mizusawa H: Spinal cord ring enhancement in patients with neuromyelitis optica. Acta Neurol Scand. 2015; 132 (1): 37-41.

  47. Hashimoto Y, Honda T, Matsumura K, Nakao M, Soga K, Katano K, Yokota T, Mizusawa H, Nagao S, Ishikawa K: Quantitative evaluation of human cerebellum-dependent motor learning through prism adaptation of hand-reaching movement. PLoS One. 2015; 10 (3): e0119376.

  48. Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wenby RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV: GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration. Nat Neurosci. 2015; 18 (4): 521-530.

  49. Aikawa T, Mogushi K, Iijima-Tsutsui K, Ishikawa K, Sakurai M, Tanaka H, Mizusawa H, Watase K: Loss of MyD88 alters neuroinflammatory response and attenuates early Purkinje cell loss in a spinocerebellar ataxia type 6 mouse model. Hum Mol Genet. 2015; 24 (17): 4780-4791.

  50. Daishi Yui, Yoichiro Nishida, Tomoko Nishina, Kaoru Mogushi, Mio Tajiri, Satoru Ishibashi, Itsuki Ajioka, Kinya Ishikawa, Hidehiro Mizusawa, Shigeo Murayama, Takanori Yokota: Enhanced Phospholipase A2 Group 3 Expression by Oxidative Stress Decreases the Insulin-Degrading Enzyme. PLoS ONE. 2015; 10 (12): e0143518. ( PubMed , DOI )

  1. Yosikazu Nakamaura, Ryusuke Ae, Ichiro Takumi, Nobuo Sanjo, Tetsuyuki Kitamoto, Masahito Yamada, Hidehiro Mizusawa: Descriptive Epidemiology of Prion Disease in Japan: 1999-2012. J Epidemiol. 2014.10; ( PubMed )

  2. Kazuo Iwasa, Keisuke Shima, Kiyonobu Komai, Yoichiro Nishida, Takanori Yokota, Masahito Yamada: Retinitis pigmentosa and macular degeneration in a patient with ataxia with isolated vitamin E deficiency with a novel c.717 del C mutation in the TTPA gene. J. Neurol. Sci.. 2014.10; 345 (1-2): 228-230. ( PubMed , DOI )

  3. Fumiko Furukawa, Satoru Ishibashi, Nobuo Sanjo, Hiroshi Yamashita, Hidehiro Mizusawa: Serial magnetic resonance imaging changes in sporadic Creutzfeldt-Jakob disease with valine homozygosity at codon 129 of the prion protein gene. JAMA Neurol. 2014.09; 71 (9): 1186-1187. ( PubMed , DOI )

  4. Masahiko Ichijo, Satoru Ishibashi, Takuya Ohkubo, Shosaku Nomura, Nobuo Sanjo, Takanori Yokota, Hidehiro Mizusawa: Elevated platelet microparticle levels after acute ischemic stroke with concurrent idiopathic thrombocytopenic purpura. J Stroke Cerebrovasc Dis. 2014.03; 23 (3): 587-589. ( PubMed , DOI )

  5. Hirai Takashi, Enomoto Mitsuhiro, Kaburagi Hidetoshi, Sotome Shinichi, Yoshida-Tanaka Kie, Ukegawa Madoka, Kuwahara Hiroya, Yamamoto Mariko, Tajiri Mio, Miyata Haruka, Hirai Yukihiko, Tominaga Makoto, Shinomiya Kenichi, Mizusawa Hidehiro, Okawa Atsushi, Yokota Takanori.: Intrathecal AAV serotype 9-mediated delivery of shRNA against TRPV1 attenuates thermal hyperalgesia in a mouse model of peripheral nerve injury. Molecular Therapy.. 2014.02; 22 (2): 409-419. ( PubMed , DOI )

  6. Kuwahara Hiroya, Tsuchiya Kuniaki, Kobayashi Zen, Inaba Akira, Akiyama Haruhiko, Mizusawa Hidehiro.: Cryptococcal meningitis accompanying lymphocytic inflammation predominantly in cerebral deep white matter: a possible manifestation of immune reconstitution inflammatory syndrome. Neuropathology.. 2014.02; 34 (1): 45-48. ( PubMed , DOI )

  7. Rintaro Iwata, Kazutaka Nishina, Takanori Yokota, Takeshi Wada: Synthesis and properties of double-stranded RNA-bindable oligodiaminogalactose derivatives conjugated with vitamin E BIOORGANIC & MEDICINAL CHEMISTRY. 2014.02; 22 (4): 1394-1403. ( DOI )

  8. Teruhiko Sekiguchi, Tadashi Kanouchi, Kazumoto Shibuya, Yu-ichi Noto, Yohsuke Yagi, Akira Inaba, Keisuke Abe, Sonoko Misawa, Satoshi Orimo, Takayoshi Kobayashi, Tomoyuki Kamata, Masanori Nakagawa, Satoshi Kuwabara, Hidehiro Mizusawa, Takanori Yokota: Spreading of amyotrophic lateral sclerosis lesions--multifocal hits and local propagation? J. Neurol. Neurosurg. Psychiatr.. 2014.01; 85 (1): 85-91. ( PubMed , DOI )

  9. Yu Mizuno, Yasuhisa Sakurai, Izumi Sugimoto, Keiko Ichinose, Shoichiro Ishihara, Nobuo Sanjo, Hidehiro Mizusawa, Toru Mannen: Delayed leukoencephalopathy after carbon monoxide poisoning presenting as subacute dementia. Intern. Med.. 2014; 53 (13): 1441-1445. ( PubMed )

  10. Temu Qina, Nobuo Sanjo, Masaki Hizume, Maya Higuma, Makoto Tomita, Ryuichiro Atarashi, Katsuya Satoh, Ichiro Nozaki, Tsuyoshi Hamaguchi, Yosikazu Nakamura, Atsushi Kobayashi, Tetsuyuki Kitamoto, Shigeo Murayama, Hiroyuki Murai, Masahito Yamada, Hidehiro Mizusawa: Clinical features of genetic Creutzfeldt-Jakob disease with V180I mutation in the prion protein gene. BMJ Open. 2014; 4 (5): e004968. ( PubMed , DOI )

  11. Temu Qina, Nobuo Sanjo, Masaki Hizume, Maya Higuma, Makoto Tomita, Ryuichiro Atarashi, Katsuya Satoh, Ichiro Nozaki, Tsuyoshi Hamaguchi, Yosikazu Nakamura, Atsushi Kobayashi, Tetsuyuki Kitamoto, Shigeo Murayama, Hiroyuki Murai, Masahito Yamada, Hidehiro Mizusawa.: Clinical features of genetic Creutzfeldt-Jakob disease with V180I mutation in the prion protein gene. BMJ Open . 2014; 4 (5): e004968.

  12. Furukawa Fumiko, Sanjo Nobuo, Kobayashi Atsushi, Kitamoto Tetsuyuki, Shiraishi Atsushi, Ishikawa Kinya, Honda Haruhisa, Yamada Masahito, Mizusawa Hidehiro: Clinical features of Gerstmann-Straussler-Scheinker syndrome with a P105L mutation and a valine-encoding polymorphic codon 129 in the prion protein gene PRION. 2014; 8 130-131.

  1. Kuwahara Hiroya, Suzuki Shigeharu, Matsumura Ken, Watanabe Mutsufusa, Yakushiji Fumiatsu, Fujigasaki Hiroto.: Ocular flutter, generalized myoclonus, and truncal ataxia in a patient with Graves' ophthalmopathy. Journal of Neurology.. 2013.11; 260 (11): 2906-2907. ( PubMed , DOI )

  2. Tsuyoshi Hamaguchi, Kenji Sakai, Moeko Noguchi-Shinohara, Ichiro Nozaki, Ichiro Takumi, Nobuo Sanjo, Atsuko Sadakane, Yosikazu Nakamura, Tetsuyuki Kitamoto, Nobuhito Saito, Hidehiro Mizusawa, Masahito Yamada: Insight into the frequent occurrence of dura mater graft-associated Creutzfeldt-Jakob disease in Japan. J. Neurol. Neurosurg. Psychiatr.. 2013.10; 84 (10): 1171-1175. ( PubMed , DOI )

  3. Yohsuke Yagi, Yukiko Watanabe, Hiroaki Yokote, Takeshi Amino, Tomoyuki Kamata: Cervical dystonia in an Alzheimer's disease patient treated with donepezil. Acta Neurol Belg. 2013.09; 113 (3): 363-364. ( PubMed , DOI )

  4. Machida Akira, Kuwahara Hiroya, Mayra Azat, Kubodera Takayuki, Hirai Takashi, Sunaga Fumiko, Tajiri Mio, Hirai Yukihiko, Shimada Takashi, Mizusawa Hidehiro, Yokota Takanori.: Intraperitoneal administration of AAV9-shRNA inhibits target gene expression in the dorsal root ganglia of neonatal mice. Molecular Pain.. 2013.07; 9 36. ( PubMed , DOI )

  5. Yohsuke Yagi, Yukiko Watanabe, Hiroaki Yokote, Takeshi Amino, Tomoyuki Kamata: Transient Charles Bonnet syndrome in a patient with reversible cerebral vasoconstriction syndrome. Neurol. Sci.. 2013.06; 34 (6): 1023-1025. ( PubMed , DOI )

  6. Yohsuke Yagi, Yukiko Watanabe, Hiroaki Yokote, Takeshi Amino, Tomoyuki Kamata: Lacunar thalamic infarction with isolated dysesthesia in contralateral fingers. Acta Neurol Belg. 2013.06; 113 (2): 199-200. ( PubMed , DOI )

  7. Hiroaki Yokote, Yohsuke Yagi, Yukiko Watanabe, Takeshi Amino, Tomoyuki Kamata, Hidehiro Mizusawa: Serum amyloid A level is increased in neuromyelitis optica and atypical multiple sclerosis with smaller T2 lesion volume in brain MRI. J. Neuroimmunol.. 2013.06; 259 (1-2): 92-95. ( PubMed , DOI )

  8. Hiroya Kuwahara.: Persistent hemichorea. New England Journal of Medicine. 2013.05; 368 (20): e26. ( PubMed , DOI )

  9. Abhay P Sagare, Robert D Bell, Alaka Srivastava, Jesse D Sengillo, Itender Singh, Yoichiro Nishida, Nienwen Chow, Berislav V Zlokovic: A lipoprotein receptor cluster IV mutant preferentially binds amyloid-β and regulates its clearance from the mouse brain. J. Biol. Chem.. 2013.05; 288 (21): 15154-15166. ( PubMed , DOI )

  10. Yusuke Maeda, Rintaro Iwata, Takeshi Wada: Synthesis and properties of cationic oligopeptides with different side chain lengths that bind to RNA duplexes BIOORGANIC & MEDICINAL CHEMISTRY. 2013.04; 21 (7): 1717-1723. ( DOI )

  11. Piao Wenying, Nishina Kazutaka, Yoshida-Tanaka Kie, Kuwahara Hiroya, Nishina Tomoko, Sakata Mina, Mizusawa Hidehiro, Yokota Takanori: Efficient in vivo delivery of antisense oligonucleotide to choroid plexus. J Med Dent Sci. 2013.03; 60 (1): 9-16. ( PubMed )

  12. Kotaro Yoshioka, Satoru Ishibashi, Atsushi Shiraishi, Takanori Yokota, Hidehiro Mizusawa: Distal hyperintense vessels on FLAIR images predict large-artery stenosis in patients with transient ischemic attack. Neuroradiology. 2013.02; 55 (2): 165-169. ( PubMed , DOI )

  13. Kuwahara Hiroya, Matsumura Ken, Watanabe Mutsufusa, Fujigasaki Hiroto: Intravenous t-PA for the occlusion of an accessory MCA. Intern Med. 2013.01; 52 (1): 163. ( PubMed )

  14. Teruhiko Sekiguchi, Hiroyuki Tomimitsu, Teruhiko Sekiguchi, Yoichiro Nishida, Takashi Irioka, Akira Inaba, Yoshinobu Hoshii: ATTR amyloidosis complicated by phrenic nerve palsy. Can J Neurol Sci. 2013.01; 40 (1): 129-130. ( PubMed )

  15. Zen Kobayashi, Miho Akaza, Yoshiyuki Numasawa, Shoichiro Ishihara, Hiroyuki Tomimitsu, Kazuo Nakamichi, Masayuki Saijo, Tomohiro Morio, Norio Shimizu, Nobuo Sanjo, Shuzo Shintani, Hidehiro Mizusawa: Failure of mefloquine therapy in progressive multifocal leukoencephalopathy: report of two Japanese patients without human immunodeficiency virus infection. J. Neurol. Sci.. 2013.01; 324 (1-2): 190-194. ( PubMed , DOI )

  16. Yusuke Maeda, Rintaro Iwata, Takeshi Wada: Synthesis of Novel Oligocationic Peptides Binding to RNA Duplexes Peptide Science 2012. 2013; 23-24.

  17. Kazunori Sano, Katsuya Satoh, Ryuichiro Atarashi, Hiroshi Takashima, Yasushi Iwasaki, Mari Yoshida, Nobuo Sanjo, Hiroyuki Murai, Hidehiro Mizusawa, Matthias Schmitz, Inga Zerr, Yong-Sun Kim, Noriyuki Nishida: Early detection of abnormal prion protein in genetic human prion diseases now possible using real-time QUIC assay. PLoS ONE. 2013; 8 (1): e54915. ( PubMed , DOI )

  18. Maya Higuma, Nobuo Sanjo, Katsuya Satoh, Yusei Shiga, Kenji Sakai, Ichiro Nozaki, Tsuyoshi Hamaguchi, Yosikazu Nakamura, Tetsuyuki Kitamoto, Susumu Shirabe, Shigeo Murayama, Masahito Yamada, Jun Tateishi, Hidehiro Mizusawa: Relationships between clinicopathological features and cerebrospinal fluid biomarkers in Japanese patients with genetic prion diseases. PLoS ONE. 2013; 8 (3): e60003. ( PubMed , DOI )

  19. Takumi Hori, Nobuo Sanjo, Makoto Tomita, Hidehiro Mizusawa: Visual Reproduction on the Wechsler Memory Scale-Revised as a predictor of Alzheimer's disease in Japanese patients with mild cognitive impairments. Dement Geriatr Cogn Disord. 2013; 35 (3-4): 165-176. ( PubMed , DOI )

  20. Kenji Sakai, Tsuyoshi Hamaguchi, Moeko Noguchi-Shinohara, Ichiro Nozaki, Ichiro Takumi, Nobuo Sanjo, Yosikazu Nakamura, Tetsuyuki Kitamoto, Nobuhito Saito, Hidehiro Mizusawa, Masahito Yamada: Graft-related disease progression in dura mater graft-associated Creutzfeldt-Jakob disease: a cross-sectional study. BMJ Open. 2013; 3 (8): e003400. ( PubMed , DOI )

  21. Kenji Sakai, Tsuyoshi Hamaguchi, Moeko Noguchi-Shinohara, Ichiro Nozaki, Ichiro Takumi, Nobuo Sanjo, Yosikazu Nakamura, Tetsuyuki Kitamoto, Nobuhito Saito, Hidehiro Mizusawa, Masahito Yamada.: Graft-related disease progression in dura mater graft-associated Creutzfeldt-Jakob disease: a cross-sectional study. BMJ Open. 2013; 3 (8): e003400.

  22. Kazunori Sano, Katsuya Satoh, Ryuichiro Atarashi, Hiroshi Takashima, Yasushi Iwasaki, Mari Yoshida, Nobuo Sanjo, Hiroyuki Murai, Hidehiro Mizusawa, Matthias Schmitz, Inga Zerr, Yong-Sun Kim, Noriyuki Nishida.: Early Detection of Abnormal Prion Protein in Genetic Human Prion Diseases Now Possible Using Real-Time QUIC Assay. PLoS One. 2013; 8 (1): e54915.

  23. Maya Higuma, Nobuo Sanjo, Katsuya Satoh, Yusei Shiga, Kenji Sakai, Ichiro Nozaki, Tsuyoshi Hamaguchi, Yosikazu Nakamura, Tetsuyuki Kitamoto, Susumu Shirabe, Shigeo Murayama, Masahito Yamada, Jun Tateishi, Hidehiro Mizusawa.: Relationships between Clinicopathological Features and Cerebrospinal Fluid Biomarkers in Japanese Patients with Genetic Prion Diseases. PLoS One. 2013; 8 (3): e60003.

  24. Takumi Hori, Nobuo Sanjo, Makoto Tomita, Hidehiro Mizusawa. : Visual Reproduction on the Wechsler Memory Scale-Revised as a predictor of Alzheimer’s disease in Japanese patients with mild cognitive impairments. Dementia and Geriatric Cognitive Disorders. 2013; 35 165-176.

  25. Masaki Ohyagi, Takuya Ohkubo, Yousuke Yagi, Satoru Ishibashi, Junko Akiyama, Masakazu Nagahori, Mamoru Watanabe, Takanori Yokota, Hidehiro Mizusawa: Chronic inflammatory demyelinating polyradiculoneuropathy in a patient with Crohn's disease. Intern. Med.. 2013; 52 (1): 125-128. ( PubMed )

  26. Yohsuke Yagi, Nobuo Sanjo, Takanori Yokota, Hidehiro Mizusawa: Tacrolimus monotherapy: a promising option for ocular myasthenia gravis. Eur. Neurol.. 2013; 69 (6): 344-345. ( PubMed , DOI )

  27. Teruhiko Sekiguchi, Yoichiro Nishida, Akira Inaba, Shigeo Toyota: Mesothelioma-mimicking multiple myeloma with dumbbell-type progression. Intern. Med.. 2013; 52 (11): 1287-1288. ( PubMed )

  1. Yohsuke Yagi, Akira Machida, Shuta Toru, Takayoshi Kobayashi, Tomonari Amano, Katsuiku Hirokawa, Masanobu Kitagawa: Myotonic dystrophy and lipoma: a new association. Neurol. Sci.. 2012.12; 33 (6): 1477-1478. ( PubMed , DOI )

  2. 三條 伸夫, Qina Temu, 日熊 麻耶, Fraser Paul, 水澤 英洋: アミロイドβ産生に及ぼすI143Tの変異を持つPSEN1の影響(An Effect of PSEN1 with I143T Mutation on Amyloid β Production) Dementia Japan. 2012.10; 26 (4): 515. ( ichushi )

  3. Masaki Ohyagi, Nobuo Sanjo, Takanori Yokota, Hidehiro Mizusawa: Hereditary neuropathy with liability to pressure palsy combined with suspected schwannomas of the peroneal and radial nerves. J. Neurol.. 2012.05; 259 (5): 977-979. ( PubMed , DOI )

  4. Hirai Takashi, Enomoto Mitsuhiro, Machida Akira, Yamamoto Mariko, Kuwahara Hiroya, Tajiri Mio, Hirai Yukihiko, Sotome Shinichi, Mizusawa Hidehiro, Shinomiya Kenichi, Okawa Atsushi, Yokota Takanori: Intrathecal shRNA-AAV9 inhibits target protein expression in the spinal cord and dorsal root ganglia of adult mice. Hum Gene Ther Methods. 2012.04; 23 (2): 119-127. ( PubMed , DOI )

  5. Kuwahara Hiroya, Yokota Takanori: Delivery of siRNA into the blood-brain barrier: recent advances and future perspective. Ther Deliv. 2012.04; 3 (4): 417-420. ( PubMed )

  6. Uchida Azusa, Sasaguri Hiroki, Kimura Nobuyuki, Tajiri Mio, Ohkubo Takuya, Ono Fumiko, Sakaue Fumika, Kanai Kazuaki, Hirai Takashi, Sano Tatsuhiko, Shibuya Kazumoto, Kobayashi Masaki, Yamamoto Mariko, Yokota Shigefumi, Kubodera Takayuki, Tomori Masaki, Sakaki Kyohei, Enomoto Mitsuhiro, Hirai Yukihiko, Kumagai Jiro, Yasutomi Yasuhiro, Mochizuki Hideki, Kuwabara Satoshi, Uchihara Toshiki, Mizusawa Hidehiro, Yokota Takanori: Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43. Brain. 2012.03; 135 (Pt 3): 833-846. ( PubMed , DOI )

  7. Kuwahara Hiroya, Matsunaga Shin-ichi: Central pontine myelinolysis associated with pancreatic diabetes. J Neurol. 2012.02; 259 (2): 353-354. ( PubMed , DOI )

  8. Yusuke Maeda, Rintaro Iwata, Takeshi Wada: Synthesis of Novel Oligocationic Peptides which Bind to A-Type Nucleic Acid Duplexes Peptide Science 2011. 2012; 231-232.

  9. Koji Fujita, Masafumi Harada, Makoto Sasaki, Tatsuhiko Yuasa, Kenji Sakai, Tsuyoshi Hamaguchi, Nobuo Sanjo, Yusei Shiga, Katsuya Satoh, Ryuichiro Atarashi, Susumu Shirabe, Ken Nagata, Tetsuya Maeda, Shigeo Murayama, Yuishin Izumi, Ryuji Kaji, Masahito Yamada, Hidehiro Mizusawa: Multicentre multiobserver study of diffusion-weighted and fluid-attenuated inversion recovery MRI for the diagnosis of sporadic Creutzfeldt-Jakob disease: a reliability and agreement study. BMJ Open. 2012; 2 (1): e000649. ( PubMed , DOI )

  10. Koji Fujita, Masafumi Harada, Makoto Sasaki, Tatsuhiko Yuasa, Kenji Sakai, Tsuyoshi Hamaguchi, Nobuo Sanjo, Yusei Shiga, Katsuya Satoh, Ryuichiro Atarashi, Susumu Shirabe, Ken Nagata, Tetsuya Maeda, Shigeo Murayama, Yuishin Izumi, Ryuji Kaji, Masahito Yamada, Hidehiro Mizusawa. : Multicentre, multiobserver study of diffusion-weighted and fluid-attenuated inversion recovery MRI for the diagnosis of sporadic Creutzfeldt–Jakob disease: a reliability and agreement study. BMJ open. 2012; 2 e000649.

  11. Yoichiro Nishida, Tadashi Ichikawa: Pontine hyperperfusion during recovery from central pontine myelinolysis. Intern. Med.. 2012; 51 (7): 817-818. ( PubMed )

  12. Sanjo Nobuo: Clinical features of genetic prion disease and cerebrospinal fluid findings in Japanese patients PRION. 2012; 6 128.

  1. Yoko Ito,Nobuo Sanjo,Kinya Ishikawa,Osamu Tao,Takanori Yokota,Hidehiro Mizusawa: Brainstem congestion due to carotid-cavernous fistula via a shunt from the external calotid artery. Journal of Neurology . 2011.12; (258): 2288-2290. ( PubMed , DOI )

  2. Kuwahara H, Nishina K, Yoshida K, Nishina T, Yamamoto M, Saito Y, Piao W, Yoshida M, Mizusawa H, Yokota T: Efficient in vivo delivery of siRNA into brain capillary endothelial cells along with endogenous lipoprotein. Mol Ther. 2011.12; 19 (12): 2213-2221. ( PubMed , DOI )

  3. Yohsuke Yagi, Akira Machida, Shuta Toru, Takayoshi Kobayashi, Toshiki Uchihara: Sialidosis type I with neoplasms in siblings: the first clinical cases. Neurol. Sci.. 2011.08; 32 (4): 737-738. ( PubMed , DOI )

  4. Kuwahara Hiroya, Nakatsuru Enichi, Ozawa Naoko: Exertional rhabdomyolysis affecting anterior compartment of unilateral lower leg. Intern Med. 2011.04; 50 (7): 793. ( PubMed )

  5. Rintaro Iwata, Masafumi Sudo, Kenta Nagafuji, Takeshi Wada: Synthesis of Oligodiaminosaccharides Having alpha-Glycoside Bonds and Their Interactions with Oligonucleotide Duplexes Journal of Organic Chemistry. 2011; 76 (15): 5895-5906. ( DOI )

  1. Kuwahara Hiroya, Noguchi Yoshimasa, Saito Yukinobu, Inaba Akira: Multiple cavernous angiomas in the brain and spinal cord. Arch Neurol. 2010.11; 67 (11): 1405-1406. ( PubMed , DOI )

  2. Kuwahara Hiroya, Tsuchiya Kuniaki, Saito Yukinobu, Kobayashi Zen, Miyazaki Hiroshi, Izumiyama Yoko, Akiyama Haruhiko, Arai Tetsuaki, Mizusawa Hidehiro: Frontotemporal lobar degeneration with motor neuron disease showing severe and circumscribed atrophy of anterior temporal lobes. J Neurol Sci. 2010.10; 297 (1-2): 92-96. ( PubMed , DOI )

  3. Nobuo Sanjo, Taiichi Katayama, Hiroshi Hasegawa, Haifeng Jin, Monika Duthie, Howard T J Mount, Hidehiro Mizusawa, Peter St George-Hyslop, Paul E. Fraser: Localization and trafficking of endogenous anterior pharynx-defective 1, a component of Alzheimer's disease related gamma-secretase. Neurosci. Lett.. 2010.10; 483 (1): 53-56. ( PubMed , DOI )

  4. Ichiro Nozaki, Tsuyoshi Hamaguchi, Nobuo Sanjo, Moeko Noguchi-Shinohara, Kenji Sakai, Yosikazu Nakamura, Takeshi Sato, Tetsuyuki Kitamoto, Hidehiro Mizusawa, Fumio Moriwaka, Yusei Shiga, Yoshiyuki Kuroiwa, Masatoyo Nishizawa, Shigeki Kuzuhara, Takashi Inuzuka, Masatoshi Takeda, Shigetoshi Kuroda, Koji Abe, Hiroyuki Murai, Shigeo Murayama, Jun Tateishi, Ichiro Takumi, Susumu Shirabe, Masafumi Harada, Atsuko Sadakane, Masahito Yamada: Prospective 10-year surveillance of human prion diseases in Japan. Brain. 2010.10; 133 (10): 3043-3057. ( PubMed , DOI )

  5. Yoichiro Nishida, Takashi Irioka, Teruhiko Sekiguchi, Hidehiro Mizusawa: Pure sensory infarct in the territories of anterior cerebral artery. Neurology. 2010.07; 75 (3): 287. ( PubMed , DOI )

  6. Nakamura Tsutomu, Hayashi Tomoatsu, Mimori-Kiyosue Yuko, Sakaue Fumika, Matsuura Ken, Iemura Shun-ichiro, Natsume Toru, Akiyama Tetsu: The PX-RICS-14-3-3zeta/theta complex couples N-cadherin-beta-catenin with dynein-dynactin to mediate its export from the endoplasmic reticulum. J Biol Chem. 2010.05; 285 (21): 16145-16154. ( PubMed , DOI )

  7. Haifeng Jin, Nobuo Sanjo, Toshiki Uchihara, Kazuhiko Watabe, Peter St George-Hyslop, Paul E Fraser, Hidehiro Mizusawa: Presenilin-1 holoprotein is an interacting partner of sarco endoplasmic reticulum calcium-ATPase and confers resistance to endoplasmic reticulum stress. J. Alzheimers Dis.. 2010; 20 (1): 261-273. ( PubMed , DOI )

  8. Nobuo Sanjo, Taiichi Katayama, Hiroshi Hasegawa, Haifeng Jin, Monika Duthie, Howard T.J. Mount, Hidehiro Mizusawa, Peter St George-Hyslop, Paul E. Fraser. : Localization and trafficking of endogenous anterior pharynx-defective 1, a component of Alzheimer's disease related γ-secretase. Neuroscience Lett 2010; 483(1): 53-56. 2010; 483 (1): 53-56.

  9. 三條伸夫, 佐々木真理, 水澤英洋, プリオン病画像小委員会: 脳外科手術によるCJDリスク保因可能性者事例の経過と注意すべきプリオン病画像診断のポイント. CI研究. 2010; 31 (4): 233-239.

  10. Ichiro Nozaki, Tsuyoshi Hamaguchi, Nobuo Sanjo, Kenji Sakai, Moeko Noguchi-Shinohara, Yosikazu Nakamura, Takeshi Sato, Tetsuyuki Kitamoto, Hidehiro Mizusawa, Fumio Moriwaka, Yusei Shiga, Yoshiyuki Kuroiwa, Masatoyo Nishizawa, Shigeki Kuzuhara, Takashi Inuzuka, Masatoshi Takeda, Shigetoshi Kuroda, Koji Abe, Hiroyuki Murai, Shigeo Murayama, Jun Tateishi, Ichiro Takumi, Susumu Sirabe, Masafumi Harada, Masahito Yamada. : Prospective 10-years surveillance for human prion diseases in Japan. Brain 133(10); 2010, 3043-57. 2010; 133 (10): 3043-3057.

  1. Yoichiro Nishida, Shingo Ito, Sumio Ohtsuki, Naoki Yamamoto, Tsubura Takahashi, Nobuhisa Iwata, Kou-Ichi Jishage, Hiromi Yamada, Hiroki Sasaguri, Shigefumi Yokota, Wenying Piao, Hiroyuki Tomimitsu, Takaomi C Saido, Katsuhiko Yanagisawa, Tetsuya Terasaki, Hidehiro Mizusawa, Takanori Yokota: Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease. J. Biol. Chem.. 2009.11; 284 (48): 33400-33408. ( PubMed , DOI )

  2. Rintaro Iwata, Masafumi Sudo, Kenta Nagafuji, Takeshi Wada: Stabilization of A-type nucleic acid duplexes by novel oligodiaminosaccharides Nucleic Acids Symposium Series. 2009.10; 53 (1): 113-114. ( DOI )

  3. Takashi Irioka, Ayaka Yamanami, Yohsuke Yagi, Hidehiro Mizusawa: Aortic dissection as a possible cause of pure transient global amnesia: a case report and literature review. Neurol. Sci.. 2009.06; 30 (3): 255-258. ( PubMed , DOI )

  4. Yoichiro Nishida, Yuki Saito, Takanori Yokota, Takashi Kanda, Hidehiro Mizusawa: Skeletal muscle MRI in complex regional pain syndrome. Intern. Med.. 2009; 48 (4): 209-212. ( PubMed )

  1. Nakamura Tsutomu, Hayashi Tomoatsu, Nasu-Nishimura Yukiko, Sakaue Fumika, Morishita Yasuyuki, Okabe Toshio, Ohwada Susumu, Matsuura Ken, Akiyama Tetsu: PX-RICS mediates ER-to-Golgi transport of the N-cadherin/beta-catenin complex. Genes Dev. 2008.05; 22 (9): 1244-1256. ( PubMed , DOI )

  1. Hayashi Tomoatsu, Okabe Toshio, Nasu-Nishimura Yukiko, Sakaue Fumika, Ohwada Susumu, Matsuura Ken, Akiyama Tetsu, Nakamura Tsutomu: PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development. Genes Cells. 2007.08; 12 (8): 929-939. ( PubMed , DOI )

  2. Katayama Taiichi, Sanjo Nobuo, Fraser Paul, George-Hyslop Peter St., Sato Kohji: インビボクロスリンク法を用いたガンマセクレターゼ新規構成蛋白質の探索(A screening for novel components of gamma-secretase complex using by in vivo crosslink method) 神経化学. 2007.08; 46 (2-3): 484. ( ichushi )

  3. Yoichiro Nishida, Hiroshi Komachi, Hidehiro Mizusawa: A case of Listeria meningitis associated with increased adenosine deaminase in cerebrospinal fluid. Diagn. Microbiol. Infect. Dis.. 2007.04; 57 (4): 435-437. ( PubMed , DOI )

  4. Shiraishi Atsushi, Hino Taro, Kyodo Toride, Sanjo Nobuo, Ishibashi Satoru, Machida Akira, Mizutani Saneyuki, Shintani Shuzo, Mizusawa Hidehiro: Dual-plane diffusion-weighted imaging can improve the detection of diffusion-restricted lesions in patients who were suspected of stroke with mild severity: Axial and coronal DWI for acute stroke (ACORDAS) study STROKE. 2007.02; 38 (2): 495.

  1. Yoichiro Nishida, Takanori Yokota, Tsubura Takahashi, Toshiki Uchihara, Kou-ichi Jishage, Hidehiro Mizusawa: Deletion of vitamin E enhances phenotype of Alzheimer disease model mouse. Biochem. Biophys. Res. Commun.. 2006.11; 350 (3): 530-536. ( PubMed , DOI )

  2. Yong-Ri Ren, Yoichiro Nishida, Kenji Yoshimi, Toru Yasuda, Kou-Ichi Jishage, Toshiki Uchihara, Takanori Yokota, Yoshikuni Mizuno, Hideki Mochizuki: Genetic vitamin E deficiency does not affect MPTP susceptibility in the mouse brain. J. Neurochem.. 2006.09; 98 (6): 1810-1816. ( PubMed , DOI )

  3. Fusheng Chen, Hiroshi Hasegawa, Gerold Schmitt-Ulms, Toshitaka Kawarai, Christopher Bohm, Taiichi Katayama, Yongjun Gu, Nobuo Sanjo, Michael Glista, Ekaterina Rogaeva, Yosuke Wakutani, Raphaëlle Pardossi-Piquard, Xueying Ruan, Anurag Tandon, Frédéric Checler, Philippe Marambaud, Kirk Hansen, David Westaway, Peter St George-Hyslop, Paul Fraser: TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. Nature. 2006.04; 440 (7088): 1208-1212. ( PubMed , DOI )

  4. Sasaki Takahiro, Gotow Takahiro, Shiozaki Motoko, Sakaue Fumika, Saito Taro, Julien Jean-Pierre, Uchiyama Yasuo, Hisanaga Shin-Ichi: Aggregate formation and phosphorylation of neurofilament-L Pro22 Charcot-Marie-Tooth disease mutants. Hum Mol Genet. 2006.03; 15 (6): 943-952. ( PubMed , DOI )

  5. Toshiki Uchihara, Nobuo Sanjo, Ayako Nakamura, Kyung Han, Si-Young Song, Peter St George-Hyslop, Paul E Fraser: Transient abundance of presenilin 1 fragments/nicastrin complex associated with synaptogenesis during development in rat cerebellum. Neurobiol. Aging. 2006.01; 27 (1): 88-97. ( PubMed , DOI )

  6. Uchihara T, Sanjo N, Nakamura A, Han K, Song SY, St George-Hyslop P, Fraser P.: Transient abundance of presenilin 1 fragments/nicastrin complex associated with synaptogenesis during development in rat cerebellum. Neurobiol Aging . 2006; 27 (1): 88-97.

  1. Agnes Petit, Toshitaka Kawarai, Erwan Paitel, Nobuo Sanjo, Mary Maj, Michael Scheid, Fusheng Chen, Yongjun Gu, Hiroshi Hasegawa, Shabnam Salehi-Rad, Linda Wang, Ekaterina Rogaeva, Paul Fraser, Brian Robinson, Peter St George-Hyslop, Anurag Tandon: Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations. J. Biol. Chem.. 2005.10; 280 (40): 34025-34032. ( PubMed , DOI )

  2. Sakaue Fumika, Saito Taro, Sato Yutaka, Asada Akiko, Ishiguro Koichi, Hasegawa Masato, Hisanaga Shin-ichi: Phosphorylation of FTDP-17 mutant tau by cyclin-dependent kinase 5 complexed with p35, p25, or p39. J Biol Chem. 2005.09; 280 (36): 31522-31529. ( PubMed , DOI )

  3. Koyama Rikako, Nakanishi Koji, Kato Masako, Yamashita Shigeo, Kuwahara Hiroya, Katori Hideyuki: Hypoglycemia and hyperglycemia due to insulin antibodies against therapeutic human insulin: treatment with double filtration plasmapheresis and prednisolone. Am J Med Sci. 2005.05; 329 (5): 259-264. ( PubMed )

  4. Petit A, Kawarai T, Paitel E, Sanjo N, Maj M, Scheid M, Chen F, Gu Y, Hasegawa H, Salehi-Rad S, Wang L, Rogaeva E, Fraser P, Robinson B, St George-Hyslop P, Tandon A (2005): Wild-type PINK1 Prevents Basal and Induced Neuronal Apoptosis, a Protective Effect Abrogated by Parkinson Disease-related Mutations. J Biol Chem. 2005; 280 34025-34032.

  1. Y Nishida, N Sodeyama, Y Toru, S Toru, T Kitamoto, H Mizusawa: Creutzfeldt-Jakob disease with a novel insertion and codon 219 Lys/Lys polymorphism in PRNP. Neurology. 2004.11; 63 (10): 1978-1979. ( PubMed )

  2. Hiroshi Hasegawa, Nobuo Sanjo, Fusheng Chen, Yong-Jun Gu, Cortney Shier, Agnes Petit, Toshitaka Kawarai, Taiichi Katayama, Stephen D Schmidt, Paul M Mathews, Gerold Schmitt-Ulms, Paul E Fraser, Peter St George-Hyslop: Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes. J. Biol. Chem.. 2004.11; 279 (45): 46455-46463. ( PubMed , DOI )

  3. Yongjun Gu, Nobuo Sanjo, Fusheng Chen, Hiroshi Hasegawa, Agnes Petit, Xueying Ruan, Wenping Li, Cortney Shier, Toshitaka Kawarai, Gerold Schmitt-Ulms, David Westaway, Peter St George-Hyslop, Paul E Fraser: The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities. J. Biol. Chem.. 2004.07; 279 (30): 31329-31336. ( PubMed , DOI )

  4. Sumio Ishiai, Yasumasa Koyama, Naomi Nakano, Keiko Seki, Yoichiro Nishida, Kazuko Hayashi: Image of a line is not shrunk but neglected. Absence of crossover in unilateral spatial neglect. Neuropsychologia. 2004; 42 (2): 251-256. ( PubMed )

  5. Hasegawa H, Sanjo N, Chen F, Gu YJ, Shier C, Petit A, Kawarai, T., Katayama, T., Schmidt, S. D., Mathews, P. M., Schmitt-Ulms, G., Fraser, P. E., St George-Hyslop, P. : Both the sequence and length of the C-terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes. Journal of Biological Chemistry . 2004; 279 (45): 46455-46463.

  6. Gu Y*, Sanjo N*, Chen F*, Hasegawa H, Petit A, Ruan X, Li, W., Shier, C., Kawarai, T., Schmitt-Ulms, G., Westaway, D., St George-Hyslop, P., Fraser, P. E. (*: equally contributed): The presenilin proteins are components of multiple membrane-bound complexes which have different biological activities. Journal of Biological Chemistry . 2004; 279 (30): 31329-31336.

  1. Fusheng Chen, Anurag Tandon, Nobuo Sanjo, Yong-Jun Gu, Hiroshi Hasegawa, Shigeki Arawaka, Frank J S Lee, Xueying Ruan, Peter Mastrangelo, Serap Erdebil, Linda Wang, David Westaway, Howard T J Mount, Bruce Yankner, Paul E Fraser, Peter St George-Hyslop: Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain. J. Biol. Chem.. 2003.05; 278 (22): 19974-19979. ( PubMed , DOI )

  2. Kazuko Aoki, Toshiki Uchihara, Nobuo Sanjo, Ayako Nakamura, Kenji Ikeda, Kuniaki Tsuchiya, Yoshihiro Wakayama: Increased expression of neuronal apolipoprotein E in human brain with cerebral infarction. Stroke. 2003.04; 34 (4): 875-880. ( PubMed , DOI )

  3. Yongjun Gu, Fusheng Chen, Nobuo Sanjo, Toshitaka Kawarai, Hiroshi Hasegawa, Monica Duthie, Wenping Li, Xueying Ruan, Anchla Luthra, Howard T J Mount, Anurag Tandon, Paul E Fraser, Peter St George-Hyslop: APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes. J. Biol. Chem.. 2003.02; 278 (9): 7374-7380. ( PubMed , DOI )

  4. Aoki K., Uchihara T., Sanjo N., Nakamura A., Ikeda K., Tsuchiya K. and Wakayama Y. : Increased Expression of Neuronal Apolipoprotein E in Human Brain With Cerebral Infarction. Stroke 2003; 34: 875-80.. 2003; 34 875-880.

  5. Chen F., Tandon A., Sanjo N., Gu Y. J., Hasegawa H., Arawaka S., Lee F. J., Ruan X., Mastrangelo P., Erdebil S., Wang L., Westaway D., Mount H. T., Yankner B., Fraser P. E. and St George-Hyslop P. : Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in mammalian brain. Journal of Biological Chemistry. 2003; 278 (22): 19974-19979.

  6. Gu Y, Chen F, Sanjo N, Kawarai T, Hasegawa H, Duthie M, Li W, Ruan X, Luthra A, Mount HT, Tsndon A, Fraser PE and St. George-Hyslop P. : APH-1 Interacts with Mature and Immature Forms of Presenilins and Nicastrin and May Play a Role in Maturation of Presenilin-Nicastrin Complexes Journal of Biological Chemistry. 2003; 278 7374-7380.

  1. Y Nishida, M Yamada, K Hara, T Tsunemi, M Yamawaki, R Shimokawa, R Okeda, T Tsutsumi, H Mizusawa: Creutzfeldt-Jakob disease after Jannetta's operation with cadaveric dura mater graft: initial manifestations related to the grafted site. J. Neurol.. 2002.04; 249 (4): 480-483. ( PubMed , DOI )

  1. 三條　伸夫, 上原　晋, 井浦　泰夫, 松本　卓, 市川　忠.: ＭＲＩ上椎骨・脳底動脈領域血管に異常を有する脳血管障害患者における未破裂脳動脈瘤保有率の検討. リハビリテーション医学. 2000; 37 165-170.

  1. K Owada, N Sanjo, T Kobayashi, H Mizusawa, H Muramatsu, T Muramatsu, M Michikawa: Midkine inhibits caspase-dependent apoptosis via the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase in cultured neurons. J. Neurochem.. 1999.11; 73 (5): 2084-2092. ( PubMed )

  2. Owada K, Sanjo N, Kobayashi T, Mizusawa H, Muramatsu H, Muramatsu T, Michikawa M.: Midkine inhibits Caspase-dependent apoptosis via the activation of Mitogen-activated protein kinase and phosphatidylinositol 3-kinase in cultured neurons. Journal of Neurochemistory . 1999; 73 (5): 2084-2092.

  3. Owada K, Sanjo N, Kobayashi T, Kamata T, Mizusawa H, Muramatsu H, Muramatsu T and Michikawa M. : Midkine inhibits apoptosis via extracellular signal regulated kinase (ERK) activation in PC12 cells. Journal of Medical and Dental Science . 1999; 46 45-51.

  1. N Sanjo, K Owada, T Kobayashi, H Mizusawa, A Awaya, M Michikawa: A novel neurotrophic pyrimidine compound MS-818 enhances neurotrophic effects of basic fibroblast growth factor. J. Neurosci. Res.. 1998.12; 54 (5): 604-612. ( PubMed )

  1. N Sanjo, T Yokota, Y Saitou, H Miake, H Tanaka: Painful bilateral abducens nerve palsy associated with anti-neutrophil cytoplasmic autoantibodies. J. Neurol.. 1996.08; 243 (8): 612-613. ( PubMed )

  1. Rintaro Iwata Hara, Takeshi Wada: New molecular technologies for stabilization and activation of nucleic acid drugs Dementia Japan. 2018; 32 597-606.

  1. Takanori Yokota, Kazutaka Nishina, Hiroya Kuwahara: Gene Therapy with therapeutic oligonucleotides Neurological Therapeutics. 2016.11; 33 (3): 303-306.

  2. Yokota T, Kanouchi T, Ohkubo T: ALS: Quantitative analysis of disease progression from a new point of view 2015 Annual report of the research committee of CNS degenerative diseases, The ministry of health, labour and welfare of Japan. 2016.03; 58-61.

  1. Kazutaka Nishina, Kotaro Yoshioka, Hiroya Kuwahara, Takanori Yokota.: Gene therapy for neurological disorder using therapeutic oligonucleotides. Neurological Medicine. 2015.10; 83 (4): 283-288.

  2. Hiroya Kuwahara, Takanori Yokota.: Nano-DDS for oligonucleotide therapeutics. Cell Technology. 2015.10; 34 (10): 939-945.

  3. Hiroya Kuwahara, Toshiki Uchihara, Mitsuru Kawamura.: An autopsy case of amyotrophic lateral sclerosis presenting with flail arm syndrome and rapid progression of respiratory failure. Brain Nerve.. 2015.05; 67 (5): 639-650.

  1. Hiroya Kuwahara, Kazutaka Nishina, Takanori Yokota.: Drug delivery system for nucleic acie therapeutics. 2014.02; 40 (2): 19-22.

  1. Nobuo Sanjo, Hidehiro Mizusawa: [Prion disease--the characteristics and diagnostic points in Japan]. Clinical Neurology. 2010.05; 50 (5): 287-300. ( PubMed )

  1. Hiroya Kuwahara, Yoshimasa Noguchi, Akira Inaba, Hidehiro Mizusawa: Case of an 81-year-old woman with theophylline-associated seizures followed by partial seizures due to vitamin B6 deficiency. Rinsho Shinkeigaku. 2008.02; 48 (2): 125-129. ( PubMed )

  1. Nobuo Sanjo: [Acquired Creutzfeldt-Jakob disease (CJD)--Kuru, iatrogenic CJD, variant CJD]. 2007.08; 65 (8): 1438-1445. ( PubMed )

  1. Zeniya S, Kuwahara H, Daizo K, Watari A, Kondoh M, Yoshida-Tanaka K, Kaburagi H, Asada K, Nagata T, Nagahama M, Yagi K, Yokota T: Angubindin-1 opens the blood-brain barrier in vivo for delivery of antisense oligonucleotide to the central nervous system. Journal of controlled release : official journal of the Controlled Release Society. 2018.05; ( PubMed , DOI )

  1. Yoshioka K, Kuwahara H, Nishina K, Nagata T, Yokota T: [Recent progress and prospect in oligonucleotide therapeutics]. Nihon rinsho. Japanese journal of clinical medicine. 2015.06; 73 (6): 1057-1065. ( PubMed )

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